N-acetyl-D-glucosamine kinase isoform X3 [Rattus norvegicus]
N-acetylglucosamine kinase( domain architecture ID 1903937)
N-acetylglucosamine kinase of eukaryotic type similar to Clostridium acetobutylicum N-acetylmuramic acid/N-acetylglucosamine kinase.
List of domain hits
Name | Accession | Description | Interval | E-value | |||
ASKHA_ATPase-like super family | cl49607 | ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA ... |
4-157 | 6.54e-92 | |||
ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA superfamily, also known as actin-like ATPase domain superfamily, includes acetate and sugar kinases, heat-shock cognate 70 (Hsp70) and actin family proteins. They either function as conformational hydrolases (e.g. Hsp70, actin) that perform simple ATP hydrolysis, or as metabolite kinases (e.g. glycerol kinase) that catalyze the transfer of a phosphoryl group from ATP to their cognate substrates. Both activities depend on the presence of specific metal cations. ASKHA superfamily members share a common core fold that includes an actin-like ATPase domain consisting of two subdomains (denoted I _ II) with highly similar ribonuclease (RNase) H-like folds. The fold of each subdomain is characterized by a central five strand beta-sheet and flanking alpha-helices. The two subdomains form an active site cleft in which ATP binds at the bottom. Another common feature of ASKHA superfamily members is the coupling of phosphoryl-group transfer to conformational rearrangement, leading to domain closure. Substrate binding triggers protein motion. The actual alignment was detected with superfamily member cd24078: Pssm-ID: 483947 [Multi-domain] Cd Length: 314 Bit Score: 270.22 E-value: 6.54e-92
|
|||||||
Name | Accession | Description | Interval | E-value | |||
ASKHA_NBD_NAGK_meta | cd24078 | nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ... |
4-157 | 6.54e-92 | |||
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called N-acetylglucosamine kinase, or GlcNAc kinase, converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. It is involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. NAGK also has ManNAc kinase activity. Members in this family are mainly from metazoa. Pssm-ID: 466928 [Multi-domain] Cd Length: 314 Bit Score: 270.22 E-value: 6.54e-92
|
|||||||
BadF | COG2971 | BadF-type ATPase, related to human N-acetylglucosamine kinase [Carbohydrate transport and ... |
7-155 | 2.12e-32 | |||
BadF-type ATPase, related to human N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Pssm-ID: 442210 [Multi-domain] Cd Length: 298 Bit Score: 117.29 E-value: 2.12e-32
|
|||||||
BcrAD_BadFG | pfam01869 | BadF/BadG/BcrA/BcrD ATPase family; This family includes the BadF and BadG proteins that are ... |
7-155 | 3.45e-09 | |||
BadF/BadG/BcrA/BcrD ATPase family; This family includes the BadF and BadG proteins that are two subunits of Benzoyl-CoA reductase, that may be involved in ATP hydrolysis. The family also includes an activase subunit from the enzyme 2-hydroxyglutaryl-CoA dehydratase. The protein Swiss:O66634 contains two copies of this region suggesting that the family may structurally dimerize. This family appears to be related to pfam00370. Pssm-ID: 396441 [Multi-domain] Cd Length: 271 Bit Score: 54.28 E-value: 3.45e-09
|
|||||||
Name | Accession | Description | Interval | E-value | |||
ASKHA_NBD_NAGK_meta | cd24078 | nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ... |
4-157 | 6.54e-92 | |||
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called N-acetylglucosamine kinase, or GlcNAc kinase, converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. It is involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. NAGK also has ManNAc kinase activity. Members in this family are mainly from metazoa. Pssm-ID: 466928 [Multi-domain] Cd Length: 314 Bit Score: 270.22 E-value: 6.54e-92
