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Conserved domains on  [gi|1958652567|ref|XP_038956521|]
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zinc finger protein 628 isoform X2 [Rattus norvegicus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
60-570 4.90e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.89  E-value: 4.90e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567  60 RPYKCPDCPKAFKGSSALLYHQRGHTGERPYQCPDCPKAFKRSSLLQIHRSV---HTGLRAFTCGLCGLAFKWSSHYQYH 136
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLrthHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567 137 LRQHTGERPYPCPDCPKAFKNSSSLRRHRHVHTGERPYSCSICGKSFT---QSTNLRqhqrprsPPEPPAPPPQPPPVVP 213
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntpQSNSLH-------PPLPANSLSKDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567 214 EFFLAAAETTVELVYRCDGC-----EQGFSSEELLLEHQPcpGPTVATQPQDvpaeLPQADSALQPPPATTGPSNFA-CL 287
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPlsssySIPSSSSDQNLENSS--SSLPLTTNSQ----LSPKSLLSQSPSSLSSSDSSSsAS 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567 288 PCGKSFQTVAGLSRHQHSHgAASGQAFRCGScdgafpqlasllahqqchveeaaagrpppqaevaevtcpqepvapatpa 367
Cdd:COG5048   259 ESPRSSLPTASSQSSSPNE-SDSSSEKGFSL------------------------------------------------- 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567 368 ppppppapvsaerPYKCAECGKAFKGSSGLRYHLR--DHTGE--RPYQCGE--CGKAFKRSSLLAIHQRVHTGLRAFTC- 440
Cdd:COG5048   289 -------------PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEk 355

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567 441 --------GQCGLTFKWSSHYQYHLRLHSgeRPYACT--ECGKAFRNTSCLRRHRHVHTGERPHSCsvcgksfaqtsnlr 510
Cdd:COG5048   356 llnssskfSPLLNNEPPQSLQQYKDLKND--KKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNC-------------- 419

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567 511 qhqrvhtgerpfRCPLCPKTFTHSSNLLLHQRTHSAERPFACPICGRgFVMAAYLQRHLR 570
Cdd:COG5048   420 ------------KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
60-570 4.90e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.89  E-value: 4.90e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567  60 RPYKCPDCPKAFKGSSALLYHQRGHTGERPYQCPDCPKAFKRSSLLQIHRSV---HTGLRAFTCGLCGLAFKWSSHYQYH 136
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLrthHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567 137 LRQHTGERPYPCPDCPKAFKNSSSLRRHRHVHTGERPYSCSICGKSFT---QSTNLRqhqrprsPPEPPAPPPQPPPVVP 213
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntpQSNSLH-------PPLPANSLSKDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567 214 EFFLAAAETTVELVYRCDGC-----EQGFSSEELLLEHQPcpGPTVATQPQDvpaeLPQADSALQPPPATTGPSNFA-CL 287
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPlsssySIPSSSSDQNLENSS--SSLPLTTNSQ----LSPKSLLSQSPSSLSSSDSSSsAS 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567 288 PCGKSFQTVAGLSRHQHSHgAASGQAFRCGScdgafpqlasllahqqchveeaaagrpppqaevaevtcpqepvapatpa 367
Cdd:COG5048   259 ESPRSSLPTASSQSSSPNE-SDSSSEKGFSL------------------------------------------------- 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567 368 ppppppapvsaerPYKCAECGKAFKGSSGLRYHLR--DHTGE--RPYQCGE--CGKAFKRSSLLAIHQRVHTGLRAFTC- 440
Cdd:COG5048   289 -------------PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEk 355

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567 441 --------GQCGLTFKWSSHYQYHLRLHSgeRPYACT--ECGKAFRNTSCLRRHRHVHTGERPHSCsvcgksfaqtsnlr 510
Cdd:COG5048   356 llnssskfSPLLNNEPPQSLQQYKDLKND--KKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNC-------------- 419

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567 511 qhqrvhtgerpfRCPLCPKTFTHSSNLLLHQRTHSAERPFACPICGRgFVMAAYLQRHLR 570
Cdd:COG5048   420 ------------KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
508-533 8.39e-07

