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Conserved domains on  [gi|1958707235|ref|XP_038951699|]
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WD repeat-containing protein 37 isoform X3 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
147-323 1.12e-23

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.99  E-value: 1.12e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958707235 147 QLVKEYIGHRDGIWDVSVARTQPIVLgTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:COG2319   195 KLLRTLTGHTGAVRSVAFSPDGKLLA-SGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958707235 227 RyvvqLPTPQPVADTSQQISGEDEIECSDkdepdlDGDV----SSDcPTVRV-------PLTSLKSHQGVVIAADWLVGG 295
Cdd:COG2319   274 D----LATGELLRTLTGHSGGVNSVAFSP------DGKLlasgSDD-GTVRLwdlatgkLLRTLTGHTGAVRSVAFSPDG 342

                         170       180
                  ....*....|....*....|....*...
gi 1958707235 296 KQVVTASWDRTANLYDVETSELVHSLTA 323
Cdd:COG2319   343 KTLASGSDDGTVRLWDLATGELLRTLTG 370
DivIVA super family cl34642
Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle ...
 64-91 5.29e-03

Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG3599:

Pssm-ID: 442818 [Multi-domain]  Cd Length: 125  Bit Score: 36.37  E-value: 5.29e-03
                          10        20
                  ....*....|....*....|....*...
gi 1958707235  64 QIEREFENLYIENLELRREIDSLNERLA 91
Cdd:COG3599    31 EVAEDYERLIRENKELKEKLEELEEELE 58
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
147-323 1.12e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.99  E-value: 1.12e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958707235 147 QLVKEYIGHRDGIWDVSVARTQPIVLgTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:COG2319   195 KLLRTLTGHTGAVRSVAFSPDGKLLA-SGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958707235 227 RyvvqLPTPQPVADTSQQISGEDEIECSDkdepdlDGDV----SSDcPTVRV-------PLTSLKSHQGVVIAADWLVGG 295
Cdd:COG2319   274 D----LATGELLRTLTGHSGGVNSVAFSP------DGKLlasgSDD-GTVRLwdlatgkLLRTLTGHTGAVRSVAFSPDG 342

                         170       180
                  ....*....|....*....|....*...
gi 1958707235 296 KQVVTASWDRTANLYDVETSELVHSLTA 323
Cdd:COG2319   343 KTLASGSDDGTVRLWDLATGELLRTLTG 370
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 147-323 2.39e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.71  E-value: 2.39e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958707235 147 QLVKEYIGHRDGIWDVSVARTQPIVLGtASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:cd00200    84 ECVRTLTGHTSYVSSVAFSPDGRILSS-SSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958707235 227 RyvvqLPTPQPVadtsQQISG-EDEIECSDKDEPDLDGDVSSDCPTVRV-------PLTSLKSHQGVVIAADWLVGGKQV 298
Cdd:cd00200   163 D----LRTGKCV----ATLTGhTGEVNSVAFSPDGEKLLSSSSDGTIKLwdlstgkCLGTLRGHENGVNSVAFSPDGYLL 234

                         170       180
                  ....*....|....*....|....*
gi 1958707235 299 VTASWDRTANLYDVETSELVHSLTA 323
Cdd:cd00200   235 ASGSEDGTIRVWDLRTGECVQTLSG 259
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 188-226 3.62e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 3.62e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958707235  188 TGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
189-226 1.09e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.09e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958707235 189 GKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
DivIVA COG3599
Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle ...
 64-91 5.29e-03

Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442818 [Multi-domain]  Cd Length: 125  Bit Score: 36.37  E-value: 5.29e-03
                          10        20
                  ....*....|....*....|....*...
gi 1958707235  64 QIEREFENLYIENLELRREIDSLNERLA 91
Cdd:COG3599    31 EVAEDYERLIRENKELKEKLEELEEELE 58
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
147-323 1.12e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.99  E-value: 1.12e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958707235 147 QLVKEYIGHRDGIWDVSVARTQPIVLgTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:COG2319   195 KLLRTLTGHTGAVRSVAFSPDGKLLA-SGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958707235 227 RyvvqLPTPQPVADTSQQISGEDEIECSDkdepdlDGDV----SSDcPTVRV-------PLTSLKSHQGVVIAADWLVGG 295
Cdd:COG2319   274 D----LATGELLRTLTGHSGGVNSVAFSP------DGKLlasgSDD-GTVRLwdlatgkLLRTLTGHTGAVRSVAFSPDG 342

