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Conserved domains on  [gi|1958762136|ref|XP_038961027|]
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zinc fingers and homeoboxes protein 3 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf_C2H2_ZHX pfam18387
Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX ...
 105-155 4.50e-22

Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX proteins such as ZHX1. ZHXs are multidomain proteins comprising two C2H2 zinc finger motifs and five homeodomains. Both homeodomains and zinc fingers are short protein modules involved in protein-DNA and/or protein-protein interactions; they are frequently associated with roles in transcriptional regulation. All members of the ZHX family are reported to be able to form both homo- and heterodimers via the region containing homeodomain 1. ZHX1 is a transcriptional repressor which is ubiquitously expressed. It interacts with nuclear factor Y subunit A (NFYA) and DNA methyl transferase 3B (DNMT3B) for its repression activity. Changes in expression profiles of rat ZHX1 ortholog have been associated with glomerular disease. In addition to the five homeodomains, ZHX1, which also contains of two N terminal C2H2 zincfingers forms homodimers via homeodomain and can also form heterodimers with ZHX3.


:

Pssm-ID: 465737  Cd Length: 53  Bit Score: 90.08  E-value: 4.50e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958762136 105 KDPHFVCTGCSFLAKTPEGLSLHNAKCHSGEASFLWNVTKPDNHVVVEQSV 155
Cdd:pfam18387   1 ADPSFVCVECGFLAKKFEGLALHNAESHPGETNFTLQVVKRDNQTTVEQSL 51
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 493-546 4.10e-12

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 61.88  E-value: 4.10e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958762136 493 KKSHEQLSALKGSFCRNQFPGQSEVEHLTKVTGLSTREVRKWFSDRRYHCRNLK 546
Cdd:cd00086     6 RFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 614-659 9.74e-11

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


:

Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 58.03  E-value: 9.74e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1958762136  614 PEQLRVLESSFAQNPLPPEEELDRLRSETKMTRREIDGWFSERRKR 659
Cdd:smart00389  10 PEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAK 55
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 307-357 1.82e-08

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 51.48  E-value: 1.82e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958762136 307 MDSNSFLKNSFHKFPYPTKAELCYLTVVTKYPEEQLKIWFTAQRLKQGISW 357
Cdd:cd00086     9 PEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 761-818 4.54e-08

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 50.32  E-value: 4.54e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958762136 761 RVSYKKTAQQRHLLRQLFVQTQWPSNQDYDSIMAQTGLPRPEVVRWFGDSRYALKNGQ 818
Cdd:cd00086     2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
Homez super family cl13082
Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and ...
 845-881 1.27e-06

Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and an acidic domain and belongs to the superfamily of homeobox-containing proteins. The presence of leucine zippers suggests that Homez can function as a homo or heterodimer in the nucleus. It is thought that the first leucine zipper and homeodomain 1 (HD1)of Homez is responsible for dimerization and HD2 has a specific DNA-binding activity. Homez is also thought to function as a transcriptional repressor due to the acidic region in its C-terminal domain. Homez is involved in a complex regulatory network.


The actual alignment was detected with superfamily member pfam11569:

Pssm-ID: 463297  Cd Length: 57  Bit Score: 46.53  E-value: 1.27e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1958762136 845 LQDYYMTHKMLCEEDLQTLCEKTQMSAQQVKQWFAEK 881
Cdd:pfam11569  14 LEKYWAATGQLQEKDLDKLCQKSKMSYQQVRDWFASR 50
 
Name Accession Description Interval E-value
zf_C2H2_ZHX pfam18387
Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX ...
 105-155 4.50e-22

Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX proteins such as ZHX1. ZHXs are multidomain proteins comprising two C2H2 zinc finger motifs and five homeodomains. Both homeodomains and zinc fingers are short protein modules involved in protein-DNA and/or protein-protein interactions; they are frequently associated with roles in transcriptional regulation. All members of the ZHX family are reported to be able to form both homo- and heterodimers via the region containing homeodomain 1. ZHX1 is a transcriptional repressor which is ubiquitously expressed. It interacts with nuclear factor Y subunit A (NFYA) and DNA methyl transferase 3B (DNMT3B) for its repression activity. Changes in expression profiles of rat ZHX1 ortholog have been associated with glomerular disease. In addition to the five homeodomains, ZHX1, which also contains of two N terminal C2H2 zincfingers forms homodimers via homeodomain and can also form heterodimers with ZHX3.


