|
Name |
Accession |
Description |
Interval |
E-value |
| iduronate-2-sulfatase |
cd16030 |
iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the ... |
1-411 |
2.83e-139 |
|
iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the hydrolysis of sulfate ester bonds from a wide variety of substrates, including steroids, carbohydrates and proteins. Iduronate 2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in the iduronate 2-sulfatase gene that result in enzymatic deficiency lead to the sex-linked mucopolysaccharidosis type II, also known as Hunter syndrome.
Pssm-ID: 293754 [Multi-domain] Cd Length: 435 Bit Score: 405.03 E-value: 2.83e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 1 MSVGKVFHPGISSNhsDDYPYSWSFPPYHPSSEKYENTKTCKGQDGKLHTNLLCPVDVADVPEGTLPDKQSTEEAIRLLE 80
Cdd:cd16030 97 AGVGKIFHPGIPDG--DDDPASWDEPPNPPGPEKYPPGKLCPGKKGGKGGGGGPAWEAADVPDEAYPDGKVADEAIEQLR 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 81 KMKTSVSPFFLAVGYHKPHIPFRYPKEFQKLYPLENMTLaPDPHVPDSLPPVAYNPWMDIREREDVQALNISVPYGPIPV 160
Cdd:cd16030 175 KLKDSDKPFFLAVGFYKPHLPFVAPKKYFDLYPLESIPL-PNPFDPIDLPEVAWNDLDDLPKYGDIPALNPGDPKGPLPD 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 161 DFQRKIRQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWALGEHGEWAKYSNFDVTTRVPLMFYVPGKTAll 240
Cdd:cd16030 254 EQARELRQAYYASVSYVDAQVGRVLDALEELGLADNTIVVLWSDHGWHLGEHGHWGKHTLFEEATRVPLIIRAPGVTK-- 331
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 241 paageklfpyqdpfdpaselmgAGRRTEDLVELVSLFPTLAGLAGMPVPPwcpipsfhvelCREGHNLQRYLQlhdleeD 320
Cdd:cd16030 332 ----------------------PGKVTDALVELVDIYPTLAELAGLPAPP-----------CLEGKSLVPLLK------N 372
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 321 PylfGNPRELIAYSQYPRPAdfpqwnsdkpslkdikVMGYSIRTIDYRYTVWVgfspteflaNFSDIHAGELYFVDSDPL 400
Cdd:cd16030 373 P---SAKWKDAAFSQYPRPS----------------IMGYSIRTERYRYTEWV---------DFDKVGAEELYDHKNDPN 424
|
410
....*....|.
gi 1958809850 401 QDHNVYNDSQH 411
Cdd:cd16030 425 EWKNLANDPEY 435
|
|
| AslA |
COG3119 |
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism]; |
72-408 |
1.33e-49 |
|
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];
Pssm-ID: 442353 [Multi-domain] Cd Length: 393 Bit Score: 172.76 E-value: 1.33e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 72 TEEAIRLLEKMKTSVSPFFLAVGYHKPHIPFRYPKEFQKLYPLENMTLapdphvPDSLPPVAYNPWmdireredvqalni 151
Cdd:COG3119 134 TDKAIDFLERQADKDKPFFLYLAFNAPHAPYQAPEEYLDKYDGKDIPL------PPNLAPRDLTEE-------------- 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 152 svpygpipvdFQRKIRQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWALGEHG-EWAKYSNFDVTTRVPLM 230
Cdd:COG3119 194 ----------ELRRARAAYAAMIEEVDDQVGRLLDALEELGLADNTIVVFTSDNGPSLGEHGlRGGKGTLYEGGIRVPLI 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 231 FYVPGKTAllpaageklfpyqdpfdpaselmgAGRRTEDLVELVSLFPTLAGLAGMPVPPWCpipsfhvelcrEGHNLQR 310
Cdd:COG3119 264 VRWPGKIK------------------------AGSVSDALVSLIDLLPTLLDLAGVPIPEDL-----------DGRSLLP 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 311 YLQLHDLEEDPYLfgnpreliaYSQYPRPAdfpqwnsdkpslkdikvMGYSIRTIDYRYTVWVGFSPTEflanfsdihag 390
Cdd:COG3119 309 LLTGEKAEWRDYL---------YWEYPRGG-----------------GNRAIRTGRWKLIRYYDDDGPW----------- 351
|
330
....*....|....*...
gi 1958809850 391 ELYFVDSDPLQDHNVYND 408
Cdd:COG3119 352 ELYDLKNDPGETNNLAAD 369
|
|
| sulfatase_like |
cd16033 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
72-419 |
9.51e-36 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293757 [Multi-domain] Cd Length: 411 Bit Score: 135.81 E-value: 9.51e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 72 TEEAIRLLEKMKTSVSPFFLAVGYHKPHIPFRYPKEFQKLYPLENMTLAPDPHVPDSLPPVAYNpwmDIREREDVQALNI 151
Cdd:cd16033 133 ADRAIEMLEELAADDKPFFLRVNFWGPHDPYIPPEPYLDMYDPEDIPLPESFADDFEDKPYIYR---RERKRWGVDTEDE 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 152 SVpygpipvdfQRKIRQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWALGEHGEWAK-YSNFDVTTRVPLM 230
Cdd:cd16033 210 ED---------WKEIIAHYWGYITLIDDAIGRILDALEELGLADDTLVIFTSDHGDALGAHRLWDKgPFMYEETYRIPLI 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 231 FYVPGKTAllpaageklfpyqdpfdpaselmgAGRRTEDLVELVSLFPTLAGLAGMPVPpwcpiPSFHvelcreGHNLQr 310
Cdd:cd16033 281 IKWPGVIA------------------------AGQVVDEFVSLLDLAPTILDLAGVDVP-----PKVD------GRSLL- 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 311 ylqlhdleedPYLFGNPRELIaysqypRPADFPQWNSDKPSLkdikvMGYSIRTIDYRYTVwvgfspteflaNFSDIhaG 390
Cdd:cd16033 325 ----------PLLRGEQPEDW------RDEVVTEYNGHEFYL-----PQRMVRTDRYKYVF-----------NGFDI--D 370
|
330 340
....*....|....*....|....*....
