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Conserved domains on  [gi|1958810387|ref|XP_038956601|]
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lysine-specific demethylase 6A isoform X4 [Rattus norvegicus]

Protein Classification

KDM6 family histone demethylase( domain architecture ID 18639591)

KDM6 family histone demethylase, similar to lysine-specific demethylase 6A (KDM6A), also called UTX (ubiquitously-transcribed TPR protein on the X chromosome) that specifically demethylates 'Lys-27' of histone H3, and UTY (ubiquitously-transcribed TPR protein on the Y chromosome) that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3

CATH:  1.25.40.10|2.60.120.10
EC:  1.14.11.-
Gene Ontology:  GO:0005515|GO:0032452|GO:0031490|GO:0046872
PubMed:  26059336|21153002|10517866|30708253|22404999|11165500|14697267|19478949
SCOP:  4001344|3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
 965-1073 2.76e-33

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation.


:

Pssm-ID: 396791  Cd Length: 114  Bit Score: 124.33  E-value: 2.76e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  965 QLCMKVPGSRIPGHQENNNFCSVNINIGPGDCEWFVVPEDYWGVLNDFCEKNN-------LNFLMSSWWPnlEDLYEANV 1037
Cdd:pfam02373    1 WLYLGMPFSTTPWHIEDQGLYSINYLHFGAPKVWYIIPPEYAEKFEKVLSDHFggeqpddLLHLNTIISP--KQLRENGI 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1958810387 1038 PVYRFIQRPGDLVWINAGTVHWVQAIGWCNNITWNV 1073
Cdd:pfam02373   79 PVYRFVQKPGEFVFTFPGWYHQVFNLGFNIAEAVNF 114
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
282-391 1.89e-20

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 91.99  E-value: 1.89e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  282 AIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 361
Cdd:COG0457     27 AIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELD 106

                           90       100       110
                   ....*....|....*....|....*....|
gi 1958810387  362 HGHAAAWMDLGILYESCNQTQDAIKCYLNA 391
Cdd:COG0457    107 PDDAEALYNLGLALLELGRYDEAIEAYERA 136
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 121-456 8.71e-16

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 79.00  E-value: 8.71e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  121 AAFLYG---LGLVYFYYNAFQWAIRAFQEVLYVDPNfcrAKEIHLRLGFMFKVNTDYESSLKHFQLALRDSNvctlSSVE 197
Cdd:COG2956      5 VAAALGwyfKGLNYLLNGQPDKAIDLLEEALELDPE---TVEAHLALGNLYRRRGEYDRAIRIHQKLLERDP----DRAE 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  198 IQFHIAHLFeIQNGMArnswcskdicfmvirkhrDRgntilqkqpmnnfyklkafhhkskqlycnswmhhnmdlvgdntt 277
Cdd:COG2956     78 ALLELAQDY-LKAGLL------------------DR-------------------------------------------- 94

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  278 keryAIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICA 357
Cdd:COG2956     95 ----AEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKA 170

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  358 VQLDHGHAAAWMDLGILYESCNQTQDAIKCYLNATRSKscSNTSVLISRIKFLQAQLCNLPQ--SSLQNKTKLLPSIEEA 435
Cdd:COG2956    171 LKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQD--PDYLPALPRLAELYEKLGDPEEalELLRKALELDPSDDLL 248

                          330       340
                   ....*....|....*....|.
gi 1958810387  436 WSLpipAELTSRQGAMNTAQQ 456
Cdd:COG2956    249 LAL---ADLLERKEGLEAALA 266
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 48-186 1.30e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 54.35  E-value: 1.30e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387   48 LLNKAIHCYESLIVKAEGKVESdfFCQLGHFNLLLEDYSKALSSYQRYYSLQTDywklwlvcklrfqqkrdtNAAFLYGL 127
Cdd:COG2956     91 LLDRAEELLEKLLELDPDDAEA--LRLLAEIYEQEGDWEKAIEVLERLLKLGPE------------------NAHAYCEL 150

