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Conserved domains on  [gi|1958740175|ref|XP_038952518|]
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netrin receptor DCC isoform X8 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Neogenin_C pfam06583
Neogenin C-terminus; This family represents the C-terminus of eukaryotic neogenin precursor ...
 652-949 4.33e-127

Neogenin C-terminus; This family represents the C-terminus of eukaryotic neogenin precursor proteins, which contains several potential phosphorylation sites. Neogenin is a member of the N-CAM family of cell adhesion molecules (and therefore contains multiple copies of pfam00047 and pfam00041) and is closely related to the DCC tumour suppressor gene product - these proteins may play an integral role in regulating differentiation programmes and/or cell migration events within many adult and embryonic tissues.


:

Pssm-ID: 461954 [Multi-domain]  Cd Length: 289  Bit Score: 385.81  E-value: 4.33e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 652 LRPPDLWIHHEEMEMKNIEKPAGTDPAGRGSPI-QSCQDLTPVSHSQSESQMGSKSASHSGQDTEEAGSSmstlersLAA 730
Cdd:pfam06583   1 LKPPDLWIHHEQMELKNIEKSPSPNPSGTDSPIgQSSQDLPPVDHSQSESQIHQKSNSYSGNDSDEKSST-------LAG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 731 RRATRTKLMIPMEAQSNNPAVVSAIPVPTLESAQ---YPGILPSPTCGYPHPQFTLrpvPFPTLSVDRGFGAGRSQSVSE 807
Cdd:pfam06583  74 RRGTRPKMMLPMDSQPSNQPVVSAIPIPSLDSSHqyaHPGILPSPTCGYLHNQFSL---PFPGTPVPRSDTAPSAESVEN 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 808 GPTAQQQPMLPPAQPEHP----SSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSaiepkvPYTPLLSQPGPTLPKTHV 883
Cdd:pfam06583 151 TPLQSQLPYQPSSQSESGslssAVEEEPNRSIPTAKVRPGHPLKSFSVPAPPPQSA------PSTPLQQQHRPTLSKSPV 224

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958740175 884 KTASLGLAGKARSPLlPVSVPTAPEVSEESHKPTEDPASVYEQDDLSEQMASLEGLMKQLNAITGS 949
Cdd:pfam06583 225 KTASLGTAGKARSPL-PVSVPNAPDTSEETERLLEDAAPSYETDELSEEMANLEGLMKDLNAITAS 289
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1-405 4.12e-22

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 102.00  E-value: 4.12e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175   1 MYTFRVVAYNEWGPGESSQPIKVATQPELqvPGPVENLHAVSASPTSILITWEPPayANGPVQGYRLFCTEVSTGKEQNI 80
Cdd:COG3401   204 TYYYRVAATDTGGESAPSNEVSVTTPTTP--PSAPTGLTATADTPGSVTLSWDPV--TESDATGYRVYRSNSGDGPFTKV 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175  81 -EVDGLSYKLEGLKKFTEYTLRFLAYNRYG-PGVSTDDITVVTLSDVPsAPPQNVSLEVVNSRSIKVSWlpppSGTQNGF 158
Cdd:COG3401   280 aTVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPP-AAPSGLTATAVGSSSITLSW----TASSDAD 354

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 159 ITGYKIrHRKTTRRGEMETL--EPNNLWYLFTGLEKGSQYSFQVSAMTVNGT-GPPSNWYTAETPENDLDES--QVPDQP 233
Cdd:COG3401   355 VTGYNV-YRSTSGGGTYTKIaeTVTTTSYTDTGLTPGTTYYYKVTAVDAAGNeSAPSEEVSATTASAASGESltASVDAV 433

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 234 SSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGV-GSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPL 312
Cdd:COG3401   434 PLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVpFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIG 513

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 313 YESATTRSITDPTDPVDYYPLLDDFPTSGPDVSTPMLPPVGVQAVAltheavrvSWADNSVPKNQKTSDVRLYTVRWRTS 392
Cdd:COG3401   514 ASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASS--------SVSGAGLGSGNLYLITTLGGSLLTTT 585

                         410
                  ....*....|...
gi 1958740175 393 FSASAKYKSEDTT 405
Cdd:COG3401   586 STNTNDVAGVHGG 598
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 450-545 8.85e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.91  E-value: 8.85e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 450 SAPKDLTVitREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNipiDDWI-METISGDRLTHQIMDLSLDTMYYFRIQA 528
Cdd:cd00063     2 SPPTNLRV--TDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGS---GDWKeVEVTPGSETSYTLTGLKPGTEYEFRVRA 76

                          90
                  ....*....|....*..
gi 1958740175 529 RNAKGVGPLSDPILFRT 545
Cdd:cd00063    77 VNGGGESPPSESVTVTT 93
 
Name Accession Description Interval E-value
Neogenin_C pfam06583
Neogenin C-terminus; This family represents the C-terminus of eukaryotic neogenin precursor ...
 652-949 4.33e-127

Neogenin C-terminus; This family represents the C-terminus of eukaryotic neogenin precursor proteins, which contains several potential phosphorylation sites. Neogenin is a member of the N-CAM family of cell adhesion molecules (and therefore contains multiple copies of pfam00047 and pfam00041) and is closely related to the DCC tumour suppressor gene product - these proteins may play an integral role in regulating differentiation programmes and/or cell migration events within many adult and embryonic tissues.


