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Conserved domains on  [gi|1958809777|ref|XP_038956458|]
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zinc finger protein 280C isoform X4 [Rattus norvegicus]

Protein Classification

zinc finger protein 280A/B/C/D( domain architecture ID 10619755)

zinc finger protein 280A/B/C/D may function as a transcription factor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4195 pfam13836
Domain of unknown function (DUF4195); This family is found at the N-terminus of metazoan ...
 62-205 2.75e-47

Domain of unknown function (DUF4195); This family is found at the N-terminus of metazoan proteins that carry PHD-like zinc-finger domains. The function is not known.


:

Pssm-ID: 463993 [Multi-domain]  Cd Length: 184  Bit Score: 165.31  E-value: 2.75e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809777  62 IFVGEISSSKPAISNILNRCSPGSSSKGLKNGSFSPALSNIFKPTNQHYRNPPSHPLIALP-SFYPAPKSSESSD-VQTV 139
Cdd:pfam13836   1 IFVGEISSSKPAISNILNRVNPGSSSRRIKNGHLSPGIAHIFKPTSQHYVTPTSNPVAALPvSFHPESRSSDSSViVQPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809777 140 SKPTFLKTSPQDDSGASSASLLDSTKD-IPSSNVLQKSTGRG------------------------------------SA 182
Cdd:pfam13836  81 SKPDYKKNSPQVVSDNSSDLLFDLTQDtVPQSQVGPALSVEGmnessfvskrpstsevnsvnpkkpklsegisgtnssAS 160

                         170       180
                  ....*....|....*....|....
gi 1958809777 183 SSLNMSPSEASSQVVLSN-MNTSS 205
Cdd:pfam13836 161 SPSIKSPSVTSSQVTPSKgTNTSS 184
 
Name Accession Description Interval E-value
DUF4195 pfam13836
Domain of unknown function (DUF4195); This family is found at the N-terminus of metazoan ...
 62-205 2.75e-47

Domain of unknown function (DUF4195); This family is found at the N-terminus of metazoan proteins that carry PHD-like zinc-finger domains. The function is not known.


Pssm-ID: 463993 [Multi-domain]  Cd Length: 184  Bit Score: 165.31  E-value: 2.75e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809777  62 IFVGEISSSKPAISNILNRCSPGSSSKGLKNGSFSPALSNIFKPTNQHYRNPPSHPLIALP-SFYPAPKSSESSD-VQTV 139
Cdd:pfam13836   1 IFVGEISSSKPAISNILNRVNPGSSSRRIKNGHLSPGIAHIFKPTSQHYVTPTSNPVAALPvSFHPESRSSDSSViVQPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809777 140 SKPTFLKTSPQDDSGASSASLLDSTKD-IPSSNVLQKSTGRG------------------------------------SA 182
Cdd:pfam13836  81 SKPDYKKNSPQVVSDNSSDLLFDLTQDtVPQSQVGPALSVEGmnessfvskrpstsevnsvnpkkpklsegisgtnssAS 160

                         170       180
                  ....*....|....*....|....
gi 1958809777 183 SSLNMSPSEASSQVVLSN-MNTSS 205
Cdd:pfam13836 161 SPSIKSPSVTSSQVTPSKgTNTSS 184
KREPA2 cd23959
Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of ...
 111-236 3.24e-05

Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of the parasitic protozoan's KREPA RNA editing catalytic complex (RECC). Kinetoplastid RNA editing (KRE) proteins occur as pairs or sets of related proteins in multiple complexes. KREPA complex is composed of six components (KREPA1-6), which share a conserved C-terminal region containing an oligonucleotide-binding (OB)-fold-like domain. KREPAs are responsible for the site-specific insertion and deletion of U nucleotides in the kinetoplastid mitochondria pre-messenger RNA. Apart from the conserved C-terminal OB-fold domain, KREPA1, KREPA2, and KREPA3 contain two conserved C2H2 zinc-finger domains. KREPA2 and kinetoplastid RNA editing ligase 1 (KREL1) are specific for ligation post-U-deletion and are paralogous to KREL2 and KREPA1 that are specific for ligation post-U-insertion. KREPA2, is critical for RECC stability and KREL1 integration into the complex.