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958810387  128 GLVYFYYNAFQWAIRAFQEVLYVDPNFCRAK----EIHLRLGfmfkvntDYESSLKHFQLALR 186
Cdd:COG2956    151 AELYLEQGDYDEAIEALEKALKLDPDCARALlllaELYLEQG-------DYEEAIAALERALE 206
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
 931-995 7.34e-04

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


:

Pssm-ID: 214721  Cd Length: 58  Bit Score: 38.77  E-value: 7.34e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958810387   931 QLHELTKLPafvrvvSAGNLLSHVGYTILGMNSVQLC-MKVPGSRIPGHQENNNfcSVNINIGPGD 995
Cdd:smart00558    1 QLWNLAKLP------FKLNLLSDLPEDIPGPDVGPYLyMGMAGSTTPWHIDDYD--LVNYLHQGAG 58
 
Name Accession Description Interval E-value
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
 965-1073 2.76e-33

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation.


Pssm-ID: 396791  Cd Length: 114  Bit Score: 124.33  E-value: 2.76e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  965 QLCMKVPGSRIPGHQENNNFCSVNINIGPGDCEWFVVPEDYWGVLNDFCEKNN-------LNFLMSSWWPnlEDLYEANV 1037
Cdd:pfam02373    1 WLYLGMPFSTTPWHIEDQGLYSINYLHFGAPKVWYIIPPEYAEKFEKVLSDHFggeqpddLLHLNTIISP--KQLRENGI 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1958810387 1038 PVYRFIQRPGDLVWINAGTVHWVQAIGWCNNITWNV 1073
Cdd:pfam02373   79 PVYRFVQKPGEFVFTFPGWYHQVFNLGFNIAEAVNF 114
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
282-391 1.89e-20

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 91.99  E-value: 1.89e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  282 AIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 361
Cdd:COG0457     27 AIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELD 106

                           90       100       110
                   ....*....|....*....|....*....|
gi 1958810387  362 HGHAAAWMDLGILYESCNQTQDAIKCYLNA 391
Cdd:COG0457    107 PDDAEALYNLGLALLELGRYDEAIEAYERA 136
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 121-456 8.71e-16

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 79.00  E-value: 8.71e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  121 AAFLYG---LGLVYFYYNAFQWAIRAFQEVLYVDPNfcrAKEIHLRLGFMFKVNTDYESSLKHFQLALRDSNvctlSSVE 197
Cdd:COG2956      5 VAAALGwyfKGLNYLLNGQPDKAIDLLEEALELDPE---TVEAHLALGNLYRRRGEYDRAIRIHQKLLERDP----DRAE 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  198 IQFHIAHLFeIQNGMArnswcskdicfmvirkhrDRgntilqkqpmnnfyklkafhhkskqlycnswmhhnmdlvgdntt 277
Cdd:COG2956     78 ALLELAQDY-LKAGLL------------------DR-------------------------------------------- 94

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  278 keryAIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICA 357
Cdd:COG2956     95 ----AEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKA 170

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  358 VQLDHGHAAAWMDLGILYESCNQTQDAIKCYLNATRSKscSNTSVLISRIKFLQAQLCNLPQ--SSLQNKTKLLPSIEEA 435
Cdd:COG2956    171 LKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQD--PDYLPALPRLAELYEKLGDPEEalELLRKALELDPSDDLL 248

                          330       340
                   ....*....|....*....|.
gi 1958810387  436 WSLpipAELTSRQGAMNTAQQ 456
Cdd:COG2956    249 LAL---ADLLERKEGLEAALA 266
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 48-186 1.30e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 54.35  E-value: 1.30e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387   48 LLNKAIHCYESLIVKAEGKVESdfFCQLGHFNLLLEDYSKALSSYQRYYSLQTDywklwlvcklrfqqkrdtNAAFLYGL 127
Cdd:COG2956     91 LLDRAEELLEKLLELDPDDAEA--LRLLAEIYEQEGDWEKAIEVLERLLKLGPE------------------NAHAYCEL 150

