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Conserved domains on  [gi|1958746412|ref|XP_038953595|]
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protein ARV1 isoform X3 [Rattus norvegicus]

Protein Classification

ARV1 family protein( domain architecture ID 231197)

ARV1 (ARE2 required for viability) family protein functions as a mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes, and also regulates sphingolipid metabolism

Gene Ontology:  GO:0032366|GO:0006665|GO:0016125
TCDB:  9.A.19

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arv1 super family cl21705
Arv1-like family; Arv1 is a transmembrane protein with potential zinc-binding motifs. ARV1 is ...
 2-42 5.41e-08

Arv1-like family; Arv1 is a transmembrane protein with potential zinc-binding motifs. ARV1 is a novel mediator of eukaryotic sterol homeostasis.


The actual alignment was detected with superfamily member pfam04161:

Pssm-ID: 473938  Cd Length: 204  Bit Score: 50.32  E-value: 5.41e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958746412   2 FCLLCEAYLRWWQL----QDSSQSPAPDDVIRYAKEWDFYRMFVI 42
Cdd:pfam04161  83 LLLLFEVYLTWAREekdtSGSSSLSISAIVLLSLKPLDQYLFFLL 127
 
Name Accession Description Interval E-value
Arv1 pfam04161
Arv1-like family; Arv1 is a transmembrane protein with potential zinc-binding motifs. ARV1 is ...
 2-42 5.41e-08

Arv1-like family; Arv1 is a transmembrane protein with potential zinc-binding motifs. ARV1 is a novel mediator of eukaryotic sterol homeostasis.


Pssm-ID: 461202  Cd Length: 204  Bit Score: 50.32  E-value: 5.41e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958746412   2 FCLLCEAYLRWWQL----QDSSQSPAPDDVIRYAKEWDFYRMFVI 42
Cdd:pfam04161  83 LLLLFEVYLTWAREekdtSGSSSLSISAIVLLSLKPLDQYLFFLL 127
 
Name Accession Description Interval E-value
Arv1 pfam04161
Arv1-like family; Arv1 is a transmembrane protein with potential zinc-binding motifs. ARV1 is ...
 2-42 5.41e-08

Arv1-like family; Arv1 is a transmembrane protein with potential zinc-binding motifs. ARV1 is a novel mediator of eukaryotic sterol homeostasis.


Pssm-ID: 461202  Cd Length: 204  Bit Score: 50.32  E-value: 5.41e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958746412   2 FCLLCEAYLRWWQL----QDSSQSPAPDDVIRYAKEWDFYRMFVI 42
Cdd:pfam04161  83 LLLLFEVYLTWAREekdtSGSSSLSISAIVLLSLKPLDQYLFFLL 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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