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.83  E-value: 8.39e-07
                          10        20
                  ....*....|....*....|....*.
gi 1958652567 508 NLRQHQRVHTGERPFRCPLCPKTFTH 533
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 131-192 8.55e-04

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 40.24  E-value: 8.55e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958652567 131 SHYQYHLRQHTGERPYPCPDCPKAFKNSSSLRrhRHVHTGERPYSCSICGKSFTQSTNLRQH 192
Cdd:PHA00733   59 SSYLYKLLTSKAVSPYVCPLCLMPFSSSVSLK--QHIRYTEHSKVCPVCGKEFRNTDSTLDH 118
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 496-540 8.03e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.38  E-value: 8.03e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958652567 496 CSVCGKSFAQTSNLRQHQRVHTgerpFRCPLCPKTFTHSSNLLLH 540
Cdd:cd20908     4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
ZnF_C2H2 smart00355
zinc finger;
522-544 9.97e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.36  E-value: 9.97e-03
                           10        20
                   ....*....|....*....|...
gi 1958652567  522 FRCPLCPKTFTHSSNLLLHQRTH 544
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
60-570 4.90e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.89  E-value: 4.90e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567  60 RPYKCPDCPKAFKGSSALLYHQRGHTGERPYQCPDCPKAFKRSSLLQIHRSV---HTGLRAFTCGLCGLAFKWSSHYQYH 136
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLrthHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567 137 LRQHTGERPYPCPDCPKAFKNSSSLRRHRHVHTGERPYSCSICGKSFT---QSTNLRqhqrprsPPEPPAPPPQPPPVVP 213
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntpQSNSLH-------PPLPANSLSKDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567 214 EFFLAAAETTVELVYRCDGC-----EQGFSSEELLLEHQPcpGPTVATQPQDvpaeLPQADSALQPPPATTGPSNFA-CL 287
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPlsssySIPSSSSDQNLENSS--SSLPLTTNSQ----LSPKSLLSQSPSSLSSSDSSSsAS 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567 288 PCGKSFQTVAGLSRHQHSHgAASGQAFRCGScdgafpqlasllahqqchveeaaagrpppqaevaevtcpqepvapatpa 367
Cdd:COG5048   259 ESPRSSLPTASSQSSSPNE-SDSSSEKGFSL------------------------------------------------- 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567 368 ppppppapvsaerPYKCAECGKAFKGSSGLRYHLR--DHTGE--RPYQCGE--CGKAFKRSSLLAIHQRVHTGLRAFTC- 440
Cdd:COG5048   289 -------------PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEk 355

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567 441 --------GQCGLTFKWSSHYQYHLRLHSgeRPYACT--ECGKAFRNTSCLRRHRHVHTGERPHSCsvcgksfaqtsnlr 510
Cdd:COG5048   356 llnssskfSPLLNNEPPQSLQQYKDLKND--KKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNC-------------- 419

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567 511 qhqrvhtgerpfRCPLCPKTFTHSSNLLLHQRTHSAERPFACPICGRgFVMAAYLQRHLR 570
Cdd:COG5048   420 ------------KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
23-183 2.02e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.41  E-value: 2.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567  23 STTPAPTPAAQYECGECGKSFRWSSRLLHHQRTHTGER-PYKCPDCPKAFKGSSALLYHQRG--HTGE--RPYQCP--DC 95
Cdd:COG5048   250 SSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLC 329

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567  96 PKAFKRSSLLQIHRSVHTGLRAFTC------------------------------------GLCGLAFKWSSHY-QYHLR 138
Cdd:COG5048   330 GKLFSRNDALKRHILLHTSISPAKEkllnssskfspllnneppqslqqykdlkndkksetlSNSCIRNFKRDSNlSLHII 409

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1958652567 139 QHTGERPY--PCPDCPKAFKNSSSLRRHRHVHTGERPYSCSICGKSF 183
Cdd:COG5048   410 THLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
417-572 2.06e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 2.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567 417 KAFKRSSLLAIHQRVHTGLRA-FTCGQCGLTFKWSSHYQYHLR--LHSGE--RPYACTE--CGKAFRNTSCLRRHRHVHT 489
Cdd:COG5048   268 ASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567 490 GERPHSC--SVCGKSFAQTSNLRQHQRVH-----TGERPFRCPL--CPKTFTHSSNLLLHQRTHSAERP--FACPICGRG 558
Cdd:COG5048   348 SISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKS 427