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958810387  128 GLVYFYYNAFQWAIRAFQEVLYVDPNFCRAK----EIHLRLGfmfkvntDYESSLKHFQLALR 186
Cdd:COG2956    151 AELYLEQGDYDEAIEALEKALKLDPDCARALlllaELYLEQG-------DYEEAIAALERALE 206
MamA NF040959
magnetosome protein MamA; Magnetosomes are special lipid-bound organelles that comprise ...
 22-185 5.84e-05

magnetosome protein MamA; Magnetosomes are special lipid-bound organelles that comprise magnetic mineral crystals in magnetotactic bacteria (MTB). Magnetosomes are important for MTB to search for preferred microaerophilic environment. Proteins of this family typically contain five tetra-trico-peptide repeat (TPR) motifs. Based on structural analyses, MamA forms a large homooligomer through self-recognition to regulate protein-protein interaction in magnetosomes.


Pssm-ID: 468889 [Multi-domain]  Cd Length: 204  Bit Score: 45.45  E-value: 5.84e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387   22 KKALCGLDSSFFGFLSLcKDGVKMKTLLNKAIHC-----YESLIVKAEGKVESDFF-----CQLGHFNLLLEDYSKALSS 91
Cdd:NF040959    15 GRILNNMVNGYNRLFSL-SDRDRAKMYRNKGISHakkgrYDKAVRYLEQVARIDPDdvealYRLGVAYLKTGQYDRAIKV 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387   92 YQRYYSLQTDYWK------LWLVCKLRFQ----------QKRDTNAAFLYGLGLVYFYYNAFQWAIRAFQEVLYVDPNFC 155
Cdd:NF040959    94 LEKVLSLAPDHVKaayrkgVALLKIKDYEkavedleealEEKPDNFNLNYRLGLALDGLGQYDKAIEAFQKALELDPNEI 173

                          170       180       190
                   ....*....|....*....|....*....|
gi 1958810387  156 RakeIHLRLGFMFKVNTDYESSLKHFQLAL 185
Cdd:NF040959   174 K---YHQAIGFMYVQKGDHETAAEHFKKAM 200
TPR_1 pfam00515
Tetratricopeptide repeat;
121-154 2.81e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 39.33  E-value: 2.81e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1958810387  121 AAFLYGLGLVYFYYNAFQWAIRAFQEVLYVDPNF 154
Cdd:pfam00515    1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
 931-995 7.34e-04

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


Pssm-ID: 214721  Cd Length: 58  Bit Score: 38.77  E-value: 7.34e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958810387   931 QLHELTKLPafvrvvSAGNLLSHVGYTILGMNSVQLC-MKVPGSRIPGHQENNNfcSVNINIGPGD 995
Cdd:smart00558    1 QLWNLAKLP------FKLNLLSDLPEDIPGPDVGPYLyMGMAGSTTPWHIDDYD--LVNYLHQGAG 58
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 121-154 7.15e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 35.50  E-value: 7.15e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1958810387   121 AAFLYGLGLVYFYYNAFQWAIRAFQEVLYVDPNF 154
Cdd:smart00028    1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
 
Name Accession Description Interval E-value
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
 965-1073 2.76e-33

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation.


Pssm-ID: 396791  Cd Length: 114  Bit Score: 124.33  E-value: 2.76e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  965 QLCMKVPGSRIPGHQENNNFCSVNINIGPGDCEWFVVPEDYWGVLNDFCEKNN-------LNFLMSSWWPnlEDLYEANV 1037
Cdd:pfam02373    1 WLYLGMPFSTTPWHIEDQGLYSINYLHFGAPKVWYIIPPEYAEKFEKVLSDHFggeqpddLLHLNTIISP--KQLRENGI 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1958810387 1038 PVYRFIQRPGDLVWINAGTVHWVQAIGWCNNITWNV 1073
Cdd:pfam02373   79 PVYRFVQKPGEFVFTFPGWYHQVFNLGFNIAEAVNF 114
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
282-391 1.89e-20

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 91.99  E-value: 1.89e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  282 AIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 361
Cdd:COG0457     27 AIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELD 106