Pssm-ID: 461954 [Multi-domain]  Cd Length: 289  Bit Score: 385.81  E-value: 4.33e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 652 LRPPDLWIHHEEMEMKNIEKPAGTDPAGRGSPI-QSCQDLTPVSHSQSESQMGSKSASHSGQDTEEAGSSmstlersLAA 730
Cdd:pfam06583   1 LKPPDLWIHHEQMELKNIEKSPSPNPSGTDSPIgQSSQDLPPVDHSQSESQIHQKSNSYSGNDSDEKSST-------LAG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 731 RRATRTKLMIPMEAQSNNPAVVSAIPVPTLESAQ---YPGILPSPTCGYPHPQFTLrpvPFPTLSVDRGFGAGRSQSVSE 807
Cdd:pfam06583  74 RRGTRPKMMLPMDSQPSNQPVVSAIPIPSLDSSHqyaHPGILPSPTCGYLHNQFSL---PFPGTPVPRSDTAPSAESVEN 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 808 GPTAQQQPMLPPAQPEHP----SSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSaiepkvPYTPLLSQPGPTLPKTHV 883
Cdd:pfam06583 151 TPLQSQLPYQPSSQSESGslssAVEEEPNRSIPTAKVRPGHPLKSFSVPAPPPQSA------PSTPLQQQHRPTLSKSPV 224

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958740175 884 KTASLGLAGKARSPLlPVSVPTAPEVSEESHKPTEDPASVYEQDDLSEQMASLEGLMKQLNAITGS 949
Cdd:pfam06583 225 KTASLGTAGKARSPL-PVSVPNAPDTSEETERLLEDAAPSYETDELSEEMANLEGLMKDLNAITAS 289
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1-405 4.12e-22

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 102.00  E-value: 4.12e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175   1 MYTFRVVAYNEWGPGESSQPIKVATQPELqvPGPVENLHAVSASPTSILITWEPPayANGPVQGYRLFCTEVSTGKEQNI 80
Cdd:COG3401   204 TYYYRVAATDTGGESAPSNEVSVTTPTTP--PSAPTGLTATADTPGSVTLSWDPV--TESDATGYRVYRSNSGDGPFTKV 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175  81 -EVDGLSYKLEGLKKFTEYTLRFLAYNRYG-PGVSTDDITVVTLSDVPsAPPQNVSLEVVNSRSIKVSWlpppSGTQNGF 158
Cdd:COG3401   280 aTVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPP-AAPSGLTATAVGSSSITLSW----TASSDAD 354

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 159 ITGYKIrHRKTTRRGEMETL--EPNNLWYLFTGLEKGSQYSFQVSAMTVNGT-GPPSNWYTAETPENDLDES--QVPDQP 233
Cdd:COG3401   355 VTGYNV-YRSTSGGGTYTKIaeTVTTTSYTDTGLTPGTTYYYKVTAVDAAGNeSAPSEEVSATTASAASGESltASVDAV 433

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 234 SSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGV-GSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPL 312
Cdd:COG3401   434 PLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVpFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIG 513

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 313 YESATTRSITDPTDPVDYYPLLDDFPTSGPDVSTPMLPPVGVQAVAltheavrvSWADNSVPKNQKTSDVRLYTVRWRTS 392
Cdd:COG3401   514 ASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASS--------SVSGAGLGSGNLYLITTLGGSLLTTT 585

                         410
                  ....*....|...
gi 1958740175 393 FSASAKYKSEDTT 405
Cdd:COG3401   586 STNTNDVAGVHGG 598
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 32-121 4.31e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 80.23  E-value: 4.31e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175  32 PGPVENLHAVSASPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEV---DGLSYKLEGLKKFTEYTLRFLAYNRY 108
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpgSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 1958740175 109 GPGVSTDDITVVT 121
Cdd:cd00063    81 GESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 129-209 3.22e-15

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 71.49  E-value: 3.22e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175  129 PPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGT 208
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82


                   .
gi 1958740175  209 G 209
Cdd:smart00060  83 G 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 450-545 8.85e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.91  E-value: 8.85e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 450 SAPKDLTVitREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNipiDDWI-METISGDRLTHQIMDLSLDTMYYFRIQA 528
Cdd:cd00063     2 SPPTNLRV--TDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGS---GDWKeVEVTPGSETSYTLTGLKPGTEYEFRVRA 76

                          90
                  ....*....|....*..
gi 1958740175 529 RNAKGVGPLSDPILFRT 545
Cdd:cd00063    77 VNGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
33-111 1.02e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.44  E-value: 1.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175  33 GPVENLHAVSASPTSILITWEPPAYANGPVQGYRLFCTEVSTGK-EQNIEVDG--LSYKLEGLKKFTEYTLRFLAYNRYG 109
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEpWNEITVPGttTSVTLTGLKPGTEYEVRVQAVNGGG 80


                  ..
gi 1958740175 110 PG 111
Cdd:pfam00041  81 EG 82
fn3 pfam00041
Fibronectin type III domain;
450-538 3.24e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 3.24e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 450 SAPKDLTVITREgkPRAVIVSWQPPLEANGKITAYILFY-TLDKNipiDDWIMETISGDRLTHQIMDLSLDTMYYFRIQA 528
Cdd:pfam00041   1 SAPSNLTVTDVT--STSLTVSWTPPPDGNGPITGYEVEYrPKNSG---EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75

