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Conserved domains on  [gi|1958753468|ref|XP_038959353|]
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EGF-like repeat and discoidin I-like domain-containing protein 3 isoform X4 [Rattus norvegicus]

Protein Classification

calcium-binding EGF-like domain-containing protein; discoidin domain-containing receptor( domain architecture ID 10041971)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions| discoidin domain-containing receptor (DDR) is a tyrosine-protein kinase that catalyzes the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 73-226 4.48e-63

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


:

Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 198.73  E-value: 4.48e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958753468  73 GPLGIEGGIiSNQQITASSTHRAlfglqKWYPYYARLNKkglINAWTAAENDRWPWIQINLQRKMRVTGVITQGAKRIGS 152
Cdd:cd00057     1 EPLGMESGL-ADDQITASSSYSS-----GWEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGGS 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958753468 153 PEYIKSYKIAYSNDGKTWAMYKVKGtnEEMVFRGNVDNNTPYANSFTPPIKAQYVRLYPQICRRHCTLRMELFG 226
Cdd:cd00057    72 SEWVTSYKVQYSLDGETWTTYKDKG--EEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 234-388 2.35e-53

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


:

Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 173.69  E-value: 2.35e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958753468 234 EPLGMKSGHiQDYQITASSIFRTlnmdmfTWEPRKARLDKqgkVNAWTSGHNDQSQWLQVDLLVPTKVTGIITQGAKDFG 313
Cdd:cd00057     1 EPLGMESGL-ADDQITASSSYSS------GWEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGG 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958753468 314 HVQFVGSYKLAYSNDGEHWTVYQDakQRKDKVFQGNFDNDTHRKNVIDPPIYARHIRILPWSWYGRITLRSELLG 388
Cdd:cd00057    71 SSEWVTSYKVQYSLDGETWTTYKD--KGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 32-68 6.97e-12

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 59.57  E-value: 6.97e-12
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958753468  32 DINECE-AEPCRNGGICTDLVANYSCECPGEFMGRNCQ 68
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 73-226 4.48e-63

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 198.73  E-value: 4.48e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958753468  73 GPLGIEGGIiSNQQITASSTHRAlfglqKWYPYYARLNKkglINAWTAAENDRWPWIQINLQRKMRVTGVITQGAKRIGS 152
Cdd:cd00057     1 EPLGMESGL-ADDQITASSSYSS-----GWEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGGS 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958753468 153 PEYIKSYKIAYSNDGKTWAMYKVKGtnEEMVFRGNVDNNTPYANSFTPPIKAQYVRLYPQICRRHCTLRMELFG 226
Cdd:cd00057    72 SEWVTSYKVQYSLDGETWTTYKDKG--EEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 234-388 2.35e-53

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 173.69  E-value: 2.35e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958753468 234 EPLGMKSGHiQDYQITASSIFRTlnmdmfTWEPRKARLDKqgkVNAWTSGHNDQSQWLQVDLLVPTKVTGIITQGAKDFG 313
Cdd:cd00057     1 EPLGMESGL-ADDQITASSSYSS------GWEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGG 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958753468 314 HVQFVGSYKLAYSNDGEHWTVYQDakQRKDKVFQGNFDNDTHRKNVIDPPIYARHIRILPWSWYGRITLRSELLG 388
Cdd:cd00057    71 SSEWVTSYKVQYSLDGETWTTYKD--KGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 70-227 5.25e-46

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 154.59  E-value: 5.25e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958753468   70 KCSGPLGIEggiiSNQQITASSthralfglQKWYPYYARLNKkGLINAWTAAENDRWPWIQINLQRKMRVTGVITQGakR 149
Cdd:smart00231   1 PCNEPLGLE----SDSQITASS--------SYWAAKIARLNG-GSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGR--R 65

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958753468  150 IGSPEYIKsYKIAYSNDGKTWAMYKVKgtnEEMVFRGNVDNNTPYANSFTPPIKAQYVRLYPQICRRHCTLRMELFGC 227
Cdd:smart00231  66 HGNGDWVT-YKLEYSDDGVNWTTYKDG---NSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 231-389 5.69e-39