                           90       100       110
                   ....*....|....*....|....*....|
gi 1958810387  362 HGHAAAWMDLGILYESCNQTQDAIKCYLNA 391
Cdd:COG0457    107 PDDAEALYNLGLALLELGRYDEAIEAYERA 136
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 282-388 8.84e-19

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 83.52  E-value: 8.84e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  282 AIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 361
Cdd:COG4235      2 AIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALD 81

                           90       100
                   ....*....|....*....|....*..
gi 1958810387  362 HGHAAAWMDLGILYESCNQTQDAIKCY 388
Cdd:COG4235     82 PDNPEALYLLGLAAFQQGDYAEAIAAW 108
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
290-393 3.43e-18

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 85.44  E-value: 3.43e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  290 LEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWM 369
Cdd:COG0457      1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALN 80

                           90       100
                   ....*....|....*....|....
gi 1958810387  370 DLGILYESCNQTQDAIKCYLNATR 393
Cdd:COG0457     81 NLGLALQALGRYEEALEDYDKALE 104
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
282-388 6.71e-18

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 84.67  E-value: 6.71e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  282 AIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 361
Cdd:COG0457     61 ALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELD 140

                           90       100
                   ....*....|....*....|....*..
gi 1958810387  362 HGHAAAWMDLGILYESCNQTQDAIKCY 388
Cdd:COG0457    141 PDDADALYNLGIALEKLGRYEEALELL 167
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 282-437 2.28e-16

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 84.27  E-value: 2.28e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  282 AIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 361
Cdd:COG3914     97 ALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELD 176

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958810387  362 HGHAAAWMDLGILYESCNQTQDAIKCYLNATRSKscSNTSVLISRIKFLQAQLCNLPQSS-LQNKTKLLPSIEEAWS 437
Cdd:COG3914    177 PDNAEALNNLGNALQDLGRLEEAIAAYRRALELD--PDNADAHSNLLFALRQACDWEVYDrFEELLAALARGPSELS 251
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 121-456 8.71e-16

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 79.00  E-value: 8.71e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  121 AAFLYG---LGLVYFYYNAFQWAIRAFQEVLYVDPNfcrAKEIHLRLGFMFKVNTDYESSLKHFQLALRDSNvctlSSVE 197
Cdd:COG2956      5 VAAALGwyfKGLNYLLNGQPDKAIDLLEEALELDPE---TVEAHLALGNLYRRRGEYDRAIRIHQKLLERDP----DRAE 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  198 IQFHIAHLFeIQNGMArnswcskdicfmvirkhrDRgntilqkqpmnnfyklkafhhkskqlycnswmhhnmdlvgdntt 277
Cdd:COG2956     78 ALLELAQDY-LKAGLL------------------DR-------------------------------------------- 94

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  278 keryAIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICA 357
Cdd:COG2956     95 ----AEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKA 170

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  358 VQLDHGHAAAWMDLGILYESCNQTQDAIKCYLNATRSKscSNTSVLISRIKFLQAQLCNLPQ--SSLQNKTKLLPSIEEA 435
Cdd:COG2956    171 LKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQD--PDYLPALPRLAELYEKLGDPEEalELLRKALELDPSDDLL 248

                          330       340
                   ....*....|....*....|.
gi 1958810387  436 WSLpipAELTSRQGAMNTAQQ 456
Cdd:COG2956    249 LAL---ADLLERKEGLEAALA 266
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 282-391 1.17e-14

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 72.15  E-value: 1.17e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  282 AIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 361
Cdd:COG4783     23 AEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLD 102

                           90       100       110
                   ....*....|....*....|....*....|
gi 1958810387  362 HGHAAAWMDLGILYESCNQTQDAIKCYLNA 391
Cdd:COG4783    103 PEHPEAYLRLARAYRALGRPDEAIAALEKA 132
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 311-442 5.33e-13

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 73.49  E-value: 5.33e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  311 GKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGILYESCNQTQDAIKCYLN 390
Cdd:COG3914     92 GRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRR 171

