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Conserved domains on  [gi|1958642382|ref|XP_038955903|]
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ADP-ribose glycohydrolase MACROD1 isoform X6 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Macro_SF super family cl00019
macrodomain superfamily; Macrodomains are found in a variety of proteins with diverse cellular ...
 151-170 2.44e-08

macrodomain superfamily; Macrodomains are found in a variety of proteins with diverse cellular functions, as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Macrodomains can recognize ADP-ribose (ADPr) in both its free and protein-linked forms, in related ligands, such as O-acyl-ADP-ribose (OAADPr), and even in ligands unrelated to ADPr. Macrodomains include the yeast macrodomain Poa1 which is a phosphatase of ADP-ribose-1"-phosphate, a by-product of tRNA splicing. Some macrodomains have ADPr-unrelated binding partners such as the coronavirus SUD-N (N-terminal subdomain) and SUD-M (middle subdomain) of the SARS-unique domain (SUD) which bind G-quadruplexes (unusual nucleic-acid structures formed by consecutive guanosine nucleotides). Macrodomains regulate a wide variety of cellular and organismal processes, including DNA damage repair, signal transduction, and immune response.


The actual alignment was detected with superfamily member cd02908:

Pssm-ID: 469581  Cd Length: 166  Bit Score: 50.59  E-value: 2.44e-08
                          10        20
                  ....*....|....*....|
gi 1958642382 151 KISLFRGDITKLEVDAIVNA 170
Cdd:cd02908     1 KISLWRGDITKLEVDAIVNA 20
 
Name Accession Description Interval E-value
Macro_OAADPr_deacetylase cd02908
macrodomain, O-acetyl-ADP-ribose (OAADPr) family; Macrodomains are found in a variety of ...
 151-170 2.44e-08

macrodomain, O-acetyl-ADP-ribose (OAADPr) family; Macrodomains are found in a variety of proteins with diverse cellular functions, as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Macrodomains can recognize ADP-ribose (ADPr) in both its free and protein-linked forms, in related ligands, such as O-acyl-ADP-ribose (OAADPr), and even in ligands unrelated to ADPr. This family includes eukaryotic macrodomain proteins such as human MacroD1 and MacroD2, and bacterial proteins such as Escherichia coli YmdB; these have been shown to be O-acetyl-ADP-ribose (OAADPr) deacetylases that efficiently catalyze the hydrolysis of OAADPr to produce ADP-ribose and free acetate. OAADPr is a sirtuin reaction product generated from the NAD+-dependent protein deacetylation reactions and has been implicated as a signaling molecule. By acting on mono-ADP-ribosylated substrates, OAADPr deacetylases may reverse cellular ADP-ribosylation.


Pssm-ID: 438955  Cd Length: 166  Bit Score: 50.59  E-value: 2.44e-08
                          10        20
                  ....*....|....*....|
gi 1958642382 151 KISLFRGDITKLEVDAIVNA 170
Cdd:cd02908     1 KISLWRGDITKLEVDAIVNA 20
PRK00431 PRK00431
ADP-ribose-binding protein;
151-170 2.06e-05

ADP-ribose-binding protein;


Pssm-ID: 234759  Cd Length: 177  Bit Score: 42.52  E-value: 2.06e-05
                          10        20
                  ....*....|....*....|
gi 1958642382 151 KISLFRGDITKLEVDAIVNA 170
Cdd:PRK00431    4 RIEVVQGDITELEVDAIVNA 23
YmdB COG2110
O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ...
 152-170 4.25e-05

O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441713  Cd Length: 168  Bit Score: 41.70  E-value: 4.25e-05
                          10
                  ....*....|....*....
gi 1958642382 152 ISLFRGDITKLEVDAIVNA 170
Cdd:COG2110     1 IEIVQGDITELDVDAIVNA 19
A1pp smart00506
Appr-1"-p processing enzyme; Function determined by Martzen et al. Extended family detected by ...
 151-170 2.88e-03

Appr-1"-p processing enzyme; Function determined by Martzen et al. Extended family detected by reciprocal PSI-BLAST searches (unpublished results, and Pehrson _ Fuji).


Pssm-ID: 214701  Cd Length: 133  Bit Score: 36.13  E-value: 2.88e-03
                           10        20
                   ....*....|....*....|
gi 1958642382  151 KISLFRGDITKLEVDAIVNA 170
Cdd:smart00506   1 ILKVVKGDITKPRADAIVNA 20
 
Name Accession Description Interval E-value
Macro_OAADPr_deacetylase cd02908
macrodomain, O-acetyl-ADP-ribose (OAADPr) family; Macrodomains are found in a variety of ...
 151-170 2.44e-08

macrodomain, O-acetyl-ADP-ribose (OAADPr) family; Macrodomains are found in a variety of proteins with diverse cellular functions, as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Macrodomains can recognize ADP-ribose (ADPr) in both its free and protein-linked forms, in related ligands, such as O-acyl-ADP-ribose (OAADPr), and even in ligands unrelated to ADPr. This family includes eukaryotic macrodomain proteins such as human MacroD1 and MacroD2, and bacterial proteins such as Escherichia coli YmdB; these have been shown to be O-acetyl-ADP-ribose (OAADPr) deacetylases that efficiently catalyze the hydrolysis of OAADPr to produce ADP-ribose and free acetate. OAADPr is a sirtuin reaction product generated from the NAD+-dependent protein deacetylation reactions and has been implicated as a signaling molecule. By acting on mono-ADP-ribosylated substrates, OAADPr deacetylases may reverse cellular ADP-ribosylation.


