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Conserved domains on  [gi|1958808254|ref|XP_038955997|]
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cleavage stimulation factor subunit 2 isoform X7 [Rattus norvegicus]

Protein Classification

CSTF2_hinge and CSTF_C domain-containing protein( domain architecture ID 10626797)

CSTF2_hinge and CSTF_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CSTF2_hinge pfam14327
Hinge domain of cleavage stimulation factor subunit 2; The hinge domain of cleavage ...
 1-52 9.53e-20

Hinge domain of cleavage stimulation factor subunit 2; The hinge domain of cleavage stimulation factor subunit 2 proteins, CSTF2, is necessary for binding to the subunit CstF-77 within the polyadenylation complex and subsequent nuclear localization. This suggests that nuclear import of a pre-formed CSTF complex is an essential step in polyadenylation. Accurate and efficient polyadenylation is essential for transcriptional termination, nuclear export, translation, and stability of eukaryotic mRNAs. CSTF2 is an important regulatory subunit of the polyadenylation complex.


:

Pssm-ID: 433869 [Multi-domain]  Cd Length: 81  Bit Score: 83.36  E-value: 9.53e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958808254   1 MFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMRIVDPEIALKIL 52
Cdd:pfam14327  30 LLELLSQMKALAQNNPAQARELLIQNPQLAYALFQALLLMGLVDPDVITSVL 81
CSTF_C pfam14304
Transcription termination and cleavage factor C-terminal; The C-terminal section of CSTF ...
 441-481 2.02e-11

Transcription termination and cleavage factor C-terminal; The C-terminal section of CSTF proteins is a discreet structure is crucial for mRNA 3'-end processing. This domain interacts with Pcf11 and possibly PC4, thus linking CstF2 to transcription, transcriptional termination, and cell growth.


:

Pssm-ID: 464130  Cd Length: 41  Bit Score: 58.50  E-value: 2.02e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1958808254 441 QDHEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKS 481
Cdd:pfam14304   1 QDPGQAELIQQVLQLSEAQIAALPPDQRRSIMELRQQLRRG 41
 
Name Accession Description Interval E-value
CSTF2_hinge pfam14327
Hinge domain of cleavage stimulation factor subunit 2; The hinge domain of cleavage ...
 1-52 9.53e-20

Hinge domain of cleavage stimulation factor subunit 2; The hinge domain of cleavage stimulation factor subunit 2 proteins, CSTF2, is necessary for binding to the subunit CstF-77 within the polyadenylation complex and subsequent nuclear localization. This suggests that nuclear import of a pre-formed CSTF complex is an essential step in polyadenylation. Accurate and efficient polyadenylation is essential for transcriptional termination, nuclear export, translation, and stability of eukaryotic mRNAs. CSTF2 is an important regulatory subunit of the polyadenylation complex.


Pssm-ID: 433869 [Multi-domain]  Cd Length: 81  Bit Score: 83.36  E-value: 9.53e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958808254   1 MFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMRIVDPEIALKIL 52
Cdd:pfam14327  30 LLELLSQMKALAQNNPAQARELLIQNPQLAYALFQALLLMGLVDPDVITSVL 81
CSTF_C pfam14304
Transcription termination and cleavage factor C-terminal; The C-terminal section of CSTF ...
 441-481 2.02e-11

Transcription termination and cleavage factor C-terminal; The C-terminal section of CSTF proteins is a discreet structure is crucial for mRNA 3'-end processing. This domain interacts with Pcf11 and possibly PC4, thus linking CstF2 to transcription, transcriptional termination, and cell growth.


Pssm-ID: 464130  Cd Length: 41  Bit Score: 58.50  E-value: 2.02e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1958808254 441 QDHEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKS 481
Cdd:pfam14304   1 QDPGQAELIQQVLQLSEAQIAALPPDQRRSIMELRQQLRRG 41
 
Name Accession Description Interval E-value
CSTF2_hinge pfam14327
Hinge domain of cleavage stimulation factor subunit 2; The hinge domain of cleavage ...
 1-52 9.53e-20

Hinge domain of cleavage stimulation factor subunit 2; The hinge domain of cleavage stimulation factor subunit 2 proteins, CSTF2, is necessary for binding to the subunit CstF-77 within the polyadenylation complex and subsequent nuclear localization. This suggests that nuclear import of a pre-formed CSTF complex is an essential step in polyadenylation. Accurate and efficient polyadenylation is essential for transcriptional termination, nuclear export, translation, and stability of eukaryotic mRNAs. CSTF2 is an important regulatory subunit of the polyadenylation complex.


Pssm-ID: 433869 [Multi-domain]  Cd Length: 81  Bit Score: 83.36  E-value: 9.53e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958808254   1 MFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMRIVDPEIALKIL 52
Cdd:pfam14327  30 LLELLSQMKALAQNNPAQARELLIQNPQLAYALFQALLLMGLVDPDVITSVL 81
CSTF_C pfam14304
Transcription termination and cleavage factor C-terminal; The C-terminal section of CSTF ...
 441-481 2.02e-11

Transcription termination and cleavage factor C-terminal; The C-terminal section of CSTF proteins is a discreet structure is crucial for mRNA 3'-end processing. This domain interacts with Pcf11 and possibly PC4, thus linking CstF2 to transcription, transcriptional termination, and cell growth.


Pssm-ID: 464130  Cd Length: 41  Bit Score: 58.50  E-value: 2.02e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1958808254 441 QDHEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKS 481
Cdd:pfam14304   1 QDPGQAELIQQVLQLSEAQIAALPPDQRRSIMELRQQLRRG 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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