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958810387  391 ATRSKScSNTSVLISRIKFLQaQLCNLPQS--SLQNKTKLLPSIEEAWSLPIPA 442
Cdd:COG3914    172 ALELDP-DNAEALNNLGNALQ-DLGRLEEAiaAYRRALELDPDNADAHSNLLFA 223
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 282-361 2.06e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 57.12  E-value: 2.06e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  282 AIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 361
Cdd:COG4783     57 AIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELD 136
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
282-361 5.79e-09

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 54.41  E-value: 5.79e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  282 AIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAfVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 361
Cdd:COG3063     11 AEEYYEKALELDPDNADALNNLGLLLLEQGRYDEA-IALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELD 89
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 282-361 9.12e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 55.74  E-value: 9.12e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  282 AIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 361
Cdd:COG5010     73 SLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTS 152
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
293-386 1.83e-08

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 56.46  E-value: 1.83e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  293 DPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLG 372
Cdd:COG4785     69 LPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRG 148

                           90
                   ....*....|....
gi 1958810387  373 ILYESCNQTQDAIK 386
Cdd:COG4785    149 IALYYLGRYELAIA 162
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 282-391 2.10e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 54.58  E-value: 2.10e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  282 AIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 361
Cdd:COG5010     39 EDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALS 118

                           90       100       110
                   ....*....|....*....|....*....|
gi 1958810387  362 HGHAAAWMDLGILYESCNQTQDAIKCYLNA 391
Cdd:COG5010    119 PDNPNAYSNLAALLLSLGQDDEAKAALQRA 148
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 298-393 2.68e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.04  E-value: 2.68e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  298 QSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGILYES 377
Cdd:COG4783      5 EALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLK 84

                           90
                   ....*....|....*.
gi 1958810387  378 CNQTQDAIKCYLNATR 393
Cdd:COG4783     85 AGDYDEALALLEKALK 100
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 74-188 6.88e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 52.32  E-value: 6.88e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387   74 QLGHFNLLLEDYSKALSSYQRYYSLQTDywklwlvcklrfqqkrdtNAAFLYGLGLVYFYYNAFQWAIRAFQEVLYVDPN 153
Cdd:COG4235     22 LLGRAYLRLGRYDEALAAYEKALRLDPD------------------NADALLDLAEALLAAGDTEEAEELLERALALDPD 83

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1958810387  154 FCRAkeiHLRLGFMFKVNTDYESSLKHFQLALRDS 188
Cdd:COG4235     84 NPEA---LYLLGLAAFQQGDYAEAIAAWQKLLALL 115
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 48-186 1.30e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 54.35  E-value: 1.30e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387   48 LLNKAIHCYESLIVKAEGKVESdfFCQLGHFNLLLEDYSKALSSYQRYYSLQTDywklwlvcklrfqqkrdtNAAFLYGL 127
Cdd:COG2956     91 LLDRAEELLEKLLELDPDDAEA--LRLLAEIYEQEGDWEKAIEVLERLLKLGPE------------------NAHAYCEL 150

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958810387  128 GLVYFYYNAFQWAIRAFQEVLYVDPNFCRAK----EIHLRLGfmfkvntDYESSLKHFQLALR 186
Cdd:COG2956    151 AELYLEQGDYDEAIEALEKALKLDPDCARALlllaELYLEQG-------DYEEAIAALERALE 206
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
75-332 3.32e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 53.09  E-value: 3.32e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387   75 LGHFNLLLEDYSKALSSYQRYYSLQTDYWKLWlvcklrfqqkrdtnaaflYGLGLVYFYYNAFQWAIRAFQEVLYVDPNF 154
Cdd:COG0457     14 LGLAYRRLGRYEEAIEDYEKALELDPDDAEAL------------------YNLGLAYLRLGRYEEALADYEQALELDPDD 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  155 CRAkeiHLRLGFMFKVNTDYESSLKHFQLALRdsnvctlssveiqfhiahlFEIQNGMARNSwcskdicfmvirkhrdRG 234
Cdd:COG0457     76 AEA---LNNLGLALQALGRYEEALEDYDKALE-------------------LDPDDAEALYN----------------LG 117

