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Conserved domains on  [gi|1958734632|ref|XP_038952374|]
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junctional cadherin 5-associated protein isoform X1 [Rattus norvegicus]

Protein Classification

JCAD domain-containing protein( domain architecture ID 12173170)

JCAD domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
JCAD pfam15351
Junctional protein associated with coronary artery disease; JCAD is a component of ...
 1-1319 0e+00

Junctional protein associated with coronary artery disease; JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. The cell-cell or adherens junction is an adhesion complex that plays a crucial role in the organization and function of epithelial and endothelial cellular sheets. These junctions join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. The junctions also mediate both cell adhesion and cell-signalling. JCAD localizes close to the apical membrane in epithelial cells. This family is found in eukaryotes.


:

Pssm-ID: 434658  Cd Length: 1358  Bit Score: 1800.46  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632    1 MYSVEDLLISHGYKPARDAPVPREDKSERCRSRRTGPQAGQGLLNGYKDGPTAHAHSRTALGTGHVSNSEKHSSKPRGHQ 80
Cdd:pfam15351    1 MYSVEDLLISHGYKLSRDLPAPREDRYEGRQQARTRTRAGHGLLNGCEDGPAALAHSKKSLGKGHVSDSESRRRGPRGHG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632   81 EYQSSS-SRTPEAGFLSQPSLAWSSQPQSGRDHIYWSRGQQEGSGSLCPRDQEEVEVRRMAQAHSLPIHVRESPWEVARR 159
Cdd:pfam15351   81 EPQSTSaSRASEAGFYNQPVLAWSSQPQTGKDHAYWRRRGQEVSGLLGPRDREDLEVRGMAQAHSLPVHVREGPWEVGGR 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  160 TEHVMKNALWEAELRMPTPAKWQDMTLESWKQPRKLGRQASDGDGQKrsqeRFEDLYQFVHGEHMLTSQNRKKSQSLPRA 239
Cdd:pfam15351  161 TEHVMKKAVWEEELRMSGPAKWQNVSLESWNQPRKLGRQMSDGDGEK----LFQDLYPFIQGEHVLTSQNKGKSQSLPRV 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  240 LSPKSLNFTEIPVPLHDGHITGVPKVPPYPPSCPPPLEPTRNLEKTSSSGPFPRPKFGKPLKTPCHGSQPQPRG---EGG 316
Cdd:pfam15351  237 LSPESLSCMEIPIPLNDGHLPGVPKMPPYPPNCAPNLESTRNPEKGGSSAPLPRPKFGRPLKPPSYESHQQSRGgveNSD 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  317 FQDHQHRDPRGCHPTRSKDPGHELGMLDTGLEPPVYVPPPSYRSPPQHIPNPYLEDPIPRHVSSSQSQQQQLPEKPEADC 396
Cdd:pfam15351  317 YQDSQQADLCVSYLTRTSDPRQELCAPDPGLEPPVYVPPPSYRSPPQHIPNPYLEDAVPRHVSGGHSQQQHPTEKPGASC 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  397 LLPSGSLAARDLYNAMpGSPPPGPPPHPYPIATHGDSIQYIPFDDPRIRHIKLAQPPEFYEEARLEDTSYNSGFIATQEP 476
Cdd:pfam15351  397 QLPSGSLGTGNEYGAS-PRSPRGLPPHPRPVTAYDGSVQYIPFDDPRIRHIKLAQPQGFCEETKLDDKSYSSGPVTAQEP 475

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  477 ALGKRQYNDALSAPRGPILPPVNERGSAFAHSSPQWLQGQLPMASEPGGFPGQTEHHGMRGLTADVRDSK---VESHASS 553
Cdd:pfam15351  476 ARGEMQHDGAVLNPQSLTPPSGSERGPAFADPSPRWLWGQLPRDGENGGFPDQRDHCVVRGQWPDVRGSQhghAEGQVSS 555

