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Conserved domains on  [gi|1958763261|ref|XP_038961487|]
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voltage-gated purine nucleotide uniporter SLC17A9 isoform X8 [Rattus norvegicus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 38-286 5.46e-92

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17380:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 361  Bit Score: 277.13  E-value: 5.46e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  38 TGMLLLGTCLLYCTRVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVT 117
Cdd:cd17380     1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 118 TPLLAHlgsGHLAFVTFSRILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSV 197
Cdd:cd17380    81 TPLLAY---SSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 198 FYFSGGLTLLWVYYVYKYLLdekdlvlalgvlaqglpvtrpskvpwrqlfrkaSVWAVICSQLSSACSFFILLSWLPTFF 277
Cdd:cd17380   158 FYFFGLLGLLWALVWLIYLP---------------------------------PVWAIIVAHFCMNWGFYILLSWLPTYF 204

                         250
                  ....*....|
gi 1958763261 278 KETF-PHSKA 286
Cdd:cd17380   205 HEVLvPLAKG 214
 
Name Accession Description Interval E-value
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 38-286 5.46e-92

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 277.13  E-value: 5.46e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  38 TGMLLLGTCLLYCTRVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVT 117
Cdd:cd17380     1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 118 TPLLAHlgsGHLAFVTFSRILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSV 197
Cdd:cd17380    81 TPLLAY---SSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 198 FYFSGGLTLLWVYYVYKYLLdekdlvlalgvlaqglpvtrpskvpwrqlfrkaSVWAVICSQLSSACSFFILLSWLPTFF 277
Cdd:cd17380   158 FYFFGLLGLLWALVWLIYLP---------------------------------PVWAIIVAHFCMNWGFYILLSWLPTYF 204

                         250
                  ....*....|
gi 1958763261 278 KETF-PHSKA 286
Cdd:cd17380   205 HEVLvPLAKG 214
MFS_1 pfam07690
Major Facilitator Superfamily;
41-279 1.35e-29

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 114.82  E-value: 1.35e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  41 LLLGTCLLYCTR-VTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFitvtTP 119
Cdd:pfam07690   1 LFLAAFLAALGRsLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFAL----GL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 120 LLAHLGSGHLAFVtFSRILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFY 199
Cdd:pfam07690  77 LLLLFASSLWLLL-VLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 200 FSGGLTLLWVYYVYkYLLDEKDLVLALGVLAQGLPVTrpskVPWRQLFRKASVWAVICSqLSSACSFFILLSWLPTFFKE 279
Cdd:pfam07690 156 ILAILSLLAAVLLL-LPRPPPESKRPKPAEEARLSLI----VAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLYQEV 229
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
39-287 1.29e-28

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 112.66  E-value: 1.29e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  39 GMLLLGTCLLYCTRVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTT 118
Cdd:COG2271    13 ALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 119 PLlahlgSGHLAFVTFSRILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVF 198
Cdd:COG2271    93 GF-----ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAF 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 199 YFSGGLTLLWVYyvykylldekdlvlalgvlaqglpvtrpskvpwrqlfrkASVWAVICSQLSSACSFFILLSWLPTFFK 278
Cdd:COG2271   168 LILGLPGLLLAL---------------------------------------LRFWLLALAYFLVYFALYGFLTWLPTYLV 208


                  ....*....
gi 1958763261 279 ETFPHSKAQ 287
Cdd:COG2271   209 EVRGLSLAQ 217
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 43-281 3.49e-23

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 98.18  E-value: 3.49e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  43 LGTCLLYCTRVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTTPLLA 122
Cdd:TIGR00893   1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 123 HLGSGHLAfvtfsRILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFYFSG 202
Cdd:TIGR00893  81 AYVSLYIL-----RVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 203 GLTLLWVYYVYKYLLDEKD------------LVLALGVLAQGLPVTRPSKVPWRQLFRKASVWAVICSQLSSACSFFILL 270
Cdd:TIGR00893 156 VLGIIWGVLWLKFIPDPPQkakwlteeekyiVVGGLLAEQQGKGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFFL 235

                         250
                  ....*....|.
gi 1958763261 271 SWLPTFFKETF 281
Cdd:TIGR00893 236 TWFPTYLVQER 246
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 57-274 1.85e-12

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 66.91  E-value: 1.85e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  57 VCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTTPLLAHLGSghLAFVtfsR 136
Cdd:PRK11551   36 VAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS--LLVA---R 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 137 ILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFYFSGGLTLLWVYYVYKYL 216
Cdd:PRK11551  111 LLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWL 190

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958763261 217 LDEKDLVLALGVLAQGLPVtrpskvpWRQLFRKASVWAVICSQLSSACS---FFILLSWLP 274
Cdd:PRK11551  191 PESRAFAQAAGAGKQRAPV-------LRALFGEGRATATLLLWISYFFTlivLYFLLNWLP 244
 
Name Accession Description Interval E-value
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 38-286 5.46e-92

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 277.13  E-value: 5.46e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  38 TGMLLLGTCLLYCTRVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVT 117
Cdd:cd17380     1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 118 TPLLAHlgsGHLAFVTFSRILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSV 197
Cdd:cd17380    81 TPLLAY---SSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 198 FYFSGGLTLLWVYYVYKYLLdekdlvlalgvlaqglpvtrpskvpwrqlfrkaSVWAVICSQLSSACSFFILLSWLPTFF 277
Cdd:cd17380   158 FYFFGLLGLLWALVWLIYLP---------------------------------PVWAIIVAHFCMNWGFYILLSWLPTYF 204

                         250
                  ....*....|
gi 1958763261 278 KETF-PHSKA 286
Cdd:cd17380   205 HEVLvPLAKG 214
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 38-281 1.77e-64

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 207.47  E-value: 1.77e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  38 TGMLLLGTCLLYCTRVTMPVCTVAMSQ----------------------DFGWNKKEAGIVLSSFFWGYCLTQVVGGHLG 95
Cdd:cd17318     1 AILLFLGFAVVYAMRVNLSVAIVAMVNstathdnnntstdkdtlpveapEFDWSEKTQGIILSSFFYGYILTQIPGGYLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  96 DRIGGEKVILLSASAWGFITVTTPLLAHlgsGHLAFVTFSRILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQ 175
Cdd:cd17318    81 EKYGAKRVLGYSILITALLTLLTPLAAR---GGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQ 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 176 VGTLVTGGIGSVLLDRCGWQSVFYFSGGLTLLWVYYVYKylldekdLVLAlgvlaqglpvtrpskvpwrqlfrkasVWAV 255
Cdd:cd17318   158 FGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFF-------LVLP--------------------------VWAI 204

