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Conserved domains on  [gi|1958749644|ref|XP_038957872|]
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WD repeat-containing protein 70 isoform X1 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-285 4.97e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 106.65  E-value: 4.97e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644  17 HQIKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMECIKG-------------DQYIV----------------DMANT- 66
Cdd:cd00200    10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGhtgpvrdvaasadGTYLAsgssdktirlwdletgECVRTl 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644  67 KGHTAMLHTGSWHPKikGEFM-TCSNDATVRLWEVENPKKQKsvfkprTMQGKKVIPTTCTYSRDGNLVAAACQNGSIQI 145
Cdd:cd00200    90 TGHTSYVSSVAFSPD--GRILsSSSRDKTIKVWDVETGKCLT------TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644 146 WD-------RNLTVHpkfhykqahapgTDT-SCVAFSYDGNVLASRGGDDTLKLWDVRQFN--KPLFSASDlptlfPMTD 215
Cdd:cd00200   162 WDlrtgkcvATLTGH------------TGEvNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKclGTLRGHEN-----GVNS 224

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644 216 CCFSPDDKLIVTGTsvqrgcGSGKLVFFERRTFQRVYEIHITDASVVRCLWHPKLNQIMVGTGNGLAKVY 285
Cdd:cd00200   225 VAFSPDGYLLASGS------EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-285 4.97e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 106.65  E-value: 4.97e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644  17 HQIKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMECIKG-------------DQYIV----------------DMANT- 66
Cdd:cd00200    10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGhtgpvrdvaasadGTYLAsgssdktirlwdletgECVRTl 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644  67 KGHTAMLHTGSWHPKikGEFM-TCSNDATVRLWEVENPKKQKsvfkprTMQGKKVIPTTCTYSRDGNLVAAACQNGSIQI 145
Cdd:cd00200    90 TGHTSYVSSVAFSPD--GRILsSSSRDKTIKVWDVETGKCLT------TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644 146 WD-------RNLTVHpkfhykqahapgTDT-SCVAFSYDGNVLASRGGDDTLKLWDVRQFN--KPLFSASDlptlfPMTD 215
Cdd:cd00200   162 WDlrtgkcvATLTGH------------TGEvNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKclGTLRGHEN-----GVNS 224

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644 216 CCFSPDDKLIVTGTsvqrgcGSGKLVFFERRTFQRVYEIHITDASVVRCLWHPKLNQIMVGTGNGLAKVY 285
Cdd:cd00200   225 VAFSPDGYLLASGS------EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
67-285 1.23e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.13  E-value: 1.23e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644  67 KGHTAMLHTGSWHPKikGEFM-TCSNDATVRLWEVENPKKqksvfkPRTMQGKKVIPTTCTYSRDGNLVAAACQNGSIQI 145
Cdd:COG2319   117 TGHTGAVRSVAFSPD--GKTLaSGSADGTVRLWDLATGKL------LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644 146 WD-------RNLTVHPKFHYkqahapgtdtsCVAFSYDGNVLASRGGDDTLKLWDVRQfNKPLFSASDLPtlFPMTDCCF 218
Cdd:COG2319   189 WDlatgkllRTLTGHTGAVR-----------SVAFSPDGKLLASGSADGTVRLWDLAT-GKLLRTLTGHS--GSVRSVAF 254

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958749644 219 SPDDKLIVTGTsvqrgcGSGKLVFFERRTFQRVYEIHITDASVVRCLWHPKLNQIMVGTGNGLAKVY 285
Cdd:COG2319   255 SPDGRLLASGS------ADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
PTZ00420 PTZ00420
coronin; Provisional
 67-205 1.37e-08

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 56.88  E-value: 1.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644  67 KGHTAMLHTGSWHPKikGEFMTCSN--DATVRLWEVENPKKQKSVFKPRTMQGKKvipttctYSRDGNLVAAACQNGSIQ 144
Cdd:PTZ00420  122 KGHKKKISIIDWNPM--NYYIMCSSgfDSFVNIWDIENEKRAFQINMPKKLSSLK-------WNIKGNLLSGTCVGKHMH 192