gi 1958809850 391 ELYFVDSDPLQDHNVYNDSQHGGLLLSLR 419
Cdd:cd16033 371 ELYDLESDPYELNNLIDDPEYEEILREMR 399
|
|
| sulfatase_like |
cd16155 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
72-328 |
5.59e-34 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293774 [Multi-domain] Cd Length: 372 Bit Score: 130.38 E-value: 5.59e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 72 TEEAIRLLEKMKTSVSPFFLAVGYHKPHIPFRYPKEFQKLYPLENMTLaPDPHVPdsLPPVAyNPWMDIRereDVQalni 151
Cdd:cd16155 108 ADAAIEFLEEYKDGDKPFFMYVAFTAPHDPRQAPPEYLDMYPPETIPL-PENFLP--QHPFD-NGEGTVR---DEQ---- 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 152 svpYGPIPVDFQ--RKIRQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWALGEHGEWAKYSNFDVTTRVPL 229
Cdd:cd16155 177 ---LAPFPRTPEavRQHLAEYYAMITHLDAQIGRILDALEASGELDNTIIVFTSDHGLAVGSHGLMGKQNLYEHSMRVPL 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 230 MFYVPGKTallpaageklfpyqdpfdpaselmgAGRRTEDLVELVSLFPTLAGLAGMPVPPWCPIPSF-----------H 298
Cdd:cd16155 254 IISGPGIP-------------------------KGKRRDALVYLQDVFPTLCELAGIEIPESVEGKSLlpvirgekkavR 308
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1958809850 299 VELC-----------REGHNLQRY------LQLHDLEEDPY----LFGNPR 328
Cdd:cd16155 309 DTLYgayrdgqrairDDRWKLIIYvpgvkrTQLFDLKKDPDelnnLADEPE 359
|
|
| sulfatase_like |
cd16037 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
46-399 |
4.58e-32 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293760 [Multi-domain] Cd Length: 321 Bit Score: 123.81 E-value: 4.58e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 46 GKLHTNllcpvdVADVPEGTLPDKQSTEEAIRLLEKMKTSVSPFFLAVGYHKPHIPFRYPKEFQKLYplenmtlapdphv 125
Cdd:cd16037 96 GKLHFR------GEDQRHGFRYDRDVTEAAVDWLREEAADDKPWFLFVGFVAPHFPLIAPQEFYDLY------------- 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 126 pdslppvaynpwmdireredvqalnisvpygpipvdfQRKIRQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDH 205
Cdd:cd16037 157 -------------------------------------VRRARAAYYGLVEFLDENIGRVLDALEELGLLDNTLIIYTSDH 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 206 GWALGEHGEWAKYSNFDVTTRVPLMFYVPGktallpaageklfpyqdpfdpaselMGAGRRTEDLVELVSLFPTLAGLAG 285
Cdd:cd16037 200 GDMLGERGLWGKSTMYEESVRVPMIISGPG-------------------------IPAGKRVKTPVSLVDLAPTILEAAG 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 286 MPVPPWCPipsfhvelcreGHNLQrylqlhDLEEDPYlfgnPRELIAYSQYprpadfpqwnsdkpSLKDIKVMGYSIRTI 365
Cdd:cd16037 255 APPPPDLD-----------GRSLL------PLAEGPD----DPDRVVFSEY--------------HAHGSPSGAFMLRKG 299
|
330 340 350
....*....|....*....|....*....|....
gi 1958809850 366 DYRYTVWVGFSPteflanfsdihagELYFVDSDP 399
Cdd:cd16037 300 RWKYIYYVGYPP-------------QLFDLENDP 320
|
|
| PRK13759 |
PRK13759 |
arylsulfatase; Provisional |
60-290 |
9.43e-32 |
|
arylsulfatase; Provisional
Pssm-ID: 237491 [Multi-domain] Cd Length: 485 Bit Score: 125.94 E-value: 9.43e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 60 DVPEGTLPDKQSTEEAIRLLEKmKTSVSPFFLAVGYHKPHIPFRYPKEFQKLYplENmTLAPDPHVPDslppvaynpWmD 139
Cdd:PRK13759 174 DLEERLHPTNWVGSESIEFLRR-RDPTKPFFLKMSFARPHSPYDPPKRYFDMY--KD-ADIPDPHIGD---------W-E 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 140 IREREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWALGEHGEWAKYS 219
Cdd:PRK13759 240 YAEDQDPEGGSIDALRGNLGEEYARRARAAYYGLITHIDHQIGRFLQALKEFGLLDNTIILFVSDHGDMLGDHYLFRKGY 319
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958809850 220 NFDVTTRVPLMFYVPGktALLPAageklfpyqdpfdpaselmGAGRRTEDLVELVSLFPTLAGLAGMPVPP 290
Cdd:PRK13759 320 PYEGSAHIPFIIYDPG--GLLAG-------------------NRGTVIDQVVELRDIMPTLLDLAGGTIPD 369
|
|
| sulfatase_like |
cd16034 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
57-404 |
1.28e-30 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293758 [Multi-domain] Cd Length: 399 Bit Score: 121.52 E-value: 1.28e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 57 DVADVPEGTLPDKQsTEEAIRLLEKMKTSVSPFFLAVGYHKPHIPFRY-PKEFQKLYPLENMTLAPDphVPdslppvayn 135
Cdd:cd16034 146 GKRIYIKGYSPDAE-TDLAIEYLENQADKDKPFALVLSWNPPHDPYTTaPEEYLDMYDPKKLLLRPN--VP--------- 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 136 PWMDIRERedvqalnisvpygpipvdFQRKIRQsYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWALGEHGEW 215
Cdd:cd16034 214 EDKKEEAG------------------LREDLRG-YYAMITALDDNIGRLLDALKELGLLENTIVVFTSDHGDMLGSHGLM 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 216 AKYSNFDVTTRVPLMFYVPGKtallpaageklfpyqdpfdpaselMGAGRRTEDLVELVSLFPTLAGLAGMPVPPWCpip 295
Cdd:cd16034 275 NKQVPYEESIRVPFIIRYPGK------------------------IKAGRVVDLLINTVDIMPTLLGLCGLPIPDTV--- 327
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 296 sfhvelcrEGHNLQrylqlhdleedPYLFGNPRELIAYSQYPRPADFPQWNSDKPSLKDIkvmgysIRTIDYRYTVWVGf 375
Cdd:cd16034 328 --------EGRDLS-----------PLLLGGKDDEPDSVLLQCFVPFGGGSARDGGEWRG------VRTDRYTYVRDKN- 381
|
330 340 350
....*....|....*....|....*....|.
gi 1958809850 376 spteflanfsdihaGELYFVD--SDPLQDHN 404
Cdd:cd16034 382 --------------GPWLLFDneKDPYQLNN 398
|
|
| G6S_like |
cd16031 |
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); ... |
72-419 |
2.56e-30 |
|
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficiency of N-acetylglucosamine-6-sulfatase results in the disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease.
Pssm-ID: 293755 [Multi-domain] Cd Length: 429 Bit Score: 121.10 E-value: 2.56e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 72 TEEAIRLLEKMKTSvSPFFLAVGYHKPHIPFRYPKEFQKLYPLENM----TLAPDPHvpDSLPPVAYNPWMDIREREDVQ 147
Cdd:cd16031 149 TDKALDFLKERDKD-KPFCLSLSFKAPHRPFTPAPRHRGLYEDVTIpepeTFDDDDY--AGRPEWAREQRNRIRGVLDGR 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 148 ALNisvpygpiPVDFQRKIRQsYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWALGEHGeWA-KYSNFDVTTR 226
Cdd:cd16031 226 FDT--------PEKYQRYMKD-YLRTVTGVDDNVGRILDYLEEQGLADNTIIIYTSDNGFFLGEHG-LFdKRLMYEESIR 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 227 VPLMFYVPGKTAllpaageklfpyqdpfdpaselmgAGRRTEDLVELVSLFPTLAGLAGMPVPpwcpiPSFHvelcreGH 306
Cdd:cd16031 296 VPLIIRDPRLIK------------------------AGTVVDALVLNIDFAPTILDLAGVPIP-----EDMQ------GR 340
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 307 NLqryLQLHDLEEDPylfgNPRE--LIAYSQYPRPADFPQWnsdkpslkdikvmgYSIRTIDYRYTVWVGFSPTEflanf 384
Cdd:cd16031 341 SL---LPLLEGEKPV----DWRKefYYEYYEEPNFHNVPTH--------------EGVRTERYKYIYYYGVWDEE----- 394
|
330 340 350
....*....|....*....|....*....|....*
gi 1958809850 385 sdihagELYFVDSDPLQDHNVYNDSQHGGLLLSLR 419
Cdd:cd16031 395 ------ELYDLKKDPLELNNLANDPEYAEVLKELR 423
|
|
| choline-sulfatase |
cd16032 |
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from ... |
88-293 |
7.21e-30 |
|
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from choline. The symbiotic soil bacterium Rhizobium meliloti can synthesize glycine betaine from choline-O-sulphate and choline to protect itself from osmotic stress. This biosynthetic pathway is encoded by the betICBA locus, which comprises a regulatory gene, betI, and three structural genes, betC (choline sulfatase), betB (betaine aldehyde dehydrogenase), and betA (choline dehydrogenase). betICBA genes constitute a single operon.
