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Conserved domains on  [gi|1958749210|ref|XP_038957693|]
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guanylate cyclase soluble subunit beta-1 isoform X2 [Rattus norvegicus]

Protein Classification

soluble guanylate cyclase( domain architecture ID 10542977)

soluble guanylate cyclase with a HNOB (Heme NO Binding) domain and a HNOBA (HNOB associated domain); similar to human guanylate cyclase soluble subunit beta-1 and Drosophila soluble guanylate cyclase 88

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HNOB pfam07700
Haem-NO-binding; The HNOB (Haem NO Binding) domain, is a predominantly alpha-helical domain ...
 2-166 1.63e-69

Haem-NO-binding; The HNOB (Haem NO Binding) domain, is a predominantly alpha-helical domain and binds heme via a covalent linkage to histidine. It is a haem protein sensor (SONO) that displays femtomolar affinity for nitrous oxide, NO. It is predicted to function as a haem-dependent sensor for gaseous ligands and to transduce diverse downstream signals in both bacteria and animals.


:

Pssm-ID: 462233  Cd Length: 162  Bit Score: 213.90  E-value: 1.63e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749210   2 YGFVNHALELLVIRNYGPEVWEDIKKEAQLdEEGQFLVRIIYDDSKTYDLVAAASKVLNLNAGEILQMFGKMFFVFCQES 81
Cdd:pfam07700   1 YGIVFEALQDLVEEKYGEEVWDEILEKAGL-EEGVFTPHETYDDEETLKLVEAAAKVTGLSVDELLEAFGRFFIKFFAES 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749210  82 GYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRCTDaEKGKGLILHYYSEREGLQDIVIGIIKTVAqQIHGTE 161
Cdd:pfam07700  80 GYPRFFKVLGRNLFDFLNNLDNLHEVLKLSYPGMKPPSFRCEE-ESDGGLVLHYYSKRKGLFPYVLGLLEGAA-EFFNED 157


                  ....*
gi 1958749210 162 IDMKV 166
Cdd:pfam07700 158 VEIEV 162
HNOBA super family cl06648
Heme NO binding associated; The HNOBA domain is found associated with the HNOB domain and ...
 207-327 1.97e-41

Heme NO binding associated; The HNOBA domain is found associated with the HNOB domain and pfam00211 in soluble cyclases and signalling proteins. The HNOB domain is predicted to function as a heme-dependent sensor for gaseous ligands, and transduce diverse downstream signals, in both bacteria and animals.


The actual alignment was detected with superfamily member pfam07701:

Pssm-ID: 462234  Cd Length: 214  Bit Score: 143.48  E-value: 1.97e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749210 207 RISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVLPQLQPGKCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLD 286
Cdd:pfam07701   2 PISSDVFFRLFPFHVVFDRDMKIVSAGSSLARVFPDPDLIGKKLTDVFRLRRPLIEFTFDNILQHINVVFELQTKRPLLR 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958749210 287 VEK------------LECEDELTGAEISCLRLKGQMIYLPEADSILFLCSPRI 327
Cdd:pfam07701  82 KEEeaklsaaldaseEESSSDLSEESSRNLKLKGQMRYLPEWDSILFLCSPVV 134
 
Name Accession Description Interval E-value
HNOB pfam07700
Haem-NO-binding; The HNOB (Haem NO Binding) domain, is a predominantly alpha-helical domain ...
 2-166 1.63e-69

Haem-NO-binding; The HNOB (Haem NO Binding) domain, is a predominantly alpha-helical domain and binds heme via a covalent linkage to histidine. It is a haem protein sensor (SONO) that displays femtomolar affinity for nitrous oxide, NO. It is predicted to function as a haem-dependent sensor for gaseous ligands and to transduce diverse downstream signals in both bacteria and animals.