                         170       180
                  ....*....|....*....|....*...
gi 1958707235 296 KQVVTASWDRTANLYDVETSELVHSLTA 323
Cdd:COG2319   343 KTLASGSDDGTVRLWDLATGELLRTLTG 370
WD40 COG2319
WD40 repeat [General function prediction only];
147-314 1.12e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.29  E-value: 1.12e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958707235 147 QLVKEYIGHRDGIWDVSVARTQPIVLgTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:COG2319   237 KLLRTLTGHSGSVRSVAFSPDGRLLA-SGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958707235 227 RyvvqLPTPQPVADTSQQISGEDEIECSDkdepdlDGD---VSSDCPTVRV-------PLTSLKSHQGVVIAADWLVGGK 296
Cdd:COG2319   316 D----LATGKLLRTLTGHTGAVRSVAFSP------DGKtlaSGSDDGTVRLwdlatgeLLRTLTGHTGAVTSVAFSPDGR 385

                         170
                  ....*....|....*...
gi 1958707235 297 QVVTASWDRTANLYDVET 314
Cdd:COG2319   386 TLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
147-323 1.35e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.90  E-value: 1.35e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958707235 147 QLVKEYIGHRDGIWDVSVART-QPIVlgTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHI 225
Cdd:COG2319   153 KLLRTLTGHSGAVTSVAFSPDgKLLA--SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRL 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958707235 226 WRyvvqLPTPQPVADTSQQISGEDEIECSDkdepdlDGD---VSSDCPTVRV-------PLTSLKSHQGVVIAADWLVGG 295
Cdd:COG2319   231 WD----LATGKLLRTLTGHSGSVRSVAFSP------DGRllaSGSADGTVRLwdlatgeLLRTLTGHSGGVNSVAFSPDG 300

                         170       180
                  ....*....|....*....|....*...
gi 1958707235 296 KQVVTASWDRTANLYDVETSELVHSLTA 323
Cdd:COG2319   301 KLLASGSDDGTVRLWDLATGKLLRTLTG 328
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 147-323 2.39e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.71  E-value: 2.39e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958707235 147 QLVKEYIGHRDGIWDVSVARTQPIVLGtASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:cd00200    84 ECVRTLTGHTSYVSSVAFSPDGRILSS-SSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958707235 227 RyvvqLPTPQPVadtsQQISG-EDEIECSDKDEPDLDGDVSSDCPTVRV-------PLTSLKSHQGVVIAADWLVGGKQV 298
Cdd:cd00200   163 D----LRTGKCV----ATLTGhTGEVNSVAFSPDGEKLLSSSSDGTIKLwdlstgkCLGTLRGHENGVNSVAFSPDGYLL 234

                         170       180
                  ....*....|....*....|....*
gi 1958707235 299 VTASWDRTANLYDVETSELVHSLTA 323
Cdd:cd00200   235 ASGSEDGTIRVWDLRTGECVQTLSG 259
WD40 COG2319
WD40 repeat [General function prediction only];
147-322 2.63e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.13  E-value: 2.63e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958707235 147 QLVKEYIGHRDGIWDVSVARTQPIVLgTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLA-SGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958707235 227 RyvvqLPTPQPVADTSQQISGEDEIECSDkdepdlDGD---VSSDCPTVRV-------PLTSLKSHQGVVIAADWLVGGK 296
Cdd:COG2319   190 D----LATGKLLRTLTGHTGAVRSVAFSP------DGKllaSGSADGTVRLwdlatgkLLRTLTGHSGSVRSVAFSPDGR 259

                         170       180
                  ....*....|....*....|....*.
gi 1958707235 297 QVVTASWDRTANLYDVETSELVHSLT 322
Cdd:COG2319   260 LLASGSADGTVRLWDLATGELLRTLT 285
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 128-323 2.07e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.01  E-value: 2.07e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958707235 128 ASTSKIVSSFKTTTSRAICQLVkeyiGHRDGIWDVS-VARTQPIVlgTASADHTALLWSIETGKCLVKYAGHVGSVNSIK 206
Cdd:cd00200    27 GSGDGTIKVWDLETGELLRTLK----GHTGPVRDVAaSADGTYLA--SGSSDKTIRLWDLETGECVRTLTGHTSYVSSVA 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958707235 207 FHPSEQLALTASGDQTAHIWryvvQLPTPQPVadtsQQISG-EDEIECSDKDEPDLDGDVSSDCPTVRV-------PLTS 278
Cdd:cd00200   101 FSPDGRILSSSSRDKTIKVW----DVETGKCL----TTLRGhTDWVNSVAFSPDGTFVASSSQDGTIKLwdlrtgkCVAT 172

