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Conserved domains on  [gi|1958762278|ref|XP_038961077|]
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cadherin-like protein 26 isoform X2 [Rattus norvegicus]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182011)

cadherin repeat domain-containing protein similar to Homo sapiens desmoglein-2, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; cadherins are are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  17158740|28268172|27782885|11736639
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 144-246 1.19e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.62  E-value: 1.19e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762278 144 EFSITVKESQAAGQPIFQLLTVDLDQEntPNSQVLYFLVSQTPllrESGFRIDLISGEVRLSGCLHYETAPRFTLIIRAS 223
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNE---DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|...
gi 1958762278 224 DCGEPSLSSTATIHISVEDSNNH 246
Cdd:cd11304    76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 393-474 1.43e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.29  E-value: 1.43e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762278 393 FNATDPDR-ADSQIRYELVR-DPENWVTVDEKSGEVTTKRQIDRESPhvngSFYTIVVHAIDNGLPPLTGTGTLMLFLYD 470
Cdd:cd11304    19 VSATDPDSgENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREEQ----SSYTLTVTATDGGGPPLSSTATVTITVLD 94


                  ....
gi 1958762278 471 VNDN 474
Cdd:cd11304    95 VNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 254-367 4.80e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.49  E-value: 4.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762278 254 HYTIQISEGQ-VERDVLYLPVHDGDSPftPAWRTQFNIWDGNEEGHFDIttDPETnqGLLSIIKPLDYETQVAHSLLIVV 332
Cdd:cd11304     1 SYEVSVPENApPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1958762278 333 ENQEQlfncqegqlQPLRkamASTTVSVQVLDTND 367
Cdd:cd11304    75 TDGGG---------PPLS---STATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 60-136 6.22e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 51.16  E-value: 6.22e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958762278  60 NVSLMYLIRGPGVDefpeiGLFSIeDRQSGKIYVHRPVDREMTPSFMVYFDAVDRSTGKVVDESLIfNIRIRDVNDH 136
Cdd:cd11304    29 NGEVTYSIVSGNED-----GLFSI-DPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATV-TITVLDVNDN 98
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 144-246 1.19e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.62  E-value: 1.19e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762278 144 EFSITVKESQAAGQPIFQLLTVDLDQEntPNSQVLYFLVSQTPllrESGFRIDLISGEVRLSGCLHYETAPRFTLIIRAS 223
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNE---DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|...
gi 1958762278 224 DCGEPSLSSTATIHISVEDSNNH 246
Cdd:cd11304    76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 393-474 1.43e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.29  E-value: 1.43e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762278 393 FNATDPDR-ADSQIRYELVR-DPENWVTVDEKSGEVTTKRQIDRESPhvngSFYTIVVHAIDNGLPPLTGTGTLMLFLYD 470
Cdd:cd11304    19 VSATDPDSgENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREEQ----SSYTLTVTATDGGGPPLSSTATVTITVLD 94