Pssm-ID: 438955  Cd Length: 166  Bit Score: 50.59  E-value: 2.44e-08
                          10        20
                  ....*....|....*....|
gi 1958642382 151 KISLFRGDITKLEVDAIVNA 170
Cdd:cd02908     1 KISLWRGDITKLEVDAIVNA 20
Macro_Af1521_BAL-like cd02907
macrodomain, Af1521-like family; Macrodomains are found in a variety of proteins with diverse ...
 151-170 1.44e-05

macrodomain, Af1521-like family; Macrodomains are found in a variety of proteins with diverse cellular functions, as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Macrodomains can recognize ADP-ribose (ADPr) in both its free and protein-linked forms, in related ligands, such as O-acyl-ADP-ribose (OAADPr), and even in ligands unrelated to ADPr. The macrodomains in this family show similarity to Af1521, a protein from Archaeoglobus fulgidus containing a stand-alone macrodomain. Af1521 binds ADP-ribose and exhibits phosphatase activity toward ADP-ribose-1"-monophosphate (Appr-1"-p). Also included in this family are the N-terminal (or first) macrodomains of BAL (B-aggressive lymphoma) proteins which contain multiple macrodomains, such as the first macrodomain of mono-ADP-ribosyltransferase PARP14 (PARP-14, also known as ADP-ribosyltransferase diphtheria toxin-like 8, ATRD8, B aggressive lymphoma protein 2, or BAL2). Most BAL proteins also contain a C-terminal PARP active site and are also named as PARPs. Human BAL1 (or PARP-9) was originally identified as a risk-related gene in diffuse large B-cell lymphoma that promotes malignant B-cell migration. Some BAL family proteins exhibit PARP activity. Poly (ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins. BAL proteins may also function as transcriptional repressors.


Pssm-ID: 394877 [Multi-domain]  Cd Length: 158  Bit Score: 42.86  E-value: 1.44e-05
                          10        20
                  ....*....|....*....|
gi 1958642382 151 KISLFRGDITKLEVDAIVNA 170
Cdd:cd02907     3 KVSVYKGDITKEKVDAIVNA 22
PRK00431 PRK00431
ADP-ribose-binding protein;
151-170 2.06e-05

ADP-ribose-binding protein;


Pssm-ID: 234759  Cd Length: 177  Bit Score: 42.52  E-value: 2.06e-05
                          10        20
                  ....*....|....*....|
gi 1958642382 151 KISLFRGDITKLEVDAIVNA 170
Cdd:PRK00431    4 RIEVVQGDITELEVDAIVNA 23
PRK04143 PRK04143
protein-ADP-ribose hydrolase;
149-170 2.80e-05

protein-ADP-ribose hydrolase;


Pssm-ID: 235225  Cd Length: 264  Bit Score: 43.05  E-value: 2.80e-05
                          10        20
                  ....*....|....*....|..
gi 1958642382 149 NEKISLFRGDITKLEVDAIVNA 170
Cdd:PRK04143   82 YDNIFLWQGDITRLKVDAIVNA 103
YmdB COG2110
O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ...
 152-170 4.25e-05

O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441713  Cd Length: 168  Bit Score: 41.70  E-value: 4.25e-05
                          10
                  ....*....|....*....
gi 1958642382 152 ISLFRGDITKLEVDAIVNA 170
Cdd:COG2110     1 IEIVQGDITELDVDAIVNA 19
Macro_GDAP2-like cd02905
macrodomain, GDAP2-like family; Macrodomains are found in a variety of proteins with diverse ...
 151-170 1.20e-03

macrodomain, GDAP2-like family; Macrodomains are found in a variety of proteins with diverse cellular functions, as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Macrodomains can recognize ADP-ribose (ADPr) in both its free and protein-linked forms, in related ligands, such as O-acyl-ADP-ribose (OAADPr), and even in ligands unrelated to ADPr. This family contains proteins similar to human GDAP2, the ganglioside induced differentiation associated protein 2, whose gene is expressed at a higher level in differentiated Neuro2a cells compared with non-differentiated cells. GDAP2 contains an N-terminal macrodomain and a C-terminal Sec14p-like lipid binding domain. It is specifically expressed in brain and testis.


Pssm-ID: 394876  Cd Length: 169  Bit Score: 37.60  E-value: 1.20e-03
                          10        20
                  ....*....|....*....|
gi 1958642382 151 KISLFRGDITKLEVDAIVNA 170
Cdd:cd02905     2 KIVLWDGDLTLLNVDAIVNS 21
A1pp smart00506
Appr-1"-p processing enzyme; Function determined by Martzen et al. Extended family detected by ...
 151-170 2.88e-03

Appr-1"-p processing enzyme; Function determined by Martzen et al. Extended family detected by reciprocal PSI-BLAST searches (unpublished results, and Pehrson _ Fuji).


Pssm-ID: 214701  Cd Length: 133  Bit Score: 36.13  E-value: 2.88e-03
                           10        20
                   ....*....|....*....|
gi 1958642382  151 KISLFRGDITKLEVDAIVNA 170
Cdd:smart00506   1 ILKVVKGDITKPRADAIVNA 20
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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