                         250       260
                  ....*....|....*....|....*.
gi 1958763261 256 ICSQLSSACSFFILLSWLPTFFKETF 281
Cdd:cd17318   205 VVAHFGHNWGFYTLLTELPTYMSDVL 230
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 39-284 3.89e-30

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 116.52  E-value: 3.89e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  39 GMLLLGTCLLYCTRVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTT 118
Cdd:cd17319     6 PLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 119 PLLahlgSGHLAFVTFsRILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVF 198
Cdd:cd17319    86 GFA----TSLTSLYVL-RFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 199 YFSGGLTLLWVyyvykylldekdlvlalgvlaqglpvtrpskVPWRQLFRkaSVWAVICSQLSSACSFFILLSWLPTFFK 278
Cdd:cd17319   161 IIEGLLGLLLA-------------------------------VLWWFYLR--QVWGLALGYFGINYALYGLLTWLPTYLK 207


                  ....*.
gi 1958763261 279 ETFPHS 284
Cdd:cd17319   208 QARGFS 213
MFS_1 pfam07690
Major Facilitator Superfamily;
41-279 1.35e-29

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 114.82  E-value: 1.35e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  41 LLLGTCLLYCTR-VTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFitvtTP 119
Cdd:pfam07690   1 LFLAAFLAALGRsLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFAL----GL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 120 LLAHLGSGHLAFVtFSRILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFY 199
Cdd:pfam07690  77 LLLLFASSLWLLL-VLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 200 FSGGLTLLWVYYVYkYLLDEKDLVLALGVLAQGLPVTrpskVPWRQLFRKASVWAVICSqLSSACSFFILLSWLPTFFKE 279
Cdd:pfam07690 156 ILAILSLLAAVLLL-LPRPPPESKRPKPAEEARLSLI----VAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLYQEV 229
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
39-287 1.29e-28

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 112.66  E-value: 1.29e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  39 GMLLLGTCLLYCTRVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTT 118
Cdd:COG2271    13 ALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 119 PLlahlgSGHLAFVTFSRILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVF 198
Cdd:COG2271    93 GF-----ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAF 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 199 YFSGGLTLLWVYyvykylldekdlvlalgvlaqglpvtrpskvpwrqlfrkASVWAVICSQLSSACSFFILLSWLPTFFK 278
Cdd:COG2271   168 LILGLPGLLLAL---------------------------------------LRFWLLALAYFLVYFALYGFLTWLPTYLV 208


                  ....*....
gi 1958763261 279 ETFPHSKAQ 287
Cdd:COG2271   209 EVRGLSLAQ 217
MFS_SLC17A5 cd17381
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ...
 40-279 4.98e-25

Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340939 [Multi-domain]  Cd Length: 397  Bit Score: 103.32  E-value: 4.98e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  40 MLLLGTCLLYCTRVTMPVCTVAM------------------------------SQDFGWNKKEAGIVLSSFFWGYCLTQV 89
Cdd:cd17381     4 LAFFGFFVVYALRVNLSVALVDMvnsnstlpsnnssnacpehssspsvehnetGKKYDWDAETQGWILGSFFYGYIITQI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  90 VGGHLGDRIGGEKVILLSASAWGFITVTTPLLAHLGSGHLAFVtfsRILTGLLQGVYFPALTSLLSQRVQESERSFTYST 169
Cdd:cd17381    84 PGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAV---RALEGLGEGVTFPAMHAMWASWAPPLERSRLLTI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 170 VGAGSQVGTLVTGGIGSVLLDRCGWQSVFYFSGGLTLLW-VYYVYkylldekdLVLALgvlaqglpvtrpskvpwrqlfr 248
Cdd:cd17381   161 SYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWfFLWIW--------LVMPL---------------------- 210

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1958763261 249 kasvWAVICSQLSSACSFFILLSWLPTFFKE 279
Cdd:cd17381   211 ----WAIVVAHFSYNWTFYTLLTLLPTYMKE 237
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 43-281 3.49e-23

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 98.18  E-value: 3.49e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  43 LGTCLLYCTRVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTTPLLA 122
Cdd:TIGR00893   1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 123 HLGSGHLAfvtfsRILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFYFSG 202
Cdd:TIGR00893  81 AYVSLYIL-----RVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 203 GLTLLWVYYVYKYLLDEKD------------LVLALGVLAQGLPVTRPSKVPWRQLFRKASVWAVICSQLSSACSFFILL 270
Cdd:TIGR00893 156 VLGIIWGVLWLKFIPDPPQkakwlteeekyiVVGGLLAEQQGKGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFFL 235

                         250
                  ....*....|.
gi 1958763261 271 SWLPTFFKETF 281
Cdd:TIGR00893 236 TWFPTYLVQER 246
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
61-287 5.21e-23

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 96.97  E-value: 5.21e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  61 AMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTTPLlahlgSGHLAFVTFSRILTG 140
Cdd:COG2814    35 LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL-----APSLWLLLAARFLQG 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 141 LLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFYFSGGLTLLWvyyvykylldek 220
Cdd:COG2814   110 LGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLA------------ 177

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958763261 221 dLVLALGVLAQGLPVTRPS-KVPWRQLFRKASVWAVICSQLSSACSFFILLSWLPTFFKETFPHSKAQ 287
Cdd:COG2814   178 -LLLLLRLLPESRPAARARlRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASA 244
MFS_SLC17A6_7_8_VGluT cd17382
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ...
 40-281 3.13e-22

Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340940 [Multi-domain]  Cd Length: 380  Bit Score: 95.10  E-value: 3.13e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  40 MLLLGTCLLYCTRVTMPVCTVAM---------------SQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVI 104
Cdd:cd17382     3 MAGLGFCISFGIRCNLGVAIVRMvnnftdayggkvivhKAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 105 LLSASAWGFITVTTPLLAHLgsgHLAFVTFSRILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGI 184
Cdd:cd17382    83 GLAIFVTSTLNMLIPIAARV---HYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 185 GSVLLDRCGWQSVFYFSGGLTLLWvyYVYKYLldekdlvlalgvlaqglpVTRPskvpwrqlfrkasVWAVICSQLSSAC 264
Cdd:cd17382   160 SGILVQYVGWSSPFYVYGVFGIIW--YMFWML------------------VSMP-------------VYAIIVANFCRSW 206

