NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958761807|ref|XP_038960905|]
View 

dual oxidase maturation factor 1 isoform X1 [Rattus norvegicus]

Protein Classification

DuoxA domain-containing protein( domain architecture ID 10562893)

DuoxA domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DuoxA pfam10204
Dual oxidase maturation factor; DuoxA (Dual oxidase maturation factor) is the essential ...
 117-330 2.01e-106

Dual oxidase maturation factor; DuoxA (Dual oxidase maturation factor) is the essential protein necessary for the final release of DUOX2 (an NADPH:O2 oxidoreductase flavoprotein) from the endoplasmic reticulum. Dual oxidases (DUOX1 and DUOX2) constitute the catalytic core of the hydrogen peroxide generator, which generates H2O2 at the apical membrane of thyroid follicular cells, essential for iodination of thyroglobulin by thyroid peroxidases. DuoxA carries five membrane-integral regions including a reverse signal-anchor with external N-terminus (type III) and two N-glycosylation sites. It is conserved from nematodes to humans.


:

Pssm-ID: 462995  Cd Length: 277  Bit Score: 314.14  E-value: 2.01e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761807 117 GSEWSVGHINTNTTYKAFSPKRVSVHVGLQIGLGGLNITLTGTPVQQLNETINYNEEFTWRLGKSYAEEYAKALEKGLPD 196
Cdd:pfam10204  64 GSEWEVGEVTTNTSYKAFSNEEINADIGLHIGLRGVNVTLKGTPVGQLNETIDYNERFSWRFAGDMNEEYRAALEKGLPY 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761807 197 PVLYLAEKFAPRSP-CGLYNQYRLAGHYASAMLWVAFLCWLLANVMLsMPVLVYGGHMLLATGLFQLLALFFFSMTTSLm 275
Cdd:pfam10204 144 PILYVAEYFTLDSEgCRWGRQYRLAGYYASATLWTAFACWLLSNLLL-MPVPRYGGYMMLLTGAFMLFSNLIFSSLLPP- 221

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958761807 276 sCPLRL--GTAVLYTHHGPAFWITLATGLLCILLGLVMAVAHRMQPHRLKALFNLSS 330
Cdd:pfam10204 222 -CPLVIpfGGASLTTHYGWSFWLVLATGLLCLLLGLIIVILDLLFPHKLSTFFEVDY 277
 
Name Accession Description Interval E-value
DuoxA pfam10204
Dual oxidase maturation factor; DuoxA (Dual oxidase maturation factor) is the essential ...
 117-330 2.01e-106

Dual oxidase maturation factor; DuoxA (Dual oxidase maturation factor) is the essential protein necessary for the final release of DUOX2 (an NADPH:O2 oxidoreductase flavoprotein) from the endoplasmic reticulum. Dual oxidases (DUOX1 and DUOX2) constitute the catalytic core of the hydrogen peroxide generator, which generates H2O2 at the apical membrane of thyroid follicular cells, essential for iodination of thyroglobulin by thyroid peroxidases. DuoxA carries five membrane-integral regions including a reverse signal-anchor with external N-terminus (type III) and two N-glycosylation sites. It is conserved from nematodes to humans.


Pssm-ID: 462995  Cd Length: 277  Bit Score: 314.14  E-value: 2.01e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761807 117 GSEWSVGHINTNTTYKAFSPKRVSVHVGLQIGLGGLNITLTGTPVQQLNETINYNEEFTWRLGKSYAEEYAKALEKGLPD 196
Cdd:pfam10204  64 GSEWEVGEVTTNTSYKAFSNEEINADIGLHIGLRGVNVTLKGTPVGQLNETIDYNERFSWRFAGDMNEEYRAALEKGLPY 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761807 197 PVLYLAEKFAPRSP-CGLYNQYRLAGHYASAMLWVAFLCWLLANVMLsMPVLVYGGHMLLATGLFQLLALFFFSMTTSLm 275
Cdd:pfam10204 144 PILYVAEYFTLDSEgCRWGRQYRLAGYYASATLWTAFACWLLSNLLL-MPVPRYGGYMMLLTGAFMLFSNLIFSSLLPP- 221

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958761807 276 sCPLRL--GTAVLYTHHGPAFWITLATGLLCILLGLVMAVAHRMQPHRLKALFNLSS 330
Cdd:pfam10204 222 -CPLVIpfGGASLTTHYGWSFWLVLATGLLCLLLGLIIVILDLLFPHKLSTFFEVDY 277
 
Name Accession Description Interval E-value
DuoxA pfam10204
Dual oxidase maturation factor; DuoxA (Dual oxidase maturation factor) is the essential ...
 117-330 2.01e-106

Dual oxidase maturation factor; DuoxA (Dual oxidase maturation factor) is the essential protein necessary for the final release of DUOX2 (an NADPH:O2 oxidoreductase flavoprotein) from the endoplasmic reticulum. Dual oxidases (DUOX1 and DUOX2) constitute the catalytic core of the hydrogen peroxide generator, which generates H2O2 at the apical membrane of thyroid follicular cells, essential for iodination of thyroglobulin by thyroid peroxidases. DuoxA carries five membrane-integral regions including a reverse signal-anchor with external N-terminus (type III) and two N-glycosylation sites. It is conserved from nematodes to humans.


Pssm-ID: 462995  Cd Length: 277  Bit Score: 314.14  E-value: 2.01e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761807 117 GSEWSVGHINTNTTYKAFSPKRVSVHVGLQIGLGGLNITLTGTPVQQLNETINYNEEFTWRLGKSYAEEYAKALEKGLPD 196
Cdd:pfam10204  64 GSEWEVGEVTTNTSYKAFSNEEINADIGLHIGLRGVNVTLKGTPVGQLNETIDYNERFSWRFAGDMNEEYRAALEKGLPY 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761807 197 PVLYLAEKFAPRSP-CGLYNQYRLAGHYASAMLWVAFLCWLLANVMLsMPVLVYGGHMLLATGLFQLLALFFFSMTTSLm 275
Cdd:pfam10204 144 PILYVAEYFTLDSEgCRWGRQYRLAGYYASATLWTAFACWLLSNLLL-MPVPRYGGYMMLLTGAFMLFSNLIFSSLLPP- 221

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958761807 276 sCPLRL--GTAVLYTHHGPAFWITLATGLLCILLGLVMAVAHRMQPHRLKALFNLSS 330
Cdd:pfam10204 222 -CPLVIpfGGASLTTHYGWSFWLVLATGLLCLLLGLIIVILDLLFPHKLSTFFEVDY 277
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH