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Conserved domains on  [gi|1958642650|ref|XP_038957459|]
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neuromedin-B receptor isoform X1 [Rattus norvegicus]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
44-335 0e+00

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15125:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 292  Bit Score: 548.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  44 CVIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQ 123
Cdd:cd15125     1 CVIPSLYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRYFYEEWMFGTVGCKLIPVIQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACIPYPQ 203
Cdd:cd15125    81 LTSVGVSVFTLTALSADRYKAIVNPMDIQTSSAVLRTCLKAIAIWVVSVLLAVPEAVFSEVAHIMPDDNTTFTACIPYPQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNH 283
Cdd:cd15125   161 TDEMHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNIPGEYSEHSKRQMETRKRLAKIVLVFVGLFAFCWFPNH 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958642650 284 ILYLYRSFNYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15125   241 VLYMYRSFNYNEIDSSLGHMIVTLVARVLSFCNSCVNPFALYLLSESFRRHF 292
 
Name Accession Description Interval E-value
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
44-335 0e+00

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 548.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  44 CVIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQ 123
Cdd:cd15125     1 CVIPSLYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRYFYEEWMFGTVGCKLIPVIQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACIPYPQ 203
Cdd:cd15125    81 LTSVGVSVFTLTALSADRYKAIVNPMDIQTSSAVLRTCLKAIAIWVVSVLLAVPEAVFSEVAHIMPDDNTTFTACIPYPQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNH 283
Cdd:cd15125   161 TDEMHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNIPGEYSEHSKRQMETRKRLAKIVLVFVGLFAFCWFPNH 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958642650 284 ILYLYRSFNYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15125   241 VLYMYRSFNYNEIDSSLGHMIVTLVARVLSFCNSCVNPFALYLLSESFRRHF 292
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
60-322 1.07e-56

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 186.35  E-value: 1.07e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  60 GNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFF-DEWVFGKLGCKLIPAIQLTSVGVSVFTLTALS 138
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 139 ADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVariGSSDNSSFTACIPYPQTDELHPKIHSVLIFL 218
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWT---LTVPEGNVTVCFIDFPEDLSKPVSYTLLISV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 219 VYFLIPLVIISIYYYHIAKTLIRSAHnlpgeyNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNHILYLYRSFNyKEIDP 298
Cdd:pfam00001 158 LGFLLPLLVILVCYTLIIRTLRKSAS------KQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLA-LDCEL 230
                         250       260
                  ....*....|....*....|....
gi 1958642650 299 SLGHMIVTLVARVLSFSNSCVNPF 322
Cdd:pfam00001 231 SRLLDKALSVTLWLAYVNSCLNPI 254
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
46-334 7.17e-25

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 103.70  E-value: 7.17e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNImLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIPAIQLT 125
Cdd:PHA03087   43 LIVVYSTIFFFGLVGNI-IVIYVLTKTKIKTPMDIYLLNLAVSDLLFVMT-LPFQIYYYILFQWSFGEFACKIVSGLYYI 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 126 SVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVarigSSDNSSFTACIPYPQTD 205
Cdd:PHA03087  121 GFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTT----KKDHETLICCMFYNNKT 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 206 ELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNlpgeynehTKKqmetrKRLAKIVLVFVGCFVFCWFPNH-- 283
Cdd:PHA03087  197 MNWKLFINFEINIIGMLIPLTILLYCYSKILITLKGINKS--------KKN-----KKAIKLVLIIVILFVIFWLPFNvs 263
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 284 -ILYLYRSFNYKEIDPSLGHMIVTL-VARVLSFSNSCVNPFALYLLSESFRKH 334
Cdd:PHA03087  264 vFVYSLHILHFKSGCKAVKYIQYALhVTEIISLSHCCINPLIYAFVSEFFNKH 316
 
Name Accession Description Interval E-value
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
44-335 0e+00

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 548.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  44 CVIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQ 123
Cdd:cd15125     1 CVIPSLYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRYFYEEWMFGTVGCKLIPVIQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACIPYPQ 203
Cdd:cd15125    81 LTSVGVSVFTLTALSADRYKAIVNPMDIQTSSAVLRTCLKAIAIWVVSVLLAVPEAVFSEVAHIMPDDNTTFTACIPYPQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNH 283
Cdd:cd15125   161 TDEMHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNIPGEYSEHSKRQMETRKRLAKIVLVFVGLFAFCWFPNH 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958642650 284 ILYLYRSFNYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15125   241 VLYMYRSFNYNEIDSSLGHMIVTLVARVLSFCNSCVNPFALYLLSESFRRHF 292
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
44-335 7.64e-146

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 415.13  E-value: 7.64e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  44 CVIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQ 123
Cdd:cd15927     1 YVVPILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLDSWPFGEFLCKLSEFLK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACIPYPQ 203
Cdd:cd15927    81 DTSIGVSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPEAIFSHVVTFTLTDNQTIQICYPYPQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 T-DELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPN 282
Cdd:cd15927   161 ElGPNYPKIMVLLRFLVYYLIPLLIIGVFYVLMARHLIRSTRNIGSGQNQAAQRQIEARKKVAKTVLAFVVLFAVCWLPR 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958642650 283 HILYLYRSFNYKE-IDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15927   241 HVFMLWFHFAPNGlVDYNAFWHVLKIVGFCLSFINSCVNPVALYLLSGSFRRHF 294
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
45-335 1.51e-137

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 394.27  E-value: 1.51e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15124     2 AIPTVYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPFIQL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIG-SSDNSSFTACIPYPQ 203
Cdd:cd15124    82 TSVGVSVFTLTALSADRYKAIVRPMDIQASNALMKICLKAALIWILSMLLAIPEAVFSDLHPFYdKSTNKTFVSCAPYPH 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNH 283
Cdd:cd15124   162 SNELHPKIHSMASFLIFYVIPLSIISVYYYFIAKNLIRSAYNLPVEGNVHVRRQIESRKRLAKTVLVFVGLFAFCWLPNH 241
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958642650 284 ILYLYRSFNYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15124   242 IIYLYRSYHYSEVDTSMLHFVSSICARILAFTNSCVNPFALYLLSKSFRKQF 293
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
44-335 4.28e-131

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 377.72  E-value: 4.28e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  44 CVIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQ 123
Cdd:cd15123     1 CAIYVTYAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRYIADTWLFGRIGCKLLSFIQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSD-NSSFTACIPYP 202
Cdd:cd15123    81 LTSVGVSVFTLTVLSADRYRAIVKPLELQTSDAVLKTCCKAGCVWIVSMLFAIPEAVFSDLYSFRDPEkNTTFEACAPYP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 203 QTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPN 282
Cdd:cd15123   161 VSEKILQEIHSLLCFLVFYIIPLSIISVYYFLIARTLYKSTFNMPAEEHSHARKQIESRKRVAKTVLVLVALFAFCWLPN 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958642650 283 HILYLYRSFNYKE-IDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15123   241 HILYLYRSFTYHTsVDSSAFHLIATIFSRVLAFSNSCVNPFALYWLSKSFRQHF 294
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
44-335 1.73e-130

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 375.99  E-value: 1.73e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  44 CVIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQ 123
Cdd:cd14977     1 YVIMSLSLVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKDWLFGDVMCKLVPFIQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACIPYPQ 203
Cdd:cd14977    81 VTSLGVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVLSTVARESSLDNSSLTVCIMKPS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 T--DELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHnlpgEYNEHTKKQMETRKRLAKIVLVFVGCFVFCWFP 281
Cdd:cd14977   161 TpfAETYPKARSWWLFGCYFCLPLAFTAVCYLLMARTLIRAAK----EYTRGTKKHMKQRRQLAKTVLCLVLVFAFCWLP 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 282 NHILYLYRSFNYKE--IDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd14977   237 EHISNILRATLYNEvlIDTRSTLDILDLIGQFLSFFNSCVNPIALYLLSEPFRRAF 292
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
44-335 1.64e-62

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 202.44  E-value: 1.64e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  44 CVIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQ 123
Cdd:cd14993     1 IVLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQtsgvVLWTSLKA----VGIWVVSVLLAVPEAVFSEVARIGSS--DNSSFTA 197
Cdd:cd14993    81 GVSVSASVLTLVAISIDRYLAICYPLKAR----RVSTKRRAriiiVAIWVIAIIIMLPLLVVYELEEIISSepGTITIYI 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 198 CIP-YPQTDelHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTK--KQMETRKRLAKIVLVFVGC 274
Cdd:cd14993   157 CTEdWPSPE--LRKAYNVALFVVLYVLPLLIISVAYSLIGRRLWRRKPPGDRGSANSTSsrRILRSKKKVARMLIVVVVL 234
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958642650 275 FVFCWFPNHILYLYRSFNYKEI-DPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd14993   235 FALSWLPYYVLSILLDFGPLSSeESDENFLLILPFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
49-322 7.32e-57

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 187.11  E-value: 7.32e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd00637     4 LYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVarigssDNSSFTACIPYPQTDELH 208
Cdd:cd00637    84 ASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGV------YDYGGYCCCCLCWPDLTL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 209 PKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEY-NEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNHILYL 287
Cdd:cd00637   158 SKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSsNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLL 237
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1958642650 288 YRSFNYkeiDPSLGHMIVTLVARVLSFSNSCVNPF 322
Cdd:cd00637   238 LDVFGP---DPSPLPRILYFLALLLAYLNSAINPI 269
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
60-322 1.07e-56

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 186.35  E-value: 1.07e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  60 GNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFF-DEWVFGKLGCKLIPAIQLTSVGVSVFTLTALS 138
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 139 ADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVariGSSDNSSFTACIPYPQTDELHPKIHSVLIFL 218
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWT---LTVPEGNVTVCFIDFPEDLSKPVSYTLLISV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 219 VYFLIPLVIISIYYYHIAKTLIRSAHnlpgeyNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNHILYLYRSFNyKEIDP 298
Cdd:pfam00001 158 LGFLLPLLVILVCYTLIIRTLRKSAS------KQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLA-LDCEL 230
                         250       260
                  ....*....|....*....|....
gi 1958642650 299 SLGHMIVTLVARVLSFSNSCVNPF 322
Cdd:pfam00001 231 SRLLDKALSVTLWLAYVNSCLNPI 254
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
48-335 2.91e-54

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 181.26  E-value: 2.91e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  48 SLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSV 127
Cdd:cd15203     5 LLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFGSILCKLVPSLQGVSI 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPM--DMQTSGVVLWTslkaVGIWVVSVLLAVPEAVFSEVARI-GSSDNSSFTACI---Py 201
Cdd:cd15203    85 FVSTLTLTAIAIDRYQLIVYPTrpRMSKRHALLII----ALIWILSLLLSLPLAIFQELSDVpIEILPYCGYFCTeswP- 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 202 pqtDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPG-EYNEHTKKQMETR--KRLAKIVLVFVGCFVFC 278
Cdd:cd15203   160 ---SSSSRLIYTISVLVLQFVIPLLIISFCYFRISLKLRKRVKKKRGkRTLSSRRRRSELRrkRRTNRLLIAMVVVFAVC 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958642650 279 WFPNHILYLYRSFNYKEIDPSLGHMIVTLVARVLSFSNSCVNPFaLY-LLSESFRKHF 335
Cdd:cd15203   237 WLPLNLFNLLRDFEPLPQIDGRHFYLIFLICHLIAMSSACVNPL-LYgWLNDNFRKEF 293
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
45-335 9.86e-53

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 177.09  E-value: 9.86e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15095     2 LVPLIFAIIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPFTAALYATPSWVFGDFMCKFVNYMMQ 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNP---MDMQTSGVVLWTSlkaVGIWVVSVLLAVPEAVFSEVarIGSSDNSSFTACIPY 201
Cdd:cd15095    82 VTVQATCLTLTALSVDRYYAIVHPirsLRFRTPRVAVVVS---ACIWIVSFLLSIPVAIYYRL--EEGYWYGPQTYCREV 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 202 pQTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFVFCWFP 281
Cdd:cd15095   157 -WPSKAFQKAYMIYTVLLTYVIPLAIIAVCYGLILRRLWRRSVDGNNQSEQLSERALRQKRKVTRMVIVVVVLFAICWLP 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958642650 282 NHILYLYRSFNyKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15095   236 NHVLNLWQRFD-PNFPETYATYALKIAALCLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
44-335 3.23e-49

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 167.80  E-value: 3.23e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  44 CVIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQ 123
Cdd:cd15207     1 VLFIVSYSLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDNILTGWPFGDVMCKLSPLVQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSG-VVLWTslkAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACIPYP 202
Cdd:cd15207    81 GVSVAASVFTLVAIAVDRYRAVVHPTEPKLTNrQAFVI---IVAIWVLALAIMIPQALVLEVKEYQFFRGQTVHICVEFW 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 203 QTDElHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTL-IRSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFVFCWFP 281
Cdd:cd15207   158 PSDE-YRKAYTTSLFVLCYVAPLLIIAVLYVRIGYRLwFKPVPGGGSASREAQAAVSKKKVRVIKMLIVVVVLFALSWLP 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958642650 282 NHILYLYRSF-NYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15207   237 LHTVTMLDDFgNLSPNQREVLYVYIYPIAHWLAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
52-335 7.83e-48

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 164.62  E-value: 7.83e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVD-----ASRYFFDEWVFGKLGCKLIPAIQLTS 126
Cdd:cd15128     9 LIFIVGIIGNSTLLRIIYQNKCMRNGPNALIASLALGDLLYIVIDLPINvykllAMDWPFGDQPFGQFLCKLVPFIQKAS 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 127 VGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSdNSSFTACIPYPQTD- 205
Cdd:cd15128    89 VGITVLNLCALSVDRYRAVASWSRIQGIGIPMWTAVEIVMIWMLSAVLAVPEAIGFDMVRFNYK-GVTLRTCLLRPETSf 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 206 -ELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHnlpGEYNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNHI 284
Cdd:cd15128   168 mKFYIDVKDWWLFGFYFCLPLVCTAIFYTLMTCEMLRKRN---GMLRIALNEHLKQRREVAKTVFCLVVIFALCWLPLHL 244
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 285 LYLYRSFNYKEIDPSLGHMIVTL-----VARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15128   245 SRILKLTVYDQNDPNRCELLSFLlvldyFGINLATLNSCINPIALYFVSRKFKNCF 300
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
45-335 2.24e-47

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 162.97  E-value: 2.24e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTM--RSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAI 122
Cdd:cd15098     2 IVPVVFGLIFCLGVLGNSLVITVLARVKPGkrRSTTNVFILNLSIADLFFLLFCVPFQATIYSLPEWVFGAFMCKFVHYF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 123 QLTSVGVSVFTLTALSADRYRAIVNPmdMQTSGVVLWTS-LKAVG-IWVVSVLLAVPEAVFSEVARIGSSDNSSFtaCIP 200
Cdd:cd15098    82 FTVSMLVSIFTLVAMSVDRYIAVVHS--RTSSSLRTRRNaLLGVLvIWVLSLAMASPVAVHQDLVHHWTASNQTF--CWE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 201 YpQTDELHPKIHSVLIFLVYFLIPLVIISIYYyhiAKTLirsaHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFVFCWF 280
Cdd:cd15098   158 N-WPEKQQKPVYVVCTFVFGYLLPLLLITFCY---AKVL----NHLHKKLKNMSKKSERSKKKTAQTVLVVVVVFGISWL 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958642650 281 PNHILYLYRSFNYKEIDPSlgHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15098   230 PHHIIHLWVEFGDFPLTQA--SFVLRITAHCLAYANSCVNPIIYAFLSENFRKAY 282
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
50-333 6.59e-47

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 161.74  E-value: 6.59e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  50 YLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGV 129
Cdd:cd15389     7 YSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQYCSVYV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 130 SVFTLTALSADRYRAIVNP----MDMQTSGVVLwtslkaVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACIP-YPQT 204
Cdd:cd15389    87 STLTLTAIALDRHRVILHPlkprITPCQGVVVI------AIIWIMASCLSLPHAIYQKLVEFEYSNERTRSRCLPsFPEP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRsaHNLPGEYNEHTK-KQMETRKRLAKIVLVFVGCFVFCWFP-- 281
Cdd:cd15389   161 SDLFWKYLDLATFILQYVLPLLIIGVAYTRVAKKLWL--RNAIGDVTTEQYvAQRRKKKKTIKMLMLVVLLFAICWLPln 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 282 -NHILYLYRSFNYkeidpslgHMIVTLVARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15389   239 cYHVLLSSHPIRS--------NSALFFAFHWLAMSSTCYNPFIYCWLNDSFRS 283
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
45-335 9.80e-47

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 161.09  E-value: 9.80e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd14971     2 IVPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQ 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNP---MDMQTSGVVLwtsLKAVGIWVVSVLLAVPEAVfseVARIGSSDNSSFTACIPy 201
Cdd:cd14971    82 VSMHASIFTLVAMSLDRFLAVVYPlrsLHIRTPRNAL---AASGCIWVVSLAVAAPVLA---LHRLRNYTPGNRTVCSE- 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 202 PQTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGeynehTKKQMETRKRLAKIVLVFVGCFVFCWFP 281
Cdd:cd14971   155 AWPSRAHRRAFALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVRPVL-----SEGSRRAKRKVTRLVLVVVVLFAACWGP 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958642650 282 NHILYLYRSFNYKEIDPSlgHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd14971   230 IHAILLLVALGPFPLTYA--TYALRIWAHCLAYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
49-335 1.07e-46

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 161.13  E-value: 1.07e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd15202     6 AYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSVH 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPMDMQTSgvVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACIP-YPQTDEL 207
Cdd:cd15202    86 VSAYTLTAIAVDRYQAIMHPLKPRIS--KTKAKFIIAVIWTLALAFALPHAICSKLETFKYSEDIVRSLCLEdWPERADL 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 208 HPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLirSAHNLPGE-YNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNHILY 286
Cdd:cd15202   164 FWKYYDLALFILQYFLPLLVISFAYARVGIKL--WASNMPGDaTTERYFALRRKKKKVIKMLMVVVVLFALCWLPFNIYV 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1958642650 287 LYRSFNYKEIDPSLGhmIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15202   242 LLLSSKPDYLIKTIN--AVYFAFHWLAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
52-335 2.32e-46

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 160.80  E-value: 2.32e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVD-----ASRYFFDEWVFGKLGCKLIPAIQLTS 126
Cdd:cd15975     9 IIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYIVIDIPINvykllAQKWPFDDSSFGVFLCKLVPFLQKAS 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 127 VGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIgSSDNSSFTACIPYPQTD- 205
Cdd:cd15975    89 VGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIFSIWVLSFILAIPEAIGFVMVPF-EYNGEQYRTCMLNATTKf 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 206 -ELHPKIHSVLIFLVYFLIPLVIISIYYYHIA-KTLIRSAHNLPGEYNEHTKKqmetRKRLAKIVLVFVGCFVFCWFPNH 283
Cdd:cd15975   168 mNFYVDAKDWWLFGFYFCVPLACTAIFYTLMTcEMLNRRKGSLRIALSEHLKQ----RREVAKTVFCLVVIFALCWFPLH 243
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642650 284 ILYLYRSFNYKEIDPSLGHMIVTL-----VARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15975   244 LSRILKKTVYNENDPRRCELLSFLlvmdyISINLATMNSCINPIALYFVSKKFKNCF 300
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
52-335 3.01e-46

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 160.40  E-value: 3.01e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSV 131
Cdd:cd15976     9 LVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 132 FTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIgSSDNSSFTACIPYPQTD----EL 207
Cdd:cd15976    89 LSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSIILAVPEAIGFDMITM-DYKGELLRICLLHPIQKtafmQF 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 208 HPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTKKqmetRKRLAKIVLVFVGCFVFCWFPNHILYL 287
Cdd:cd15976   168 YKTAKDWWLFSFYFCLPLACTAVFYTLMTCEMLRKKNGMQIALNDHLKQ----RREVAKTVFCLVLVFALCWLPLHLSRI 243
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 288 YRSFNYKEIDPSLGH-----MIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15976   244 LKLTIYDEKDPNRCEllsffLVLDYIGINMASLNSCINPIALYLVSKRFKNCF 296
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
45-335 3.70e-46

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 160.25  E-value: 3.70e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVP----VDASryffDEWVFGKLGCKLIP 120
Cdd:cd15208     2 VLIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPatllVDVT----ETWFFGQVLCKIIP 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 121 AIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLkaVGIWVVSVLLAVPEAVFSEVARIGSSDN--SSFTAC 198
Cdd:cd15208    78 YLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARVSI--LIIWIVSLLIMIPQAIVMECSRVVPLANktILLTVC 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 199 ipYPQ-TDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSahNLPGE-------YNEHTK-------KQMETRKR 263
Cdd:cd15208   156 --DERwSDSIYQKVYHICFFLVTYLLPLCLMILAYFQIFRKLWCR--QIPGTssvvqrkWNKPRKsavaaeeKQLRSRRK 231
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 264 LAKIVLVFVGCFVFCWFPNHIL-YLYRSFNYKEIDPSLGHmIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15208   232 TAKMLIVVVIMFAICYLPVHLLnILRYVFGLFTVDRETIY-AWFLFSHWLVYANSAINPIIYNFMSGKFREEF 303
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
45-335 1.54e-45

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 158.23  E-value: 1.54e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15096     2 VVPVIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNP---MDMQTSGVVLWTslkAVGIWVVSVLLAVPEAVFSEVaRIGSSDNSSFTACIpY 201
Cdd:cd15096    82 VTAYASVYTLVLMSLDRYLAVVHPitsMSIRTERNTLIA---IVGIWIVILVANIPVLFLHGV-VSYGFSSEAYSYCT-F 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 202 PQTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTKKqmetRKRLAKIVLVFVGCFVFCWFP 281
Cdd:cd15096   157 LTEVGTAAQTFFTSFFLFSYLIPLTLICVLYMLMLRRLRRQKSPGGRRSAESQRG----KRRVTRLVVVVVVVFAICWLP 232
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958642650 282 NHILYLYRSFNYKEIdpSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15096   233 IHIILLLKYYGVLPE--TVLYVVIQILSNCLAYGNSCVNPILYAFLSQNFRKAF 284
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
49-335 1.65e-45

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 158.23  E-value: 1.65e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd15390     6 VFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITTVA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPMDMQTSGVVlwTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACI------PYP 202
Cdd:cd15390    86 ASVFTLMAISIDRYIAIVHPLRPRLSRRT--TKIAIAVIWLASFLLALPQLLYSTTETYYYYTGSERTVCFiawpdgPNS 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 203 QTDELHpkiHSVLIFLVYFLiPLVIISIYYYHIAKTLIRSahNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPN 282
Cdd:cd15390   164 LQDFVY---NIVLFVVTYFL-PLIIMAVAYTRVGVELWGS--KTIGENTPRQLESVRAKRKVVKMMIVVVVIFAICWLPY 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 283 HILYLYRSFnYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15390   238 HLYFILTYL-YPDINSWKYIQQIYLAIYWLAMSNSMYNPIIYCWMNKRFRYGF 289
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
52-335 6.74e-45

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 156.99  E-value: 6.74e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSV 131
Cdd:cd15977     9 VIFLVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLYILIAIPINVIKLIAEDWPFGVHVCKLYPFIQKASVGITV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 132 FTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACIPYPQTDE---LH 208
Cdd:cd15977    89 LSLCALSIDRYRAVASWSRIRGIGIPVWKAVEVTLIWAVAIIVAVPEAIAFDMVEIDYRGQTLLVCMLPMEQTSSfmrFY 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 209 PKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHtkkqMETRKRLAKIVLVFVGCFVFCWFPNHILYLY 288
Cdd:cd15977   169 QDVKDWWLFGFYFCLPLACTGVFYTLMSCEMLSIKNGMRIALNDH----MKQRREVAKTVFCLVVIFALCWLPLHLSRIL 244
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958642650 289 RSFNYKEIDPSLGH-----MIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15977   245 KKTIYDVKDPQRCEllsflLVMDYTGINMASLNSCINPVALYFVSRKFKNCF 296
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
45-335 3.13e-44

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 154.90  E-value: 3.13e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd14992     2 ILGVALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACIPYPQ- 203
Cdd:cd14992    82 VSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLFSVKNQEKIFCCQIPPv 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLirSAHNLPGE-YNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPN 282
Cdd:cd14992   162 DNKTYEKVYFLLIFVVIFVLPLIVMTLAYARISREL--WFRKVPGFsIKEVERKRLKCKRRVIKMLVCVVVLFVICWLPF 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 283 HILYLYRSFNyKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd14992   240 HLFFLLRDFF-PLIMKEKHTLQVYYFLHWIAMSNSMYNPIIYVTLNNNFRKNF 291
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
49-335 5.20e-44

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 154.10  E-value: 5.20e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd15393     6 LYGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQVLSVN 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPMDMQTSGVVlwTSLKAVGIWVVSVLLAVPEAVFSEVAR-IGSSDNSSFTACIPYPQTDEL 207
Cdd:cd15393    86 VSVFTLTVIAVDRYRAVIHPLKARCSKKS--AKIIILIIWILALLVALPVALALRVEElTDKTNNGVKPFCLPVGPSDDW 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 208 HpKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSahNLPGEYNEHTKKQM-ETRKRLAKIVLVFVGCFVFCWFPNHiLY 286
Cdd:cd15393   164 W-KIYNLYLVCVQYFVPLVIICYAYTRIAVKIWGT--KAPGNAQDVRDDEIlKNKKKVIKMLIIVVALFALCWLPLQ-TY 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1958642650 287 LYRSFNYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15393   240 NLLNEIKPEINKYKYINIIWFCSHWLAMSNSCYNPFIYGLYNEKFKREF 288
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
45-335 6.16e-44

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 153.69  E-value: 6.16e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFD-EWVFGKLGCKLIPAIQ 123
Cdd:cd14985     2 VIPALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLT-LPLWATYTANQyDWPFGAFLCKVSSYVI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIgssDNSSFTACIPYPQ 203
Cdd:cd14985    81 SVNMFASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRSLQAI---ENLNKTACIMLYP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELHPKIhSVLIFLVYFLIPLVIISIYYYHIAKTLIRSahnlpgeyNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNH 283
Cdd:cd14985   158 HEAWHFGL-SLELNILGFVLPLLIILTCYFHIARSLRKR--------YERTGKNGRKRRKSLKIIFALVVAFLVCWLPFH 228
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 284 IL-YLYRSFNYKEIDPSLGHMIVTL---VARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd14985   229 FFkFLDFLAQLGAIRPCFWELFLDLglpIATCLAFTNSCLNPFIYVFVDRRFRQKV 284
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
45-334 1.24e-43

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 152.97  E-value: 1.24e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPsLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASrYFFDE--WVFGKLGCKLIPAI 122
Cdd:cd15394     3 IIP-LYSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLA-YAFEPrgWVFGRFMCYFVFLM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 123 QLTSVGVSVFTLTALSADRYRAIVNP----MDMQTSGVVLwtslkaVGIWVVSVLLAVPEAVFSEVARIGSSDnssFTAC 198
Cdd:cd15394    81 QPVTVYVSVFTLTAIAVDRYYVTVYPlrrrISRRTCAYIV------AAIWLLSCGLALPAAAHTYYVEFKGLD---FSIC 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 199 IPYPQTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRsaHNLPGE-YNEHTKKQMETRKRLAKIVLVFVGCFVF 277
Cdd:cd15394   152 EEFWFGQEKQRLAYACSTLLITYVLPLLAISLSYLRISVKLRN--RVVPGSmTQSQAEWDRARRRKTFRLLVVVVVAFAI 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642650 278 CWFPNHILYLYRSFNYKEIDPSLGHMIvTLVARVLSFSNSCVNPFALYLLSESFRKH 334
Cdd:cd15394   230 CWLPLHIFNVIRDIDIDLIDKQYFNLI-QLLCHWLAMSSACYNPFLYAWLHDSFRGE 285
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
50-335 3.19e-43

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 151.27  E-value: 3.19e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  50 YLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGV 129
Cdd:cd15001     6 YVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLSFIC 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 130 SVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACIPYpQTDELHP 209
Cdd:cd15001    86 SVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVRYESENGVTVYHCQKA-WPSTLYS 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 210 KIHSVLIFLVYFLIPLVIISIYYYHiaktlirsahnlpgeynehtkkqmETRKRLAKIVLVFVGCFVFCWFPNHILYLYR 289
Cdd:cd15001   165 RLYVVYLAIVIFFIPLIVMTFAYAR------------------------DTRKQVIKMLISVVVLFAVCWGPLLIDNLLV 220
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1958642650 290 SFNYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15001   221 SFDVISTLHTQALKYMRIAFHLLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
45-335 1.13e-42

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 150.52  E-value: 1.13e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd14970     2 VIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLG-LPFLATSYLLGYWPFGEVMCKIVLSVDA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPM---DMQTSGVVLWTSLkavGIWVVSVLLAVPEAVFSEVARIgSSDNSSFTACIP- 200
Cdd:cd14970    81 YNMFTSIFCLTVMSVDRYLAVVHPVkslRFRTPRKAKLVSL---CVWALSLVLGLPVIIFARTLQE-EGGTISCNLQWPd 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 201 YPQTDELHPKIHSvliFLVYFLIPLVIISIYYYHIAKTLiRSAHNLPgeyNEHTKKQMETRKRLAKIVLVFVGCFVFCWF 280
Cdd:cd14970   157 PPDYWGRVFTIYT---FVLGFAVPLLVITVCYSLIIRRL-RSSRNLS---TSGAREKRRARRKVTRLVLVVVAVFVVCWL 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958642650 281 PNHILYLYRSFNykEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd14970   230 PFHVFQIVRLLI--DPPETLTVVGVFLFCIALSYANSCLNPILYAFLDENFRKSF 282
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
45-335 2.03e-41

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 146.98  E-value: 2.03e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASrYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd14984     2 FLPVLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLT-LPFWAV-YAADGWVFGSFLCKLVSALYT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNssftaCIP-YPQ 203
Cdd:cd14984    80 INFYSGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSQVSEENGSSI-----CSYdYPE 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELHPKI-HSVLIFLVYFLIPLVIISIYYYHIAKTLIRSahnlpgeynehtkkQMETRKRLAKIVLVFVGCFVFCWFPN 282
Cdd:cd14984   155 DTATTWKTlLRLLQNILGFLLPLLVMLFCYSRIIRTLLRA--------------RNHKKHRALRVIFAVVVVFFLCWLPY 220
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958642650 283 HILYLYRSFN-YKEIDPSLGHM----IVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd14984   221 NIVLLLDTLQlLGIISRSCELSksldYALQVTESLAFSHCCLNPVLYAFVGVKFRKYL 278
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
46-334 3.93e-41

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 146.43  E-value: 3.93e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIPAIQLT 125
Cdd:cd14999     2 IGTVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLYLLT-IPFYVSTYFLKKWYFGDVGCRLLFSLDFL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 126 SVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLwTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACIPYPQtd 205
Cdd:cd14999    81 TMHASIFTLTVMSTERYLAVVKPLDTVKRSKSY-RKLLAGVIWLLSLLLTLPMAIMIRLVTVEDKSGGSKRICLPTWS-- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 206 ELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLpgeynEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNHIL 285
Cdd:cd14999   158 EESYKVYLTLLFSTSIVIPGLVIGYLYIRLARKYWLSQAAA-----SNSSRKRLPKQKVLKMIFTIVLVFWACFLPFWIW 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1958642650 286 YLYRSFNYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKH 334
Cdd:cd14999   233 QLLYLYSPSLSLSPRTTTYVNYLLTCLTYSNSCINPFLYTLLTKNYKEY 281
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
45-335 1.21e-39

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 142.50  E-value: 1.21e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDA-SRYFFDEWVFGKLGCKLIPAIQ 123
Cdd:cd15392     2 IIILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFiALLILQYWPFGEFMCPVVNYLQ 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGvvLWTSLKAVGIWVVSVLLAVPEAVFSEVarigssDNSSFTACIPYPQ 203
Cdd:cd15392    82 AVSVFVSAFTLVAISIDRYVAIMWPLRPRMTK--RQALLLIAVIWIFALATALPIAITSRL------FEDSNASCGQYIC 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDEL----HPKIHSVLIFLVYFLIPLVIISIYYYHIAktLIRSAHNLPGEYNEHTKKQM-ETRKRLAKIVLVFVGCFVFC 278
Cdd:cd15392   154 TESWpsdtNRYIYSLVLMILQYFVPLAVLVFTYTRIG--IVVWAKRTPGEAENNRDQRMaESKRKLVKMMITVVAIFALC 231
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 279 WFPNHILYLyrsfnYKEIDPSLGH----MIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15392   232 WLPLNILNL-----VGDHDESIYSwpyiPYLWLAAHWLAMSHCCYNPFIYCWMNAKFRNGF 287
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
45-334 3.76e-36

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 132.96  E-value: 3.76e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDE-WVFGKLGCKLIPAIQ 123
Cdd:cd15088     2 IMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLG-MPFLIHQFAIDGqWYFGEVMCKIITALD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVarIGSSDNSSFTAcIPYPQ 203
Cdd:cd15088    81 ANNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSL--IYFPDGTTFCY-VSLPS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELHpkIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHnlPGEYNEHTKKQmetrKRLAKIVLVFVGCFVFCWFPNH 283
Cdd:cd15088   158 PDDLY--WFTIYHFILGFAVPLVVITVCYILILHRLARGVA--PGNQSHGSSRT----KRVTKMVILIVVVFIVCWLPFH 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 284 ILYLyrsFNYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKH 334
Cdd:cd15088   230 VVQL---VNLAMNRPTLAFEVAYFLSICLGYANSCLNPFVYILVSENFRKR 277
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
45-335 2.25e-35

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 130.99  E-value: 2.25e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTmRSVP---NIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPA 121
Cdd:cd15002     1 LVPILLGVICLLGFAGNLMVIGILLNNAR-KGKPsliDSLILNLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTADW 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 122 IQLTSVGVSVFTLTALSADRYRAIVNPMDMQTsgvVLWTSLKAV--GIWVVSVLLAVPEAVFSEVARigSSDNSSFTACI 199
Cdd:cd15002    80 FGHACMAAKSFTIAVLAKACYMYVVNPTKQVT---IKQRRITAVvaSIWVPACLLPLPQWLFRTVKQ--SEGVYLCILCI 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 200 PYP-QTDELhpkIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAhnlpgeynehTKKQMET----RKRLAKIVLVFVGC 274
Cdd:cd15002   155 PPLaHEFMS---AFVKLYPLFVFCLPLTFALFYFWRAYGQCQRRG----------TKTQNLRnqirSRKLTHMLLSVVLA 221
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 275 FVFCWFPNHILYLYrSFNYKEIDPSlGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15002   222 FTILWLPEWVAWLW-LIHIKSSGSS-PPQLFNVLAQLLAFSISSVNPIIFLLMSEEFREGF 280
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
49-335 1.17e-34

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 129.05  E-value: 1.17e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd15206     6 LYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQAVSVS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPMDMQTsgvvlWTSLK-----AVGIWVVSVLLAVPEAVFSEVARIgssDNSSFTACIPYpQ 203
Cdd:cd15206    86 VSTFTLVAISLERYFAICHPLKSRV-----WQTLShaykvIAGIWLLSFLIMSPILVFSNLIPM---SRPGGHKCREV-W 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIrsahnlpgeynehtkkqmETRKRLAKIVLVFVGCFVFCWFPNH 283
Cdd:cd15206   157 PNEIAEQAWYVFLDLMLLVIPGLVMSVAYGLISWTLL------------------EAKKRVIRMLFVIVVEFFICWTPLY 218
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958642650 284 ILYLYRSFNYKEIDPSLGHMIVTLVaRVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15206   219 VINTWKAFDPPSAARYVSSTTISLI-QLLAYISSCVNPITYCFMNKRFRQAF 269
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
50-335 3.62e-34

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 128.22  E-value: 3.62e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  50 YLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYF-FDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd15134     7 YGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWqQYPWVFGEVFCKLRAFLSEMSSY 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPMDMQTSGvVLWTSLKAV-GIWVVSVLLAVPEAVFSEVARIGSSDNSSFT-----ACIPYP 202
Cdd:cd15134    87 ASVLTITAFSVERYLAICHPLRSHTMS-KLSRAIRIIiAIWIIAFVCALPFAIQTRIVYLEYPPTSGEAleesaFCAMLN 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 203 QTDELHPKIHsvLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEH-TKKQMETRKRLAKIVLVFVGCFVFCWFP 281
Cdd:cd15134   166 EIPPITPVFQ--LSTFLFFIIPMIAIIVLYVLIGLQLRRSTLLRRGQRSVSgGRRSSQSRRTVLRMLVAVVVAFFICWAP 243
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958642650 282 NHILYLYRSFNYKEIDPSL-GHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15134   244 FHAQRLLTVYAKNMTPPYLfINRILFYISGVLYYVSSTVNPILYNVMSAKYRQAF 298
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
49-335 3.75e-34

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 128.36  E-value: 3.75e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd15205     6 TYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQSTAVV 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPMDMQtsgvVLWTSLKAVGI----WVVSVLLAVPEAVFSEVARIGSSDNSSFTACIPYPQT 204
Cdd:cd15205    86 TSILTMTCIAVERHQGIVHPLKMK----WQYTNRRAFTMlglvWIVSVIVGSPMLFVQQLEVKYDFLYEKRHVCCLERWY 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTL-----IRSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFVFCW 279
Cdd:cd15205   162 SPTQQKIYTTFILVILFLLPLTTMLFLYSRIGYELwikkrVGDASVLQTIHGIEMSKISRKKKRAVKMMVTVVLLFAVCW 241
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958642650 280 FPNHILYLYR--SFNYKEIDPSLGHMIVTLVaRVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15205   242 APFHVVHMMIeySNLENKYDGVTIKLIFAIV-QLIGFSNSFNNPIVYAFMNENFKKNF 298
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
45-335 5.68e-34

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 127.19  E-value: 5.68e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15093     2 LIPCIYAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELFMLG-LPFLAASNALRHWPFGSVLCRLVLSVDG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVArigsSDNSSFTAC-IPYPQ 203
Cdd:cd15093    81 INMFTSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVVFAGTR----ENQDGSSACnMQWPE 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTlIRSAHNLPGeynehTKKQMETRKRLAKIVLVFVGCFVFCWFPNH 283
Cdd:cd15093   157 PAAAWSAGFIIYTFVLGFLLPLLIICLCYLLIVIK-VKSAGLRAG-----WQQRKRSERKVTRMVVMVVVVFVICWLPFY 230
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958642650 284 ILYLYRSFNYKEIDPSLGHMIVTLVarVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15093   231 VLQLVNVFVQLPETPALVGVYHFVV--ILSYANSCANPILYGFLSDNFKKSF 280
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
50-335 6.09e-34

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 127.35  E-value: 6.09e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  50 YLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGV 129
Cdd:cd16003     7 YGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPITSVFA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 130 SVFTLTALSADRYRAIVNPMDMQTSGVVlwTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSdnssfTAC-IPYPQTDELH 208
Cdd:cd16003    87 SIYSMTAIAVDRYMAIIDPLKPRLSATA--TKVVIGSIWILAFLLAFPQCLYSKTKVMPGR-----TLCfVAWPGGPDQH 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 209 PKIHSVLIFLVYfLIPLVIISIYYYHIAKTLIrsAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNHILYLY 288
Cdd:cd16003   160 FTYHIIVIVLVY-CLPLLVMGITYTIVGITLW--GGEIPGDTSDKYHEQLRAKRKVVKMMIIVVLTFAICWLPYHIYFIV 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1958642650 289 RSFnYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd16003   237 TGL-YQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGF 282
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
49-333 6.74e-34

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 127.18  E-value: 6.74e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd15012     5 LYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSYT 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPMDMQ--TSGVVLWTSLkaVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTA--CIPYPQT 204
Cdd:cd15012    85 ASIGILVVISVERYIAILHPLRCKqlLTAARLRVTI--VTVWLTSAVYNTPYFVFSQTVEILVTQDGQEEEicVLDREMF 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DElhpKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPgeynehtkkqmetRKRLAKIVLVFVGCFVFCWFPNHI 284
Cdd:cd15012   163 NS---KLYDTINFIVWYLIPLLIMTVLYSKISIVLWKSSSIEA-------------RRKVVRLLVAVVVSFALCNLPYHA 226
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1958642650 285 LYLYRSFNYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15012   227 RKMWQYWSEPYRCDSNWNALLTPLTFLVLYFNSAVNPLLYAFLSKRFRQ 275
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
45-335 1.03e-33

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 126.60  E-value: 1.03e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15089     2 AITALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATST-LPFQSAKYLMETWPFGELLCKAVLSIDY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVfseVARIGSSDNSSFTACIPYPQT 204
Cdd:cd15089    81 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMV---MAVTKTPRDGAVVCMLQFPSP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLiRSAHNLPGeynehTKKQMETRKRLAKIVLVFVGCFVFCWFPNHI 284
Cdd:cd15089   158 SWYWDTVTKICVFIFAFVVPILVITVCYGLMILRL-RSVRLLSG-----SKEKDRNLRRITRMVLVVVAAFIICWTPIHI 231
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958642650 285 LYLYRSFnyKEIDPSLGHMIVTL-VARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15089   232 FVIVWTL--VDIDRRNPLVVAALhLCIALGYANSSLNPVLYAFLDENFKRCF 281
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
49-335 2.12e-33

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 125.37  E-value: 2.12e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd14967     5 FLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCCT 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPM---DMQTSGVVLWTSlkaVGIWVVSVLLAVPeAVFSEvaRIGSSDNSSFTACIPYPQtd 205
Cdd:cd14967    85 ASILNLCAISLDRYLAITRPLryrQLMTKKRALIMI---AAVWVYSLLISLP-PLVGW--RDETQPSVVDCECEFTPN-- 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 206 elhpKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSahnlpgeynehtkkqmetrKRLAKIVLVFVGCFVFCWFPNHIL 285
Cdd:cd14967   157 ----KIYVLVSSVISFFIPLLIMIVLYARIFRVARRE-------------------LKAAKTLAIIVGAFLLCWLPFFII 213
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958642650 286 YLYRSFNYKEIDPSLGHMIVTLvarvLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd14967   214 YLVSAFCPPDCVPPILYAVFFW----LGYLNSALNPIIYALFNRDFRRAF 259
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
46-335 1.75e-32

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 123.44  E-value: 1.75e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIPAIQLT 125
Cdd:cd15092     3 IVVVYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLT-LPFQGTDIFLGFWPFGNALCKTVIAIDYY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 126 SVGVSVFTLTALSADRYRAIVNP---MDMQTSGVvlwTSLKAVGIWVVSVLLAVPEAVFSEVarigSSDNSSFTACIPYP 202
Cdd:cd15092    82 NMFTSTFTLTAMSVDRYVAICHPikaLDVRTPHK---AKVVNVCIWALASVVGVPVMVMGSA----QVEDEEIECLVEIP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 203 QTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLiRSAHNLPGeynehTKKQMETRKRLAKIVLVFVGCFVFCWFPN 282
Cdd:cd15092   155 TPQDYWDPVFGICVFLFSFIIPVLIISVCYSLMIRRL-RGVRLLSG-----SKEKDRNLRRITRLVLVVVAVFVGCWTPI 228
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 283 HILYLYRSFNYKEidPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15092   229 QIFVLAQGLGVQP--SSETAVAILRFCTALGYVNSSLNPVLYAFLDENFKACF 279
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
50-335 1.85e-32