                         170
                  ....*....|....
gi 1958652567 559 FVMAAYLQRHLRTH 572
Cdd:COG5048   428 FNRHYNLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
508-533 8.39e-07

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.83  E-value: 8.39e-07
                          10        20
                  ....*....|....*....|....*.
gi 1958652567 508 NLRQHQRVHTGERPFRCPLCPKTFTH 533
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
397-421 5.09e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.90  E-value: 5.09e-06
                          10        20
                  ....*....|....*....|....*
gi 1958652567 397 LRYHLRDHTGERPYQCGECGKAFKR 421
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
132-157 5.95e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 5.95e-06
                          10        20
                  ....*....|....*....|....*.
gi 1958652567 132 HYQYHLRQHTGERPYPCPDCPKAFKN 157
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
52-72 1.29e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 1.29e-05
                          10        20
                  ....*....|....*....|.
gi 1958652567  52 HQRTHTGERPYKCPDCPKAFK 72
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 58-109 1.47e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.56  E-value: 1.47e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958652567  58 GERPYKCP--DCPKAFKGSSALLYHQR-GHTG------------------ERPYQCPDCPKAFKRSSLLQIHR 109
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLhGHQNqklhenpspekmnifsakDKPYRCEVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
76-101 1.54e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 1.54e-05
                          10        20
                  ....*....|....*....|....*.
gi 1958652567  76 ALLYHQRGHTGERPYQCPDCPKAFKR 101
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
160-185 4.22e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 4.22e-05
                          10        20
                  ....*....|....*....|....*.
gi 1958652567 160 SLRRHRHVHTGERPYSCSICGKSFTQ 185
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 522-544 4.43e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 41.13  E-value: 4.43e-05
                          10        20
                  ....*....|....*....|...
gi 1958652567 522 FRCPLCPKTFTHSSNLLLHQRTH 544
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 462-545 4.50e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.02  E-value: 4.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567 462 GERPYAC--TECGKAFRNTSCLRRHR-HVHTGERPHscsvcgksfaQTSNLRQHQRVHTGERPFRCPLCPKTFTHSSNLL 538
Cdd:COG5189   346 DGKPYKCpvEGCNKKYKNQNGLKYHMlHGHQNQKLH----------ENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ....*..
gi 1958652567 539 LHqRTHS 545
Cdd:COG5189   416 YH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
481-505 4.89e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 4.89e-05
                          10        20
                  ....*....|....*....|....*
gi 1958652567 481 LRRHRHVHTGERPHSCSVCGKSFAQ 505
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
452-477 1.06e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 1.06e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958652567 452 HYQYHLRLHSGERPYACTECGKAFRN 477
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 410-432 1.18e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.98  E-value: 1.18e-04
                          10        20
                  ....*....|....*....|...
gi 1958652567 410 YQCGECGKAFKRSSLLAIHQRVH 432
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
427-572 1.63e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 1.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567 427 IHQRVHTGLRAFTCGQCGLTFKWSSHYQYHLRLHSGERPYACTECGKAFRNTSCLRRHRHVHTGERPHSCSVCGKSFAQT 506
Cdd:COG5048   188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958652567 507 SNLRQHQRVHTGER-------PFRCPLCPKTFTHSSNLLLHQRT--HSAE--RPFACPI--CGRGFVMAAYLQRHLRTH 572
Cdd:COG5048   268 ASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLH 346
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 142-192 1.67e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 1.67e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958652567 142 GERPYPCP--DCPKAFKNSSSLRRHR-HVHTG------------------ERPYSCSICGKSFTQSTNLRQH 192
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMlHGHQNqklhenpspekmnifsakDKPYRCEVCDKRYKNLNGLKYH 417
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 146-168 1.87e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.21  E-value: 1.87e-04
                          10        20
                  ....*....|....*....|...
gi 1958652567 146 YPCPDCPKAFKNSSSLRRHRHVH 168
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 494-516 2.23e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.21  E-value: 2.23e-04
                          10        20
                  ....*....|....*....|...
gi 1958652567 494 HSCSVCGKSFAQTSNLRQHQRVH 516
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 90-112 2.79e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 2.79e-04
                          10        20
                  ....*....|....*....|...
gi 1958652567  90 YQCPDCPKAFKRSSLLQIHRSVH 112
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
377-543 4.54e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 4.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567 377 SAERPYKCAECGKAFKGSSGLRYHLRDHTGERPYQCG--ECGKAFKRSSLLAIHQR-VHTGLRAFTCGQCGLTFKWSSHY 453
Cdd:COG5048    29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRtHHNNPSDLNSKSLPLSNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958652567 454 QYHLRLHSGERPYACTECGKAFRNTSCLRRHRHVHTGERPHSCSVCGKSFAQTSN-------LRQHQRVHTGERPFRCPL 526
Cdd:COG5048   109 SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnslhppLPANSLSKDPSSNLSLLI 188