|
|||||||
ASKHA_NBD_eukNAGK-like | cd24007 | nucleotide-binding domain (NBD) of the eukaryotic-type N-acetylglucosamine kinase (NAGK) ... |
7-155 | 3.04e-36 | |||
nucleotide-binding domain (NBD) of the eukaryotic-type N-acetylglucosamine kinase (NAGK) family; The eukaryotic-type NAGK-like family includes a group of proteins similar to eukaryotic N-acetyl-D-glucosamine kinases, such as Vibrio cholerae glucosamine kinase GspK, Sulfurisphaera tokodaii ATP-dependent hexokinase (StHK), Thermoplasma acidophilum 2-dehydro-3-deoxygluconokinase (KdgK) and Clostridium acetobutylicum N-acetylmuramic acid/N-acetylglucosamine kinase (MurK). NAGK (EC 2.7.1.59), also called GlcNAc kinase, converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. It is involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. NAGK also has ManNAc kinase activity. GspK (EC 2.7.1.8), also called GlcN kinase, acts as ATP-dependent kinase, which is specific for glucosamine. StHK is a novel hexokinase that can phosphorylate not only glucose but also GlcNAc, glucosamine, and mannose. KdgK (EC 2.7.1.45), also called 2-keto-3-deoxy-D-gluconate kinase, or KDG kinase, catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG). It is specific for KDG. MurK (EC 2.7.1.-/EC 2.7.1.59), also known MurNAc/GlcNAc kinase, or murein sugar kinase, catalyzes the ATP-dependent phosphorylation of both cell wall (peptidoglycan) amino sugars, N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), at the 6-hydroxyl group. The eukaryotic-type N-acetylglucosamine kinase (NAGK) family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains. Pssm-ID: 466857 [Multi-domain] Cd Length: 295 Bit Score: 127.42 E-value: 3.04e-36
|
|||||||
BadF | COG2971 | BadF-type ATPase, related to human N-acetylglucosamine kinase [Carbohydrate transport and ... |
7-155 | 2.12e-32 | |||
BadF-type ATPase, related to human N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Pssm-ID: 442210 [Multi-domain] Cd Length: 298 Bit Score: 117.29 E-value: 2.12e-32
|
|||||||
ASKHA_NBD_MurK-like | cd24084 | nucleotide-binding domain (NBD) of Clostridium acetobutylicum N-acetylmuramic acid ... |
7-157 | 1.73e-19 | |||
nucleotide-binding domain (NBD) of Clostridium acetobutylicum N-acetylmuramic acid/N-acetylglucosamine kinase (MurK) and similar proteins; The family includes a group of uncharacterized proteins similar to Clostridium acetobutylicum N-acetylmuramic acid/N-acetylglucosamine kinase (MurK; EC 2.7.1.-/EC 2.7.1.59), also known MurNAc/GlcNAc kinase, or murein sugar kinase. It catalyzes the ATP-dependent phosphorylation of both cell wall (peptidoglycan) amino sugars, N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), at the 6-hydroxyl group. Neither the non-N-acetylated forms of the cell wall sugars, i.e., glucosamine and/or muramic acid, nor epimeric hexoses or 1,6-anhydro-MurNAc are substrates for the enzyme. MurK may have a role in the rescue of the murein sugars GlcNAc and MurNAc released from muropeptides during cell wall turnover in C.acetobutylicum. Pssm-ID: 466934 [Multi-domain] Cd Length: 302 Bit Score: 83.18 E-value: 1.73e-19
|
|||||||
ASKHA_NBD_DdNAGK-like | cd24081 | nucleotide-binding domain (NBD) of Dictyostelium discoideum N-acetyl-D-glucosamine kinase ... |
7-155 | 1.00e-18 | |||
nucleotide-binding domain (NBD) of Dictyostelium discoideum N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; The family includes a group of uncharacterized proteins similar to Dictyostelium discoideum N-acetyl-D-glucosamine kinase (NAGK). NAGK (EC 2.7.1.59), also called N-acetylglucosamine kinase, or GlcNAc kinase, converts N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, into GlcNAc 6-phosphate. It also has ManNAc kinase activity. Pssm-ID: 466931 [Multi-domain] Cd Length: 311 Bit Score: 81.21 E-value: 1.00e-18
