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Conserved domains on  [gi|1958767541|ref|XP_038962803|]
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TP53-regulating kinase (p53-related protein kinase) (Nori-2) isoform X1 [Rattus norvegicus]

Protein Classification

protein kinase family protein( domain architecture ID 229378)

protein kinase family protein may catalyze the transfer of the gamma-phosphoryl group from ATP to substrates such as serine/threonine and/or tyrosine residues on proteins, or may be a pseudokinase

CATH:  1.10.510.10
PubMed:  16244704
SCOP:  4003661

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PKc_like super family cl21453
Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the ...
 31-88 2.16e-19

Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases, and choline kinases. These proteins catalyze the transfer of the gamma-phosphoryl group from ATP to hydroxyl groups in specific substrates such as serine, threonine, or tyrosine residues of proteins.


The actual alignment was detected with superfamily member TIGR03724:

Pssm-ID: 473864 [Multi-domain]  Cd Length: 199  Bit Score: 80.72  E-value: 2.16e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958767541  31 LVQQGAEARVFRGRFQGRAAVVKHRFPKGYRHPELEARLGRRRTVQEARALLRCRRAG 88
Cdd:TIGR03724   1 LIAKGAEAIIYLGDFLGRKAVIKERVPKSYRHPELDERLRKERTRREARLLSRARKAG 58
 
Name Accession Description Interval E-value
arch_bud32 TIGR03724
Kae1-associated kinase Bud32; Members of this protein family are the Bud32 protein associated ...
 31-88 2.16e-19

Kae1-associated kinase Bud32; Members of this protein family are the Bud32 protein associated with Kae1 (kinase-associated endopeptidase 1) in the Archaea. In many Archaeal genomes, Kae1 and Bud32 are fused. The complex is homologous to the Kae1 and Bud32 subunits of the eukaryotic KEOPS complex, an apparently ancient protein kinase-containing molecular machine. [Unknown function, General]


Pssm-ID: 274749 [Multi-domain]  Cd Length: 199  Bit Score: 80.72  E-value: 2.16e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958767541  31 LVQQGAEARVFRGRFQGRAAVVKHRFPKGYRHPELEARLGRRRTVQEARALLRCRRAG 88
Cdd:TIGR03724   1 LIAKGAEAIIYLGDFLGRKAVIKERVPKSYRHPELDERLRKERTRREARLLSRARKAG 58
PRK14879 PRK14879
Kae1-associated kinase Bud32;
29-88 6.91e-19

Kae1-associated kinase Bud32;


Pssm-ID: 237847 [Multi-domain]  Cd Length: 211  Bit Score: 79.57  E-value: 6.91e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958767541  29 LELVQQGAEARVFRGRFQGRAAVVKHRFPKGYRHPELEARLGRRRTVQEARALLRCRRAG 88
Cdd:PRK14879    1 MKLIKRGAEAEIYLGDFLGIKAVIKWRIPKRYRHPELDERIRRERTRREARIMSRARKAG 60
 
Name Accession Description Interval E-value
arch_bud32 TIGR03724
Kae1-associated kinase Bud32; Members of this protein family are the Bud32 protein associated ...
 31-88 2.16e-19

Kae1-associated kinase Bud32; Members of this protein family are the Bud32 protein associated with Kae1 (kinase-associated endopeptidase 1) in the Archaea. In many Archaeal genomes, Kae1 and Bud32 are fused. The complex is homologous to the Kae1 and Bud32 subunits of the eukaryotic KEOPS complex, an apparently ancient protein kinase-containing molecular machine. [Unknown function, General]


Pssm-ID: 274749 [Multi-domain]  Cd Length: 199  Bit Score: 80.72  E-value: 2.16e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958767541  31 LVQQGAEARVFRGRFQGRAAVVKHRFPKGYRHPELEARLGRRRTVQEARALLRCRRAG 88
Cdd:TIGR03724   1 LIAKGAEAIIYLGDFLGRKAVIKERVPKSYRHPELDERLRKERTRREARLLSRARKAG 58
PRK14879 PRK14879
Kae1-associated kinase Bud32;
29-88 6.91e-19

Kae1-associated kinase Bud32;


Pssm-ID: 237847 [Multi-domain]  Cd Length: 211  Bit Score: 79.57  E-value: 6.91e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958767541  29 LELVQQGAEARVFRGRFQGRAAVVKHRFPKGYRHPELEARLGRRRTVQEARALLRCRRAG 88
Cdd:PRK14879    1 MKLIKRGAEAEIYLGDFLGIKAVIKWRIPKRYRHPELDERIRRERTRREARIMSRARKAG 60
PRK09605 PRK09605
bifunctional N(6)-L-threonylcarbamoyladenine synthase/serine/threonine protein kinase;
30-88 2.45e-17

bifunctional N(6)-L-threonylcarbamoyladenine synthase/serine/threonine protein kinase;


Pssm-ID: 236586 [Multi-domain]  Cd Length: 535  Bit Score: 78.01  E-value: 2.45e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958767541  30 ELVQQGAEARVFRGRFQGRAAVVKHRFPKGYRHPELEARLGRRRTVQEARALLRCRRAG 88
Cdd:PRK09605  339 HLIGKGAEADIKKGEYLGRDAVIKERVPKGYRHPELDERLRTERTRAEARLLSEARRAG 397
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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