Pssm-ID: 293756 [Multi-domain] Cd Length: 327 Bit Score: 118.06 E-value: 7.21e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 88 PFFLAVGYHKPHIPFRYPKEFQKLYplenmtlapdphvpdslppvaynpwmdireredvqalnisvpygpipvdfQRKIR 167
Cdd:cd16032 134 PFFLTVSFTHPHDPYVIPQEYWDLY--------------------------------------------------VRRAR 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 168 QSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWALGEHGEWAKYSNFDVTTRVPLMFYVPGKTallpaagekl 247
Cdd:cd16032 164 RAYYGMVSYVDDKVGQLLDTLERTGLADDTIVIFTSDHGDMLGERGLWYKMSFFEGSARVPLIISAPGRF---------- 233
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1958809850 248 fpyqdpfdpaselmgAGRRTEDLVELVSLFPTLAGLAGMPVPPWCP 293
Cdd:cd16032 234 ---------------APRRVAEPVSLVDLLPTLVDLAGGGTAPHVP 264
|
|
| SGSH |
cd16027 |
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) ... |
88-419 |
8.18e-29 |
|
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) belongs to the sulfatase family and catalyses the cleavage of N-linked sulfate groups from the GAGs heparin sulfate and heparin. The active site is characterized by the amino-acid sequence motif C(X)PSR that is highly conserved among most sulfatases. The cysteine residue is post-translationally converted to a formylglycine (FGly) residue, which is crucial for the catalytic process. Loss of function of SGSH results a disease called mucopolysaccharidosis type IIIA (Sanfilippo A syndrome), a fatal childhood-onset neurodegenerative disease with mild facial, visceral and skeletal abnormalities.
Pssm-ID: 293751 [Multi-domain] Cd Length: 373 Bit Score: 116.07 E-value: 8.18e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 88 PFFLAVGYHKPHIPFRYPKEFQKLYPLENMTLapDPHVPDsLPPVaynpwmdireREDVQAlnisvpygpipvdfqrkir 167
Cdd:cd16027 143 PFFLWFGFHDPHRPYPPGDGEEPGYDPEKVKV--PPYLPD-TPEV----------REDLAD------------------- 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 168 qsYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWALGehgeWAKYSNFDVTTRVPLMFYVPGKTAllpaagekl 247
Cdd:cd16027 191 --YYDEIERLDQQVGEILDELEEDGLLDNTIVIFTSDHGMPFP----RAKGTLYDSGLRVPLIVRWPGKIK--------- 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 248 fpyqdpfdpaselmgAGRRTEDLVELVSLFPTLAGLAGMPVPPWcpipsfhvelcREGHNLQRYLQLHDLEEDPYLFGNp 327
Cdd:cd16027 256 ---------------PGSVSDALVSFIDLAPTLLDLAGIEPPEY-----------LQGRSFLPLLKGEKDPGRDYVFAE- 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 328 RELIAYSQYP-RpadfpqwnsdkpslkdikvmgySIRTIDYRYTVwvgfspteflaNFSDIhagELYFVDSDPLQDHNVY 406
Cdd:cd16027 309 RDRHDETYDPiR----------------------SVRTGRYKYIR-----------NYMPE---ELYDLKNDPDELNNLA 352
|
330
....*....|...
gi 1958809850 407 NDSQHGGLLLSLR 419
Cdd:cd16027 353 DDPEYAEVLEELR 365
|
|
| sulfatase_like |
cd16150 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
88-419 |
1.56e-26 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293769 [Multi-domain] Cd Length: 423 Bit Score: 110.40 E-value: 1.56e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 88 PFFLAVGYHKPHIPFRYPKEFQKLYPLEnmtLAPdPHVPDSLPPVAYNPWMDIREREDVQALNisvpygpipVDFQRKIR 167
Cdd:cd16150 133 PFCLYLPLIFPHPPYGVEEPWFSMIDRE---KLP-PRRPPGLRAKGKPSMLEGIEKQGLDRWS---------EERWRELR 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 168 QSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWALGEHGEWAKYSN-F-DVTTRVPLMFYVPGKTallpaage 245
Cdd:cd16150 200 ATYLGMVSRLDHQFGRLLEALKETGLYDDTAVFFFSDHGDYTGDYGLVEKWPNtFeDCLTRVPLIIKPPGGP-------- 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 246 klfpyqdpfdpaselmgAGRRTEDLVELVSLFPTLAGLAGMPVPPwcpiPSFHVELCReghnlqrylQLHDLEEDP--YL 323
Cdd:cd16150 272 -----------------AGGVSDALVELVDIPPTLLDLAGIPLSH----THFGRSLLP---------VLAGETEEHrdAV 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 324 FG----NPRELIAYSQYPRPADFPQWNS---DKPSLKDIKVMgysIRTIDYRYtVWVGFSPTeflanfsdihagELYFVD 396
Cdd:cd16150 322 FSeggrLHGEEQAMEGGHGPYDLKWPRLlqqEEPPEHTKAVM---IRTRRYKY-VYRLYEPD------------ELYDLE 385
|
330 340
....*....|....*....|...
gi 1958809850 397 SDPLQDHNVYNDSQHGGLLLSLR 419
Cdd:cd16150 386 ADPLELHNLIGDPAYAEIIAEMK 408
|
|
| sulfatase_like |
cd16022 |
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, ... |
73-292 |
4.77e-26 |
|
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293746 [Multi-domain] Cd Length: 236 Bit Score: 105.21 E-value: 4.77e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 73 EEAIRLLEKMKTSvSPFFLAVGYHKPHIPFRYpkefqklyplenmtlapdphvpdslppvaynpwmdireredvqalnis 152
Cdd:cd16022 103 DEAIDFIERRDKD-KPFFLYVSFNAPHPPFAY------------------------------------------------ 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 153 vpygpipvdfqrkirqsyFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWALGEHGE-WAKYSNFDVTTRVPLMF 231
Cdd:cd16022 134 ------------------YAMVSAIDDQIGRILDALEELGLLDNTLIVFTSDHGDMLGDHGLrGKKGSLYEGGIRVPFIV 195
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958809850 232 YVPGKtallpaageklfpyqdpfdpaselMGAGRRTEDLVELVSLFPTLAGLAGMPVPPWC 292
Cdd:cd16022 196 RWPGK------------------------IPAGQVSDALVSLLDLLPTLLDLAGIEPPEGL 232
|
|
| ARS_like |
cd16146 |
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide ... |
72-408 |
5.24e-22 |
|
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293765 [Multi-domain] Cd Length: 409 Bit Score: 97.24 E-value: 5.24e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 72 TEEAIRLLEKMKTSvsPFFLAVGYHKPHIPFRYPKEFQKLYplENMTLAPDphvpdslppvaynpwmdireredvqalni 151
Cdd:cd16146 160 FDEAIDFIEENKDK--PFFAYLATNAPHGPLQVPDKYLDPY--KDMGLDDK----------------------------- 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 152 svpygpipvdfqrkiRQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWALGEHGEW------AKYSNFDVTT 225
Cdd:cd16146 207 ---------------LAAFYGMIENIDDNVGRLLAKLKELGLEENTIVIFMSDNGPAGGVPKRFnagmrgKKGSVYEGGH 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 226 RVPLMFYVPGKTAllpaageklfpyqdpfdpaselmgAGRRTEDLVELVSLFPTLAGLAGMPVPPWCPIpsfhvelcrEG 305
Cdd:cd16146 272 RVPFFIRWPGKIL------------------------AGKDVDTLTAHIDLLPTLLDLCGVKLPEGIKL---------DG 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 306 HNLQRYLQlhdLEEDPYlfgNPRELIAYSQYPRPADFPQWNSdkpslkdikvmgySIRTIDYRYTVWVGFSPteflanfs 385
Cdd:cd16146 319 RSLLPLLK---GESDPW---PERTLFTHSGRWPPPPKKKRNA-------------AVRTGRWRLVSPKGFQP-------- 371
|
330 340
....*....|....*....|...