Pssm-ID: 462233  Cd Length: 162  Bit Score: 213.90  E-value: 1.63e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749210   2 YGFVNHALELLVIRNYGPEVWEDIKKEAQLdEEGQFLVRIIYDDSKTYDLVAAASKVLNLNAGEILQMFGKMFFVFCQES 81
Cdd:pfam07700   1 YGIVFEALQDLVEEKYGEEVWDEILEKAGL-EEGVFTPHETYDDEETLKLVEAAAKVTGLSVDELLEAFGRFFIKFFAES 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749210  82 GYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRCTDaEKGKGLILHYYSEREGLQDIVIGIIKTVAqQIHGTE 161
Cdd:pfam07700  80 GYPRFFKVLGRNLFDFLNNLDNLHEVLKLSYPGMKPPSFRCEE-ESDGGLVLHYYSKRKGLFPYVLGLLEGAA-EFFNED 157


                  ....*
gi 1958749210 162 IDMKV 166
Cdd:pfam07700 158 VEIEV 162
HNOBA pfam07701
Heme NO binding associated; The HNOBA domain is found associated with the HNOB domain and ...
 207-327 1.97e-41

Heme NO binding associated; The HNOBA domain is found associated with the HNOB domain and pfam00211 in soluble cyclases and signalling proteins. The HNOB domain is predicted to function as a heme-dependent sensor for gaseous ligands, and transduce diverse downstream signals, in both bacteria and animals.


Pssm-ID: 462234  Cd Length: 214  Bit Score: 143.48  E-value: 1.97e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749210 207 RISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVLPQLQPGKCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLD 286
Cdd:pfam07701   2 PISSDVFFRLFPFHVVFDRDMKIVSAGSSLARVFPDPDLIGKKLTDVFRLRRPLIEFTFDNILQHINVVFELQTKRPLLR 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958749210 287 VEK------------LECEDELTGAEISCLRLKGQMIYLPEADSILFLCSPRI 327
Cdd:pfam07701  82 KEEeaklsaaldaseEESSSDLSEESSRNLKLKGQMRYLPEWDSILFLCSPVV 134
 
Name Accession Description Interval E-value
HNOB pfam07700
Haem-NO-binding; The HNOB (Haem NO Binding) domain, is a predominantly alpha-helical domain ...
 2-166 1.63e-69

Haem-NO-binding; The HNOB (Haem NO Binding) domain, is a predominantly alpha-helical domain and binds heme via a covalent linkage to histidine. It is a haem protein sensor (SONO) that displays femtomolar affinity for nitrous oxide, NO. It is predicted to function as a haem-dependent sensor for gaseous ligands and to transduce diverse downstream signals in both bacteria and animals.


Pssm-ID: 462233  Cd Length: 162  Bit Score: 213.90  E-value: 1.63e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749210   2 YGFVNHALELLVIRNYGPEVWEDIKKEAQLdEEGQFLVRIIYDDSKTYDLVAAASKVLNLNAGEILQMFGKMFFVFCQES 81
Cdd:pfam07700   1 YGIVFEALQDLVEEKYGEEVWDEILEKAGL-EEGVFTPHETYDDEETLKLVEAAAKVTGLSVDELLEAFGRFFIKFFAES 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749210  82 GYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRCTDaEKGKGLILHYYSEREGLQDIVIGIIKTVAqQIHGTE 161
Cdd:pfam07700  80 GYPRFFKVLGRNLFDFLNNLDNLHEVLKLSYPGMKPPSFRCEE-ESDGGLVLHYYSKRKGLFPYVLGLLEGAA-EFFNED 157


                  ....*
gi 1958749210 162 IDMKV 166
Cdd:pfam07700 158 VEIEV 162
HNOBA pfam07701
Heme NO binding associated; The HNOBA domain is found associated with the HNOB domain and ...
 207-327 1.97e-41

Heme NO binding associated; The HNOBA domain is found associated with the HNOB domain and pfam00211 in soluble cyclases and signalling proteins. The HNOB domain is predicted to function as a heme-dependent sensor for gaseous ligands, and transduce diverse downstream signals, in both bacteria and animals.


Pssm-ID: 462234  Cd Length: 214  Bit Score: 143.48  E-value: 1.97e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958749210 207 RISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVLPQLQPGKCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLD 286
Cdd:pfam07701   2 PISSDVFFRLFPFHVVFDRDMKIVSAGSSLARVFPDPDLIGKKLTDVFRLRRPLIEFTFDNILQHINVVFELQTKRPLLR 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958749210 287 VEK------------LECEDELTGAEISCLRLKGQMIYLPEADSILFLCSPRI 327
Cdd:pfam07701  82 KEEeaklsaaldaseEESSSDLSEESSRNLKLKGQMRYLPEWDSILFLCSPVV 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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