|
|||||||
ASKHA_NBD_GspK-like | cd24082 | nucleotide-binding domain (NBD) of Vibrio cholerae glucosamine kinase GspK and similar ... |
7-155 | 2.84e-16 | |||
nucleotide-binding domain (NBD) of Vibrio cholerae glucosamine kinase GspK and similar proteins; The family includes a group of uncharacterized proteins similar to Vibrio cholerae glucosamine kinase GspK (EC 2.7.1.8), also called GlcN kinase. It acts as ATP-dependent kinase, which is specific for glucosamine. GspK does not show kinase activity with any other sugar. Pssm-ID: 466932 [Multi-domain] Cd Length: 279 Bit Score: 74.10 E-value: 2.84e-16
|
|||||||
ASKHA_NBD_StHK-like | cd24080 | nucleotide-binding domain (NBD) of Sulfurisphaera tokodaii ATP-dependent hexokinase (StHK) and ... |
7-157 | 5.61e-14 | |||
nucleotide-binding domain (NBD) of Sulfurisphaera tokodaii ATP-dependent hexokinase (StHK) and similar proteins; The family includes a group of uncharacterized proteins similar to Sulfurisphaera tokodaii ATP-dependent hexokinase (StHK). Hexokinase (EC 2.7.1.1) catalyzes the phosphorylation of glucose to glucose 6-phosphate by using ATP as a phosphoryl donor. StHK is a novel hexokinase that can phosphorylate not only glucose but also GlcNAc, glucosamine, and mannose. It differs from other known hexokinases and glucokinases in that its activity is strongly inhibited by ADP. It is distinct in its broad substrate specificity from the GlcNAc kinases, which are specific for GlcNAc. Pssm-ID: 466930 [Multi-domain] Cd Length: 291 Bit Score: 68.22 E-value: 5.61e-14
|
|||||||
BcrAD_BadFG | pfam01869 | BadF/BadG/BcrA/BcrD ATPase family; This family includes the BadF and BadG proteins that are ... |
7-155 | 3.45e-09 | |||
BadF/BadG/BcrA/BcrD ATPase family; This family includes the BadF and BadG proteins that are two subunits of Benzoyl-CoA reductase, that may be involved in ATP hydrolysis. The family also includes an activase subunit from the enzyme 2-hydroxyglutaryl-CoA dehydratase. The protein Swiss:O66634 contains two copies of this region suggesting that the family may structurally dimerize. This family appears to be related to pfam00370. Pssm-ID: 396441 [Multi-domain] Cd Length: 271 Bit Score: 54.28 E-value: 3.45e-09
|
|||||||
ASKHA_NBD_KdgK-like | cd24083 | nucleotide-binding domain (NBD) of Thermoplasma acidophilum 2-dehydro-3-deoxygluconokinase ... |
7-157 | 9.51e-09 | |||
nucleotide-binding domain (NBD) of Thermoplasma acidophilum 2-dehydro-3-deoxygluconokinase (KdgK) and similar proteins; The family includes a group of uncharacterized proteins similar to Thermoplasma acidophilum 2-dehydro-3-deoxygluconokinase (KdgK; EC 2.7.1.45), also called 2-keto-3-deoxy-D-gluconate kinase, or KDG kinase. It catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG). It is specific for KDG. Pssm-ID: 466933 [Multi-domain] Cd Length: 284 Bit Score: 53.16 E-value: 9.51e-09
|
|||||||
ASKHA_NBD_PG1100-like | cd24079 | nucleotide-binding domain (NBD) of Porphyromonas gingivalis putative N-acetylglucosamine ... |
76-155 | 9.61e-07 | |||
nucleotide-binding domain (NBD) of Porphyromonas gingivalis putative N-acetylglucosamine kinase (PG1100) and similar proteins; The family includes a group of uncharacterized proteins similar to Porphyromonas gingivalis putative N-acetylglucosamine kinase (PG1100; EC 2.7.1.59), which may convert GlcNAc to GlcNAc-6-phosphate, a component utilized in UDP-GlcNAc biosynthesis or energy metabolism. Pssm-ID: 466929 [Multi-domain] Cd Length: 276 Bit Score: 47.59 E-value: 9.61e-07
|
|||||||
NagC | COG1940 | Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ... |
1-77 | 3.24e-04 | |||
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription]; Pssm-ID: 441543 [Multi-domain] Cd Length: 306 Bit Score: 39.88 E-value: 3.24e-04
|
|||||||
Blast search parameters | ||||
|