                         250
                  ....*....|....*..
gi 1958763261 265 SFFILLSWLPTFFKETF 281
Cdd:cd17382   207 TFYLLLISQPAYFKEVF 223
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
35-287 7.34e-20

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 88.78  E-value: 7.34e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  35 QLWTGMLLLGTCllYCTRVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFi 114
Cdd:COG2223     6 VLLLATLAFFLA--FGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 115 tvttPLLAHLGSGHLAFVTFSRILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGW 194
Cdd:COG2223    83 ----GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGW 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 195 QSVFYFSGGLTLLWVYYVYKYLLDEKdlvlalgvlAQGLPVTRPSKVPWRQLFRKASVWAVICSQLSSACSFFILLSWLP 274
Cdd:COG2223   159 RNAFLILGILLLVVAVLAWLFLRDPP---------AGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLP 229

                         250
                  ....*....|...
gi 1958763261 275 TFFKETFPHSKAQ 287
Cdd:COG2223   230 PYLVDQFGLSAAT 242
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 64-287 5.38e-18

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 83.01  E-value: 5.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  64 QDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSAsawgFITVTTPLLAHLgSGHLAFVTFSRILTGLLQ 143
Cdd:cd17325    24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGL----LLLAVSTLLFAF-ATSYWQLLLARFLQGLAS 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 144 GVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFYFSGGLTLLwvyyvykylldekDLV 223
Cdd:cd17325    99 AAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALL-------------ALV 165

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958763261 224 LALGVL-------AQGLPVTRPSKVPWRQLFRKASVWAVICSQLSSACSFFILLSWLPTFFKETFPHSKAQ 287
Cdd:cd17325   166 LALLLLpeprpppNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQ 236
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 66-280 1.83e-15

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 76.32  E-value: 1.83e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  66 FGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVIllsASAWGFITVTTPLLAHLGSGHLAFVTFSRILTGLLQGV 145
Cdd:TIGR00894  71 FKWSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSI---GIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGS 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 146 YFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLD-RCGWQSVFYFSG----GLTLLWVYYVY----KYL 216
Cdd:TIGR00894 148 VSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCEsWGGWPMIFYVFGivgcAWSLLWFVFPAddpsIHP 227

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958763261 217 LDEKDLVLALGVLAQGLPVTRPSKVPWRQLFRKASVWAVICSQLSSACSFFILLSWLPTFFKET 280
Cdd:TIGR00894 228 CISKFEKKYINSSLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWV 291
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 61-277 4.78e-15

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 73.69  E-value: 4.78e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  61 AMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTTPLlahlgSGHLAFVTFSRILTG 140
Cdd:COG0477    39 SIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGL-----APSPELLIAARALQG 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 141 LLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFYFSGGLTLLWVYYVYKyLLDEK 220
Cdd:COG0477   114 IGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLR-LPESR 192

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958763261 221 DLVLALGVLAQGLPVTRPSKVPWRQLFRKASVWAVICSQLSSACSFFILLSWLPTFF 277
Cdd:COG0477   193 GLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLA 249
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 43-288 4.10e-14

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 71.92  E-value: 4.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  43 LGTCLLYCTRVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLsasawGFITVttpLLA 122
Cdd:cd17312    10 LGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSA-----GLLLS---ALA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 123 HLGSG---HLAFVTFSRILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFY 199
Cdd:cd17312    82 NIFMGfstSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 200 FSGGLTLLWVYYVYKYLLDEKDLVLALGvlaqglpvtrpskvpwrqlfrkasvwavicsqLSSACSF---FILLSWLPTF 276
Cdd:cd17312   162 VPGIVGLVVAIILFFFLRDSPPYVWVLS--------------------------------LAYAFVYivrYACLDWGPLY 209

                         250
                  ....*....|..
gi 1958763261 277 FKETFPHSKAQP 288
Cdd:cd17312   210 LYEVKGYSLIDA 221
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 62-207 9.70e-14

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 70.68  E-value: 9.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  62 MSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSasaWGFITVTTPLLAHLGSGHLAFVTFsrILTGL 141
Cdd:cd17325   226 AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIG---LLLSAVALLLLPLATSFWLLLLLL--ALLGL 300

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958763261 142 LQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFYFSGGLTLL 207
Cdd:cd17325   301 GLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLL 366
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 61-284 1.41e-13

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 70.27  E-value: 1.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  61 AMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTTPLlahlgSGHLAFVTFSRILTG 140
Cdd:cd17324    24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAAL-----APSFALLLLARALAG 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 141 LLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFYFSGGLTLlwvyyvykylldek 220
Cdd:cd17324    99 LAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLAL-------------- 164

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958763261 221 dlvLALGVLAQGLPVTRPSKVP-------WRQLFRKASVWAVICSQLSSACSFFILLSWLPTFFKETFPHS 284
Cdd:cd17324   165 ---LAALLLWRLLPSLPPKKPGslgllssLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFS 232
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 61-280 2.56e-13

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 69.69  E-value: 2.56e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  61 AMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITvttpLLAHLGSGHLAFVTFsRILTG 140
Cdd:TIGR00895  42 AISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFT----LLCALATNVTQLLIL-RFLAG 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 141 LLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFYFSGGLTLLWVYYVYKYL---- 216
Cdd:TIGR00895 117 LGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLpesi 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 217 --LDEKDLVLALGVLAQGLPVTRPS---------------KVPWRQLFRKASVWAVICSQLSSAC---SFFILLSWLPTF 276
Cdd:TIGR00895 197 dfLVSKRPETVRRIVNAIAPQMQAEaqsalpeqkstqgtkRSVFKALFQGKTARITVLLWLLYFMllvGVYFLTNWLPKL 276


                  ....
gi 1958763261 277 FKET 280
Cdd:TIGR00895 277 MVEL 280
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 41-288 2.64e-13

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 69.38  E-value: 2.64e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  41 LLLGTCLLYCTRVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVttpL 120
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGAL---L 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 121 LAhlGSGHLAFVTFSRILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRC--GWQSVF 198
Cdd:cd06174    78 FA--FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVF 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 199 YFSGGLTLLWVYYVYKYLLDEKDLVLALGVLAQglpvTRPSKVPWRQLFRKASVWAVICSQLSSACSFFILLSWLPTFFK 278
Cdd:cd06174   156 LIAAALALLAAILLLLVVPDPPESARAKNEEAS----SKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLL 231

                         250
                  ....*....|
gi 1958763261 279 ETFPHSKAQP 288
Cdd:cd06174   232 DLGGLSVAVA 241
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 57-274 1.85e-12

