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Conserved domains on  [gi|1958752805|ref|XP_038959101|]
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macrophage colony-stimulating factor 1 isoform X5 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CSF-1 super family cl05080
Macrophage colony stimulating factor-1 (CSF-1); Colony stimulating factor 1 (CSF-1) is a ...
 40-206 4.98e-83

Macrophage colony stimulating factor-1 (CSF-1); Colony stimulating factor 1 (CSF-1) is a homodimeric polypeptide growth factor whose primary function is to regulate the survival, proliferation, differentiation, and function of cells of the mononuclear phagocytic lineage. This lineage includes mononuclear phagocytic precursors, blood monocytes, tissue macrophages, osteoclasts, and microglia of the brain, all of which possess cell surface receptors for CSF-1. The protein has also been linked with male fertility and mutations in the Csf-1 gene have been found to cause osteopetrosis and failure of tooth eruption. Structurally these are short-chain 4-helical cytokines.


The actual alignment was detected with superfamily member pfam05337:

Pssm-ID: 398810  Cd Length: 140  Bit Score: 249.97  E-value: 4.98e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752805  40 HMIGNGHLQILQQLIDSQMETACLIEYKFVDQEQLDDPVCYLKKAFVLVQVIIEETMRFKDNTPNANATERLQELSMKLN 119
Cdd:pfam05337   1 HMIGNGHLKVLQQLIDSQMETSCQIAFEFVDQEQLDDPVCYLKKAFLLVQDIMEDTMRFKDNTPNANAIVQLQELSLRLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752805 120 SCFIKDYKEQNehsldrrhsvdpedilgtrnspshpysEACVQTYKESPLRLLEKIKNFFNETKNFLEKDWNIFSKNCND 199
Cdd:pfam05337  81 SCFTKDYEEQD---------------------------KACVRTFHETPLQLLEKIKNVFNETKNLLEKDWNIFSKNCNN 133


                  ....*..
gi 1958752805 200 SFAKCSS 206
Cdd:pfam05337 134 SFAKCSS 140
 
Name Accession Description Interval E-value
CSF-1 pfam05337
Macrophage colony stimulating factor-1 (CSF-1); Colony stimulating factor 1 (CSF-1) is a ...
 40-206 4.98e-83

Macrophage colony stimulating factor-1 (CSF-1); Colony stimulating factor 1 (CSF-1) is a homodimeric polypeptide growth factor whose primary function is to regulate the survival, proliferation, differentiation, and function of cells of the mononuclear phagocytic lineage. This lineage includes mononuclear phagocytic precursors, blood monocytes, tissue macrophages, osteoclasts, and microglia of the brain, all of which possess cell surface receptors for CSF-1. The protein has also been linked with male fertility and mutations in the Csf-1 gene have been found to cause osteopetrosis and failure of tooth eruption. Structurally these are short-chain 4-helical cytokines.


Pssm-ID: 398810  Cd Length: 140  Bit Score: 249.97  E-value: 4.98e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752805  40 HMIGNGHLQILQQLIDSQMETACLIEYKFVDQEQLDDPVCYLKKAFVLVQVIIEETMRFKDNTPNANATERLQELSMKLN 119
Cdd:pfam05337   1 HMIGNGHLKVLQQLIDSQMETSCQIAFEFVDQEQLDDPVCYLKKAFLLVQDIMEDTMRFKDNTPNANAIVQLQELSLRLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752805 120 SCFIKDYKEQNehsldrrhsvdpedilgtrnspshpysEACVQTYKESPLRLLEKIKNFFNETKNFLEKDWNIFSKNCND 199
Cdd:pfam05337  81 SCFTKDYEEQD---------------------------KACVRTFHETPLQLLEKIKNVFNETKNLLEKDWNIFSKNCNN 133


                  ....*..
gi 1958752805 200 SFAKCSS 206
Cdd:pfam05337 134 SFAKCSS 140
 
Name Accession Description Interval E-value
CSF-1 pfam05337
Macrophage colony stimulating factor-1 (CSF-1); Colony stimulating factor 1 (CSF-1) is a ...
 40-206 4.98e-83

Macrophage colony stimulating factor-1 (CSF-1); Colony stimulating factor 1 (CSF-1) is a homodimeric polypeptide growth factor whose primary function is to regulate the survival, proliferation, differentiation, and function of cells of the mononuclear phagocytic lineage. This lineage includes mononuclear phagocytic precursors, blood monocytes, tissue macrophages, osteoclasts, and microglia of the brain, all of which possess cell surface receptors for CSF-1. The protein has also been linked with male fertility and mutations in the Csf-1 gene have been found to cause osteopetrosis and failure of tooth eruption. Structurally these are short-chain 4-helical cytokines.


Pssm-ID: 398810  Cd Length: 140  Bit Score: 249.97  E-value: 4.98e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752805  40 HMIGNGHLQILQQLIDSQMETACLIEYKFVDQEQLDDPVCYLKKAFVLVQVIIEETMRFKDNTPNANATERLQELSMKLN 119
Cdd:pfam05337   1 HMIGNGHLKVLQQLIDSQMETSCQIAFEFVDQEQLDDPVCYLKKAFLLVQDIMEDTMRFKDNTPNANAIVQLQELSLRLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752805 120 SCFIKDYKEQNehsldrrhsvdpedilgtrnspshpysEACVQTYKESPLRLLEKIKNFFNETKNFLEKDWNIFSKNCND 199
Cdd:pfam05337  81 SCFTKDYEEQD---------------------------KACVRTFHETPLQLLEKIKNVFNETKNLLEKDWNIFSKNCNN 133


                  ....*..
gi 1958752805 200 SFAKCSS 206
Cdd:pfam05337 134 SFAKCSS 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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