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 123.39  E-value: 1.85e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  50 YLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGV 129
Cdd:cd15399     7 YCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQALAVHV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 130 SVFTLTALSADRYRAIVNPMDMQTSGVvlwTSLKAVGI-WVVSVLLAVPEAVFSEVARIGSSDNSSFTACIP-YPQTDEL 207
Cdd:cd15399    87 STVTLTVIALDRHRCIVYHLESKISKK---ISFLIIGLtWAASALLASPLAIFREYSVIEISPDFKIQACSEkWPNGTLN 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 208 HPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLirSAHNLPGEYNEHTKKQmetRKRLAKIVLVFVGCFVFCWFPNHILYL 287
Cdd:cd15399   164 DGTIYSVSMLLIQYVLPLAIISYAYIRIWTKL--KNHVSPGGGNDHYHQR---RRKTTKMLVCVVVVFAVSWLPFHAFQL 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1958642650 288 YRSFNYKEIDPSLGHMIVTLVaRVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15399   239 ASDIDSKVLDLKEYKLIYTIF-HVIAMCSTFANPLLYGWMNNNYRTAF 285
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
49-335 1.99e-32

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 123.55  E-value: 1.99e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDE-WVFGKLGCKLIPAIQLTSV 127
Cdd:cd14997     6 VYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWAREpWLLGEFMCKLVPFVELTVA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACIpyPQTDEL 207
Cdd:cd14997    86 HASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFITEFKEEDFNDGTPVAVCR--TPADTF 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 208 HPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNHILYL 287
Cdd:cd14997   164 WKVAYILSTIVVFFVVPLAILSGLYSVICRRLVGHPALESRRADAANRHTLRSRRQVVYMLITVVVLFFVCLLPFRVVTL 243
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 288 YRSFNYKEIDPSLG---HMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd14997   244 WIIFAPDEDLQALGlegYLNLLVFCRVMVYLNSALNPILYNLMSTKFRSAF 294
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
45-333 3.09e-32

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 123.33  E-value: 3.09e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGN-IMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFD-EWVFGKLGCKLIPAI 122
Cdd:cd15190    12 LIPVIYMLVFVLGLSGNgLVLWTVFRSKRKRRRSADTFIANLALADLTFVVT-LPLWAVYTALGyHWPFGSFLCKLSSYL 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 123 QLTSVGVSVFTLTALSADRYRAIVNPMdmqTSGVVLW--TSLKAVG-IWVVSVLLAVPEAVFSEVARIgssDNSSFTAC- 198
Cdd:cd15190    91 VFVNMYASVFCLTGLSFDRYLAIVRSL---ASAKLRSrtSGIVALGvIWLLAALLALPALILRTTSDL---EGTNKVICd 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 199 -----IPYPQTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNlpgeyneHTKKQMETRKRLAKIVLVFVG 273
Cdd:cd15190   165 mdysgVVSNESEWAWIAGLGLSSTVLGFLLPFLIMLTCYFFIGRTVARHFSK-------LRRKEDKKKRRLLKIIITLVV 237
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958642650 274 CFVFCWFPNHILYLYRSFNYKEIDP---SLGHMIVTL--VARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15190   238 TFALCWLPFHLVKTLYALMYLGILPfscGFDLFLMNAhpYATCLAYVNSCLNPFLYAFFDPRFRQ 302
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
45-333 4.35e-32

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 122.23  E-value: 4.35e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNImLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFD-EWVFGKLGCKLIPAIQ 123
Cdd:cd15339     2 ILPSFIGILCSTGLVGNI-LVLFTIIRSRKKTVPDIYVCNLAVADLVHIIV-MPFLIHQWARGgEWVFGSPLCTIITSLD 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVarIGSSDNSSFTAcipypq 203
Cdd:cd15339    80 TCNQFACSAIMTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWVYAKV--IKFRDGLESCA------ 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELHPKihSVLIFLVY-----FLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFVFC 278
Cdd:cd15339   152 FNLTSPD--DVLWYTLYqtittFFFPLPLILICYILILCYTWEMYRKNKKAGRYNTSIPRQRVMRLTKMVLVLVGVFLVS 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958642650 279 WFPNHILYLyrsFNYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15339   230 AAPYHVIQL---VNLSVSQPTLAFYVSYYLSICLSYASSSINPFLYILLSGNFRK 281
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
46-335 9.27e-32

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 121.31  E-value: 9.27e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLtCVPVDASrYFFDEWVFGKLGCKLIPAIQLT 125
Cdd:cd15182     3 LPVFYYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTF-TLPFWAS-YHSSGWIFGEILCKAVTSIFYI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 126 SVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVaRIGSSDNSsftacipYPQTD 205
Cdd:cd15182    81 GFYSSILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPELILSTV-MKSDEDGS-------LCEYS 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 206 ELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSahnlpgeynehtkkQMETRKRLAKIVLVFVGCFVFCWFPNHIL 285
Cdd:cd15182   153 SIKWKLGYYYQQNLFFLIPLGIIVYCYVRILQTLMRT--------------RTMRKHRTVKLIFVIVLVFFLSWAPYNIV 218
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 286 YLYRSFNYKEI---DPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15182   219 IFLRSLKDLTIpicECSKQLDYAFYICRNIAFSHCCLNPVFYVFVGVKFRNHL 271
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
46-335 2.35e-31

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 120.61  E-value: 2.35e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLT 125
Cdd:cd15192     3 IPTVYSIIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLWAAYTAMEYHWPFGNFLCKIASALVSF 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 126 SVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIgssDNSSFTAC-IPYPQT 204
Cdd:cd15192    83 NLYASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAIIHRDVFFI---ENTNITVCaFHYPSQ 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSahnlpgeynEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNHI 284
Cdd:cd15192   160 NSTLLVGLGLMKNLLGFLIPFLIILTCYTLIGKALKKA---------YEIQRNKPRNDEIFKMIMAVVLFFFFCWIPHQI 230
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958642650 285 LYLYRSFNYKEI--DPSLGHMIVTLVARV--LSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15192   231 FTFLDVLIQLKViqDCHIADIVDTAMPFTicIAYFNSCLNPILYGFVGKNFRKKF 285
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
45-335 2.67e-31

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 120.24  E-value: 2.67e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFD-EWVFGKLGCKLIPAIQ 123
Cdd:cd15191     2 AIPVLYSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLAT-LPLWATYYSYGyNWLFGSVMCKICGSLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSgvVLW-TSLKAVGIWVVSVLLAVPEAVFSEVARIgssDNSSFTACI-PY 201
Cdd:cd15191    81 TLNLFASIFFITCMSVDRYLAVVYPLRSQRR--RSWqARLVCLLVWVLACLSSLPTFYFRDTYYI---EELGVNACImAF 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 202 PQTDELHPKIHSVLI-FLVYFLIPLVIISIYYYHIAKTLIRSahnlpgeynEHTKKQMETRKRLAKIVLVFVGCFVFCWF 280
Cdd:cd15191   156 PNEKYAQWSAGLALMkNTLGFLIPLIVIATCYFGIGRHLLKT---------KGFGKNKQRRDKVLKMVAAVVLAFLICWF 226
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 281 PNHILYLYRSFNYKEIDPSLghMIVTLVARVLS------FSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15191   227 PFHVLTFLDALARMGVINNC--WVITVIDKALPfaiclgFSNSCINPFLYCFVGNHFREKL 285
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
49-335 4.84e-31

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 119.33  E-value: 4.84e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLvkIFLTNSTM-RSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDE-WVFGKLGCKLIPAIQLTS 126
Cdd:cd14974     6 LYALIFLLGLPGNGLV--IWVAGFKMkRTVNTVWFLNLALADFLFCLF-LPFLIVYIAMGHhWPFGSVLCKLNSFVISLN 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 127 VGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVArigsSDNSSFTACIPYPQTDE 206
Cdd:cd14974    83 MFASVFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSVPYFVFRDTV----THHNGRSCNLTCVEDYD 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 207 LHPKIHSVLI---FLVYFLIPLVIISIYYYHIAKTLIRsahnlpgeynehtkKQMETRKRLAKIVLVFVGCFVFCWFPNH 283
Cdd:cd14974   159 LRRSRHKALTvirFLCGFLLPLLIIAICYSVIAVKLRR--------------KRLAKSSKPLRVLLAVVVAFFLCWLPYH 224
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 284 ILYLYRSFNYKEIDPSLghMIVTLVARVLSFSNSCVNPFaLYLL-SESFRKHF 335
Cdd:cd14974   225 VFALLELVAAAGLPEVV--LLGLPLATGLAYFNSCLNPI-LYVFmGQDFRKRL 274
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
45-335 8.23e-31

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 118.86  E-value: 8.23e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15970     2 LISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLS-VPFLVTSTLLRHWPFGSLLCRLVLSVDA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVArigSSDNSSFTACIPYPQT 204
Cdd:cd15970    81 INMFTSIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPIIIFSNTA---PNSDGSVACNMQMPEP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAhnLPGEYNEHTKKQmetrKRLAKIVLVFVGCFVFCWFPNHI 284
Cdd:cd15970   158 SQRWLAVFVVYTFLMGFLLPVIAICLCYILIIVKMRVVA--LKAGWQQRKRSE----RKITLMVMMVVTVFVICWMPFYV 231
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 285 LYLYRSFNYKeidpslGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15970   232 VQLVSVFVGQ------HDATVSQLSVILGYANSCANPILYGFLSDNFKRSF 276
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
45-335 8.60e-31

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 118.77  E-value: 8.60e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTM-RSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQ 123
Cdd:cd15097     2 IVPVVFSLIFLLGTVGNSLVLAVLLRSGQSgHNTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFFI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPM---DMQTSgvvlWTSLKAVG-IWVVSVLLAVPEAVFSEVARIGSSdnssfTACI 199
Cdd:cd15097    82 YLTMYASSFTLAAVSVDRYLAIRYPLrsrELRTP----RNAVAAIAlIWGLSLLFAGPYLSYYDLIDYANS-----TVCM 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 200 pyPQTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHnlPGEYNEHTKKqmeTRKRLAKIVLVFVGCFVFCW 279
Cdd:cd15097   153 --PGWEEARRKAMDTCTFAFGYLIPVLVVSLSYTRTIKYLWTAVD--PLEAMSESKR---AKRKVTKMIIIVTALFCLCW 225
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958642650 280 FPNHIL---YLYRSFNYKEIDPSLghmivTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15097   226 LPHHVVilcYLYGDFPFNQATYAF-----RLLSHCMAYANSCLNPIVYALVSKHFRKGF 279
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
45-335 8.90e-31

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 118.92  E-value: 8.90e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDE--WVFGKLGCKLIPAI 122
Cdd:cd15204     2 VLGVVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEMDYYVVRQrsWTHGDVLCAVVNYL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 123 QLTSVGVSVFTLTALSADRYRAIVNP----MDMQTSGVVLwtslkaVGIWVVSVLLAVPEAVFSEVArIGSSDNSSFTAC 198
Cdd:cd15204    82 RTVSLYVSTNALLVIAIDRYLVIVHPlkprMKRRTACVVI------ALVWVVSLLLAIPSAVYSKTT-PYANQGKIFCGQ 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 199 IpYPQTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRsaHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFVFC 278
Cdd:cd15204   155 I-WPVDQQAYYKAYYLFLFVLEFVLPVLIMTLCYLRIVRKVWF--RRVPGQQTEQIRRRLRRRRRKVRLLVVILTAFVLC 231
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642650 279 WFPNHILYLYRSFNYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15204   232 WAPYYGYAIVRDFFPTLLSKEKLNTTIFYIVEALAMSNSMINTVVYVAFNNNIRKYL 288
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
50-335 1.84e-30

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 118.45  E-value: 1.84e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  50 YLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGV 129
Cdd:cd15980     7 YLLIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQGISVSA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 130 SVFTLTALSADRYRAIVNP----MDMQTSGVVLwtslkaVGIWVVSVLLAVPEAVFSEV-------ARIGSSDNSS-FTA 197
Cdd:cd15980    87 SVFTLVAIAVDRFRCIVYPfkqkLTISTAVVII------VIIWVLAIAIMCPSAVMLHVqeeknyrVVLGSQNKTSpVYW 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 198 CIPYPQTDELHpKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTKKQMETRK-RLAKIVLVFVGCFV 276
Cdd:cd15980   161 CREDWPNQEMR-KIYTTVLFANIYLAPLSLIVIMYARIGITLFKTAMPHTGKHNQEQRHVVSRKKqKVIKMLLIVALLFI 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 277 FCWFPNHILYLYRSF-NYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15980   240 LSWLPLWTLMMLSDYaNLSPNQLQIINIYIYPFAHWLAFFNSSVNPIIYGFFNENFRRGF 299
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
45-335 1.85e-30

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 117.79  E-value: 1.85e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15090     2 TIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGNILCKIVISIDY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVarigSSDNSSFTACIPYPQT 204
Cdd:cd15090    81 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATT----KYRQGSIDCTLTFSHP 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLiRSAHNLPGeynehTKKQMETRKRLAKIVLVFVGCFVFCWFPNHI 284
Cdd:cd15090   157 SWYWENLLKICVFIFAFIMPVLIITVCYGLMILRL-KSVRMLSG-----SKEKDRNLRRITRMVLVVVAVFIVCWTPIHI 230
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 285 LYLYRSFnyKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15090   231 YVIIKAL--VTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 279
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
49-335 2.06e-30

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 118.23  E-value: 2.06e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFF-DEWVFGKLGCKLIPAIQLTSV 127
Cdd:cd14979     6 IYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWqYPWAFGDGGCKLYYFLFEACT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNS---SFTACIPYPQT 204
Cdd:cd14979    86 YATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLMGIQYLNGPLPGpvpDSAVCTLVVDR 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHPKIHSVliFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTKK-----QMETRKRLAKIVLVFVGCFVFCW 279
Cdd:cd14979   166 STFKYVFQVS--TFIFFVLPMFVISILYFRIGVKLRSMRNIKKGTRAQGTRNvelslSQQARRQVVKMLGAVVIAFFVCW 243
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642650 280 FPNHILYLYRSFNYKEIDP-SLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd14979   244 LPFHAQRLMFSYASKEDTFlFDFYQYLYPISGILFYLSSAINPILYNLMSSRFRVAF 300
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
45-335 2.21e-29

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 114.95  E-value: 2.21e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15973     2 VIQFIYALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLS-VPFLAASAALQHWPFGSAMCRTVLSVDG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVArigSSDNSSFTACIPYPqt 204
Cdd:cd15973    81 INMFTSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTA---TRKGQAVACNLIWP-- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 delHPKIHSVLI---FLVYFLIPLVIISIYYYHIAKTLirSAHNLPGEYNEHTKKQmetrKRLAKIVLVFVGCFVFCWFP 281
Cdd:cd15973   156 ---HPAWSAAFViytFLLGFLLPVLAIGLCYILIIGKM--RAVALKAGWQQRRKSE----KKITRMVLMVVTVFVICWMP 226
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 282 NHILYLYRSFnykeidpsLGHMIVTL--VARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15973   227 FYVVQLLNLF--------LPRLDATVnhASLILSYANSCANPILYGFLSDNFRRSF 274
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
45-333 2.31e-29

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 114.87  E-value: 2.31e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDA---SRYFfdEWVFGKLGCKLIPA 121
Cdd:cd15189     2 IIPPFIFSLCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADLVFVSG-LPFWAmniLNQF--NWPFGELLCRVVNG 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 122 IQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIgSSDNSsfTACI-P 200
Cdd:cd15189    79 VIKVNLYTSIYLLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPTFLLRKIKAI-PDLNI--TACVlL 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 201 YPQtdELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSahnlpgeyNEHTKKQMETRKRLAKIVLVFVGCFVFCWF 280
Cdd:cd15189   156 YPH--EAWHFAHIVLLNIVGFLLPLLVITFCNYNILQALRTR--------EESTRCEDRNDSKATALVLAVTLLFLVCWG 225
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642650 281 PNHIL-YLYRSFNYKEIDPSLGHMIVTLVARV---LSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15189   226 PYHFFtFLDFLFDVGVLDECFWEHFIDIGLQLavfLAFSNSCLNPVLYVFVGRYFRR 282
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
50-333 3.91e-29

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 114.45  E-value: 3.91e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  50 YLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGV 129
Cdd:cd15397     7 YSLVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILVCLVCLPFTVVYTLMDYWIFGEVLCKMTPFIQCMSVTV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 130 SVFTLTALSADRYRAIVNPMDMQTSgvvLWTSLKAVG-IWVVSVLLAVPEAVFSEVARIGSSDNSSFTA-------CIPY 201
Cdd:cd15397    87 SILSLVLIALERHQLIINPTGWKPS---VSQAYLAVVvIWMLACFISLPFLAFHILTDEPYKNLSHFFApladkavCTES 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 202 PQTDElHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLP--GEYNehtkKQMETRKRLAKIVLVFVGCFVFCW 279
Cdd:cd15397   164 WPSEH-HKLAYTTWLLLFQYCLPLLFILVCYLRIYLRLRRRKDMLErrGEYN----RRAGHSKRINVMLVSLVAAFALCW 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958642650 280 FPNHILYLYRSFNYKEIDPSLGHMIVTLvARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15397   239 LPLNVFNAIADWNHEAIPHCQHNLIFSL-CHLAAMASTCVNPIIYGFLNSNFKK 291
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
50-335 5.46e-29

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 114.17  E-value: 5.46e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  50 YLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGV 129
Cdd:cd16004     7 YSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPITAMFV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 130 SVFTLTALSADRYRAIVNPMDMQTSGvvlwTSLKAV--GIWVVSVLLAVPEAVFSEVarigSSDNSSfTACI---PYPQT 204
Cdd:cd16004    87 SIYSMTAIAADRYMAIIHPFKPRLSA----GSTKVViaGIWLVALALAFPQCFYSTV----TMDQGR-TKCIvawPGDSG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHPKIHSVLIFLVYFLiPLVIISIYYYHIAKTLIRSAhnLPGEYN-EHTKKQMETRKRLAKIVLVFVGCFVFCWFPNH 283
Cdd:cd16004   158 GKHQLTYHLAVIVLIYLL-PLAVMFVTYSIIGITLWRSA--VPGHQAhGAYHRQLQAKKKFVKTMVVVVVTFAICWLPYH 234
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958642650 284 ILYLYRSFNykeIDPSLGHMI--VTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd16004   235 LYFILGSFN---EDIYCQKYIqqVYLAIFWLAMSSTMYNPIIYCCLNQRFRSGF 285
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
46-335 7.94e-29

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 113.33  E-value: 7.94e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTC--VPVDASRyffdEWVFGKLGCKLIPAIQ 123
Cdd:cd15173     3 LPCMYSVMFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLFLCTLpfWAYSAAH----EWIFGTVMCKITNGLY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNP--MDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVArigssdNSSFTACIPY 201
Cdd:cd15173    79 TINLYSSMLILTCITVDRFIVIVQAtkAHNCHAKKMRWGKVVCTLVWVISLLLSLPQFIYSEVR------NLSSKICSMV 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 202 PQTDELHpKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSahnlpGEYNEHtkkqmetrkRLAKIVLVFVGCFVFCWFP 281
Cdd:cd15173   153 YPPDAIE-VVVNIIQMTVGFFLPLLAMIICYSVIIKTLLHA-----KGFQKH---------KSLKIIFVVVAVFILTQLP 217
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958642650 282 NHILYLYRSFnYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15173   218 YNIMKLIRTL-HIENTDSTNFKYAILITEAIAYLHACLNPILYAFVGVKFRKNF 270
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
45-335 7.99e-29

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 113.46  E-value: 7.99e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIpAIQL 124
Cdd:cd14969     2 VLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIY-GFAV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVG-VSVFTLTALSADRYRAIVNPMDMQTSGvvLWTSLKAV-GIWVVSVLLA----------VPEAVFSEVARIGSSDN 192
Cdd:cd14969    81 TFLGlVSISTLAALAFERYLVIVRPLKAFRLS--KRRALILIaFIWLYGLFWAlpplfgwssyVPEGGGTSCSVDWYSKD 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 193 SSFTACIpypqtdelhpkihsVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNL-PGEYNEHTKKQMETRKRLAKIVLVF 271
Cdd:cd14969   159 PNSLSYI--------------VSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAaRRKNSAITKRTKKAEKKVAKMVLVM 224
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958642650 272 VGCFVFCWFPNHILYLYRSFNYKEIDPSLGHMIVTLVARvlsfSNSCVNPFALYLLSESFRKHF 335
Cdd:cd14969   225 IVAFLIAWTPYAVVSLYVSFGGESTIPPLLATIPALFAK----SSTIYNPIIYVFMNKQFRRAL 284
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
45-335 9.79e-29

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 113.12  E-value: 9.79e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15091     2 IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTT-MPFQSTVYLMNSWPFGDVLCKIVISIDY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVfseVARIGSSDNSSFTAC-IPYPQ 203
Cdd:cd15091    81 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIV---LGGTKVREDVDSTECsLQFPD 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELH-PKIHSVLIFLVYFLIPLVIISIYYYHIAKTLiRSAHNLPGeynehTKKQMETRKRLAKIVLVFVGCFVFCWFPN 282
Cdd:cd15091   158 DDYSWwDTFMKICVFIFAFVIPVLIIIVCYTLMILRL-KSVRLLSG-----SREKDRNLRRITRLVLVVVAVFVVCWTPI 231
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 283 HILYLYRSFNykEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15091   232 HIFILVEALG--SVSHSTAAVSSYYFCIALGYTNSSLNPILYAFLDENFKRCF 282
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
49-335 1.04e-28

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 113.34  E-value: 1.04e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIpaIQLTSVG 128
Cdd:cd15094     6 LYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIG-LPFLIVTMILKYWPFGAAMCKIY--MVLTSIN 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 --VSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARigssDNSSFTACIPYPQTDE 206
Cdd:cd15094    83 qfTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTVP----DSGRYSCTIVWPDSSA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 207 LHP-KIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSahnlpGEYNEHTKKQMETRKrLAKIVLVFVGCFVFCWFPNHIL 285
Cdd:cd15094   159 VNGqKAFTLYTFLLGFAIPLLLISVFYTLVILRLRTV-----GPKNKSKEKRRSHRK-VTRLVLTVISVYIICWLPYWAF 232
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958642650 286 YLYRSFNYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15094   233 QVHLIFLPPGTDMPKWEILMFLLLTVLSYANSMVNPLLYAFLSENFRKSF 282
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
45-335 1.12e-28

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 113.37  E-value: 1.12e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVP--NIFISNLAAGDLLLLLTcVPVDASRYFFD-EWVFGKLGCKLIPA 121
Cdd:cd14976     2 LVSVVYMVVFTVGLLGNLLVLYLLKSNKKLRQQSesNKFVFNLALTDLIFVLT-LPFWAVEYALDfVWPFGTAMCKVVRY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 122 IQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVAriGSSDNSsfTAC-IP 200
Cdd:cd14976    81 VTKLNMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPEAIFSTDT--WSSVNH--TLClLR 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 201 YPQTDELHPK-----IHSVLIFLVYFLIPLVIISIYYYHIAKTLIRsahnlpgeyneHTKKQMETRKRLAKIVLVFVGCF 275
Cdd:cd14976   157 FPKNSSVTRWynwlgMYQLQKVVLGFFLPLGIITLSYLLLLRFLQR-----------KRGGSKRRKSRVTKSVFIVVLSF 225
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958642650 276 VFCWFPNHILYLYRSFNYKEIDP--SLGHMIVTL---VARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd14976   226 FICWLPNQALSLWSALIKFDDVPfsDAFFAFQTYafpVAICLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
45-335 2.45e-28

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 112.20  E-value: 2.45e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15972     2 LIPLVYLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELFMLG-LPFLAAQNALSYWPFGSFMCRLVMTVDA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSsdnssfTACIPYPQT 204
Cdd:cd15972    81 INQFTSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVIFSGVPGGMG------TCHIAWPEP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTKKQmetrKRLAKIVLVFVGCFVFCWFPNHI 284
Cdd:cd15972   155 AQVWRAGFIIYTATLGFFCPLLVICLCYLLIVVKVRSSGRRVRATSTKRRGSE----RKVTRMVVIVVAAFVLCWLPFYA 230
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 285 LYLYRSFNYKEIDPSLGHMIVTLVarVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15972   231 LNIVNLVCPLPEEPSLFGLYFFVV--VLSYANSCANPIIYGFLSDNFKQGF 279
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
49-335 2.05e-27

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 109.57  E-value: 2.05e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd15978     6 LYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPMDMQtsgvVLWTSLKAVGI----WVVSVLLAVPEAVFSEVARIGSSDNSSFTACIPYPQT 204
Cdd:cd15978    86 VSTFNLVAISLERYSAICKPLKSR----VWQTKSHALKViaatWCLSFTIMLPYPIYSNLVPFTRINNSTGNMCRLLWPN 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHPKIHsVLIFLVYFLIPLVIISIYYYHIAKTLIRSAhnlpgeynehtkKQMETRKRLAKIVLVFVGCFVFCWFPNHI 284
Cdd:cd15978   162 DVTQQSWY-IFLLLILFLIPGIVMMTAYGLISLELYRGI------------KFLMAKKRVIRMLIVIVILFFLCWTPIFS 228
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 285 LYLYRSFNYKEIDPSLGHMIVTLVaRVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15978   229 ANAWRAFDTRSADRLLSGAPISFI-HLLSYTSACVNPIIYCFMNKRFRMGF 278
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
49-335 2.29e-27

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 109.52  E-value: 2.29e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd15979     6 LYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSVS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACI---PYPQTD 205
Cdd:cd15979    86 VSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPVPVGDRPRGHQCRhawPSAQVR 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 206 ElhpkIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSahnlpgeynehtkkqMETRKRLAKIVLVFVGCFVFCWFPNHIL 285
Cdd:cd15979   166 Q----AWYVLLLLILFFIPGVVMIVAYGLISRELYRG---------------LLAKKRVIRMLVVIVAMFFLCWLPIFSA 226
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958642650 286 YLYRSFNYKEIDPSLGHMIVTLVaRVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15979   227 NTWRAFDPLSAHRALSGAPISFI-HLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
45-335 3.22e-27

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 109.28  E-value: 3.22e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDlLLLLTCVPVDASrYFF--DEWVFGKLGCKLIPAI 122
Cdd:cd14982     2 LFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALAD-LLFVLTLPFRIY-YYLngGWWPFGDFLCRLTGLL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 123 QLTSVGVSVFTLTALSADRYRAIVNPMDMqtsgVVLWTSLKAV----GIWVVSVLLAVPEAVFsevaRIGSSDNSSFTAC 198
Cdd:cd14982    80 FYINMYGSILFLTCISVDRYLAVVHPLKS----RRLRRKRYAVgvcaGVWILVLVASVPLLLL----RSTIAKENNSTTC 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 199 IPYPQTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAhnlpgeyNEHTKKQMetRKRLAKIVLVFVGCFVFC 278
Cdd:cd14982   152 FEFLSEWLASAAPIVLIALVVGFLIPLLIILVCYSLIIRALRRRS-------KQSQKSVR--KRKALRMILIVLAVFLVC 222
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 279 WFPNHI--LYLYRSFNYKEIDPSLGHMIVTL--VARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd14982   223 FLPYHVtrILYLLVRLSFIADCSARNSLYKAyrITLCLASLNSCLDPLIYYFLSKTFRKRL 283
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
46-335 3.23e-27

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 108.94  E-value: 3.23e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLT 125
Cdd:cd15168     3 LPIVYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSLPFLIYYYANGDHWIFGDFMCKLVRFLFYF 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 126 SVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSdnssfTACIPYPQTD 205
Cdd:cd15168    83 NLYGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFATTGRKNNR-----TTCYDTTSPE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 206 EL-HPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEynehtkkqmETRKRLAKIVLVFVGCFVFCWFPNHI 284
Cdd:cd15168   158 ELnDYVIYSMVLTGLGFLLPLLIILACYGLIVRALIRKLGEGVTS---------ALRRKSIRLVIIVLALFAVCFLPFHV 228
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 285 ---LYLYRSFNYKEIDPSLGHMI--VTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15168   229 trtINLAARLLSGTASCATLNGIyvAYKVTRPLASLNSCLNPLLYFLAGDKFRRRL 284
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
45-335 3.47e-27

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 109.06  E-value: 3.47e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15087     2 ALPVIYSVICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLV-LPINIAEHLLQQWPFGELLCKLILSIDH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNpmdMQTSGVVLWTSLKA-----VGIWVVSVLLAVPEAVFSEVarigSSDNSSFTAC- 198
Cdd:cd15087    81 YNIFSSIYFLTVMSVDRYLVVLA---TVRSRRMPYRTYRAakivsLCVWLLVTIIVLPFTVFAGV----YSNELGRKSCv 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 199 IPYPQTDELHPKIHSVLIFLVYFLIPLVIISIYYyhiaKTLIRSAHNLPGeyNEHTKKQMETRKRLAKIVLVFVGCFVFC 278
Cdd:cd15087   154 LSFPSPESLWFKASRIYTLVLGFAIPVSTICILY----TMMLYKLRNMRL--NSNAKALDKAKKKVTLMVLVVLAVCLFC 227
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 279 WFPNH---ILYLyrsfnYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15087   228 WTPFHlstVVAL-----TTDLPQTPLVIGISYFITSLSYANSCLNPFLYAFLDDSFRKSF 282
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
46-335 5.82e-27

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 108.38  E-value: 5.82e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIPAIQLT 125
Cdd:cd15185     3 LPPLYSLVFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLFT-LPFWIHYVRWNNWVFGHGMCKLLSGFYYL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 126 SVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEvarigSSDNSSFTACIP-YPQT 204
Cdd:cd15185    82 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAALPEFIFYE-----TQELFEEFLCSPlYPED 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHPK-IHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAhnlpgeynehTKKQMETRKRLAKIVLVFvgcFVFcWFPNH 283
Cdd:cd15185   157 TEDSWKrFHALRMNIFGLALPLLIMVICYTGIIKTLLRCP----------SKKKYKAIRLIFVIMVVF---FIF-WTPYN 222
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 284 ILYLYRSFNYKEIDPSLGHM----IVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15185   223 LVLLLSAFQSIFFETDCERSkhldLAMQVTEVIAYTHCCINPVIYAFVGERFRKYL 278
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
46-333 5.89e-27

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 108.30  E-value: 5.89e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLT 125
Cdd:cd15193     3 IPILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTALGGQWLFGEGLCKLSSFIIAV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 126 SVGVSVFTLTALSADRYRAIVNPMD---MQTSGVVLWTslkAVGIWVVSVLLAVPEAVF---SEVARIGSSDNSSFTACI 199
Cdd:cd15193    83 NRCSSILFLTGMSVDRYLAVVKLLDsrpLRTRRCALIT---CCIIWAVSLVLGIPSLVYrnlINESVCVEDSSSRFFQGI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 200 pypqtdelhpkihSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHnlpgeyneHTKKQMETRKRLAKIVLVFVGCFVFCW 279
Cdd:cd15193   160 -------------SLATLFLTFVLPLIVILFCYCSILVRLRRHFH--------GAKRTGRRRRNSLRIVFAIVTAFVLSW 218
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958642650 280 FP-NHILYLYRSFNYKEIDPSLGHMIVT----LVARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15193   219 LPfNTLKAVRLLLELGGGVLPCHTTVAIrqglTITACLAFVNSCVNPLIYSLLDRHFRR 277
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
52-334 6.18e-27

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 108.62  E-value: 6.18e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSV 131
Cdd:cd14986     9 VLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGEWVAGDVLCRIVKYLQVVGLFAST 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 132 FTLTALSADRYRAIVNPMDMQTSGvvlWTSLKAVGI-WVVSVLLAVPEA-VFSEVarigsSDNSSFTACIPYPQTdELHP 209
Cdd:cd14986    89 YILVSMSLDRYQAIVKPMSSLKPR---KRARLMIVVaWVLSFLFSIPQLvIFVER-----ELGDGVHQCWSSFYT-PWQR 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 210 KIHSVLIFLVYFLIPLVIISIYYYHIAKTL---IRSAHNLPGEYNEHTKKQ-----------METRKRLAKIVLVFVGCF 275
Cdd:cd14986   160 KVYITWLATYVFVIPLIILSYCYGRILRTIwirSRQKTDRPIAPTAMSCRSvscvssrvsliSRAKIKTIKMTLVIILAF 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958642650 276 VFCWFPNHILYLYRSFNYKEIDPSlghmIVTLVARVLSFSNSCVNPFaLYLLSESFRKH 334
Cdd:cd14986   240 ILCWTPYFIVQLLDVYAGMQQLEN----DAYVVSETLASLNSALNPL-IYGFFSSHLSF 293
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
50-333 6.31e-27

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 108.32  E-value: 6.31e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  50 YLIIISV-GLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLlTCVP---VDASRYFfdEWVFGKLGCKLIPAIQLT 125
Cdd:cd15381     6 YLWIIFVlGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLLV-CCLPfwaINISNGF--NWPFGEFLCKSVNAVIYM 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 126 SVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIgssDNSSFTACIPYPQTD 205
Cdd:cd15381    83 NLYSSIYFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMFGLLMSTPMIVFRTVMYF---PEYNITACVLDYPSE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 206 ELHPKIhSVLIFLVYFLIPLVIISIYYYHIAKTLirsahnlpgEYNEHTK-KQMETRKRLAKIVLVFVGCFVFCWFPNHI 284
Cdd:cd15381   160 GWHVAL-NILLNVVGFLIPLSIITFCSTQIIQVL---------RNNKMQKfKEIQTERKATVLVLAVLLMFFICWLPFHI 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 285 LYLYRSFNYKEIDPSLGHM----IVTLVARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15381   230 FTFLDTLHKLGLISGCRWEdildIGTQIATFLAYSNSCLNPLLYVIVGKHFRK 282
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
46-335 7.00e-27

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 108.24  E-value: 7.00e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVP---VDASRyffdEWVFGKLGCKLIPAI 122
Cdd:cd15180     3 LPVLYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVT-LPfwaVQAVH----GWIFGTGLCKLAGAV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 123 QLTSVGVSVFTLTALSADRYRAIVNPMDM---QTSGVVLWTSLKavgIWVVSVLLAVPEAVFSEVArigSSDNSSFTACI 199
Cdd:cd15180    78 FKINFYCGIFLLACISFDRYLSIVHAVQMysrKKPMLVHLSCLI---VWLFCLLLSIPDFIFLEAT---KDPRQNKTECV 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 200 P-YPQTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLpgeynehtKKQMETRkrlakIVLVFVGCFVFC 278
Cdd:cd15180   152 HnFPQSDTYWWLALRLLYHIVGFLLPLAVMVYCYTSILLRLLRSSQGF--------QKQRAIR-----VIVAVVVVFFLC 218
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958642650 279 WFPNHILYLYRSFNYKEIDPSLGHM-----IVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15180   219 WTPYNIALLVDTLIDLSVLDRNCGTesrldIALSVTSSLGYFHCCLNPLLYAFVGVKFRRKL 280
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
45-335 9.44e-27

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 107.62  E-value: 9.44e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15971     2 FLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELFMLG-LPFLAIQVALVHWPFGKAICRVVMTVDG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVarIGSSDNSSFTacIPYPQT 204
Cdd:cd15971    81 INQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIYAGV--QTKHGRSSCT--IIWPGE 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLpgeyneHTKKQMETRKRLAKIVLVFVGCFVFCWFPNHI 284
Cdd:cd15971   157 SSAWYTGFIIYTFILGFFVPLTIICLCYLFIIIKVKSSGIRV------GSSKRKKSEKKVTRMVSIVVAVFVFCWLPFYI 230
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 285 LYLYRSFNYKEIDPSLGHMIVTLVarVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15971   231 FNVSSVSVSISPTPGLKGMFDFVV--VLSYANSCANPILYAFLSDNFKKSF 279
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
50-335 1.57e-26

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 107.26  E-value: 1.57e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  50 YLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGV 129
Cdd:cd16002     7 YSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFPIAAVFA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 130 SVFTLTALSADRYRAIVNPMDMQTSGVVlwTSLKAVGIWVVSVLLAVPEAVFSEVARIgssdNSSFTACIPYPQTDEL-H 208
Cdd:cd16002    87 SIYSMTAIALDRYMAIIHPLQPRLSATA--TKVVICVIWVLAFLLAFPQGYYSDTEEM----PGRVVCYVEWPEHEERkY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 209 PKIHSVLIFLVYFLIPLVIISIYYYHIAKTLirSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNHILYLY 288
Cdd:cd16002   161 ETVYHVCVTVLIYFLPLLVIGCAYTVVGITL--WASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPYHIYFLL 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1958642650 289 RSFNYKEIDPSLGHMiVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd16002   239 QYFHPELYEQKFIQQ-VYLAIMWLAMSSTMYNPIIYCCLNDRFRVGF 284
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
49-334 2.09e-26

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 107.22  E-value: 2.09e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd15391     6 LYQSTIFLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPMDMQTSGVVlwTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACIPYPQTDELH 208
Cdd:cd15391    86 ASVLTNTAIGIDRFFAVIFPLRSRHTKSR--TKCIIASIWAISFSLSSVQLFAGRTQRYGQYSEGRVLCGESWPGPDTSR 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 209 PkIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRsaHNLPGEYNE-HTKKQMETRKRLAKIVLVFVGCFVFCWFPNHILYL 287
Cdd:cd15391   164 S-AYTVFVMLLTYIIPLLILTSTYGYVGFRLWN--RTAPGNADKgRDDMQIKSKRKVIKMLVFVVLMFGICWLPLHLFNL 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1958642650 288 YRSFNyKEIDPSLGHMIVTLVARV--LSFSNSCVNPFALYLLSESFRKH 334
Cdd:cd15391   241 VQDFS-TVFRNMPQHTTRLIYGAChwIAMSNSFVNPIIYLFMNDSFRSI 288
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
51-333 2.22e-26

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 106.20  E-value: 2.22e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  51 LIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVS 130
Cdd:cd15210     8 IVFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLVAVS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 131 VFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPeAVFSEVARIGSsdNSSFTACIPYPQTDELHPK 210
Cdd:cd15210    88 LLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLP-LWLGIWGRFGL--DPKVCSCSILRDKKGRSPK 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 211 IhsvLIFLVYFLIPLVIISIYYyhiaktlirsahnlpgeynehTKKQMetrKRLAKIVLVFVGCFVFCWFPNHILylyrs 290
Cdd:cd15210   165 T---FLFVFGFVLPCLVIIICY---------------------ARRED---RRLTRMMLVIFLCFLVCYLPITLV----- 212
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1958642650 291 fnyKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15210   213 ---NVFDDEVAPPVLHIIAYVLIWLSSCINPIIYVAMNRQYRQ 252
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
49-335 2.26e-26

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 106.32  E-value: 2.26e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLL-LLTCVP-VDASRYFFDEWVFGKLGCKLIPAIQLTS 126
Cdd:cd14995     6 LVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVlVAAGLPnEIESLLGPDSWIYGYAGCLLITYLQYLG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 127 VGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPeAVFSEVARIGSSDNSSFTACiPYPQTDE 206
Cdd:cd14995    86 INASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSP-WLFLLDLSIKHYGDDIVVRC-GYKVSRH 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 207 LHpKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSahnlpgeynehtkkqmetRKRLAKIVLVFVGCFVFCWFPNHILY 286
Cdd:cd14995   164 YY-LPIYLADFVLFYVIPLLLAIVLYGLIGRILFSS------------------RKQVTKMLAVVVVLFALLWMPYRTLV 224
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1958642650 287 LYRSFNykeiDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd14995   225 VYNSFA----SPPYLDLWFLLFCRTCIYLNSAINPILYNLMSQKFRAAF 269
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
49-328 2.83e-26

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 106.89  E-value: 2.83e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCvPVDASRYFFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd15079     6 IYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKM-PIFIYNSFYEGWALGPLGCQIYAFLGSLSGI 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPMDMQ--TSGvvlWTSLKAVGIWVVSVLLAVPEAVFSEvarigssdnSSF------TAC-I 199
Cdd:cd15079    85 GSIWTNAAIAYDRYNVIVKPLNGNplTRG---KALLLILFIWLYALPWALLPLLFGW---------GRYvpegflTSCsF 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 200 PYpQTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLpgeyNEHTKK-------------QMETRKRLAK 266
Cdd:cd15079   153 DY-LTRDWNTRSFVATIFVFAYVIPLIIIIYCYSFIVKAVFAHEKAL----REQAKKmnvvslrsnadanKQSAEIRIAK 227
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958642650 267 IVLVFVGCFVFCWFPNHILYLYRSFNYKEIDPSLGHMIVTLVARvlsfSNSCVNPFaLYLLS 328
Cdd:cd15079   228 VALTNVFLWFIAWTPYAVVALIGAFGNQSLLTPLVSMIPALFAK----TAACYNPI-VYAIS 284
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
46-332 4.58e-26

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 106.03  E-value: 4.58e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLtCVPVDASRYF-FDEWVFGKLGCKLIPAIQL 124
Cdd:cd15928     3 VTAVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFL-VLPLDLYRLWrYRPWRFGDLLCRLMYFFSE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACIPYPQT 204
Cdd:cd15928    82 TCTYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVLVGVEHIQGQQTPRGFECTVVNVS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELhpkiHSVLIFL--VYFLIPLVIISIYYYHIAKTLIRSAHNLPGeynEHTKKQMETRKRLAKIVLVFVGCFVFCWFPN 282
Cdd:cd15928   162 SGL----LSVMLWVstSFFFVPMVCLSLLYGLIGRALWDRRQRSRT---AGASRRDNNHRQTVRMLAVIVLAFVLCWLPF 234
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 283 HI-LYLYrsFNYKEIDPSLG--HMIVTLVARVLSFSNSCVNPFALYLLSESFR 332
Cdd:cd15928   235 HVgRVIF--NHSRASTKHLHyvSQYFNLVSFVLFYLSAAINPILYNLMSKRYR 285
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
45-335 5.27e-26

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 106.23  E-value: 5.27e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15048     2 VLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVDY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDnssftacipypQT 204
Cdd:cd15048    82 TLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLLYGPAIIGWDLWTGYSIV-----------PT 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHPKIHSVLIFL-----VYFLIPLVIIS-----IYYYHIAKTLIRSAHNLPGEYNEH------TKKQMETR---KRLA 265
Cdd:cd15048   151 GDCEVEFFDHFYFTfitsvLEFFIPFISVSffnllIYLNIRKRSRRRPLRSVPILPASQnpsrarSQREQVKLrrdRKAA 230
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 266 KIVLVFVGCFVFCWFPNHILYLYRSFnykeIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15048   231 KSLAILVLVFLICWAPYTILTIIRSF----CSGSCVDSYLYEFTFWLLWTNSAINPFLYAACHPRFRKAF 296
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
45-335 4.48e-25

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 102.96  E-value: 4.48e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15974     2 LIPVIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLG-LPFLATQNAISYWPFGSFLCRLVMTVDG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNssftacIPYPQT 204
Cdd:cd15974    81 VNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVIIFSDVQPDLNTCN------ISWPEP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHPKIHSVLIFLVYFLIPLVIISIYYYHIAkTLIRSAHNLPGeynehTKKQMETRKRLAKIVLVFVGCFVFCWFPNHI 284
Cdd:cd15974   155 VSVWSTAFIIYTAVLGFFGPLLVICLCYLLIV-IKVKSSGLRVG-----STKRRKSERKVTRMVVIIVVVFVFCWLPFYM 228
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 285 LYLYRSFNYKEIDPSLGHMIVTLVarVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15974   229 LNIVNLIVILPEEPAFVGVYFFVV--VLSYANSCANPILYGFLSDNFKQSF 277
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
45-281 4.58e-25