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 66.91  E-value: 1.85e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  57 VCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTTPLLAHLGSghLAFVtfsR 136
Cdd:PRK11551   36 VAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS--LLVA---R 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 137 ILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFYFSGGLTLLWVYYVYKYL 216
Cdd:PRK11551  111 LLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWL 190

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958763261 217 LDEKDLVLALGVLAQGLPVtrpskvpWRQLFRKASVWAVICSQLSSACS---FFILLSWLP 274
Cdd:PRK11551  191 PESRAFAQAAGAGKQRAPV-------LRALFGEGRATATLLLWISYFFTlivLYFLLNWLP 244
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 61-207 2.13e-11

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 63.76  E-value: 2.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  61 AMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTTPLlahlgSGHLAFVTFSRILTG 140
Cdd:cd17365    24 ALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAF-----AQSVLQLALLRFLTG 98

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958763261 141 LLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFYFSGGLTLL 207
Cdd:cd17365    99 LGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLI 165
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
62-207 1.01e-10

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 61.81  E-value: 1.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  62 MSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAwGFITVTTPLLAHLGSGHLAFVTFsrILTGL 141
Cdd:COG2271   207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGL-LLAALALLLLALLPSPALAIALL--FLAGF 283

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958763261 142 LQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFYFSGGLTLL 207
Cdd:COG2271   284 GLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALL 349
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
61-281 6.08e-09

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 56.40  E-value: 6.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  61 AMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSAsawGFITVTTPLLAHLGSghLAFVTFSRILTG 140
Cdd:COG0738    33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL---LLMALGLLLFALAPS--YPLLLLALFLLG 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 141 LLQGVYFPALTSLLSQRVQESERSFTySTVGAGSQVGTLVTGGIGSVLLDR---CGWQSVFYFSGGLTLLWVYYVYKYLL 217
Cdd:COG0738   108 LGLGLLDVAANPYVAALGPETAASRL-NLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFLRSKL 186

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958763261 218 DEkdlvlalgvLAQGLPVTRPSKVPWRQLFRKASVWAVICSQLSSACSFFILLSWLPTFFKETF 281
Cdd:COG0738   187 PE---------IEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVL 241
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 36-282 1.43e-08

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 55.31  E-value: 1.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  36 LWTGMLLLGTCllycTRVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFIT 115
Cdd:cd17329     4 LLIGSFLNRLG----FFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 116 VttpLLAHLGSGHLAFVTFsrILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDrcgwq 195
Cdd:cd17329    80 A---LLGFAHSPWLFAIAL--VLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL----- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 196 svfyfsggltllwVYYVYKYLLDEKDLVLALGVLAQGLPVTRP---------SKVPWRQLFRKASVWAVICSQLSSACSF 266
Cdd:cd17329   150 -------------YSFRLLFLAAAVLFLLAALVLLFLLPETRPkrraaekteILRGYKIVLRDRAFLLFLLASFLISLIY 216

                         250
                  ....*....|....*.
gi 1958763261 267 FILLSWLPTFFKETFP 282
Cdd:cd17329   217 FQLESTLPVYVVEILG 232
MFS_1 pfam07690
Major Facilitator Superfamily;
11-180 5.22e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 53.58  E-value: 5.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  11 PIPEETRKTPSAAAEDKRWSRPECQLWTGMLLLGTCLLYCTrVTMPVctvaMSQDFGWNKKEAGIVLSSFFWGYCLTQVV 90
Cdd:pfam07690 180 PKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLL-TYLPL----YQEVLGLSALLAGLLLGLGGLLGAIGRLL 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  91 GGHLGDRIGGEKVILLSASAWGFITVTTPLLAHLGSGHLAFVTFsrILTGLLQGVYFPALTSLLSQRVQESERSFTYSTV 170
Cdd:pfam07690 255 LGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLAL--LLLGFGFGLVFPALNALVSDLAPKEERGTASGLY 332

                         170
                  ....*....|
gi 1958763261 171 GAGSQVGTLV 180
Cdd:pfam07690 333 NTAGSLGGAL 342
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 62-284 1.06e-07

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 52.64  E-value: 1.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  62 MSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTTPLLAHLGSghlaFVTFsRILTGL 141
Cdd:cd17327    32 MKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGG----LIAL-RFFLGL 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 142 LQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDR------CGWQSVFYFSGGLTLLWVYYV--- 212
Cdd:cd17327   107 FESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKIlgvgglAGWRWLFIIEGLITIIIGLVIffw 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 213 ------YKYLLDEKDLVLALGVLA---QGLPVTRPSKVPWRQLFRKASVWAVICSQLSSACSFFILLSWLPTFFKETFPH 283
Cdd:cd17327   187 lpdnpsKAWFLTEEEKELAVERLRanqTGKGDQKFKWKQIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKSLGFY 266


                  .
gi 1958763261 284 S 284
Cdd:cd17327   267 S 267
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
66-214 1.12e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 52.58  E-value: 1.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  66 FGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILlsASAWGFITVTTPLLAHLGSGHLAFVTFsrILTGLLQGV 145
Cdd:COG2223   236 FGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLL--IVFALMALGLLLLALALGSLWLFLVLF--LLLGLALGG 311

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958763261 146 YFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCG-WQSVFYFSGGL---TLLWVYYVYK 214
Cdd:COG2223   312 GNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLalvALVLTLLLYR 384
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 41-263 1.20e-07

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 52.27  E-value: 1.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  41 LLLGTCLLYCT----RVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITV 116
Cdd:cd17355     4 VLAVTFLILILswgiRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 117 TTPLLAHLGSGHLAFVtfsrILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQS 196
Cdd:cd17355    84 LLALATSLWQLYLLWG----LLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRT 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958763261 197 VFYFSGGLTLLWVYYVYKYLLDEKDLvlaLGVLAQGLPVTRPSKVPWRQLFRKASVWAVICSQLSSA 263
Cdd:cd17355   160 ALLVLALLALLVLVPVLLLLRRRPAD---LALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCG 223
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
61-277 1.64e-07

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 52.18  E-value: 1.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  61 AMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSAsawGFITVTTPLLAHLGSGHLAFVtfSRILTG 140
Cdd:COG2807    43 EIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLAL---LLLAAGLLLRSLAPSVALLLA--GTALIG 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 141 LLQGVYFPALTSLLSQRVQESeRSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFYFSGGLTLLwvyyvykylldek 220
Cdd:COG2807   118 AGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALL------------- 183