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  554 PQPQSEGTCRTHTKLRKFETGIQSRKSSK-KSNATIFCLVSVPVKSESLVPDTDTNNNDLKLGADKNHGLYQGPALEEQS 632
Cdd:pfam15351  556 PSPQGESTCETQTKLKKFETGIQTKKSSKkKMNETIFCLVSIPVKSESHLPDTDTNNNDLKQSADKKNGLDKSGALQEQS 635

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  633 LLSMSSTDLELQALMGSMAWRRTSPRQVLGESE-DGQTDDPRTLHLIKPRELRASGSWPGHQYRDQQTQTSFPEDSKSSQ 711
Cdd:pfam15351  636 LLSMSSTDLELQALTGSMAGRTELQKQDLGEPEeDKQTNDLRFIHPAKHRELKYSGSWPGHQYRDQQTQTSFTEESKSSQ 715

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  712 LLPATKPGEASNAALTPTCPDDTASEVHLHAALASSDPSQKPSVPHLRGQMSLSPSRNSAFSRTSSTINQTSMPKGASGQ 791
Cdd:pfam15351  716 LLPAEKPGGSSNAAPTPKCLDPTASEAQTHTALASSDQNQRPSAPSLKGQMSLSPSSNSAFSRTSSSINQAPVPKAGQSQ 795

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  792 LPS------ANPVPKPEVVKGESTvGQCNSTQLFGQFLLKPVSRRPWDLISQLESFNKELQEEEESHGVSSGGDSEDSEA 865
Cdd:pfam15351  796 PCVdvrgrgASPVPRGEVVKGETT-GPCNSKQLFGQFLLKPVSRRPWDLISQLESFNKELQEEEESSSSSSGSSSEDSEA 874

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  866 E-QPEDCADSSAKTRG----HQETRREQRPAELALGEAGP-PGGRLGESQSRSKEPKPGHPCARSQALGPSQEEDSRGVP 939
Cdd:pfam15351  875 EwQPEDCADSRPKSPGfredSQEMRVEQQPRRLVPEDPVFrSGRVKSKSESWSEEPKPGHPCACPQSPGPSQVEDGRGEP 954

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  940 VQWGHGNLSAEQKSQEALNGMCERDISPRPVSRIA---PVDTQAASLFCLAEPRGSQELTKVNDALGSVELGRETPIRVD 1016
Cdd:pfam15351  955 FLSADGSLITEKRKQEVGNRINELAVSPGPVKRITssrSSDTKPVPPSYPAELREPQESQKLPDALSSVQLSKAAPPRAG 1034

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632 1017 NGGDTEVLPCvlPPLADRCRGLSTPNFPSLELTLGQEQRAYKSE-CQGLDNTVEVLPSESLQERAERILGIEVAVESLLP 1095
Cdd:pfam15351 1035 GGEERGTAVP--LSLASKSRGLSAPDLRSVGLTPGQEQSASKLDgSLGEASAIEIPPNESLQARAARILGIEVAVESLLP 1112

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632 1096 GARRTEQSQLPKPGTSACSPRSSREDSQPSSASPEDPTVATDAFYGRRKCGWTESPLFVGER-----APQAAVCSDVDGF 1170
Cdd:pfam15351 1113 GARRTGQSQPPEPDGSACSPESPREESVSSSAPPDGPTVSTDAFYGRRKCGWTESPLFVGERdsarrAPQASEHSGVDGV 1192

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632 1171 PTSQATSPEP-----------EKKKEAKPPFKSTLFHFMEKSTNVVGPEKRLRNSSNVIESSQGKLVSLPKRADSARLVR 1239
Cdd:pfam15351 1193 VPSQAPSPEPqpsplesksfeQKDVETKPPFRSTLFHFIERTPSVAGSEKRLRSTSKVIESLQEKLASPPRRADPDRLMR 1272

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632 1240 MREVNSLSQMRCLSSKSADSMEEPDPLKVIKSSAWPSEGLTSPSGKDQAWQAEYLPSVSQ-----NENGHPEVIREKMSD 1314
Cdd:pfam15351 1273 MKEVSSVSRMRLLSSRSADSGEEAEELKAERGQAGQPGGPVSLNGGDRARKAGHSLSVSKgiislEENGHPAAQREKNGD 1352