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 103.26  E-value: 4.58e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIpAIQL 124
Cdd:cd15336     2 TVGSVILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELY-AFCG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGV-SVFTLTALSADRYRAIVNPMDMqtsgvVLWTSLK-----AVGIWVVSVLLAVP-----EAVFSEVARIGSS-DN 192
Cdd:cd15336    81 ALFGItSMITLLAISLDRYLVITKPLAS-----IRWVSKKramiiILLVWLYSLAWSLPplfgwSAYVPEGLLTSCTwDY 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 193 SSFTACIpypqtdelhpKIHSVLIFLVYFLIPLVIISIYYYHIAKTlIRSA----HNLPGEYNEHTKKQMETRK---RLA 265
Cdd:cd15336   156 MTFTPSV----------RAYTMLLFCFVFFIPLGIIIYCYLFIFLA-IRSTgrevQKLGSQDRKEKAKQYQRMKnewKMA 224
                         250
                  ....*....|....*.
gi 1958642650 266 KIVLVFVGCFVFCWFP 281
Cdd:cd15336   225 KIAFVVILLFVLSWSP 240
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
50-335 6.23e-25

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 103.37  E-value: 6.23e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  50 YLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGV 129
Cdd:cd15981     7 YLFIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNAMCKMSGLVQGMSVSA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 130 SVFTLTALSADRYRAIVNPMDMQTSgvVLWTSLKAVGIWVVSVLLAVPEAVFSEVAR-----IGSSDNSS---FTACIPY 201
Cdd:cd15981    87 SVFTLVAIAVERFRCIVHPFRQKLT--LRKAIVTIVIIWVLALIIMCPSAVTLTVTReehhfMVDDYNNSyplYSCWEAW 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 202 PQTDelHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTKKQMETRKRLAKI-VLVFVGC-FVFCW 279
Cdd:cd15981   165 PDTE--MRKIYTTVLFSHIYLAPLTLIVIMYARIAFKLFKSSAPIRGSQGEEEEGRRVSKRKIKVInMLIIVALfFTLSW 242
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958642650 280 FPNHILYL---YRSFNYKEIDPSLGHmiVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15981   243 LPLWTLMLltdYGHLSEDQLNLVTVY--VFPFAHWLAFFNSSVNPIIYGYFNENFRRGF 299
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
46-334 7.17e-25

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 103.70  E-value: 7.17e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNImLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIPAIQLT 125
Cdd:PHA03087   43 LIVVYSTIFFFGLVGNI-IVIYVLTKTKIKTPMDIYLLNLAVSDLLFVMT-LPFQIYYYILFQWSFGEFACKIVSGLYYI 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 126 SVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVarigSSDNSSFTACIPYPQTD 205
Cdd:PHA03087  121 GFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTT----KKDHETLICCMFYNNKT 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 206 ELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNlpgeynehTKKqmetrKRLAKIVLVFVGCFVFCWFPNH-- 283
Cdd:PHA03087  197 MNWKLFINFEINIIGMLIPLTILLYCYSKILITLKGINKS--------KKN-----KKAIKLVLIIVILFVIFWLPFNvs 263
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 284 -ILYLYRSFNYKEIDPSLGHMIVTL-VARVLSFSNSCVNPFALYLLSESFRKH 334
Cdd:PHA03087  264 vFVYSLHILHFKSGCKAVKYIQYALhVTEIISLSHCCINPLIYAFVSEFFNKH 316
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
50-333 7.45e-25

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 102.97  E-value: 7.45e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  50 YLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGV 129
Cdd:cd15395     7 YSAVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMCLPFTFVYTLMDHWVFGEAMCKLNSMVQCISITV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 130 SVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAvgIWVVSVLLAVPEAVFS----EVARIGSSDNSSFT---ACIPYP 202
Cdd:cd15395    87 SIFSLVLIAIERHQLIINPRGWRPNNRHAYVGIAV--IWVLAVLTSLPFLIFQvltdEPFKNVNVSLDAYKgkyVCLDQF 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 203 QTDELHPKIHSVLIFLVYFlIPLVIISIYYYHIAKTLIRSaHNLPGEYNEHTKKQMETrKRLAKIVLVFVGCFVFCWFPN 282
Cdd:cd15395   165 PSDTIRLSYTTCLLVLQYF-GPLCFIFICYLKIYIRLKRR-NNMMDKMRDNKYRSSET-KRINIMLISIVVAFAVCWLPL 241
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 283 HILYLYRSFNYkEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15395   242 NIFNAVFDWNH-EAIATCNHNLLFLICHLTAMISTCVNPIFYGFLNKNFQR 291
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
49-333 3.46e-24

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 100.23  E-value: 3.46e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLvkIFLTNSTM-RSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSV 127
Cdd:cd15115     6 VLSLTFLLGVPGNGLV--IWVAGLKMkRTVNTIWFLNLAVADLLCCLSLPFSIAHLLLNGHWPYGRFLCKLLPSIIVLNM 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEvarigSSDNSSFTACIPYpqtdel 207
Cdd:cd15115    84 FASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLPVFIYRT-----TVTDGNHTRCGYD------ 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 208 HPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGeynehtkkqmetrKRLAKIVLVFVGCFVFCWFPNHILYL 287
Cdd:cd15115   153 FLVAITITRAVFGFLLPLLIIAACYSFIAFRMQRGRFAKSQ-------------SKTFRVIIAVVVAFFVCWAPYHIIGI 219
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1958642650 288 YRSFNykeiDPSLGHMIVTL--VARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15115   220 LSLYG----DPPLSKVLMSWdhLSIALAYANSCLNPVLYVFMGKDFKK 263
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
45-334 5.87e-24

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 100.21  E-value: 5.87e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVP---VDASryffDEWVFGKLGCKLIPA 121
Cdd:cd15174     2 FLPPLYWLIFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLFLCT-LPfwaTAAS----SGWVFGTFLCKVVNS 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 122 IQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGV--VLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTaci 199
Cdd:cd15174    77 MYKINFYSCMLLLTCISVDRYIAIVQATKAHNSKNkrLLYSKLVCFFVWLLSTILSLPEILFSQSKEEESVTTCTMV--- 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 200 pYPQTDELHPKIHS-VLIFLVYFLIPLVIISIYYYHIAKTLIRSahnlpgeynehtkKQMETRKRLaKIVLVFVGCFVFC 278
Cdd:cd15174   154 -YPSNESNRFKVAVlALKVTVGFFLPFVVMVICYTLIIHTLLQA-------------KRFQKHKAL-KVIIAVVTVFVLS 218
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 279 WFPNHILYLYRSFNYKEI-----DPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKH 334
Cdd:cd15174   219 QLPYNSILLIKTINAYNItitdcATSQNLDIAGQVTQSIAFLHSCLNPFLYVFVGVRFRKD 279
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
44-335 6.55e-24

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 100.04  E-value: 6.55e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  44 CVIpslYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASrYFFDEWVFGKLGCKLIPAIQ 123
Cdd:cd15178     4 CVI---YVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALT-LPFWAV-SVVKGWIFGTFMCKLVSLLQ 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGvVLWTSLKAVGIWVVSVLLAVPEAVFSEVARigsSDNSSFTACIPY-- 201
Cdd:cd15178    79 EANFYSGILLLACISVDRYLAIVHATRALTQK-RHLVKFVCAGVWLLSLLLSLPALLNRDAFK---PPNSGRTVCYENlg 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 202 PQTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRsAHNLpgeynehtKKQmetrkRLAKIVLVFVGCFVFCWFP 281
Cdd:cd15178   155 NESADKWRVVLRILRHTLGFLLPLVVMLFCYGFTIKTLLQ-TRSF--------QKH-----RAMRVIFAVVLAFLLCWLP 220
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958642650 282 NHILY----LYRSFNYKEIDPSLGHMIVTL-VARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15178   221 YNVTVlidtLMRTKLITETCELRNHVDVALyVTQILGFLHSCINPVLYAFIGQKFRNNL 279
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
46-335 1.09e-23

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 99.14  E-value: 1.09e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASrYFFDEWVFGKLGCKLIPAIQLT 125
Cdd:cd15186     3 LSIFYSLVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLFVAT-LPFWTH-YLINEWGLHNAMCKLTTAFFFI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 126 SVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEvarigSSDNSsftaCIP-YPQT 204
Cdd:cd15186    81 GFFGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAVPQFMFTK-----MKENE----CLGdYPEV 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 -DELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIrsahnlpgeYNEHTKKqmetrKRLAKIVLVFVGCFVFCWFPNH 283
Cdd:cd15186   152 lQEIWPVLRNVELNFLGFLLPLLIMSYCYFRIIQTLF---------SCKNHKK-----ARAIKLILLVVIVFFLFWTPYN 217
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642650 284 ILYLYRSFNYKEIDPSLGhMIVTL-----VARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15186   218 VMIFLETLKLYDFFPSCD-MKKDLrlalsVTETIAFSHCCLNPLIYAFAGEKFRRYL 273
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
50-333 1.39e-23

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 99.14  E-value: 1.39e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  50 YLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGV 129
Cdd:cd15396     7 YSVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMCIPFTAVYTLMDHWIFGETMCKLTSFVQSVSVSV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 130 SVFTLTALSADRYRAIVNPMDMQTS------GVVLwtslkavgIWVVSVLLAVPEAVFSEVARIGSSDNSSFT------- 196
Cdd:cd15396    87 SIFSLVLIAIERYQLIVNPRGWKPSashaywGIVL--------IWLFSLMISIPFLIFHQLTDEPFRNLSSHSdfykdkv 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 197 ACIPY--PQTDELhpkIHSVLIFLVYFLIPLVIISIYYYHIAKTLiRSAHNLPGEYNEHTKKQMETrKRLAKIVLVFVGC 274
Cdd:cd15396   159 VCIEAwpSETERL---IFTTSLLVFQYFVPLGFIFICYLKIFVCL-KKRNSKIDRMRENESRLSEN-KRINTMLISIVVT 233
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958642650 275 FVFCWFPNHILYLYRSFNYkEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15396   234 FAACWLPLNIFNVVFDWNH-EVLMSCHHNLVFTLCHLVAMVSTCINPIFYGFLNKNFQK 291
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
45-335 1.95e-23

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 98.34  E-value: 1.95e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15063     2 ISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTsgvvLWTSLKA----VGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACip 200
Cdd:cd15063    82 WMCTASILNLCAISLDRYLAITRPIRYPS----LMSTKRAkcliAGVWVLSFVICFPPLVGWNDGKDGIMDYSGSSSL-- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 201 yPQTDEL-HPKIHSVLIFLVYFLIPLVIISIYYYHIAKTlirsahnlpgeynehtkKQMETRKrlAKIVLVFVGCFVFCW 279
Cdd:cd15063   156 -PCTCELtNGRGYVIYSALGSFYIPMLVMLFFYFRIYRA-----------------ARMETKA--AKTVAIIVGCFIFCW 215
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 280 FPNHILYLYRSFNYKEIDPslghmIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15063   216 LPFFTVYLVRAFCEDCIPP-----LLFSVFFWLGYCNSALNPCIYALFSRDFRFAF 266
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
46-333 3.09e-23

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 98.00  E-value: 3.09e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLT 125
Cdd:cd15194     3 LPILYCLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPLWVDKEVVLGPWRSGSFLCKGSSYIISV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 126 SVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSdnssftaciPYPQTD 205
Cdd:cd15194    83 NMYCSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPTLLSRELKKYEEK---------EYCNED 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 206 ELHP--KIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRsahnlpgEYNEHTKKQMETRKRLaKIVLVFVGCFVFCWFP-N 282
Cdd:cd15194   154 AGTPskVIFSLVSLIVAFFLPLLSILTCYCTIIWKLCH-------HYQKSGKHQKKLRKSI-KIVFIVVAAFVFSWMPfN 225
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958642650 283 HILYLYRSFNYKEIDPSLGHMIVTL---VARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15194   226 LFKALAIASGLQVEVTCLPYTLAQLgmeVSAPLAFANSCANPFIYYFFDRYIRR 279
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
49-335 4.74e-23

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 97.88  E-value: 4.74e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLvkIFLTNSTM-RSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDE-WVFGKLGCKLIPAIQLTS 126
Cdd:cd15117     6 IYSSAFVLGTLGNGLV--IWVTGFRMtRTVTTVCFLNLAVADFAFCLF-LPFSVVYTALGFhWPFGWFLCKLYSTLVVFN 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 127 VGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVaRIGSSDNSSFTACIPYPQT-- 204
Cdd:cd15117    83 LFASVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSGPHLVFRDT-RKENGCTHCYLNFDPWNETae 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 -----DELHPKIHSVLI---FLVYFLIPLVIISIYYYHIAKTLIRsahnlpgeynehtkKQMETRKRLAKIVLVFVGCFV 276
Cdd:cd15117   162 dpvlwLETVVQRLSAQVitrFVLGFLVPLVIIGGCYGLIAARLWR--------------EGWVHSSRPFRVLTAVVAAFF 227
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 277 FCWFPNHILYLYRSFNYKEIDPSLGHMIVTLV--ARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15117   228 LCWFPFHLVSLLELVVILNQKEDLNPLLILLLplSSSLACVNSCLNPLLYVFVGRDFRERL 288
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
49-333 6.03e-23

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 97.70  E-value: 6.03e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIfLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLG-----CKLIPAIQ 123
Cdd:cd14978     6 VLPVICIFGIIGNILNLVV-LTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYfyayfLPYIYPLA 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACIP--Y 201
Cdd:cd14978    85 NTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPtlL 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 202 PQTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRS---AHNLPGEYNEHTKKQMETRkRLAKIVLVFVGCFVFC 278
Cdd:cd14978   165 RQNETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSkkrRRLLRRRRRLLSRSQRRER-RTTIMLIAVVIVFLIC 243
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 279 WFPNHILYLYRSFnYKEIDPSLGHMIVTLVARVLSFSNSCVNpFALYLL-SESFRK 333
Cdd:cd14978   244 NLPAGILNILEAI-FGESFLSPIYQLLGDISNLLVVLNSAVN-FIIYCLfSSKFRR 297
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
45-335 7.25e-23

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 97.17  E-value: 7.25e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15056     2 VLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLDV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMdMQTSGVVLWTSLKAVGIWVVSVLLAVpEAVFSEVARIGSSDNSSFTACIPYPQT 204
Cdd:cd15056    82 LLTTASIMHLCCIALDRYYAICCQP-LVYKMTPLRVAVMLGGCWVIPTFISF-LPIMQGWNHIGIEDLIAFNCASGSTSC 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAH---------NLPGEYNEHTKKQMETRKRLAKIVLVFVGCF 275
Cdd:cd15056   160 VFMVNKPFAIICSTVAFYIPALLMVLAYYRIYVAAREQAHqirslqragSSNHEADQHRNSRMRTETKAAKTLGIIMGCF 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 276 VFCWFPNHILYLyrsfnykeIDPSLGHMIVTLVARV---LSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15056   240 CVCWAPFFVTNI--------VDPFIGYRVPYLLWTAflwLGYINSGLNPFLYAFFNKSFRRAF 294
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
49-335 7.30e-23

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 97.23  E-value: 7.30e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd15127     6 LSVVIFGIGIMGNVAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLGDFSCKIVPYIEVASLG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNpMDMQTSGVVLWTSLKA--VGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACIPYPQTDE 206
Cdd:cd15127    86 VTTFTLCALCIDRFRAATN-VQMYYEMIENCTSTTAklAVIWVGALLLALPEVVLRQLSKEDGGSGAPPAERCVVKISTE 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 207 LHPKIHSVLI----------FLVYFLIPlVIISIYYYHIAKTLIRSAHNLPGEYNehtKKQMETRKRLAKIVLVFVGCFV 276
Cdd:cd15127   165 LPDTIYVLALtydgarlwwyFGCYFCLP-TLFTITCSLVTARKIRRAEKACTRGN---KRQIQLESQMNCTVVALTILYG 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958642650 277 FCWFPNHILYLYRSFNYKEIDPSLGHMIvTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15127   241 FCIIPENICNIVTAYMATGVSRQTMDLL-HLISQFLLFFKSCVTPVLLFCLCRPFSRAF 298
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
46-335 1.28e-22

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 96.36  E-value: 1.28e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLT 125
Cdd:cd15162     3 LPAVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHIHGNNWIFGEALCRLVTVAFYG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 126 SVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDnssFTACIPYPQTD 205
Cdd:cd15162    83 NMYCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLVKQTIFLPALD---ITTCHDVLPEQ 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 206 ELHPKIHSVLI--FLVYFLIPLVIISIYYYHIAKTLIRSAHnlpgEYNEHTKKQMetrKRLAKIVLVFvgcFVFCWFPNH 283
Cdd:cd15162   160 LLVGDWFYYFLslAIVGFLIPFILTASCYVATIRTLAALED----ENSEKKKKRA---IKLAATVLAI---FIICFAPSN 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 284 IL----YLYRSFNYKEidpslGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15162   230 LLllahYSLISSSGTG-----HLYFAYLLALCLSTLNSCIDPFIYYFVSKEFRDHV 280
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
45-335 1.44e-22

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 95.98  E-value: 1.44e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDAsRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15184     2 LLPPLYSLVFIFGFVGNMLVVLILINCKKLKSMTDIYLLNLAISDLLFLLT-LPFWA-HYAANEWVFGNAMCKLLTGLYH 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARigssDNSSFTACIPYPQT 204
Cdd:cd15184    80 IGFFSGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVVTWVVAVFASLPGIIFTKSQK----EGSHYTCSPHFPPS 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHPK-IHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNlpgeynehtkkqmETRKRLAKIVLVFVGCFVFCWFPNH 283
Cdd:cd15184   156 QYQFWKnFQTLKMNILGLVLPLLVMIICYSGILKTLLRCRNE-------------KKRHKAVRLIFTIMIVYFLFWAPYN 222
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958642650 284 ILYLYRSF------NYKEIDPSLGHmiVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15184   223 IVLLLNTFqeffglNNCSSSNRLDQ--AMQVTETLGMTHCCINPVIYAFVGEKFRSYL 278
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
48-335 1.51e-22

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 96.34  E-value: 1.51e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  48 SLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSV 127
Cdd:cd15000     4 SMFLPVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSLL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLkaVGIWVVSVLLAVPEAVFSE-VARIGSSDNSSFTAcipyPQTDE 206
Cdd:cd15000    84 LASVLALCAVSYDRLTAIVLPSEARLTKRGAKIVI--VITWIVGLLLALPLAIYRSyRERQWKNFLETYCA----ENTQV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 207 LHPKIHSVLIFLVYFliPLVIISIYYYHIAKTLIRSAHNLPGEYNEHtkkQMETRKRLAKIVLVFVGCFVFCWFPNHILY 286
Cdd:cd15000   158 LPIYWHVIITVLVWL--PLGIMLICYSAIFWKLDKYERRVLRREHPS---VVRYKKKAAKTLFIVLITFVVCRIPFTALI 232
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 287 LYRSFNYKEIDP----SLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15000   233 FYRYKLVPNDNTqnsvSGSFHILWFASKYLMFLNAAVNPLIYGFTNENFRKAF 285
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
45-333 2.30e-22

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 95.86  E-value: 2.30e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15083     2 VLGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAV-FSEVARIGSSDNSSFTacipYPQ 203
Cdd:cd15083    82 LFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFgWSRYVLEGLLTSCSFD----YLS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELhPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTKKQMETRK-------RLAKIVLVFVGCFV 276
Cdd:cd15083   158 RDDA-NRSYVICLLIFGFVLPLLIIIYCYSFIFRAVRRHEKAMKEMAKRFSKSELSSPKarrqaevKTAKIALLLVLLFC 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642650 277 FCWFPNHILYLYRSFNYKEIDPSlghmIVTLVARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15083   237 LAWTPYAVVALIGQFGYLEVLTP----LATAIPAAFAKTSAIYNPVIYAFSHPKFRR 289
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
45-335 3.61e-22

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 95.26  E-value: 3.61e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFD-EWVFGKLGCKLIPAIQ 123
Cdd:cd15921     2 FYPTAYILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCT-LPLRLTYYVLNsHWPFGDIACRIILYVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEvarigSSDNSSFTACIPYPQ 203
Cdd:cd15921    81 YVNMYSSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPLLFAKS-----KQHDEGSTRCLELAH 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLpgeynehtKKQMETRKRLAKIVLVFVGCFVFCWFPNH 283
Cdd:cd15921   156 DAVDKLLLINYVTLPVGFVVPFMTVIFCYIFIIKNLLKPSPAL--------GRTRPSRRKACALIIISLGIFLVCFLPYH 227
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 284 ILYLYRSFNYKEIDPSLGHMIVTLVARV----LSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15921   228 IVRTIHLITERQIKESCGYILRVRKAAVitlcLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
46-334 9.64e-22

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 93.65  E-value: 9.64e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVP---VDASryffDEWVFGKLGCKLIPAI 122
Cdd:cd15176     3 LPVFYTIALVVGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLLLFT-LPfwaADAV----NGWVLGTAMCKITSAL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 123 QLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVgiWVVSVLLAVPEAVFSEVArigssDNSSFTACIP-Y 201
Cdd:cd15176    78 YTMNFSCGMQFLACISVDRYVAITKATSRQFTGKHCWIVCLCV--WLLAILLSIPDLVFSTVR-----ENSDRYRCLPvF 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 202 PQTDELHPKIH-SVLIFLVYFLIPLVIISIYYYHIAKTLIRsAHNLpgeynehtkkqmeTRKRLAKIVLVFVGCFVFCWF 280
Cdd:cd15176   151 PPSLVTSAKATiQILEVLLGFVLPFLVMVFCYSRVARALSR-TPNV-------------KKSRALKVLLAVVGVFIVTQL 216
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958642650 281 PNHILYLYRSFN-----YKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKH 334
Cdd:cd15176   217 PYNVVKFYRAIDviyllITDCSMSKTLDIAIQVTESIALFHSCLNPVLYVFMGASFKSH 275
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
45-333 9.93e-22

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 93.78  E-value: 9.93e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMlVKIFLTNSTMRSVP--NIFISNLAAGDLLLLLTcVPVDASRYFFD-EWVFGKLGCKLIPA 121
Cdd:cd15925     2 LVALAYGLVCAIGLLGNLA-VMYLLRNCARRAPPpiDVFVFNLALADFGFALT-LPFWAVESALDfHWPFGGAMCKMVLT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 122 IQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDnssfTACIPY 201
Cdd:cd15925    80 ATVLNVYASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAALLATVPTAIFATEGEVCGVE----LCLLKF 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 202 PQTDELhpKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNlpgeynehtKKQMETRKRLAKIVLVFVGCFVFCWFP 281
Cdd:cd15925   156 PSNYWL--GAYHLQRVVVAFVVPLGVITTSYLLLLSFLQQHKVN---------QNNRQRQSVIARSVRLVVASFFLCWFP 224
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958642650 282 NH------ILYLYRSFNYKEIDPSLgHMIVTLVARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15925   225 NHvvtfwgVLVKFRAVPWNSTFYFI-HTYVFPVTTCLAHSNSCLNPVLYCLMRREFRQ 281
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
46-335 3.57e-21

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 92.13  E-value: 3.57e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASrYFFDEWVFGKLGCKLIPAIQLT 125
Cdd:cd15172     3 VPVIYSLICVVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADILFVLT-LPFWAV-YEAHQWIFGNFSCKLLRGIYAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 126 SVGVSVFTLTALSADRYRAIVN---PMDMQTSgVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNssfTACIPYP 202
Cdd:cd15172    81 NFYSGMLLLACISVDRYIAIVQatkSFRLRSR-TLAYSKLICAAVWLLAILISLPTFIFSEVYDFGLEEQ---YVCEPKY 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 203 QTDELHPKIHSVLIFL---VYFLIPLVIISIYYYHIAKTLIRsAHNLpgeynehtkkqmeTRKRLAKIVLVFVGCFVFCW 279
Cdd:cd15172   157 PKNSTAIMWKLLVLSLqvsLGFFIPLLVMIFCYSFIIKTLLQ-AQNS-------------QRHKAVRVVVAVVLVFLVCQ 222
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958642650 280 FPNHILYLYRSFNYKEIDPSLGHMIVTL---VARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15172   223 VPYNIVLLIEAINLGEQQSCSSEKAVAYaktITECLAFFHCCLNPVLYAFIGVKFRNYF 281
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
45-335 6.55e-21

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 91.66  E-value: 6.55e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGllGNIM-LVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQ 123
Cdd:cd15383     4 VAVTFVLFVLSAC--SNLAvLWSATRNRRRKLSHVRILILHLAAADLLVTFVVMPLDAAWNVTVQWYAGDLACRLLMFLK 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDM----QTSGVVLWTSlkavgiWVVSVLLAVPEAVFSEVARIGSSDNssFTACI 199
Cdd:cd15383    82 LFAMYSSAFVTVVISLDRHAAILNPLAIgsarRRNRIMLCAA------WGLSALLALPQLFLFHTVTATPPVN--FTQCA 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 200 ---PYPQtdELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNL----PGEYNEHTKKQMETRKRLA--KIVLV 270
Cdd:cd15383   154 thgSFPA--HWQETLYNMFTFFCLFLLPLLIMIFCYTRILLEISRRMKEKkdsaKNEVALRSSSDNIPKARMRtlKMTIV 231
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958642650 271 FVGCFVFCWFPNHIL---YLYR-SFNYKEIDPSLGHMIVtlvarVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15383   232 IVSSFIVCWTPYYLLglwYWFSpEMLEQTVPESLSHILF-----LFGLLNACLDPLIYGLFTISFRRGL 295
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
45-335 8.08e-21

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 91.31  E-value: 8.08e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFD-EWVFGKLGCKLIPAIQ 123
Cdd:cd15157     2 IYPTVYLIIFVLGVVGNGLSIYVFLQPSKKKTSVNIFMLNLAVSDLMFVST-LPFRADYYLMGsHWVFGDIACRIMSYSL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVsVLLAVPEAVFSevariGSSDNSSFTACIpypq 203
Cdd:cd15157    81 YVNMYCSIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARILCAVIWIF-VMAASSPLLSK-----GTSKYNSQTKCL---- 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 tdELHPKIHSVLIFLVY------FLIPLVIISIYYYHIAKTLIRSahNLPgeyneHTKKQMETRKRLAKIVLVFVgCFVF 277
Cdd:cd15157   151 --DLHPSKIDKLLILNYivlvvgFILPFCTLSICYILIIKALLKP--RVP-----QSKLRVSHKKALLTIIITLI-LFLL 220
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 278 CWFPNHIL---YLYRSFNYKEIDPSLGHMIVTLvarVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15157   221 CFLPYHILrtvHLMQWSEGQCNLRLHKAVVITL---CLAAANSCLDPLLYYFAGENFKERL 278
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
46-334 1.08e-20

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 91.01  E-value: 1.08e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDAsRYFFDEWVFGKLGCKLIPAIQLT 125
Cdd:cd15187     3 LPVLYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLFVFS-LPFQA-YYLLDQWVFGNAMCKIVSGAYYI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 126 SVGVSVFTLTALSADRYRAIVN---PMDMQTSGVVLWTSLkavGIWVVSVLLAVPEAVFSEVArigSSDNSsfTACIP-Y 201
Cdd:cd15187    81 GFYSSMFFITLMSIDRYLAIVHavyALKVRTASHGTILSL---ALWLVAILASVPLLVFYQVA---SEDGR--LQCIPfY 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 202 PQTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIaktlirsAHNLPGEYNEHTKKQMetrkrlaKIVLVFVGCFVFCWFP 281
Cdd:cd15187   153 PGQGNSWKVFTNFEVNILGLLIPFSILIFCYHNI-------LRNLRRCHNQNKTKAI-------KLVFIVVIVFFLFWTP 218
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642650 282 -NHILYLYRSFNYKEIDPSLGHMIVTL---VARVLSFSNSCVNPFALYLLSESFRKH 334
Cdd:cd15187   219 fNVVLFLDSLHSLHIIDGCQNSQRLTLalhLTETISFTHCCLNPVIYAFVGEKFKKH 275
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
46-333 1.10e-20

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 90.98  E-value: 1.10e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRyFFDEWVFGKLGCKLIPAIQLT 125
Cdd:cd15175     3 LPAMYSVICFLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADILFLLT-LPFWAAS-AAKKWVFGEEMCKAVYCLYKM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 126 SVGVSVFTLTALSADRYRAIVNPMDMQ--TSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVarigsSDNSSFTACIPYPQ 203
Cdd:cd15175    81 SFFSGMLLLMCISIDRYFAIVQAASAHrhRSRAVFISKVSSLGVWVLAFILSIPELLYSGV-----NNNDGNGTCSIFTN 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 T-DELHPKIHSVLIFLVyFLIPLVIISIYYYHIAKTLIRSahnlpgeynehtkKQMETRKRLaKIVLVFVGCFVFCWFPN 282
Cdd:cd15175   156 NkQTLSVKIQISQMVLG-FLVPLVVMSFCYSVIIKTLLQA-------------RNFEKNKAI-KVIIAVVVVFVVFQLPY 220
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 283 HILYLYR---SFNYKEIDPSLGH--MIVTLVARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15175   221 NSVMLVStlsSFKGNTTDCDYSKnlDFALDVTYSLACFRCCLNPFLYAFIGVKFRN 276
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
45-333 1.42e-20

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 90.73  E-value: 1.42e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMR-SVPNIFISNLAAGDLLLLLTcVPVDASRYFFD-EWVFGKLGCKLIPAI 122
Cdd:cd15926     2 IISIVYSVVCALGLVGNLLVLYLMKSKQGWKkSSINLFVTSLAVTDFQFVLT-LPFWAVENALDfTWLFGKAMCKIVSYV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 123 QLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDnssfTACIPYP 202
Cdd:cd15926    81 TAMNMYASVFFLTAMSVARYHSVASALKSKRRRGCCSAKWLCVLIWVLAILASLPNAIFSTTATVSNEE----LCLVKFP 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 203 QTD---ELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGeynehTKKqmetRKRLAKIVLVFVGCFVFCW 279
Cdd:cd15926   157 DNRgnaQFWLGLYHAQKVLLGFLIPLGIISLCYLLLVRFITDKNITGSS-----TKR----RSKVTKSVTIVVLSFFLCW 227
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958642650 280 FPNHILYLYR--------SFNYKEIdpsLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15926   228 LPNQALTTWGiliklnvvHFSYEYF---TTQVYIFPITVCLAHSNSCLNPILYCLMRREFRK 286
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
56-332 1.49e-20

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 90.71  E-value: 1.49e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  56 VGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLtCVPVDASRYF-FDEWVFGKLGCKLIPAIQLTSVGVSVFTL 134
Cdd:cd15131    13 VGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFL-CMPLDLYRLWqYRPWNFGDLLCKLFQFVSESCTYSTILNI 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 135 TALSADRYRAIVNPMDMQTsgVVLWTSLKAV--GIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACIPYPQTDELHPKIH 212
Cdd:cd15131    92 TALSVERYFAICFPLRAKV--VVTKRRVKLVilVLWAVSFLSAGPIFVLVGVEHENGTNPIDTNECKATEYAVRSGLLTI 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 213 SVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTKKqmeTRKRLAKIVLVFVGCFVFCWFPNHI-LYLY-RS 290
Cdd:cd15131   170 MVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRRENIGPNASHRDK---NNRQTVKMLAVVVFAFVLCWLPFHVgRYLFsKS 246
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1958642650 291 FNYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFR 332
Cdd:cd15131   247 FEAGSLEIALISQYCNLVSFVLFYLSAAINPILYNIMSKKYR 288
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
49-335 1.83e-20

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 90.59  E-value: 1.83e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd15058     6 LLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPMDMQtsgvVLWTSLKA----VGIWVVSVLLA-VPeaVFSEVARigsSDNSSFTACIPYPQ 203
Cdd:cd15058    86 ASIETLCVIAVDRYIAITRPLRYQ----VLLTKRRArvivCVVWIVSALVSfVP--IMNQWWR---ANDPEANDCYQDPT 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELHPKIHSVLI-FLVYFLIPLVIISIYY---YHIAKTLIR----------SAHNLPGEYNEHTKKQMETRK------- 262
Cdd:cd15058   157 CCDFRTNMAYAIAsSVVSFYIPLLIMIFVYarvFLIATRQLQlidkrrlrfqSECPAPQTTSPEGKRSSGRRPsrltvvk 236
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958642650 263 --RLAKIVLVFVGCFVFCWFPNHILYLYRSFNykeidPSLGHMIVTLVARVLSFSNSCVNPFaLYLLSESFRKHF 335
Cdd:cd15058   237 ehKALKTLGIIMGTFTLCWLPFFIANIINVFN-----RNLPPGEVFLLLNWLGYINSGLNPI-IYCRSPEFRTAF 305
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
45-332 1.84e-20

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 90.19  E-value: 1.84e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNsTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFF-DEWVFGKLGCKLIPAIQ 123
Cdd:cd15372     2 LVPSLYTLVFLVGLPANGLALWVLATQ-VKRLPSTIFLINLAVADLLLILV-LPFKISYHFLgNNWPFGEGLCRVVTAFF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACIPYpQ 203
Cdd:cd15372    80 YGNMYCSVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQRQSYPLERLNITLCHDVLPL-D 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSahnlpGEYNEHTkkqmetrKRLAKIVLVfvgCFVFCWFPNH 283
Cdd:cd15372   159 EQDTYLFYYFACLAVLGFLLPLVVILFCYGSVLHTLLRS-----GQRYGHA-------MKLTVLVLV---SFVLCFTPSN 223
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 284 ILYLyrsFNYKEIDPSLGHM--IVTLVARVLSFSNSCVNPFALYLLSESFR 332
Cdd:cd15372   224 LLLL---LHYSDPTLDDGGNlyIVYMVSLAISTLNSCVDPFIYYYVSEEFR 271
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
46-335 1.96e-20

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 90.19  E-value: 1.96e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDeWVFGKLGCKLIPAIQLT 125
Cdd:cd15181     3 IPLAYSLVFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLLLLLT-FPFSVVESIAG-WVFGTFLCKLVGAIHKL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 126 SVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVArigSSDNSSFTACiPYPQTD 205
Cdd:cd15181    81 NFYCSSLLLACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFLLSLPNLVFLEVE---TSTNANRTSC-SFHQYG 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 206 ELHPKIHSVLIFL---VYFLIPLVIISIYYYHIAKTLIRSAHNLpgeynehtkkqmeTRKRLAKIVLVFVGCFVFCWFPN 282
Cdd:cd15181   157 IHESNWWLTSRFLyhvVGFFLPLLIMGYCYATIVVTLCQSSRRL-------------QKQKAIRVAILVTLVFCLCWLPY 223
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 283 HILYLYRSF-------NYKEIDPSLGHMIvtLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15181   224 NIVIFLDTLddlkavvKNCKLNDLLDAAI--TVTESLGFSHCCLNPILYAFIGVKFRNDL 281
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
51-335 4.39e-20

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 89.38  E-value: 4.39e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  51 LIIISVglLGNI-MLVKIFLTNSTmRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGV 129
Cdd:cd15195    10 LFVISA--AGNLtVLIQLFRRRRA-KSHIQILIMHLALADLMVTFFNMPMDAVWNYTVEWLAGDLMCRVMMFLKQFGMYL 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 130 SVFTLTALSADRYRAIVNPM---DMQTSGVVLWTSlkavgIWVVSVLLAVPEA-VFSEVARigSSDNSSFTACIPYPQ-T 204
Cdd:cd15195    87 SSFMLVVIALDRVFAILSPLsanQARKRVKIMLTV-----AWVLSALCSIPQSfIFSVLRK--MPEQPGFHQCVDFGSaP 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLI---RSAHNLPGEYNEHTKKQM--ETRKRLAKIVLVFVGCFVFCW 279
Cdd:cd15195   160 TKKQERLYYFFTMILSFVIPLIITVTCYLLILFEISkmaKRARDTPISNRRRSRTNSleRARMRTLRMTALIVLTFIVCW 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 280 FPNHILYLYRSFNYKEIDPSLGHMIVTLVarVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15195   240 GPYYVLGLWYWFDKESIKNLPPALSHIMF--LLGYLNPCLHPIIYGVFMKEIRNWI 293
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
45-332 5.31e-20

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 89.09  E-value: 5.31e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDlLLLLTCVPVDAS--RYFFDeWVFGKLGCKLIPAI 122
Cdd:cd15380     2 VLPTFIIAICFFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASD-LVFVLGLPFWAEniRNQFN-WPFGNFLCRVISGV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 123 QLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIgssDNSSFTACIpyp 202
Cdd:cd15380    80 IKANLFISIFLVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSIPTFLFRSVKHV---PDLNISACI--- 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 203 qTDELHPKIHSVLIF---LVYFLIPLVIISIYYYHIaktlIRSahnLPGEYNEHTKKQMETR-KRLAKIVLVFVGCFVFC 278
Cdd:cd15380   154 -LLFPHEAWHFARRVelnIVGFLLPLAAIVFFNFHI----IAS---LRERTEESRKRCGGLKdTKATRLILTLVLMFLVC 225
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958642650 279 WFPNHIL-YLYRSFNYKEIDPSLGHMIVTL---VARVLSFSNSCVNPFALYLLSESFR 332
Cdd:cd15380   226 WTPYHFFaFLDFLFQVEVIQGCFWEEFIDLglqLANFFAFANSCLNPVIYVFAGKLFR 283
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
54-335 5.93e-20

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 88.41  E-value: 5.93e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  54 ISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSVFT 133
Cdd:cd15326    11 ILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILS 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 134 LTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAV-PEAVFSEVArigSSDNssfTACipyPQTDELHPKIH 212
Cdd:cd15326    91 LCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIgPLLGWKEPA---PPDD---KVC---EITEEPFYALF 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 213 SVlifLVYFLIPLVIISIYY---YHIAKTLIRsahnlpgeynehtkkqmetRKRLAKIVLVFVGCFVFCWFPNHILYLYR 289
Cdd:cd15326   162 SS---LGSFYIPLIVILVMYcrvYIVALKFSR-------------------EKKAAKTLGIVVGMFILCWLPFFIALPLG 219
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1958642650 290 SFNYKEIDPSlghmIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15326   220 SLFSHLKPPE----TLFKIIFWLGYFNSCLNPIIYPCSSKEFKRAF 261
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
45-335 6.07e-20

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 88.93  E-value: 6.07e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15051     2 VLGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLDV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSgVVLWTSLKA-VGIWVVSVLLA-VPEAVFSEVARIGSSDNSSFTACipyp 202
Cdd:cd15051    82 MLCTASILNLFAISLDRYLAITAPLRYPSR-VTPRRVAIAlAAIWVVSLAVSfLPIHLGWNTPDGRVQNGDTPNQC---- 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 203 qTDELHPkIHSVLIFLVYFLIPLVIISIYYYHIAKTL------IRSAHnlPGEYNEHTKKQMETRKRLAKIVLVFV-GCF 275
Cdd:cd15051   157 -RFELNP-PYVLLVAIGTFYLPLLIMCGVYLRIFRIAreqakrINALT--PASTANSSKSAATAREHKATVTLAAVlGAF 232
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 276 VFCWFPNHILYLYRSFNYKEIdPSLGHMIVTLvarvLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15051   233 IICWFPYFTYFTYRGLCGDNI-NETALSVVLW----LGYANSALNPILYAFLNRDFRRAF 287
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
37-340 8.83e-20

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 88.64  E-value: 8.83e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  37 TAELVIRCVipsLYLIIIsvglLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGC 116
Cdd:cd15197     1 TEQLATLWV---LFVFIV----VGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDIIWRITVEWRAGDFAC 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 117 KLIPAIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVlwTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFt 196
Cdd:cd15197    74 KVIRYLQVVVTYASTYVLVALSIDRYDAICHPMNFSQSGRQ--ARVLICVAWILSALFSIPMLIIFEKTGLSNGEVQCW- 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 197 acIPYPQTDELHPKIhSVLIFLVYFlIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTKKQMETRK-----------RLA 265
Cdd:cd15197   151 --ILWPEPWYWKVYM-TIVAFLVFF-IPATIISICYIIIVRTIWKKSKIQVTINKAGLHDGSSRRSssrgiiprakiKTI 226
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958642650 266 KIVLVFVGCFVFCWFPNHILYLYRSFNykEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLlsesfrkhFNSQLC 340
Cdd:cd15197   227 KMTFVIVTVFIICWSPYFVFDLLDVFG--LLPRSKTKIAAATFIQSLAPLNSAINPLIYCL--------FSTHLC 291
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
49-335 1.33e-19

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 87.90  E-value: 1.33e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLvkIFLTNSTM-RSVPNIFISNLAAGDLLLLLTcVPVDASRYFFD-EWVFGKLGCKLIPAIQLTS 126
Cdd:cd15116     6 IYSVVFVLGVLGNGLV--IFITGFKMkKTVNTVWFLNLAVADFLFTFF-LPFSIAYTAMDfHWPFGRFMCKLNSFLLFLN 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 127 VGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVA------RIGSSDNSSFTACIP 200
Cdd:cd15116    83 MFTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIFRDTApsqnnnKIICFNNFSLSGDNS 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 201 YPQTDELHPKIHSVLI---FLVYFLIPLVIISIYYYHIAKTLIRSahnlpgeynehtkkQMETRKRLAKIVLVFVGCFVF 277
Cdd:cd15116   163 SPEVNQLRNMRHQVMTitrFLLGFLIPFTIIICCYAAIVLKLKRN--------------RLAKSSKPFKIIAAVIVTFFL 228
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 278 CWFPNHILYLYRSFNYKEIDP--SLGHMIVTlvarVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15116   229 CWAPYHILNLLEMEATRSPASvfKIGLPITS----SLAFINSCLNPILYVFMGQDFKKFK 284
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
55-335 2.23e-19

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 87.03  E-value: 2.23e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  55 SVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDE-WVFGKLGCKLIPAIQLTSVGVSVFT 133
Cdd:cd15067    11 LVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGGyWLFGRDWCDVWHSFDVLASTASILN 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 134 LTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFsevARIGSSDNSSFTACIpypQTDElhpKIHS 213
Cdd:cd15067    91 LCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFPAIAW---WRAVDPGPSPPNQCL---FTDD---SGYL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 214 VLIFLVYFLIPLVIISIYYYHIAKTLIRsahnlpgeynehtkkqmetRKRLAKIVLVFVGCFVFCWFPNHILYLYRSFNY 293
Cdd:cd15067   162 IFSSCVSFYIPLVVMLFTYYRIYRAAAK-------------------EQKAAKTLGIVMGVFILCWLPFFVTNILIGFCP 222
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1958642650 294 KEI--DPSLGHMIVTLvarvLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15067   223 SNCvsNPDILFPLVTW----LGYINSGMNPIIYACSSRDFRRAF 262
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
46-333 2.50e-19

