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Conserved domains on  [gi|1958761971|ref|XP_038960966|]
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protein sel-1 homolog 2 isoform X10 [Rattus norvegicus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11434433)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
2-284 1.28e-36

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 132.36  E-value: 1.28e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761971   2 AFIGKMYLEGNAAAPQNNATAFKYFSMAASKGNAIGLHGLGLLYFHGKGVPVNYGEALKYFQKAAEKGWPNAQFHLGFMY 81
Cdd:COG0790    30 AAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEKAAEQGDAEAQYNLGLMY 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761971  82 YSGSGVWKDYKLAFKYFYLASQSGQPLAIYYLAEMYATGTGVLRSCRTAVELYKgvcelghwaekfltayfaykdgdvds 161
Cdd:COG0790   110 EEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYR-------------------------- 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761971 162 sliqyallaemgyevaqsnsafileskkakilgkekmypmalllwnRAAIQGNAFARVKIGDYHYYGYGTKKDYETAATH 241
Cdd:COG0790   164 ----------------------------------------------KAAEQGDADAQYNLGVLYENGRGVPKDPAKALEW 197

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1958761971 242 YSIAADKHHsAQAMFNLAYMYEHGLGIAQDIHLARRLYDMAAQ 284
Cdd:COG0790   198 YRKAAEQGD-ADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAE 239
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
2-284 1.28e-36

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 132.36  E-value: 1.28e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761971   2 AFIGKMYLEGNAAAPQNNATAFKYFSMAASKGNAIGLHGLGLLYFHGKGVPVNYGEALKYFQKAAEKGWPNAQFHLGFMY 81
Cdd:COG0790    30 AAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEKAAEQGDAEAQYNLGLMY 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761971  82 YSGSGVWKDYKLAFKYFYLASQSGQPLAIYYLAEMYATGTGVLRSCRTAVELYKgvcelghwaekfltayfaykdgdvds 161
Cdd:COG0790   110 EEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYR-------------------------- 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761971 162 sliqyallaemgyevaqsnsafileskkakilgkekmypmalllwnRAAIQGNAFARVKIGDYHYYGYGTKKDYETAATH 241
Cdd:COG0790   164 ----------------------------------------------KAAEQGDADAQYNLGVLYENGRGVPKDPAKALEW 197

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1958761971 242 YSIAADKHHsAQAMFNLAYMYEHGLGIAQDIHLARRLYDMAAQ 284
Cdd:COG0790   198 YRKAAEQGD-ADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAE 239
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 71-105 2.55e-06

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 43.70  E-value: 2.55e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958761971   71 PNAQFHLGFMYYSGSGVWKDYKLAFKYFYLASQSG 105
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 35-69 7.12e-06

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 42.12  E-value: 7.12e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1958761971  35 AIGLHGLGLLYFHGKGVPVNYGEALKYFQKAAEKG 69
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
2-284 1.28e-36

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 132.36  E-value: 1.28e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761971   2 AFIGKMYLEGNAAAPQNNATAFKYFSMAASKGNAIGLHGLGLLYFHGKGVPVNYGEALKYFQKAAEKGWPNAQFHLGFMY 81
Cdd:COG0790    30 AAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEKAAEQGDAEAQYNLGLMY 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761971  82 YSGSGVWKDYKLAFKYFYLASQSGQPLAIYYLAEMYATGTGVLRSCRTAVELYKgvcelghwaekfltayfaykdgdvds 161
Cdd:COG0790   110 EEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYR-------------------------- 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761971 162 sliqyallaemgyevaqsnsafileskkakilgkekmypmalllwnRAAIQGNAFARVKIGDYHYYGYGTKKDYETAATH 241
Cdd:COG0790   164 ----------------------------------------------KAAEQGDADAQYNLGVLYENGRGVPKDPAKALEW 197

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1958761971 242 YSIAADKHHsAQAMFNLAYMYEHGLGIAQDIHLARRLYDMAAQ 284
Cdd:COG0790   198 YRKAAEQGD-ADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAE 239
TPR COG0790
TPR repeat [General function prediction only];
1-142 1.75e-34

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 126.97  E-value: 1.75e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761971   1 MAFIGKMYLEGNAAaPQNNATAFKYFSMAASKGNAIGLHGLGLLYFHGKGVPVNYGEALKYFQKAAEKGWPNAQFHLGFM 80
Cdd:COG0790    66 QYNLGLMYAEGRGV-PKDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLL 144

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958761971  81 YYSGSGVWKDYKLAFKYFYLASQSGQPLAIYYLAEMYATGTGVLRSCRTAVELYKGVCELGH 142
Cdd:COG0790   145 YLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGD 206
TPR COG0790
TPR repeat [General function prediction only];
1-140 1.99e-33

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 123.89  E-value: 1.99e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761971   1 MAFIGKMYLEGNAAaPQNNATAFKYFSMAASKGNAIGLHGLGLLYFHGKGVPVNYGEALKYFQKAAEKGWPNAQFHLGFM 80
Cdd:COG0790   102 QYNLGLMYEEGLGV-PQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVL 180

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761971  81 YYSGSGVWKDYKLAFKYFYLASQSGQPLAIYYLAEMYATGTGVLRSCRTAVELYKGVCEL 140
Cdd:COG0790   181 YENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAEQ 240
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 71-105 2.55e-06

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 43.70  E-value: 2.55e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958761971   71 PNAQFHLGFMYYSGSGVWKDYKLAFKYFYLASQSG 105
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 252-284 3.32e-06

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 43.32  E-value: 3.32e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958761971  252 AQAMFNLAYMYEHGLGIAQDIHLARRLYDMAAQ 284
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAE 33
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 35-69 7.12e-06

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 42.12  E-value: 7.12e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1958761971  35 AIGLHGLGLLYFHGKGVPVNYGEALKYFQKAAEKG 69
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 252-284 8.58e-06

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 42.12  E-value: 8.58e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1958761971 252 AQAMFNLAYMYEHGLGIAQDIHLARRLYDMAAQ 284
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAE 33
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 35-69 1.71e-05

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 41.39  E-value: 1.71e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958761971   35 AIGLHGLGLLYFHGKGVPVNYGEALKYFQKAAEKG 69
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
TPR COG0790
TPR repeat [General function prediction only];
195-284 7.98e-05

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 43.38  E-value: 7.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761971 195 KEKMYPMALLLWNRAAIQGNAFARVKIGDYHYYGYGTKKDYETAATHYSIAADKHHSAQAMFNLAYMYEHGLGIAQDIHL 274
Cdd:COG0790     6 AAAAAAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEK 85

                          90
                  ....*....|
gi 1958761971 275 ARRLYDMAAQ 284
Cdd:COG0790    86 ALEWFEKAAE 95
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 107-142 1.99e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 38.31  E-value: 1.99e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958761971  107 PLAIYYLAEMYATGTGVLRSCRTAVELYKGVCELGH 142
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 71-105 6.99e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 36.73  E-value: 6.99e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1958761971  71 PNAQFHLGFMYYSGSGVWKDYKLAFKYFYLASQSG 105
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 215-250 1.73e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 35.61  E-value: 1.73e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958761971  215 AFARVKIGDYHYYGYGTKKDYETAATHYSIAADKHH 250
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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