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  235 NTilqkqpmnnFYKLKafhhkskqlycnswmhhnmdlvgdnttkeRY--AIQYLQKSLEEDPNSGQSWYFLGRCYSCIGK 312
Cdd:COG0457    118 LA---------LLELG-----------------------------RYdeAIEAYERALELDPDDADALYNLGIALEKLGR 159

                          250       260
                   ....*....|....*....|
gi 1958810387  313 VQDAFVSYRQSIDKSEASAD 332
Cdd:COG0457    160 YEEALELLEKLEAAALAALL 179
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
311-388 4.23e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 49.01  E-value: 4.23e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958810387  311 GKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQaYICAVQLDHGHAAAWMDLGILYESCNQTQDAIKCY 388
Cdd:COG3063      6 GDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEALAYL 82
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
49-186 9.52e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.55  E-value: 9.52e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387   49 LNKAIHCYESLIVKAEGKVESdfFCQLGHFNLLLEDYSKALSSYQRYYSLQTDywklwlvcklrfqqkrdtNAAFLYGLG 128
Cdd:COG0457     24 YEEAIEDYEKALELDPDDAEA--LYNLGLAYLRLGRYEEALADYEQALELDPD------------------DAEALNNLG 83

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958810387  129 LVYFYYNAFQWAIRAFQEVLYVDPNFCRAK----EIHLRLGfmfkvntDYESSLKHFQLALR 186
Cdd:COG0457     84 LALQALGRYEEALEDYDKALELDPDDAEALynlgLALLELG-------RYDEAIEAYERALE 138
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 49-186 1.64e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 45.95  E-value: 1.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387   49 LNKAIHCYESLIvkAEGKVESDFFCQLGHFNLLLEDYSKALSSYQRYYSLQTDywklwlvcklrfqqkrdtNAAFLYGLG 128
Cdd:COG4783     20 YDEAEALLEKAL--ELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPD------------------EPEARLNLG 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958810387  129 LVYFYYNAFQWAIRAFQEVLYVDPNFcraKEIHLRLGFMFKVNTDYESSLKHFQLALR 186
Cdd:COG4783     80 LALLKAGDYDEALALLEKALKLDPEH---PEAYLRLARAYRALGRPDEAIAALEKALE 134
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 339-393 2.56e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 45.72  E-value: 2.56e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958810387  339 VLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGILYESCNQTQDAIKCYLNATR 393
Cdd:COG5010     62 NLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALA 116
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 282-354 3.53e-05

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 44.21  E-value: 3.53e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958810387  282 AIQYLQKSLEEDPNS---GQSWYFLGRCYSCIGKVQDAFVSYRQSID---KSEASADTWCSIGVLYQQQNQPMDALQAY 354
Cdd:COG1729     12 AIAAFKAFLKRYPNSplaPDALYWLGEAYYALGDYDEAAEAFEKLLKrypDSPKAPDALLKLGLSYLELGDYDKARATL 90
MamA NF040959
magnetosome protein MamA; Magnetosomes are special lipid-bound organelles that comprise ...
 22-185 5.84e-05

magnetosome protein MamA; Magnetosomes are special lipid-bound organelles that comprise magnetic mineral crystals in magnetotactic bacteria (MTB). Magnetosomes are important for MTB to search for preferred microaerophilic environment. Proteins of this family typically contain five tetra-trico-peptide repeat (TPR) motifs. Based on structural analyses, MamA forms a large homooligomer through self-recognition to regulate protein-protein interaction in magnetosomes.