                          90
                  ....*....|
gi 1958740175 529 RNAKGVGPLS 538
Cdd:pfam00041  76 VNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 450-535 8.36e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 59.17  E-value: 8.36e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175  450 SAPKDLTVITREgkPRAVIVSWQPPLEANGkiTAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLSLDTMYYFRIQAR 529
Cdd:smart00060   2 SPPSNLRVTDVT--STSVTLSWEPPPDDGI--TGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                   ....*.
gi 1958740175  530 NAKGVG 535
Cdd:smart00060  78 NGAGEG 83
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 646-931 9.41e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 49.69  E-value: 9.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 646 KGSQKDLRPPDlwihhEEMEMKNIEKPAGtdPAGRGSPiqscqdltPVSHSQSESQMGSKSASHSGQDTEEAGSSMSTLE 725
Cdd:PTZ00449  490 KKSKKKLAPIE-----EEDSDKHDEPPEG--PEASGLP--------PKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKE 554

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 726 RSLAARratrtklmiPMEAQSNNPavvSAIPVPTlESAQYPGILPSPTcGYPHPQFTLRPVpfptlsvdrgfgagrsqsV 805
Cdd:PTZ00449  555 GEVGKK---------PGPAKEHKP---SKIPTLS-KKPEFPKDPKHPK-DPEEPKKPKRPR------------------S 602

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 806 SEGPTAQQQPMLP-----PAQPEHPSSEEAPSRTIPTAcvRPTHPLRSFANPLLPPPMSAIEPKVPYTPLL--------- 871
Cdd:PTZ00449  603 AQRPTRPKSPKLPelldiPKSPKRPESPKSPKRPPPPQ--RPSSPERPEGPKIIKSPKPPKSPKPPFDPKFkekfyddyl 680

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 872 -----SQPGPTLPKTHVKTASLGLAGKARSPLLPVSV-----PTAPEVSEESHKPTEDPASvyEQDDLSE 931
Cdd:PTZ00449  681 daaakSKETKTTVVLDESFESILKETLPETPGTPFTTprplpPKLPRDEEFPFEPIGDPDA--EQPDDIE 748
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
344-533 2.41e-04

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 44.94  E-value: 2.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 344 VSTPMLPPVGVQAVALTheaVRVSWADNSVpkNQKTSDVRLyTVRWRTS---FSASAKYKSED--------TTSLSYTAT 412
Cdd:COG4733   519 IDAGAFDDVPPQWPPVN---VTTSESLSVV--AQGTAVTTL-TVSWDAPagaVAYEVEWRRDDgnwvsvprTSGTSFEVP 592

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 413 GLKPNTmYEFSVM-VTKNRRSSTWSMTAHAT-TYEAAPTSAPKDLTVitrEGKPRAVIVSWQPPLEANgkITAYILFYTl 490
Cdd:COG4733   593 GIYAGD-YEVRVRaINALGVSSAWAASSETTvTGKTAPPPAPTGLTA---TGGLGGITLSWSFPVDAD--TLRTEIRYS- 665

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1958740175 491 dkniPIDDW---IMETISGDRLTHQIMDLSLDTMYYFRIQARNAKG 533
Cdd:COG4733   666 ----TTGDWasaTVAQALYPGNTYTLAGLKAGQTYYYRARAVDRSG 707
 
Name Accession Description Interval E-value
Neogenin_C pfam06583
Neogenin C-terminus; This family represents the C-terminus of eukaryotic neogenin precursor ...
 652-949 4.33e-127

Neogenin C-terminus; This family represents the C-terminus of eukaryotic neogenin precursor proteins, which contains several potential phosphorylation sites. Neogenin is a member of the N-CAM family of cell adhesion molecules (and therefore contains multiple copies of pfam00047 and pfam00041) and is closely related to the DCC tumour suppressor gene product - these proteins may play an integral role in regulating differentiation programmes and/or cell migration events within many adult and embryonic tissues.


Pssm-ID: 461954 [Multi-domain]  Cd Length: 289  Bit Score: 385.81  E-value: 4.33e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 652 LRPPDLWIHHEEMEMKNIEKPAGTDPAGRGSPI-QSCQDLTPVSHSQSESQMGSKSASHSGQDTEEAGSSmstlersLAA 730
Cdd:pfam06583   1 LKPPDLWIHHEQMELKNIEKSPSPNPSGTDSPIgQSSQDLPPVDHSQSESQIHQKSNSYSGNDSDEKSST-------LAG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 731 RRATRTKLMIPMEAQSNNPAVVSAIPVPTLESAQ---YPGILPSPTCGYPHPQFTLrpvPFPTLSVDRGFGAGRSQSVSE 807
Cdd:pfam06583  74 RRGTRPKMMLPMDSQPSNQPVVSAIPIPSLDSSHqyaHPGILPSPTCGYLHNQFSL---PFPGTPVPRSDTAPSAESVEN 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 808 GPTAQQQPMLPPAQPEHP----SSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSaiepkvPYTPLLSQPGPTLPKTHV 883
Cdd:pfam06583 151 TPLQSQLPYQPSSQSESGslssAVEEEPNRSIPTAKVRPGHPLKSFSVPAPPPQSA------PSTPLQQQHRPTLSKSPV 224

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958740175 884 KTASLGLAGKARSPLlPVSVPTAPEVSEESHKPTEDPASVYEQDDLSEQMASLEGLMKQLNAITGS 949
Cdd:pfam06583 225 KTASLGTAGKARSPL-PVSVPNAPDTSEETERLLEDAAPSYETDELSEEMANLEGLMKDLNAITAS 289
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1-405 4.12e-22

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 102.00  E-value: 4.12e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175   1 MYTFRVVAYNEWGPGESSQPIKVATQPELqvPGPVENLHAVSASPTSILITWEPPayANGPVQGYRLFCTEVSTGKEQNI 80
Cdd:COG3401   204 TYYYRVAATDTGGESAPSNEVSVTTPTTP--PSAPTGLTATADTPGSVTLSWDPV--TESDATGYRVYRSNSGDGPFTKV 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175  81 -EVDGLSYKLEGLKKFTEYTLRFLAYNRYG-PGVSTDDITVVTLSDVPsAPPQNVSLEVVNSRSIKVSWlpppSGTQNGF 158
Cdd:COG3401   280 aTVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPP-AAPSGLTATAVGSSSITLSW----TASSDAD 354