                  ....
gi 1958762278 471 VNDN 474
Cdd:cd11304    95 VNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 394-476 1.89e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.17  E-value: 1.89e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762278  394 NATDPDR-ADSQIRYELVR-DPENWVTVDEKSGEVTTKRQIDRESphvnGSFYTIVVHAIDNGLPPLTGTGTLMLFLYDV 471
Cdd:smart00112   1 SATDADSgENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREE----QPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 1958762278  472 NDNAP 476
Cdd:smart00112  77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 165-248 9.84e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.16  E-value: 9.84e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762278  165 VDLDQEntPNSQVLYFLVSQTPllrESGFRIDLISGEVRLSGCLHYETAPRFTLIIRASDCGEPSLSSTATIHISVEDSN 244
Cdd:smart00112   3 TDADSG--ENGKVTYSILSGND---DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 1958762278  245 NHMP 248
Cdd:smart00112  78 DNAP 81
Cadherin pfam00028
Cadherin domain;
145-241 1.49e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.41  E-value: 1.49e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762278 145 FSITVKESQAAGQPIFQLLTVDLDQenTPNSQVLYFLVSQTPllrESGFRIDLISGEVRLSGCLHYETAPRFTLIIRASD 224
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL--GPNGRIFYSILGGGP---GGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 1958762278 225 CGEPSLSSTATIHISVE 241
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
393-464 5.29e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.87  E-value: 5.29e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958762278 393 FNATDPDRAD-SQIRYELVRD-PENWVTVDEKSGEVTTKRQIDRESPhvngSFYTIVVHAIDNGLPPLTGTGTL 464
Cdd:pfam00028  18 VTATDPDLGPnGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRESI----GEYELTVEATDSGGPPLSSTATV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 254-367 4.80e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.49  E-value: 4.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762278 254 HYTIQISEGQ-VERDVLYLPVHDGDSPftPAWRTQFNIWDGNEEGHFDIttDPETnqGLLSIIKPLDYETQVAHSLLIVV 332
Cdd:cd11304     1 SYEVSVPENApPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1958762278 333 ENQEQlfncqegqlQPLRkamASTTVSVQVLDTND 367
Cdd:cd11304    75 TDGGG---------PPLS---STATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 273-369 8.75e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.52  E-value: 8.75e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762278  273 VHDGDSPftPAWRTQFNIWDGNEEGHFDIttDPETnqGLLSIIKPLDYETQVAHSLLIVVENQEQlfncqegqlQPLRka 352
Cdd:smart00112   2 ATDADSG--ENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDGGG---------PPLS-- 64

                           90
                   ....*....|....*..
gi 1958762278  353 mASTTVSVQVLDTNDPP 369
Cdd:smart00112  65 -STATVTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
255-363 2.50e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 2.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762278 255 YTIQISEGQ-VERDVLYLPVHDGDSPftPAWRTQFNIWDGNEEGHFDITTDPetnqGLLSIIKPLDYETQVAHSLLIVVE 333
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958762278 334 NQeqlfncqegQLQPLRkamASTTVSVQVL 363
Cdd:pfam00028  75 DS---------GGPPLS---STATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 60-136 6.22e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 51.16  E-value: 6.22e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958762278  60 NVSLMYLIRGPGVDefpeiGLFSIeDRQSGKIYVHRPVDREMTPSFMVYFDAVDRSTGKVVDESLIfNIRIRDVNDH 136
Cdd:cd11304    29 NGEVTYSIVSGNED-----GLFSI-DPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATV-TITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 60-138 1.57e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.27  E-value: 1.57e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958762278   60 NVSLMYLIRGPGVDefpeiGLFSIeDRQSGKIYVHRPVDREMTPSFMVYFDAVDRSTGKVVDESLIfNIRIRDVNDHAP 138
Cdd:smart00112  10 NGKVTYSILSGNDD-----GLFSI-DPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATV-TITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
60-116 4.82e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.59  E-value: 4.82e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958762278  60 NVSLMYLIRGPGVDefpeiGLFSIeDRQSGKIYVHRPVDREMTPSFMVYFDAVDRST 116
Cdd:pfam00028  28 NGRIFYSILGGGPG-----GNFRI-DPDTGDISTTKPLDRESIGEYELTVEATDSGG 78
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 144-246 1.19e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.62  E-value: 1.19e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762278 144 EFSITVKESQAAGQPIFQLLTVDLDQEntPNSQVLYFLVSQTPllrESGFRIDLISGEVRLSGCLHYETAPRFTLIIRAS 223
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNE---DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|...
gi 1958762278 224 DCGEPSLSSTATIHISVEDSNNH 246
Cdd:cd11304    76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 393-474 1.43e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.29  E-value: 1.43e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762278 393 FNATDPDR-ADSQIRYELVR-DPENWVTVDEKSGEVTTKRQIDRESPhvngSFYTIVVHAIDNGLPPLTGTGTLMLFLYD 470
Cdd:cd11304    19 VSATDPDSgENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREEQ----SSYTLTVTATDGGGPPLSSTATVTITVLD 94