                   ....*
gi 1958734632 1315 QDLWC 1319
Cdd:pfam15351 1353 QDFWC 1357
 
Name Accession Description Interval E-value
JCAD pfam15351
Junctional protein associated with coronary artery disease; JCAD is a component of ...
 1-1319 0e+00

Junctional protein associated with coronary artery disease; JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. The cell-cell or adherens junction is an adhesion complex that plays a crucial role in the organization and function of epithelial and endothelial cellular sheets. These junctions join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. The junctions also mediate both cell adhesion and cell-signalling. JCAD localizes close to the apical membrane in epithelial cells. This family is found in eukaryotes.


Pssm-ID: 434658  Cd Length: 1358  Bit Score: 1800.46  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632    1 MYSVEDLLISHGYKPARDAPVPREDKSERCRSRRTGPQAGQGLLNGYKDGPTAHAHSRTALGTGHVSNSEKHSSKPRGHQ 80
Cdd:pfam15351    1 MYSVEDLLISHGYKLSRDLPAPREDRYEGRQQARTRTRAGHGLLNGCEDGPAALAHSKKSLGKGHVSDSESRRRGPRGHG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632   81 EYQSSS-SRTPEAGFLSQPSLAWSSQPQSGRDHIYWSRGQQEGSGSLCPRDQEEVEVRRMAQAHSLPIHVRESPWEVARR 159
Cdd:pfam15351   81 EPQSTSaSRASEAGFYNQPVLAWSSQPQTGKDHAYWRRRGQEVSGLLGPRDREDLEVRGMAQAHSLPVHVREGPWEVGGR 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  160 TEHVMKNALWEAELRMPTPAKWQDMTLESWKQPRKLGRQASDGDGQKrsqeRFEDLYQFVHGEHMLTSQNRKKSQSLPRA 239
Cdd:pfam15351  161 TEHVMKKAVWEEELRMSGPAKWQNVSLESWNQPRKLGRQMSDGDGEK----LFQDLYPFIQGEHVLTSQNKGKSQSLPRV 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  240 LSPKSLNFTEIPVPLHDGHITGVPKVPPYPPSCPPPLEPTRNLEKTSSSGPFPRPKFGKPLKTPCHGSQPQPRG---EGG 316
Cdd:pfam15351  237 LSPESLSCMEIPIPLNDGHLPGVPKMPPYPPNCAPNLESTRNPEKGGSSAPLPRPKFGRPLKPPSYESHQQSRGgveNSD 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  317 FQDHQHRDPRGCHPTRSKDPGHELGMLDTGLEPPVYVPPPSYRSPPQHIPNPYLEDPIPRHVSSSQSQQQQLPEKPEADC 396
Cdd:pfam15351  317 YQDSQQADLCVSYLTRTSDPRQELCAPDPGLEPPVYVPPPSYRSPPQHIPNPYLEDAVPRHVSGGHSQQQHPTEKPGASC 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  397 LLPSGSLAARDLYNAMpGSPPPGPPPHPYPIATHGDSIQYIPFDDPRIRHIKLAQPPEFYEEARLEDTSYNSGFIATQEP 476
Cdd:pfam15351  397 QLPSGSLGTGNEYGAS-PRSPRGLPPHPRPVTAYDGSVQYIPFDDPRIRHIKLAQPQGFCEETKLDDKSYSSGPVTAQEP 475

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  477 ALGKRQYNDALSAPRGPILPPVNERGSAFAHSSPQWLQGQLPMASEPGGFPGQTEHHGMRGLTADVRDSK---VESHASS 553
Cdd:pfam15351  476 ARGEMQHDGAVLNPQSLTPPSGSERGPAFADPSPRWLWGQLPRDGENGGFPDQRDHCVVRGQWPDVRGSQhghAEGQVSS 555

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  554 PQPQSEGTCRTHTKLRKFETGIQSRKSSK-KSNATIFCLVSVPVKSESLVPDTDTNNNDLKLGADKNHGLYQGPALEEQS 632
Cdd:pfam15351  556 PSPQGESTCETQTKLKKFETGIQTKKSSKkKMNETIFCLVSIPVKSESHLPDTDTNNNDLKQSADKKNGLDKSGALQEQS 635