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 87.10  E-value: 2.50e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISV-GLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15073     2 IVAAYLIVAGIiSTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNP-----MDMQTSGVVlwtslkAVGIWVVSVLLA-VPEAVFSEVArigsSDNSSFTAC 198
Cdd:cd15073    82 FFGMASIGLLTVVAVDRYLTICRPdlgrkMTTNTYTVM------ILLAWTNAFFWAaMPLVGWASYA----LDPTGATCT 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 199 IPYPQTDELHpKIHSVLIFLVYFLIPLVIISIYYYHIAKTLirsAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFVFC 278
Cdd:cd15073   152 INWRKNDSSF-VSYTMSVIVVNFIVPLAVMFYCYYNVSRFV---KKVLASDCLESVNIDWTDQNDVTKMSVIMIVMFLVA 227
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 279 WFPNHILYLYRSF-NYKEIDPSLghmivTLVARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15073   228 WSPYSIVCLWASFgEPKKIPPWM-----AIIPPLFAKSSTFYNPCIYVIANKKFRR 278
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
49-335 2.96e-19

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 86.33  E-value: 2.96e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd15060     6 LLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCDILCCT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAvfsevarIGSSDNS-SFTACIPYPQTDEL 207
Cdd:cd15060    86 ASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPL-------IGWNDWPeNFTETTPCTLTEEK 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 208 HPKIHSVlifLVYFLIPLVIISIYYYHIAKTlirsahnlpgeynehTKKQmetrKRLAKIVLVFVGCFVFCWFPNHILYL 287
Cdd:cd15060   159 GYVIYSS---SGSFFIPLLIMTIVYVKIFIA---------------TSKE----RRAARTLGIIMGVFVVCWLPFFLMYV 216
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1958642650 288 YRSFnykeIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15060   217 ILPF----CETCSPSAKVVNFITWLGYVNSALNPVIYTIFNLDFRRAF 260
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
46-333 4.73e-19

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 86.36  E-value: 4.73e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVP---VDASRyffdEWVFGKLGCKLIPAI 122
Cdd:cd15179     3 LPTVYSIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVLT-LPfwaVDAAA----NWYFGNFLCKAVHVI 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 123 QLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVarigSSDNSSFTACIPYP 202
Cdd:cd15179    78 YTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWLPALLLTVPDLVFAKV----SELDDRYICDRIYP 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 203 Q-TDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSahnlpgeynehtkKQMETRKRLaKIVLVFVGCFVFCWFP 281
Cdd:cd15179   154 EdTFELWVVAFRFQHILVGLVLPGLVILTCYCIIISKLSHS-------------KGHQKRKAL-KTTVILILAFFACWLP 219
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642650 282 NHILYLYRSFNYKEIDPSLGHMIVTL-----VARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15179   220 YYIGISIDTFMLLEIIKQSCEMEQTVhkwisITEALAFFHCCLNPILYAFLGAKFKT 276
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
58-340 5.01e-19

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 86.03  E-value: 5.01e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  58 LLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSVFTLTAL 137
Cdd:cd15295    15 VLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPLYIPYTLTNRWDFGRGLCVFWLVIDYLLCTASVYNIVLI 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 138 SADRYRAIVNPMDMQTS-GVVLWTSLKAVGIWVVSVLLAVPEAVFSEvarigsSDNSSFTACIPypqtdELHPKIHSVLI 216
Cdd:cd15295    95 SYDRYQSVSNAVSYRNQqTATLRIVTQMVAVWVLAFLVHGPAILVSD------SWKTEDGECEP-----EFFSNWYILAI 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 217 FLVY-FLIPLVIISIYYYHIAKTLirsahnlpgeynehtKKQMETRKrLAKIVLVFVGCFVFCWFPNHILYLYRSFNYKE 295
Cdd:cd15295   164 TSVLeFLVPVILVAYFNTQIYWSL---------------WKRLRDRK-LAKSLAIILGTFAICWAPYSLFTIIRAACEKH 227
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1958642650 296 IDPSLGHmivtlVARVLSFSNSCVNPFALYLLSESFRKHFNSQLC 340
Cdd:cd15295   228 RGSPWYN-----FAFWLQWFNSFINPFLYPLCHKRFRKAFLKIFC 267
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
45-335 5.02e-19

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 86.40  E-value: 5.02e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMR---SVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPA 121
Cdd:cd15338     2 IMPSVFGVICFLGIIGNSIVIYTIVKKSKFRcqqTVPDIFIFNLSIVDLLFLLGMPFLIHQLLGNGVWHFGETMCTLITA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 122 IQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFsevARIGSSDNSSFTACI-- 199
Cdd:cd15338    82 LDTNSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLSITPVWMY---AGLMPLPDGSVGCALll 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 200 PYPQTDELHPKIHSvliFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPgeyneHTKKQMETRKrLAKIVLVFVGCFVFCW 279
Cdd:cd15338   159 PNPETDTYWFTLYQ---FFLAFALPLVVICVVYFKILQNMASTVAPLP-----QRSLRVRTKK-VTRMAVAICLAFFICW 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642650 280 FPNHILYLYrsfnYKEID-PSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15338   230 APFYILQLA----HLSIDrPSLAFLYAYNVAISMGYANSCINPFLYIMLSETFKRQF 282
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
52-321 6.49e-19

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 85.95  E-value: 6.49e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSV 131
Cdd:cd15384     9 VMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWAYTVAWLAGNTMCKLVKYLQVFGLYLST 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 132 FTLTALSADRYRAIVNPmdMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARigSSDNSSFTACIPYP-QTDELHPK 210
Cdd:cd15384    89 YITVLISLDRCVAILYP--MKRNQAPERVRRMVTVAWILSPIFSIPQAVIFHVER--GPFVEDFHQCVTYGfYTAEWQEQ 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 211 IHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSA---HNLPGEYNEHTKKQ----METRKRLAKIVLVFVGCFVFCWFPNH 283
Cdd:cd15384   165 LYNMLSLVFMFPIPLVIMVTCYVLIFITLSKSSrdfQGLEIYTRNRGPNRqrlfHKAKVKSLRMSAVIVTAFILCWTPYY 244
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1958642650 284 ILYLYRSF-NYKEIDPslghmIVTLVARVLSFSNSCVNP 321
Cdd:cd15384   245 VIMIWFLFfNPYPLND-----ILFDVIFFFGMSNSCVNP 278
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
46-334 1.43e-18

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 84.83  E-value: 1.43e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLT 125
Cdd:cd15968     3 LPICYSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALSLPLLIYNYAMRDRWLFGDFMCRLVRFLFYF 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 126 SVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFsevARIGSSDNssFTACIPYPQTD 205
Cdd:cd15968    83 NLYGSILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILIF---ARTGIIRN--RTVCYDLAPPA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 206 EL-HPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHtkkqmetRKRLAKIVLVFVGCFVFCWFPNHI 284
Cdd:cd15968   158 LFpHYVPYGMALTVSGFLLPFSIILWCYCLVVRTLCRTLGPAEPPAQAR-------RRKSIRTIVTVTLLFALCFLPFHI 230
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958642650 285 ---LYLYRSFNYKEIDPSLGHMIVTL-VARVLSFSNSCVNPFALYLLSESFRKH 334
Cdd:cd15968   231 trtIYLAVRVTPGVPCHVLEAVAACYkITRPLASANSVLNPLLYFLTKKKFGRR 284
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
3-335 2.11e-18

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 86.22  E-value: 2.11e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650   3 PRSLPNLSLPTEASESELEPEVWENDFLPDSD---GTTAELVI---RCVIPSL-------YLIIISVGLLGNIMLVKIfL 69
Cdd:PHA02638   45 PTEIPTSESPSPNSNSSSSSSSSSSSITYDYEyenNITYELINiknKCMYPSIseyikifYIIIFILGLFGNAAIIMI-L 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  70 TNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRyfFDEWVFGKLGCKLIPAIQLTSVGVSVFTLTALSADRYRAIVNPM 149
Cdd:PHA02638  124 FCKKIKTITDIYIFNLAISDLIFVIDFPFIIYNE--FDQWIFGDFMCKVISASYYIGFFSNMFLITLMSIDRYFAILYPI 201
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 150 DMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACIPYPQT---------DELHPKIHSVLIFLVY 220
Cdd:PHA02638  202 SFQKYRTFNIGIILCIISWILSLIITSPAYFIFEASNIIFSAQDSNETISNYQCTliedneknnISFLGRILQFEINILG 281
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 221 FLIPLVIISIYYYHIAKTLirsahnlpgeynEHTKKQMETRKrlAKIVLVFVGCFVFCWFPNHILYLYRS-FNYKEIDPS 299
Cdd:PHA02638  282 MFIPIIIFAFCYIKIILKL------------KQLKKSKKTKS--IIIVSIIIICSLICWIPLNIVILFATmYSFKGFNSI 347
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1958642650 300 LGHMIVTLV--------ARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:PHA02638  348 ISEHICGFIklgyammlAEAISLTHCCINPLIYTLIGENFRMHL 391
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
48-335 2.43e-18

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 84.20  E-value: 2.43e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  48 SLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIPAIQLTSV 127
Cdd:cd15155     5 AVYSVVFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDLLFVFT-LPFKIFYNFNRHWPFGDSLCKISGTAFLTNI 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVarigsSDNSSFTACIPYPQTDEL 207
Cdd:cd15155    84 YGSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTT-----NVSNTSTTCFEGFSKSIW 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 208 HPKIHSVLIFL--VYFLIPLVIISIYYYHIAKTLIRSAhnlpgeynehTKKQMET-RKRLAKIVLVFVGCFVFCWFP-NH 283
Cdd:cd15155   159 KTYLSKITIFIevVGFIIPLLLNLTCSSLVLRTLRKPA----------TLSQIGTnKEKVLKMILVHVAIFVVCFVPyNS 228
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958642650 284 ILYLYRSFNYKEI-DPSLGHMIVTL--VARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15155   229 ILFLYALVRSQAIaNCGVERFARTMypITLCLATLNCCFDPFVYYFTSESFQKSF 283
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
44-335 2.44e-18

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 84.82  E-value: 2.44e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  44 CVIpslYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDasryFFDEW-----VFGKLGCKL 118
Cdd:cd15358     4 CVT---YLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPLE----LYEMWsnypfLLGAGGCYF 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 119 IPAIQLTSVGVSVFTLTALSADRYRAIVNPmdMQTSGVVLWTSLKAV--GIWVVSVLLAVPEAVFS-----EVARIGSSD 191
Cdd:cd15358    77 KTLLFETVCFASILNVTALSVERYIAVVHP--LKAKYVVTRTHAKRVigAVWVVSILCSIPNTSLHgifqlTVPCRGPVP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 192 NSSftACIPypqtdeLHPKIHSVLIF----LVYFLIPLVIISIYYYHIAKTLIR--------SAHNLPGEYNEHTKKQME 259
Cdd:cd15358   155 DSA--TCML------VKPRWMYNLIIqittLLFFFLPMGTISVLYLLIGLQLKRekmllvleAKGSKAGDSYQHRRIQQE 226
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958642650 260 TRKR--LAKIVLVFVGCFVFCWFPNHILYLYRSFNYKEIDP-SLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15358   227 KRRRrqVTKMLFVLVVVFGICWAPFHTDRLMWSFISQWTGElHLAFQYVHIISGVFFYLSSAANPVLYNLMSTRFREMF 305
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
46-335 3.00e-18

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 84.50  E-value: 3.00e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDasryFFDEW-----VFGKLGCKLIP 120
Cdd:cd15133     3 VCLTYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLE----LYELWqnypfLLGSGGCYFKT 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 121 AIQLTSVGVSVFTLTALSADRYRAIVNPMdMQTSGVVLWTSLKAVGI-WVVSVLLAVPEAVFSEVARIGSSDNSSFTACI 199
Cdd:cd15133    79 FLFETVCLASILNVTALSVERYIAVVHPL-AARTCSTRPRVTRVLGCvWGVSMLCALPNTSLHGIKFLGSGVPASAQCTV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 200 PYPQTD-ELHPKIHSVLiflvYFLIPLVIISIYYYHIAKTL-------IRSAHNLPGEYNEHTKKQMETRKRLAKIVLVF 271
Cdd:cd15133   158 RKPQAIyNMIPQHTGHL----FFVLPMAVISVLYLLMALRLarergldATGAGSKIGTRTGQLLQHPRTRAQVTKMLFIL 233
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642650 272 VGCFVFCWFPNHILYLYRSFNYKEIDpsLGHMI---VTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15133   234 VVVFAICWAPFHIDRLMWSFISDWTD--NLHEVfqyVHIISGVFFYLSSAVNPILYNLMSTRFREMF 298
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
45-333 3.28e-18

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 83.86  E-value: 3.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15074     2 IIGIYLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNP-----MDMQTSGVVLwtslkaVGIWVVSVLLAVPeavfsEVARIGSSDNSSF-TAC 198
Cdd:cd15074    82 LFGCCSINTLTAISIYRYLKICHPpygpkLSRRHVCIVI------VAIWLYALFWAVA-----PLVGWGSYGPEPFgTSC 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 199 IP--YPQTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTlIRSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFV 276
Cdd:cd15074   151 SIdwTGASASVGGMSYIISIFIFCYLLPVLIIVFSYVKIIRK-VKSSRKRVAGFDSRSKRQHKIERKVTKVAVLICAGFL 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642650 277 FCWFPNHILYLYRSFNYKEIDPSLghmiVTLVARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15074   230 IAWTPYAVVSMWSAFGSPDSVPIL----ASILPALFAKSSCMYNPIIYLLFSSKFRQ 282
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
49-335 3.28e-18

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 84.14  E-value: 3.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDA----SRYFFdewVFGKLGCKLIPAIQL 124
Cdd:cd15357     6 VYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMPLEVyemwSNYPF---LFGPVGCYFKTALFE 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVP----EAVFSEVARIGSSDNSSFTACIP 200
Cdd:cd15357    83 TVCFASILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFSIPntsiHGIKLQYFPNGTLIPDSATCTVV 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 201 YPQTdeLHPKIHSVLIFLVYfLIPLVIISIYYYHIAKTLiRSAHNLpgEYNE-HTKKQMETRKRLAKIVLVFVGCFVFCW 279
Cdd:cd15357   163 KPLW--IYNLIIQITSLLFY-VLPMGVISVLYYLMGLKL-RGDKSL--EADEmNVNIQRPSRKSVTKMLFVLVLVFAICW 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642650 280 FPNHILYLYRSFNYKEIDPSLGHM-IVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15357   237 APFHVDRLFFSFVVEWTEPLANVFnLIHVVSGVFFYLSSAVNPIIYNLLSRRFRTAF 293
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
52-341 3.49e-18

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 83.44  E-value: 3.49e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVGLLGN-IMLVKIFLTNSTMRSVpNIFISNLAAGDLLLLLTCV-P---VDASRYFFDewvfGKLGCKLIPAIQLTS 126
Cdd:cd15196     9 TILVLALFGNsCVLLVLYRRRRKLSRM-HLFILHLSVADLLVALFNVlPqliWDITYRFYG----GDLLCRLVKYLQVVG 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 127 VGVSVFTLTALSADRYRAIVNPMD--MQTSGVVLWTSLKAvgiWVVSVLLAVPEAVFSEVARIGSSDNSSFTACIPypqt 204
Cdd:cd15196    84 MYASSYVLVATAIDRYIAICHPLSshRWTSRRVHLMVAIA---WVLSLLLSIPQLFIFSYQEVGSGVYDCWATFEP---- 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 dELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSahnlpgeynehtkkqmetRKRLAKIVLVFVGCFVFCWFPNHI 284
Cdd:cd15196   157 -PWGLRAYITWFTVAVFVVPLIILAFCYGRICYVVWRA------------------KIKTVKLTLVVVACYIVCWTPFFV 217
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642650 285 LYLYRSFNYkeiDPSLGHMIVTLVArVLSFSNSCVNPFaLYLlsesfrkHFNSQLCC 341
Cdd:cd15196   218 VQMWAAWDP---TAPIEGPAFVIIM-LLASLNSCTNPW-IYL-------AFSGNLRR 262
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
46-334 3.52e-18

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 83.69  E-value: 3.52e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLT 125
Cdd:cd15370     3 LPIVYIIVFVVGLPSNAMALWVFLFRTKKKHPAVIYMANLALADLLFVIWFPLKIAYHINGNNWIYGEALCKVLIGFFYG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 126 SVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLkAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACIPyPQTD 205
Cdd:cd15370    83 NMYCSILFMTCLSVQRYWVIVNPMSHSRKKANIAIGI-SLAIWLLILLVTIPLYLVKQTVFIPALDITTCHDVLP-EQLL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 206 ELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSahnlpgEYNEHTKKQmetRKRLAKIVLVFVGCFVFCWFPNHIL 285
Cdd:cd15370   161 VGDMFNYFLSLAIGVFLFPAFLTAVAYVLMIRALKSS------INDESIEKK---RKRAIKLIVTVLVMYLICFTPSNLL 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1958642650 286 YLYRSFNYKEIDPSLGHMIVtLVARVLSFSNSCVNPFALYLLSESFRKH 334
Cdd:cd15370   232 LVVHYFLLKNQGQSSVYAFY-ITALCLSTLNSCIDPFVYYFVSHDFRDH 279
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
51-335 4.35e-18

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 83.67  E-value: 4.35e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  51 LIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVS 130
Cdd:cd15209     8 IVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGLSVIGS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 131 VFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEavfsevARIGSSDNSSFTACIPYPQTDElhpK 210
Cdd:cd15209    88 IFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLTVLAVLPN------FFIGSLQYDPRIYSCTFAQTVS---T 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 211 IHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTKKQmETRKRLAKIVlVFVgCFVFCWFPNHILYLYRS 290
Cdd:cd15209   159 VYTITVVVIHFLLPLLIVSFCYLRIWVLVLQVRQRVKPDQRPKLKPA-DVRNFLTMFV-VFV-LFAVCWAPLNFIGLAVA 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1958642650 291 FNYKEIDPSLGHMIVtLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15209   236 INPKEMAPKIPEWLF-VASYFMAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
52-335 5.78e-18

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 83.02  E-value: 5.78e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSV 131
Cdd:cd15325     9 GFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 132 FTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVpeavfsevarigssdNSSFTACIPYPQtDELHPKI 211
Cdd:cd15325    89 MSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISI---------------GPLFGWKEPAPE-DETICQI 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 212 -----HSVLIFLVYFLIPLVIISIYYYHIAKTLIRsahnlpgeynehtkkqMETRKRLAKIVLVFVGCFVFCWFPNHILY 286
Cdd:cd15325   153 teepgYALFSALGSFYLPLAIILVMYCRVYVVALK----------------FSREKKAAKTLGIVVGCFVLCWLPFFLVM 216
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1958642650 287 LYRSFnYKEIDPSLGHMIVTLvarVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15325   217 PIGSI-FPAYKPSDTVFKITF---WLGYFNSCINPIIYPCSSQEFKKAF 261
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
51-332 7.72e-18

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 82.92  E-value: 7.72e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  51 LIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLtCVPVDASRYF-FDEWVFGKLGCKLIPAIQLTSVGV 129
Cdd:cd15132     8 LILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLILL-CLPFDLYRLWkSRPWIFGEFLCRLYHYISEGCTYA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 130 SVFTLTALSADRYRAIVNPMDMQTsgVVLWTSLKAV--GIWVVSVLLAVPEAVFSEVARIGSSDNSSFT-ACIPYPQTde 206
Cdd:cd15132    87 TILHITALSIERYLAICFPLRAKV--LVTRRRVKCViaALWAFALLSAGPFLFLVGVEQDNNIHPDDFSrECKHTPYA-- 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 207 LHPKIHSVLIFL--VYFLIPLVIISIYYYHIAKTLIRSAHNLPGeynEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNHI 284
Cdd:cd15132   163 VSSGLLGIMIWVttTYFFLPMLCLSFLYGFIGRKLWKSKNDLRG---PNAAARERSHRQTVRILAVVVLAFIICWLPFHI 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1958642650 285 LYLYRSfNYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFR 332
Cdd:cd15132   240 GRILFA-NTEDYRTMMFSQYFNIVAMQLFYLSASINPILYNLISRKYR 286
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
52-335 8.17e-18

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 82.27  E-value: 8.17e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSV 131
Cdd:cd15327     9 IFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCTASI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 132 FTLTALSADRYRAIVNPMDMQTsgvvLWTSLKAVgiwVVSVLLAVPEAVFSEVARIGSSDNssftacipyPQTDELHPKI 211
Cdd:cd15327    89 LSLCVISVDRYVGVKHSLKYPT----IMTERKAG---VILVLLWVSSMVISIGPLLGWKEP---------PPPDESICSI 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 212 -----HSVLIFLVYFLIPLVIISIYYYHIAKTLIRsahnlpgeynehtkkqMETRKRLAKIVLVFVGCFVFCWFPNHILY 286
Cdd:cd15327   153 teepgYALFSSLFSFYLPLMVILVMYFRVYVVALK----------------FSREKKAAKTLAIVVGVFILCWFPFFFVL 216
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1958642650 287 LYRSFnYKEIDPSLGhmiVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15327   217 PLGSF-FPALKPSEM---VFKVIFWLGYFNSCVNPIIYPCSSKEFKRAF 261
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
45-335 8.33e-18

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 82.37  E-value: 8.33e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGllGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15049     4 CIATGSLSLVTVG--GNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLALDY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVarIGSSDNSSFTACipypQT 204
Cdd:cd15049    82 VASNASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLWAPAILGWQY--FVGERTVPDGQC----YI 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSahnlpgeynehtkkqmetrKRLAKIVLVFVGCFVFCWFPNHI 284
Cdd:cd15049   156 QFLDDPAITFGTAIAAFYLPVLVMTILYWRIYRETARE-------------------RKAARTLSAILLAFIITWTPYNI 216
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 285 LYLYRSFNYKEIDPSLGHmivtlVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15049   217 LVLVSTFCAKCIPDTLWS-----FGYWLCYINSTINPFCYALCNKTFRKTF 262
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
45-335 1.04e-17

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 82.02  E-value: 1.04e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15061     1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAV--FSEVARIGSSdnssftACIPYp 202
Cdd:cd15061    81 LLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVgpSWHGRRGLGS------CYYTY- 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 203 qtdELHPKIHSVlifLVYFLIPLVIISIYYYHIAKTLirsahnlpgeynehtkkqmETRKRLAKIVLVFVGCFVFCWFPN 282
Cdd:cd15061   154 ---DKGYRIYSS---MGSFFLPLLLMLFVYLRIFRVI-------------------AKERKTAKTLAIVVGCFIVCWLPF 208
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 283 HILYLYRSFNYKEIDPSLgHMIVTLvarvLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15061   209 FIMYLIEPFCDCQFSEAL-STAFTW----LGYFNSVINPFIYAFYNKDFRRAF 256
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
49-335 1.47e-17

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 82.48  E-value: 1.47e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVgLLGNIMLVKIFLTNSTMRS-VPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLgCKLIPAIQLTSV 127
Cdd:cd15057     7 LYLLVLLT-LLGNALVIAAVLRFRHLRSkVTNYFIVSLAVSDLLVAILVMPWAAVNEVAGYWPFGSF-CDVWVSFDIMCS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLA-VPeaVFSEVARIGSSDNSSFTACIPyPQTDE 206
Cdd:cd15057    85 TASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISfIP--VQLGWHRADDTSEALALYADP-CQCDS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 207 LHPKIHSVLIFLVYFLIPLVIISIYY---YHIAKTLIR--SAHNLPGEYNEHTKKQMETR----KRLAKIVLVFVGCFVF 277
Cdd:cd15057   162 SLNRTYAISSSLISFYIPVAIMIVTYtriYRIARRQIRriAALERAAQESTNPDSSLRSSlrreTKALKTLSIIMGVFVC 241
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958642650 278 CWFPNHILYLYRSF------NYKEIDPSLGHMIVTlvarvLSFSNSCVNPFaLYLLSESFRKHF 335
Cdd:cd15057   242 CWLPFFILNCVLPFcdlrtaQFPCVPDTTFIVFVW-----LGWANSSLNPI-IYAFNADFRKAF 299
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
45-335 1.79e-17

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 81.88  E-value: 1.79e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15401     2 VLAGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLMG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVfsevarIGSSDNSSFTACIPYPQT 204
Cdd:cd15401    82 LSVIGSVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWVLTLAAIVPNFF------VGSLQYDPRIYSCTFAQT 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DElhpKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTkKQMETRKRLAKIVlVFVgCFVFCWFPNHI 284
Cdd:cd15401   156 VS---SSYTITVVVVHFIVPLSIVTFCYLRIWVLVIQVKHRVRQDSKQKL-KANDIRNFLTMFV-VFV-LFAVCWGPLNF 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 285 LYLYRSFNYKEIDPSLGHMIVTLvARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15401   230 IGLAVAINPLKVAPKIPEWLFVL-SYFMAYFNSCLNAVIYGVLNQNFRKEY 279
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
49-333 1.95e-17

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 81.98  E-value: 1.95e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISV-GLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTC-VPVDASRYFFDEWVFGKLGCKLIPAIQLTS 126
Cdd:cd15337     5 IYIAIVGIlGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNgFPLKTISSFNKKWIWGKVACELYGFAGGIF 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 127 VGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPeAVFSevarIGSSDNSSF-TACIPYPQTD 205
Cdd:cd15337    85 GFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIP-PFFG----WGRYVPEGFqTSCTFDYLSR 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 206 ELHPKIHSVLIFLVYFLIPLVIISIYYYHI-------AKTLIRSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFVFC 278
Cdd:cd15337   160 DLNNRLFILGLFIFGFLCPLLIIIFCYVNIiravrnhEKEMTQTAKSGMGKDTEKNDARKKAEIRIAKVAIILISLFLLS 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642650 279 WFPNHILYLYRSFNYKE-IDPSLGHMIVtLVARVLSFSNSCVnpfalYLLSE-SFRK 333
Cdd:cd15337   240 WTPYAVVALLGQFGPAYwITPYVSELPV-MFAKASAIYNPII-----YALSHpKFRA 290
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
52-341 2.08e-17

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 81.78  E-value: 2.08e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLL-TCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVS 130
Cdd:cd15198     9 VILVAGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGgTALSQIIWELLGDRWMAGDVACRLLKLLQASARGAS 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 131 VFTLTALSADRYRAIVNPmdmQTSGVVLWtSLKAVGiWVVSVLLAVPEA-VFSEVARIGSS---DNSSFTACIPYPQTdE 206
Cdd:cd15198    89 ANLVVLLALDRHQAIRAP---LGQPLRAW-KLAALG-WLLALLLALPQAyVFRVDFPDDPAsawPGHTLCRGIFAPLP-R 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 207 LHPKIHSVLIFLVYFLIPLVIISIYYYHI-AKTLIRSAHNLPGEYNEHTKKQMETRKRLA-----------KIVLVFVGC 274
Cdd:cd15198   163 WHLQVYATYEAVVGFVAPVVILGVCYGRLlLKWWERANQAPGAKKPWKKPSKSHLRATAPsalprakvktlKMTLVIALL 242
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642650 275 FVFCWFPNHILYLYRSFNYKEIDPSlghmIVTLVARVLSFSNSCVNPFaLYLLsesfrkhFNSQLCC 341
Cdd:cd15198   243 FVGCSLPYFIAELAAAFGSGDWEPE----KVAAALGVMAVANSATNPF-VFLF-------FNAGDCR 297
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
52-335 2.09e-17

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 81.22  E-value: 2.09e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSV 131
Cdd:cd15064     9 LIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLDVTCCTASI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 132 FTLTALSADRYRAIVNPMDM---QTSGvvlwTSLKAVGI-WVVSVLLAVPEAVF--------SEVARIgsSDNSSFTaci 199
Cdd:cd15064    89 LHLCVIALDRYWAITDAVEYahkRTPK----RAAVMIALvWTLSICISLPPLFGwrtpdsedPSECLI--SQDIGYT--- 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 200 pypqtdelhpkIHSVlifLVYFLIPLVIISIYYYHIaktlirsahnlpgeYNEHTKKQmetrkRLAKIVLVFVGCFVFCW 279
Cdd:cd15064   160 -----------IFST---FGAFYIPLLLMLILYWKI--------------YRAAARER-----KAAKTLGIILGAFIVCW 206
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 280 FPNHILYLYRSFNYKEIDPSLGHMIVTLvarvLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15064   207 LPFFLVALIVPLCSHCWIPLALKSFFLW----LGYFNSLINPLIYTFFNKDFRKAF 258
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
45-333 2.27e-17

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 81.34  E-value: 2.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDlLLLLTCVPVDASRYFFDE-WVFGKLGCKLIPAIQ 123
Cdd:cd14991     2 ILPPLLILEFVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLAD-FLLLICLPFRIDYYLRGEhWIFGEAWCRVNLFML 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNP---MDMQTSGVVLWTslkAVGIWVVSVLLAVPEAVFSEVARigssdNSSFTACIP 200
Cdd:cd14991    81 SVNRSASIAFLTAVALDRYFKVVHPhhrVNRMSVKAAAGV---AGLLWALVLLLTLPLLLSTLLTV-----NSNKSSCHS 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 201 Y--PQTDELHPKIHSVLiFLVYFLIPLVIISIYYYHIAKTLirsahNLPGEYNEHTKKQMETRkrlakIVLVFVGCFVFC 278
Cdd:cd14991   153 FssYTKPSLSIRWHNAL-FLLEFFLPLGLIVFCSVRIACNL-----RIRQSLGKQARVQRAIR-----LVFLVVIVFVLC 221
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958642650 279 WFPNHILYLYRSF----NYKEIDPSLGHMIVTLVArvLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd14991   222 FLPSIIAGLLALVfknlGSCRCLNSVAQLFHISLA--FTYLNSALDPVIYCFSSPWFRN 278
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
50-332 2.78e-17

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 80.96  E-value: 2.78e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  50 YLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDAsRYFFDEWVFGKLGCKLIPAIQLTSVGV 129
Cdd:cd15923     7 YIPTFVLGLLLNILALWVFCWRLKKWTETNIYMTNLAVADLLLLIS-LPFKM-HSYRRESAGLQKLCNFVLSLYYINMYV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 130 SVFTLTALSADRYRAIVNPMDMQTsgvvLWTSLKAVG----IWVVSVLLAVPEAVFsevariGSSDNSSFTacipYPQTD 205
Cdd:cd15923    85 SIFTITAISVDRYVAIRYPLRARE----LRSPRKAAVvcavIWVLVVTISIPYFLL------DSSNEKTMC----FQRTK 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 206 ELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPgeynehtkkQMETRKRLAKIVLVFVGCFVFCWFPNHIL 285
Cdd:cd15923   151 QTESLKVFLLLEIFGFLLPLIIMTFCSARVIHTLQKRLDDVG---------SRSETKQCIRVIMANLIVFIVCFLPVHVG 221
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1958642650 286 YLYRSFNYKEIDPSLGHMIVTL--VARVLSFSNSCVNPFALYLLSESFR 332
Cdd:cd15923   222 FFVKFIVGKSYSCDSKLIIHFFlqSAFCLSDMNCCLDAFCYYFATKEFR 270
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
49-335 3.04e-17

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 80.94  E-value: 3.04e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIIS-VGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSV 127
Cdd:cd15050     5 IALSTISlITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVAS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSftacipypqtDEL 207
Cdd:cd15050    85 TASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVIPILGWHHFARGGERVVLE----------DKC 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 208 HPKIHSVLIFLVY-----FLIPLVIISIYYYHIAKTLIRsahnlpgeynehtkkqmetRKRLAKIVLVFVGCFVFCWFPN 282
Cdd:cd15050   155 ETDFHDVTWFKVLtailnFYIPSLLMLWFYAKIFKAVNR-------------------ERKAAKQLGFIMAAFILCWIPY 215
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 283 HILYLYRSFNYKEIDPSLgHMIVTLvarvLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15050   216 FILFMVIAFCKNCCNENL-HMFTIW----LGYINSTLNPFIYPLCNENFKKTF 263
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
49-335 3.51e-17

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 80.91  E-value: 3.51e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVkiFLTNSTM-RSVPNIFISNLAAGDLLLLLTcVPVDASRYFFD-EWVFGKLGCKLIPAIQLTS 126
Cdd:cd15114     6 LYAVVFLVGVPGNALVA--WVTGFEAkRSVNAVWFLNLAVADLLCCLS-LPILAVPIAQDgHWPFGAAACKLLPSLILLN 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 127 VGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNssfTACIPYPQTDE 206
Cdd:cd15114    83 MYASVLLLTAISADRCLLVLRPVWCQNHRRARLAWIACGAAWLLALLLTVPSFIYRRIHQEHFPEK---TVCVVDYGGST 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 207 LHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNlpgeynehtkkqmETRKRLAKIVLVFVGCFVfCWFPNHILY 286
Cdd:cd15114   160 GVEWAVAIIRFLLGFLGPLVVIASCHGVLLVRTWSRRRQ-------------KSRRTLKVVTAVVVGFFL-CWTPYHVVG 225
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 287 LYRSFNykeiDPSLGHMIVTLVARVLSFS----NSCVNPFALYLLSESFRKHF 335
Cdd:cd15114   226 LIIAAS----APNSRLLANALKADPLTVSlayiNSCLNPIIYVVAGRGFRKSL 274
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
49-335 3.75e-17

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 81.14  E-value: 3.75e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVP--VDASRYFFDEWvfgkLGCKLIPAIQLTS 126
Cdd:cd15068     6 VELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPfaITISTGFCAAC----HGCLFIACFVLVL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 127 VGVSVFTLTALSADRYRAIVNPMDMQTsgvvLWTSLKAVGI----WVVSVLLAVPEAVFSEVARIGSSDNSSFTACiPYP 202
Cdd:cd15068    82 TQSSIFSLLAIAIDRYIAIRIPLRYNG----LVTGTRAKGIiaicWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGC-GEG 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 203 QTDELHPKIhSVLIFLVYF------LIPLVIISIYYYHI---AKTLIRSAHN--LPGEYNEHT-KKQMETRKRLAkivlV 270
Cdd:cd15068   157 QVACLFEDV-VPMNYMVYFnffacvLVPLLLMLGVYLRIflaARRQLKQMESqpLPGERARSTlQKEVHAAKSLA----I 231
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958642650 271 FVGCFVFCWFPNHILYLYRSFNYKEIDPSLghmIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15068   232 IVGLFALCWLPLHIINCFTFFCPDCSHAPL---WLMYLAIVLSHTNSVVNPFIYAYRIREFRQTF 293
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
41-321 4.06e-17

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 80.60  E-value: 4.06e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  41 VIRCVIPSLYLIIisvGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIP 120
Cdd:cd14975     1 VLGCTLLSLAFAI---GLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLT-LPVWIYFLATGTWDFGLAACKGCV 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 121 AIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTsgvvlWTSLKAV-----GIWVVSVLLAVPEAVFSEVarIGSSDNSsf 195
Cdd:cd14975    77 YVCAVSMYASVFLITLMSLERFLAVSRPFVSQG-----WRAKALAhkvlaIIWLLAVLLATPVIAFRHV--EETVENG-- 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 196 tACIPYPQTDElHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHnlpgeynehtkkqmETRKRLAKIVLVFVGCF 275
Cdd:cd14975   148 -MCKYRHYSDG-QLVFHLLLETVVGFAVPFTAVVLCYSCLLRRLRRRRF--------------RRRRRTGRLIASVVVAF 211
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958642650 276 VFCWFPNHILYLYRSFNY----KEIDPSLGHM--IVTLVARVLSFSNSCVNP 321
Cdd:cd14975   212 AACWLPYHVGNLLEVVSEliggSKMAGTLGKVaeAGRPIAGALAFLSSSINP 263
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
45-335 5.63e-17

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 80.28  E-value: 5.63e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15400     2 ALSSVLIFTTVVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKVSGFVMG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVfsevarIGSSDNSSFTACIPYPQT 204
Cdd:cd15400    82 LSVIGSIFNITGIAINRYCYICHSFAYDKLYSRWNTLLYVCLIWALTVVAIVPNFF------VGSLEYDPRIYSCTFVQT 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHpkiHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTkKQMETRKRLAKIVlVFVgCFVFCWFPNHI 284
Cdd:cd15400   156 ASSS---YTIAVVVIHFIVPITVVSFCYLRIWVLVIQVRRKVKSESKPRL-KPSDFRNFLTMFV-VFV-IFAICWAPLNL 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 285 LYLYRSFNYKEIDPSLGHMIVtLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15400   230 IGLAVAINPQEMAPKVPEWLF-VVSYFMAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
49-332 6.15e-17

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 79.72  E-value: 6.15e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd15213     6 LMILMIFVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLYWFFVL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPMDMQTSGVvlwTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDnssfTACIpYPQTDELH 208
Cdd:cd15213    86 EGVAILLIISVDRYLIIVQRQDKLNPHR---AKILIAVSWVLSFCVSFPPLVGWGKYEFPPRA----PQCV-LGYTESPA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 209 PKIHSVLIFLVYFLIPLVIISIYYYHIAKTlIRSahnlpgeynehtkkqMETRKrLAKIVLVFVGcFVFCWFPNHILYLY 288
Cdd:cd15213   158 DRIYVVLLLVAVFFIPFLIMLYSYFCILNT-VRS---------------FKTRA-FTTILILFIG-FSVCWLPYTVYSLL 219
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1958642650 289 RSFNykeiDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFR 332
Cdd:cd15213   220 SVFS----RYSSSFYVISTCLLWLSYLKSAFNPVIYCWRIKKFR 259
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
45-333 8.29e-17

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 79.79  E-value: 8.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFD-EWVFGKLGCKLIPAIQ 123
Cdd:cd15158     2 VYSTLYSVITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLCVCT-LPLRVVYYVHKgQWLFGDFLCRISSYAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFsevariGSSDNSS-FTACIPYP 202
Cdd:cd15158    81 YVNLYCSIYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFVTLTSSPFLMS------GSHDTETnKTKCFEPP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 203 QTDELHPKihsvLIFLVY------FLIPLVIISIYYYHIAKTLIRSahnlpgeyNEHTKKQMETRKRLAKIVLVFVGCFV 276
Cdd:cd15158   155 QSNQQLTK----LLVLNYislvvgFIIPFLVILICYAMIIRTLLKN--------TMKARKQQSSRKKAIRMIIIVLLAFL 222
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958642650 277 FCWFPNHI---LYLYRSFNYKEIDPSLGHM----IVTLvarVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15158   223 VSFMPYHIqrtIHLHFLSRKDSTCEEVLYMqksvVITL---CLAAANCCFDPLLYFFSGENFRR 283
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
45-335 1.18e-16

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 79.53  E-value: 1.18e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15183     2 LLPPLYSLVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDLVFLFT-LPFWIDYKLKDDWIFGDAMCKFLSGFYY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSftACIPYPQT 204
Cdd:cd15183    81 LGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPCLYFFKSQWEFTHHTCS--AHFPRKSL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHpKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRsahnlpgeynehtkKQMETRKRLAKIVLVFVGCFVFCWFPNHI 284
Cdd:cd15183   159 IRWK-RFQALKLNLLGLILPLLVMIICYTGIINILLR--------------RPNEKKAKAVRLIFVITLLFFLLWTPYNL 223
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958642650 285 LYLYRSFN----YKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15183   224 AAFVSAFQdvlfTPSCEQSQQLDLALQVTEVIAYTHCCVNPVIYVFVGERFRKYL 278
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
51-335 1.40e-16

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 79.56  E-value: 1.40e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  51 LIIISVgLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVS 130
Cdd:cd15958     9 LIVLLI-VAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGRWLYGSFFCELWTSVDVLCVTAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 131 VFTLTALSADRYRAIVNPMDMQTsgvvLWTSLKAVGI----WVVSVLLAvpeavFSEVARIGSSDNSSF-TACIPYPQ-T 204
Cdd:cd15958    88 IETLCVIAIDRYLAITSPFRYQS----LLTRARAKGIvctvWAISALVS-----FLPIMMHWWRDEDDQaLKCYEDPGcC 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHPKIHSVLIFLVYFLIPLVIISIYY---YHIAKTLIRSAHNLPGEY-NEHTKKQMETRKRLAKIVL----------- 269
Cdd:cd15958   159 DFVTNRAYAIASSIISFYIPLLIMIFVYlrvYREAKKQIKKIDKCEGRFhNTLTGLGRKCKRRPSRILAlreqkalktlg 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 270 VFVGCFVFCWFPNHILYLYRSFNYKEIDPSLghmivTLVARVLSFSNSCVNPFaLYLLSESFRKHF 335
Cdd:cd15958   239 IIMGVFTLCWLPFFLVNVVNVFNRELVPDWL-----FVFFNWLGYANSAFNPI-IYCRSPDFRKAF 298
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
46-334 1.97e-16

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 78.67  E-value: 1.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTN-STMRSVPNIFISNLAAGDLLLLLTcVPVDASrYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15188     3 LPVFYTLVFLLGLAGNLLLFVVLLLYvPKKKKMTEVYLLNLAVSDLLFLVT-LPFWAM-YVAWHWVFGSFLCKFVSTLYT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARigsSDNSSFTACIPYPQT 204
Cdd:cd15188    81 INFYSGIFFVSCMSLDKYLEIVHAQSPHRLRTRRKSLLVLVAVWVLSIALSVPDMVFVQTHH---TNNGVWVCHADYGGH 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSahnlpgeynehtkkQMETRKRLAKIVLVFVGCFVFCWFP-NH 283
Cdd:cd15188   158 HTIWKLVFQFQQNLLGFLFPLLAMVFFYSRIACVLTRL--------------RPPGQGRALRFVAALVVVFFVLWFPyNL 223
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 284 ILYLYRSFNYK-----EIDPSLGHMIvtLVARVLSFSNSCVNPFALYLLSESFRKH 334
Cdd:cd15188   224 TLFLHSLQDLHvigncERSRHLDYAL--QVTESLAFVHCCLNPLLYAFVSKRFRLY 277
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
46-335 2.61e-16

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 78.58  E-value: 2.61e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLlTCVPVDASRYFFDE-WVFGKLGCKLIPAIQL 124
Cdd:cd15375     3 LPVMYSIIFIVGFPGNIIAIFVYLFKMRPWKSSTIIMLNLALTDLLYV-TSLPFLIYYYINGEsWIFGEFMCKFIRFIFH 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFsevarIGSSDNSSFTACIPYPQT 204
Cdd:cd15375    82 FNLYGSILFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVACAVVWVISLAEVSPMTFL-----ITTKEKNNRTICLDFTSS 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHP-KIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNlpgeynehtkkQMETRKRLAKIVLVFVGCFVFCWFPNH 283
Cdd:cd15375   157 DNLNTiWWYNWILTVLGFLLPLVIVTLCYTRIIYTLAKGPHT-----------GSASKQKARRLIILILLVFYVCFLPFH 225
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 284 ILYLYR-SFNYKEIDPSLGHMI--VTLVARVLSFSNSCVNpFALYLLS-ESFRKHF 335
Cdd:cd15375   226 ILRVVRiETRLPPVSCCLKHQVhaIYIITRPLAALNTFGN-LLLYVVSgDNFQQAF 280
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
106-335 3.39e-16

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 78.28  E-value: 3.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 106 FDEWVFGKLGCKLIPAIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEV- 184
Cdd:cd15120    62 DNHWAFGTVLCKVLNSTLSVGMFTSVFLLTAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILLSIPYLAFRETr 141
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 185 ----ARIGSSDNSSFTACIPYPQTDELHPKIHSVLI---FLVYFLIPLVIISIYYYHIAktlirsahnlpgeyNEHTKKQ 257
Cdd:cd15120   142 ldekGKTICQNNYALSTNWESAEVQASRQWIHVAMFvfrFLLGFLLPFLIITFCYVRMA--------------LKMKERG 207
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958642650 258 METRKRLAKIVLVFVGCFVFCWFPNHilyLYRSFNYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15120   208 LARSSKPFKVMFTAVVSFFVCWLPYH---LHSGLVLTRGRPPSLTDITLLLTVGTTCFNTCFTPVLYLFVGENFKKVL 282
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
45-341 5.19e-16