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958749644 145 IWD-RNLTVHPKFHykqAHAPGTDTSCV---AFSYDGNVLASRGGDDT----LKLWDVRQFNKPLFSAS 205
Cdd:PTZ00420  193 IIDpRKQEIASSFH---IHDGGKNTKNIwidGLGGDDNYILSTGFSKNnmreMKLWDLKNTTSALVTMS 258
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 169-193 2.84e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 2.84e-03
                           10        20
                   ....*....|....*....|....*
gi 1958749644  169 SCVAFSYDGNVLASRGGDDTLKLWD 193
Cdd:smart00320  16 TSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
169-193 4.58e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 4.58e-03
                          10        20
                  ....*....|....*....|....*
gi 1958749644 169 SCVAFSYDGNVLASRGGDDTLKLWD 193
Cdd:pfam00400  15 TSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-285 4.97e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 106.65  E-value: 4.97e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644  17 HQIKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMECIKG-------------DQYIV----------------DMANT- 66
Cdd:cd00200    10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGhtgpvrdvaasadGTYLAsgssdktirlwdletgECVRTl 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644  67 KGHTAMLHTGSWHPKikGEFM-TCSNDATVRLWEVENPKKQKsvfkprTMQGKKVIPTTCTYSRDGNLVAAACQNGSIQI 145
Cdd:cd00200    90 TGHTSYVSSVAFSPD--GRILsSSSRDKTIKVWDVETGKCLT------TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644 146 WD-------RNLTVHpkfhykqahapgTDT-SCVAFSYDGNVLASRGGDDTLKLWDVRQFN--KPLFSASDlptlfPMTD 215
Cdd:cd00200   162 WDlrtgkcvATLTGH------------TGEvNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKclGTLRGHEN-----GVNS 224

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644 216 CCFSPDDKLIVTGTsvqrgcGSGKLVFFERRTFQRVYEIHITDASVVRCLWHPKLNQIMVGTGNGLAKVY 285
Cdd:cd00200   225 VAFSPDGYLLASGS------EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
67-285 1.23e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.13  E-value: 1.23e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644  67 KGHTAMLHTGSWHPKikGEFM-TCSNDATVRLWEVENPKKqksvfkPRTMQGKKVIPTTCTYSRDGNLVAAACQNGSIQI 145
Cdd:COG2319   117 TGHTGAVRSVAFSPD--GKTLaSGSADGTVRLWDLATGKL------LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644 146 WD-------RNLTVHPKFHYkqahapgtdtsCVAFSYDGNVLASRGGDDTLKLWDVRQfNKPLFSASDLPtlFPMTDCCF 218
Cdd:COG2319   189 WDlatgkllRTLTGHTGAVR-----------SVAFSPDGKLLASGSADGTVRLWDLAT-GKLLRTLTGHS--GSVRSVAF 254

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958749644 219 SPDDKLIVTGTsvqrgcGSGKLVFFERRTFQRVYEIHITDASVVRCLWHPKLNQIMVGTGNGLAKVY 285
Cdd:COG2319   255 SPDGRLLASGS------ADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
19-285 1.40e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.13  E-value: 1.40e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644  19 IKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMecikgdqyivdmANTKGHTAMLHTGSWHPKikGEFM-TCSNDATVRL 97
Cdd:COG2319   165 VTSVAFSPDGKLLASGSDDGTVRLWDLATGKLL------------RTLTGHTGAVRSVAFSPD--GKLLaSGSADGTVRL 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644  98 WEVENPKKqksvfkPRTMQGKKVIPTTCTYSRDGNLVAAACQNGSIQIWDRNltvHPKFHYKQAHAPGTDTScVAFSYDG 177
Cdd:COG2319   231 WDLATGKL------LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA---TGELLRTLTGHSGGVNS-VAFSPDG 300

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644 178 NVLASRGGDDTLKLWDVRQfNKPLFSASDLPTlfPMTDCCFSPDDKLIVTGTSvqrgcgSGKLVFFERRTFQRVYEIHIT 257
Cdd:COG2319   301 KLLASGSDDGTVRLWDLAT-GKLLRTLTGHTG--AVRSVAFSPDGKTLASGSD------DGTVRLWDLATGELLRTLTGH 371