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 159 ITGYKIrHRKTTRRGEMETL--EPNNLWYLFTGLEKGSQYSFQVSAMTVNGT-GPPSNWYTAETPENDLDES--QVPDQP 233
Cdd:COG3401   355 VTGYNV-YRSTSGGGTYTKIaeTVTTTSYTDTGLTPGTTYYYKVTAVDAAGNeSAPSEEVSATTASAASGESltASVDAV 433

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 234 SSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGV-GSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPL 312
Cdd:COG3401   434 PLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVpFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIG 513

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 313 YESATTRSITDPTDPVDYYPLLDDFPTSGPDVSTPMLPPVGVQAVAltheavrvSWADNSVPKNQKTSDVRLYTVRWRTS 392
Cdd:COG3401   514 ASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASS--------SVSGAGLGSGNLYLITTLGGSLLTTT 585

                         410
                  ....*....|...
gi 1958740175 393 FSASAKYKSEDTT 405
Cdd:COG3401   586 STNTNDVAGVHGG 598
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
70-501 9.77e-19

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 91.22  E-value: 9.77e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175  70 TEVSTGKEQNIEVDGLSYKLEGLKKFTEYTLRFLAYNRYGPGVSTDDITVVTLSDVPSaPPQNVSLEVVNSRSIKVSWLP 149
Cdd:COG3401   177 TAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPS-APTGLTATADTPGSVTLSWDP 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 150 PPsgtqNGFITGYKIrHRKTTRRGEMETL-EPNNLWYLFTGLEKGSQYSFQVSAMTVNGT-GPPSNWYTAETpendldES 227
Cdd:COG3401   256 VT----ESDATGYRV-YRSNSGDGPFTKVaTVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTT------DL 324

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 228 QVPDQPSSLHVRPQTNCIIM-SWTPPLNPNIVvrGYII--GYGVGSPYaETVRVDSKQRYYSIERLESSSHYVISLKAFN 304
Cdd:COG3401   325 TPPAAPSGLTATAVGSSSITlSWTASSDADVT--GYNVyrSTSGGGTY-TKIAETVTTTSYTDTGLTPGTTYYYKVTAVD 401

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 305 NAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSGPDVSTPML----PPVGVQAVALTHEAVRVSWADNSVPKNQKTS 380
Cdd:COG3401   402 AAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASaasnPGVSAAVLADGGDTGNAVPFTTTSSTVTATT 481

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 381 DVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTkNRRSSTWSMTAHATTYEAAPTSAPKDLTVITR 460
Cdd:COG3401   482 TDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTP-NVTGASPVTVGASTGDVLITDLVSLTTSASSS 560

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1958740175 461 EGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIM 501
Cdd:COG3401   561 VSGAGLGSGNLYLITTLGGSLLTTTSTNTNDVAGVHGGTLL 601
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 32-121 4.31e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 80.23  E-value: 4.31e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175  32 PGPVENLHAVSASPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEV---DGLSYKLEGLKKFTEYTLRFLAYNRY 108
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpgSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 1958740175 109 GPGVSTDDITVVT 121
Cdd:cd00063    81 GESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 129-219 2.33e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 75.23  E-value: 2.33e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 129 PPQNVSLEVVNSRSIKVSWLPPPSGtqNGFITGYKIRHRKTTRRG--EMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVN 206
Cdd:cd00063     3 PPTNLRVTDVTSTSVTLSWTPPEDD--GGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 1958740175 207 GTGPPSNWYTAET 219
Cdd:cd00063    81 GESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 129-209 3.22e-15

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 71.49  E-value: 3.22e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175  129 PPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGT 208
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82


                   .
gi 1958740175  209 G 209
Cdd:smart00060  83 G 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
96-541 3.56e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.58  E-value: 3.56e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175  96 TEYTLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEm 175
Cdd:COG3401     1 TGSSYLTSLDAGIAASAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGV- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 176 eTLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPEN-DLDESQVPDQPSSLHVRPQTNCIIMSWTPPLN 254
Cdd:COG3401    80 -AAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTAtTATAVAGGAATAGTYALGAGLYGVDGANASGT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 255 PNIVVRGYIIGYGVGSPYAETV-----RVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPlyesATTRSITDPTdpvd 329
Cdd:COG3401   159 TASSVAGAGVVVSPDTSATAAVattslTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAP----SNEVSVTTPT---- 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 330 yypllddfptsgpdvsTPMLPPVGVQAVALTHEAVRVSWADNSVPknqktsDVRLYTVRWRTSfsASAKYKS-EDTTSLS 408
Cdd:COG3401   231 ----------------TPPSAPTGLTATADTPGSVTLSWDPVTES------DATGYRVYRSNS--GDGPFTKvATVTTTS 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 409 YTATGLKPNTMYEFSVM-VTKNRRSSTWSMTAHATTYEAAPTsAPKDLTVITREgkPRAVIVSWQPPleANGKITAYILF 487
Cdd:COG3401   287 YTDTGLTNGTTYYYRVTaVDAAGNESAPSNVVSVTTDLTPPA-APSGLTATAVG--SSSITLSWTAS--SDADVTGYNVY 361