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 136.10  E-value: 5.69e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958753468  231 GCSEPLGMKSghiqDYQITASSIFrtlnmdmftWEPRKARLDkQGKVNAWTSGHNDQSQWLQVDLLVPTKVTGIITQGAK 310
Cdd:smart00231   1 PCNEPLGLES----DSQITASSSY---------WAAKIARLN-GGSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRH 66

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958753468  311 DFGHVQfvgSYKLAYSNDGEHWTVYQDakqRKDKVFQGNFDNDTHRKNVIDPPIYARHIRILPWSWYGRITLRSELLGC 389
Cdd:smart00231  67 GNGDWV---TYKLEYSDDGVNWTTYKD---GNSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 247-386 4.78e-35

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 125.64  E-value: 4.78e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958753468 247 QITASSIFRTlnmdmfTWEPRkARLDkqGKVN-AWTSGHNDQSQWLQVDLLVPTKVTGIITQGAKDfGHVQFVGSYKLAY 325
Cdd:pfam00754   1 QITASSSYSG------EGPAA-AALD--GDPNtAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQD-GSNGYVTSYKIEY 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958753468 326 SNDGEHWTVYQDAKqrkdkvFQGNFDNDTHRKNVIDPPIYARHIRILPWSW--YGRITLRSEL 386
Cdd:pfam00754  71 SLDGENWTTVKDEK------IPGNNDNNTPVTNTFDPPIKARYVRIVPTSWngGNGIALRAEL 127
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 86-224 7.91e-31

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 114.47  E-value: 7.91e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958753468  86 QITASSTHRALfglqkwYPYYARLNKKgLINAWTAAENDRWPWIQINLQRKMRVTGVITQGAKRiGSPEYIKSYKIAYSN 165
Cdd:pfam00754   1 QITASSSYSGE------GPAAAALDGD-PNTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQD-GSNGYVTSYKIEYSL 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958753468 166 DGKTWAMYKVKGTNeemvfrGNVDNNTPYANSFTPPIKAQYVRLYPQ--ICRRHCTLRMEL 224
Cdd:pfam00754  73 DGENWTTVKDEKIP------GNNDNNTPVTNTFDPPIKARYVRIVPTswNGGNGIALRAEL 127
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 32-68 6.97e-12

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 59.57  E-value: 6.97e-12
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958753468  32 DINECE-AEPCRNGGICTDLVANYSCECPGEFMGRNCQ 68
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
32-68 1.22e-10

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 56.10  E-value: 1.22e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958753468   32 DINECEAE-PCRNGGICTDLVANYSCECPGEFM-GRNCQ 68
Cdd:smart00179   1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 36-59 5.80e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 5.80e-04
                          10        20
                  ....*....|....*....|....
gi 1958753468  36 CEAEPCRNGGICTDLVANYSCECP 59
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICP 24
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 73-226 4.48e-63

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 198.73  E-value: 4.48e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958753468  73 GPLGIEGGIiSNQQITASSTHRAlfglqKWYPYYARLNKkglINAWTAAENDRWPWIQINLQRKMRVTGVITQGAKRIGS 152
Cdd:cd00057     1 EPLGMESGL-ADDQITASSSYSS-----GWEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGGS 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958753468 153 PEYIKSYKIAYSNDGKTWAMYKVKGtnEEMVFRGNVDNNTPYANSFTPPIKAQYVRLYPQICRRHCTLRMELFG 226
Cdd:cd00057    72 SEWVTSYKVQYSLDGETWTTYKDKG--EEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 234-388 2.35e-53

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 173.69  E-value: 2.35e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958753468 234 EPLGMKSGHiQDYQITASSIFRTlnmdmfTWEPRKARLDKqgkVNAWTSGHNDQSQWLQVDLLVPTKVTGIITQGAKDFG 313
Cdd:cd00057     1 EPLGMESGL-ADDQITASSSYSS------GWEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGG 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958753468 314 HVQFVGSYKLAYSNDGEHWTVYQDakQRKDKVFQGNFDNDTHRKNVIDPPIYARHIRILPWSWYGRITLRSELLG 388
Cdd:cd00057    71 SSEWVTSYKVQYSLDGETWTTYKD--KGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 70-227 5.25e-46

