Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1958756701  713 GQHSGDGFKPCQPCPRGTYQPEAGRTLCFPCGGGLTTKHEGAVSFQDC 760
Cdd:pfam07699    1 GTYSNTGLEPCIPCPRGTYQPEEGQLSCLACPLGTTTDSPGATSISDC 48

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958756701   33 CVEGTDHCHIDAICQNTPRSYKCICKSGYTGDGKHC 68
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958756701  256 CAVNNGGCDSKCHDAATGVHCSCPVGFMLQPDRKTC 291
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958756701  297 CRLHNGGCDHICRNTVGSFECSCKKGYKLLINERSC 332
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|..
gi 1958756701   334 DIDECSFDRTCDH--MCVNTPGSFQCLCHRGY 363
Cdd:smart00179    1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY 32

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1958756701   373 DVDECSiNKGGCRFG--CINTPGSYQCTCPAGqgrlHWNGKDCT 414
Cdd:smart00179    1 DIDECA-SGNPCQNGgtCVNTVGSYRCECPPG----YTDGRNCE 39

CUB domain;

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958756701  821 CGGELGEFTGYIESPNYPGNYPAGVECIWNINPPPKRKILIVVPEIFLPSEDECG-DVLVMRKNSSPSSITTYETCqTYE 899
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGyDYVEIRDGPSASSPLLGRFC-GSG 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1958756701  900 RPIAFTARSRKLWINFKTSEANSARGFQIPY 930
Cdd:pfam00431   80 IPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1958756701  713 GQHSGDGFKPCQPCPRGTYQPEAGRTLCFPCGGGLTTKHEGAVSFQDC 760
Cdd:pfam07699    1 GTYSNTGLEPCIPCPRGTYQPEEGQLSCLACPLGTTTDSPGATSISDC 48

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958756701   33 CVEGTDHCHIDAICQNTPRSYKCICKSGYTGDGKHC 68
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958756701  256 CAVNNGGCDSKCHDAATGVHCSCPVGFMLQPDRKTC 291
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958756701  297 CRLHNGGCDHICRNTVGSFECSCKKGYKLLINERSC 332
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|..
gi 1958756701   334 DIDECSFDRTCDH--MCVNTPGSFQCLCHRGY 363
Cdd:smart00179    1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY 32

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1958756701  329 ERSCQDIDECS-FDRTCDHMCVNTPGSFQCLCHRGYLL 365
Cdd:cd01475    181 GKICVVPDLCAtLSHVCQQVCISTPGSYLCACTEGYAL 218

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1958756701    70 DVDECEREDNAGCVHDCVNIPGNYRCTCYDGFhlaHDGHNC 110
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNC 38

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1958756701  289 KTCKDIDECRLHNGGCDHICRNTVGSFECSCKKGYKLLINERS 331
Cdd:cd01475    182 KICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958756701  161 CMNKNHGCAHICRETPkGGIACECRPGFELTKNQRDC 197
Cdd:pfam14670    1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|..
gi 1958756701   293 DIDECRLHNG-GCDHICRNTVGSFECSCKKGY 323
Cdd:smart00179    1 DIDECASGNPcQNGGTCVNTVGSYRCECPPGY 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958756701   70 DVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAH 105
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958756701  373 DVDECSINkGGCRFG--CINTPGSYQCTCPAG 402
Cdd:cd00054      1 DIDECASG-NPCQNGgtCVNTVGSYRCSCPPG 31

CUB domain;

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958756701  821 CGGELGEFTGYIESPNYPGNYPAGVECIWNINPPPKRKILIVVPEIFLPSEDECG-DVLVMRKNSSPSSITTYETCqTYE 899
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGyDYVEIRDGPSASSPLLGRFC-GSG 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1958756701  900 RPIAFTARSRKLWINFKTSEANSARGFQIPY 930
Cdd:pfam00431   80 IPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1958756701  713 GQHSGDGFKPCQPCPRGTYQPEAGRTLCFPCGGGLTTKHEGAVSFQDC 760
Cdd:pfam07699    1 GTYSNTGLEPCIPCPRGTYQPEEGQLSCLACPLGTTTDSPGATSISDC 48

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958756701   33 CVEGTDHCHIDAICQNTPRSYKCICKSGYTGDGKHC 68
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958756701  256 CAVNNGGCDSKCHDAATGVHCSCPVGFMLQPDRKTC 291
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958756701   29 DVDECVEGTDHCHIDAICQNTPRSYKCICKSG 60
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958756701  201 CNYGNGGCQHTCDDTEQGPRCGCHVKFVLHTDGKTC 236
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1958756701  110 CLDVDECAEGNGGCQQSCVNMMGSYECHCRDGFFLSDNQHT 150
Cdd:cd01475    184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1958756701    29 DVDECVEGtDHCHIDAICQNTPRSYKCICKSGYTgDGKHCK 69
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1958756701   29 DVDECVEGtDHCHIDAICQNTPRSYKCICKSGYTgdGKHCK 69
Cdd:cd00054      1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYT--GRNCE 38

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1958756701   373 DVDECSiNKGGCRFG--CINTPGSYQCTCPAGqgrlHWNGKDCT 414
Cdd:smart00179    1 DIDECA-SGNPCQNGgtCVNTVGSYRCECPPG----YTDGRNCE 39

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|..
gi 1958756701   112 DVDECAEGNG-GCQQSCVNMMGSYECHCRDGF 142
Cdd:smart00179    1 DIDECASGNPcQNGGTCVNTVGSYRCECPPGY 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....
gi 1958756701  293 DIDECRLHNG-GCDHICRNTVGSFECSCKKGYKL 325
Cdd:cd00054      1 DIDECASGNPcQNGGTCVNTVGSYRCSCPPGYTG 34

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.

                           10        20
                   ....*....|....*....|..
gi 1958756701  275 HCSCPVGFMLQPDRKTCKDIDE 296
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958756701   70 DVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAH 105
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958756701  373 DVDECSINkGGCRFG--CINTPGSYQCTCPAG 402
Cdd:cd00054      1 DIDECASG-NPCQNGgtCVNTVGSYRCSCPPG 31

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958756701  112 DVDECAEGNG-GCQQSCVNMMGSYECHCRDGF 142
Cdd:cd00054      1 DIDECASGNPcQNGGTCVNTVGSYRCSCPPGY 32

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                           10        20        30
                   ....*....|....*....|....*....|
gi 1958756701  297 CRLHNGGCDH--ICRNTVGSFECSCKKGYK 324
Cdd:pfam12947    1 CSDNNGGCHPnaTCTNTGGSFTCTCNDGYT 30

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.

                           10        20
                   ....*....|....*....|.
gi 1958756701  317 CSCKKGYKLLINERSCQDIDE 337
Cdd:pfam12662    2 CSCPPGYQLDPDGRTCVDIDE 22