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 221 dLVLALGVLAQGLPVTR---PSKVPWRQLFRKASVWAVICSQLSSACSFFILLSWLPTFF 277
Cdd:COG2807   184 -ALLLWLPLLRRRPAAAaaaPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPIL 242
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
11-177 2.15e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 51.51  E-value: 2.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  11 PIPEETRKTPSAAAEDKRWSRPECQLWTGMLLLGTCLLYCTRVTMPVctvAMSQDFGWNKKEAGIVLSSFFWGYCLTQVV 90
Cdd:COG2814   186 PESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPL---YLQEVLGLSASAAGLLLALFGLGGVLGALL 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  91 GGHLGDRIGGEKVILlsasaWGFITVTTPLLAHLGSGHLAFVTFSRILTGLLQGVYFPALTSLLSQRVQESERSFTYSTV 170
Cdd:COG2814   263 AGRLADRFGRRRLLL-----IGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLY 337


                  ....*..
gi 1958763261 171 GAGSQVG 177
Cdd:COG2814   338 NSAFFLG 344
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 73-216 5.18e-07

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 50.27  E-value: 5.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  73 AGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSasawgFITVTTPLLAHLGSGHLAFVTFSRILTGLLqGVYFPALTS 152
Cdd:cd17330    36 VGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLS-----LAGSAVSYVLLGLSRNLWLLFLARFLDGLT-GGNVSVAQA 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958763261 153 LLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFYFSGGLTLLWVYYVYKYL 216
Cdd:cd17330   110 YIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFL 173
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 43-219 7.67e-07

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 50.07  E-value: 7.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  43 LGTCLLYCTRVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGgeKVILLSAsawGFITVTTPLLA 122
Cdd:TIGR00881   2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSN--PRVFLPI---GLILCAIVNLF 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 123 HLGSGHLAFVTFSRILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQV-GTLVTGGIGSVLLDRCGWQSVFYFS 201
Cdd:TIGR00881  77 FGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVgGGLLPPLVLFGIAELYSWHWVFIVP 156

                         170
                  ....*....|....*...
gi 1958763261 202 GGLTLLWVYYVYKYLLDE 219
Cdd:TIGR00881 157 GIIAIIVSLICFLLLRDS 174
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 61-280 8.68e-07

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 49.99  E-value: 8.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  61 AMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLsasawgfitvtTPLLAHLGSGHLAFVT------F 134
Cdd:cd17371    24 ALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVI-----------TILLFAVFTLLCGFAQnywqllI 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 135 SRILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVG----TLVTGGIGSVLLDRCGWQSVFYFsGGLTLLWVY 210
Cdd:cd17371    93 LRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGwllaTLLAALLFPLLPPEIAWRVLFLL-GALPALLVL 171

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958763261 211 YVYKYLLDEkdlvlALGVLAQGLPVTRPSKVPWRQLFRKASVWAVICSQLSSACSFFI---LLSWLPTFFKET 280
Cdd:cd17371   172 FIRRFVKEP-----PQWQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGyygITTWLPSYLTGE 239
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 39-281 9.43e-07

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 49.54  E-value: 9.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  39 GMLLLGTCLLYCTRVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTT 118
Cdd:cd17328     2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 119 PLlahlgSGHLAFVTFSRILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRC-GWQSV 197
Cdd:cd17328    82 SF-----APNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 198 FYFSGGLTLLWVYYVYKYLLDEKDLVLALGVLAqgLPVTRPSKVPWRQLFRKASVWaviCSQLSSACSFFI---LLSWLP 274
Cdd:cd17328   157 FRVTGVLGVLLAILLLLFVREPPRGAAEGGVMA--KSTATSFLADLKALAKNPSFI---LSTLGFTAVSFVtgaLAFWAP 231


                  ....*..
gi 1958763261 275 TFFKETF 281
Cdd:cd17328   232 TFFLRAF 238
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 73-254 9.68e-07

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 49.57  E-value: 9.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  73 AGIVLSSFFWGYCLTQVVGGHLGDRIGgEKVILLSASAWGFITVTTpllahlgsghLAFVT------FSRILTGLLQGvY 146
Cdd:cd17391    38 SGLAFSSTFLVSAIFSPIWGRLADRYG-RKPMLLRASLGMAIVIGL----------MAFVTnvwqllILRLLQGVFSG-Y 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 147 FPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFYFSGGLTLLWVyyvykylldekdLVLAL 226
Cdd:cd17391   106 VPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAF------------LLTLF 173

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1958763261 227 GVLAQGLPVTR----PSKVPWRQLFRKASVWA 254
Cdd:cd17391   174 FVKEDFKPVEKkkmvSTKEVWNSVPNPSLLIS 205
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 38-217 9.78e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 49.52  E-value: 9.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  38 TGMLLLGTCLLYCTRVTMPVCTVAMSQDFGWN--KKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFIT 115
Cdd:cd17316     1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGlsLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 116 VTTPLLahlgSGHLAFVTFsRILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRC--- 192
Cdd:cd17316    81 LLIGLL----PTPILLLVL-RFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgd 155

                         170       180
                  ....*....|....*....|....*.
gi 1958763261 193 -GWQSVFYFSGGLTLLwVYYVYKYLL 217
Cdd:cd17316   156 wGWRILFLIGALPALL-ALLLRRRTL 180
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 61-207 2.44e-06

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 48.32  E-value: 2.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  61 AMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLS------ASAWGFITVTTPLLahlgsghlafvTF 134
Cdd:cd17321    21 TIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGlalfglASLLCALAPSLAFL-----------IA 89

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958763261 135 SRILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFYFSGGLTLL 207
Cdd:cd17321    90 ARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLV 162
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 56-281 2.62e-06

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 48.39  E-value: 2.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  56 PVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLsasawGFITVTTPLLAHLGSGHLAFVTFS 135
Cdd:cd17475    16 PALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAV-----GLLLMGAAALLMALVGSYPVLLVL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 136 RILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGtlvtGGIGSVLL----DRCGWQSVFYFSGGLTLLWVYY 211
Cdd:cd17475    91 LFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLG----GALAAALLpplaLHYGWRAAFVVAGLVSILAAVL 166

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 212 VYKYLLDEKDlvlalGVLAQGLPVTRPSKVpwRQLFRKASVWAVICSQLSSACSFFILLSWLPTFFKETF 281
Cdd:cd17475   167 FWLFYREPPA-----ASAATESASTLLRSL--KEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHL 229
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 61-287 2.79e-06

