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Conserved domains on  [gi|1958757917|ref|XP_038954925|]
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G patch domain and ankyrin repeat-containing protein 1 isoform X3 [Rattus norvegicus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
113-203 1.58e-11

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 62.28  E-value: 1.58e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757917 113 ILMAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCELGGRDAAQLAEEA 192
Cdd:COG0666   157 LHLAAANGNLEIVKLLLE------AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD-VNAKDNDGKTALDLAAEN 229

                          90
                  ....*....|.
gi 1958757917 193 GFPEVARMVRE 203
Cdd:COG0666   230 GNLEIVKLLLE 240
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
113-203 1.58e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 62.28  E-value: 1.58e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757917 113 ILMAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCELGGRDAAQLAEEA 192
Cdd:COG0666   157 LHLAAANGNLEIVKLLLE------AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD-VNAKDNDGKTALDLAAEN 229

                          90
                  ....*....|.
gi 1958757917 193 GFPEVARMVRE 203
Cdd:COG0666   230 GNLEIVKLLLE 240
Ank_2 pfam12796
Ankyrin repeats (3 copies);
113-200 9.92e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.97  E-value: 9.92e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757917 113 ILMAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAWvgvCELGGRDAAQLAEEA 192
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLE------NGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN---LKDNGRTALHYAARS 71


                  ....*...
gi 1958757917 193 GFPEVARM 200
Cdd:pfam12796  72 GHLEIVKL 79
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
113-203 1.58e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 62.28  E-value: 1.58e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757917 113 ILMAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCELGGRDAAQLAEEA 192
Cdd:COG0666   157 LHLAAANGNLEIVKLLLE------AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD-VNAKDNDGKTALDLAAEN 229

                          90
                  ....*....|.
gi 1958757917 193 GFPEVARMVRE 203
Cdd:COG0666   230 GNLEIVKLLLE 240
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
113-200 9.04e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 60.35  E-value: 9.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757917 113 ILMAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCELGGRDAAQLAEEA 192
Cdd:COG0666    91 LHAAARNGDLEIVKLLLE------AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGAD-VNAQDNDGNTPLHLAAAN 163


                  ....*...
gi 1958757917 193 GFPEVARM 200
Cdd:COG0666   164 GNLEIVKL 171
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
113-200 2.29e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 59.20  E-value: 2.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757917 113 ILMAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCELGGRDAAQLAEEA 192
Cdd:COG0666   124 LHLAAYNGNLEIVKLLLE------AGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD-VNARDNDGETPLHLAAEN 196


                  ....*...
gi 1958757917 193 GFPEVARM 200
Cdd:COG0666   197 GHLEIVKL 204
Ank_2 pfam12796
Ankyrin repeats (3 copies);
113-200 9.92e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.97  E-value: 9.92e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757917 113 ILMAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAWvgvCELGGRDAAQLAEEA 192
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLE------NGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN---LKDNGRTALHYAARS 71


                  ....*...
gi 1958757917 193 GFPEVARM 200
Cdd:pfam12796  72 GHLEIVKL 79
Ank_4 pfam13637
Ankyrin repeats (many copies);
113-168 1.50e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.88  E-value: 1.50e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958757917 113 ILMAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLL 168
Cdd:pfam13637   5 LHAAAASGHLELLRLLLE------KGADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
115-200 3.44e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 46.87  E-value: 3.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757917 115 MAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAWVGVCELGGRDAAQLAEEAGF 194
Cdd:COG0666   192 LAAENGHLEIVKLLLE------AGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAA 265


                  ....*.
gi 1958757917 195 PEVARM 200
Cdd:COG0666   266 LIVKLL 271
Ank_2 pfam12796
Ankyrin repeats (3 copies);
113-172 6.22e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 43.57  E-value: 6.22e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958757917 113 ILM-AAQNGDLTELRRLLEpqeaggaGGNINARDAFWwTPLMCAARAGQGAAVRYLLGRGA 172
Cdd:pfam12796  33 ALHlAAKNGHLEIVKLLLE-------HADVNLKDNGR-TALHYAARSGHLEIVKLLLEKGA 85
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
114-200 1.09e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 42.25  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757917 114 LMAAQNGDLTELRRLLEpqeagGAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCELGGRDAAQLAEEAG 193
Cdd:COG0666    58 LLAAALAGDLLVALLLL-----AAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD-VNARDKDGETPLHLAAYNG 131


                  ....*..
gi 1958757917 194 FPEVARM 200
Cdd:COG0666   132 NLEIVKL 138
Ank_5 pfam13857
Ankyrin repeats (many copies);
140-189 9.07e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 33.47  E-value: 9.07e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958757917 140 NINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAWvGVCELGGRDAAQLA 189
Cdd:pfam13857   8 DLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDL-NLKDEEGLTALDLA 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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