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1958707235 279 LKSHQGVVIAADWLVGGKQVVTASWDRTANLYDVETSELVHSLTA 323
Cdd:cd00200   173 LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG 217
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 147-311 5.11e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.16  E-value: 5.11e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958707235 147 QLVKEYIGHRDGIWDVSVARTQPIVLGtASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:cd00200   126 KCLTTLRGHTDWVNSVAFSPDGTFVAS-SSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958707235 227 RyvvqlptpQPVADTSQQISGEDEIECSDKDEPDlDGDVSS---DCpTVRV-------PLTSLKSHQGVVIAADWLVGGK 296
Cdd:cd00200   205 D--------LSTGKCLGTLRGHENGVNSVAFSPD-GYLLASgseDG-TIRVwdlrtgeCVQTLSGHTNSVTSLAWSPDGK 274

                         170
                  ....*....|....*
gi 1958707235 297 QVVTASWDRTANLYD 311
Cdd:cd00200   275 RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
147-322 1.42e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.43  E-value: 1.42e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958707235 147 QLVKEYIGHRDGIWDVSVARTqPIVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:COG2319    69 ALLATLLGHTAAVLSVAFSPD-GRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958707235 227 RyvvqLPTPQPVADTSQQISGEDEIECSDkdepdlDGD---VSSDCPTVRV-------PLTSLKSHQGVVIAADWLVGGK 296
Cdd:COG2319   148 D----LATGKLLRTLTGHSGAVTSVAFSP------DGKllaSGSDDGTVRLwdlatgkLLRTLTGHTGAVRSVAFSPDGK 217

                         170       180
                  ....*....|....*....|....*.
gi 1958707235 297 QVVTASWDRTANLYDVETSELVHSLT 322
Cdd:COG2319   218 LLASGSADGTVRLWDLATGKLLRTLT 243
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 148-323 2.60e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.54  E-value: 2.60e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958707235 148 LVKEYIGHRDGIWDVSVARTQPIVLgTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWR 227
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLA-TGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958707235 228 yvvqLPTPQPVadtsQQISG-EDEIECSDKDEpdlDGDV----SSDCpTVRV-------PLTSLKSHQGVVIAADWLVGG 295
Cdd:cd00200    80 ----LETGECV----RTLTGhTSYVSSVAFSP---DGRIlsssSRDK-TIKVwdvetgkCLTTLRGHTDWVNSVAFSPDG 147

                         170       180
                  ....*....|....*....|....*...
gi 1958707235 296 KQVVTASWDRTANLYDVETSELVHSLTA 323
Cdd:cd00200   148 TFVASSSQDGTIKLWDLRTGKCVATLTG 175
WD40 COG2319
WD40 repeat [General function prediction only];
162-323 1.79e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.63  E-value: 1.79e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958707235 162 VSVARTQPIVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRyvvqLPTPQPVADT 241
Cdd:COG2319    41 SLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWD----LATGLLLRTL 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958707235 242 SQQISGEDEIECSDkdepdlDGD----VSSDcPTVRV-------PLTSLKSHQGVVIAADWLVGGKQVVTASWDRTANLY 310
Cdd:COG2319   117 TGHTGAVRSVAFSP------DGKtlasGSAD-GTVRLwdlatgkLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                         170
                  ....*....|...
gi 1958707235 311 DVETSELVHSLTA 323
Cdd:COG2319   190 DLATGKLLRTLTG 202
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 188-226 3.62e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 3.62e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958707235  188 TGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
189-226 1.09e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.09e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958707235 189 GKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 275-311 1.33e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 1.33e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958707235  275 PLTSLKSHQGVVIAADWLVGGKQVVTASWDRTANLYD 311
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
275-311 2.88e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 2.88e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1958707235 275 PLTSLKSHQGVVIAADWLVGGKQVVTASWDRTANLYD 311
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
DivIVA COG3599
Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle ...
 64-91 5.29e-03

Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442818 [Multi-domain]  Cd Length: 125  Bit Score: 36.37  E-value: 5.29e-03
                          10        20
                  ....*....|....*....|....*...
gi 1958707235  64 QIEREFENLYIENLELRREIDSLNERLA 91
Cdd:COG3599    31 EVAEDYERLIRENKELKEKLEELEEELE 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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