                         170       180
                  ....*....|....*....|.
gi 1958652567 527 C----PKTFTHSSNLLLHQRT 543
Cdd:COG5048   189 SsnvsTSIPSSSENSPLSSSY 209
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
520-572 4.66e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 4.66e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958652567 520 RPFRCPLCPKTFTHSSNLLLHQRTHSAERPFACPICGRG--FVMAAYLQRHLRTH 572
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTH 86
PHA00733 PHA00733
hypothetical protein
 131-192 8.55e-04

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 40.24  E-value: 8.55e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958652567 131 SHYQYHLRQHTGERPYPCPDCPKAFKNSSSLRrhRHVHTGERPYSCSICGKSFTQSTNLRQH 192
Cdd:PHA00733   59 SSYLYKLLTSKAVSPYVCPLCLMPFSSSVSLK--QHIRYTEHSKVCPVCGKEFRNTDSTLDH 118
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 379-433 1.08e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 1.08e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958652567 379 ERPYKCA--ECGKAFKGSSGLRYH-LRDHTG------------------ERPYQCGECGKAFKRSSLLAIHqRVHT 433
Cdd:COG5189   347 GKPYKCPveGCNKKYKNQNGLKYHmLHGHQNqklhenpspekmnifsakDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 466-488 2.47e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 2.47e-03
                          10        20
                  ....*....|....*....|...
gi 1958652567 466 YACTECGKAFRNTSCLRRHRHVH 488
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 550-572 2.61e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 2.61e-03
                          10        20
                  ....*....|....*....|...
gi 1958652567 550 FACPICGRGFVMAAYLQRHLRTH 572
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 62-84 3.31e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 3.31e-03
                          10        20
                  ....*....|....*....|...
gi 1958652567  62 YKCPDCPKAFKGSSALLYHQRGH 84
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 382-404 6.32e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 6.32e-03
                          10        20
                  ....*....|....*....|...
gi 1958652567 382 YKCAECGKAFKGSSGLRYHLRDH 404
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
InsA COG3677
Transposase InsA [Mobilome: prophages, transposons];
131-188 7.10e-03

Transposase InsA [Mobilome: prophages, transposons];


Pssm-ID: 442893 [Multi-domain]  Cd Length: 241  Bit Score: 39.47  E-value: 7.10e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958652567 131 SHYQYHLRQHTGERPYPCPDCpkafkNSSSLRRHRHVHTGERPYSCSICGKSFTQSTN 188
Cdd:COG3677     2 STAEELLEQIRWPNGPVCPHC-----GSTRIVKNGKTRNGRQRYRCKDCGRTFTVTTG 54
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 496-540 8.03e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.38  E-value: 8.03e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958652567 496 CSVCGKSFAQTSNLRQHQRVHTgerpFRCPLCPKTFTHSSNLLLH 540
Cdd:cd20908     4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 174-192 9.28e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 9.28e-03
                          10
                  ....*....|....*....
gi 1958652567 174 YSCSICGKSFTQSTNLRQH 192
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRH 19
ZnF_C2H2 smart00355
zinc finger;
522-544 9.97e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.36  E-value: 9.97e-03
                           10        20
                   ....*....|....*....|...
gi 1958652567  522 FRCPLCPKTFTHSSNLLLHQRTH 544
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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