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958740175 488 YTLDKNIPIDdWIMETISGdrLTHQIMDLSLDTMYYFRIQARNAKGV-GPLSDPI 541
Cdd:COG3401   362 RSTSGGGTYT-KIAETVTT--TSYTDTGLTPGTTYYYKVTAVDAAGNeSAPSEEV 413
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 450-545 8.85e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.91  E-value: 8.85e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 450 SAPKDLTVitREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNipiDDWI-METISGDRLTHQIMDLSLDTMYYFRIQA 528
Cdd:cd00063     2 SPPTNLRV--TDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGS---GDWKeVEVTPGSETSYTLTGLKPGTEYEFRVRA 76

                          90
                  ....*....|....*..
gi 1958740175 529 RNAKGVGPLSDPILFRT 545
Cdd:cd00063    77 VNGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
33-111 1.02e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.44  E-value: 1.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175  33 GPVENLHAVSASPTSILITWEPPAYANGPVQGYRLFCTEVSTGK-EQNIEVDG--LSYKLEGLKKFTEYTLRFLAYNRYG 109
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEpWNEITVPGttTSVTLTGLKPGTEYEVRVQAVNGGG 80


                  ..
gi 1958740175 110 PG 111
Cdd:pfam00041  81 EG 82
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 32-111 1.59e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 66.87  E-value: 1.59e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175   32 PGPVENLHAVSASPTSILITWEPPAYAN--GPVQGYRL-FCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYTLRFLAYNRY 108
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVeYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 1958740175  109 GPG 111
Cdd:smart00060  81 GEG 83
fn3 pfam00041
Fibronectin type III domain;
450-538 3.24e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 3.24e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 450 SAPKDLTVITREgkPRAVIVSWQPPLEANGKITAYILFY-TLDKNipiDDWIMETISGDRLTHQIMDLSLDTMYYFRIQA 528
Cdd:pfam00041   1 SAPSNLTVTDVT--STSLTVSWTPPPDGNGPITGYEVEYrPKNSG---EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75

                          90
                  ....*....|
gi 1958740175 529 RNAKGVGPLS 538
Cdd:pfam00041  76 VNGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
129-212 6.80e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.13  E-value: 6.80e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 129 PPQNVSLEVVNSRSIKVSWLPPPSGtqNGFITGYKIRHRKTTRRGEM--ETLEPNNLWYLFTGLEKGSQYSFQVSAMTVN 206
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDG--NGPITGYEVEYRPKNSGEPWneITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                  ....*.
gi 1958740175 207 GTGPPS 212
Cdd:pfam00041  80 GEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 450-535 8.36e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 59.17  E-value: 8.36e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175  450 SAPKDLTVITREgkPRAVIVSWQPPLEANGkiTAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLSLDTMYYFRIQAR 529
Cdd:smart00060   2 SPPSNLRVTDVT--STSVTLSWEPPPDDGI--TGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                   ....*.
gi 1958740175  530 NAKGVG 535
Cdd:smart00060  78 NGAGEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
2-303 4.76e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 63.48  E-value: 4.76e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175   2 YTFRVVAYNEWG-PGESSQPIKVATQPELqvPGPVENLHAVSASPTSILITWEPPayANGPVQGYRLFCTEVSTGKEQNI 80
Cdd:COG3401   298 YYYRVTAVDAAGnESAPSNVVSVTTDLTP--PAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVYRSTSGGGTYTKI 373

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175  81 --EVDGLSYKLEGLKKFTEYTLRFLAYNRYGP-GVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSW-----LPPPS 152
Cdd:COG3401   374 aeTVTTTSYTDTGLTPGTTYYYKVTAVDAAGNeSAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAaasaaSNPGV 453

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 153 GTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPeNDLDESQVPDQ 232
Cdd:COG3401   454 SAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVG-GAPDGTPNVTG 532

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958740175 233 PSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAF 303
Cdd:COG3401   533 ASPVTVGASTGDVLITDLVSLTTSASSSVSGAGLGSGNLYLITTLGGSLLTTTSTNTNDVAGVHGGTLLVL 603
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 230-309 9.59e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.08  E-value: 9.59e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175  230 PDQPSSLHVRPQT-NCIIMSWTPPLNPNIV--VRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNA 306
Cdd:smart00060   1 PSPPSNLRVTDVTsTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 1958740175  307 GEG 309
Cdd:smart00060  81 GEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 350-443 1.35e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.97  E-value: 1.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 350 PPVGVQAVALTHEAVRVSWadnsVPKNQKTSDVRLYTVRWR-TSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTK 428
Cdd:cd00063     3 PPTNLRVTDVTSTSVTLSW----TPPEDDGGPITGYVVEYReKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 1958740175 429 NRRSSTWSMTAHATT 443
Cdd:cd00063    79 GGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 230-318 1.23e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.27  E-value: 1.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 230 PDQPSSLHVRPQT-NCIIMSWTPPLNPNIVVRGYIIGY-GVGSPYAETVRV-DSKQRYYSIERLESSSHYVISLKAFNNA 306
Cdd:cd00063     1 PSPPTNLRVTDVTsTSVTLSWTPPEDDGGPITGYVVEYrEKGSGDWKEVEVtPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|..
gi 1958740175 307 GEGVPLYESATT 318
Cdd:cd00063    81 GESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
231-311 2.41e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 49.34  E-value: 2.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 231 DQPSSLHVRPQT-NCIIMSWTPPLNPNIVVRGYIIGYGV--GSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAG 307
Cdd:pfam00041   1 SAPSNLTVTDVTsTSLTVSWTPPPDGNGPITGYEVEYRPknSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                  ....
gi 1958740175 308 EGVP 311
Cdd:pfam00041  81 EGPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 350-433 1.08e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 1.08e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175  350 PPVGVQAVALTHEAVRVSWadNSVPKNQKTSDVRLYTVRWRTSFSASAKYkSEDTTSLSYTATGLKPNTMYEFSVMVTKN 429
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSW--EPPPDDGITGYIVGYRVEYREEGSEWKEV-NVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                   ....
gi 1958740175  430 RRSS 433
Cdd:smart00060  80 AGEG 83
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 646-931 9.41e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 49.69  E-value: 9.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 646 KGSQKDLRPPDlwihhEEMEMKNIEKPAGtdPAGRGSPiqscqdltPVSHSQSESQMGSKSASHSGQDTEEAGSSMSTLE 725
Cdd:PTZ00449  490 KKSKKKLAPIE-----EEDSDKHDEPPEG--PEASGLP--------PKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKE 554