Pssm-ID: 467780 [Multi-domain]  Cd Length: 424  Bit Score: 46.79  E-value: 3.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809777 111 RNPPSHPLIALPSFY----PAPKSSESSDVQTVSKPTFLKTSPQDDSGASSASLLDSTKDIPSSNVLQKSTGRGSASSLN 186
Cdd:cd23959   143 QTAPVTPFGQLPMFGqhppPAKPLPAAAAAQQSSASPGEVASPFASGTVSASPFATATDTAPSSGAPDGFPAEASAPSPF 222

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958809777 187 MSPSEASSqvvlsnMNTSSIQSAAGKPSLRSCPKCNVKFSLLDPLKCHMK 236
Cdd:cd23959   223 AAPASAAS------FPAAPVANGEAATPTHACTICGKAFSTHEGLRMHSK 266
 
Name Accession Description Interval E-value
DUF4195 pfam13836
Domain of unknown function (DUF4195); This family is found at the N-terminus of metazoan ...
 62-205 2.75e-47

Domain of unknown function (DUF4195); This family is found at the N-terminus of metazoan proteins that carry PHD-like zinc-finger domains. The function is not known.


Pssm-ID: 463993 [Multi-domain]  Cd Length: 184  Bit Score: 165.31  E-value: 2.75e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809777  62 IFVGEISSSKPAISNILNRCSPGSSSKGLKNGSFSPALSNIFKPTNQHYRNPPSHPLIALP-SFYPAPKSSESSD-VQTV 139
Cdd:pfam13836   1 IFVGEISSSKPAISNILNRVNPGSSSRRIKNGHLSPGIAHIFKPTSQHYVTPTSNPVAALPvSFHPESRSSDSSViVQPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809777 140 SKPTFLKTSPQDDSGASSASLLDSTKD-IPSSNVLQKSTGRG------------------------------------SA 182
Cdd:pfam13836  81 SKPDYKKNSPQVVSDNSSDLLFDLTQDtVPQSQVGPALSVEGmnessfvskrpstsevnsvnpkkpklsegisgtnssAS 160

                         170       180
                  ....*....|....*....|....
gi 1958809777 183 SSLNMSPSEASSQVVLSN-MNTSS 205
Cdd:pfam13836 161 SPSIKSPSVTSSQVTPSKgTNTSS 184
KREPA2 cd23959
Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of ...
 111-236 3.24e-05

Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of the parasitic protozoan's KREPA RNA editing catalytic complex (RECC). Kinetoplastid RNA editing (KRE) proteins occur as pairs or sets of related proteins in multiple complexes. KREPA complex is composed of six components (KREPA1-6), which share a conserved C-terminal region containing an oligonucleotide-binding (OB)-fold-like domain. KREPAs are responsible for the site-specific insertion and deletion of U nucleotides in the kinetoplastid mitochondria pre-messenger RNA. Apart from the conserved C-terminal OB-fold domain, KREPA1, KREPA2, and KREPA3 contain two conserved C2H2 zinc-finger domains. KREPA2 and kinetoplastid RNA editing ligase 1 (KREL1) are specific for ligation post-U-deletion and are paralogous to KREL2 and KREPA1 that are specific for ligation post-U-insertion. KREPA2, is critical for RECC stability and KREL1 integration into the complex.


Pssm-ID: 467780 [Multi-domain]  Cd Length: 424  Bit Score: 46.79  E-value: 3.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958809777 111 RNPPSHPLIALPSFY----PAPKSSESSDVQTVSKPTFLKTSPQDDSGASSASLLDSTKDIPSSNVLQKSTGRGSASSLN 186
Cdd:cd23959   143 QTAPVTPFGQLPMFGqhppPAKPLPAAAAAQQSSASPGEVASPFASGTVSASPFATATDTAPSSGAPDGFPAEASAPSPF 222

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958809777 187 MSPSEASSqvvlsnMNTSSIQSAAGKPSLRSCPKCNVKFSLLDPLKCHMK 236
Cdd:cd23959   223 AAPASAAS------FPAAPVANGEAATPTHACTICGKAFSTHEGLRMHSK 266
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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