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  633 LLSMSSTDLELQALMGSMAWRRTSPRQVLGESE-DGQTDDPRTLHLIKPRELRASGSWPGHQYRDQQTQTSFPEDSKSSQ 711
Cdd:pfam15351  636 LLSMSSTDLELQALTGSMAGRTELQKQDLGEPEeDKQTNDLRFIHPAKHRELKYSGSWPGHQYRDQQTQTSFTEESKSSQ 715

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  712 LLPATKPGEASNAALTPTCPDDTASEVHLHAALASSDPSQKPSVPHLRGQMSLSPSRNSAFSRTSSTINQTSMPKGASGQ 791
Cdd:pfam15351  716 LLPAEKPGGSSNAAPTPKCLDPTASEAQTHTALASSDQNQRPSAPSLKGQMSLSPSSNSAFSRTSSSINQAPVPKAGQSQ 795

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  792 LPS------ANPVPKPEVVKGESTvGQCNSTQLFGQFLLKPVSRRPWDLISQLESFNKELQEEEESHGVSSGGDSEDSEA 865
Cdd:pfam15351  796 PCVdvrgrgASPVPRGEVVKGETT-GPCNSKQLFGQFLLKPVSRRPWDLISQLESFNKELQEEEESSSSSSGSSSEDSEA 874

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  866 E-QPEDCADSSAKTRG----HQETRREQRPAELALGEAGP-PGGRLGESQSRSKEPKPGHPCARSQALGPSQEEDSRGVP 939
Cdd:pfam15351  875 EwQPEDCADSRPKSPGfredSQEMRVEQQPRRLVPEDPVFrSGRVKSKSESWSEEPKPGHPCACPQSPGPSQVEDGRGEP 954

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  940 VQWGHGNLSAEQKSQEALNGMCERDISPRPVSRIA---PVDTQAASLFCLAEPRGSQELTKVNDALGSVELGRETPIRVD 1016
Cdd:pfam15351  955 FLSADGSLITEKRKQEVGNRINELAVSPGPVKRITssrSSDTKPVPPSYPAELREPQESQKLPDALSSVQLSKAAPPRAG 1034

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632 1017 NGGDTEVLPCvlPPLADRCRGLSTPNFPSLELTLGQEQRAYKSE-CQGLDNTVEVLPSESLQERAERILGIEVAVESLLP 1095
Cdd:pfam15351 1035 GGEERGTAVP--LSLASKSRGLSAPDLRSVGLTPGQEQSASKLDgSLGEASAIEIPPNESLQARAARILGIEVAVESLLP 1112

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632 1096 GARRTEQSQLPKPGTSACSPRSSREDSQPSSASPEDPTVATDAFYGRRKCGWTESPLFVGER-----APQAAVCSDVDGF 1170
Cdd:pfam15351 1113 GARRTGQSQPPEPDGSACSPESPREESVSSSAPPDGPTVSTDAFYGRRKCGWTESPLFVGERdsarrAPQASEHSGVDGV 1192

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632 1171 PTSQATSPEP-----------EKKKEAKPPFKSTLFHFMEKSTNVVGPEKRLRNSSNVIESSQGKLVSLPKRADSARLVR 1239
Cdd:pfam15351 1193 VPSQAPSPEPqpsplesksfeQKDVETKPPFRSTLFHFIERTPSVAGSEKRLRSTSKVIESLQEKLASPPRRADPDRLMR 1272

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632 1240 MREVNSLSQMRCLSSKSADSMEEPDPLKVIKSSAWPSEGLTSPSGKDQAWQAEYLPSVSQ-----NENGHPEVIREKMSD 1314
Cdd:pfam15351 1273 MKEVSSVSRMRLLSSRSADSGEEAEELKAERGQAGQPGGPVSLNGGDRARKAGHSLSVSKgiislEENGHPAAQREKNGD 1352


                   ....*
gi 1958734632 1315 QDLWC 1319
Cdd:pfam15351 1353 QDFWC 1357
 
Name Accession Description Interval E-value
JCAD pfam15351
Junctional protein associated with coronary artery disease; JCAD is a component of ...
 1-1319 0e+00

Junctional protein associated with coronary artery disease; JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. The cell-cell or adherens junction is an adhesion complex that plays a crucial role in the organization and function of epithelial and endothelial cellular sheets. These junctions join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. The junctions also mediate both cell adhesion and cell-signalling. JCAD localizes close to the apical membrane in epithelial cells. This family is found in eukaryotes.