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 726 RSLAARratrtklmiPMEAQSNNPavvSAIPVPTlESAQYPGILPSPTcGYPHPQFTLRPVpfptlsvdrgfgagrsqsV 805
Cdd:PTZ00449  555 GEVGKK---------PGPAKEHKP---SKIPTLS-KKPEFPKDPKHPK-DPEEPKKPKRPR------------------S 602

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 806 SEGPTAQQQPMLP-----PAQPEHPSSEEAPSRTIPTAcvRPTHPLRSFANPLLPPPMSAIEPKVPYTPLL--------- 871
Cdd:PTZ00449  603 AQRPTRPKSPKLPelldiPKSPKRPESPKSPKRPPPPQ--RPSSPERPEGPKIIKSPKPPKSPKPPFDPKFkekfyddyl 680

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 872 -----SQPGPTLPKTHVKTASLGLAGKARSPLLPVSV-----PTAPEVSEESHKPTEDPASvyEQDDLSE 931
Cdd:PTZ00449  681 daaakSKETKTTVVLDESFESILKETLPETPGTPFTTprplpPKLPRDEEFPFEPIGDPDA--EQPDDIE 748
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
126-558 1.32e-05

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 49.17  E-value: 1.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 126 PSAPPQNV----SLEVVNS----RSIKVSWLPPPSGTqngfitGYKIRHRK--TTRRGEMETLEPNnlwYLFTGLEKGsQ 195
Cdd:COG4733   529 PQWPPVNVttseSLSVVAQgtavTTLTVSWDAPAGAV------AYEVEWRRddGNWVSVPRTSGTS---FEVPGIYAG-D 598

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 196 YSFQVSAmtVNGTGPPSNWYTAETPENDLDESqVPDQPSSLHVRPQTNCIIMSWTPPLNPNivVRGYIIGYGVGSPY--A 273
Cdd:COG4733   599 YEVRVRA--INALGVSSAWAASSETTVTGKTA-PPPAPTGLTATGGLGGITLSWSFPVDAD--TLRTEIRYSTTGDWasA 673

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 274 ETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATT--------RSITDPTDPVDYYPLLDDF--PTSGPD 343
Cdd:COG4733   674 TVAQALYPGNTYTLAGLKAGQTYYYRARAVDRSGNVSAWWVSGQAsadaagilDAITGQILETELGQELDAIiqNATVAE 753

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 344 VSTPMLPPVGVQAVALTHEAVRVSWADNSVPKNQKTSDVRLYTVRWRTS-FSASAKYKSEDTTSLSYTATGLKPNTMYEF 422
Cdd:COG4733   754 VVAATVTDVTAQIDTAVLFAGVATAAAIGAEARVAATVAESATAAAATGtAADAAGDASGGVTAGTSGTTGAGDTAASTT 833

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 423 SVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIME 502
Cdd:COG4733   834 RVAAAVVLAGVVVYGDAIIESGNTGDIVATGDIASAAAGAVATTVSGTTAADVSAVADSTAASLTAIVIAATTIIDAIGD 913

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958740175 503 TISGDRlthQIMDLSLDTMYYFRIQARNAKGVGPLSDPILFRTLKVEHPDKMANDQ 558
Cdd:COG4733   914 GTTREP---AGDIGASGGAQGFAVTIVGSFDGAGAVATVDAGQSVVDGVGTAVEAA 966
fn3 pfam00041
Fibronectin type III domain;
350-424 1.73e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.94  E-value: 1.73e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958740175 350 PPVGVQAVALTHEAVRVSWAdnsvPKNQKTSDVRLYTVRWRTSFSASA-KYKSEDTTSLSYTATGLKPNTMYEFSV 424
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWT----PPPDGNGPITGYEVEYRPKNSGEPwNEITVPGTTTSVTLTGLKPGTEYEVRV 73
PHA03247 PHA03247
large tegument protein UL36; Provisional
 692-920 2.26e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 2.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175  692 PVSHSQSESQMGSKSASHSGQDTEEAGSSMSTLERSlAARRATRTKLMIPMEAQSNNPAVVSAIPVPTLESAQYPGILPS 771
Cdd:PHA03247  2631 PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRR-ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPE 2709

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175  772 PTcgyPHPQFTLRPVPfptlsvdrgFGAGRSQSVSEGPTAQQQPMLPPAQPEHPSSEEAPSR-TIPTACVRPTHPLRSFA 850
Cdd:PHA03247  2710 PA---PHALVSATPLP---------PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARpPTTAGPPAPAPPAAPAA 2777

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958740175  851 NP---LLPPPMSAIEPKVPYTPLLSQPGPTLPKTHVKTASLGLAGKARSPLLP--VSVPTAPEVSEESHKPTEDP 920
Cdd:PHA03247  2778 GPprrLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPptSAQPTAPPPPPGPPPPSLPL 2852
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
344-533 2.41e-04