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 77.30  E-value: 5.19e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15299     5 LIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDY 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVArIGSSDNSSFTACIPYpqt 204
Cdd:cd15299    85 VASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYF-VGKRTVPPDECFIQF--- 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 deLHPKIHSVLIFLVYFLIPLVIISIYYYHIAKtlirsahnlpgeyneHTKKQMETRKRLAKIVLVfvgcFVFCWFPNHI 284
Cdd:cd15299   161 --LSEPIITFGTAIAAFYLPVTIMTILYWRIYK---------------ETIKEKKAAQTLSAILLA----FIITWTPYNI 219
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642650 285 LYLYRSFNYKEIDPSLGHmivtlVARVLSFSNSCVNPFALYLLSESFRKHFNSQLCC 341
Cdd:cd15299   220 MVLVNTFCDSCIPKTYWN-----LGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLC 271
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
52-335 7.12e-16

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 77.30  E-value: 7.12e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVG-LLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVP--VDAS----RYFFdewvfgklGCKLIPAIQL 124
Cdd:cd14968     8 VLIAVLsVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPlaILISlglpTNFH--------GCLFMACLVL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQtSGVVLWTSLKAVGI-WVVSVLLA-VPEA-VFSEVARIGSSDNSS----FTA 197
Cdd:cd14968    80 VLTQSSIFSLLAIAIDRYLAIKIPLRYK-SLVTGRRAWGAIAVcWVLSFLVGlTPMFgWNNGAPLESGCGEGGiqclFEE 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 198 CIPYPqtdelhpkihsvliFLVYF------LIPLVIISIYYYHIAKTLIRSAHNLPGEY-NEHTKKQMETRKRLAKIVLV 270
Cdd:cd14968   159 VIPMD--------------YMVYFnffacvLVPLLIMLVIYLRIFRVIRKQLRQIESLLrSRRSRSTLQKEVKAAKSLAI 224
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642650 271 FVGCFVFCWFPNHILYLYRSFNykeidPSLG-HMIVTLVARVLSFSNSCVNPFaLYLLS-ESFRKHF 335
Cdd:cd14968   225 ILFLFALCWLPLHIINCITLFC-----PECKvPKILTYIAILLSHANSAVNPI-VYAYRiRKFRQTF 285
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
45-335 7.35e-16

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 77.01  E-value: 7.35e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLlTCVPVDASRYFFD-EWVFGKLGCKLIPAIQ 123
Cdd:cd15159     2 LLPLFYSLILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILFT-LALPGRIAYYALGfDWPFGDWLCRLTALLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPeavfsEVARIGSSDNSSFTACIPYPQ 203
Cdd:cd15159    81 YINTYAGVNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFLQTLP-----LLFMPMTKEMGGRITCMEYPN 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELhPKIHSVLIF--LVYFLIPLVIISIYYYHIAKTLIRSAHNlpgeyNEHTKKQMETRKRLAKIVLVFVgCFVFCWFP 281
Cdd:cd15159   156 FEKI-KRLPLILLGacVIGFGVPVGIILFCYSQITLKLCRTAKE-----NPLTEKSGHHKKACNVILLVLL-VFVVCFSP 228
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958642650 282 NH---ILYLYRSFNYKEIDPSLGHMIVTLVARV-LSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15159   229 YHlniIQFMIRKLLYQPSCSELKAFKISLQITVcLMNLNCCLDPFIYFFACKGYKKKV 286
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
53-335 1.01e-15

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 76.37  E-value: 1.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  53 IISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSVF 132
Cdd:cd15062    10 FILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTASIM 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 133 TLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAV-PEAVFSEVArigssdNSSFTACipypQTDElhPKI 211
Cdd:cd15062    90 SLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIgPLLGWKEPA------PADEQAC----GVNE--EPG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 212 HSVLIFLVYFLIPLVIISIYYYHIAKTLIRsahnlpgeynehtkkqMETRKRLAKIVLVFVGCFVFCWFPNHILYLYRSF 291
Cdd:cd15062   158 YVLFSSLGSFYLPLAIILVMYCRVYVVAFK----------------FSREKKAAKTLGIVVGAFVLCWFPFFVVLPLGSL 221
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1958642650 292 nYKEIDPSLGhmiVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15062   222 -FSTLKPPEP---VFKVVFWLGYFNSCLNPIIYPCSSREFKRAF 261
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
45-335 1.12e-15

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 76.73  E-value: 1.12e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLtCVPVDASRYFF-DEWVFGKLGCKLIPAIQ 123
Cdd:cd15368     2 ILPVVYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLAC-FLPFQIVYHIQrNHWIFGKPLCNVVTVLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDnssFTACIPYPQ 203
Cdd:cd15368    81 YANMYSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTALSPLERTDLTYYVKELN---ITTCFDVLK 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELHPKIHSVL----IFLVYFLIPLVIISIYYYHIAKTLIRSAhnlpgeyNEHTKKQMETRKRLAKIVLVfvgCFVFCW 279
Cdd:cd15368   158 WTMLPNIAAWAAflftLFILLFLIPFIITVYCYVLIILKLVQTS-------ERYGREQKRRAIYLALIVLL---VFITCF 227
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 280 FPNHILYLYRSFNYKEIDPSLGHmiVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15368   228 APNNFILLAHMVSRLFYGKSLYH--AYKLTLSLSCLNSCLDPFIYYFASKEFRKKL 281
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
45-335 1.81e-15

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 75.79  E-value: 1.81e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYL-IIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQ 123
Cdd:cd15330     1 IITSLFLgTLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARigssDNSSFTACIPypq 203
Cdd:cd15330    81 VLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPMLGWRTPE----DRSDPDACTI--- 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 tdelhPKIHSVLIFLVY--FLIPLVIISIYYYHIAKTLIRsahnlpgeynehtkkqmetRKRLAKIVLVFVGCFVFCWFP 281
Cdd:cd15330   154 -----SKDPGYTIYSTFgaFYIPLILMLVLYGRIFKAAAR-------------------ERKTVKTLGIIMGTFILCWLP 209
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 282 NHILYLYRSFNykeidPSLGHMIVTLVARV--LSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15330   210 FFIVALVLPFC-----ESTCHMPELLGAIInwLGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
51-321 1.85e-15

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 76.00  E-value: 1.85e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  51 LIIISVGLLGNIMLVKIFL--TNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd15122     8 LLAALLGLPGNGFIIWSILwkMKARGRSVTCILILNLAVADGAVLLL-TPFFITFLTRKTWPFGQAVCKAVYYLCCLSMY 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVArigSSDNSSFTACIPYPQTDeLH 208
Cdd:cd15122    87 ASIFIIGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALPAFVYRHVW---KDEGMNDRICEPCHASR-GH 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 209 PKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNlpgeynehtkkqmeTRKRLAKIVLVFVGCFVFCWFPNHILYLY 288
Cdd:cd15122   163 AIFHYTFETLVAFVLPFGVILFSYSVILVRLKGARFR--------------RRARVEKLIAAIVVAFALLWVPYHVVNLL 228
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1958642650 289 RSFN---YKEIDPSLGHMIVTLVARV--LSFSNSCVNP 321
Cdd:cd15122   229 QVVAnlaPGEVLEKLGGAAKAARAGAtaLAFFSSSVNP 266
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
47-333 2.14e-15

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 75.58  E-value: 2.14e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  47 PSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDeWVFGKLGCKLIPAIQLTS 126
Cdd:cd15177     4 PCVYLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLLT-LPFAAAETLQG-WIFGNAMCKLIQGLYAIN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 127 VGVSVFTLTALSADRYRAIVN--PMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARigssdNSSFTAC-IPYPQ 203
Cdd:cd15177    82 FYSGFLFLTCISVDRYVVIVRatSAHRLRPKTLFYSVLTSLIVWLLSILFALPQLIYSRVEN-----RSELSSCrMIFPE 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELHPKIHSVLIFLVY-FLIPLVIISIYYYHIAKTLIRSahnlpgeynehtkKQMETRKRLaKIVLVFVGCFVFCWFPN 282
Cdd:cd15177   157 VVSRTVKGATALTQVVLgFAIPLIVMAVCYAAIGRTLLAA-------------RGWERHRAL-RVIAALVVAFVLFQLPY 222
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 283 HILYLYRS---FNYKEI--DPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15177   223 SVVLLLDTadlLATLELscSQSKRKDIALLVTSGLAYVRCCLNPLLYAFVGVRFRR 278
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
50-335 2.50e-15

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 75.57  E-value: 2.50e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  50 YLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIPAI-QLTSVG 128
Cdd:cd15154     7 YSLLFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTLS-LPLRIYYYANHYWPFGNFLCQFSGSIfQMNMYG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFtLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACIPYPQTD--E 206
Cdd:cd15154    86 SCLF-LMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVWALILGGSVPAAIVHSSSDCLLHGEKVYRCFESFSDNDwkG 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 207 LHPKIhsVLIFLVYFLIPLVIISIYYYHIAKTLIRSahnlpgeynehTKKQMETRKRLAKIVLVFVGCFVFCWFP-NHIL 285
Cdd:cd15154   165 LLPLV--VLAEILGFLLPLAAVLYCSCRIFVELCRT-----------QEPQQGRRRKTVRLLLVNLVIFLICFVPyNTTL 231
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 286 YLYRSFNYKEID------PSLGHMIVTLVarVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15154   232 AVYGLLRANLVEdtwnikDTLRKVLSVTV--LLASTNCALDPLVYYFSTEGFRNTL 285
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
46-328 7.17e-15

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 74.41  E-value: 7.17e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLT 125
Cdd:cd16001     3 LPVTYSVVFVLGLPLNGTVLWLSWCRTKRWTCSTIYLVNLAVADLLYVCSLPLLIVNYAMRDRWPFGDFLCKLVRFLFYT 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 126 SVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFsevARIGSSDNSsfTACIPYPQTD 205
Cdd:cd16001    83 NLYGSILFLTCISVHRFLGVCYPIRSLAYRTRRLAVIGSAATWILVVLQLLPTLVY---ARTGSINNR--TVCYDLTSPD 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 206 ELHPK-IHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSahnlpgeyNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNHI 284
Cdd:cd16001   158 NFGNYfPYGMVLTVTGFLIPFLIILLCYCLMIKSLIRS--------EEAAGVGKAARAKSIRTILLVCGLFALCFVPFHI 229
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1958642650 285 ---LYLYRSFNYKEIDPSL-GHMIVTLVARVLSFSNSCVNPFaLYLLS 328
Cdd:cd16001   230 trtIYLFVRVYLVQDCPLLqFVSLAYKIWRPLVSFNSCINPL-LYFLS 276
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
49-335 9.69e-15

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 73.53  E-value: 9.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFD-EWVFGKLGCKLIPAIQLTSV 127
Cdd:cd15053     6 FLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNGgKWYLGPILCDIYIAMDVMCS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPeAVFSevarIGSSDNSSFTACIPYPQTDEL 207
Cdd:cd15053    86 TASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACP-LLFG----LNNVPYRDPEECRFYNPDFII 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 208 HPKIHSvliflvyFLIPLVIISIYYYHIAKTLIRsahnlpgeynehtkkqmetRKRLAKIVLVFVGCFVFCWFP---NHI 284
Cdd:cd15053   161 YSSISS-------FYIPCIVMLLLYYRIFRALRR-------------------EKKATKTLAIVLGVFLFCWLPfftLNI 214
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 285 LYLYrSFNYKEIDPSLGHMIVTLVArVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15053   215 LNAI-CPKLQNQSCHVGPALFSLTT-WLGYVNSFLNPIIYTIFNIEFRKAF 263
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
52-335 1.05e-14

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 74.17  E-value: 1.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSV 131
Cdd:cd15959     9 LAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVTASI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 132 FTLTALSADRYRAIVNPM--DMQTSGVVLWTSLkaVGIWVVSVLLAVPeAVFSEVARIGSsdNSSFTACIPYPQ-TDELH 208
Cdd:cd15959    89 ETLCAIAVDRYLAITNPLryEALVTKRRARTAV--CLVWAISAAISFL-PIMNQWWRDGA--DEEAQRCYDNPRcCDFVT 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 209 PKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAH-------NLPGEYNEHTKKQMETRKRLAKIVL-----------V 270
Cdd:cd15959   164 NMPYAIVSSTVSFYVPLLVMIFVYVRVFVVATRQVRlirkdkvRFPPEESPPAESRPACGRRPSRLLAikehkalktlgI 243
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958642650 271 FVGCFVFCWFPNHILYLYRSFNykeidPSLGHMIVTLVARVLSFSNSCVNPFaLYLLSESFRKHF 335
Cdd:cd15959   244 IMGTFTLCWLPFFVANIIKVFC-----RSLVPDPAFLFLNWLGYANSAFNPI-IYCRSPDFRSAF 302
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
49-332 1.09e-14

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 73.64  E-value: 1.09e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd14987     6 FYIFIFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVATLPVWVVSLVQHNQWPMGEFTCKITHLIFSINLF 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFsevARIGSSDNSSFTACIP-YPQTDEL 207
Cdd:cd14987    86 GSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLPDTYF---LKTVTSPSNNETYCRSfYPEESFK 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 208 HPKIHSVLIFLVY-FLIPLVIISIYYYHIAKTLIRSAHnlpgeynehtkkqmETRKRLAKIVLVFVGCFVFCWFPNHILY 286
Cdd:cd14987   163 EWLIGMELVSIVLgFVIPFPIIAVFYFLLARAISASSD--------------QERKSSRKIIFSYVVVFLVCWLPYHTVV 228
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 287 LYRSFNYKEIDP---SLGHMIVTL--VARVLSFSNSCVNPFALYLLSESFR 332
Cdd:cd14987   229 LLDILSFLHLIPfscQLENFLYAAlhVTQCFSLVHCCVNPILYSFINRNYR 279
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
48-328 1.30e-14

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 73.23  E-value: 1.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  48 SLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLtCVPVDASRYFFDEWVF-GKLGCKLIPAIQLTS 126
Cdd:cd14964     3 IILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASL-VVLVLFFLLGLTEASSrPQALCYLIYLLWYGA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 127 VGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSftaCIPYPQTde 206
Cdd:cd14964    82 NLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAIPRYNTLTGS---CYLICTT-- 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 207 lhpKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTKKQMetrkRLAKIVLVFVGCFVFCWFPNHILY 286
Cdd:cd14964   157 ---IYLTWGFLLVSFLLPLVAFLVIFSRIVLRLRRRVRAIRSAASLNTDKNL----KATKSLLILVITFLLCWLPFSIVF 229
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1958642650 287 LYrsFNYKEIDPSLGhmIVTLVARVLSFSNSCVNPFALYLLS 328
Cdd:cd14964   230 IL--HALVAAGQGLN--LLSILANLLAVLASTLNPFIYCLGN 267
7tmA_ETBR-LP2 cd15126
endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G ...
49-226 1.51e-14

endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelin B receptor-like protein 2, also called GPR37L1, is almost exclusively expressed in the nervous system. It has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37L1 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320254  Cd Length: 298  Bit Score: 73.36  E-value: 1.51e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd15126     6 LALVVFAVGIVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPVVVFNEITKKRLLGDVSCRVVPYMEVTSLG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPMdMQTSGVVLWTSL--KAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFT-ACIPYPQTD 205
Cdd:cd15126    86 VTTFSLCALGIDRFHAATSPQ-PKARPVERCQSIlaKLAVIWVGSMTLAVPELLLWQLAQETSPGSGMVIdTCIMKPSPN 164
                         170       180       190
                  ....*....|....*....|....*....|.
gi 1958642650 206 eLHPKIHSVLI----------FLVYFLIPLV 226
Cdd:cd15126   165 -LPESLYSLVLtyqnarmwwyFGCYFCLPIL 194
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
51-335 1.57e-14

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 73.08  E-value: 1.57e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  51 LIIISVGLL------GNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd17790     2 LIVITTGILslvtvtGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVArIGSSDNSSFTACIPYpqt 204
Cdd:cd17790    82 VASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAPAILFWQYL-VGERTVLAGQCYIQF--- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 deLHPKIHSVLIFLVYFLIPLVIISIYYYHIaktlirsahnlpgeYNEhTKKQMETRKRLAKIVLVfvgcFVFCWFPNHI 284
Cdd:cd17790   158 --LSQPIITFGTAIAAFYLPVTIMIILYWRI--------------YRE-TIKEKKAARTLSAILLA----FILTWTPYNI 216
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 285 LYLYRSFNYKEIDPSLGHMivtlvARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd17790   217 MVLVSTFCKDCVPKTLWEL-----GYWLCYVNSTVNPMCYALCNKSFRDTF 262
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
45-335 1.64e-14

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 73.03  E-value: 1.64e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15321     8 AIAAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDV 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFsevarigSSDNSSFTACIPYPQT 204
Cdd:cd15321    88 LFCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIY-------KGKQKDEQGGLPQCKL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHPKIHSVLIflVYFLIPLVIISIYY---YHIAKTlirsahnlpgeynehtkkqmeTRKRLAKIVLVFVGCFVFCWFP 281
Cdd:cd15321   161 NEEAWYILSSSI--GSFFAPCLIMILVYlriYLIAKN---------------------REKRFTFVLAVVIGVFVLCWFP 217
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 282 nhilyLYRSFNYKEIDPSLGHMIVTLVARV--LSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15321   218 -----FFFSYSLGAICPELCKVPHSLFQFFfwIGYCNSSLNPVIYTIFNQDFRRAF 268
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
56-321 2.01e-14

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 72.93  E-value: 2.01e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  56 VGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSVFTLT 135
Cdd:cd15121    13 LGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLT-APFFLHFLSGGGWEFGSVVCKLCHYVCGVSMYASIFLIT 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 136 ALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARigssDNSSFTACIPYpQTDELHPKIHSVL 215
Cdd:cd15121    92 LMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSLPMPFYRTVLK----KNINMKLCIPY-HPSVGHEAFQYLF 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 216 IFLVYFLIPLVIISIYYYHIAKTLiRSAhnlpgeynehtkkQMETRKRLAKIVLVFVGCFVFCWFPNHILYLYRSFNYKE 295
Cdd:cd15121   167 ETITGFLLPFTAIVTCYSTIGRRL-RSA-------------RFRRKRRTNRLVVLIIATFALFWLPYHVVNLIQVAGALQ 232
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1958642650 296 IDPSLGHMIVTL-VAR----VLSFSNSCVNP 321
Cdd:cd15121   233 NQAGNASVLKAAkLARpnvtALAFLSSSVNP 263
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
45-333 3.29e-14

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 72.48  E-value: 3.29e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDAsrYFF---DEWVFGKLGCKLIPA 121
Cdd:cd15373     2 LLPVSYGIVFVVGLVLNILALYVFLFRTKPWNASTTYMFNLAISDTLYVLS-LPLLV--YYYadeNDWPFSEALCKIVRF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 122 IQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEvarigSSDNSSFTACIPY 201
Cdd:cd15373    79 LFYTNLYCSILFLLCISVHRFLGVCYPVRSLRWLKVRYARIVSVVVWVIVLACQSPVLYFVT-----TSDKGGNITCHDT 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 202 PQTDELHP-KIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNlpgeynehTKKQMETRKRLAKIVLVFVGCFVFCWF 280
Cdd:cd15373   154 SSPELFDQfVVYSSVMLVLLFCVPFVVILVCYALMVRKLLKPSAG--------TSTNSRSKKKSVKMIIIVLAVFILCFL 225
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 281 PNHIL-YLYRSFNYKEIDPSLGHMIVTL--VARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15373   226 PFHVTrTLYYSFRSMDLSCGTLNAINLAykVTRPLASANSCLDPILYFLAGQSFRS 281
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
54-335 3.48e-14

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 72.39  E-value: 3.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  54 ISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSVFT 133
Cdd:cd15312    11 ILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDMMLSTTSIFH 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 134 LTALSADRYRAIVNP----MDMQTSGVVLWTSLKavgiWVVSVLLAVpEAVFSEVARIGSSD----NSSFTACIPypqtd 205
Cdd:cd15312    91 LCFIAVDRYYAVCDPlhyrTKITTPVIKVFLVIS----WSVPCLFAF-GVVFSEVNLEGIEDyvalVSCTGSCVL----- 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 206 eLHPKIHSVLIFLVYFLIP-LVIISIYYY--HIAKTLIRSAHNLPGEYNEHTKKQMETRK--RLAKIVLVFVGCFVFCWF 280
Cdd:cd15312   161 -IFNKLWGVIASLIAFFIPgTVMIGIYIKifFVARKHAKVINNRPSVTKGDSKNKLSKKKerKAAKTLSIVMGVFLLCWL 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958642650 281 PNHILYLyrsfnykeIDPSLGHMIVTLVARVL---SFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15312   240 PFFVATL--------IDPFLNFSTPVDLFDALvwlGYFNSTCNPLIYGFFYPWFQKAF 289
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
48-335 4.38e-14

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 72.27  E-value: 4.38e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  48 SLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVP--VDASRYFFDEWvfgkLGCKLIPAIQLT 125
Cdd:cd15069     5 ALELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPfaITISLGFCTDF----HSCLFLACFVLV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 126 SVGVSVFTLTALSADRYRAIVNPMDMQTsgvvLWTSLKAVGIWVVSVLLAVpeaVFSEVARIGSSDNSSFTACI--PYPQ 203
Cdd:cd15069    81 LTQSSIFSLLAVAVDRYLAIKVPLRYKS----LVTGKRARGVIAVLWVLAF---GIGLTPFLGWNKAMSATNNStnPADH 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELHPKIHSVLI-------FLVYF------LIPLVIISIYYYHIAKTLIRSAHNLpgEYNEHTKKQMETRKRLAKIVLV 270
Cdd:cd15069   154 GTNHSCCLISCLFenvvpmsYMVYFnffgcvLPPLLIMLVIYIKIFLVACRQLQRT--ELMDHSRTTLQREIHAAKSLAI 231
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642650 271 FVGCFVFCWFPNHILYLYRSFN--YKEIDPSLghmiVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15069   232 IVGIFALCWLPVHILNCITLFQpeFSKSKPKW----AMNVAILLSHANSVVNPIVYAYRNRDFRYTF 294
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
45-335 4.40e-14

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 71.53  E-value: 4.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVG-LLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQ 123
Cdd:cd15329     1 VLIGIVLLIIILGtVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPeAVFsevarIGSSDNSSFTACIpypQ 203
Cdd:cd15329    81 VLLCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISIP-PLF-----GWKNKVNDPGVCQ---V 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELHPKIHSVLIflvYFLIPLVIISIYYYHIAKTlirsahnlpgeynehTKKQMETRKRLAkivlVFVGCFVFCWFPNH 283
Cdd:cd15329   152 SQDFGYQIYATFG---AFYIPLIVMLVLYYKIYRA---------------AKSERKAIKTLG----IIMGAFTLCWLPFF 209
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958642650 284 ILYLYRSFnYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15329   210 ILALLRPF-LKPIKCSCIPLWLSRLFLWLGYANSFLNPIIYAKFNREFRTPF 260
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
46-323 5.69e-14

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 71.65  E-value: 5.69e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFF-DEWVFGKLGCKLIPAIQL 124
Cdd:cd15967     3 LPPVYILVFVVGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADLLYLLT-LPFLVVYYLKgRKWIFGQVFCKITRFCFN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVarigssdNSSFTACipYPQT 204
Cdd:cd15967    82 LNLYGSIGFLTCISVYRYLAIVHPMRVMGRITTTHSVVISALVWLLVVIQSLPDLFFSKT-------NSNGTKC--FDTT 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHPK---IHSVLIFLVYFLIPLVIISIYYYHIAKTLIRsahnlpgeyNEHTKKQMetRKRLAKIVLVFVGCFVFCWFP 281
Cdd:cd15967   153 FNDYLEsylTYSLGWTVTGFVIPLLIILGCYGHVVVVLCR---------NNNVDKGL--KQRCLKLVIILIVLFSVCYIP 221
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1958642650 282 NHILylyRSFNykeidpslghmivtLVARVLSFSNSCVNPFA 323
Cdd:cd15967   222 YHVF---RNLN--------------LLSRILQKQGSCTQWFR 246
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
49-352 6.82e-14

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 71.86  E-value: 6.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVpNIFISNLAAGDLLLLLTCVPVDASRyfFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:PHA02834   34 FYILLFIFGLIGNVLVIAVLIVKRFMFVV-DVYLFNIAMSDLMLVFSFPFIIHND--LNEWIFGEFMCKLVLGVYFVGFF 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPMDMQTSGVVLwTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTAcipypqtdelH 208
Cdd:PHA02834  111 SNMFFVTLISIDRYILVVNATKIKNKSISL-SVLLSVAAWVCSVILSMPAMVLYYVDNTDNLKQCIFND----------Y 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 209 PKIHSVLIFL-----VYFLIPLVIISIYYYHIAKTLIRSAHNlpgeynehtkkqmETRKRLAKIVLVFVGCFVFCWFP-N 282
Cdd:PHA02834  180 HENFSWSAFFnfeinIFGIVIPLIILIYCYSKILYTLKNCKN-------------KNKTRSIKIILTVVTFTVVFWVPfN 246
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958642650 283 HILYLYRSFNYKEIDPSLGHMIVTL----VARVLSFSNSCVNPFALYLLSESFRKHFNSQLCCGQKSYPERSTS 352
Cdd:PHA02834  247 IVLFINSLQSVGLIDIGCYHFKKIVysidIAELISFVHCCVNPIIYAFVGKNFKKVFKNMFCRTNNIFIRQSSN 320
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
46-333 1.14e-13

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 70.71  E-value: 1.14e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFD-EWVFGKLGCKLIPAIQL 124
Cdd:cd15377     3 LPAVYILVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLT-LPALIFYYFNKtDWIFGDAMCKLQRFIFH 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMD----MQTSGVVLWTSLkavgIWVVSVLLAVPEAVFSevaRIGSSDNSSFTaCIP 200
Cdd:cd15377    82 VNLYGSILFLTCISVHRYTGVVHPLKslgrLKKKNAICISVL----VWLIVVVAISPILFYS---GTGVRKNKTIT-CYD 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 201 YPQTDELHPK-IHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEhtkkqmETRKRLAKIVLVFVGCFVFCW 279
Cdd:cd15377   154 TTSDEYLRSYfIYSMCTTVAMFCVPFILILGCYGLIVRALIYKDMKYTEENNA------PLRRKSIYLVIIVLTVFAVSY 227
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 280 FPNHILylyRSFNYK-EIDPSLGHMI--------VTLVARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15377   228 LPFHVM---KTLNLRaRLDFQTPAMCafndrvyaTYQVTRGLASLNSCVDPILYFLAGDTFRR 287
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
49-335 1.19e-13

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 71.03  E-value: 1.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNI---FISNLAAGDLLLLLTCVPVDASRY--FFDEWVFGKLGCKLIPAIQ 123
Cdd:cd15355     6 IYLALFVVGTVGNSITLYTLARKKSLQHLQSTvhyHLASLALSDLLILLLAMPVELYNFiwVHHPWAFGDAACRGYYFLR 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPeAVFSEVARIGSSDNSSFTACIPYPQ 203
Cdd:cd15355    86 DACTYATALNVASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASALLAIP-MLFTMGEQNRSGTHPGGLICTPIVD 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELHPKIhSVLIFLVyFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTKKQMETRKRLA-------------KIVLV 270
Cdd:cd15355   165 TSTLKVVI-QVNAFLS-FLFPMLVISVLNTLIANQLTVMVNQAEQENQVCTIGGQRTVLSVSmepgrvqslrhgvLVLRA 242
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958642650 271 FVGCFVFCWFPNHI---LYLYRSFNYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15355   243 VVIAFVVCWLPYHVrrlMFCYVSDEQWTTFLYDFYHYFYMLTNVLFYVSSAINPILYNLVSANFRQIF 310
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
49-332 1.31e-13

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 70.62  E-value: 1.31e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd15166     6 FYSFIFIIGLFVNITALWVFSCTTKKRTTVTVYMMNVALVDLIFILS-LPFRMVYYAKDEWPFGDYFCRILGALTVFYPS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEvariGSSDNSSFTACIpyPQTDELH 208
Cdd:cd15166    85 IALWLLAFISADRYMAIVQPKHAKELKNTPKAVLACVGVWIMTLASTFPLLFLYE----DPDKASNFTTCL--KMLDIIH 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 209 PKIHSVLIF---LVYFLIPLVIISIYYYHIAKTLIRSahnlpgeynEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNHIL 285
Cdd:cd15166   159 LKEVNVLNFtrlIFFFLIPLFIMIGCYLVIIHNLVHG---------RTSKLKPKVKEKSIRIIITLIVQVLVCFVPFHIC 229
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1958642650 286 YLYRSFNYKEIDPSLGHMIVTLVARVlsfsNSCVNPFALYLLSESFR 332
Cdd:cd15166   230 FAFLMLQNGDNSYNPWAAFTTFLMNL----STCLDVILYYIVSKQFQ 272
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
49-332 1.33e-13

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 70.57  E-value: 1.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd15398     6 LYTFISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQCVSVM 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPMdmqTSGVVLWTSLKAVG-IWVVSVLLAVPEAVFSEVARIGSSDNS----SFTACIPYPQ 203
Cdd:cd15398    86 VSTLMLMSIAIVRYHMIKHPL---SNHLTANHGYFLLGtVWTLGFTICSPLPVFHKIVDLSETFNLeslkNKYLCIESWP 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELHPKIHSVLIFLVYFLiPLVIISIYYYHIAKTLIRSAhnlpgeynehtkkqmETRKRLAKIVLVfvgcFVFCWFPNH 283
Cdd:cd15398   163 SDSYRIAFTISLLFVQYIL-PLVCLTVSHTSVCRSVKRSR---------------SVFYRLTIVILA----FAVSWMPLH 222
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1958642650 284 ILYLYRSFNYKEIDpSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFR 332
Cdd:cd15398   223 LFHLVTDFNANLIS-NRHFKLVYCICHLLGMLSCCLNPILYGFLNNGIK 270
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
58-332 1.43e-13

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 70.17  E-value: 1.43e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  58 LLGNIMLVKIFLTNSTMRSVpnIFISNLAAGDLLLLLTCVPVD--ASRYFFDEWVFGKLGCKLIPAIQLTSVGVSVFTLT 135
Cdd:cd15220    14 LVGNTAVMVVIAKTPHLRKF--AFVCHLCVVDLLAALLLMPLGilSSSPFFLGVVFGEAECRVYIFLSVCLVSASILTIS 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 136 ALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPeAVFSEVAriGSSDNSSFTACIPYPQTDELHPKIHSVL 215
Cdd:cd15220    92 AISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLL-PVLGWPS--YGGPAPIAARHCSLHWSHSGHRGVFVVL 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 216 IFLVYFLIPLVIISIYYYHIAKTlirsahnLPGeynehtkkqmetrKRLAKIVLVFVGCFVFCWFPNHILYLYRSFNYKE 295
Cdd:cd15220   169 FALVCFLLPLLLILVVYCGVFKV-------FGG-------------GKAALTLAAIVGQFLCCWLPYFAFHLYSALAASP 228
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1958642650 296 IDPSLGHMIVTLVArvlsFSNSCVNPFALYLLSESFR 332
Cdd:cd15220   229 VSGGEAEEVVTWLA----YSCFAVNPFFYGLLNRQIR 261
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
45-333 1.61e-13

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 70.11  E-value: 1.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLtCVPVDASRYFF-DEWVFGKLGCKLIPAIQ 123
Cdd:cd15148     2 PLAVFYSLIFLFGLVGNLLALWVFLFIHRKRNSVRIFLINVAIADLLLII-CLPFRILYHVNnNQWTLGPLLCKVVGNLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEvarigssDNSSFTACIPYPQ 203
Cdd:cd15148    81 YMNMYISIILLGFISLDRYLKINRSSRRQKFLTRKWSIVACGVLWAVALVGFVPMIVLTE-------KNEESTKCFQYKD 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 -TDELHPKIHSVLIFLVYFLIPLVIIsIYYYHIAKTLIRSAHNLPGEYNEHtkKQMETRKRLAKIVLVFVGCFVfcwfPN 282
Cdd:cd15148   154 rKNAKGKAIFNFLIVAMFWLVFLLLI-LSYGKIAKKLLRISRDKPDFPNAA--KYNRTARKSFFVLFIFTVCFV----PY 226
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958642650 283 HIL-YLYRSFNYKEIDPSLGHMIVTLVARVLSFS--NSCVNPFALYLLSESFRK 333
Cdd:cd15148   227 HAFrIFYITSQLQNNSCYWKEILHKTNEIMLLLSafNSCLDPVMYFLLSSSIRK 280
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
45-335 1.91e-13

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 69.98  E-value: 1.91e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIF---ISNLAAGDLLLLLTCVPVDASRY--FFDEWVFGKLGCKLI 119
Cdd:cd15130     2 LVTAIYLALFVVGTVGNSVTLFTLARKKSLQSLQSTVryhLGSLALSDLLILLLAMPVELYNFiwVHHPWAFGDAGCRGY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 120 PAIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAV-FSEVARIGSSDNSSFTAC 198
Cdd:cd15130    82 YFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFtMGLQNESDDGTHPGGLVC 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 199 IPYPQTDELHPKIHsvLIFLVYFLIPLVIISIYYYHIAKTLIRSAhnlpgeynehtkkqmetrKRLAKIVLVFVGCFVFC 278
Cdd:cd15130   162 TPIVDTATLKVVIQ--VNTFMSFLFPMLVTSILNTVIANKLVQAL------------------RRGVLVLRAVVIAFVVC 221
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 279 WFPNH---ILYLYRSfNYKEIDPSLG-HMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15130   222 WLPYHvrrLMFCYIS-DEQWTTFLFDfYHYFYMLTNALFYVSSAINPILYNLVSANFRQVF 281
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
40-335 2.33e-13

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 69.29  E-value: 2.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  40 LVIRCVIPSLYLIIIsvglLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLI 119
Cdd:cd15059     1 VAISSIVSVVILLII----VGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIW 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 120 PAIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPeAVFSEVARIGSSDnssftaci 199
Cdd:cd15059    77 LALDVLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLP-PLFGWKDEQPWHG-------- 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 200 PYPQTdELHPKIHSVLI-FLVYFLIPLVIISIYYYHIaktlirsahnlpgeYNEHTKKQmetrKRLAKIVLVFVGCFVFC 278
Cdd:cd15059   148 AEPQC-ELSDDPGYVLFsSIGSFYIPLLIMIIVYARI--------------YRAAKRKE----RRFTLVLGVVMGAFVLC 208
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642650 279 WFPNHILYLYRSFNYKEIDPSLghmiVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15059   209 WLPFFFTYPLVVVCKTCGVPEL----LFKFFFWLGYCNSALNPVIYTIFNKDFRRAF 261
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
45-333 2.45e-13

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 69.83  E-value: 2.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLtCVPVdasRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15920     2 TLPVMYSIICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLLVL-CLPF---RVAYQNTAGPLSFCKIVGAFFY 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPeaVFSEVARIGSSDNSSFtacipYPQT 204
Cdd:cd15920    78 LNMYASILFLSLISLDRYLKIIKPLQQFKIHTVPWSSAASGGVWLLLLACMIP--FLFESRNEGPCDNKCF-----HFRS 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHPKIHSVLIFLVYFLIPLVIISIYyyhiaktlIRSAHNLPGEYNEHTKKQ-METRKRLAKIVLVFVGCFVFCWFPNH 283
Cdd:cd15920   151 KGLTAGGINLTAVVIFYILSLLFLYFY--------AKISHKLYKVSLGNAQQQiKKASKRAIIKTFIVLAIFIVCFVPYH 222
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958642650 284 ILYLYRSFNYKEIDPSLG-----HMIVTLVArVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15920   223 IVRVPYVLAQIDVISSLPwkqtlHIANELVL-CLSALNSCLDPIIYFFLSSSFRR 276
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
46-329 2.58e-13

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 69.44  E-value: 2.58e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLtnSTMRSVPN-IFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15371     3 IPAVYIIVVVLGVPSNAIILWMLF--FRLRSVCTaIFYANLAISDLLFCITLPFKIVYHLNGNNWVFGETMCRIITITFY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACIPYPQT 204
Cdd:cd15371    81 GNMYCSILLLTCISINRYLAIVHPFIYRSLPKKTYAVLICALVWTIVFLYMLPFFILKQTYYLKELNITTCHDVLPECEQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGeynehtkkqmetrkrLAKIVLVFVGCFVFCWFPNHI 284
Cdd:cd15371   161 NSNFQFYYFISMAVFGFLIPLVITIFCYISIIRTLNAYEHKWFW---------------YVKITALVLIIFTICFAPSNV 225
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1958642650 285 LYLYRSFNYKEIDPSLGHMIVtLVARVLSFSNSCVNPFALYLLSE 329
Cdd:cd15371   226 ILIIHHFNYYYFNNDNLYSIY-LIALCLGSLNSCLDPFLYFLMSK 269
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
45-332 4.52e-13

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 68.95  E-value: 4.52e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15160     2 FLPVVYSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLYILTLPLWIDYTANHHNWTFGPLSCKVVGFFFY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMD---MQTSGVVLWTSlkaVGIWVvsVLLAVPEAVFSEVARIGSSDNssFTACIPY 201
Cdd:cd15160    82 TNIYASIGFLCCIAVDRYLAVVHPLRfrgLRTRRFALKVS---ASIWV--LELGTHSVFLGHDELFRDEPN--HTLCYEK 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 202 PQTDELHPKIHsVLIFLVYFLIPLVIISIYYYHIaktlIRSAHNLPGEYNEhTKKQMetRKRLAKIVLVFVGCFVfcwfP 281
Cdd:cd15160   155 YPMEGWQASYN-YARFLVGFLIPLSLILFFYRRV----LRAVRQSPSLERE-EKRKI--IGLLLSIVVIFLLCFL----P 222
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958642650 282 NHILYLYRS--FNYKEIDPSLGHMIVTL--VARVLSFSNSCVNPFALYLLSESFR 332
Cdd:cd15160   223 YHVVLLVRSviELVQNGLCGFEKRVFTAyqISLCLTSLNCVADPILYIFVTEDVR 277
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
45-335 5.36e-13

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 68.54  E-value: 5.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLtCVPVDASRYFFD-EWVFGKLGCKLIPAIQ 123
Cdd:cd15201     2 VLPPVLILEFVLGLLGNGLALWIFCFHLKSWKSSTVYLFNLAVADFLLII-CLPFRTDYYLRGkHWKFGDIPCRIVLFML 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVpeAVFSE---VARIGSSDNSSFTACIP 200
Cdd:cd15201    81 AMNRAGSIFFLTAVAVDRYFRVVHPHHRINSISVRKAAIIACGLWLLTIAMTV--YLLTKkhlFPRGNATQCESFNICTG 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 201 YPQTDELHPkihsvLIFLVYFLIPLVIISIYYYHIAKTLIRsahnlpgeyneHTKKQMETRKRLAKIVLVFVGCFVFCWF 280
Cdd:cd15201   159 TDSSSNWHE-----AMFLLEFFLPLAIILYCSVRIIWQLRG-----------RQLDRHAKIKRAVQFIMVVAIVFIICFL 222
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958642650 281 PN---HILYLYRSFNYKEIDPSLGHMIVTLVARV-LSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15201   223 PSnvtRIAIWILKHTSNEDCQYYRSVDLAFYITIsFTYFNSMLDPVVYYFSSPSFKNFY 281
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
46-332 9.41e-13

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 67.89  E-value: 9.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLtCVPVDASRYF-FDEWVFGKLGCKLIPAIQL 124
Cdd:cd15199     3 YASLLILEFGLGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLI-CLPFKAYFYLnGNRWSLGGGTCKALLFMLS 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVarigssdnSSFTACIPY-PQ 203
Cdd:cd15199    82 LSRGVSIAFLTAVALDRYFRVVHPRGKKNSLSLQAAPYISFLVWLLLVGLTIPTLLASQP--------KNFTECNSFsPK 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLpgeynehtKKQMETRKRLA---KIVLVFVGCFVFCWF 280
Cdd:cd15199   154 DDEDFSDTWQEAVFFLQFLLPFGLIVFCTVRIIRRLKKRLRDV--------GKQPKLQRAMAlvtSVVVVFGFCFLPCFL 225
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958642650 281 PNHILYLYRSFNYKEIDPSLGHmiVTLVARVLSFSNSCVNPFALYLLSESFR 332
Cdd:cd15199   226 ARVLMLIFQNKESCNALNIAVH--TYDVTMCLTYLNSVLDPIVYCFSSPTFR 275
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
52-335 9.52e-13

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 68.15  E-value: 9.52e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSV 131
Cdd:cd15065     8 LIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCSTASI 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 132 FTLTALSADRYRAIVNPMD----MQTSGVVLWTSLkavgIWVVSVLLA-VPeaVFSEVARIGSSDNSSF-TACIPYPQTD 205
Cdd:cd15065    88 LNLCAISLDRYIHIKKPLKyerwMTTRRALVVIAS----VWILSALISfLP--IHLGWHRLSQDEIKGLnHASNPKPSCA 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 206 -ELHPkIHSVLIFLVYFLIP-LVIISIYY--YHIAKTLIRS--AHNLPGEYNEHTKKQMETRKR--------LAKIVL-V 270
Cdd:cd15065   162 lDLNP-TYAVVSSLISFYIPcLVMLLIYSrlYLYARKHVVNikSQKLPSESGSKFQVPSLSSKHnnqgvsdhKAAVTLgI 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958642650 271 FVGCFVFCWFPNHILYLYRSFNyKEIDPSLGHMIVTLvarvLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15065   241 IMGVFLICWLPFFIINIIAAFC-KTCIPPKCFKILTW----LGYFNSCLNPIIYSIFNSEFRRAF 300
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
41-321 1.04e-12

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 67.78  E-value: 1.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  41 VIRCVIPSLyliIISVGLLGNIMLVKIFLTNstmRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIP 120
Cdd:cd15104     4 VILAVLSPL---IITGNLLVIVALLKLIRKK---DTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRM 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 121 AIQLTSVGVSVFTLTALSADRYRAIVNPMDMqtsgVVLWTSLKA----VGIWVVSVLLAVPEAVFSEVARIGSSDNSSFT 196
Cdd:cd15104    78 CFVITSCAASVLSLAAIAFDRYLALKQPLRY----KQIMTGKSAgaliAGLWLYSGLIGFLPLISPQFQQTSYKGKCSFF 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 197 ACIpypqtdelHPKIHSVLIFLVYFLIPLVIISIYYY--------HIAKTLIRSAHNLPGEYNEHTKKQmetrkRLAKIV 268
Cdd:cd15104   154 AAF--------HPRVLLVLSCMVFFPALLLFVFCYCDilkiarvhSRAIYKVEHALARQIHPRRTLSDF-----KAARTV 220
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642650 269 LVFVGCFVFCWFPNHILYLyrsfnykeIDPSLGHMIVTLVARV----LSFSNSCVNP 321
Cdd:cd15104   221 AVLIGCFLLSWLPFQITGL--------VQALCDECKLYDVLEDylwlLGLCNSLLNP 269
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
45-333 1.10e-12