Pssm-ID: 434658  Cd Length: 1358  Bit Score: 1800.46  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632    1 MYSVEDLLISHGYKPARDAPVPREDKSERCRSRRTGPQAGQGLLNGYKDGPTAHAHSRTALGTGHVSNSEKHSSKPRGHQ 80
Cdd:pfam15351    1 MYSVEDLLISHGYKLSRDLPAPREDRYEGRQQARTRTRAGHGLLNGCEDGPAALAHSKKSLGKGHVSDSESRRRGPRGHG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632   81 EYQSSS-SRTPEAGFLSQPSLAWSSQPQSGRDHIYWSRGQQEGSGSLCPRDQEEVEVRRMAQAHSLPIHVRESPWEVARR 159
Cdd:pfam15351   81 EPQSTSaSRASEAGFYNQPVLAWSSQPQTGKDHAYWRRRGQEVSGLLGPRDREDLEVRGMAQAHSLPVHVREGPWEVGGR 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  160 TEHVMKNALWEAELRMPTPAKWQDMTLESWKQPRKLGRQASDGDGQKrsqeRFEDLYQFVHGEHMLTSQNRKKSQSLPRA 239
Cdd:pfam15351  161 TEHVMKKAVWEEELRMSGPAKWQNVSLESWNQPRKLGRQMSDGDGEK----LFQDLYPFIQGEHVLTSQNKGKSQSLPRV 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  240 LSPKSLNFTEIPVPLHDGHITGVPKVPPYPPSCPPPLEPTRNLEKTSSSGPFPRPKFGKPLKTPCHGSQPQPRG---EGG 316
Cdd:pfam15351  237 LSPESLSCMEIPIPLNDGHLPGVPKMPPYPPNCAPNLESTRNPEKGGSSAPLPRPKFGRPLKPPSYESHQQSRGgveNSD 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  317 FQDHQHRDPRGCHPTRSKDPGHELGMLDTGLEPPVYVPPPSYRSPPQHIPNPYLEDPIPRHVSSSQSQQQQLPEKPEADC 396
Cdd:pfam15351  317 YQDSQQADLCVSYLTRTSDPRQELCAPDPGLEPPVYVPPPSYRSPPQHIPNPYLEDAVPRHVSGGHSQQQHPTEKPGASC 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  397 LLPSGSLAARDLYNAMpGSPPPGPPPHPYPIATHGDSIQYIPFDDPRIRHIKLAQPPEFYEEARLEDTSYNSGFIATQEP 476
Cdd:pfam15351  397 QLPSGSLGTGNEYGAS-PRSPRGLPPHPRPVTAYDGSVQYIPFDDPRIRHIKLAQPQGFCEETKLDDKSYSSGPVTAQEP 475

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  477 ALGKRQYNDALSAPRGPILPPVNERGSAFAHSSPQWLQGQLPMASEPGGFPGQTEHHGMRGLTADVRDSK---VESHASS 553
Cdd:pfam15351  476 ARGEMQHDGAVLNPQSLTPPSGSERGPAFADPSPRWLWGQLPRDGENGGFPDQRDHCVVRGQWPDVRGSQhghAEGQVSS 555

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  554 PQPQSEGTCRTHTKLRKFETGIQSRKSSK-KSNATIFCLVSVPVKSESLVPDTDTNNNDLKLGADKNHGLYQGPALEEQS 632
Cdd:pfam15351  556 PSPQGESTCETQTKLKKFETGIQTKKSSKkKMNETIFCLVSIPVKSESHLPDTDTNNNDLKQSADKKNGLDKSGALQEQS 635