gi 1958809850 386 dihagELYFVDSDPLQDHNVYND 408
Cdd:cd16146 372 -----ELYDIENDPGEENDVADE 389
|
|
| PMH |
cd16028 |
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase ... |
72-313 |
7.63e-22 |
|
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase/phosphodiesterase hydrolyses phosphonate monoesters or phosphate diesters using a posttranslationally formed formylglycine as the catalytic nucleophile. PMH is the member of the alkaline phosphatase superfamily. The structure of PMH is more homologous to arylsulfatase than alkaline phosphatase. Sulfatases also use formylglycine as catalytic nucleophile.
Pssm-ID: 293752 [Multi-domain] Cd Length: 449 Bit Score: 96.94 E-value: 7.63e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 72 TEEAIRLLEKMKTSvsPFFLAVGYHKPHIPFRYPKEFQKLYPLENMTL---APDPHVPDSLPPVaYNPWMDIREREDVQA 148
Cdd:cd16028 144 TDRAIEYLDERQDE--PWFLHLSYIRPHPPFVAPAPYHALYDPADVPPpirAESLAAEAAQHPL-LAAFLERIESLSFSP 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 149 LNISVPYGPIPVdfQRKIRQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWALGEHGEWAKYSNFDVTTRVP 228
Cdd:cd16028 221 GAANAADLDDEE--VAQMRATYLGLIAEVDDHLGRLFDYLKETGQWDDTLIVFTSDHGEQLGDHWLWGKDGFFDQAYRVP 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 229 LMFYVPGKTAllpaageklfpyqdpfDPASelmgaGRRTEDLVELVSLFPTLAGLAGMPVPPWCpipsfhvelcrEGHNL 308
Cdd:cd16028 299 LIVRDPRREA----------------DATR-----GQVVDAFTESVDVMPTILDWLGGEIPHQC-----------DGRSL 346
|
....*
gi 1958809850 309 QRYLQ 313
Cdd:cd16028 347 LPLLA 351
|
|
| sulfatase_like |
cd16148 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
170-290 |
3.81e-21 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293767 [Multi-domain] Cd Length: 271 Bit Score: 92.23 E-value: 3.81e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 170 YFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWALGEHGEWAK-YSNF-DVTTRVPLMFYVPGKTallpaagekl 247
Cdd:cd16148 165 YDAEVRYVDEQIGRLLDKLKELGLLEDTLVIVTSDHGEEFGEHGLYWGhGSNLyDEQLHVPLIIRWPGKE---------- 234
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1958809850 248 fpyqdpfdpaselmgAGRRTEDLVELVSLFPTLAGLAGMPVPP 290
Cdd:cd16148 235 ---------------PGKRVDALVSHIDIAPTLLDLLGVEPPD 262
|
|
| sulfatase_like |
cd16153 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
68-288 |
8.48e-20 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293772 [Multi-domain] Cd Length: 282 Bit Score: 88.59 E-value: 8.48e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 68 DKQSTEEAIRLLEKMKTSVSPFFLAVGYHKPHIPFRYPKEFqklyplenmtlapdphvpdslppvaynpwmdiREREDvq 147
Cdd:cd16153 124 ANQSYKSFWGKIAKGADSDKPFFVRLSFLQPHTPVLPPKEF--------------------------------RDRFD-- 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 148 alnisvpygpipvdfqrkirqsYFASVSYLDTQVGHLLSALDDLRLAH---NTIIAFMSDHGWALGEHGEWAKYSNFDVT 224
Cdd:cd16153 170 ----------------------YYAFCAYGDAQVGRAVEAFKAYSLKQdrdYTIVYVTGDHGWHLGEQGILAKFTFWPQS 227
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958809850 225 TRVPLMFYVPGKTAllpaageklfpyqdpfdpaselMGAGRRTEDLVELVSLFPTLAGLAGMPV 288
Cdd:cd16153 228 HRVPLIVVSSDKLK----------------------APAGKVRHDFVEFVDLAPTLLAAAGVDV 269
|
|
| sulfatase_like |
cd16149 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
170-297 |
3.17e-18 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293768 [Multi-domain] Cd Length: 257 Bit Score: 83.83 E-value: 3.17e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 170 YFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWALGEHGEWAK------YSNFDVTTRVPLMFYVPGKTAllpaa 243
Cdd:cd16149 144 YFAAVTGVDRNVGRLLDELEELGLTENTLVIFTSDNGFNMGHHGIWGKgngtfpLNMYDNSVKVPFIIRWPGVVP----- 218
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1958809850 244 geklfpyqdpfdpaselmgAGRRTEDLVELVSLFPTLAGLAGMPVP--PWCPIPSF 297
Cdd:cd16149 219 -------------------AGRVVDSLVSAYDFFPTLLELAGVDPPadPRLPGRSF 255
|
|
| G6S |
cd16147 |
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); ... |
72-322 |
1.24e-17 |
|
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficient of N-acetylglucosamine-6-sulfatase results in disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease. SULF1 encodes an extracellular heparan sulfate endosulfatase, that removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs).
Pssm-ID: 293766 [Multi-domain] Cd Length: 396 Bit Score: 84.14 E-value: 1.24e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 72 TEEAIRLLEKMKTSVSPFFLAVGYHKPHIPFRYPKEFQKLYPleNMTLAP-----------DPHVPDSLPPvaynPWMDI 140
Cdd:cd16147 160 ANKALDFLRRAAADDKPFFLVVAPPAPHGPFTPAPRYANLFP--NVTAPPrpppnnpdvsdKPHWLRRLPP----LNPTQ 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 141 REREDvqalnisvpygpipvDFQRKIRQSyFASVsylDTQVGHLLSALDDLRLAHNTIIAFMSDHGWALGEHG-EWAKYS 219
Cdd:cd16147 234 IAYID---------------ELYRKRLRT-LQSV---DDLVERLVNTLEATGQLDNTYIIYTSDNGYHLGQHRlPPGKRT 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 220 NFDVTTRVPLMFYVPGktallpaageklfpyqdpfdpaselMGAGRRTEDLVELVSLFPTLAGLAGMPVPPW-------- 291
Cdd:cd16147 295 PYEEDIRVPLLVRGPG-------------------------IPAGVTVDQLVSNIDLAPTILDLAGAPPPSDmdgrscgd 349
|
250 260 270
....*....|....*....|....*....|....*...
