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Conserved domains on  [gi|1958752789|ref|XP_038959098|]
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solute carrier family 25, member 54 isoform X2 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PTZ00169 super family cl36523
ADP/ATP transporter on adenylate translocase; Provisional
124-376 3.44e-28

ADP/ATP transporter on adenylate translocase; Provisional


The actual alignment was detected with superfamily member PTZ00169:

Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 112.17  E-value: 3.44e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752789 124 VAAGIASAITRTCTAPLDRLKVMIQVQSS----KMSKLR----LVHVFKQMVKEGGLFSLWRGNGVNIFKITPETAIKIG 195
Cdd:PTZ00169   12 LMGGISAAISKTAVAPIERVKMLIQTQDSipeiKSGKVPrysgIVNCFRRVSKEQGVLSLWRGNTANVIRYFPTQAFNFA 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752789 196 AYEQYKKLLSFEDANLGFLQRFTA----GSMAGITSQTCVYPLEVIKTRLI--LGRTG--EFSGIIDCGRKLLRREGIQA 267
Cdd:PTZ00169   92 FKDYFKNMFPKYNQKTDFWKFFGVnilsGGLAGASSLLIVYPLDFARTRLAsdIGKGGdrEFTGLFDCLMKISKQTGFLS 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752789 268 FSRGYVPNLLSIVPYAGLDLTIFELLKNYWLEHYAESSVNPGLAIVLGCSTLShtfgQLASFPLNLVRTRMQAAMLENET 347
Cdd:PTZ00169  172 LYQGFGVSVQGIIVYRGAYFGLYDSAKALLFGNDKNTNILYKWAVAQTVTILA----GLISYPFDTVRRRMMMMSGRKAK 247
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1958752789 348 IPMM-----QLIQEIYTKEGKKGFFRGLTPNVLK 376
Cdd:PTZ00169  248 SEIQytgtlDCWKKILKNEGLGGFFKGAWANVLR 281
EFh super family cl08302
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
31-74 1.79e-05

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


The actual alignment was detected with superfamily member cd00051:

Pssm-ID: 415501 [Multi-domain]  Cd Length: 63  Bit Score: 42.15  E-value: 1.79e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958752789  31 IDASEVVAAMKSLGIHISLAQANDILKSMDADGSMTVDWDEWRD 74
Cdd:cd00051    17 ISADELKAALKSLGEGLSEEEIDEMIREVDKDGDGKIDFEEFLE 60
 
Name Accession Description Interval E-value
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
124-376 3.44e-28

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 112.17  E-value: 3.44e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752789 124 VAAGIASAITRTCTAPLDRLKVMIQVQSS----KMSKLR----LVHVFKQMVKEGGLFSLWRGNGVNIFKITPETAIKIG 195
Cdd:PTZ00169   12 LMGGISAAISKTAVAPIERVKMLIQTQDSipeiKSGKVPrysgIVNCFRRVSKEQGVLSLWRGNTANVIRYFPTQAFNFA 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752789 196 AYEQYKKLLSFEDANLGFLQRFTA----GSMAGITSQTCVYPLEVIKTRLI--LGRTG--EFSGIIDCGRKLLRREGIQA 267
Cdd:PTZ00169   92 FKDYFKNMFPKYNQKTDFWKFFGVnilsGGLAGASSLLIVYPLDFARTRLAsdIGKGGdrEFTGLFDCLMKISKQTGFLS 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752789 268 FSRGYVPNLLSIVPYAGLDLTIFELLKNYWLEHYAESSVNPGLAIVLGCSTLShtfgQLASFPLNLVRTRMQAAMLENET 347
Cdd:PTZ00169  172 LYQGFGVSVQGIIVYRGAYFGLYDSAKALLFGNDKNTNILYKWAVAQTVTILA----GLISYPFDTVRRRMMMMSGRKAK 247
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1958752789 348 IPMM-----QLIQEIYTKEGKKGFFRGLTPNVLK 376
Cdd:PTZ00169  248 SEIQytgtlDCWKKILKNEGLGGFFKGAWANVLR 281
Mito_carr pfam00153
Mitochondrial carrier protein;
119-205 8.62e-26

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 99.65  E-value: 8.62e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752789 119 WWKRLVAAGIASAITRTCTAPLDRLKVMIQVQSSKMSKLR--LVHVFKQMVKEGGLFSLWRGNGVNIFKITPETAIKIGA 196
Cdd:pfam00153   5 FLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSKGrgILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAIYFGT 84

                  ....*....
gi 1958752789 197 YEQYKKLLS 205
Cdd:pfam00153  85 YETLKRLLL 93
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
31-74 1.79e-05

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 42.15  E-value: 1.79e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958752789  31 IDASEVVAAMKSLGIHISLAQANDILKSMDADGSMTVDWDEWRD 74
Cdd:cd00051    17 ISADELKAALKSLGEGLSEEEIDEMIREVDKDGDGKIDFEEFLE 60
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
31-82 6.41e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 39.78  E-value: 6.41e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958752789  31 IDASEVVAAMKSLGIhiSLAQANDILKSMDADGSMTVDWDEWRDYF--FFHPAK 82
Cdd:COG5126    86 ISADEFRRLLTALGV--SEEEADELFARLDTDGDGKISFEEFVAAVrdYYTPDA 137
 
Name Accession Description Interval E-value
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
124-376 3.44e-28