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  633 LLSMSSTDLELQALMGSMAWRRTSPRQVLGESE-DGQTDDPRTLHLIKPRELRASGSWPGHQYRDQQTQTSFPEDSKSSQ 711
Cdd:pfam15351  636 LLSMSSTDLELQALTGSMAGRTELQKQDLGEPEeDKQTNDLRFIHPAKHRELKYSGSWPGHQYRDQQTQTSFTEESKSSQ 715

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  712 LLPATKPGEASNAALTPTCPDDTASEVHLHAALASSDPSQKPSVPHLRGQMSLSPSRNSAFSRTSSTINQTSMPKGASGQ 791
Cdd:pfam15351  716 LLPAEKPGGSSNAAPTPKCLDPTASEAQTHTALASSDQNQRPSAPSLKGQMSLSPSSNSAFSRTSSSINQAPVPKAGQSQ 795

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  792 LPS------ANPVPKPEVVKGESTvGQCNSTQLFGQFLLKPVSRRPWDLISQLESFNKELQEEEESHGVSSGGDSEDSEA 865
Cdd:pfam15351  796 PCVdvrgrgASPVPRGEVVKGETT-GPCNSKQLFGQFLLKPVSRRPWDLISQLESFNKELQEEEESSSSSSGSSSEDSEA 874

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  866 E-QPEDCADSSAKTRG----HQETRREQRPAELALGEAGP-PGGRLGESQSRSKEPKPGHPCARSQALGPSQEEDSRGVP 939
Cdd:pfam15351  875 EwQPEDCADSRPKSPGfredSQEMRVEQQPRRLVPEDPVFrSGRVKSKSESWSEEPKPGHPCACPQSPGPSQVEDGRGEP 954

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632  940 VQWGHGNLSAEQKSQEALNGMCERDISPRPVSRIA---PVDTQAASLFCLAEPRGSQELTKVNDALGSVELGRETPIRVD 1016
Cdd:pfam15351  955 FLSADGSLITEKRKQEVGNRINELAVSPGPVKRITssrSSDTKPVPPSYPAELREPQESQKLPDALSSVQLSKAAPPRAG 1034

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632 1017 NGGDTEVLPCvlPPLADRCRGLSTPNFPSLELTLGQEQRAYKSE-CQGLDNTVEVLPSESLQERAERILGIEVAVESLLP 1095
Cdd:pfam15351 1035 GGEERGTAVP--LSLASKSRGLSAPDLRSVGLTPGQEQSASKLDgSLGEASAIEIPPNESLQARAARILGIEVAVESLLP 1112

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632 1096 GARRTEQSQLPKPGTSACSPRSSREDSQPSSASPEDPTVATDAFYGRRKCGWTESPLFVGER-----APQAAVCSDVDGF 1170
Cdd:pfam15351 1113 GARRTGQSQPPEPDGSACSPESPREESVSSSAPPDGPTVSTDAFYGRRKCGWTESPLFVGERdsarrAPQASEHSGVDGV 1192

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632 1171 PTSQATSPEP-----------EKKKEAKPPFKSTLFHFMEKSTNVVGPEKRLRNSSNVIESSQGKLVSLPKRADSARLVR 1239
Cdd:pfam15351 1193 VPSQAPSPEPqpsplesksfeQKDVETKPPFRSTLFHFIERTPSVAGSEKRLRSTSKVIESLQEKLASPPRRADPDRLMR 1272

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734632 1240 MREVNSLSQMRCLSSKSADSMEEPDPLKVIKSSAWPSEGLTSPSGKDQAWQAEYLPSVSQ-----NENGHPEVIREKMSD 1314
Cdd:pfam15351 1273 MKEVSSVSRMRLLSSRSADSGEEAEELKAERGQAGQPGGPVSLNGGDRARKAGHSLSVSKgiislEENGHPAAQREKNGD 1352


                   ....*
gi 1958734632 1315 QDLWC 1319
Cdd:pfam15351 1353 QDFWC 1357
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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