                  ....
gi 1958762278 471 VNDN 474
Cdd:cd11304    95 VNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 394-476 1.89e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.17  E-value: 1.89e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762278  394 NATDPDR-ADSQIRYELVR-DPENWVTVDEKSGEVTTKRQIDRESphvnGSFYTIVVHAIDNGLPPLTGTGTLMLFLYDV 471
Cdd:smart00112   1 SATDADSgENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREE----QPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 1958762278  472 NDNAP 476
Cdd:smart00112  77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 165-248 9.84e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.16  E-value: 9.84e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762278  165 VDLDQEntPNSQVLYFLVSQTPllrESGFRIDLISGEVRLSGCLHYETAPRFTLIIRASDCGEPSLSSTATIHISVEDSN 244
Cdd:smart00112   3 TDADSG--ENGKVTYSILSGND---DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 1958762278  245 NHMP 248
Cdd:smart00112  78 DNAP 81
Cadherin pfam00028
Cadherin domain;
145-241 1.49e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.41  E-value: 1.49e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762278 145 FSITVKESQAAGQPIFQLLTVDLDQenTPNSQVLYFLVSQTPllrESGFRIDLISGEVRLSGCLHYETAPRFTLIIRASD 224
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL--GPNGRIFYSILGGGP---GGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 1958762278 225 CGEPSLSSTATIHISVE 241
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
393-464 5.29e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.87  E-value: 5.29e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958762278 393 FNATDPDRAD-SQIRYELVRD-PENWVTVDEKSGEVTTKRQIDRESPhvngSFYTIVVHAIDNGLPPLTGTGTL 464
Cdd:pfam00028  18 VTATDPDLGPnGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRESI----GEYELTVEATDSGGPPLSSTATV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 254-367 4.80e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.49  E-value: 4.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762278 254 HYTIQISEGQ-VERDVLYLPVHDGDSPftPAWRTQFNIWDGNEEGHFDIttDPETnqGLLSIIKPLDYETQVAHSLLIVV 332
Cdd:cd11304     1 SYEVSVPENApPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1958762278 333 ENQEQlfncqegqlQPLRkamASTTVSVQVLDTND 367
Cdd:cd11304    75 TDGGG---------PPLS---STATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 273-369 8.75e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.52  E-value: 8.75e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762278  273 VHDGDSPftPAWRTQFNIWDGNEEGHFDIttDPETnqGLLSIIKPLDYETQVAHSLLIVVENQEQlfncqegqlQPLRka 352
Cdd:smart00112   2 ATDADSG--ENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDGGG---------PPLS-- 64

                           90
                   ....*....|....*..
gi 1958762278  353 mASTTVSVQVLDTNDPP 369
Cdd:smart00112  65 -STATVTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
255-363 2.50e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 2.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958762278 255 YTIQISEGQ-VERDVLYLPVHDGDSPftPAWRTQFNIWDGNEEGHFDITTDPetnqGLLSIIKPLDYETQVAHSLLIVVE 333
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958762278 334 NQeqlfncqegQLQPLRkamASTTVSVQVL 363
Cdd:pfam00028  75 DS---------GGPPLS---STATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 60-136 6.22e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 51.16  E-value: 6.22e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958762278  60 NVSLMYLIRGPGVDefpeiGLFSIeDRQSGKIYVHRPVDREMTPSFMVYFDAVDRSTGKVVDESLIfNIRIRDVNDH 136
Cdd:cd11304    29 NGEVTYSIVSGNED-----GLFSI-DPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATV-TITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 60-138 1.57e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.27  E-value: 1.57e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958762278   60 NVSLMYLIRGPGVDefpeiGLFSIeDRQSGKIYVHRPVDREMTPSFMVYFDAVDRSTGKVVDESLIfNIRIRDVNDHAP 138
Cdd:smart00112  10 NGKVTYSILSGNDD-----GLFSI-DPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATV-TITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
60-116 4.82e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.59  E-value: 4.82e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958762278  60 NVSLMYLIRGPGVDefpeiGLFSIeDRQSGKIYVHRPVDREMTPSFMVYFDAVDRST 116
Cdd:pfam00028  28 NGRIFYSILGGGPG-----GNFRI-DPDTGDISTTKPLDRESIGEYELTVEATDSGG 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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