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 48.34  E-value: 2.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  61 AMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAwgFItVTTPLLAHlgSGHLAFVTFSRILTG 140
Cdd:cd17320    24 AIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLL--FI-LASLLCAL--ASSIEQLLIARFLQG 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 141 LlqGVYFPALT--SLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFYFSGGLTLLWVYYVYKYlLD 218
Cdd:cd17320    99 L--GAAAGSVVarAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLF-LP 175

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 219 EKDLVLALGVLAQGLPVTrpskvpWRQLFRKASVWA-VICSQLSSAcSFFILLSWLPTFFKETFPHSKAQ 287
Cdd:cd17320   176 ETLPEEKRKPLLSSLLRA------YKRVLKNRRFLGyALALGLSFA-GLFAYLAAAPFIYIEQLGLSPAQ 238
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 18-207 3.07e-06

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 47.92  E-value: 3.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  18 KTPSAAAEDKRWSRPECQLWtgMLLLGTCLLYCTRVTMPVcTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDR 97
Cdd:cd17370   184 PKLRKKSKKTSLKKLPKAFW--LYLLAVALFALGNFSFAF-LILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDR 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  98 IGGEKVILLSASAWGFItvttpLLAHLGSGHLAFVTFSRILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVG 177
Cdd:cd17370   261 IGRKKLLILGYLSLALA-----YLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIG 335

                         170       180       190
                  ....*....|....*....|....*....|
gi 1958763261 178 TLVTGGIGSVLLDRCGWQSVFYFSGGLTLL 207
Cdd:cd17370   336 WLLASLIAGYLWDLISPSAAFLFSAVLALI 365
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
5-214 3.18e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 47.93  E-value: 3.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261   5 RSSLMQPIPEETRKTPSAAAEDKRWSRPecQLWTGMLLLgtcLLYC-TRVTMPV-CTVAMSQDFGWNKKEAGIVLSSFFW 82
Cdd:COG0738   183 RSKLPEIEEEEEEAAGSAASLKSLLKNP--RLLLGGLAI---FLYVgAEGAIGDwLPLYLKDVLGLSEATAALGLSLFWG 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  83 GYCLTQVVGGHLGDRIGGEKVILLSAsawGFITVTTPLLAHLGSGHLAFVTFsrILTGLLQGVYFPALTSLLSQRVQESe 162
Cdd:COG0738   258 GMTIGRFLGGFLLKRFGPVRLLRLSA---LLAAVGLLLALLAPGPWLALIGL--ALVGLGLSLMFPTIFSLALDGLGKR- 331

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958763261 163 RSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFYFSGGLTLLWVYYVYK 214
Cdd:COG0738   332 TAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALA 383
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 39-207 3.56e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 47.97  E-value: 3.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  39 GMLLLGTCLLYCTRVTMpvcTVAMSQDFGWnkKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSAsawGFITVTT 118
Cdd:cd17489   200 ALILFLASIAYGAISTF---LPLYAAERGI--SNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGL---LLLALGL 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 119 PLLAHLGSGHLAFVTFsrILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVF 198
Cdd:cd17489   272 LLLSFAGSPWMLLLAA--VLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMF 349


                  ....*....
gi 1958763261 199 YFSGGLTLL 207
Cdd:cd17489   350 LLAAVVVLL 358
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 11-207 5.40e-06

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 47.18  E-value: 5.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  11 PIPEETRKTPSAAAEDKRWSRPECQLWTGMLLLGTC----LLYCTRVTMPVctvAMSQDFGWNKKEAGIVLSSFFWGYCL 86
Cdd:cd17474   173 LPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFlyffLYFAFLTYLPF---LLELLYGISPIIIGLLFAGWSVLLAL 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  87 TQVVGGH-LGDRIGGEKVILLSASAWGFITVTTPLLahlgsGHLAFVTFSRILTGLLQGVYFPALTSLLSQRVQESERSF 165
Cdd:cd17474   250 GSLFVGRlLKKRFGARRILVIGLLLYALSLLLLGFV-----PSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGT 324

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1958763261 166 TYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFYFSGGLTLL 207
Cdd:cd17474   325 ASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALA 366
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 40-207 6.31e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 47.22  E-value: 6.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  40 MLLLGTCLLYCTRVTMPVCTVAMSQD-FGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGfitVTT 118
Cdd:cd06173   212 LLLLALALFALLGGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLG---LAL 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 119 PLLAHLGSGHLAFVTFsrILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVF 198
Cdd:cd06173   289 LVLGLSPSLWLLLAAL--FLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVF 366


                  ....*....
gi 1958763261 199 YFSGGLTLL 207
Cdd:cd06173   367 LLAGALLLL 375
MFS_UhpC cd17488
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ...
 41-207 9.25e-06

Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341041 [Multi-domain]  Cd Length: 364  Bit Score: 46.63  E-value: 9.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  41 LLLGTCLLYCTRVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVttpl 120
Cdd:cd17488     8 MFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINI---- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 121 LAHLGSGHLAFvTFSRILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFYF 200
Cdd:cd17488    84 LFGFSSSLWAF-AVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGMYV 162


                  ....*..
gi 1958763261 201 SGGLTLL 207
Cdd:cd17488   163 PGIIAIL 169
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 64-279 2.31e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 45.28  E-value: 2.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  64 QDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLsasawGFITVTTPLLAHLGSGHLAFVTFSRILTGLLQ 143
Cdd:cd17489    24 HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLI-----GLLIFALATLLYLLATSVALLLVLRLIHGIGW 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 144 GVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFYFSGGLTLLwvyyvykylldekDLV 223
Cdd:cd17489    99 GAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALL-------------ALL 165

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958763261 224 LALGVLAQGLPV---TRPSKVPWRQLFRKaSVWAVICSQLSSACSFFILLSWLPTFFKE 279
Cdd:cd17489   166 LVFLVKDPPPVAaeeAEAGTRAFRRLVEK-KVLPPALILFLASIAYGAISTFLPLYAAE 223
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 73-216 4.14e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 44.56  E-value: 4.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  73 AGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLsASAWGFITVTTPLLAHLGSGHLAFvtfsRILTGLLQGVYFPALTS 152
Cdd:cd17391   242 SGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLG-ALLASALLYIPQAFVQTPWQLGIL----RFLLGLATGGLLPAINS 316