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 112.17  E-value: 3.44e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752789 124 VAAGIASAITRTCTAPLDRLKVMIQVQSS----KMSKLR----LVHVFKQMVKEGGLFSLWRGNGVNIFKITPETAIKIG 195
Cdd:PTZ00169   12 LMGGISAAISKTAVAPIERVKMLIQTQDSipeiKSGKVPrysgIVNCFRRVSKEQGVLSLWRGNTANVIRYFPTQAFNFA 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752789 196 AYEQYKKLLSFEDANLGFLQRFTA----GSMAGITSQTCVYPLEVIKTRLI--LGRTG--EFSGIIDCGRKLLRREGIQA 267
Cdd:PTZ00169   92 FKDYFKNMFPKYNQKTDFWKFFGVnilsGGLAGASSLLIVYPLDFARTRLAsdIGKGGdrEFTGLFDCLMKISKQTGFLS 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752789 268 FSRGYVPNLLSIVPYAGLDLTIFELLKNYWLEHYAESSVNPGLAIVLGCSTLShtfgQLASFPLNLVRTRMQAAMLENET 347
Cdd:PTZ00169  172 LYQGFGVSVQGIIVYRGAYFGLYDSAKALLFGNDKNTNILYKWAVAQTVTILA----GLISYPFDTVRRRMMMMSGRKAK 247
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1958752789 348 IPMM-----QLIQEIYTKEGKKGFFRGLTPNVLK 376
Cdd:PTZ00169  248 SEIQytgtlDCWKKILKNEGLGGFFKGAWANVLR 281
Mito_carr pfam00153
Mitochondrial carrier protein;
119-205 8.62e-26

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 99.65  E-value: 8.62e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752789 119 WWKRLVAAGIASAITRTCTAPLDRLKVMIQVQSSKMSKLR--LVHVFKQMVKEGGLFSLWRGNGVNIFKITPETAIKIGA 196
Cdd:pfam00153   5 FLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSKGrgILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAIYFGT 84

                  ....*....
gi 1958752789 197 YEQYKKLLS 205
Cdd:pfam00153  85 YETLKRLLL 93
Mito_carr pfam00153
Mitochondrial carrier protein;
211-301 8.82e-25

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 96.96  E-value: 8.82e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752789 211 LGFLQRFTAGSMAGITSQTCVYPLEVIKTRLILGRT---GEFSGIIDCGRKLLRREGIQAFSRGYVPNLLSIVPYAGLDL 287
Cdd:pfam00153   3 LSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGsgkSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAIYF 82
                          90
                  ....*....|....
gi 1958752789 288 TIFELLKNYWLEHY 301
Cdd:pfam00153  83 GTYETLKRLLLKKL 96
Mito_carr pfam00153
Mitochondrial carrier protein;
314-396 1.53e-12

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 63.06  E-value: 1.53e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752789 314 LGCSTLSHTFGQLASFPLNLVRTRMQA--AMLENETIPMMQLIQEIYTKEGKKGFFRGLTPNVLKLLPAVGIGCVAHELV 391
Cdd:pfam00153   9 LLAGGIAGAIAVTVTYPLDVVKTRLQVqgGSGKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAIYFGTYETL 88

                  ....*
gi 1958752789 392 NLLFG 396
Cdd:pfam00153  89 KRLLL 93
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
208-369 7.01e-06

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 47.46  E-value: 7.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752789 208 DANLGFLQRFTAGSMAGITSQTCVYPLEVIKTRL---------ILGRTGEFSGIIDCGRKLLRREGIQAFSRGYVPNLLS 278
Cdd:PTZ00169    2 DKKTNFATDFLMGGISAAISKTAVAPIERVKMLIqtqdsipeiKSGKVPRYSGIVNCFRRVSKEQGVLSLWRGNTANVIR 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752789 279 IVPYAGLDLTIFELLKNYWLEHYAESSVNPGLAIVLGCSTLSHTFGQLASFPLNLVRTRMQAAMLEN---ETIPMMQLIQ 355
Cdd:PTZ00169   82 YFPTQAFNFAFKDYFKNMFPKYNQKTDFWKFFGVNILSGGLAGASSLLIVYPLDFARTRLASDIGKGgdrEFTGLFDCLM 161
                         170
                  ....*....|....
gi 1958752789 356 EIYTKEGKKGFFRG 369
Cdd:PTZ00169  162 KISKQTGFLSLYQG 175
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
31-74 1.79e-05

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 42.15  E-value: 1.79e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958752789  31 IDASEVVAAMKSLGIHISLAQANDILKSMDADGSMTVDWDEWRD 74
Cdd:cd00051    17 ISADELKAALKSLGEGLSEEEIDEMIREVDKDGDGKIDFEEFLE 60
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
31-82 6.41e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 39.78  E-value: 6.41e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958752789  31 IDASEVVAAMKSLGIhiSLAQANDILKSMDADGSMTVDWDEWRDYF--FFHPAK 82
Cdd:COG5126    86 ISADEFRRLLTALGV--SEEEADELFARLDTDGDGKISFEEFVAAVrdYYTPDA 137
PTZ00168 PTZ00168
mitochondrial carrier protein; Provisional
214-362 4.13e-03

mitochondrial carrier protein; Provisional


Pssm-ID: 185494 [Multi-domain]  Cd Length: 259  Bit Score: 38.75  E-value: 4.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752789 214 LQRFTAGSMAGITSQTCVYPLEVIKTRLILGRTGEFSGIidcgRKLLrregiqafsRGYVPNLLSIVPYAGLDLTIFELL 293
Cdd:PTZ00168    4 FHNLVTGALSGVIVDAVLYPIDSIKTNIQAKKSFSFSDI----KKLY---------SGILPTLVGTVPASAFFYCFYELS 70
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958752789 294 KNYwLEHYAESSVNPGLAIVlgCSTLSHTFGQLASFPLNLVRTRMQAAmlenETIPMMQLIQEIYTKEG 362
Cdd:PTZ00168   71 KKL-LTEYRENISKTNLYLI--STSIAEITACIVRLPFEIVKQNMQVS----GNISVLKTIYEITQREG 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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