                         250       260
                  ....*....|....*....|....*...
gi 1958749644 258 DASVVRCLWHPKLNQIMVGTGNGLAKVY 285
Cdd:COG2319   372 TGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 67-285 7.05e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.40  E-value: 7.05e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644  67 KGHTAMLHTGSWHPKikGEFM-TCSNDATVRLWEVENPKKQksvfkpRTMQGKKVIPTTCTYSRDGNLVAAACQNGSIQI 145
Cdd:cd00200     6 KGHTGGVTCVAFSPD--GKLLaTGSGDGTIKVWDLETGELL------RTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644 146 WD-------RNLTVHPKfhykqahapgtDTSCVAFSYDGNVLASRGGDDTLKLWDVRQFN--KPLFSASDlptlfPMTDC 216
Cdd:cd00200    78 WDletgecvRTLTGHTS-----------YVSSVAFSPDGRILSSSSRDKTIKVWDVETGKclTTLRGHTD-----WVNSV 141

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958749644 217 CFSPDDKLIVTgtsvqrGCGSGKLVFFERRTFQRVYEIHITDASVVRCLWHPKLNQIMVGTGNGLAKVY 285
Cdd:cd00200   142 AFSPDGTFVAS------SSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-193 5.67e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 86.62  E-value: 5.67e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644   4 SFKAFRSLQPCECHQ--IKSLQYSNTGDMILVVSGSSQAKVIDrdgFEVMECIKgdqyivdmaNTKGHTAMLHTGSWHPK 81
Cdd:cd00200   121 DVETGKCLTTLRGHTdwVNSVAFSPDGTFVASSSQDGTIKLWD---LRTGKCVA---------TLTGHTGEVNSVAFSPD 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644  82 iKGEFMTCSNDATVRLWEVENPKKQKsvfkprTMQGKKVIPTTCTYSRDGNLVAAACQNGSIQIWD-RNLTVHPKFhykQ 160
Cdd:cd00200   189 -GEKLLSSSSDGTIKLWDLSTGKCLG------TLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDlRTGECVQTL---S 258

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1958749644 161 AHAPGTdtSCVAFSYDGNVLASRGGDDTLKLWD 193
Cdd:cd00200   259 GHTNSV--TSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
18-195 1.81e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.89  E-value: 1.81e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644  18 QIKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMECIKGdqyivdmantkgHTAMLHTGSWHPKikGEFM-TCSNDATVR 96
Cdd:COG2319   248 SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG------------HSGGVNSVAFSPD--GKLLaSGSDDGTVR 313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644  97 LWEVENPKKqksvfkPRTMQGKKVIPTTCTYSRDGNLVAAACQNGSIQIWDRN---LTVHPKFHYKQAHApgtdtscVAF 173
Cdd:COG2319   314 LWDLATGKL------LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAtgeLLRTLTGHTGAVTS-------VAF 380

                         170       180
                  ....*....|....*....|..
gi 1958749644 174 SYDGNVLASRGGDDTLKLWDVR 195
Cdd:COG2319   381 SPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
68-285 3.30e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.12  E-value: 3.30e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644  68 GHTAMLHTGSWHPKIKGeFMTCSNDATVRLWEVENPKKqksvfkPRTMQGKKVIPTTCTYSRDGNLVAAACQNGSIQIWD 147
Cdd:COG2319    76 GHTAAVLSVAFSPDGRL-LASASADGTVRLWDLATGLL------LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644 148 -------RNLTVHPKfhykqahapgtDTSCVAFSYDGNVLASRGGDDTLKLWDVRqfnkplfSASDLPTL----FPMTDC 216
Cdd:COG2319   149 latgkllRTLTGHSG-----------AVTSVAFSPDGKLLASGSDDGTVRLWDLA-------TGKLLRTLtghtGAVRSV 210