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958763261 153 LLSQRVQESE--RSFTYSTVGA--GSQVGTLVTGGIGSVLldrcGWQSVFYFSGGLTLLWVYYVYKYL 216
Cdd:cd17391   317 LLAKITPKEVagRIFGYNQSFQylGNVAGPLLGSAIAAHF----GYRAVFVVTALLVLLNAIWSFIFL 380
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
37-196 4.39e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 44.51  E-value: 4.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  37 WTGMLLLGTCLLYctrvtmpvctvAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITV 116
Cdd:COG2211   241 FLALALVAALLLY-----------YFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLL 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 117 ttpLLAHLGSGHLAFVTFSRILTGLLQGVYFPALTSLLSQRVQESE-------RSFTYSTVGAGSQVGTLVTGGIGSVLL 189
Cdd:COG2211   310 ---LLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAGLLL 386


                  ....*..
gi 1958763261 190 DRCGWQS 196
Cdd:COG2211   387 ALFGYVA 393
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 8-207 1.22e-04

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 42.98  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261   8 LMQPIPEETRKTPSAAAEDKR----WSRPECQLWTGMLLLGTCLLYCTRVTMpvCTVAMSQdFGWNKKEAGIVLSSFFWG 83
Cdd:cd17490   166 LSLFIKEERREKKPVLTELKEllsvLKDKKLLFFSLLAILQQMITFSTTFGF--TPLIAKQ-LGASSFQLGLLSIIYLLP 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  84 YCL-TQVVGGHLGDRIGGEKVILLSASAWGFITVTTPLLAHLGsghlaFVTFSRILTGLLQGVYFPALTSLLSQRVQESE 162
Cdd:cd17490   243 NALaSLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLT-----LLYLLQALNGFGTGILFPLLMSLSIEGVPAEQ 317

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1958763261 163 RS----FTYSTVGAGSQVGTLVTGGIGSVLldrcGWQSVFYFSGGLTLL 207
Cdd:cd17490   318 RStamgFFQAIYALGMFLGPVLVGIISEAF----GLQTGFFVIGVIALL 362
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 62-209 1.43e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 42.80  E-value: 1.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  62 MSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSasawGFITVTTPLLAHLGSGHLAFVTFSRILTGL 141
Cdd:cd06174   230 LLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLI----GLLLMALGLALLLLAPSLLLLLLLLLLLGF 305

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958763261 142 LQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRC-GWQSVFYFSGGLTLLWV 209
Cdd:cd06174   306 GLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATfGLTGAFLVLAVLLLLAA 374
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 53-210 1.86e-04

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 42.59  E-value: 1.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  53 VTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVG-GHLGDRIGGEKVILLSA--SAWGFItvttpLLAHLGSGHL 129
Cdd:cd17331   225 MFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLvGPLTKRFGERSLLKLSValLAIGYL-----LLAFVTTVWQ 299

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 130 AFVTFsrILTGLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFYFSGGL-TLLW 208
Cdd:cd17331   300 LLVLL--LPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAInGLLT 377


                  ..
gi 1958763261 209 VY 210
Cdd:cd17331   378 VY 379
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
86-278 4.36e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.43  E-value: 4.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  86 LTQVVGGHLGDRIGGEK-----VILLSASAWGFITVTTPLLAHLG-SGHLAFVTFSRILTGLLQGVYFPALTSLLSQRVQ 159
Cdd:COG2211    61 ITDPLIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTAPDLSpTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTP 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 160 ES-ERSFTYSTVGAGSQVGTLVTGGIGSVLLD------RCGWQSVFYFSGGLTLLwvyyvykylldekdLVLALGVLAQG 232
Cdd:COG2211   141 DYeERTRLSSWRFAFAGLGGLLASVLPPPLVAafggdaALGYRLTALIFAVLGLL--------------AFLLTFFGTKE 206

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958763261 233 LPVTRPSKVP----WRQLFRKASVWAVICSQLSSACSFFILLSWLPTFFK 278
Cdd:COG2211   207 RPVPEEEKVSlkesLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFK 256
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 67-207 7.41e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 40.62  E-value: 7.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  67 GWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAwgfITVTTPLLAHLGSGHLAFVTFSRILTGLLQGVY 146
Cdd:cd17477   219 GLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALL---GALAALLLPLVPGLPLALLVLLFLWGGAAGPLY 295

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958763261 147 FPALTsLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFYFSGGLTLL 207
Cdd:cd17477   296 TLALA-LAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALL 355
PTR2 COG3104
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
66-287 1.34e-03

Dipeptide/tripeptide permease [Amino acid transport and metabolism];


Pssm-ID: 442338 [Multi-domain]  Cd Length: 479  Bit Score: 40.18  E-value: 1.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  66 FGWNKKEAGIVLSSFF-WGYcLTQVVGGHLGDR-IGGEKVILLSAS--AWGFItvttpLLAHLGSGHLAFVTFSRIL--T 139
Cdd:COG3104    50 LGLSEADAAAIYGAYTaLVY-LTPLLGGWLADRlLGQRRAILLGGIlmALGHF-----LLALPGGVTLFYLGLALIAvgN 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 140 GLLQgvyfPALTSLLSQRVQESER------SFTYSTVGAGSQVGTLVTGGIGSVLldrcGWQSVFYFSG-GLTL-LWVYY 211
Cdd:COG3104   124 GLFK----PNISSLVGQLYDPGDPrrdagfTIFYMGINIGAFLAPLLCGYLGEKY----GWHYGFGAAAiGMLIgLIIFL 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 212 VYKYLLDEKdlvlalgvlaqGLPVTRPSKVPWRQLFRKASVWAVIC--------SQLSSACSFFILLSWLPTFFKETFPH 283
Cdd:COG3104   196 LGRKYLGDI-----------GLEPDNPLSKKERLIAVALGALLLVLvlagllsnANIANYLLYVIAIIAYFIFILRSKKL 264


                  ....
gi 1958763261 284 SKAQ 287
Cdd:COG3104   265 TKEE 268
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 89-207 1.45e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 39.84  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  89 VVGGHLGDRIGGEKVILLSasawGFITVTTPLLAHLGSGHLAFVTFSrILTGLLQGVYFPALTSLLSQRVQESeRSFTYS 168
Cdd:cd17324   252 PLAGRLADRGGRRALLIAL----LLLAAALLLLTLLGPSPLLLLVGL-VLWGLGFFAAHSALQTRVLRLAPEA-RGLASS 325

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1958763261 169 TVGAGSQVGTLVTGGIGSVLLDRCGWQSVFYFSGGLTLL 207
Cdd:cd17324   326 LYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLL 364
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 73-207 1.52e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.91  E-value: 1.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  73 AGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTTPLLAHLGSGHLAFVTFSRILTGLLQGVYFPALTS 152
Cdd:cd06173    36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQA 115

