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Conserved domains on  [gi|1958769349|ref|XP_038963456|]
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DENN domain-containing protein 11 isoform X2 [Rattus norvegicus]

Protein Classification

DENND11 family protein( domain architecture ID 12102159)

DENND11 family protein is a DUF2347 domain-containing protein; similar to Homo sapiens protein LCHN, a probable guanine nucleotide exchange factor (GEF) that may promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DENND11 pfam09804
DENN domain-containing protein 11; DENN domain-containing protein 11 (also known as LCHN) is ...
 1-256 1.23e-89

DENN domain-containing protein 11; DENN domain-containing protein 11 (also known as LCHN) is thought to play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia.


:

Pssm-ID: 430838  Cd Length: 283  Bit Score: 270.70  E-value: 1.23e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769349   1 MVEWCLP-QDIDLEGVEFKSMASGSHKVQSDFIYFRKGPFFGLACFANMPVESELERGARMKSVGILSPS----YTLLYR 75
Cdd:pfam09804  13 TIVWSKSlPDVDLEGVEFKSLPSGIHEVSEDLVYFVHEDYYGLSAFRQNPVDEEEERGAKMYSVGVLCDSsngfIGALWR 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769349  76 YMHFLENQVRHQLEMPGHYSHLAAFYEDKKgvLHAGPGRGGSLPP--VYWLPSIHRYM-----YPEMKITHPAGCMSQFI 148
Cdd:pfam09804  93 YAEFLKSLAKHFLESEGNYSPLEEYFETYK--ARKVTGDQASSSPdsHSRNRSLSDVAvletpRPPLSPYHPAGSLPELL 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769349 149 KFFGEQILILWKFALLRKRILIFSPPPVGVVCYRVYCCCCLANVSLPGIGGTIPE---SKPFFYVNVADIESLE--VEVS 223
Cdd:pfam09804 171 DKLGPLIFPLYKAALLRKRILFFSSPPVEPLCSFVYCLSLLSSIPISLEALLPPElsrLRPLFNVGLHDIPFLEkfKKEG 250

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1958769349 224 YVACTTEKIFEEKRELYDVYVDNQNVKTHHDHL 256
Cdd:pfam09804 251 WIACTTDEILESKPELYDVLVDLPPNSSPNAKI 283
 
Name Accession Description Interval E-value
DENND11 pfam09804
DENN domain-containing protein 11; DENN domain-containing protein 11 (also known as LCHN) is ...
 1-256 1.23e-89

DENN domain-containing protein 11; DENN domain-containing protein 11 (also known as LCHN) is thought to play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia.


Pssm-ID: 430838  Cd Length: 283  Bit Score: 270.70  E-value: 1.23e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769349   1 MVEWCLP-QDIDLEGVEFKSMASGSHKVQSDFIYFRKGPFFGLACFANMPVESELERGARMKSVGILSPS----YTLLYR 75
Cdd:pfam09804  13 TIVWSKSlPDVDLEGVEFKSLPSGIHEVSEDLVYFVHEDYYGLSAFRQNPVDEEEERGAKMYSVGVLCDSsngfIGALWR 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769349  76 YMHFLENQVRHQLEMPGHYSHLAAFYEDKKgvLHAGPGRGGSLPP--VYWLPSIHRYM-----YPEMKITHPAGCMSQFI 148
Cdd:pfam09804  93 YAEFLKSLAKHFLESEGNYSPLEEYFETYK--ARKVTGDQASSSPdsHSRNRSLSDVAvletpRPPLSPYHPAGSLPELL 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769349 149 KFFGEQILILWKFALLRKRILIFSPPPVGVVCYRVYCCCCLANVSLPGIGGTIPE---SKPFFYVNVADIESLE--VEVS 223
Cdd:pfam09804 171 DKLGPLIFPLYKAALLRKRILFFSSPPVEPLCSFVYCLSLLSSIPISLEALLPPElsrLRPLFNVGLHDIPFLEkfKKEG 250

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1958769349 224 YVACTTEKIFEEKRELYDVYVDNQNVKTHHDHL 256
Cdd:pfam09804 251 WIACTTDEILESKPELYDVLVDLPPNSSPNAKI 283
 
Name Accession Description Interval E-value
DENND11 pfam09804
DENN domain-containing protein 11; DENN domain-containing protein 11 (also known as LCHN) is ...
 1-256 1.23e-89

DENN domain-containing protein 11; DENN domain-containing protein 11 (also known as LCHN) is thought to play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia.


Pssm-ID: 430838  Cd Length: 283  Bit Score: 270.70  E-value: 1.23e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769349   1 MVEWCLP-QDIDLEGVEFKSMASGSHKVQSDFIYFRKGPFFGLACFANMPVESELERGARMKSVGILSPS----YTLLYR 75
Cdd:pfam09804  13 TIVWSKSlPDVDLEGVEFKSLPSGIHEVSEDLVYFVHEDYYGLSAFRQNPVDEEEERGAKMYSVGVLCDSsngfIGALWR 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769349  76 YMHFLENQVRHQLEMPGHYSHLAAFYEDKKgvLHAGPGRGGSLPP--VYWLPSIHRYM-----YPEMKITHPAGCMSQFI 148
Cdd:pfam09804  93 YAEFLKSLAKHFLESEGNYSPLEEYFETYK--ARKVTGDQASSSPdsHSRNRSLSDVAvletpRPPLSPYHPAGSLPELL 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769349 149 KFFGEQILILWKFALLRKRILIFSPPPVGVVCYRVYCCCCLANVSLPGIGGTIPE---SKPFFYVNVADIESLE--VEVS 223
Cdd:pfam09804 171 DKLGPLIFPLYKAALLRKRILFFSSPPVEPLCSFVYCLSLLSSIPISLEALLPPElsrLRPLFNVGLHDIPFLEkfKKEG 250

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1958769349 224 YVACTTEKIFEEKRELYDVYVDNQNVKTHHDHL 256
Cdd:pfam09804 251 WIACTTDEILESKPELYDVLVDLPPNSSPNAKI 283
SPA pfam08616
Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque ...
 144-245 3.25e-09

Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque of the spindle pole body. In Aspergillus nidulans the protein member is necessary for stabilization of the polarity axes during septation. and in S. cerevisiae it functions as a polarization-specific docking factor.


Pssm-ID: 400783  Cd Length: 113  Bit Score: 54.22  E-value: 3.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769349 144 MSQFIKFFGEQILILWKFALLRKRILIFSP-PPVGVVCYRVYCCCCLANvslPGIGGTIPESKPFFYVNVADIESLEVEV 222
Cdd:pfam08616   4 LLKLLGPFTPPIILLINALLTSKRIIFLSYqRSAGEVSEFVLALCNLIS---GGFVLRGFTNNSFPYVDLSKLDALRKVP 80

                          90       100
                  ....*....|....*....|...
gi 1958769349 223 SYVACTTEKIFEEKRELYDVYVD 245
Cdd:pfam08616  81 GYIAGVTNPIFENQDQWWDVLCD 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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