Pssm-ID: 465737  Cd Length: 53  Bit Score: 90.08  E-value: 4.50e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958762136 105 KDPHFVCTGCSFLAKTPEGLSLHNAKCHSGEASFLWNVTKPDNHVVVEQSV 155
Cdd:pfam18387   1 ADPSFVCVECGFLAKKFEGLALHNAESHPGETNFTLQVVKRDNQTTVEQSL 51
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 493-546 4.10e-12

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 61.88  E-value: 4.10e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958762136 493 KKSHEQLSALKGSFCRNQFPGQSEVEHLTKVTGLSTREVRKWFSDRRYHCRNLK 546
Cdd:cd00086     6 RFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 490-543 1.23e-11

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 60.34  E-value: 1.23e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958762136  490 YKNKKSHEQLSALKGSFCRNQFPGQSEVEHLTKVTGLSTREVRKWFSDRRYHCR 543
Cdd:smart00389   4 KRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 614-659 9.74e-11

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 58.03  E-value: 9.74e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1958762136  614 PEQLRVLESSFAQNPLPPEEELDRLRSETKMTRREIDGWFSERRKR 659
Cdd:smart00389  10 PEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAK 55
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 614-659 2.00e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 57.25  E-value: 2.00e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958762136 614 PEQLRVLESSFAQNPLPPEEELDRLRSETKMTRREIDGWFSERRKR 659
Cdd:cd00086     9 PEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAK 54
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 307-357 1.82e-08

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 51.48  E-value: 1.82e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958762136 307 MDSNSFLKNSFHKFPYPTKAELCYLTVVTKYPEEQLKIWFTAQRLKQGISW 357
Cdd:cd00086     9 PEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 311-353 3.39e-08

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 50.71  E-value: 3.39e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1958762136  311 SFLKNSFHKFPYPTKAELCYLTVVTKYPEEQLKIWFTAQRLKQ 353
Cdd:smart00389  14 EELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 761-818 4.54e-08

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 50.32  E-value: 4.54e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958762136 761 RVSYKKTAQQRHLLRQLFVQTQWPSNQDYDSIMAQTGLPRPEVVRWFGDSRYALKNGQ 818
Cdd:cd00086     2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
Homeodomain pfam00046
Homeodomain;
495-539 5.10e-07

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 47.49  E-value: 5.10e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958762136 495 SHEQLSALKGSFCRNQFPGQSEVEHLTKVTGLSTREVRKWFSDRR 539
Cdd:pfam00046   8 TPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRR 52
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 757-815 6.47e-07

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 47.24  E-value: 6.47e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958762136  757 QPPSRVSYkkTAQQRHLLRQLFVQTQWPSNQDYDSIMAQTGLPRPEVVRWFGDSRYALK 815
Cdd:smart00389   1 KRRKRTSF--TPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
Homeodomain pfam00046
Homeodomain;
614-657 1.17e-06

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 46.34  E-value: 1.17e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958762136 614 PEQLRVLESSFAQNPLPPEEELDRLRSETKMTRREIDGWFSERR 657
Cdd:pfam00046   9 PEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRR 52
Homez pfam11569
Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and ...
 845-881 1.27e-06

Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and an acidic domain and belongs to the superfamily of homeobox-containing proteins. The presence of leucine zippers suggests that Homez can function as a homo or heterodimer in the nucleus. It is thought that the first leucine zipper and homeodomain 1 (HD1)of Homez is responsible for dimerization and HD2 has a specific DNA-binding activity. Homez is also thought to function as a transcriptional repressor due to the acidic region in its C-terminal domain. Homez is involved in a complex regulatory network.