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 67.91  E-value: 1.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLL---TCVPVDASRyffDEWVFGKLGCKLIPA 121
Cdd:cd15374     2 LLPVSYGLVFVVGLPLNATALWLFIKRMRPWNPTTVYMFHLALSDTLYVLslpTLIYYYADH---NHWPFGVVACKIVRF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 122 IQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSdnssfTACIPY 201
Cdd:cd15374    79 LFYANLYCSILFLTCISVHRYVGICHPIRALRWVKPRHAYLICASVWLVVTVCLVPNLIFVTTSRKDNI-----TLCHDT 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 202 PQTDELHPKIH-SVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPgeynehTKKQMETRKRLAKIVLVFVGCFVFCWF 280
Cdd:cd15374   154 TRPEEFDHYVHySSAVMVLLFGIPCLVIVVCYGLMARRLCKPRVGSS------RQQGPSSKKRSLKTIIMVLTVFAICFV 227
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 281 PNHIL-YLYRSFNYKEIDPSLGHMI--VTLVARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15374   228 PFHITrTLYYVARLLKADCDTLNIInvTYKVTRPLASANSCLDPILYFLAGDKYRR 283
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
50-335 1.21e-12

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 67.27  E-value: 1.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  50 YLIIISVglLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGV 129
Cdd:cd15323     9 FLIVFTI--VGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 130 SVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVfsevarigSSDNSSFTACIPYPQTDELHP 209
Cdd:cd15323    87 SIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLI--------SMYRDPEGDVYPQCKLNDETW 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 210 KIHSVLIFlvYFLIPLVIISIYY---YHIAKTlirsahnlpgeynehtkkqmeTRKRLAKIVLVFVGCFVFCWFPnhily 286
Cdd:cd15323   159 YILSSCIG--SFFAPCLIMILVYiriYRVAKA---------------------REKRFTFVLAVVMGVFVVCWFP----- 210
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 287 LYRSFNYKEIDPSLGHMIVTLVARV--LSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15323   211 FFFSYSLYGICREACEVPEPLFKFFfwIGYCNSSLNPVIYTIFNQDFRRSF 261
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
45-333 1.21e-12

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 67.48  E-value: 1.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFF-DEWVFGKLGCKLIPAIQ 123
Cdd:cd15369     2 FVPSVYTIVFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLFVLL-LPFKIAYHFSgNDWLFGEAMCRVVTAAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDnssFTACIPYPQ 203
Cdd:cd15369    81 YCNMYCSILLMTCISVDRFLAVVYPMQSLSWRTLRRASFTCAAIWLLSIAGVVPLLLSEQTIQIPDLG---ITTCHDVLN 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELHPK-IHSVLIF-LVYFLIPLVIISIYYYHIAKTLirSAHNLPGEYNEHTKkqmetrkrlAKIVLVFVGC-FVFCWF 280
Cdd:cd15369   158 EQLLMGYyVYYFSIFsCLFFFVPLIITTVCYVSIIRCL--SSSSDVANSSKKTR---------ALFMAVAVFCvFVICFG 226
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 281 PNHILYLYRSFNYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15369   227 PTNVLLLAHYVRFAYTSTNDASYFAYLLCVCVGSISCCLDPLIYYYGSSQCQK 279
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
48-332 2.47e-12

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 66.66  E-value: 2.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  48 SLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDllllLTCVPVDASRYFF----DEWVFGKLGCKLIPAIQ 123
Cdd:cd15161     5 LFYILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVAD----LSYVLILPMRLVYhlsgNHWPFGEVPCRLAGFLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVsVLLAVPEAVFSEvariGSSDNSSFTACIP-YP 202
Cdd:cd15161    81 YLNMYASLYFLACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVI-VTVAMAPLLVSP----QTVEVNNTTVCLQlYR 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 203 QTdelhPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLirsahnlpgeyneHTKKQMETR-KRLA-KIVLVFVGCFVFCWF 280
Cdd:cd15161   156 EK----ASRGALVSLAVAFTIPFVTTVTCYLLIIRSL-------------RTGKREEKPlKDKAiKMIILVLTIFLICFV 218
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642650 281 PNHI-LYLY-RSFNYKEIDPSLGHMIvTLVARV---LSFSNSCVNPFALYLLSESFR 332
Cdd:cd15161   219 PYHIsRYIYiLSHNGAGASCSSRRGL-ALANRItscLTCLNGALDPVMYFFVAEKFR 274
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
52-335 2.71e-12

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 66.51  E-value: 2.71e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVGLL------GNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLT 125
Cdd:cd15322     3 LIILVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 126 SVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVfsevarigSSDNSSFTACIPYPQTD 205
Cdd:cd15322    83 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI--------TIEKKSGQPEGPICKIN 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 206 ElhPKIHSVLIFLVYFLIPLVIISIYY---YHIAKTlirsahnlpgeynehtkkqmeTRKRLAKIVLVFVGCFVFCWFPN 282
Cdd:cd15322   155 D--EKWYIISSCIGSFFAPCLIMVLVYiriYQIAKN---------------------REKRFTFVLAVVIGVFVICWFPF 211
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 283 HILYLYRSFNYKEIDPSLGHMIVTlvarvLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15322   212 FFTYTLTAVCDCSVPETLFKFFFW-----FGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
45-335 3.00e-12

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 66.35  E-value: 3.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15296     2 ILAVLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPLYIPYVLTGRWKFGRGLCKLWLVVDY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTS-GVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSdnssftacIPypq 203
Cdd:cd15296    82 LLCTASVFNIVLISYDRFLSVTRAVSYRAQkGMTRQAVLKMVLVWVLAFLLYGPAIISWEYIAGGSI--------IP--- 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 tdelHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIrsahNLPGEYNEHTKK-QMETRKRLAKIVLVFVGCFVFCWFPN 282
Cdd:cd15296   151 ----EGECYAEFFYNWYFLMTASTLEFFTPFISVTYF----NLSIYLNIQKRRfRLSRDKKVAKSLAIIVCVFGLCWAPY 222
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 283 HILYLYRSFNYkeidpslGHMIVTLVARV---LSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15296   223 TLLMIIRAACH-------GHCVPDYWYETsfwLLWVNSAINPVLYPLCHMSFRRAF 271
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
49-341 3.00e-12

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 66.47  E-value: 3.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFD-EWVFGKLGCKLIPAIQLTSV 127
Cdd:cd15305     6 LILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDyAWPLPRYLCPIWISLDVLFS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVfsevarIGSSDNSSFTACIPYPQTDEL 207
Cdd:cd15305    86 TASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGISMPIPV------IGLQDDEKVFVNGTCVLNDEN 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 208 HPKIHSvlifLVYFLIPLVIISIYYYHIAKTLIRsahnlpgeynehtKKQMETRKRLAKIVLVFVGCFVFCWFPNHILYL 287
Cdd:cd15305   160 FVLIGS----FVAFFIPLIIMVITYCLTIQVLQR-------------QQAINNERRASKVLGIVFFLFLIMWCPFFITNI 222
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958642650 288 YRSFNYKEIDPSLGHMIVTLVARVlSFSNSCVNPFALYLLSESFRKHFNSQLCC 341
Cdd:cd15305   223 LSVLCKEACDQKLMEELLNVFVWV-GYVSSGINPLVYTLFNKTYRRAFSNYIRC 275
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
49-330 3.23e-12

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 66.41  E-value: 3.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd15156     6 VFSMVFVLGLIANCVAIYIFMCTLKVRNETTTYMINLAISDLLFVFT-LPFRIFYFVQRNWPFGDLLCKISVTLFYTNMY 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSftaCIPYPQTDELH 208
Cdd:cd15156    85 GSILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAVWLTVLAGSLPASFFQSTNNQLNNNSET---CFENFSSKTWK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 209 PKIHSVLIFL--VYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNehtkkqmetRKRLAKIVLVFVGCFVFCWFP---NH 283
Cdd:cd15156   162 TYLSKIVIFIeiVGFFIPLILNVTCSTMVLKTLRRPNTLSRSKLN---------KKKVLKMIFVHLFIFCFCFIPynvNL 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1958642650 284 ILY-LYRSFNYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSES 330
Cdd:cd15156   233 VLYsLVRTQTFKNCSVVAAVRTMYPITLCIAVSNCCFDPIVYYFTSET 280
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
46-335 3.52e-12

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 66.20  E-value: 3.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLT 125
Cdd:cd15300     3 IAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALDYV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 126 SVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPeAVFSEVARIGSSdnssfTACIPYPQTD 205
Cdd:cd15300    83 ASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAP-PILCWQYFVGKR-----TVPERECQIQ 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 206 ELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKtlirsahnlpgeyneHTKKQMETRKRLAKIVLVfvgcFVFCWFPNHIL 285
Cdd:cd15300   157 FLSEPTITFGTAIAAFYIPVSVMTILYCRIYK---------------ETIKERKAAQTLSAILLA----FIITWTPYNIM 217
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958642650 286 YLYRSFNYKEIDPSLGHMivtlvARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15300   218 VLVSTFCSDCIPLTLWHL-----GYWLCYVNSTVNPMCYALCNKTFRKTF 262
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
51-335 3.71e-12

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 66.08  E-value: 3.71e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  51 LIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVS 130
Cdd:cd15402     8 IFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMGLSVIGS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 131 VFTLTALSADRYRAIVNPMDMQTsgvvLWTSLKAVG----IWVVSVLLAVPEavfsevARIGSSDNSSFTACIPYPQTDE 206
Cdd:cd15402    88 IFNITGIAINRYCYICHSLKYDK----LYSDKNSLCyvllIWVLTVAAIVPN------LFVGSLQYDPRIYSCTFAQSVS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 207 lhpKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTKKQmeTRKRLAKIVLVFVgCFVFCWFPNHILY 286
Cdd:cd15402   158 ---SAYTIAVVFFHFILPIIIVTFCYLRIWILVIQVRRRVKPDNKPKLKPH--DFRNFVTMFVVFV-LFAVCWAPLNFIG 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1958642650 287 LYRSFNYKEIDPSLGHMIVtLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15402   232 LAVAVDPETIVPRIPEWLF-VASYYMAYFNSCLNAIIYGLLNQNFRREY 279
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
46-332 5.86e-12

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 65.51  E-value: 5.86e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIPAIQLT 125
Cdd:cd15378     3 LPTMYSIEFVLGFIGNTIVILGYIFCLKNWKSSNIYLFNLSVSDLAFLCT-LPMLVYSYSNGQWLFGDFLCKSNRYLLHA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 126 SVGVSVFTLTALSADRYRAIVNPMD---MQTSGVVLWTSLkavGIWVVSVLLAVPEAVFsevarIGSSDNSSFTACIPYP 202
Cdd:cd15378    82 NLYSSILFLTFISIDRYLLIKYPFRehiLQKKRSAVAISL---AIWVLVTLELLPILTF-----IGPNLKDNVTKCKDYA 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 203 QTDELHPK-IHSVLIFLVYFLIPLVIISIYYYHIAKTLirsaHNLPGEYNEHTkkqmeTRKRLAKIVLVFVGCFVFCWFP 281
Cdd:cd15378   154 SSGDATNSlIYSLFLTVTGFLIPLCVMCFFYYKIALFL----KNRNRQLANAT-----SFEKPLTLVILAVVIFSVLFTP 224
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958642650 282 NHILylyRSFNYKEIDPSLGHMIVTL--------VARVLSFSNSCVNPFALYLLSESFR 332
Cdd:cd15378   225 YHVM---RNVRIASRLDSIGVSECTLiiikslyiVTRPIAFLNSVINPVFYFLMGDHFR 280
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
75-328 5.95e-12

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 65.59  E-value: 5.95e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  75 RSVPNIFISNLAAGDLLLLLtCVPVdaSRYFF---DEWVFGKLGCKLIPAIQLTSVGVSVFTLTALSADRYRAIVNPMDM 151
Cdd:cd15118    31 RTVISIWILNLALSDLLATL-SLPF--FTYYLasgHTWELGTTFCRIHSSIFFLNMFVSGFLLAAISLDRCLLVVKPVWA 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 152 QTSGVVLWTSLKAVGIWVVSVLLAVPEAVF-SEVARIGSSDNSSFTACIPYPQTDELHPKIHS------VLIFLVYFLIP 224
Cdd:cd15118   108 QNHRNVAAAKKICGVIWAMALINTIPYFVFrDVIERKDGRKLCYYNFALFSPSPDNNHPICKQrqeglaISKLLLAFLIP 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 225 LVIISIYYYHIAKTLIRSAHNLPGeynehtkkqmetrkRLAKIVLVFVGCFVFCWFPNHIlylyrsFNYKEIDPSLGHMI 304
Cdd:cd15118   188 LVIIAVSYAVVSLIIRHRCRRRPG--------------RFVRLVVSVVVSFALCWAPYHI------FSIIEVMAHNQHSL 247
                         250       260       270
                  ....*....|....*....|....*....|
gi 1958642650 305 VTLVARVL------SFSNSCVNPfALYLLS 328
Cdd:cd15118   248 RPLVIQGLpfattlAFLNSVLNP-VLYVFS 276
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
56-333 6.12e-12

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 65.63  E-value: 6.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  56 VGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSVFTLT 135
Cdd:cd15008    12 VSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTPGVQIYVLL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 136 ALSADRYRAIVNPMDMQTSGVVLWTSLKAVgiWVVSVLLAVPEAVFsevarIGSSDNSSFTACIPYPQTDELHPKIHsvl 215
Cdd:cd15008    92 SICVDRFYTIVYPLSFKVSREKAKKMIAAS--WLFDAAFVSPALFF-----YGSNWGPHCNFFLPDSWDGAAYAIIH--- 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 216 iFLVYFLIPLVIISIYYYHIAKTLIRSahnlpGEYNEHTKKQM----ETRKRLAKIVLVFVGCFVFCWFPNHILYLYRSF 291
Cdd:cd15008   162 -LLVGFLVPSILIILFYQKVIKYIWRI-----GTDGRTVRRTMnivpRTKVKTIKMFLMLNSMFLLSWLPFYVVQLWHPR 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1958642650 292 NYKEIDPSLGHMIVTLVarvlSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15008   236 ESDYRQSSLVFLAVTWI----SFSSSASKPTLYSVYNANFRR 273
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
45-335 6.33e-12

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 65.15  E-value: 6.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFF-DEWVFGKLGCKLIPAIQ 123
Cdd:cd15302     2 LLALITAILSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMPFYTVYVLNgDYWPLGWVLCDLWLSVD 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNP---MDMQTSGVVLWTslkAVGIWVVSVLLAVPeAVFSEVARIGSSDNSSFTACIP 200
Cdd:cd15302    82 YTVCLVSIYTVLLITIDRYCSVKIPakyRNWRTPRKVLLI---IAITWIIPALLFFI-SIFGWQYFTGQGRSLPEGECYV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 201 YPQTDelhPKIHSVLIfLVYFLIPLVIISIYYYHIAKTLIRSahnlpgeynehtkkqmetRKRLAKIVLVfVGCFVFCWF 280
Cdd:cd15302   158 QFMTD---PYFNMGMY-IGYYWTTLIVMLILYAGIYRAANRA------------------RKALRTITFI-LGAFVICWT 214
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958642650 281 PNHILYLYRSFNYkeiDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15302   215 PYHILATIYGFCE---APPCVNETLYTISYYLCYMNSPINPFCYALANQQFKKTF 266
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
49-335 6.96e-12

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 65.18  E-value: 6.96e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDE-WVFGKLGCKLIPAIQLTSV 127
Cdd:cd14988     6 LYLVIFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADLGVVLT-LPVWMLEVMLDYtWLWGSFLCKFTHYFYFANM 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARiGSSDNSSFTAciPYPQTDEL 207
Cdd:cd14988    85 YSSIFFLTCLSVDRYLTLTSSSPFWQQHQHRIRRALCAGIWVLSAIIPLPEVVHMQLLD-GVEPMCLFLA--PFETYDEW 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 208 HPKIhSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAhnlpgeynehtkkQMETRKRLAkIVLVFVGCFVFCWFPNHI--L 285
Cdd:cd14988   162 ALAV-SLLTLIIGFLIPFSIIAVFNVLTARYIRTAG-------------RPESRRHCL-LIYAYILVFVVCWLPYHVtlL 226
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958642650 286 YLYRSFNYKEIDPSLGHMIVTL--VARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd14988   227 LLTLHGSHISLHCNLVHFLYFFydVIDCFSLLHCVANPILYNFLSKSFRGKL 278
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
52-335 8.06e-12

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 65.27  E-value: 8.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSV 131
Cdd:cd15957     9 LIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVLCVTASI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 132 FTLTALSADRYRAIVNPMDMQTsgvvLWTSLKA----VGIWVVSVLLA-VPEAVFSEVArigssDNSSFTACIPYPQ-TD 205
Cdd:cd15957    89 ETLCVIAVDRYFAITSPFKYQS----LLTKNKArviiLMVWIVSGLTSfLPIQMHWYRA-----THQEAINCYAEETcCD 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 206 ELHPKIHSVLIFLVYFLIPLVIISIYY---YHIAKTLIRSAHNLPGEYNEHTKKQMETRKRLA---------------KI 267
Cdd:cd15957   160 FFTNQAYAIASSIVSFYVPLVIMVFVYsrvFQEAKRQLQKIDKSEGRFHNQNIDQNGSGGGGGnrrrskfclkehkalKT 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958642650 268 VLVFVGCFVFCWFPNHILYLYRSFnYKEIDPSLGHMIVTLVARVlsfsNSCVNPFaLYLLSESFRKHF 335
Cdd:cd15957   240 LGIIMGTFTLCWLPFFIVNIVHVI-QDNLIRKEVYILLNWIGYV----NSGFNPL-IYCRSPDFRIAF 301
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
45-335 8.15e-12

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 64.95  E-value: 8.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLgNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15335     3 IVLTLALITILTTVL-NSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVDM 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARigssdnssftacIPYPQT 204
Cdd:cd15335    82 TCCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPPLFWRNHHD------------ANIPSQ 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHpkiHSVLIFLVY-----FLIPLVIISIYYYHIaktlirsahnlpgeYNEHTKKqmetrKRLAKIVLVFVGCFVFCW 279
Cdd:cd15335   150 CIIQ---HDHVIYTIYstfgaFYIPLTLILILYYRI--------------YHAASRE-----RKAARILGLILGAFILSW 207
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 280 FPNHILYLYRSFNYKEIDPSLGHMIVTlvarvLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15335   208 LPFFIKELIVGLSVMTVSPEVADFLTW-----LGYVNSLVNPLLYTSFNEDFKLAF 258
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
52-333 8.55e-12

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 65.30  E-value: 8.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVGLLGNIMLV--KIFLTNSTmrSVPNIFISNLAAGDLLL---LLTCVPVDAS---RYFF--DEWVFGKLgCKLIPA 121
Cdd:cd15137     9 VVGIIALLGNLFVLiwRLKYKEEN--KVHSFLIKNLAIADFLMgvyLLIIASVDLYyrgVYIKhdEEWRSSWL-CTFAGF 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 122 IQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGvvLWTSLKAVG-IWVVSVLLAV-PeavfseVARIGSSDN--SSFTA 197
Cdd:cd15137    86 LATLSSEVSVLILTLITLDRFICIVFPFSGRRLG--LRRAIIVLAcIWLIGLLLAVlP------LLPWDYFGNfyGRSGV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 198 CIPYPQTDELHP-KIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNlpgEYNEHTKKQMETRKRLAKIVLV-Fvgcf 275
Cdd:cd15137   158 CLPLHITDERPAgWEYSVFVFLGLNFLAFVFILLSYIAMFISIRRTRKA---AASRKSKRDMAVAKRFFLIVLTdF---- 230
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958642650 276 vFCWFPNHILYLYRSFNYkEIDPSLGHMIVTLVARVlsfsNSCVNPFaLYLLS-ESFRK 333
Cdd:cd15137   231 -LCWIPIIVIGILALSGV-PIPGEVYAWVAVFVLPI----NSALNPI-LYTLStPKFRK 282
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
109-335 1.07e-11

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 64.96  E-value: 1.07e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 109 WVFGKLGCKLIPAIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVpEAVFSEVARIG 188
Cdd:cd15314    66 WYFGDLFCKIHSSFDITLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGF-GIIFLELNIKG 144
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 189 SSDN--SSFTACIpypqtdELHPKIHSVLIFLVYFLIPLVII-SIYY--YHIAKTLIRSAHNLpGEYNEHTKKQMEtrKR 263
Cdd:cd15314   145 IYYNhvACEGGCL------VFFSKVSSVVGSVFSFYIPAVIMlCIYLkiFLVAQRQARSIQSA-RTKSGASSSKME--RK 215
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958642650 264 LAKIVLVFVGCFVFCWFPnhilylyrSFNYKEIDPSLGHMIVTLVARVL---SFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15314   216 ATKTLAIVMGVFLLCWTP--------FFLCNIIDPFINYSIPPVLIEVLnwlGYSNSTLNPFIYAFFYSWFRKAF 282
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
49-335 1.18e-11

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 65.02  E-value: 1.18e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVgLLGNIMLVKIFLTNSTMRS-VPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLgCKLIPAIQLTSV 127
Cdd:cd15320     8 LSVLILST-LLGNTLVCAAVIRFRHLRSkVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSF-CNIWVAFDIMCS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLA-VP-EAVFSEVARIGSSDNSSFTACIPYPQTD 205
Cdd:cd15320    86 TASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISfIPvQLNWHKAKPTSFLDLNASLRDLTMDNCD 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 206 ELHPKIHSVLIFLVYFLIPLVIISIYY---YHIAKTLIR-------------SAHNLPGEYNEHTKKQMETRKRLA---- 265
Cdd:cd15320   166 SSLNRTYAISSSLISFYIPVAIMIVTYtriYRIAQKQIRrisaleraavhakNCQNSTGNRGSGDCQQPESSFKMSfkre 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 266 ----KIVLVFVGCFVFCWFPNHILYLYRSFNYKE------IDPSLGHMIVTlvarvLSFSNSCVNPFaLYLLSESFRKHF 335
Cdd:cd15320   246 tkvlKTLSVIMGVFVCCWLPFFILNCMVPFCKPTstepfcISSTTFDVFVW-----FGWANSSLNPI-IYAFNADFRKAF 319
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
49-332 1.20e-11

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 64.46  E-value: 1.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIII-SVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCV--PVDASRYFFDEWVFgklgCKLIPAIQLT 125
Cdd:cd14989     5 LYTIFLfPIGFIGNILILVVNLSFREKMTIPDLYFVNLAVADLILVADSLieVFNLNEKYYDIAVL----CTFMSLFLQI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 126 SVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVpeavfsevarigssdnSSFTAcIPYPQTD 205
Cdd:cd14989    81 NMYSSIFFLTWMSFDRYIALAKVMKSSPLRTMQHARLSCGLIWMASISATL----------------LPFTA-VQAQHTG 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 206 ELH------PKIHSVLIFLvYFLIPLVIISIYYYHIAKTLIRSahnlpgeyneHTKKQMETRKRLA-KIVLVFVGCFVFC 278
Cdd:cd14989   144 EVHfcfadvREIQWLEVTL-GFIIPFSIIGLCYSLIVRVLVRA----------QKHRRLRPRRQKAlRMILVVVLVFFIC 212
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958642650 279 WFPNHILYLYRSFNYKE-----IDPSLGH------MIVTLVArvlsFSNSCVNPFALYLLSESFR 332
Cdd:cd14989   213 WLPENVFISIQLLQGTQepsesYDESFRHnhpltgHIVNLAA----FSNSCLNPLIYSFLGETFR 273
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
52-335 1.81e-11

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 63.74  E-value: 1.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSV 131
Cdd:cd15324     9 VIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDVLFCTSSI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 132 FTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEvarigssdnSSFTACIPYPQTdelhpkI 211
Cdd:cd15324    89 VHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLLMTK---------HDEWECLLNDET------W 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 212 HSVLIFLVYFLIPLVIISIYYYHIAKtlirsahnlpgeynehTKKQMEtrKRLAKIVLVFVGCFVFCWFPNHILYLYRSF 291
Cdd:cd15324   154 YILSSCTVSFFAPGLIMILVYCKIYR----------------VAKMRE--KRFTFVLAVVMGVFVLCWFPFFFTYSLHAV 215
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1958642650 292 NYKE--IDPSLGHMIVTlvarvLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15324   216 CRKRcgIPDALFNLFFW-----IGYCNSSVNPIIYTIFNRDFRKAF 256
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
58-333 2.96e-11

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 63.39  E-value: 2.96e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  58 LLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLL---LLTCVPVDASRY--FFD---EWVFGkLGCKLIPAIQLTSVGV 129
Cdd:cd15136    15 LVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADFCMgiyLGLLAIVDAKTLgeYYNyaiDWQTG-AGCKTAGFLAVFSSEL 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 130 SVFTLTALSADRYRAIVNPMD------MQTSGVVLwtslkaVGIWVVSVLLAVpeavfseVARIGSSDNSSFTACIPYpQ 203
Cdd:cd15136    94 SVFTLTVITLERWYAITHAMHlnkrlsLRQAAIIM------LGGWIFALIMAL-------LPLVGVSSYSKTSICLPF-E 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELHPKIHsvLIFLVYF-LIPLVIISIYYYHIAKTLirsahnlpgEYNEHTKKQMETR--KRLAkiVLVFVGcfVFCWF 280
Cdd:cd15136   160 TETPVSKAY--VIFLLLFnGLAFLIICGCYIKIYLSV---------RGSGRAANSNDTRiaKRMA--LLVFTD--FLCWA 224
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958642650 281 PNHILYLYRSFNYKEIdpSLGHMIVTLvarVLSFS-NSCVNPFALYLLSESFRK 333
Cdd:cd15136   225 PIAFFGLTAAFGLPLI--SVSNAKILL---VFFYPlNSCANPFLYAIFTKQFRR 273
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
52-177 3.57e-11

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 63.63  E-value: 3.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVP-VDASRYFFDEWVFGKLGCKLIPAIQLTSVGVS 130
Cdd:cd15005     9 LILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPfVMASVRHGSGWIYGALSCKVIAFLAVLFCFHS 88
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1958642650 131 VFTLTALSADRYRAIVNPMdMQTSGVVLWTSLKAVGI-WVVSVLLAVP 177
Cdd:cd15005    89 AFTLFCIAVTRYMAIAHHR-FYAKRMTFWTCLAVICMaWTLSVAMAFP 135
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
47-287 4.34e-11

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 63.23  E-value: 4.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  47 PSLYLIIISVGLLGNIMLVKIF--LTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFD-EWVFGKLGCKLIPAIQ 123
Cdd:cd15147     4 PIVYSIIFVLGLIANCYVLWVFarLYPSKKLNEIKIFMVNLTIADLLFLIT-LPFWIVYYHNEgNWILPKFLCNVAGCLF 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEaVFSEVARIGSSDNSSFTACIPYPQ 203
Cdd:cd15147    83 FINTYCSVAFLGVISYNRYQAVTRPIKTAQSTTRKRGIIISVAIWVIIVASASYF-LFMDSTNTVKIDSGNFTRCFEGYE 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELHP--KIHSVLIFLvYFLIPLVIIsIYYYHIAKTLIRSahnlpgeyNEHTKKQMETRKRLAKIVLVFVGCFVFCWFP 281
Cdd:cd15147   162 KDNSKPvlIIHFIIIGL-FFLVFLLIL-VCNLVIARTLLSQ--------PVQGQRNAGVKRRALWMVCTVLAVFVICFVP 231

                  ....*.
gi 1958642650 282 NHILYL 287
Cdd:cd15147   232 HHVVQG 237
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
52-322 4.80e-11

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 62.87  E-value: 4.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSV 131
Cdd:cd15388     9 IIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFFQVLPQLVWDITDRFRGPDVLCRLVKYLQVVGMFASS 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 132 FTLTALSADRYRAIVNPMDMQTSGVVLWtSLKAVGIWVVSVLLAVPEA-VFSEVAriGSSDNSSFTACIPYPQTdelhPK 210
Cdd:cd15388    89 YMIVAMTFDRHQAICRPMVTFQKGRARW-NGPVCVAWAISLILSLPQVfIFSKVE--VAPGVYECWACFIEPWG----LK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 211 IHSVLIFLVYFLIPLVIISIYYYHIAKTLIRS----AHNLPGEYNE---HTKKQMET------RKRLAKIVLVFVGCFVF 277
Cdd:cd15388   162 AYVTWITLVVFVLPTLIITVCQVLIFKEIHINiylkSQIIVAVVKKkqlLSSRASSVaevskaMIKTVKMTLVIVLVYVL 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1958642650 278 CWFPNHILYLYRSFNYKEIDPSLGHMIVTLVARVlsfsNSCVNPF 322
Cdd:cd15388   242 CWAPFFLVQLWSVWDPKAPTEGATFTILMLLASL----NSCTNPW 282
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
48-335 4.96e-11

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 62.66  E-value: 4.96e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  48 SLYLIIISVGLLGNIMLVKIFLTNStMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSV 127
Cdd:cd15334     6 TLSILALMTTAINSLVITAIIVTRK-LHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVDITCC 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVArigssdNSSFTACIpypqtdel 207
Cdd:cd15334    85 TCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLFWRHQT------TSREDECI-------- 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 208 hpKIHSVLIFLVY-----FLIPLVIISIYYYHIAKTlirsahnlpgeynehtkkqmETRKRLAKIVL-VFVGCFVFCWFP 281
Cdd:cd15334   151 --IKHDHIVFTIYstfgaFYIPLALILILYYKIYRA--------------------ATRERKAATTLgLILGAFVICWLP 208
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958642650 282 nhilYLYRSFNYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15334   209 ----FFVKEVIVNTCDSCYISEEMSNFLTWLGYINSLINPLIYTIFNEDFKKAF 258
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
49-335 5.21e-11

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 62.64  E-value: 5.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFD-EWVFGKLGCKLIPAIQLTSV 127
Cdd:cd15304     6 LTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGyRWPLPSKLCAVWIYLDVLFS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFsevariGSSDNSSFTACIPYPQTDEL 207
Cdd:cd15304    86 TASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVF------GLQDDSKVFKEGSCLLADEN 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 208 HPKIHSvlifLVYFLIPLVIISIYYYHIAKTLIRSAHNlpgeynehtkkqmetRKRLAKIVLVFVGCFVFCWFPNHILYL 287
Cdd:cd15304   160 FVLIGS----FVAFFIPLTIMVITYFLTIKSLQQSISN---------------EQKASKVLGIVFFLFVVMWCPFFITNV 220
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1958642650 288 YRSFNYKEIDPSL-GHMIVTLVArvLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15304   221 MAVICKESCNEVViGGLLNVFVW--IGYLSSAVNPLVYTLFNKTYRSAF 267
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
52-321 6.34e-11

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 62.31  E-value: 6.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVG-LLGNIMLVKIFLTNSTMRSVPNIFISNLAAGD----LLLLLTCVPVDASRYFFDEWVFgklgcKLIPAIQLTS 126
Cdd:cd14972     6 IVLGVFiVVENSLVLAAIIKNRRLHKPMYILIANLAAADllagIAFVFTFLSVLLVSLTPSPATW-----LLRKGSLVLS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 127 VGVSVFTLTALSADRYRAIVNPMDMQtSGVVLWTSLKAVGI-WVVSVLLAV-PEAVfsevariGSSDNSSFTACIPYPqt 204
Cdd:cd14972    81 LLASAYSLLAIAVDRYISIVHGLTYV-NNVTNKRVKVLIALvWVWSVLLALlPVLG-------WNCVLCDQESCSPLG-- 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 dELHPKIHSVLIfLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNHI 284
Cdd:cd14972   151 -PGLPKSYLVLI-LVFFFIALVIIVFLYVRIFWCLWRHANAIAARQEAAVPAQPSTSRKLAKTVVIVLGVFLVCWLPLLI 228
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1958642650 285 LYLYRSFNY--KEIDPSLGHMIvtlvarVLSFSNSCVNP 321
Cdd:cd14972   229 LLVLDVLCPsvCDIQAVFYYFL------VLALLNSAINP 261
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
45-342 7.60e-11

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 62.41  E-value: 7.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFIS-NLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQ 123
Cdd:cd15376     2 FLWPILGVEFLVAVLGNGLALWLFVTRERRPWHTGVVFSfNLAVSDLLYALSLPLLAAYYYPPKNWRFGEAACKLERFLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPmdMQTSGVVLWTSLKAV--GIWVVSVLLAVPEAVFSEVAR--------IGSSDNS 193
Cdd:cd15376    82 TCNLYGSIFFITCISLNRYLGIVHP--FFTRSHVRPKHAKLVslAVWLLVAALSAPVLSFSHLEVerhnktecLGTAVDS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 194 SFTACIPYpqtdelhpkihSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEynehtkkqmetRKRLAKIVLVFVG 273
Cdd:cd15376   160 RLPTYLPY-----------SLFLAVVGCGLPFLLTLASYLAIVWAVLRSPGITTLE-----------KRKVAALVAVVVA 217
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958642650 274 CFVFCWFPNHIL---YLYRSFNYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKhfnsqLCCG 342
Cdd:cd15376   218 LYAVSFVPYHILrnlNLYRRLQWLKAAASLRIYFAYQVTKGLVTLNMCIHPLLYMAVADSIRL-----CCCG 284
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
52-335 8.64e-11

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 62.01  E-value: 8.64e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSV 131
Cdd:cd15066     8 LIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFSTASI 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 132 FTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLA-VPeaVFSE--------VARIGSSDNSSFTAcipyp 202
Cdd:cd15066    88 LHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISfLP--IFLGwytteehlQYRKTHPDQCEFVV----- 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 203 qtdelhPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRsahnlpgeynEHtkkqmetrkRLAKIVLVFVGCFVFCWFPn 282
Cdd:cd15066   161 ------NKIYALISSSVSFWIPCIVMIFTYYRIYLEAKR----------EH---------KAAKTLGIIMGAFILCWLP- 214
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 283 hILYLYRSFNYKEIDPSLGHMIVTLVARVLSFsNSCVNPFALYLLSESFRKHF 335
Cdd:cd15066   215 -FFLWYVTTTLCGDACPYPPILVSILFWIGYF-NSTLNPLIYAYFNRDFREAF 265
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
49-335 1.06e-10

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 61.56  E-value: 1.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFF-DEWVFGKLGCKLIPAIQLTSV 127
Cdd:cd15052     6 LLLLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTELFgGVWPLPLVLCLLWVTLDVLFC 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFsevARIGSSDNSSFTACIPypqtdel 207
Cdd:cd15052    86 TASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPIPVL---GIIDTTNVLNNGTCVL------- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 208 hPKIHSVLI-FLVYFLIPLVIISIYYyhiAKTlIRSAHNlpgeynehtkkqmetRKRLAKIVLVFVGCFVFCWFPNHILY 286
Cdd:cd15052   156 -FNPNFVIYgSIVAFFIPLLIMVVTY---ALT-IRLLSN---------------EQKASKVLGIVFAVFVICWCPFFITN 215
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1958642650 287 LYRSFNyKEIDPSLGHMIVTLVARvLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15052   216 ILTGLC-EECNCRISPWLLSVFVW-LGYVSSTINPIIYTIFNKTFRRAF 262
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
45-335 1.63e-10

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 61.51  E-value: 1.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRS-VPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLgCKLIPAIQ 123
Cdd:cd15319     2 VTGCLLSLLILWTLLGNILVCAAVVRFRHLRSkVTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAF-CDVWVAFD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLA-VPEAVF---SEVARIGSSDNSSfTACI 199
Cdd:cd15319    81 IMCSTASILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISfIPVQLNwhkDSGDDWVGLHNSS-ISRQ 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 200 PYPQTDELHPKIHSVLIFLVYFLIPLVIISIYY---YHIAKTLIRSAHNLP-------------GEYNEHTKKQMETRK- 262
Cdd:cd15319   160 VEENCDSSLNRTYAISSSLISFYIPVAIMIVTYtriYRIAQIQIRRISSLEraaehaqscrsnrIDCHHHTSLRTSIKKe 239
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958642650 263 -RLAKIVLVFVGCFVFCWFPNHILYLYRSF-NYKEIDPSLGHMIVTL----VARVLSFSNSCVNPFaLYLLSESFRKHF 335
Cdd:cd15319   240 tKVLKTLSVIMGVFVCCWLPFFILNCMVPFcDRPPADPDAGLPCVSEttfdVFVWFGWANSSLNPI-IYAFNADFRKVF 317
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
47-327 2.02e-10

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 60.96  E-value: 2.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  47 PSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVP-VDasrYFF--DEWVFGKLGCKLIPAIQ 123
Cdd:cd15366     4 PTLYIIVIVLGLPTNCLALWAAYLQVRQRNELGVYLLNLSVSDLLYIATLPLwID---YFLhrDNWIHGPESCKLFGFIF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARigssDNSSFTACI-PYP 202
Cdd:cd15366    81 YTNIYISIAFLCCISVDRYLAVAHPLRFAKVRRVKTAVAVSAVVWAIEIGANSAPLFHDELFR----DRYNHTFCFeKYP 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 203 QTDELhpKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAhnlpgeynehtKKQMETRKRLAKIVLVFVGCFVFCWFPN 282
Cdd:cd15366   157 MEDWV--AWMNLYRVFVGFLFPWVLMLFSYRGILRAVRGNV-----------STEQQEKAKIKRLALSLIAIVLLCFAPY 223
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1958642650 283 HILYLYRSFNY--KEIDPSLGHMIVTLVARVLSFSN-SCVNPFALYLL 327
Cdd:cd15366   224 HVLLLSRSVVYlgKPCDCGFEERVFTAYHVSLALTSlNCVADPILYCL 271
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
46-333 2.20e-10

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 61.00  E-value: 2.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  46 IPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLlllltCVPVDASRYFFDEWVFGKLG---CKLIPAI 122
Cdd:cd15171     3 VPQLCSAVFLVGLLDNGLVVFILVKYKGLKHVENIYFLNLAVSNL-----CFLLTLPFWAHAAWHGGSLGnptCKVLVAL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 123 QLTSVGVSVFTLTALSADRYRAIVNPMDMQTSG-VVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACIPY 201
Cdd:cd15171    78 SSVGLHSEALFNVLLTVQASRVFFHGRLASSARrVAPCGIIASVLAWLTAFLVTLPEFVFYKPQMDSQKSKCAFSRPHFL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 202 PQTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLirsahnlpgeynehtkKQMETRKRLAKIVLVFVGCFVFCWFP 281
Cdd:cd15171   158 PAEETFWKYFLTLKMNIVVLVFPLLVFIICCVQLRKTQ----------------RFRERQRDLSKLVFAIMVVFLLMWAP 221
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958642650 282 NHILYLYRSFnyKEIDP-----SLGHMIVTL-VARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15171   222 YNIALFLSAF--KEHFSlrdckSSYHLDASVqVTKLIATTHCCVNPLLYALLDPAFRR 277
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
49-321 2.91e-10

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 60.55  E-value: 2.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFF-DEWVFGKLGCKLIPAIQLTSV 127
Cdd:cd15212     6 VLLAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSrPGWLFGDRLCLANGFFNACFG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNP----MDMQTSGVVLwtslkaVGIWVVSVLLAVPEAVFS----EVARIGssdnssFTAC- 198
Cdd:cd15212    86 IVSTLTMTLISFDRYYAIVRQpqgkIGRRRALQLL------AAAWLTALGFSLPWYLLAsapeYYEKLG------FYHCl 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 199 -IPYPQTDELHPKIHSVLIFLVYfLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFVF 277
Cdd:cd15212   154 yVLHSGPSRLGAAYSSVLIVLCY-LLPFALMCFCHYNICKTVRLSESRVRPVTTYAHLLRFYSEMRTATTVLIMIVFIIC 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1958642650 278 CWFPNHILYLYRSFNYKEIDPSLghmivTLVARVLSFSNSCVNP 321
Cdd:cd15212   233 CWGPYCLLGLVAAAGGYQFPPLM-----DTVAIWMAWANGAINP 271
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
50-322 3.77e-10

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 60.40  E-value: 3.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  50 YLIIISVGLLGNI-MLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd15382     7 YSVLFLIAAVGNLtVLLILLRNRRRKRSRVNILLMHLAIADLLVTFIMMPLEIGWAATVAWLAGDFLCRLMLFFRAFGLY 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPMDM----QTSGVVLWTSlkavgiWVVSVLLAVPEAVFSEVARIGSSDNssFTACIPY--- 201
Cdd:cd15382    87 LSSFVLVCISLDRYFAILKPLRLsdarRRGRIMLAVA------WVISFLCSIPQSFIFHVESHPCVTW--FSQCVTFnff 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 202 PQTDelHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTKKQMETR----------KRLAKIVLVF 271
Cdd:cd15382   159 PSHD--HELAYNIFNMITMYALPLIIIVFCYSLILCEISRKSKEKKEDVSEKSSSVRLRRssvgllerarSRTLKMTIVI 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958642650 272 VGCFVFCWFPNHIL---YLYRSFNYKEIDPSLGHMIVTlvarvLSFSNSCVNPF 322
Cdd:cd15382   237 VLVFIICWTPYFIMslwYWFDRESASKVDPRIQKGLFL-----FAVSNSCMNPI 285
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
40-335 3.92e-10

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 60.15  E-value: 3.92e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  40 LVIRCVIPSLYLIIISvgllGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLI 119
Cdd:cd15317     1 VIIYIVLVLAMLITVS----GNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFH 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 120 PAIQLTSVGVSVFTLTALSADRYRAIVNP------MDMQTSGVVLWTSLKAVGIWVVSVLlavpeavFSEVARIGSSDNS 193
Cdd:cd15317    77 TGLDLLLCTTSIFHLCFIAIDRYYAVCDPlrypskITVQVAWRFIAIGWLVPGIYTFGLI-------YTGANDEGLEEYS 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 194 SFTACIPYPQTdeLHPKIHSVLIFLVYFLIPLVIISIY--YYHIAKTLIRSAHNLPGEYN---EHTKKQMETRKR-LAKI 267
Cdd:cd15317   150 SEISCVGGCQL--LFNKIWVLLDFLTFFIPCLIMIGLYakIFLVARRQARKIQNMEDKFRsseENSSKASASRERkAAKT 227
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 268 VLVFVGCFVFCWFPnhilylyrSFNYKEIDPSLGHMIVTLVARV---LSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15317   228 LAIVMGIFLFCWLP--------YFIDTIVDEYSNFITPAIVFDAviwLGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
45-335 4.00e-10

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 60.26  E-value: 4.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIF---ISNLAAGDLLLLLTCVPVDASRY--FFDEWVFGKLGCKLI 119
Cdd:cd15356     2 LFTAVYALIWALGAAGNALTIHLVLKKRSLRGLQGTVhyhLVSLALSDLLILLISVPIELYNFvwFHYPWVFGDLVCRGY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 120 PAIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEA-VFSEVARIGSSD---NSSF 195
Cdd:cd15356    82 YFVRDICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFALPMAfIMGQKYELETADgepEPSS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 196 TACIPYPQTDELhpKIHSVLIFLVYFLIPLVIISIYYYHIAKTLirsahnlpgeynehtkkQMETRKRLAKIVLVFVGCF 275
Cdd:cd15356   162 RVCTVLVSRATL--KVFIQVNAFVSFVLPLALIAFLNGVTVSHL-----------------RIQSLQHSVQVLRAIVIAY 222
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958642650 276 VFCWFPNHILYLYrsFNYKEIDPSLGHM-----IVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15356   223 VICWLPYHARRLM--FCYVPDDAWTDSLynfyhYFYMLTNTLFYVSSAVNPLLYNVVSSSFRKLF 285
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
45-333 5.40e-10