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 44.94  E-value: 2.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 344 VSTPMLPPVGVQAVALTheaVRVSWADNSVpkNQKTSDVRLyTVRWRTS---FSASAKYKSED--------TTSLSYTAT 412
Cdd:COG4733   519 IDAGAFDDVPPQWPPVN---VTTSESLSVV--AQGTAVTTL-TVSWDAPagaVAYEVEWRRDDgnwvsvprTSGTSFEVP 592

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 413 GLKPNTmYEFSVM-VTKNRRSSTWSMTAHAT-TYEAAPTSAPKDLTVitrEGKPRAVIVSWQPPLEANgkITAYILFYTl 490
Cdd:COG4733   593 GIYAGD-YEVRVRaINALGVSSAWAASSETTvTGKTAPPPAPTGLTA---TGGLGGITLSWSFPVDAD--TLRTEIRYS- 665

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1958740175 491 dkniPIDDW---IMETISGDRLTHQIMDLSLDTMYYFRIQARNAKG 533
Cdd:COG4733   666 ----TTGDWasaTVAQALYPGNTYTLAGLKAGQTYYYRARAVDRSG 707
PHA03247 PHA03247
large tegument protein UL36; Provisional
 672-922 3.14e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 3.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175  672 PAGTDPAGRGSPIQSCQDLTPVSHSQSESQMGSKSASHSgqdTEEAGSSMSTLERSLAARRATRTKLMIPMEAQSNNPAV 751
Cdd:PHA03247  2734 ALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPP---AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA 2810

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175  752 VSAiPVPTLESAQYP-GILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGrsQSVSEGPTAQQQPMLPpAQPEHPS---- 826
Cdd:PHA03247  2811 VLA-PAAALPPAASPaGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPG--GDVRRRPPSRSPAAKP-AAPARPPvrrl 2886

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175  827 SEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPllsQPGPT--------LPKTHVKTASLGLAGKARSPL 898
Cdd:PHA03247  2887 ARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQP---QPPPPppprpqppLAPTTDPAGAGEPSGAVPQPW 2963

                          250       260
                   ....*....|....*....|....*...
gi 1958740175  899 LPVSVPTAPEVSE----ESHKPTEDPAS 922
Cdd:PHA03247  2964 LGALVPGRVAVPRfrvpQPAPSREAPAS 2991
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 129-220 4.04e-04

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 40.79  E-value: 4.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 129 PPQnVSLEVVNsRSIKVSWLPPPSGTQNGFIT-------GYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVS 201
Cdd:pfam09294   5 PPE-VELEVEG-GSLNVTVKDPETREGKNLSLrdlygslQYRVSYWKNSSNGEKKNTTSTNSFVVLSDLEPGTTYCVSVQ 82

                          90       100
                  ....*....|....*....|.
gi 1958740175 202 A--MTVNGTGPPSNWYTAETP 220
Cdd:pfam09294  83 AfsPLDNKSSQRSPPQCIRTT 103
Pur_ac_phosph_N pfam16656
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ...
 364-443 1.12e-03

Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.


Pssm-ID: 465220 [Multi-domain]  Cd Length: 93  Bit Score: 38.93  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 364 VRVSWADNSVPKNQKtsdVRLYTVRWRTSFSASAK------YKSEDTTSLSYTATGLKPNTMYEFSVMVTknrrSSTWSM 437
Cdd:pfam16656  15 MTVSWVTPSAVTSPV---VQYGTSSSALTSTATATsstyttGDGGTGYIHRATLTGLEPGTTYYYRVGDD----NGGWSE 87


                  ....*.
gi 1958740175 438 TAHATT 443
Cdd:pfam16656  88 VYSFTT 93
Pur_ac_phosph_N pfam16656
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ...
 130-219 1.98e-03

Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.


Pssm-ID: 465220 [Multi-domain]  Cd Length: 93  Bit Score: 38.54  E-value: 1.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 130 PQNVSLEVVN-SRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLW------YLFTGLEKGSQYSFQVSA 202
Cdd:pfam16656   1 PEQVHLSLTGdSTSMTVSWVTPSAVTSPVVQYGTSSSALTSTATATSSTYTTGDGGtgyihrATLTGLEPGTTYYYRVGD 80

                          90
                  ....*....|....*..
gi 1958740175 203 mtvnGTGPPSNWYTAET 219
Cdd:pfam16656  81 ----DNGGWSEVYSFTT 93
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 742-882 2.20e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 41.95  E-value: 2.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 742 MEAQSNNPAvvsaiPVPTLESAQYPGILPSPtcgyPHPQFTLRPVPFPTLSVDRGFGAGRSQSVSEG--PTAQQQPMLPP 819
Cdd:pfam09770 203 MRAQAKKPA-----QQPAPAPAQPPAAPPAQ----QAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGhpVTILQRPQSPQ 273

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958740175 820 AQPEHPSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPmsAIEPKVPYTPLLSQPGPTLPKTH 882
Cdd:pfam09770 274 PDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSA--ARVGYPQNPQPGVQPAPAHQAHR 334
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
2-117 2.48e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 41.85  E-value: 2.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175   2 YTFRVVAYNEWG-PGESSQPIKVATQPELQVPGPVENLHAvSASPTSILITWEPPAYAngPVQGYRLFCTEVSTGKEQNI 80
Cdd:COG4733   599 YEVRVRAINALGvSSAWAASSETTVTGKTAPPPAPTGLTA-TGGLGGITLSWSFPVDA--DTLRTEIRYSTTGDWASATV 675