gi 1958809850 292 CPIPSFH-VELCREGHNLQ------RYLQLHDLEEDPY 322
Cdd:cd16147 350 SNNNTYKcVRTVDDTYNLLyfewctGFRELYDLTTDPY 387
|
|
| ARS_like |
cd16144 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
55-290 |
1.34e-16 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293763 [Multi-domain] Cd Length: 421 Bit Score: 81.05 E-value: 1.34e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 55 PVDVADVPEGTLPDKQSTEEAIRLLEKMKTSvsPFFLAVGYHKPHIPFRYPKEFQKLYplenmtlapdphvpdslppvay 134
Cdd:cd16144 154 NPDLEDGPEGEYLTDRLTDEAIDFIEQNKDK--PFFLYLSHYAVHTPIQARPELIEKY---------------------- 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 135 npwmdireredvqalnisvpYGPIPVDFQRKIRQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGwALGEHGE 214
Cdd:cd16144 210 --------------------EKKKKGLRKGQKNPVYAAMIESLDESVGRILDALEELGLADNTLVIFTSDNG-GLSTRGG 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 215 WA---------KYSNFDVTTRVPLMFYVPGKTAllpaageklfpyqdpfdpaselmgAGRRTEDLVELVSLFPTLAGLAG 285
Cdd:cd16144 269 PPtsnaplrggKGSLYEGGIRVPLIVRWPGVIK------------------------PGSVSDVPVIGTDLYPTFLELAG 324
|
....*
gi 1958809850 286 MPVPP 290
Cdd:cd16144 325 GPLPP 329
|
|
| sulfatase_like |
cd16035 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
68-289 |
6.97e-16 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293759 [Multi-domain] Cd Length: 311 Bit Score: 78.02 E-value: 6.97e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 68 DKQSTEEAIRLLEKMKTSVS---PFFLAVGYHKPHipfrypkefqklyplenmtlapdphvpdslppvaynpwmdirere 144
Cdd:cd16035 116 DPGIAAQAVEWLRERGAKNAdgkPWFLVVSLVNPH--------------------------------------------- 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 145 DVQalnisvpYGPIPVDFQRKIRQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWALGEHGEWAKYSN-FDV 223
Cdd:cd16035 151 DIM-------FPPDDEERWRRFRNFYYNLIRDVDRQIGRVLDALDASGLADNTIVVFTSDHGEMGGAHGLRGKGFNaYEE 223
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958809850 224 TTRVPLMFYVPgktallpaageklfpyqdpfdpasELMGAGRRTEDLVELVSLFPTLAGLAGMPVP 289
Cdd:cd16035 224 ALHVPLIISHP------------------------DLFGTGQTTDALTSHIDLLPTLLGLAGVDAE 265
|
|
| sulfatase_like |
cd16151 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
112-345 |
2.00e-15 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293770 [Multi-domain] Cd Length: 377 Bit Score: 77.25 E-value: 2.00e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 112 YPlenMTLAPDPHV--PDSLPpvaynpWMDIRERedvqalnisvpygpipvdfqRKIRQSYF-ASVSYLDTQVGHLLSAL 188
Cdd:cd16151 175 YP---MVLVHDPFVptPDSPD------WDPDDKR--------------------KKDDPEYFpDMVAYMDKLVGKLVDKL 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 189 DDLRLAHNTIIAFMSDHGWALGEHGEW-------AKYSNFDVTTRVPLMFYVPGKTAllpaageklfpyqdpfdpaselm 261
Cdd:cd16151 226 EELGLRENTIIIFTGDNGTHRPITSRTngrevrgGKGKTTDAGTHVPLIVNWPGLIP----------------------- 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 262 gAGRRTEDLVELVSLFPTLAGLAGMPVPPWCPIpsfhvelcrEGHNLqrYLQLH---DLEEDPYLFGNPRELiAYSQYPR 338
Cdd:cd16151 283 -AGGVSDDLVDFSDFLPTLAELAGAPLPEDYPL---------DGRSF--APQLLgktGSPRREWIYWYYRNP-HKKFGSR 349
|
....*..
gi 1958809850 339 PADFPQW 345
Cdd:cd16151 350 FVRTKRY 356
|
|
| sulfatase_like |
cd16156 |
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the ... |
72-290 |
2.80e-15 |
|
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293775 [Multi-domain] Cd Length: 468 Bit Score: 77.42 E-value: 2.80e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 72 TEEAIRLLEKMKTSvsPFFLAVGYHKPHIPFRYPKEFQKLYplENMTLAPDPHVPDSLP--PVAYNPWMDIREREDVQAL 149
Cdd:cd16156 161 TNRALDFIEKHKDE--DFFLVVSYDEPHHPFLCPKPYASMY--KDFEFPKGENAYDDLEnkPLHQRLWAGAKPHEDGDKG 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 150 NISVPYgpipvdfqrkirqsYFASVSYLDTQVGHLLSALDDLrlAHNTIIAFMSDHGWALGEHGEWAK-YSNFDVTTRVP 228
Cdd:cd16156 237 TIKHPL--------------YFGCNSFVDYEIGRVLDAADEI--AEDAWVIYTSDHGDMLGAHKLWAKgPAVYDEITNIP 300
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958809850 229 LMFYVPGKtallpaaGEKLFPYQDPfdpaselmgagrrtedlVELVSLFPTLAGLAGMPVPP 290
Cdd:cd16156 301 LIIRGKGG-------EKAGTVTDTP-----------------VSHIDLAPTILDYAGIPQPK 338
|
|
| sulfatase_like |
cd16152 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
72-419 |
5.14e-15 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293771 [Multi-domain] Cd Length: 373 Bit Score: 76.11 E-value: 5.14e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 72 TEEAIRLLEKmKTSVSPFFLAVGYHKPHIP---FRY--PKEFQKLYPlenmtlapDPHVPdslppvaynpwmdirerEDV 146
Cdd:cd16152 110 TDFAIDYLDN-RQKDKPFFLFLSYLEPHHQndrDRYvaPEGSAERFA--------NFWVP-----------------PDL 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 147 QALnisvpygpiPVDFQRKIrQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHgwalGEH-----GEWaKYSNF 221
Cdd:cd16152 164 AAL---------PGDWAEEL-PDYLGCCERLDENVGRIRDALKELGLYDNTIIVFTSDH----GCHfrtrnAEY-KRSCH 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 222 DVTTRVPLMFYVPGktallpaageklfpyqdpFDpaselmgAGRRTEDLVELVSLFPTLAGLAGMPVPpwcpiPSFHvel 301
Cdd:cd16152 229 ESSIRVPLVIYGPG------------------FN-------GGGRVEELVSLIDLPPTLLDAAGIDVP-----EEMQ--- 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 302 creGHNLQRYLQLHDleedpylfgNPRELIAYSQyprpadfpqwnsdkpslkdIK--VMGYSIRTIDYRYTVwvgFSPTE 379
Cdd:cd16152 276 ---GRSLLPLVDGKV---------EDWRNEVFIQ-------------------ISesQVGRAIRTDRWKYSV---AAPDK 321
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1958809850 380 --FLANFSDIHAGE-LYFVDSDPLQDHNVYNDSQHGGLLLSLR 419
Cdd:cd16152 322 dgWKDSGSDVYVEDyLYDLEADPYELVNLIGRPEYREVAAELR 364
|
|
| ARS_like |
cd16145 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
72-289 |
5.79e-15 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293764 [Multi-domain] Cd Length: 415 Bit Score: 76.09 E-value: 5.79e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 72 TEEAIRLLEKMKTSvsPFFLAVGYHKPHIPFRYPKefqklyplenmtLAPDPHVPDSLPPVAYNPWmdireredvqalni 151