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958749644 217 CFSPDDKLIVTGTsvqrgcGSGKLVFFERRTFQRVYEIHITDASVVRCLWHPKLNQIMVGTGNGLAKVY 285
Cdd:COG2319   211 AFSPDGKLLASGS------ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 113-285 6.57e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.90  E-value: 6.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644 113 RTMQGKKVIPTTCTYSRDGNLVAAACQNGSIQIWDRNlTVHPKFHYKQAHAPGTDTSCVAfsyDGNVLASRGGDDTLKLW 192
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-TGELLRTLKGHTGPVRDVAASA---DGTYLASGSSDKTIRLW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644 193 DVRQfNKPLFsasdlpTLF----PMTDCCFSPDDKLIVTGTSvqrgcgSGKLVFFERRTFQRVYEIHITDASVVRCLWHP 268
Cdd:cd00200    79 DLET-GECVR------TLTghtsYVSSVAFSPDGRILSSSSR------DKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP 145

                         170
                  ....*....|....*..
gi 1958749644 269 KLNQIMVGTGNGLAKVY 285
Cdd:cd00200   146 DGTFVASSSQDGTIKLW 162
PTZ00420 PTZ00420
coronin; Provisional
 67-205 1.37e-08

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 56.88  E-value: 1.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644  67 KGHTAMLHTGSWHPKikGEFMTCSN--DATVRLWEVENPKKQKSVFKPRTMQGKKvipttctYSRDGNLVAAACQNGSIQ 144
Cdd:PTZ00420  122 KGHKKKISIIDWNPM--NYYIMCSSgfDSFVNIWDIENEKRAFQINMPKKLSSLK-------WNIKGNLLSGTCVGKHMH 192

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958749644 145 IWD-RNLTVHPKFHykqAHAPGTDTSCV---AFSYDGNVLASRGGDDT----LKLWDVRQFNKPLFSAS 205
Cdd:PTZ00420  193 IIDpRKQEIASSFH---IHDGGKNTKNIwidGLGGDDNYILSTGFSKNnmreMKLWDLKNTTSALVTMS 258
WD40 COG2319
WD40 repeat [General function prediction only];
127-285 7.90e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.98  E-value: 7.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644 127 YSRDGNLVAAACQNGSIQIWDRNLTVHPKfhykQAHAPGTDTSCVAFSYDGNVLASRGGDDTLKLWDVRQfnkPLFSASD 206
Cdd:COG2319    44 ASPDGARLAAGAGDLTLLLLDAAAGALLA----TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT---GLLLRTL 116

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958749644 207 LPTLFPMTDCCFSPDDKLIVTGTSvqrgcgSGKLVFFERRTFQRVYEIHITDASVVRCLWHPKLNQIMVGTGNGLAKVY 285
Cdd:COG2319   117 TGHTGAVRSVAFSPDGKTLASGSA------DGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 169-193 2.84e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 2.84e-03
                           10        20
                   ....*....|....*....|....*
gi 1958749644  169 SCVAFSYDGNVLASRGGDDTLKLWD 193
Cdd:smart00320  16 TSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 67-246 4.31e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.49  E-value: 4.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644  67 KGHTAMLHTGSWHPKIKGEFMTCSNDATVRLWEVENpKKQKSVFKPRTMQGkkvipTTCTYSRDGNLVAAACQNGSIQIW 146
Cdd:PTZ00421  122 QGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER-GKAVEVIKCHSDQI-----TSLEWNLDGSLLCTTSKDKKLNII 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749644 147 D-RNLTVhpkFHYKQAHAPGTDTSCVAFSYDGNVLA---SRGGDDTLKLWDVRQFNKPlFSASDL----PTLFPMtdccF 218
Cdd:PTZ00421  196 DpRDGTI---VSSVEAHASAKSQRCLWAKRKDLIITlgcSKSQQRQIMLWDTRKMASP-YSTVDLdqssALFIPF----F 267

                         170       180
                  ....*....|....*....|....*...
gi 1958749644 219 SPDDKLIVTGTSvqrgcGSGKLVFFERR 246
Cdd:PTZ00421  268 DEDTNLLYIGSK-----GEGNIRCFELM 290
WD40 pfam00400
WD domain, G-beta repeat;
169-193 4.58e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 4.58e-03
                          10        20
                  ....*....|....*....|....*
gi 1958749644 169 SCVAFSYDGNVLASRGGDDTLKLWD 193
Cdd:pfam00400  15 TSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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