Pssm-ID: 463297  Cd Length: 57  Bit Score: 46.53  E-value: 1.27e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1958762136 845 LQDYYMTHKMLCEEDLQTLCEKTQMSAQQVKQWFAEK 881
Cdd:pfam11569  14 LEKYWAATGQLQEKDLDKLCQKSKMSYQQVRDWFASR 50
Homeodomain pfam00046
Homeodomain;
313-353 6.06e-04

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 38.64  E-value: 6.06e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1958762136 313 LKNSFHKFPYPTKAELCYLTVVTKYPEEQLKIWFTAQRLKQ 353
Cdd:pfam00046  15 LEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKW 55
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 826-878 1.07e-03

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 38.00  E-value: 1.07e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1958762136  826 KRGNFPPGLLviapgnrELLQDYYMTHKMLCEEDLQTLCEKTQMSAQQVKQWF 878
Cdd:smart00389   4 KRTSFTPEQL-------EELEKEFQKNPYPSREEREELAKKLGLSERQVKVWF 49
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 842-878 1.74e-03

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 37.61  E-value: 1.74e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1958762136 842 RELLQDYYMTHKMLCEEDLQTLCEKTQMSAQQVKQWF 878
Cdd:cd00086    12 LEELEKEFEKNPYPSREEREELAKELGLTERQVKIWF 48
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
615-659 3.36e-03

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 39.34  E-value: 3.36e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958762136 615 EQLRVLESSFAQNPLPPEEELDRLRSETKMTRREIDGWFSERRKR 659
Cdd:COG5576    61 EQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAK 105
 
Name Accession Description Interval E-value
zf_C2H2_ZHX pfam18387
Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX ...
 105-155 4.50e-22

Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX proteins such as ZHX1. ZHXs are multidomain proteins comprising two C2H2 zinc finger motifs and five homeodomains. Both homeodomains and zinc fingers are short protein modules involved in protein-DNA and/or protein-protein interactions; they are frequently associated with roles in transcriptional regulation. All members of the ZHX family are reported to be able to form both homo- and heterodimers via the region containing homeodomain 1. ZHX1 is a transcriptional repressor which is ubiquitously expressed. It interacts with nuclear factor Y subunit A (NFYA) and DNA methyl transferase 3B (DNMT3B) for its repression activity. Changes in expression profiles of rat ZHX1 ortholog have been associated with glomerular disease. In addition to the five homeodomains, ZHX1, which also contains of two N terminal C2H2 zincfingers forms homodimers via homeodomain and can also form heterodimers with ZHX3.


Pssm-ID: 465737  Cd Length: 53  Bit Score: 90.08  E-value: 4.50e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958762136 105 KDPHFVCTGCSFLAKTPEGLSLHNAKCHSGEASFLWNVTKPDNHVVVEQSV 155
Cdd:pfam18387   1 ADPSFVCVECGFLAKKFEGLALHNAESHPGETNFTLQVVKRDNQTTVEQSL 51
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 493-546 4.10e-12

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 61.88  E-value: 4.10e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958762136 493 KKSHEQLSALKGSFCRNQFPGQSEVEHLTKVTGLSTREVRKWFSDRRYHCRNLK 546
Cdd:cd00086     6 RFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 490-543 1.23e-11

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 60.34  E-value: 1.23e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958762136  490 YKNKKSHEQLSALKGSFCRNQFPGQSEVEHLTKVTGLSTREVRKWFSDRRYHCR 543
Cdd:smart00389   4 KRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 614-659 9.74e-11

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 58.03  E-value: 9.74e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1958762136  614 PEQLRVLESSFAQNPLPPEEELDRLRSETKMTRREIDGWFSERRKR 659
Cdd:smart00389  10 PEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAK 55
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 614-659 2.00e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 57.25  E-value: 2.00e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958762136 614 PEQLRVLESSFAQNPLPPEEELDRLRSETKMTRREIDGWFSERRKR 659
Cdd:cd00086     9 PEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAK 54
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 307-357 1.82e-08