Cdd:cd16145 175 TDEALDFIRENKDK--PFFLYLAYTLPHAPLQVPD------------DGPYKYKPKDPGIYAYLPW-------------- 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 152 svpygpipvdfqRKIRQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGwALGEHGEWAKYSNFDVT------- 224
Cdd:cd16145 227 ------------PQPEKAYAAMVTRLDRDVGRILALLKELGIDENTLVVFTSDNG-PHSEGGSEHDPDFFDSNgplrgyk 293
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958809850 225 -------TRVPLMFYVPGKTAllpaageklfpyqdpfdpaselmgAGRRTEDLVELVSLFPTLAGLAGMPVP 289
Cdd:cd16145 294 rslyeggIRVPFIARWPGKIP------------------------AGSVSDHPSAFWDFMPTLADLAGAEPP 341
|
|
| Sulfatase |
pfam00884 |
Sulfatase; |
68-286 |
1.29e-14 |
|
Sulfatase;
Pssm-ID: 459979 [Multi-domain] Cd Length: 298 Bit Score: 74.00 E-value: 1.29e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 68 DKQSTEEAIRLLEKMKTsvsPFFLAVGYHKPHIPFRYPKEFQKLYPlenmtlapdphvpdslppvaynpwmdireredvq 147
Cdd:pfam00884 144 DEALLDEALEFLDNNDK---PFFLVLHTLGSHGPPYYPDRYPEKYA---------------------------------- 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 148 alnISVPYGpipvDFQRKIRQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWALGEHGEWAKYSNFDVT--- 224
Cdd:pfam00884 187 ---TFKPSS----CSEEQLLNSYDNTLLYTDDAIGRVLDKLEENGLLDNTLVVYTSDHGESLGEGGGYLHGGKYDNApeg 259
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958809850 225 -TRVPLMFYVPGKTAllpaageklfpyqdpfdpaselmgAGRRTEDLVELVSLFPTLAGLAGM 286
Cdd:pfam00884 260 gYRVPLLIWSPGGKA------------------------KGQKSEALVSHVDLFPTILDLAGI 298
|
|
| GALNS_like |
cd16026 |
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ... |
72-289 |
2.71e-13 |
|
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
Pssm-ID: 293750 [Multi-domain] Cd Length: 399 Bit Score: 71.06 E-value: 2.71e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 72 TEEAIRLLEKMKTSvsPFFLAVGYHKPHIPFRYPKEFQKlyplenmtlapdphvpdslppvaynpwmdireredvqalni 151
Cdd:cd16026 170 TDEAVDFIERNKDQ--PFFLYLAHTMPHVPLFASEKFKG----------------------------------------- 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 152 svpygpipvdfqRKIRQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWALGEHGEW--------AKYSNFDV 223
Cdd:cd16026 207 ------------RSGAGLYGDVVEELDWSVGRILDALKELGLEENTLVIFTSDNGPWLEYGGHGgsagplrgGKGTTWEG 274
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958809850 224 TTRVPLMFYVPGKTAllpaageklfpyqdpfdpaselmgAGRRTEDLVELVSLFPTLAGLAGMPVP 289
Cdd:cd16026 275 GVRVPFIAWWPGVIP------------------------AGTVSDELASTMDLLPTLAALAGAPLP 316
|
|
| ARSK |
cd16171 |
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a ... |
164-290 |
3.65e-13 |
|
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a lysosomal sulfatase which exhibits an acidic pH optimum for catalytic activity against arylsulfate substrates. Other names for ARSK include arylsulfatase K and TSULF. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293781 [Multi-domain] Cd Length: 366 Bit Score: 70.26 E-value: 3.65e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 164 RKIRQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWALGEHGEWAKYSNFDVTTRVPLMFYVPGktallpaa 243
Cdd:cd16171 192 RNIRAFYYAMCAETDAMLGEIISALKDTGLLDKTYVFFTSDHGELAMEHRQFYKMSMYEGSSHVPLLIMGPG-------- 263
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1958809850 244 geklfpyqdpfdpaselMGAGRRTEDLVELVSLFPTLAGLAGMPVPP 290
Cdd:cd16171 264 -----------------IKAGQQVSDVVSLVDIYPTMLDIAGVPQPQ 293
|
|
| 4-S |
cd16029 |
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the ... |
72-294 |
1.05e-11 |
|
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the hydrolysis of sulfuric acid esters from a wide variety of substrates. N-acetylgalactosamine 4-sulfatase catalyzes the removal of the sulfate ester group from position 4 of an N-acetylgalactosamine sugar at the non-reducing terminus of the polysaccharide in the degradative pathways of the glycosaminoglycans dermatan sulfate and chondroitin-4-sulfate. N-acetylgalactosamine 4-sulfatase is a lysosomal enzyme.
Pssm-ID: 293753 [Multi-domain] Cd Length: 393 Bit Score: 66.03 E-value: 1.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 72 TEEAIRLLEKMKTSvSPFFLAVGYHKPHIPFRYPKEFQKLYPlenmtlAPDPHVPDslppvaynpwmdireredvqalni 151
Cdd:cd16029 168 TDRAVDIIENHDPS-KPLFLYLAFQAVHAPLQVPPEYADPYE------DKFAHIKD------------------------ 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 152 svpygpipvdfqrKIRQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGwALGEHGEWA--------KYSNFDV 223
Cdd:cd16029 217 -------------EDRRTYAAMVSALDESVGNVVDALKAKGMLDNTLIVFTSDNG-GPTGGGDGGsnyplrggKNTLWEG 282
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958809850 224 TTRVPLMFYVPgktaLLPAAgeklfpyqdpfdpaselmgAGRRTEDLVELVSLFPTLAGLAGMPVPPWCPI 294
Cdd:cd16029 283 GVRVPAFVWSP----LLPPK-------------------RGTVSDGLMHVTDWLPTLLSLAGGDPDDLPPL 330
|
|
| ARS_like |
cd16142 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
170-290 |
4.13e-11 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293761 [Multi-domain] Cd Length: 372 Bit Score: 64.09 E-value: 4.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 170 YFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHG-----WALGEHGEW--AKYSNFDVTTRVPLMFYVPGKTAllpa 242
Cdd:cd16142 182 YADSMVELDDHVGQILDALDELGIADNTIVIFTTDNGpeqdvWPDGGYTPFrgEKGTTWEGGVRVPAIVRWPGKIK---- 257
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1958809850 243 ageklfpyqdpfdpaselmgAGRRTEDLVELVSLFPTLAGLAGMPVPP 290
Cdd:cd16142 258 --------------------PGRVSNEIVSHLDWFPTLAALAGAPDPK 285
|
|
| ALP_like |
cd00016 |
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and ... |
167-284 |
5.43e-11 |
|
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and sulfatases. Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. Both alkaline phosphatase and sulfatase are essential for human metabolism. Deficiency of individual enzyme cause genetic diseases.