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 59.86  E-value: 5.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPnIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15149     2 VIPVFYSLVFIVGILLNGVNFWIFFYVPSNKSFI-VYLKNIVFADLLMSLTFPFKILSDVELGPWQLNVIVCRYSAVIFY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEvariGSSDNSSFTACIPYpqT 204
Cdd:cd15149    81 LNMYVGIIFFGLIGFDRYYKIVKPLHTSFVQNVGYSKALSVVVWMLMAVLSVPNIILTN----QSFHEANYTKCARL--K 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHPKIH--SVLIFLVYFLIPLVIISIYYYHIAKTLIRSahnlpgeYNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPN 282
Cdd:cd15149   155 SELGIQWHkaSNYICVSIFWVVFLLLIIFYVAISRKIYKS-------NQKFRRNSTNMKAKSSRNIFSILFVFFVCFVPY 227
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958642650 283 HILYLYRSFNYKEIDPSLGHMIVTLVAR----VLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15149   228 HALRIPYTLSQTGADYSCQSKTILYYMKeftlLLSAANVCLDPIIYFFLCQPFRE 282
PHA03235 PHA03235
DNA packaging protein UL33; Provisional
27-335 5.42e-10

DNA packaging protein UL33; Provisional


Pssm-ID: 223017 [Multi-domain]  Cd Length: 409  Bit Score: 60.60  E-value: 5.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  27 NDFLPDSDGTTAelvIRCVIPSLYLIIISVGL-LGNIMLVKIFLTNSTMR-SVPNIFISNLAAGDLLLLLTCVPVDASry 104
Cdd:PHA03235   19 NDTCVPTEGLSA---ARTTETFINLLIISVGGpLNLIVLVTQLLANRVHGfSTPTLYMTNLYLANLLTVFVLPFIMLS-- 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 105 ffDEWVFGK--LGCKLIPAIQLTSVGVSVFTLTALSADRYRaIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFS 182
Cdd:PHA03235   94 --NQGLLSGsvAGCKFASLLYYASCTVGFATVALIAADRYR-VIHQRTRARSSAYRSTYKILGLTWFASLICSGPAPVYT 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 183 EVARIGSSDNSS--FTACIPYPQTDELHPKIHS--VLIFLVYFLIPLVIISIYYYHIAKTLIRSAHnlpgeynehtKKqm 258
Cdd:PHA03235  171 TVVAHDDVDPEApgYETCVIYFRADQVKTVLSTfkVLLTLVWGIAPVVMMTWFYTFFYRTLKRASY----------KK-- 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 259 etRKRLAKIVLVFVGCFVFCWFPNHILYLYRSFNYKEIDPSLGHM----IVTLVARVLSFSNSCVNPFALYLLSESFRKH 334
Cdd:PHA03235  239 --RSRTLTFVCILLLSFLCLQTPFVAIMIFDSYATLIWPSDCEHInlrdAVSTLSRLVPNLHCLLNPILYAFLGNDFLKR 316

                  .
gi 1958642650 335 F 335
Cdd:PHA03235  317 F 317
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
40-335 5.88e-10

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 59.59  E-value: 5.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  40 LVIRCVIPSLYLIIIsvglLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLI 119
Cdd:cd15297     1 VFIVLVAGSLSLVTI----IGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLW 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 120 PAIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVArIGSSDNSSFTACI 199
Cdd:cd15297    77 LALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFI-VGGRTVPEGECYI 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 200 PYPQtdelhpkiHSVLIF---LVYFLIPLVIISIYYYHIAKTLIRsahnlpgeynehtkkqmetRKRLAKIVLVFVGCFV 276
Cdd:cd15297   156 QFFS--------NAAVTFgtaIAAFYLPVIIMTVLYWQISRASSR-------------------EKKVTRTILAILLAFI 208
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958642650 277 FCWFPNHILYLYRSFNYKEIDPSlghmiVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15297   209 ITWTPYNVMVLINTFCASCIPNT-----VWTIGYWLCYINSTINPACYALCNATFKKTF 262
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
49-341 6.24e-10

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 59.58  E-value: 6.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd15307     6 LALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPeavfseVARIGSSDNSSF----TACIPYPqt 204
Cdd:cd15307    86 ASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLP------LSLMYSKDHASVlvngTCQIPDP-- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 delhpkIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSahnlpgeyNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNHI 284
Cdd:cd15307   158 ------VYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQ--------RSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFV 223
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642650 285 LYLYRSFNyKEIDPSLGHMIVTLVARvLSFSNSCVNPFALYLLSESFRKHFNSQLCC 341
Cdd:cd15307   224 LNLLPTVC-AECEERISHWVFDVVTW-LGYASSMVNPIFYTIFNKVFRQAFKKVLLC 278
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
45-333 1.00e-09

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 59.03  E-value: 1.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVpNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15969     2 VFPVLYLIIFIGSILLNGLAVWIFFHIRNKTSF-IFYLKNIVIADLLMTLTFPFKIIQDSGLGPWNFNFFLCRYTSVLFY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEvariGSSDNSSFTACIPYPQT 204
Cdd:cd15969    81 ASMYTSIVFLGLISLDRYLKVVKPFGDSRMYSITFTKVLSACVWLIMAFLSLPNIILTN----GQPTEDNIHDCSKLKSP 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 deLHPKIHSVLIFL--VYFLIPLVIISIYYYHIAKTLIRSahnlpgeyNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPN 282
Cdd:cd15969   157 --LGVKWHTAVSYIniCIFVAVLVILIVCYISISRYIYKS--------SKQFISSSSRTRKHNQSIRVVVAVFFVCFLPY 226
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642650 283 HILYLYrsFNYKEIDPSLGHMIVTLVARV------LSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15969   227 HLCRIP--FTFSQLDKILDCTIKTILYYCkeatlfLSACNVCLDPIIYFFMCRSFSQ 281
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
116-333 1.10e-09

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 58.73  E-value: 1.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 116 CKLIPAIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLwTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSsf 195
Cdd:cd15965    80 CQLVGSLAILSTEVSVLLLTYLTLEKYICIVYPFRCLTPGKCR-TITILILIWIIGFIIAFIPLSNKEFFRNYYGTNG-- 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 196 tACIPY--PQTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAhNLPGEYNEHTKKQMETRKRLAKIVLVfvg 273
Cdd:cd15965   157 -VCFPLhsEQPESTGAQIYSVVIFLGLNLAAFIIIVFSYGSMFYSIHQTA-IMATEISNHIKKEMTLAKRFFFIVFT--- 231
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 274 cFVFCWFPNHILYLYrSFNYKEIDPSLGHMIVTLVARVlsfsNSCVNPFALYLLSESFRK 333
Cdd:cd15965   232 -DALCWIPIFILKLL-SLLQVEIPGTISSWVVIFILPI----NSALNPILYTLTTRPFKE 285
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
48-331 2.04e-09

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 58.04  E-value: 2.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  48 SLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDAsrYFFDEWVFGKLGCKLIPAIQLTSV 127
Cdd:cd15164     5 IIYIPILFFGLLFNVLALWVFCCKMKKWTETRVYMINLAVADCCLLFS-LPFVL--YFLKHSWPDDELCLVLQSIYFINR 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPMDMQTsgvvLWTSLKAVGI----WVVsvllavpeaVFSEVARIGSSDNSSFTACIpypQ 203
Cdd:cd15164    82 YMSIYIITAIAVDRYIAIKYPLKAKS----LRSPRKAALTcgllWVL---------VIISVSLRLAWEEQEENFCF---G 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEynehtKKQMetrKRLAKIVLVFVGCFVFCWFPNH 283
Cdd:cd15164   146 KTSTRPSKRTLIFSLLGFFIPLIILSFCSIQVIRSLKKKKKTNPHE-----EKLI---QKAIYIVSANLIVFIVCFLPLH 217
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 284 ILYLYRSF-NYKEIDPSL--GHMIVTLVARVLSFSNSCVNPFALYLLSESF 331
Cdd:cd15164   218 IGLLVRFVmESNKASCSLiqNIRNFIYVASCLANANCCLDAICYYFVAKEF 268
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
79-335 2.92e-09

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 57.56  E-value: 2.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  79 NIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSVFTLTALSADRYRAIVNPM----DMQTS 154
Cdd:cd15055    36 NLLLLSLAVADFLVGLLVMPFSMIRSIETCWYFGDTFCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLlyptKITIR 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 155 GVVLWTSLkavgIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACIpypqtdELHPKIHSVLIFLVYFLIPLVIISIYYYH 234
Cdd:cd15055   116 RVKICICL----CWFVSALYSSVLLYDNLNQPGLIRYNSCYGECV------VVVNFIWGVVDLVLTFILPCTVMIVLYMR 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 235 I---AKTLIRSAHNLP-GEYNEHTKKQMETRKRL--AKIVLVFVGCFVFCWFPNHILYLyrsfnykeIDPSLGH-MIVTL 307
Cdd:cd15055   186 IfvvARSQARAIRSHTaQVSLEGSSKKVSKKSERkaAKTLGIVVGVFLLCWLPYYIVSL--------VDPYISTpSSVFD 257
                         250       260
                  ....*....|....*....|....*...
gi 1958642650 308 VARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15055   258 VLIWLGYFNSCLNPLIYALFYPWFRKAL 285
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
41-335 3.67e-09

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 56.98  E-value: 3.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  41 VIRCVIpsLYLIIISVgLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIP 120
Cdd:cd15331     1 VLTSII--LGLLILAT-IIGNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMPLSAVYEVSQHWFLGPEVCDMWI 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 121 AIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVgIWVVSVLLAVPeavfsevARIGSSDNSSFTAciP 200
Cdd:cd15331    78 SMDVLCCTASILHLVAIALDRYWAVTNIDYIRRRTAKRILIMIAV-VWFVSLIISIA-------PLFGWKDEDDLDR--V 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 201 YPQTDELHPKIHSVLIF--LVYFLIPLVIISIYYYHIAKTLIRsahnlpgeynehtkkqmetRKRLAKIVLVFVGCFVFC 278
Cdd:cd15331   148 LKTGVCLISQDYGYTIFstVGAFYVPLLLMIIIYWKIYQAAKR-------------------ERKAARTLAIITGAFVVC 208
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642650 279 WFPNHILYLYRSFNYKEIDPSLGHMIVTLvarvLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15331   209 WLPFFLVALVMPFCGAWQISRFLESFFLW----LGYFNSLLNPIIYTIFSPDFRGAF 261
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
109-335 4.18e-09

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 57.06  E-value: 4.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 109 WVFGKLGCKLIPAIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIg 188
Cdd:cd15119    65 WPFGVWLCKINSFVAVLNMFASVLFLTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAISGPALYFRDTMEL- 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 189 ssdNSSFTACIP--YPQTDELHPKIHSVLI---FLVYFLIPLVIISIYYYHIAKTLIRsahnlpgeynehtkKQMETRKR 263
Cdd:cd15119   144 ---SINVTICFNnfHKHDGDLIVMRHTILVwvrFFFGFLFPLLTMVVCYSLLAIKVKR--------------RTLLISSK 206
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642650 264 LAKIVLVFVGCFVFCWFPNHILYL-----YRSFNYKEIdpsLGHMIVtlVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15119   207 FFWTISAVIVAFFVCWTPYHIFSIlelsiHHSSYLHNV---LRAGIP--LATSLAFINSCLNPILYVLIGKKFKAHL 278
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
58-333 4.56e-09

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 56.79  E-value: 4.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  58 LLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSVFTLTAL 137
Cdd:cd15318    15 VLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHLCFI 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 138 SADRYRAIVNPMdMQTSGVVLWTSLKAVGI-WVVSVLLAvPEAVFSEVARIGSSDNSSFTACIPYPQTdeLHPKIHSVLI 216
Cdd:cd15318    95 SIDRHCAICDPL-LYPSKFTIRVACIFIAAgWLVPTVYT-SVFLYTKAVEEGLAELLTSVPCVGSCQL--LYNKLWGWLN 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 217 FLVYFLIPLVIISIY--YYHIAKTLIRSAHNLPGEYNEHTKKQmetrKRLAKIVLVFVGCFVFCWFPNHILYLYRSF-NY 293
Cdd:cd15318   171 FPVFFIPCLIMIGLYvkIFIVAKRQARAIASLLSDTNGASKRE----RKAAKTLGIAVGVYLLCWLPFTIDTMVDSLlNF 246
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1958642650 294 keIDPSLGHMIVTLVArvlsFSNSCVNPFALYLLSESFRK 333
Cdd:cd15318   247 --ITPPLLFDIIIWFA----YFNSACNPLIYVFSYPWFRK 280
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
50-333 4.70e-09

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 57.18  E-value: 4.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  50 YLIIISVGllGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGV 129
Cdd:cd15316     9 FGAVLAVF--GNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTCCDVSFCYA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 130 SVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVpEAVFSEVARIGSSDNSSFTACIPYPQTdeLHP 209
Cdd:cd15316    87 SLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIFSLTYSF-SVFYTGVNDDGLEELVNALNCVGGCQI--ILN 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 210 KIHSVLIFLVYFLIPLVIISIY--YYHIAK---TLIRSAHNLPGEYNEHTKKQMETRKR-LAKIVLVFVGCFVFCWFPNH 283
Cdd:cd15316   164 QNWVLVDFLLFFIPTFAMIILYgkIFLVAKqqaRKIEMTSSKAESSSESYKDRVARRERkAAKTLGITVIAFLVSWLPYL 243
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 284 ILYLyrsfnykeIDPSLGHMIVTLVARVL---SFSNSCVNPFALYLLSESFRK 333
Cdd:cd15316   244 IDVL--------IDAFMNFITPPYIYEICcwcAYYNSAMNPLIYALFYPWFRK 288
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
45-333 4.75e-09

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 57.07  E-value: 4.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPnIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15924     2 LFPVLYTVIFFAGILLNGLAMWIFFHIPSKSSFI-IYLKNTVVADLLMILTFPFKILSDAGLGPWQLRTFVCRVTSVLFY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEvariGSSDNSSFTACIPYpqT 204
Cdd:cd15924    81 FTMYTSIVFLGLISIDRYLKIVRPFKTSFPKSVSFAKILSVVVWALMFLLSLPNMILTN----QQPREKNVKKCSFL--K 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHPKIHSVL--IFLVYFLIPLVIISIYYYHIAKTLIRSahnlpgeYNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPN 282
Cdd:cd15924   155 SELGLKWHEIVnyICQVIFWIVFLLMIVCYTAITKKVYRS-------YRRVFRSSSSRRKKSNVKIFIIVAVFFVCFVPY 227
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958642650 283 HILYLYRSFNYKEIDPSLGHMIVTLVAR----VLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15924   228 HFARIPYTLSQTRDVFDCTAENILFYVKeatlFLSALNVCLDPIIYFFLCKSFRE 282
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
49-333 5.73e-09

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 56.76  E-value: 5.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLG---NIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLT 125
Cdd:cd15078     3 LALLIATIGFLGvcnNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRGRWVFDVAGCVWDGFSNSL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 126 SVGVSVFTLTALSADRYRAIVNPMDMQTSgvvlWTSLKAVGIWVVSV------LLAVPEAVFsEVARIGSSdnssftacI 199
Cdd:cd15078    83 FGIVSIMTLTVLAYERYIRVVHAKVVNFS----WSWRAITYIWLYSLawtgapLLGWNRYTL-EVHGLGCS--------F 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 200 PYPQTDelhPKIHS--VLIFLVYFLIPLVIISIYYYHIAKT--LIRSAHNLPgeyNEHTKKQMETRKRLAKIVLVFVGCF 275
Cdd:cd15078   150 DWKSKD---PNDTSfvLLFFLGCLVVPLGIMAYCYGHILYEirMLRSVEDLQ---TFQVIKILKYEKKVAKMCLLMISTF 223
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958642650 276 VFCWFPNHILYLYRSFNYKE-IDPSlghmiVTLVARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15078   224 LICWMPYAVVSLLVTSGYSKlVTPT-----IAIIPSLFAKSSTAYNPVIYIFMIRKFRQ 277
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
56-333 6.33e-09

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 56.45  E-value: 6.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  56 VGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDL-----LLLLTCVPVDASRYFFD---EWVFGKlGCKLIPAIQLTSV 127
Cdd:cd15964    13 LAILGNVFVLLILLTSHYKLTVPRFLMCNLAFADFcmgiyLLLIASVDLHTRSEYYNhaiDWQTGP-GCNTAGFFTVFAS 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVpeavfseVARIGSSDNSSFTACIPYpQTDEL 207
Cdd:cd15964    92 ELSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGGWVFCFLLAL-------LPLVGVSSYAKVSICLPM-DTETP 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 208 HPKIHSVLIfLVYFLIPLVIISIYYYHIAKTlIRSAHNLPGEynehtkKQMETRKRLAkiVLVFVGcfVFCWFPNHILYL 287
Cdd:cd15964   164 LAQAYIVFV-LMLNIIAFVIICACYIKIYIT-VRNPQYKSGD------KDTKIAKRMA--VLIFTD--FICMAPISFYAL 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1958642650 288 YRSFNYKEIDPSLGHMIVTLVARVlsfsNSCVNPFALYLLSESFRK 333
Cdd:cd15964   232 SAILNKPLITVSNSKILLVLFYPL----NSCANPFLYAIFTKAFRR 273
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
48-332 6.48e-09

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 56.21  E-value: 6.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  48 SLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIPAIQLTSV 127
Cdd:cd15072     5 SILLVEALVGFSLNGLTILSFCKTRELRTPSNLLVLSLAVADMGISLN-ALVAASSSLLRRWPYGSEGCQAHGFQGFFTA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLkavgIWVVSVLLA-VPEAVFS----EVARigssdnssfTAC-IPY 201
Cdd:cd15072    84 LASICSSAAIAWDRYHHYCTRSKLQWSTAISLVLF----VWLFSAFWAaMPLLGWGeydyEPLG---------TCCtLDY 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 202 PQTDElhpKIHSVLIFLV--YFLIPLVIISiyyyhiakTLIRSAHNlpgeyneHTKKQmetrKRLAKIVLVFVGCFVFCW 279
Cdd:cd15072   151 SKGDR---NYVSYLFTMAffNFILPLFILL--------TSYSSIEQ-------KLKKE----GHLRFNTGLPLLTLLICW 208
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958642650 280 FPNHILYLYRSF-NYKEIDPSLGHmivtlVARVLSFSNSCVNPFALYLLSESFR 332
Cdd:cd15072   209 GPYAILALYAAItDVTSISPKLRM-----VPALLAKTSPTINAILYALGNENYR 257
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
45-335 6.75e-09

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 56.37  E-value: 6.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15301     2 LIVIVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAV---FSEVARIGSSDnssftACipY 201
Cdd:cd15301    82 LASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLLLWPPWIYswpYIEGKRTVPAG-----TC--Y 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 202 PQTDELHPKIhSVLIFLVYFLIPLVIISIYYYHIaktlirsahnlpgeYNEHTKKQMETRKRLAKIVLVFVGCFVFCWFP 281
Cdd:cd15301   155 IQFLETNPYV-TFGTALAAFYVPVTIMCILYWRI--------------WRETKKRQKKQESKAAKTLSAILLAFIVTWTP 219
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958642650 282 NHILYLYRSFNykEIDPSLGHMIVTLVaRVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15301   220 YNVLVLIKAFF--PCSDTIPTELWDFS-YYLCYINSTINPLCYALCNAAFRRTY 270
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
49-321 7.87e-09

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 56.40  E-value: 7.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd15403     6 VMILMIAIGFLGNAIVCLIVYQKPAMRSAINLLLATLAFSDIMLSLLCMPFTAVTIITVDWHFGAHFCRISAMLYWFFVL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPMDMQTSGVvlwTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSdnssftacipYPQ----- 203
Cdd:cd15403    86 EGVAILLIISVDRFLIIVQRQDKLNPHR---AKVMIAISWVLSFCISFPSVVGWTLVEVPAR----------APQcvlgy 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSA---HN-----------------LPGEYNEHTKKQMETRKr 263
Cdd:cd15403   153 TESPADRVYAVLLVVAVFFVPFSIMLYSYLCILNTVRRNAvriHNhadslclsqvsklglmgLQRPHQMNVDMSFKTRA- 231
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958642650 264 LAKIVLVFVGcFVFCWFPNHILYLYRSFNYKEIDPSLGHMIVTLVARvLSFSNSCVNP 321
Cdd:cd15403   232 FTTILILFVG-FSLCWLPHTVFSLLSVFSRRFYYSSSFYPISTCVLW-LSYLKSVFNP 287
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
56-335 8.57e-09

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 55.80  E-value: 8.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  56 VGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSVFTLT 135
Cdd:cd15298    13 VTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLL 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 136 ALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSE--VARIGSSDNSSFTACIPYPQTdelhpkihS 213
Cdd:cd15298    93 IISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQfvVGKRTVPDNQCFIQFLSNPAV--------T 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 214 VLIFLVYFLIPLVIISIYYYHIAKTLIRsahnlpgeynehtkkqmetRKRLAKIVLVFVGCFVFCWFPNHILYLYRSFNY 293
Cdd:cd15298   165 FGTAIAAFYLPVVIMTVLYIHISLASAR-------------------ERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQ 225
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1958642650 294 KEIDPSlghmiVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15298   226 SCIPDT-----VWSIGYWLCYVNSTINPACYALCNATFKKTF 262
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
51-335 5.12e-08

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 53.69  E-value: 5.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  51 LIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVdasrYFFDE-----WVFGKLGCKLIPAIQLT 125
Cdd:cd15308     8 VLLILAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPL----YVYSEfqggvWTLSPVLCDALMTMDVM 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 126 SVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPeaVFSEVARIGSSDnssftacipyPQTD 205
Cdd:cd15308    84 LCTASIFNLCAISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSFAVASP--VIFGLNNVPNRD----------PAVC 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 206 ELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSahnlpgeynehtKKQMetrkrlaKIVLVFVGCFVFCWFPNHIL 285
Cdd:cd15308   152 KLEDNNYVVYSSVCSFFIPCPVMLVLYCAMFRGLGRE------------RKAM-------RVLPVVVGAFLFCWTPFFVV 212
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958642650 286 YLYRSFNYKEIDPSLGHMIVTLvarvLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15308   213 HITRALCESCSIPPQLISIVTW----LGYVNSALNPVIYTVFNAEFRNVF 258
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
49-333 7.03e-08

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 53.23  E-value: 7.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRS-VPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSV 127
Cdd:cd15219     5 LLVVVLVVSLLSNLLVLLCFLYSAELRKqVPGIFLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLETFLT 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARigSSDNSSFTACIPyPQTDEL 207
Cdd:cd15219    85 SNAMLSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSLTFSLVALFLSWLGY--SSLYASCTLHLP-REEERR 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 208 HPKIHSVLIFLVYFLIPLVIISIYYYHIAKtlirsahnlpgeynehtkkqMETRKRLAKIVLVFVGCFVFCWFPNHILYL 287
Cdd:cd15219   162 RFAVFTAFFHAFTFLLSLLVLCVTYLKVLK--------------------VRRRQRATKKISIFIGTFVLCFAPYVITRL 221
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1958642650 288 YRSFNYKEIDPSLGhmivtLVARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15219   222 VELLPFVTINRYWG-----IVSKCLTYSKAASDPFVYSLLRQQYRK 262
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
52-335 7.74e-08

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 53.20  E-value: 7.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSV 131
Cdd:cd15086     9 FILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVCVLGTPFSFAASTQGRWLIGEHGCRWYGFANSLFGIVSL 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 132 FTLTALSADRYRAIVNPMDMQTSGVVLwTSLKAVGIWVVSVLLAVPEAV-FSEVARIGSSdnssfTACIPYPQTDELHPK 210
Cdd:cd15086    89 ISLAVLSYERYCTLLRPTEADVSDYRK-AWLGVGGSWLYSLLWTLPPLLgWSSYGPEGPG-----TTCSVQWTSRSANSI 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 211 IHSVLIFLVYFLIPLVIIsIYYYHIAKTLIRSAhnlpGEYNEHTKKQMETRKRLakIVLVFVGCFVFCWFPNHILYLYRS 290
Cdd:cd15086   163 SYIICLFIFCLLLPFLVM-VYCYGRLLYAIKQV----GKINKSTARKREQHVLL--MVVTMVICYLLCWLPYGVMALLAT 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1958642650 291 FNykeiDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15086   236 FG----KPGLVTPVASIVPSILAKSSTVVNPIIYVFMNKQFYRCF 276
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
49-341 8.14e-08

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 53.30  E-value: 8.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGllGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDE-WVFGKLGCKLIPAIQLTSV 127
Cdd:cd15306     8 LMVIIPTIG--GNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAmWPLPLVLCPIWLFLDVLFS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPeavfseVARIGSSDNSSFTACIPYPQTDEl 207
Cdd:cd15306    86 TASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLISIGIAIP------VPIKGIETDVDNPNNITCVLTKE- 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 208 hpKIHSVLIF--LVYFLIPLVIISIYYYHIAKTLirsahnlpgeynehTKKQMETRKRLAKIVLVFVGCFVFCWFPNHIL 285
Cdd:cd15306   159 --RFGDFILFgsLAAFFTPLAIMIVTYFLTIHAL--------------RKQTITNEQRASKVLGIVFFLFLLMWCPFFIT 222
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 286 YLyRSFNYKEIDPSLGHMIVTLVARVlSFSNSCVNPFALYLLSESFRKHFNSQLCC 341
Cdd:cd15306   223 NI-TSVLCDSCNQTTLQMLMEIFVWI-GYVSSGVNPLVYTLFNKTFRDAFGRYITC 276
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
52-328 8.52e-08

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 53.01  E-value: 8.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVGLLGNIM-LVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVD-ASRYFFD------EWVFGKLGCKLIPAIQ 123
Cdd:cd14980     9 IIGILALIGNILvIIWHISSKKKKKKVPKLLIINLAIADFLMGIYLLIIAiADQYYRGryaqysEEWLRSPPCLLACFLV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPM-----DMQTSGVVLwtslkaVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTAC 198
Cdd:cd14980    89 SLSSLMSVLMMLLITLDRYICIVYPFsnkrlSYKSAKIIL------ILGWLFSIIFAAIPILYSINQPGDNRLYGYSSIC 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 199 IPypqtdeLHPKIHSVLIFLVYFL----IPLVIISIYYYHIAKTLIRSAHNLpgeynehTKKQMETRKRLAK--IVLVFV 272
Cdd:cd14980   163 MP------SNVSNPYYRGWLIAYLlltfIAWIIICILYILIFISVRKSRKSA-------RRSSSKRDKRIAIrlALILIT 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 273 GCfvFCWFPNHILYLYRSFNYKEIDPSLGHMIVTLVARVlsfsNSCVNPFaLYLLS 328
Cdd:cd14980   230 DL--ICWLPYYIVIFSGLLTSTEIDIHVLQFIAILALPL----NSAINPY-LYTLT 278
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
53-177 1.28e-07

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 52.73  E-value: 1.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  53 IISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVP-VDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSV 131
Cdd:cd15218    10 IIGVSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPfVFTSVKNGSTWTYGTLTCKVIAFLGVLSCFHTA 89
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1958642650 132 FTLTALSADRYRAIVNpMDMQTSGVVLWTSLKAVG-IWVVSVLLAVP 177
Cdd:cd15218    90 FMLFCISVTRYLAIAH-HRFYTKRLTFWTCLAVICmVWTLSVAMAFP 135
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
108-335 1.40e-07

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 52.47  E-value: 1.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 108 EWVFGKLGCKLIPAIQLTSVGVSVFTLTALSADRYRAIVnpMDMQTSGVvlwtSLKAVGIWVVSVLLAVPEAVFSEVARI 187
Cdd:cd15364    65 KWPWGSLACKITGYIFFCNIYISILLLCCISIDRFVAVV--YALESRGR----RRQRIAAFISFLIFIVVGLVHSPVFIM 138
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 188 GSSDNSSFTACIPYPQTDELHPKIHSVLiFLVYFLIPLVIISIYYYHIAKTlIRSAHNLpgeynehTKKQMETRKRLAKI 267
Cdd:cd15364   139 REGQTEGSHTCFETLQMDTQVAGFYYAR-FCIGFAIPLAILIFTNYRIFRS-IQTSTSL-------TPHQKAKVKYLAIA 209
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 268 VLVFvgcFVFCWFPNHILYLYRSFNYKEIDPSLGHM---IVTLVARVLSFS--NSCVNPFALYLLSESFRKHF 335
Cdd:cd15364   210 VIVI---FLICFAPYHLVLLVRAIAFSLYPNGMCGFeerIYTPSVIFLCLStvNSVADPIIYVLVSENVRQDI 279
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
50-333 1.67e-07

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 52.03  E-value: 1.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  50 YLIIISVGLLGNIMLVKIFLT--NSTMRSVpnIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIPAIQLTSV 127
Cdd:cd15152     7 YTVILIPGLIGNVLALWVFYAyvKETKRAV--IFMINLAIADLLQVLS-LPLRIFYYLNKSWPFGKFLCMFCFYLKYVNM 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGiWVVSVLLAVPEAVFSEvarigsSDNSSFTAC---IPYPQT 204
Cdd:cd15152    84 YASIYFLVCISVRRCLYLIYPFRYNDCKRKCDVYISIAG-WLVVCVGCLPFPLLRQ------SQDTNPTCCfadLPLRNV 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLirsahnlpGEYNEHTKKQMETRKRLaKIVLVFVGCFVFCWFPNHI 284
Cdd:cd15152   157 GLTTSVIMLTIAELTGFVTPLLIVLYCSWKTVMSL--------REKTPVLQDLGEKKKAL-KMILTCAVVFLICFAPYHI 227
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 285 LY----LYRSFNYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15152   228 SFpldfLVKSNKIKSCTARKVILIFHPVALCLASLNSCLDPVIYYFTTDEFKR 280
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
107-290 2.04e-07

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 52.07  E-value: 2.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 107 DEWVFGKLGCKLIPAIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVAR 186
Cdd:cd15367    64 DNWTYSELLCKICGILLYENIYISIGFLCCISVDRYLAVVHPFRFHAFRTMKAATLVSTVIWLKELMTCVFFFLHGEISK 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 187 igssDNSSFTACIPYPQTDELHPKIHSVLiFLVYFLIPLVIISIYYYHIAKTLIRSAHNlpgeynehtkkQMETRKRLAK 266
Cdd:cd15367   144 ----DKENHSVCFEHYPIKAWEHNINYYR-FYAGFLFPIFLLSFSYCRILRAVRKSHGT-----------QKSQKIQIKR 207
                         170       180
                  ....*....|....*....|....
gi 1958642650 267 IVLVFVGCFVFCWFPNHILYLYRS 290
Cdd:cd15367   208 LVLSTVVIFLVCFGPYHILLLVRS 231
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
56-275 2.08e-07

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 51.69  E-value: 2.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  56 VGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLlTCVPVDASRYFFDE-WVFGKLGCKLIPAIQLTSVGVSVFTL 134
Cdd:cd15200    13 LGLVGNGIALFIFCFHRRPWKSNTMYLLSLVVADFFLI-INLPFRIDYYLRNEvWRFGATACQVNLFMLSMNRTASIVFL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 135 TALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPeaVFSevarigSSDNSSFTACIPY--PQTDELHPKIH 212
Cdd:cd15200    92 TAIALNRYLKVVHPHHQLSKASVGCAAKVAAGLWILILLLNIH--LLL------LDHVQSNSTCLSYdhGTDPSASDRWH 163
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 213 SVLIFLVYFLiPLVIISIYYYHIAKTLIRsaHNLPGEynehtKKQMETRKRLAKIVLVFVGCF 275
Cdd:cd15200   164 RILFFLEFFL-PLGIILFCIFSIILTLKQ--RKLAKQ-----AGPQRAVKVLAVIVLVYTVCF 218
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
50-332 2.92e-07

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 51.33  E-value: 2.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  50 YLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGV 129
Cdd:cd15153     7 YIIIFIPGLLANSAALWVLCRFISKKNKAIIFMINLAVADLAHVLS-LPLRIHYYIQHTWPFGRFLCLLCFYLKYLNMYA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 130 SVFTLTALSADRYRAIVNPMDMQTsgvvlWTSLKAVGI----WVVSVLLAVPEAVFSEVARigSSDNSSFTACIPYPQTD 205
Cdd:cd15153    86 SICFLTCISIQRCFFLLHPFKARD-----WKRRYDVGIsaavWIVVGLACLPFPLLRSKSL--SNNNRSCFADLGMKKLN 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 206 ELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLirsahnlpGEYNEHTKKQMETRKRLaKIVLVFVGCFVFCWFPNHIL 285
Cdd:cd15153   159 FGAAIAMMTVAELFGFVIPLFIIAWCTWKTENSL--------RQRNKQQQSTSEKQKAL-RMVRMCAAVFFICFAPYHIN 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 286 YLYRSFNYKEIDPSLGHMIVTL----VARVLSFSNSCVNPFALYLLSESFR 332
Cdd:cd15153   230 FLFYLMVSESIITNCEVSQVILqfhpISLCLASLNCCLDPILYYFMTSEFQ 280
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
52-333 3.18e-07

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 51.41  E-value: 3.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVG-LLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVD---ASRYFFDEWVFGKLGCKLIPAIQLTSV 127
Cdd:cd15006     7 VVIFVGsLLGNFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLVCVPFDivlSASPHCCWWIYTLLFCKVIKFLHKVFC 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPMDMQTSGVVlwTSLKAVGIWVVSVLLAVPEAVFSEVarigsSDNSSFTACIPYPQTDEL 207
Cdd:cd15006    87 SVTVLSFAAIALDRYYSVLYPLERKISDAK--SRDLVIYIWAHAVVASVPVFAVTNV-----TDIYAMSTCTESWGYSLG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 208 HpkihsvLIFLVYFLIPLVIISIYYYHIAKTLIRSAHN-----------LPGEYNEHTKKQMETRK-RLAKIVLVFVGCF 275
Cdd:cd15006   160 H------LVYVIIYNITTVILPVAVVFLFMILIRRALSasqkkkviiaaLRTPQNTISIPYVSQREaELHAMLLSMVLVF 233
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958642650 276 VFCWFPNHILYLYRS-FNYKEIDPSLghmivTLVARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15006   234 ILCSVPYATLVIYRTiLNISDISVFL-----LLTAIWLPKVSLLANPLLFLTVNKSVRK 287
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
45-337 3.40e-07

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 51.10  E-value: 3.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDE-WVFGKLGCKLIPAIQ 123
Cdd:cd15328     2 LVLTLLAMLVVATFLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRrWQLGRSLCQVWISFD 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSevarIGSSDNSSFTACipypQ 203
Cdd:cd15328    82 VLCCTASIWNVTAIALDRYWSITRHLEYTLRTRRRISNVMIALTWALSAVISLAPLLFG----WGETYSEDSEEC----Q 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDElHPKiHSVLIFLVYFLIPLVIISIYYYHIAKTlirsahnlpgeynehtkkqMETRKRLAKIVLVFVGCFVFCWFPNH 283
Cdd:cd15328   154 VSQ-EPS-YTVFSTFGAFYLPLCVVLFVYWKIYKA-------------------AQKEKRAALMVGILIGVFVLCWIPFF 212
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958642650 284 ILYLYRSFNYKEIDPslghmIVTLVARVLSFSNSCVNPfalyLLSESFRKHFNS 337
Cdd:cd15328   213 LTELISPLCSCDIPP-----IWKSIFLWLGYSNSFFNP----LIYTAFNKNYNN 257
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
52-177 7.05e-07

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 50.72  E-value: 7.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVP-VDASRYFFDEWVFGKLGCKLIPAIQLTSVGVS 130
Cdd:cd15217     9 LIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPfVLVSIRNGSAWTYSVLSCKIVAFMAVLFCFHA 88
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1958642650 131 VFTLTALSADRYRAIVNpMDMQTSGVVLWTSLKAVG-IWVVSVLLAVP 177
Cdd:cd15217    89 AFMLFCISVTRYMAIAH-HRFYSKRMTFWTCIAVICmVWTLSVAMAFP 135
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
49-335 8.69e-07

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 49.65  E-value: 8.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd15309     6 LLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMCT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPMDMQT--SGVVLWTSLKAVgIWVVSVLLAVPeavfsevaRIGSSDNSSFTACIpypqtde 206
Cdd:cd15309    86 ASILNLCAISIDRYTAVAMPMLYNTrySSKRRVTVMISV-VWVLSFAISCP--------LLFGLNNTDQNECI------- 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 207 LHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLirsahnlpgeynehtkkqmETRKRLAKIVLVFVGCFVFCWFPNHILY 286
Cdd:cd15309   150 IANPAFVVYSSIVSFYVPFIVTLLVYVQIYIVL-------------------QKEKKATQMLAIVLGVFIICWLPFFITH 210
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1958642650 287 LYRSFNYKEIDPSLGHMIVTlvarvLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15309   211 ILNMHCDCNIPPALYSAFTW-----LGYVNSAVNPIIYTTFNIEFRKAF 254
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
45-332 8.93e-07

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 49.78  E-value: 8.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQL 124
Cdd:cd15365     2 LFPFVYIFVIVISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYIVILPLWIDYLWNGDNWTLSGFVCIFSAFLLY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARigssDNSSFTACI-PYPQ 203
Cdd:cd15365    82 TNFYTSTALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLLEICFNAVILTWEDSFH----ESSSHTLCYdKFPL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 tdELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLirsahnlpgEYNEHTKKQmeTRKRLAKIVLVFVGCFVFCWFPNH 283
Cdd:cd15365   158 --EDWQARLNLFRICLGYLLPLLIILFCYWKIYQAV---------RSNQATEDQ--EKKKIFKLLLLITVTFVICFTPYH 224
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 284 ILYLYRSFnYKEIDPSLGHMIVTLVARVLSFS--NSCVNPFALYLLSESFR 332
Cdd:cd15365   225 VVLLIRSI-VEPCDCRNAKWLYTLYKITVALTslNCIADPFLYCFVTESGR 274
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
49-335 9.95e-07

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 49.58  E-value: 9.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVP-VDASRYFFDEWVFGKLGCKLIPAIQLTSV 127
Cdd:cd15310     6 SYCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPwVVYLEVTGGVWNFSRICCDVFVTLDVMMC 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPMDMQTS---GVVLWTSLKAVGIWVVSVLLAVPeavfsevARIGSSDNSSFTACipypqt 204
Cdd:cd15310    86 TASILNLCAISIDRYTAVVMPVHYQHGtgqSSCRRVSLMITAVWVLAFAVSCP-------LLFGFNTTGDPTVC------ 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 dELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRsahnlpgeynehtkkqmetRKRLAKIVLVFVGCFVFCWFPNHI 284
Cdd:cd15310   153 -SISNPDFVIYSSVVSFYLPFGVTLLVYVRIYVVLLR-------------------EKKATQMLAIVLGAFIVCWLPFFL 212
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958642650 285 LYLYRSFNYK-EIDPSLGHmivtlVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15310   213 THILNTHCQAcHVPPELYS-----ATTWLGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
48-335 1.74e-06

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 49.08  E-value: 1.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  48 SLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFgkLGCKLIPAIQLTSV 127
Cdd:cd15071     5 GIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIIINIGPQTEF--YSCLMVACPVLILT 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLA-VPEAVFSEVARIGSSDN--SSFTACIPYPQT 204
Cdd:cd15071    83 QSSILALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGlTPMFGWNNLNAVERAWAanSSMGELVIKCQF 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 205 DELHPKIHSVLI-FLVYFLIPLVIISIYY----YHIAKTLIRSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVgcfvFCW 279
Cdd:cd15071   163 ETVISMEYMVYFnFFVWVLPPLLLMLLIYlevfYLIRKQLNKKVSSSSSDPQKYYGKELKIAKSLALILFLFA----LSW 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 280 FPNHILYLYRSFNYKEIDPslghMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15071   239 LPLHILNCITLFCPSCKKP----MILTYIAIFLTHGNSAMNPIVYAFRIKKFRTTF 290
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
45-332 2.24e-06

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 48.70  E-value: 2.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCkLIPAIQL 124
Cdd:cd15085     2 ILSFLMFLNATFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFC-IFQGFAV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVG-VSVFTLTALSADRYRAIVNPMdmqtSGVVLWTSLKAVG---IWVVSVLLAV----------PEAVFSEVArIGSS 190
Cdd:cd15085    81 NYFGiVSLWSLTLLAYERYNVVCKPM----GGLKLSTKRGYQGllfIWLFCLFWAVaplfgwssygPEGVQTSCS-IGWE 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 191 DNS--SFTACIPYpqtdelhpkihsvliFLVYFLIPLVIISIYYYHIaktlIRSAHNLPGEYNEH-TKKQMETRKRLAKI 267
Cdd:cd15085   156 ERSwsNYSYLILY---------------FLMCFVIPVAIIGFSYGNV----LRSLHKLNKKIEQQgGKNCPEEEERAVIM 216
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958642650 268 VLVFVGCFVFCWFPNHILYLYRSFNYKEIDPSLGHMIVTLVARvlsfSNSCVNPFALYLLSESFR 332
Cdd:cd15085   217 VLAMVIAFLICWLPYTVFALIVVVNPELSISPLAATMPTYFAK----TSPVYNPIIYIFLNKQFR 277
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
49-335 2.71e-06

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 48.30  E-value: 2.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd15215     5 LIVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFAF 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVP------EAVFSEVARIGSSDNSSFTAcipyp 202
Cdd:cd15215    85 AGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPplygwgQAAFDERNALCSVIWGSSYS----- 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 203 qtdelhpkiHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNlpgeynehtkkqmetrkRLAKIVLVFVGCFVFCWFPN 282
Cdd:cd15215   160 ---------YTILSVVSSFVLPVIIMLACYSMVFRAARRCYHC-----------------KAAKVIFIIIFSYVLSMGPY 213
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 283 HILYLYRSFNYKEIDPslghmIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15215   214 SFLSVLAVWVDTQVPQ-----WVISIILWLFFLQCCIHPYIYGYMHKSIKKEF 261
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
49-335 2.73e-06

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 48.64  E-value: 2.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKI--FLTNS--TMRSVPNIFISnLAAGDLLLLLTCVPVDASRYFFD--EWVFGKLGCKLIPAI 122
Cdd:cd15135     6 LYSLILVAGILGNSATIKVtqVLQKKgyLQKSVTDHMVS-LACSDLLVLLLGMPVELYSAIWDpfATPSGNIACKIYNFL 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 123 QLTSVGVSVFTLTALSADRYRAIVNPMD---MQTSGVVLWTSLkavgIWVVSVLLAVP-------EAVFSEVARIGSSDN 192
Cdd:cd15135    85 FEACSYATILNVATLSFERYIAICHPFKykaLSGSRVRLLICF----VWLTSALVALPllfamgtEDPLEAFPSYRGTRH 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 193 ------SSFTACIPYPQTDELHpkIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRS-----AHNLPGEYNEHTKKQMETR 261
Cdd:cd15135   161 hcqdqkSNLTICTSLSSKWTVF--QASIFSAFVLYLLVLASVAFMCRRMMRALMGSkkgavAVKGPGGSVQLLRKHESAE 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 262 KRLA-KIVLVFVGCFV----FCWFPNHILYLYRSFNYKE---IDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15135   239 GKTArKQTILFLGLIVgtlaVCWMPNQIRRIMAAAKPKDdwtRSYFRAYIILLPIADTFFYLSSVLNPLLYNLSSQQFRS 318