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1958740175  81 EVD---GLSYKLEGLKKFTEYTLRFLAYNRYG-------PGVSTDDI 117
Cdd:COG4733   676 AQAlypGNTYTLAGLKAGQTYYYRARAVDRSGnvsawwvSGQASADA 722
PHA03247 PHA03247
large tegument protein UL36; Provisional
 676-907 3.20e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 3.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175  676 DPAGRGSPIQSCQDLTPVSHSQSEsqmGSKSASHSGQDTEEAGSSMSTLERSLAARRATRTKlmipMEAQSNNPAVVSAI 755
Cdd:PHA03247  2607 DPRGPAPPSPLPPDTHAPDPPPPS---PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPR----RARRLGRAAQASSP 2679

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175  756 PVPTLESAQYPGILPSPTCGYPHPQ-FTLRPVPFPTLS-VDRGFGAGRSQSVSEGPTAQQQPMLPPAQPEHPSSEEAPSR 833
Cdd:PHA03247  2680 PQRPRRRAARPTVGSLTSLADPPPPpPTPEPAPHALVSaTPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPAR 2759

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958740175  834 -TIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTHVKTASLGLAGKARSPLLPVSVPTAP 907
Cdd:PHA03247  2760 pPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSA 2834
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
46-223 3.23e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 41.47  E-value: 3.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175  46 TSILITWEPPAYANG-PVQGYRlfctevSTGKEQNI-EVDGLSYKLEGLKKfTEYTLRFLAYNRYG---PGVSTDDITVV 120
Cdd:COG4733   552 TTLTVSWDAPAGAVAyEVEWRR------DDGNWVSVpRTSGTSFEVPGIYA-GDYEVRVRAINALGvssAWAASSETTVT 624

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 121 TLSDVPSAPpqnVSLEVVNS-RSIKVSWLPPPsgtqNGFITGYKIRHRKTTRRGEME---TLEPNNLWYLfTGLEKGSQY 196
Cdd:COG4733   625 GKTAPPPAP---TGLTATGGlGGITLSWSFPV----DADTLRTEIRYSTTGDWASATvaqALYPGNTYTL-AGLKAGQTY 696

                         170       180
                  ....*....|....*....|....*..
gi 1958740175 197 SFQVSAmtVNGTGPPSNWYTAETPEND 223
Cdd:COG4733   697 YYRARA--VDRSGNVSAWWVSGQASAD 721
PHA03247 PHA03247
large tegument protein UL36; Provisional
 741-932 4.88e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 4.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175  741 PMEAQSNNPAVVSAIPVPTLESAQYPGILPSPTCGYPhpqftlrPVPFPTLSVDRGFGAGRSQSVSEGPTAQQQPMLPPA 820
Cdd:PHA03247  2705 PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAP-------PAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAA 2777

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175  821 QPE-----------HPSSEEAPS------RTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTHV 883
Cdd:PHA03247  2778 GPPrrltrpavaslSESRESLPSpwdpadPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVA 2857

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1958740175  884 KTASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDPASVYEQDDLSEQ 932
Cdd:PHA03247  2858 PGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPE 2906
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
715-943 6.00e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.24  E-value: 6.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 715 EEAGSSMsTLERSLAARR------ATRTKLMIPMEAQSNNPAVVSAIPVPTLESAQYPGILPSPTCGYPHPQF---TLRP 785
Cdd:PRK12323  349 EYAGFTM-TLLRMLAFRPgqsgggAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAaapARRS 427

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 786 VPFPTLSVDRGFGAGRSQSVSEgPTAQQQPMLPPAQPEHPSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKV 865
Cdd:PRK12323  428 PAPEALAAARQASARGPGGAPA-PAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEF 506

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 866 PYTPL--------------LSQPGPTLPKTHVKTASlglAGKARSPLLPVSVPTAPEVSEESHKPTEDPASVYEQDDLSE 931
Cdd:PRK12323  507 ASPAPaqpdaapagwvaesIPDPATADPDDAFETLA---PAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPA 583

                         250
                  ....*....|....
gi 1958740175 932 QMASL--EGLMKQL 943
Cdd:PRK12323  584 LAARLpvRGLAQQL 597
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 669-907 9.05e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 9.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 669 IEKPAGTDPAGRGSPIQSCQ------DLTPVSHSQSESQMGSKSASHSGQDTEEAGSSMSTLERSLAARRATRTKLMIPM 742
Cdd:pfam03154 289 MQHPVPPQPFPLTPQSSQSQvppgpsPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPN 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 743 EAQSNNPAVVSAiPVPTlesaQYPGILPSPTCGYP-------HPQfTLRPVPFPTLSVDRGFGAGRSQSvsegPTAQQQP 815
Cdd:pfam03154 369 PQSHKHPPHLSG-PSPF----QMNSNLPPPPALKPlsslsthHPP-SAHPPPLQLMPQSQQLPPPPAQP----PVLTQSQ 438

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958740175 816 MLPPAQPEHPSSeeAPSRTIPTACVRPTHPLRSFANPLLPPP----------MSAIEPKVPYTPLLSQPGP-----TLPK 880
Cdd:pfam03154 439 SLPPPAASHPPT--SGLHQVPSQSPFPQHPFVPGGPPPITPPsgpptstssaMPGIQPPSSASVSSSGPVPaavscPLPP 516

                         250       260
                  ....*....|....*....|....*..
gi 1958740175 881 THVKTASLGLAGKARSPLLPVSVPTAP 907
Cdd:pfam03154 517 VQIKEEALDEAEEPESPPPPPRSPSPE 543
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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