Pssm-ID: 468889 [Multi-domain]  Cd Length: 204  Bit Score: 45.45  E-value: 5.84e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387   22 KKALCGLDSSFFGFLSLcKDGVKMKTLLNKAIHC-----YESLIVKAEGKVESDFF-----CQLGHFNLLLEDYSKALSS 91
Cdd:NF040959    15 GRILNNMVNGYNRLFSL-SDRDRAKMYRNKGISHakkgrYDKAVRYLEQVARIDPDdvealYRLGVAYLKTGQYDRAIKV 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387   92 YQRYYSLQTDYWK------LWLVCKLRFQ----------QKRDTNAAFLYGLGLVYFYYNAFQWAIRAFQEVLYVDPNFC 155
Cdd:NF040959    94 LEKVLSLAPDHVKaayrkgVALLKIKDYEkavedleealEEKPDNFNLNYRLGLALDGLGQYDKAIEAFQKALELDPNEI 173

                          170       180       190
                   ....*....|....*....|....*....|
gi 1958810387  156 RakeIHLRLGFMFKVNTDYESSLKHFQLAL 185
Cdd:NF040959   174 K---YHQAIGFMYVQKGDHETAAEHFKKAM 200
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 74-207 2.18e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.49  E-value: 2.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387   74 QLGHFNLLLEDYSKALSSYQRYYSLQtdywklwlvcklrfqqkrDTNAAFLYGLGLVYFYYNAFQWAIRAFQEVLYVDPN 153
Cdd:COG4783      9 ALAQALLLAGDYDEAEALLEKALELD------------------PDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPD 70

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958810387  154 FcraKEIHLRLGFMFKVNTDYESSLKHFQLALRDSNvctlSSVEIQFHIAHLFE 207
Cdd:COG4783     71 E---PEARLNLGLALLKAGDYDEALALLEKALKLDP----EHPEAYLRLARAYR 117
TPR_1 pfam00515
Tetratricopeptide repeat;
121-154 2.81e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 39.33  E-value: 2.81e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1958810387  121 AAFLYGLGLVYFYYNAFQWAIRAFQEVLYVDPNF 154
Cdd:pfam00515    1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
72-157 6.68e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 42.59  E-value: 6.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387   72 FCQLGHFNLLLEDYSKALSSYQRYYSLQTDYwklwlvcklrfqqkrdtnAAFLYGLGLVYFYYNAFQWAIRAFQEVLYVD 151
Cdd:COG4785    110 YNNRGLAYLLLGDYDAALEDFDRALELDPDY------------------AYAYLNRGIALYYLGRYELAIADLEKALELD 171


                   ....*.
gi 1958810387  152 PNFCRA 157
Cdd:COG4785    172 PNDPER 177
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
 931-995 7.34e-04

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


Pssm-ID: 214721  Cd Length: 58  Bit Score: 38.77  E-value: 7.34e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958810387   931 QLHELTKLPafvrvvSAGNLLSHVGYTILGMNSVQLC-MKVPGSRIPGHQENNNfcSVNINIGPGD 995
Cdd:smart00558    1 QLWNLAKLP------FKLNLLSDLPEDIPGPDVGPYLyMGMAGSTTPWHIDDYD--LVNYLHQGAG 58
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 282-332 8.57e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 40.76  E-value: 8.57e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1958810387  282 AIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASAD 332
Cdd:COG4235     70 AEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAP 120
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 340-413 9.54e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 43.44  E-value: 9.54e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958810387  340 LYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGILYESCNQTQDAIKCYLNATRSKScSNTSVLISRIKFLQAQ 413
Cdd:COG3914     87 LLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNP-DFAEAYLNLGEALRRL 159
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
282-375 3.05e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 40.67  E-value: 3.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958810387  282 AIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 361
Cdd:COG4785     92 AIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELD 171

                           90
                   ....*....|....
gi 1958810387  362 HGHAAAWMDLGILY 375
Cdd:COG4785    172 PNDPERALWLYLAE 185
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
340-386 5.57e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.46  E-value: 5.57e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1958810387  340 LYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGILYESCNQTQDAIK 386
Cdd:COG3063      1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA 47
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 121-154 7.15e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 35.50  E-value: 7.15e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1958810387   121 AAFLYGLGLVYFYYNAFQWAIRAFQEVLYVDPNF 154
Cdd:smart00028    1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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