Pssm-ID: 293732 [Multi-domain] Cd Length: 237 Bit Score: 62.44 E-value: 5.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 167 RQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWALGEHGEWAKYS----NFDVTTRVPLMFYVPGktallpa 242
Cdd:cd00016 141 TPEYYDAVEEIDERIGKVLDALKKAGDADDTVIIVTADHGGIDKGHGGDPKADgkadKSHTGMRVPFIAYGPG------- 213
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1958809850 243 ageklfpyqdpfdpaselMGAGRRTEDLVELVSLFPTLAGLA 284
Cdd:cd00016 214 ------------------VKKGGVKHELISQYDIAPTLADLL 237
|
|
| ARS_like |
cd16143 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
72-289 |
1.85e-10 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293762 [Multi-domain] Cd Length: 395 Bit Score: 62.22 E-value: 1.85e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 72 TEEAIRLLEKMKTSVSPFFLAVGYHKPHIPFRYPKEFQKLYpleNMTlapdphvpdslppvaynpwmdireredvqalni 151
Cdd:cd16143 158 TDKAVEFIDQHAKKDKPFFLYFALPAPHTPIVPSPEFQGKS---GAG--------------------------------- 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 152 svPYGpipvDFqrkIRQsyfasvsyLDTQVGHLLSALDDLRLAHNTIIAFMSDHG-------WALGEHGEWA-------K 217
Cdd:cd16143 202 --PYG----DF---VYE--------LDWVVGRILDALKELGLAENTLVIFTSDNGpspyadyKELEKFGHDPsgplrgmK 264
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958809850 218 YSNFDVTTRVPLMFYVPGKTallpaageklfpyqdpfdpaselmGAGRRTEDLVELVSLFPTLAGLAGMPVP 289
Cdd:cd16143 265 ADIYEGGHRVPFIVRWPGKI------------------------PAGSVSDQLVSLTDLFATLAAIVGQKLP 312
|
|
| YejM |
COG3083 |
Periplasmic protein PbgA/YejM, regulator of the LPS biosynthesis, AlkP superfamily [Cell wall ... |
68-238 |
2.34e-10 |
|
Periplasmic protein PbgA/YejM, regulator of the LPS biosynthesis, AlkP superfamily [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];
Pssm-ID: 442317 [Multi-domain] Cd Length: 603 Bit Score: 62.23 E-value: 2.34e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 68 DKQSTEEAIRLLEKMKTSvSPFFLAVGYHKPHIPFRYPKEFQKLYPLENMTLAPDPHVPDSLPpvaynpwmdireredvq 147
Cdd:COG3083 363 DRQITAQWLQWLDQRDSD-RPWFSYLFLDAPHAYSFPADYPKPFQPSEDCNYLALDNESDPTP----------------- 424
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 148 alnisvpygpipvdfqrkIRQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWALGEHGE--WAKYSNF-DVT 224
Cdd:COG3083 425 ------------------FKNRYRNAVHYVDSQIGRVLDTLEQRGLLENTIVIITADHGEEFNENGQnyWGHNSNFsRYQ 486
|
170
....*....|....
gi 1958809850 225 TRVPLMFYVPGKTA 238
Cdd:COG3083 487 LQVPLVIHWPGTPP 500
|
|
| PAS_like |
cd16025 |
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze ... |
72-220 |
1.28e-09 |
|
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293749 [Multi-domain] Cd Length: 402 Bit Score: 59.76 E-value: 1.28e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 72 TEEAIRLLEKMKTSVSPFFLAVGYHKPHIPFRYPKEF----------------------QK---LYPlENMTLAPDPH-V 125
Cdd:cd16025 122 TDKAIEYIDEQKAPDKPFFLYLAFGAPHAPLQAPKEWidkykgkydagwdalreerlerQKelgLIP-ADTKLTPRPPgV 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 126 P--DSLPPvaynpwmdirEREDVQALNISVpygpipvdfqrkirqsYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMS 203
Cdd:cd16025 201 PawDSLSP----------EEKKLEARRMEV----------------YAAMVEHMDQQIGRLIDYLKELGELDNTLIIFLS 254
|
170
....*....|....*..
gi 1958809850 204 DHGwALGEHGeWAKYSN 220
Cdd:cd16025 255 DNG-ASAEPG-WANASN 269
|
|
| MdoB |
COG1368 |
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope ... |
66-291 |
1.81e-08 |
|
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440979 [Multi-domain] Cd Length: 576 Bit Score: 56.20 E-value: 1.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 66 LPDKQSTEEAIRLLEKMKtsvSPFFLAV----GyhkpHIPFRYPKEFQKLYPLENMTLapdphvpdslppvaynpwmdir 141
Cdd:COG1368 366 VSDEDLFDKALEELEKLK---KPFFAFLitlsN----HGPYTLPEEDKKIPDYGKTTL---------------------- 416
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 142 eredvqalnisvpygpipvdfqrkirQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDH-GWALGEHGEWAKYSN 220
Cdd:COG1368 417 --------------------------NNYLNAVRYADQALGEFIEKLKKSGWYDNTIFVIYGDHgPRSPGKTDYENPLER 470
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958809850 221 FdvttRVPLMFYVPGktallpaageklfpyqdpfdpaselMGAGRRTEDLVELVSLFPTLAGLAGMPVPPW 291
Cdd:COG1368 471 Y----RVPLLIYSPG-------------------------LKKPKVIDTVGSQIDIAPTLLDLLGIDYPSY 512
|
|
| ES |
cd16159 |
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of ... |
170-289 |
5.05e-08 |
|
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of the active estrogen in tumor cells. ES catalyzes the hydrolysis of E1 sulfate, which is a component of the three-enzyme system that has been implicated in intracrine biosynthesis of estradiol. It is associated with the membrane of the endoplasmic reticulum (ER). The structure of ES consisting of two antiparallel alpha helices that protrude from the roughly spherical molecule. These highly hydrophobic helices anchor the functional domain on the membrane surface facing the ER lumen.
Pssm-ID: 293778 [Multi-domain] Cd Length: 521 Bit Score: 54.99 E-value: 5.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 170 YFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWAL------GEHGEW-------AKYSNFDVTTRVPLMFYVPGK 236
Cdd:cd16159 281 YGDNVEEMDWSVGQILDALDELGLKDNTFVYFTSDNGGHLeeisvgGEYGGGnggiyggKKMGGWEGGIRVPTIVRWPGV 360
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1958809850 237 talLPAAGEklfpyqdpFDPASELMgagrrtedlvelvSLFPTLAGLAGMPVP 289
Cdd:cd16159 361 ---IPPGSV--------IDEPTSLM-------------DIFPTVAALAGAPLP 389
|
|
| LTA_synthase |
cd16015 |
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer ... |
157-285 |
5.22e-08 |
|
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer found in Gram-positive bacteria. It may contain long chains of ribitol or glycerol phosphate. LTA synthase catalyzes the reaction to extend the polymer by the repeated addition of glycerolphosphate (GroP) subunits to the end of the growing chain.