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 154.59  E-value: 5.25e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958753468   70 KCSGPLGIEggiiSNQQITASSthralfglQKWYPYYARLNKkGLINAWTAAENDRWPWIQINLQRKMRVTGVITQGakR 149
Cdd:smart00231   1 PCNEPLGLE----SDSQITASS--------SYWAAKIARLNG-GSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGR--R 65

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958753468  150 IGSPEYIKsYKIAYSNDGKTWAMYKVKgtnEEMVFRGNVDNNTPYANSFTPPIKAQYVRLYPQICRRHCTLRMELFGC 227
Cdd:smart00231  66 HGNGDWVT-YKLEYSDDGVNWTTYKDG---NSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 231-389 5.69e-39

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 136.10  E-value: 5.69e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958753468  231 GCSEPLGMKSghiqDYQITASSIFrtlnmdmftWEPRKARLDkQGKVNAWTSGHNDQSQWLQVDLLVPTKVTGIITQGAK 310
Cdd:smart00231   1 PCNEPLGLES----DSQITASSSY---------WAAKIARLN-GGSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRH 66

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958753468  311 DFGHVQfvgSYKLAYSNDGEHWTVYQDakqRKDKVFQGNFDNDTHRKNVIDPPIYARHIRILPWSWYGRITLRSELLGC 389
Cdd:smart00231  67 GNGDWV---TYKLEYSDDGVNWTTYKD---GNSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 247-386 4.78e-35

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 125.64  E-value: 4.78e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958753468 247 QITASSIFRTlnmdmfTWEPRkARLDkqGKVN-AWTSGHNDQSQWLQVDLLVPTKVTGIITQGAKDfGHVQFVGSYKLAY 325
Cdd:pfam00754   1 QITASSSYSG------EGPAA-AALD--GDPNtAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQD-GSNGYVTSYKIEY 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958753468 326 SNDGEHWTVYQDAKqrkdkvFQGNFDNDTHRKNVIDPPIYARHIRILPWSW--YGRITLRSEL 386
Cdd:pfam00754  71 SLDGENWTTVKDEK------IPGNNDNNTPVTNTFDPPIKARYVRIVPTSWngGNGIALRAEL 127
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 86-224 7.91e-31

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 114.47  E-value: 7.91e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958753468  86 QITASSTHRALfglqkwYPYYARLNKKgLINAWTAAENDRWPWIQINLQRKMRVTGVITQGAKRiGSPEYIKSYKIAYSN 165
Cdd:pfam00754   1 QITASSSYSGE------GPAAAALDGD-PNTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQD-GSNGYVTSYKIEYSL 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958753468 166 DGKTWAMYKVKGTNeemvfrGNVDNNTPYANSFTPPIKAQYVRLYPQ--ICRRHCTLRMEL 224
Cdd:pfam00754  73 DGENWTTVKDEKIP------GNNDNNTPVTNTFDPPIKARYVRIVPTswNGGNGIALRAEL 127
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 32-68 6.97e-12

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 59.57  E-value: 6.97e-12
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958753468  32 DINECE-AEPCRNGGICTDLVANYSCECPGEFMGRNCQ 68
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
32-68 1.22e-10

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 56.10  E-value: 1.22e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958753468   32 DINECEAE-PCRNGGICTDLVANYSCECPGEFM-GRNCQ 68
Cdd:smart00179   1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 35-68 5.61e-06

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 42.85  E-value: 5.61e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1958753468  35 ECEAE-PCRNGGICTDLVANYSCECPGEFMG-RNCQ 68
Cdd:cd00053     1 ECAASnPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 36-59 5.80e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 5.80e-04
                          10        20
                  ....*....|....*....|....
gi 1958753468  36 CEAEPCRNGGICTDLVANYSCECP 59
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICP 24
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 41-59 1.30e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 35.77  E-value: 1.30e-03
                          10
                  ....*....|....*....
gi 1958753468  41 CRNGGICTDLVANYSCECP 59
Cdd:pfam12661   1 CQNGGTCVDGVNGYKCQCP 19
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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