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958763261 153 LLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFYFSGGLTLL 207
Cdd:cd06173   116 LLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLL 170
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 41-214 1.71e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 39.48  E-value: 1.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  41 LLLGTCLLYCTRVTM-PVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLsasaWGFITVTTP 119
Cdd:cd17330   179 LLLVYFLIALAFAGLeSVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLR----LGLLLAIIG 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 120 LLAHLGSGHLAFVTFSRILTGLLQGVYFPALTSLLSQRVQESERSfTYSTVGAGSQVGTLVTGG-IGSVLLDRCGWQSVF 198
Cdd:cd17330   255 LLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQG-KAQGIIQSLQSLARIIGPlLAGPLYSFLGPGVPF 333

                         170
                  ....*....|....*.
gi 1958763261 199 YFSGGLTLLWVYYVYK 214
Cdd:cd17330   334 LLAAGLLLIALFLLSL 349
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 61-284 3.21e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 38.71  E-value: 3.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  61 AMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSasawgfitvttpLLAHLGSGHLAFVT--FSRIL 138
Cdd:cd17474    24 AIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPG------------LLLFGIGGLLCGLSdsFALLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 139 TG-LLQGVYFPALTS----LLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDrCGWQSVFYFSGGLTLLwVYYVY 213
Cdd:cd17474    92 AGrALQGIGAAGLGPlaltLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAALIPV-AFLAI 169

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958763261 214 KYLLDEkdlvlalgvlaQGLPVTRPSKVPWRQLFRKASVWAVICSQLSSACSFFIL---LSWLPTFFKETFPHS 284
Cdd:cd17474   170 LFLLPE-----------PKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYfafLTYLPFLLELLYGIS 232
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 69-200 4.84e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 38.07  E-value: 4.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  69 NKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAwGFITVTTPLLAhlGSGHLAFVTFsrILTGLLQGVYFP 148
Cdd:cd17333   233 SDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSG-ALLGLLILLLA--PTLVVGLVAT--ALLGLFMAALFP 307

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958763261 149 ALTSLLSQRVQESERSFTYSTVGAGSqVGTLVTGGIGSVLLDRCGWQSVFYF 200
Cdd:cd17333   308 TILSLGISNLPYAKGKGTSVLLAAGS-IGGAIIPFIMGFIAEAVGIQTAMLL 358
MFS_DtpA_like cd17346
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...
 66-229 4.84e-03

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340904 [Multi-domain]  Cd Length: 399  Bit Score: 38.33  E-value: 4.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  66 FGWNKKEAGIVLSSF-FWGYcLTQVVGGHLGDRI-GGEKVILLSAS--AWGFITVTTPLLAHLGS-GHLAFVTFSrilTG 140
Cdd:cd17346    35 DGFSEADAASIYGAYtALVY-LTPIIGGWLADKVlGARRTVFIGGIlmALGYLLLALSPFSVSMLyLGLALIIVG---NG 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 141 LLQgvyfPALTSLLSQ--RVQESERS--FT--YSTVGAGSQVGTLVTGGIGSVLldrcGWQSVFYFSGGLTL--LWVYYV 212
Cdd:cd17346   111 LFK----PNISSLVGKlyDENDPRRDsgFSifYMGINLGAFLAPLLCGTLGDNY----GYHYGFGLAAVGMLlgLLIFLL 182

                         170
                  ....*....|....*..
gi 1958763261 213 YKYLLDEKDLVLALGVL 229
Cdd:cd17346   183 GRKKLLERKKMLAIIIL 199
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 3-207 5.04e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 37.92  E-value: 5.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261   3 SQRSSLMQPIPEETRKTPSAAAEDKRWSRPECQLWtGMLLLGTCLLYCTRVTMPVctvaMSQDFGWNKKEAGIVLSSFFW 82
Cdd:cd17478   167 LRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLL-IIVFLRSWVLSSLTTFLPF----YLVQRGYSLVFAGLLLSLFLF 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  83 GYCLTQVVGGHLGDRIGGEKVILLSasawgfITVTTPLLAHLGSGHLAFVTFSRILTGLLQGVYFPALTsLLSQRVQESE 162
Cdd:cd17478   242 AGAIGTLIGGPLSDRFGRRRVIIAS------LLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTV-VLAQELLPGN 314

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958763261 163 RSFTYS-----TVGAGSqVGTLVTGGIGsvllDRCGWQSVFYFSGGLTLL 207
Cdd:cd17478   315 VGLASGlmmglSFGLGG-IGAPVLGALA----DAFGLESVLLILALLPLL 359
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 61-283 5.10e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 37.94  E-value: 5.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  61 AMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSAsawgFITVTTPLLAHLgSGHLAFVTFSRILTG 140
Cdd:cd17504    21 TIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVL----AIYTAGSLLAAF-APNLPVLIAGRALQG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261 141 LLQGVyFPALTSLLSQRVQESER----SFTYSTVGAGSQVGTLvtggIGSVLLDRCGWQSVFYFSGGLtllwvyyvykyl 216
Cdd:cd17504    96 IGGAV-FPLAFALVREEFPPERVpvaqGILSATFGIGAGIGLP----LGGWIVQHLGWRWIFWTAAPV------------ 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958763261 217 ldekdlVLALGVLAqglPVTRPSkvpwrqLFRKASVWAVICSQLSSACSFFILLSWLPTFFKETFPH 283
Cdd:cd17504   159 ------AVLLAALV---PLIDLR------LLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPT 210
PRK12382 PRK12382
putative transporter; Provisional
 65-207 6.05e-03

putative transporter; Provisional


Pssm-ID: 183487 [Multi-domain]  Cd Length: 392  Bit Score: 37.73  E-value: 6.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763261  65 DFGWNkkEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSA--SAWGFITV---TTPLLAHLGSGhlafvtfsriLT 139
Cdd:PRK12382  245 SKGWA--MAGFTLTAFGGAFVLMRVLFGWMPDRFGGVKVAIVSLlvETVGLLLLwlaPTAWVALAGAA----------LT 312

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958763261 140 GLLQGVYFPALTSLLSQRVQESERSFTYSTVGAGSQVGTLVTGGIGSVLLDRCGWQSVFYFSGGLTLL 207
Cdd:PRK12382  313 GAGCSLIFPALGVEVVKRVPSQVRGTALGGYAAFQDIAYGVSGPLAGMLATSFGYPSVFLAGAISAVL 380
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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