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 51.48  E-value: 1.82e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958762136 307 MDSNSFLKNSFHKFPYPTKAELCYLTVVTKYPEEQLKIWFTAQRLKQGISW 357
Cdd:cd00086     9 PEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 311-353 3.39e-08

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 50.71  E-value: 3.39e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1958762136  311 SFLKNSFHKFPYPTKAELCYLTVVTKYPEEQLKIWFTAQRLKQ 353
Cdd:smart00389  14 EELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 761-818 4.54e-08

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 50.32  E-value: 4.54e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958762136 761 RVSYKKTAQQRHLLRQLFVQTQWPSNQDYDSIMAQTGLPRPEVVRWFGDSRYALKNGQ 818
Cdd:cd00086     2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
Homeodomain pfam00046
Homeodomain;
495-539 5.10e-07

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 47.49  E-value: 5.10e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958762136 495 SHEQLSALKGSFCRNQFPGQSEVEHLTKVTGLSTREVRKWFSDRR 539
Cdd:pfam00046   8 TPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRR 52
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 757-815 6.47e-07

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 47.24  E-value: 6.47e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958762136  757 QPPSRVSYkkTAQQRHLLRQLFVQTQWPSNQDYDSIMAQTGLPRPEVVRWFGDSRYALK 815
Cdd:smart00389   1 KRRKRTSF--TPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
Homeodomain pfam00046
Homeodomain;
614-657 1.17e-06

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 46.34  E-value: 1.17e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958762136 614 PEQLRVLESSFAQNPLPPEEELDRLRSETKMTRREIDGWFSERR 657
Cdd:pfam00046   9 PEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRR 52
Homez pfam11569
Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and ...
 845-881 1.27e-06

Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and an acidic domain and belongs to the superfamily of homeobox-containing proteins. The presence of leucine zippers suggests that Homez can function as a homo or heterodimer in the nucleus. It is thought that the first leucine zipper and homeodomain 1 (HD1)of Homez is responsible for dimerization and HD2 has a specific DNA-binding activity. Homez is also thought to function as a transcriptional repressor due to the acidic region in its C-terminal domain. Homez is involved in a complex regulatory network.


Pssm-ID: 463297  Cd Length: 57  Bit Score: 46.53  E-value: 1.27e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1958762136 845 LQDYYMTHKMLCEEDLQTLCEKTQMSAQQVKQWFAEK 881
Cdd:pfam11569  14 LEKYWAATGQLQEKDLDKLCQKSKMSYQQVRDWFASR 50
Homeodomain pfam00046
Homeodomain;
313-353 6.06e-04

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 38.64  E-value: 6.06e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1958762136 313 LKNSFHKFPYPTKAELCYLTVVTKYPEEQLKIWFTAQRLKQ 353
Cdd:pfam00046  15 LEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKW 55
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 826-878 1.07e-03

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 38.00  E-value: 1.07e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1958762136  826 KRGNFPPGLLviapgnrELLQDYYMTHKMLCEEDLQTLCEKTQMSAQQVKQWF 878
Cdd:smart00389   4 KRTSFTPEQL-------EELEKEFQKNPYPSREEREELAKKLGLSERQVKVWF 49
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 627-659 1.45e-03

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 37.11  E-value: 1.45e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1958762136 627 NPLPPEEELDRLRSETKMTRREIDGWFSERRKR 659
Cdd:pfam05920   7 NPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 842-878 1.74e-03

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 37.61  E-value: 1.74e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1958762136 842 RELLQDYYMTHKMLCEEDLQTLCEKTQMSAQQVKQWF 878
Cdd:cd00086    12 LEELEKEFEKNPYPSREEREELAKELGLTERQVKIWF 48
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
615-659 3.36e-03

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 39.34  E-value: 3.36e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958762136 615 EQLRVLESSFAQNPLPPEEELDRLRSETKMTRREIDGWFSERRKR 659
Cdd:COG5576    61 EQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAK 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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