Pssm-ID: 293739 [Multi-domain] Cd Length: 283 Bit Score: 53.84 E-value: 5.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 157 PIPVDFQRKIRQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWALGEHGEWAKYSNFDVtTRVPLMFYVPGK 236
Cdd:cd16015 181 PLKVEEDKTELENYLNAIHYTDKALGEFIEKLKKSGLYENTIIVIYGDHLPSLGSDYDETDEDPLDL-YRTPLLIYSPGL 259
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1958809850 237 TallpaageklfpyqdpfdpaselmgAGRRTEDLVELVSLFPTLAGLAG 285
Cdd:cd16015 260 K-------------------------KPKKIDRVGSQIDIAPTLLDLLG 283
|
|
| spARS_like |
cd16160 |
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its ... |
167-289 |
3.59e-06 |
|
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its homologous proteins. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293779 [Multi-domain] Cd Length: 445 Bit Score: 48.97 E-value: 3.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 167 RQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWAL---GEHGEWA-----KYSNFDVTTRVPLMFYVPGKTa 238
Cdd:cd16160 221 RGRYGDNINEMSWAVGEVLDTLVDTGLDQNTLVFFLSDHGPHVeycLEGGSTGglkggKGNSWEGGIRVPFIAYWPGTI- 299
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1958809850 239 llpaageklfpyqdpfdpaselmgAGRRTEDLVELVSLFPTLAGLAGMPVP 289
Cdd:cd16160 300 ------------------------KPRVSHEVVSTMDIFPTFVDLAGGTLP 326
|
|
| ARSG |
cd16161 |
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze ... |
166-290 |
1.06e-05 |
|
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze sulfate esters in a wide variety of substrates such as glycosaminoglycans, steroid sulfates, or sulfolipids. ARSG has arylsulfatase activity toward different pseudosubstrates like p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. An active site Cys is post-translationally converted to the critical active site C(alpha)-formylglycine. ARSG mRNA expression was found to be tissue-specific with highest expression in liver, kidney, and pancreas, suggesting a metabolic role of ARSG that might be associated with a non-classified lysosomal storage disorder.
Pssm-ID: 293780 [Multi-domain] Cd Length: 383 Bit Score: 47.46 E-value: 1.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 166 IRQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHG-WALG-------EHGEW--------AKYSNFDVTTRVPL 229
Cdd:cd16161 181 GRGPYGDALQEMDDLVGQIMDAVKHAGLKDNTLTWFTSDNGpWEVKcelavgpGTGDWqgnlggsvAKASTWEGGHREPA 260
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958809850 230 MFYVPGKTAllpaageklfpyqdpfdpaselmgAGRRTEDLVELVSLFPTLAGLAGMPVPP 290
Cdd:cd16161 261 IVYWPGRIP------------------------ANSTSAALVSTLDIFPTVVALAGASLPP 297
|
|
| GALNS |
cd16157 |
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ... |
167-289 |
8.67e-05 |
|
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
Pssm-ID: 293776 [Multi-domain] Cd Length: 466 Bit Score: 44.77 E-value: 8.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 167 RQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWAL-------GEHGEW--AKYSNFDVTTRVPLMFYVPGKT 237
Cdd:cd16157 223 RGLYGDAVMELDSSVGKILESLKSLGIENNTFVFFSSDNGAALisapeqgGSNGPFlcGKQTTFEGGMREPAIAWWPGHI 302
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1958809850 238 AllpaageklfpyqdpfdpaselmgAGRRTEDLVELVSLFPTLAGLAGMPVP 289
Cdd:cd16157 303 K------------------------PGQVSHQLGSLMDLFTTSLALAGLPIP 330
|
|
| Enpp |
cd16018 |
Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin; Ecto-nucleotide ... |
172-235 |
1.21e-04 |
|
Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin; Ecto-nucleotide pyrophosphatases/phosphodiesterases (ENPPs) hydrolyze 5'-phosphodiester bonds in nucleotides and their derivatives, resulting in the release of 5'-nucleotide monophosphates. ENPPs have multiple physiological roles, including nucleotide recycling, modulation of purinergic receptor signaling, regulation of extracellular pyrophosphate levels, stimulation of cell motility, and possible roles in regulation of insulin receptor (IR) signaling and activity of ecto-kinases. The eukaryotic ENPP family contains at least five members that have different tissue distribution and physiological roles.
Pssm-ID: 293742 [Multi-domain] Cd Length: 267 Bit Score: 43.34 E-value: 1.21e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958809850 172 ASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWA-LGEHGewakYSNFDVTTRVPLMFYVPG 235
Cdd:cd16018 183 EALKRVDRRLGYLIEALKERGLLDDTNIIVVSDHGMTdVGTHG----YDNELPDMRAIFIARGPA 243
|
|
| LptA |
cd16017 |
Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine ... |
99-286 |
3.56e-04 |
|
Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine Transferase; Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine Transferase catalyzes the modification of the lipid A headgroups by phosphoethanolamine (PEA) or 4-amino-arabinose residues. Lipopolysaccharides, also called endotoxins, protect bacterial pathogens from antimicrobial peptides and have roles in virulence. The PEA modified lipid A increases resistance to the cationic cyclic polypeptide antibiotic, polymyxin. Lipid A PEA transferases usually consist of a transmembrane domain anchoring the enzyme to the periplasmic face of the cytoplasmic membrane.
Pssm-ID: 293741 [Multi-domain] Cd Length: 288 Bit Score: 42.23 E-value: 3.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 99 HIPF--RYPKEFQKLYPlenmtlapdphvpdslppvaynpwmdireredvqalnisVPYGPIPVDFQRKIRQSYFASVSY 176
Cdd:cd16017 154 HGPYydRYPEEFAKFTP---------------------------------------DCDNELQSCSKEELINAYDNSILY 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 177 LDTQVGHLLSALDdlRLAHNTIIAFMSDHGWALGEHGEW--AKYSNFDVTTRVPLMFYVPGKTALLPAAGEKLFPYQDPF 254
Cdd:cd16017 195 TDYVLSQIIERLK--KKDKDAALIYFSDHGESLGENGLYlhGAPYAPKEQYHVPFIIWSSDSYKQRYPVERLRANKDRPF 272
|
170 180 190
....*....|....*....|....*....|..
gi 1958809850 255 dpaselmgagrRTEDlvelvsLFPTLAGLAGM 286
Cdd:cd16017 273 -----------SHDN------LFHTLLGLLGI 287
|
|
| ARSA |
cd16158 |
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely ... |
164-289 |
8.27e-04 |
|
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. It is a member of the sulfatase family. The arylsulfatase A was located in lysosome-like structures and transported to dense lysosomes in a mannose 6-phosphate receptor-dependent manner. Deficiency of arylsulfatase A leads to the accumulation of cerebroside sulfate, which causes a lethal progressive demyelination. Arylsulfatase A requires the posttranslational oxidation of the -CH2SH group of a conserved cysteine to an aldehyde, yielding a formylglycine to be in an active form.
Pssm-ID: 293777 [Multi-domain] Cd Length: 479 Bit Score: 41.66 E-value: 8.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809850 164 RKIRQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWAL------GEHG--EWAKYSNFDVTTRVPLMFYVPG 235
Cdd:cd16158 222 RSSRGPFGDALAELDGSVGELLQTLKENGIDNNTLVFFTSDNGPSTmrksrgGNAGllKCGKGTTYEGGVREPAIAYWPG 301
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1958809850 236 KtallpaageklfpyqdpFDPAselmgagrRTEDLVELVSLFPTLAGLAGMPVP 289
Cdd:cd16158 302 R-----------------IKPG--------VTHELASTLDILPTIAKLAGAPLP 330
|
|
| OpgE |
COG2194 |
Phosphoethanolamine transferase for periplasmic glucans OpgE, AlkP superfamily [Cell wall ... |
163-213 |
8.20e-03 |
|
Phosphoethanolamine transferase for periplasmic glucans OpgE, AlkP superfamily [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441797 [Multi-domain] Cd Length: 537 Bit Score: 38.30 E-value: 8.20e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1958809850 163 QRKIRQSYFASVSYLDTQVGHLLSALDDLRLAHNTIIAFMSDHGWALGEHG 213
Cdd:COG2194 407 REELVNAYDNTILYTDYVLSQVIDLLKAKQDRYDTAMLYVSDHGESLGENG 457
|
|
| |