                  ..
gi 1958642650 334 HF 335
Cdd:cd15135   319 VF 320
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
45-335 3.46e-06

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 48.17  E-value: 3.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASrYFF--DEWVFGKLGCKLIPAI 122
Cdd:cd15922     2 AIPVFLSLVFLGGFLLNSFSLWIFWFRIKQWSSGTILQFNLALSDAIITPA-APLLIA-YFSlgSHWPFGQFLCQLKVFL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 123 QLTSVGVSVFTLTALSADRYRAIVnpmdmQTSGVVLW---TSLKAV--GIWVVSVLLAVPEAVFSEVARIGSSdnssfTA 197
Cdd:cd15922    80 LSTHMYGSIYFLMLISIHRYVTVV-----HYNWKSLWkkkSFMKKLclGVWLLLFVQGLPFFFVLKTSVIDGK-----TK 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 198 CIPYPQTD-ELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPgeynehtKKQMETRKRLAKIVLVFVgCFV 276
Cdd:cd15922   150 CLSIHQSElSLLYFVWNFVLLILGFLLPFGVSLTCYALLGASIAKMNSNNA-------RGRAMKAKSLQMIGISLV-IFI 221
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 277 FCWFPNHI---LYLYRSFNYKEIDPSLGHM-IVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15922   222 ICFVPLHVtrtVGVVVKLFYPESCTLLHKVeVAYYISWVLTGVNCCLDPLLYCFASEKFRKSF 284
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
49-335 4.08e-06

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 47.85  E-value: 4.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGC------KLIPAI 122
Cdd:cd15350     6 VFFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKTLENILIILADMGYLNRRGPfetkldDIMDSL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 123 QLTSVGVSVFTLTALSADRYRAIV------NPMDMQTSGVVLWTslkavgIWVVSVLLAVPEAVFSEVARIgssdnssft 196
Cdd:cd15350    86 FCLSLLGSIFSILAIAADRYITIFhalryhNIMTMRRTLVILAI------IWTFCGGSGILMILFFHFVAT--------- 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 197 acipypqtdelhpkihsVLIFLVYFLIPLVIISIYYYH---IAKTLIRSAHNLPGEYNEHTKKQMetrkRLAKIVLVFVG 273
Cdd:cd15350   151 -----------------VICFTVLFFLMLVLILCLYVHmflLARSHARKIASLPNHHAQHQRSNM----RGAITLTILLG 209
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958642650 274 CFVFCWFPN--HILY--LYRSFNYKEIDPSLGHMIVTLVarvlsFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15350   210 VFVCCWAPFvlHLLLmmFCPMNPYCACYRSLFQVNGTLI-----MSHAVIDPAIYAFRSPELRNTF 270
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
45-333 4.65e-06

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 47.95  E-value: 4.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLV-KIFLTNSTMrSVPNIFISNLAAGDLLLLlTCVPVDASRYFF-DEWVFGKLGCKLIPAI 122
Cdd:cd15379     2 LLPLVYSVVFLLGLPLNAVVIgQIWATRQAL-SRTTIYMLNLATADLLYV-CSLPLLIYNYTQkDYWPFGDFTCRLVRFQ 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 123 QLTSVGVSVFTLTALSADRYRAIVNPMDM-QTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVariGSSDNSsfTACIPY 201
Cdd:cd15379    80 FYTNLHGSILFLTCISVQRYLGICHPLASwHKKKGKKLTWLVCGAVWLVVIAQCLPTFVFAST---GTQRNR--TVCYDL 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 202 -PQTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRsahnlPGEYNEHTKKQMETRKRLAKIVLVFVGCFVFCWF 280
Cdd:cd15379   155 sPPARSTAYFPYGITLTRTGFLLPFAARLACYCSMATILCR-----VVIAVAVVAAPGEKRGKAARMIIVVAAVFLISFL 229
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 281 PNHilylYRSFNYKEIDPSLGHMIVTLVA--------RVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15379   230 PFH----YTKTRYLQVRSWDGGPCTTRQAfaeaykrtRPFASMNSVLDPILFYFTQSKFRP 286
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
49-336 5.21e-06

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 47.43  E-value: 5.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPN-IFISNLAAGDLLLLLTcVPVDASRYFFDEWVFGKLGCKLIPAIQLTSV 127
Cdd:cd14983     6 VYVLTILLGLPSNLLALYAFVNRARLRLTPNvIYMINLCLSDLVFILS-LPIKIVEALSSAWTLPAVLCPLYNLAHFSTL 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSV----LLAVPEAVFSEVARIGSSDNSS-----FTAc 198
Cdd:cd14983    85 YASTCFLTAISAGRYLGVAFPIKYQLYKKPLYSCLVCVAIWALVIfhvtLVFILETSGGTLDINTPVGNSStcyenFTP- 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 199 ipyPQTDELHPKIHSvlIFLVYFLIPLVIISIYYYHIAKTLIRSAhnlpgeynEHTKKqmetRKRLAKIVLVFVGCFVFC 278
Cdd:cd14983   164 ---EQLALLAPVRLE--LSLVLFFLPLAITAFCYVRCIRILVRSR--------LHERR----KRRAVRVAVSTLLTFVVC 226
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958642650 279 WFPNHILYLYrSFNYKEiDPSLGHmivtlVARVLSFSNSCVNPFALYLLSESFRKHFN 336
Cdd:cd14983   227 FGPYNISHVV-GFVRHE-SVWWRK-----LALLTSTCNAFLDPLIFYFLSSSMERGFV 277
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
45-333 5.87e-06

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 47.50  E-value: 5.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTnstMRSVPN--IFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAI 122
Cdd:cd15150     2 IFPLLYTVLFIVGLTMNGLAMRVFFQ---IPSKSNfiIFLKNTVISDLLMILTFPFKILSDAKLGSWPLRGFVCQVTSVI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 123 QLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVF-SEVARIGSSDNSSFTacipy 201
Cdd:cd15150    79 FYFTMYISILFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSTVIWASMFALSLPNMILtNRQPTPKNVKKCSLL----- 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 202 pqTDELHPKIHSVLIFL--VYFLIPLVIISIYYYHIAKTLIRSahnlpgeYNEHTKKQMETRKRLAKIVLVFVGCFVFCW 279
Cdd:cd15150   154 --KSEFGLVWHEIVNYIcqVIFWVNFLIVIVCYTLITKELYKS-------YKRTRGVGKVSRKKVNVKVFIIIAVFFICF 224
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958642650 280 FPNH---ILY-LYRSFNYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15150   225 VPFHfarIPYtLSQTRDVFDCTAKNTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRN 282
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
61-335 1.09e-05

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 46.56  E-value: 1.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  61 NIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVpvdasRYFFDEWVFGKLGCKLIP-AIQLTSVGVSVFTLTALSA 139
Cdd:cd15961    18 NAIVVLIIFQNPSLRAPMFLLIGSLALADLLAGIGLI-----LNFIFAYLLQSEAAKLVTvGLIVASFSASVCSLLAITV 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 140 DRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARigssDNSSFTACIPYPQTDelhpkihsVLIFLV 219
Cdd:cd15961    93 DRYLSLYYALTYNSERTVTFTYVMLVLLWGASICLGLLPVMGWNCLA----DESTCSVVRPLTKNN--------AAILSV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 220 YFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNHILYLYRSFNYkeidPS 299
Cdd:cd15961   161 SFLLMFALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTY----PS 236
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1958642650 300 lghmIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15961   237 ----IYTYATLLPATYNSIINPVIYAFRNQEIQKAL 268
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
51-332 1.14e-05

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 46.37  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  51 LIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVS 130
Cdd:cd15404     8 IFILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFALVTIITTRWIFGDAFCRVSAMFFWLFVMEG 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 131 VFTLTALSADRYRAIVNPMDM---QTSGVVLWTSlkavgiWVVSVLLAVPEAVFSEVARIGSSDnssfTACIPYPQTDEL 207
Cdd:cd15404    88 VAILLIISIDRFLIIVQKQDKlnpYRAKVLIAVS------WAVSFCVAFPLAVGSPDLQIPSRA----PQCVFGYTTNPG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 208 HpKIHSVLIFLVYFLIPLVIISIYYYHIAKTlIRSahnlpgeynehtkkqmeTRKRLAKIVLVFVGCFVFCWFPNHILYL 287
Cdd:cd15404   158 Y-QAYVILIMLIFFFIPFMVMLYSFMGILNT-VRS-----------------FKTRAFTTILILFIVFTVCWAPFTTYSL 218
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1958642650 288 YRSFNYKEIDPSLGHMIVTLVARvLSFSNSCVNPFALYLLSESFR 332
Cdd:cd15404   219 VATFNSHFYHKHNFFEISTWLLW-LCYLKSALNPLIYYWRIKKFR 262
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
52-342 1.16e-05

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 46.78  E-value: 1.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIP-AIQLTSVgVS 130
Cdd:cd15084    19 MVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTMCEFEGfMVSLTGI-VG 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 131 VFTLTALSADRYRAIVNPM---DMQTSGVVLWTSLKAVG--IWVVSVLLA----VPEAVfsevarigssdnssFTACIPY 201
Cdd:cd15084    98 LWSLAILAFERYLVICKPMgdfRFQQRHAVSGCAFTWGWslLWTSPPLFGwssyVPEGL--------------RTSCGPN 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 202 PQTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNlpgEYNEHTKKQMEtrKRLAKIVLVFVGCFVFCWFP 281
Cdd:cd15084   164 WYTGGTNNNSYILALFVTCFALPLSTIIFSYSNLLLTLRAVAAQ---QKESETTQRAE--KEVTRMVIAMVMAFLICWLP 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958642650 282 NHILYLYRSFNYK-EIDPSLGHMivtlvARVLSFSNSCVNPFALYLLSESFRKHFNSQLCCG 342
Cdd:cd15084   239 YATFAMVVATNKDvVIQPTLASL-----PSYFSKTATVYNPIIYVFMNKQFRSCLLELLCCG 295
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
45-333 1.54e-05

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 46.31  E-value: 1.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFL---TNSTMRsvpnIFISNLAAGDLLLLLTcVPVDA-SRYFFDEWVFGKLGCKLIP 120
Cdd:cd15151     2 VFPVLYTVLFLVGLILNSVAAWIFFhipSTSTFI----VYLKNTLVADLIMTLM-LPFKIlSDSGLGPWQLRAFVCRFSA 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 121 AIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVAriGSSDNSSFTACIP 200
Cdd:cd15151    77 VVFYITMYISIILLGLISFDRYLKIVRPFGKSWVQRVRFAKILSGAVWLVMFLLSVPNMILSNKP--ATPISVKKCASLK 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 201 YPqtdeLHPKIHSVLIFL--VYFLIPLVIISIYYYHIAKTLIRSahnlpgeYNEHTKKQMETRKRLAKIVLVFVGCFVFC 278
Cdd:cd15151   155 SP----LGLKWHEVVNYIcqFIFWGVFALMVLFYTIISKKVYES-------YKKSRSKDNKASKKTKAKVFIIVAVFFVC 223
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 279 WFPNH---ILYLYrSFNYKEIDPSLGHMIVTL--VARVLSFSNSCVNPFALYLLSESFRK 333
Cdd:cd15151   224 FAPFHfvrVPYTL-SQTGKITDCQLQNLLYIAkeITLWLAATNVCLDPLIYIFLCKSFRQ 282
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
49-332 2.05e-05

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 45.91  E-value: 2.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVD-ASRYFFDEWVFGKLGCKLIPAIQLTSV 127
Cdd:cd15167     6 FYYLIFLIGFIGSCFALWAFIQKRSSRKCINIYLINLLTADFLLTLA-LPVKiAVDLGIAPWKLKIFHCQVTACLIYINM 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSevarIGSSDNSSFTACIPYPQTDEL 207
Cdd:cd15167    85 YLSIIFLGFVSIDRYLQLTHSSKLYRIQEPGFAKMISAVVWTLVLFIMVPNMAIP----IKTIEEKPGVGCADFKTEFGR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 208 HPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRsahnlpgeyNEHTKKQMETRKRLAKIVLVFVGcFVFCWFPNHILYL 287
Cdd:cd15167   161 HWHVLTNFICMAIFLNFSAIILISNFLVIRKLYR---------NKDSEEYRNARQALVNILLVTAG-YVICFVPYHIVRI 230
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1958642650 288 YRSFNYKEIDPSLGHMIVTLVAR----VLSFSNSCVNPFALYLLSESFR 332
Cdd:cd15167   231 PYTLSQSEVITDCSLKRSLFLAKestlLLAVLNLCFDPILYFHLSKAFR 279
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
56-335 2.26e-05

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 45.62  E-value: 2.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  56 VGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDL-----LLLLTCVPVDASRYFFD---EWVFGKlGCKLIPAIQLTSV 127
Cdd:cd15360    13 LAITGNIVVLAILLTSQYKLTVPRFLMCNLAFADLcmgiyLLLIASVDIRTKSQYYNyaiDWQTGA-GCAAAGFFTVFAS 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVpeavfseVARIGSSDNSSFTACIPypqTDEL 207
Cdd:cd15360    92 ELSVYTLTVITLERWHTITYAMQLDRKVRLRHAAVIMVGGWIFAFTVAL-------LPIFGISSYMKVSICLP---MDIE 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 208 HPKIHSVLIF-LVYFLIPLVIISIYYYHIAKTlIRSAHNLPGEYNEHTKKQMEtrkrlakiVLVFVGcfVFCWFPNHILY 286
Cdd:cd15360   162 SPLSQAYIIFiLVLNVLAFLIICACYIKIYLT-VRNPNFVSSNSDTKIAKRMA--------VLIFTD--FLCMAPISFFA 230
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1958642650 287 LYRSFNYKEIDPSLGHMIVTLVARVlsfsNSCVNPFALYLLSESFRKHF 335
Cdd:cd15360   231 ISASLKVPLITVSKSKILLVLFYPI----NSCANPFLYAIFTKTFRRDF 275
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
48-177 4.25e-05

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 44.54  E-value: 4.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  48 SLYLIIISVGL-LGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTS 126
Cdd:cd15214     3 SIAIIIIAILIcLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLI 82
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 127 VGVSVFTLTALSADRYRAIVNPM--DMQTSGVVLWTSLkaVGIWVVSVLLAVP 177
Cdd:cd15214    83 SSASMLTLGAIAIDRYYAVLYPMvyPMKITGNRAVLAL--VYIWLHSLIGCLP 133
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
49-240 7.07e-05

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 44.01  E-value: 7.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCkLIPAIQLTSVG 128
Cdd:cd15428     6 LFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRC-AAQLYFFLSFG 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VS-VFTLTALSADRYRAIVNPM---DMQTSGVVLWTslkAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTACIP---- 200
Cdd:cd15428    85 ITeCALLSVMSYDRYVAICLPLrysLIMTWKVCISL---ATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMpall 161
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1958642650 201 -YPQTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLI 240
Cdd:cd15428   162 kLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVF 202
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
52-242 7.17e-05

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 44.02  E-value: 7.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSV 131
Cdd:cd15054     9 LIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCCSASI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 132 FTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVP--EAVFSEVARIGSSDNSSFtacIPYPQTDELHP 209
Cdd:cd15054    89 LNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLpiELGWHELGHERTLPNLTS---GTVEGQCRLLV 165
                         170       180       190
                  ....*....|....*....|....*....|....
gi 1958642650 210 KIHSVLI-FLVYFLIPLVIISIYYYHIAKTLIRS 242
Cdd:cd15054   166 SLPYALVaSCLTFFLPSGAICFTYCRILLAARKA 199
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
56-335 7.75e-05

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 44.08  E-value: 7.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  56 VGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDL---LLLLTCVPVDA---SRYFFD--EWVFGKlGCKLIPAIQLTSV 127
Cdd:cd15359    13 LAIAGNLIVLFVLLTSRYKLTVPRFLMCNLSFADFcmgLYLLLIASVDSqtkSQYYNHaiDWQTGS-GCSTAGFFTVFAS 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVpeavfseVARIGSSDNSSFTACIPYPQTDEL 207
Cdd:cd15359    92 ELSVYTLTVITLERWHTITYAMQLDRKLRLRHAILIMLGGWVFSLLIAV-------LPLVGVSNYMKVSICLPMDIETLL 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 208 HPKIhsVLIFLVYFLIPLVIISIYYYHIAktlirsahnLPGEYNEHTKKQMETRkrLAKIVLVFVGCFVFCWFPNHILYL 287
Cdd:cd15359   165 SQAY--ILLILVLNVIAFLVICACYIKIY---------LAVQNPELVAKNKDTK--IAKRMAILIFTDFTCMAPISFFAI 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1958642650 288 YRSFNYKEIDPSLGHMIVTLVARVlsfsNSCVNPFALYLLSESFRKHF 335
Cdd:cd15359   232 SAAFKVPLITVTNSKILLVLFYPI----NSCANPFLYAIFTKAFRRDF 275
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
61-296 9.38e-05

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 43.77  E-value: 9.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  61 NIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVpvdasRYFFDEWVFGKLGCKLIP-AIQLTSVGVSVFTLTALSA 139
Cdd:cd15962    18 NAIVVAIIFYTPTLRTPMFVLIGSLATADLLAGCGLI-----LNFVFQYVIQSETISLITvGFLVASFTASVSSLLAITV 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 140 DRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVpeavfseVARIGSSDNSSFTAC-IPYPQTdelhpKIHSVLIFL 218
Cdd:cd15962    93 DRYLSLYNALTYYSEKTVLGVHLMLAATWGVSLCLGL-------LPVLGWNCLEERASCsIVRPLT-----KSNVTLLSA 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958642650 219 VYFLIPLVIISIyYYHIAKTLIRSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNHILYLYRSFNYKEI 296
Cdd:cd15962   161 SFFFIFILMLHL-YIKICKIVCRHAHQIALQQHFLTASHYVATKKGVSTLAIILGTFGASWLPFAIYCVVGDHEYPAV 237
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
125-335 9.58e-05

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 43.63  E-value: 9.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNPM---DMQTSGVVLWTslkaVGIWVVSVLLA-VPEAVFSEVARIgssDNSSFTAciP 200
Cdd:cd15342    81 TSLTASVANLLAIAVERHQTIFTMQlhsKMSNQRVVILI----FGIWMVALILGlIPAMGWNCLCDL---KRCSTMA--P 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 201 YPQTDELhpkIHSVLIFLVYFLIPLVIisiyYYHIAKTLIRSAHNLPGEYNEHTKKQmETRKRLAKIVLVFVGCFVFCWF 280
Cdd:cd15342   152 LYSRSYL---VFWALSNLLTFLIMVAV----YTRIFIYVRRKSQRMSEHHSSHPRYR-ETVLGLMKTVVIILGAFVVCWT 223
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958642650 281 PNHILYLYRSFNYKEIDPSLGHMIVTLVARvlsfSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15342   224 PGQVVLLLDGLGCESCNVLAYEKYFLLLAE----INSLVNPIVYSYRDKEMRKTF 274
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
58-321 1.27e-04

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 43.23  E-value: 1.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  58 LLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFfdEWVFGKLGCKLIPAIQLTSVGVSVFTLTAL 137
Cdd:cd15070    15 VVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVVSL--GVTIHFYSCLFMSCLLVVFTHASIMSLLAI 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 138 SADRYRAIVNPMDMQ--TSGVVLWTslkAVGI-WVVSVLLAVPEAVFSEVARIGSSDNSSFTACipypQTDELHPKIHSV 214
Cdd:cd15070    93 AVDRYLRVKLTVRYRivTTQRRIWL---ALGLcWLVSFLVGLTPMFGWNRKPSLESVNTTPLQC----QFTSVMRMDYMV 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 215 LI-FLVYFLIPLVIISIYYYHIAKtLIRSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNHILYLYRSFNY 293
Cdd:cd15070   166 YFsFFTWILIPLVIMCALYVDIFY-IIRNKLSQNATGFRETGAFYGREFKTAKSLALVLFLFAVCWLPLSIINCVVYFNP 244
                         250       260
                  ....*....|....*....|....*...
gi 1958642650 294 KEIDPSLghmivtLVARVLSFSNSCVNP 321
Cdd:cd15070   245 KVPKIAL------YLGILLSHANSMMNP 266
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
52-332 1.46e-04

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 43.28  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  52 IIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSV 131
Cdd:cd15080     9 LLILLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVFGPTGCNLEGFFATLGGEIAL 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 132 FTLTALSADRYRAIVNPMdmqtSGVVLWTSLKAVGI---WVVSVLLAVPeAVFSEVARIGSSDNSSftaCIP--YPQTDE 206
Cdd:cd15080    89 WSLVVLAIERYVVVCKPM----SNFRFGENHAIMGVaftWVMALACAAP-PLVGWSRYIPEGMQCS---CGIdyYTLKPE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 207 LHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAhnlpGEYNEHTKKQmETRKRLAKIVLVFVGCFVFCWFPNHILY 286
Cdd:cd15080   161 VNNESFVIYMFVVHFTIPLIVIFFCYGRLVCTVKEAA----AQQQESATTQ-KAEKEVTRMVIIMVIAFLICWVPYASVA 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1958642650 287 LYrSFNYKEIDpsLGHMIVTLVArVLSFSNSCVNPFALYLLSESFR 332
Cdd:cd15080   236 FY-IFTHQGSD--FGPIFMTIPA-FFAKSSAVYNPVIYILMNKQFR 277
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
50-287 1.55e-04

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 43.09  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  50 YLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVP--VDASRYffdEWVFGKLGCKLIPAIQLTSV 127
Cdd:cd15165     7 YIPTFVLGLLLNLMALWVFLFKIKKWTESTIYMINLALNDLLLLLS-LPfkMHSSKK---QWPLGRTLCSFLESLYFVNM 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNPMdmqtSGVVLWTSLKAVG----IWVVSVLLAVPEAVFSEvarigssDNSSFTACIpYPQ 203
Cdd:cd15165    83 YGSILIIVCISVDRYIAIRHPF----LAKRLRSPRKAAIvcltIWVFVWAGSIPIYSFHD-------KPTNNTRCF-HGF 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 TDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAhnlpGEYNEHTKKqmetrKRLAKIVLVFVGCFVFCWFPNH 283
Cdd:cd15165   151 SNKTWSKKVIVVVEEFGFLIPMAVMVFCSVQIIRTLLDMR----RPEQPKVKQ-----NKSVKIVLSNLVVFLVCFTPYH 221

                  ....
gi 1958642650 284 ILYL 287
Cdd:cd15165   222 LGIF 225
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
116-328 1.73e-04

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 42.89  E-value: 1.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 116 CKLIPAIQLTSVGVSVFTLTALSADRYRAIVNPMDM-----QTSGVVLWTSlkavgiWVVSVLLAVPEA-VFSEVARIGS 189
Cdd:cd15385    73 CRIVKHLQVLGMFASTYMLVMMTADRYIAICHPLKTlqqptKRSYLMIGSA------WALSFILSTPQYfIFSLSEIENG 146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 190 SDNSSFTACIPYPQTdelhPKIHSVLIFLVYFLIPLVIISIYY----YHIAKTL---------IRSAHNLPGEYNEHTKK 256
Cdd:cd15385   147 SGVYDCWANFIVPWG----IKAYITWITISIFVVPVIILLTCYgficYNIWRNIkcktrrglsDNALKNILLAVCVSSVK 222
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958642650 257 QMETRK-RLAKIVLVFVGCFVFCWFPNHILYLYRSFNYKEIDPSLGHMIVTLVARVLSFsNSCVNPFALYLLS 328
Cdd:cd15385   223 TISRAKiRTVKMTFVIVLAYIVCWAPFFTIQMWSVWDQNFPWDESENTAVTITALLASL-NSCCNPWIYMFFS 294
7tmA_GPR139 cd15919
G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G ...
50-332 2.73e-04

G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR139, a vertebrate orphan receptor, is very closely related to GPR142, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320585 [Multi-domain]  Cd Length: 270  Bit Score: 42.19  E-value: 2.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  50 YLIIISVGLLGNIMLVKIF--LTNSTMRSVPNIFISnLAAGDLLLLLTCVPVDasrYFFDEWVFGK----LGCKLIPAIQ 123
Cdd:cd15919     7 YSLLLCLGLPANILTVIILsqLVARRQKSSYNYLLA-LAAADILVLFFIVFVD---FLLEDFILNKqmpqVLDKIIEVLE 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEvarIGSSDNSSFTAcipypq 203
Cdd:cd15919    83 FSSIHTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTSIPYYWWPN---IWIEDYTSTSM------ 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 204 tdelhpkiHSVLIFLVYFLIPLVIISIYYyhIAKTLIrsAHNLPGEYNEHTKKqMETRKRLAkIVLVFVGCFVFCWFPNH 283
Cdd:cd15919   154 --------HHVLIWIHCFTVYLVPCSIFF--VLNSII--VYKLRRKSNFRLRG-YSTGKTTA-ILFTITSIFAILWAPRI 219
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1958642650 284 ILYLYRSFNYKEIDPSLGHmIVTLVARVLSFSNSCVNPFALYLLSESFR 332
Cdd:cd15919   220 IMILYHLYVSPINNSWLVH-IVSDIANMLALLNTAINFFLYCFISKRFR 267
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
45-281 3.73e-04

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 42.09  E-value: 3.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLT----CVPVDASRYFFdewvFGKLGCKLiP 120
Cdd:cd15082    15 VLAALMFVVTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTggtiSFLTNARGYFF----LGVWACVL-E 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 121 AIQLTSVG-VSVFTLTALSADRYRAIVNPMdmqtSGVVLWTSLKAVGI---WVVSVLLAVPEAV---FSEVARIGssdns 193
Cdd:cd15082    90 GFAVTFFGiVALWSLAVLAFERFFVICRPL----GNIRLQGKHAALGLlfvWTFSFIWTIPPVLgwsSYTVSKIG----- 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 194 sfTACIPYPQTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLiRSAHNLPGEYNEHTKKQmetrKRLAKIVLVFVG 273
Cdd:cd15082   161 --TTCEPNWYSGNMHDHTYIITFFTTCFILPLGVIFVSYGKLLQKL-RKVSNTQGRLGNARKPE----RQVTRMVVVMIV 233

                  ....*...
gi 1958642650 274 CFVFCWFP 281
Cdd:cd15082   234 AFMVCWTP 241
7tmA_RXFP2_LGR8 cd15966
relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G ...
114-333 3.85e-04

relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural similarity, but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. INSL3 is the endogenous ligand for RXFP2, which couples to the G(s) protein to increase intracellular cAMP levels, but also to the GoB protein to decrease cAMP formation. RXFP2 (or LGR8) is expressed in various tissues including the brain, kidney, muscle, testis, thyroid, uterus, and peripheral blood cells, among others.


Pssm-ID: 320632  Cd Length: 287  Bit Score: 42.08  E-value: 3.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 114 LGCKLIPAIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVlWTSLKAVGIWVVSVLLAV----PEAVFSEV-ARIG 188
Cdd:cd15966    78 LQCRIIGFLAMLSTEVSVLLLTYLTLEKYLVIVFPFSNIRPGKC-QTLIILISIWLVGFIIAVipfwNEDFFGNYyGKNG 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 189 ssdnssftACIP--YPQTDELHPKIHSVLIFLVYFLIPLVIISIYY----YHIAKTLIRSAhnlpgEYNEHTKKQMETRK 262
Cdd:cd15966   157 --------VCFPlhSDQTEKIGAKGYSTGIFLGLNLLAFIIIVFSYssmfCSIQKTGLQTT-----EVRSHIHRDVAVAN 223
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 263 RLAKIVLvfvgCFVFCWFPNHILYLYRSFNYkEIDPSLGHMIVTLVARVlsfsNSCVNPFaLYLLSESFRK 333
Cdd:cd15966   224 RFFFIVF----SDAICWIPIFLLKILSLFQV-EIPGTITSWIVIFILPI----NSALNPI-LYTLTTSFFK 284
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
49-335 4.34e-04

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 41.70  E-value: 4.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNStMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVG 128
Cdd:cd15333    11 LALITLATTLSNAFVIATIYLTRK-LHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLSSDITCCT 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 129 VSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVarigsSDNSSFTACIpyPQTDELH 208
Cdd:cd15333    90 ASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFFWRQA-----KAEEEVSECV--VNTDHIL 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 209 PKIHSVlifLVYFLIPLVIISIYYYHIaktlirsahnlpgeYNEHTKKQMETRKRLAKIvlvfVGCFVFCWFPNHILYLY 288
Cdd:cd15333   163 YTVYST---VGAFYIPTLLLIALYGRI--------------YVEARARERKATKTLGII----LGAFIVCWLPFFIISLV 221
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1958642650 289 RSFNYkeiDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15333   222 LPICK---DACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAF 265
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
61-321 6.90e-04

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 41.04  E-value: 6.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  61 NIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEwvfgKLGCKLIPAIQLTSVGVSVFTLTALSAD 140
Cdd:cd15960    18 NAIVIAILFYTPSLRAPMFILIGSLALADLLAGLGLIANFVAIYVMNS----EAVTLCSAGLLLAAFSASVCSLLAITVD 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 141 RYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARigssDNSSFTACIPYPQtdelhpkiHSVLIFLVY 220
Cdd:cd15960    94 RYLSLYNALTYHTERTLTFTYGLLALLWLTCIGIGLLPAMGWNCLR----APASCSVLRPVTK--------NNAAVLAVS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 221 FLIPLVIISIYYYHIAKTLIRSAHNLPGEYN-EHTKKQMETRKRLAKIVLVfVGCFVFCWFPNHILYLYRSFNYKeidps 299
Cdd:cd15960   162 FLLLFALMMQLYLQICRIAFRHAQQIAVQHQfVNFCLASSTRKGVSTLSLI-LATFAFCWVPFAVYSMVADSSYP----- 235
                         250       260
                  ....*....|....*....|..
gi 1958642650 300 lghMIVTLVARVLSFSNSCVNP 321
Cdd:cd15960   236 ---MIYTYYLVLPAACNSVINP 254
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
45-338 7.33e-04

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 41.09  E-value: 7.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLvkIFLTNSTMRSVP-NIFISNLAAGDLLLLLtCVPVDASRYFFDEWVFGKLGCKLIPAIQ 123
Cdd:cd14973     2 VIFSLTVLLSLCGLVGNGLV--LWLLGFRIKRNPfSVYILNLAAADFLFLS-CQAIQSLEDLLGGSLPGFALCRLLATLM 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPM------DMQTSGVVlwtslkAVGIWVVSVLLAVPEAVFSEVARIGssdnSSFTA 197
Cdd:cd14973    79 FFSYTVGLSLLAAISTERCLSVLFPIwyrchrPKHLSAVV------CALLWALSLLLSVLESYFCGFLFWK----FNESA 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 198 CipypqtdeLHPKIHSVLIFLVYFLIpLVIISiyyyhiAKTLIR---SAHNLPgeynehtkkqmetRKRLAKIVLVFVGC 274
Cdd:cd14973   149 C--------RTFNFLSALLFLLLFLV-MCVSS------LTLLIRvqcSSQRRP-------------PTRLYVVILLTVLV 200
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958642650 275 FVFCWFP---NHILYLYRSFNYkeidPSLGHMIVTLvarvLSFSNSCVNPFaLYLLSESFRKHFNSQ 338
Cdd:cd14973   201 FLLCGLPlgiYWFLLLWFSNYL----FHTFHPISDL----LSCVNSSANPI-IYFFVGSLRGRRLRE 258
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
45-335 7.67e-04

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 41.05  E-value: 7.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNI-FISNLAAGDLLLLLTCVpvdasRYFFDEWVFGKLGCKLIPAIQ 123
Cdd:cd15340     2 AIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYhFIGSLAVADLLGSVIFV-----YSFLDFHVFHRKDSPNVFLFK 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 L----TSVGVSVFTLTALSADRYRAIVNPMDMQTsgvvLWTSLKAV----GIWVVSVLLAVPEAVFSEVARIGSSDNSSF 195
Cdd:cd15340    77 LggvtASFTASVGSLFLTAIDRYISIHRPLAYKR----IVTRTKAViafcVMWTIAIVIAVLPLLGWNCKKLNSVCSDIF 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 196 tacipyPQTDELHpkihsvLIFLVYFLIPLVIISIYYY---------HIAKTLIRSAHNLPGEYNEHTKKQMETRK---- 262
Cdd:cd15340   153 ------PLIDETY------LMFWIGVTSVLLLFIVYAYmyilwkahhHAVRMLQRGTQKSIIVYTSEDGKVQTTRPdqtr 220
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958642650 263 ---RLAKIVLVFVGCFVFCWFPNHILYLYRSFNykeidpSLGHMIVTLVA--RVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15340   221 mdiRLAKTLVLILVVLIICWGPLLAIMVYDVFG------KMNKLIKTVFAfcSMLCLLNSTVNPIIYALRSKDLRHAF 292
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
45-335 8.03e-04

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 40.71  E-value: 8.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPN-IFISNLAAGDLLLLLTcVP---VDASRYFfdEWVFGKLGCKLIP 120
Cdd:cd15170     2 LVLAVYIITFLIGLPANLLAFYTFIRKVRRKPTPIdILLLNLTVSDLIFLLF-LPfkmAEAASGM--IWPLPYFLCPLSS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 121 AIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAvpEAVFSEVARIGSSDNSSFTACIP 200
Cdd:cd15170    79 FIFFSTIYISTLFLTAISVERYLGVAFPIKYKLRRRPLYAVIASVFFWVLAFSHC--SIVYIVEYHIDSENTSVTNNSRC 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 201 YPQ-TDElhpKIHSVL-----IFLVYFLIPLVIISIYYYHiaktLIRSAHNLPgeyneHTKKQmeTRKRLAKIVLVFVGC 274
Cdd:cd15170   157 YDNfTPE---QLKILLpvrleLFLVLFCIPFLITCFCYIN----FIRILSSLP-----HISRQ--RKQRAIGLAVATLLN 222
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958642650 275 FVFCWFPNHILYLyrsFNYKEIDPSLGHMIVTLvarvLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15170   223 FIVCFAPYNISHV---VGFIQRKSPEWRMYALL----LSTLNACLDPIIFYFSSSAVRRAF 276
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
49-335 8.57e-04

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 40.92  E-value: 8.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  49 LYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLlllltcvpVDASRYFFDEWVFGKLGCKLIPAI------ 122
Cdd:cd15102     6 VFVAICCFIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDL--------LAGAAYLANILLSGARTLRLSPAQwflreg 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 123 -QLTSVGVSVFTLTALSADRYRAIVN--PMDMQTSGVVLwtsLKAVGIWVVSVLLAVPEAvfsevarIGSSDNSSFTAC- 198
Cdd:cd15102    78 sMFVALSASVFSLLAIAIERHLTMAKmkPYGASKTSRVL---LLIGACWLISLLLGGLPI-------LGWNCLGALDACs 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 199 --IPypqtdeLHPKiHSVLIFLVYFLIPLVIISIYYYHIAkTLIRSAHNlpgeyNEHTKKQMETRKRLAKIVLVFVGCFV 276
Cdd:cd15102   148 tvLP------LYSK-HYVLFCVTIFAGILAAIVALYARIY-CLVRASGR-----KATRASASPRSLALLKTVLIVLLVFI 214
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958642650 277 FCWFPNHILYLYRSFNYKEIDPSLGHMIVTLVARVLsfsNSCVNPFALYLLSESFRKHF 335
Cdd:cd15102   215 ACWGPLFILLLLDVACPVKTCPILYKADWFLALAVL---NSALNPIIYTLRSRELRRAV 270
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
48-241 9.34e-04

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 40.61  E-value: 9.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  48 SLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCklipAIQ---- 123
Cdd:cd15421     5 SLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGC----GTQifff 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 LTSVGVSVFTLTALSADRYRAIVNPM--DMQTSGVVLWtsLKAVGIWVVSVLLAVPEAVfsevarigssdnssFTACIPY 201
Cdd:cd15421    81 LTLGGAECLLLALMAYDRYVAICHPLryPVLMSPRVCL--LMAAGSWLGGSLNSLIHTV--------------YTMHFPY 144
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958642650 202 PQTDELHpkiH----------------SVLIFLVYF------LIPLVIISIYYYHIAKTLIR 241
Cdd:cd15421   145 CGSREIH---HffcevpallklscadtSAYETVVYVsgvlflLIPFSLILASYALILLTVLR 203
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
48-243 1.02e-03

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 40.46  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  48 SLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSV 127
Cdd:cd15429     5 VLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALG 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 128 GVSVFTLTALSADRYRAIVNP---MDMQTSGVVLWTslkAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSFTAC-----I 199
Cdd:cd15429    85 GTEFILLAVMAYDRYVAVCHPlryTVIMSGGLCIQL---AAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCellavV 161
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1958642650 200 PYPQTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTL--IRSA 243
Cdd:cd15429   162 RLACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAIlrIRSS 207
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
61-321 1.19e-03

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 40.15  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  61 NIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEwvfgklgckliPAIQLTSVGV-------SVFT 133
Cdd:cd15100    18 NAIVVAIIFSTPSLRAPMFLLIGSLALADLLAGLGLILHFVFRYCVYS-----------EALSLVSVGLlvaafsaSVCS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 134 LTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSsdnssfTACIPYPQTdelhpKIHS 213
Cdd:cd15100    87 LLAITVDRYLSLYNALTYYSERTLTFTYVMLALLWTLALGLGLLPVLGWNCLREGS------SCSVVRPLT-----KNHL 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 214 VLIfLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNE-HTKKQMETRKRLAKIVLVfVGCFVFCWFPNHILYLYRSFN 292
Cdd:cd15100   156 AVL-AVAFLLVFALMLQLYAQICRIVLRHAHQIALQRHFlAPSHYVATRKGVSTLALI-LGTFAACWIPFAVYCLLGDGS 233
                         250       260
                  ....*....|....*....|....*....
gi 1958642650 293 YKeidpslghMIVTLVARVLSFSNSCVNP 321
Cdd:cd15100   234 SP--------ALYTYATLLPATYNSMINP 254
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
45-335 1.65e-03

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 39.92  E-value: 1.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLT------CVPVDASRYFFDEWVFGKLGCKL 118
Cdd:cd15354     2 IAAEVFLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSnawetiTIYLLNNRHLVIEDAFVRHIDNV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 119 IPAIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVArigssdnssftac 198
Cdd:cd15354    82 FDSLICISVVASMCSLLAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIWTFCTGCGIIFILYSEST------------- 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 199 ipypqtdelhPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNLPGEYNEHTKKQMETrkrlAKIVLVFVGCFVFC 278
Cdd:cd15354   149 ----------YVIICLITMFFAMLFLMVSLYIHMFLLARTHVKRIAALPGYNSVRQRTSMKG----AVTLTILLGIFIVC 214
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958642650 279 WFPN--HILYLYRSFNYKEIDPSLGHMIVTLvarVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd15354   215 WAPFflHLILMISCPQNLYCVCFMSHFNMYL---ILIMCNSVIDPLIYAFRSQEMRKTF 270
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
116-327 3.00e-03

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 39.03  E-value: 3.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 116 CKLIPAIQLTSVGVSVFTLTALSADRYRAIVNPMdmqTSGVVLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSSDNSSF 195
Cdd:cd15387    73 CRLVKYLQVVGMFASTYMLLLMSIDRCLAICQPL---RSLHRRSDRVYVLFSWLLSLVFSIPQVHIFSLREVGNGVYDCW 149
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 196 TACI-PYpqtdelHPKIHSVLIFLVYFLIPLVIISIYY----YHIAKTL-IRSAHNLPGEYNEHTKKQM----------- 258
Cdd:cd15387   150 ADFIqPW------GPKAYITWITLSVYIIPVLILSVCYglisFKIWQNVkLKTRRETKTPLSSAASGGAalarvssvkli 223
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 259 -ETRKRLAKIVLVFVGCFVFCWFPNHILYLYRSFNYKEIDPSLGHMIVTLVARVlsfsNSCVNPFaLYLL 327
Cdd:cd15387   224 sKAKIRTVKMTFVIVLAYIVCWTPFFFVQMWSVWDPNAPKEASPFIIAMLLASL----NSCCNPW-IYMF 288
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
45-149 3.25e-03

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 38.89  E-value: 3.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCklipAIQL 124
Cdd:cd15416     2 ILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGC----AAQL 77
                          90       100
                  ....*....|....*....|....*....
gi 1958642650 125 TSV----GVSVFTLTALSADRYRAIVNPM 149
Cdd:cd15416    78 CSAatfgTVECFLLAAMAYDRYVAICNPL 106
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
45-335 3.26e-03

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 39.01  E-value: 3.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650  45 VIPSLYLIIISVGLLGNIMLVKIFLTNSTMRSVPNIFISNLAAGDLLLLLTcVPVDASRYFFDE-WVFGKLGCKLipAIQ 123
Cdd:cd14996     2 ALPIIYSFLFVTGVFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLVCSA-MPFQAAYFLKGFyWKYQSTQCRI--ANF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 124 L------TSVGVSVFTLTALSADRYRAIVNPMDMQTS-----GVVLWTSLK-----------AVGIWVVSVLLAVPEAVF 181
Cdd:cd14996    79 FgtlvihVSMCVSILILSWIAISRYATLMKHDSATQKqscyeKIFYGHFLKrfrqpkfarylCIYIWGVVLCIIIPVVVY 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 182 SEVARIGSSDNSsftacIPYPQTDELHPKiHSVLIFLV----YFLIPLVIISIYYYHIaKTLIRSAHNlpgeyNEHTKKQ 257
Cdd:cd14996   159 YSVREADEDGES-----LCYNRQVELGAK-GSQIAGLIattfFFLFFLVVLLSYYSFV-NHLRRIQKN-----TCISEKD 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 258 METRKRLAKIVLVFVgCFVFCWFPNHI--LYLYRSFNYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHF 335
Cdd:cd14996   227 LIYRSVKRNILIIQA-LLVVCFLPYHIfkPVFYVLHQREDCQQLNYLIETKNILTCLASARSSTDPIMYLLLDKTFKKTL 305
7tmA_LPAR3_Edg7 cd15343
lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial ...
125-321 3.38e-03

lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320465 [Multi-domain]  Cd Length: 274  Bit Score: 39.09  E-value: 3.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 125 TSVGVSVFTLTALSADRYRAIVNpMDMQTSGVVLWTSLKAVGIWVVSVLL-AVPEavfsevarIGSSDNSSFTACIPY-P 202
Cdd:cd15343    81 TSLSASLTNLLVIAVERHISIMR-MKVHSNLTKRRVTLLIALVWAIAIFMgAVPT--------LGWNCICNISACSSLaP 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958642650 203 QTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIRSAHNlPGEYNehtkkQMETRKRLAKIVLVFVGCFVFCWFPN 282
Cdd:cd15343   152 IYSRSYLVFWSVSNLVVFLIMVVVYLRIYVYVQRKTNVLSPHT-SGSIN-----RRRTPIKLMKTVMTVLGAFVICWTPG 225
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1958642650 283 HILYLYRSFNYKEIdpslGHMIVTLVARVLSFSNSCVNP 321
Cdd:cd15343   226 LVVLLLDGLNCTRC----GVQHVKRWFLLLALLNSVMNP 260
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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