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Conserved domains on  [gi|1958699328|ref|XP_038951350|]
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prolactin family 3, subfamily A, member 1 isoform X1 [Rattus norvegicus]

Protein Classification

prolactin_like domain-containing protein( domain architecture ID 10178934)

prolactin_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
prolactin_like cd10288
Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; ...
 8-165 9.13e-74

Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; Prolactin is primarily responsible for stimulating milk production and breast development in mammals. Aside from roles in reproduction, various functions have been attributed to prolactin, more than for other pituitary gland hormones combined. These are roles in growth and development, metamorphosis, metabolism of lipids, carbohydrates, and steroids, brain biochemistry and even immunoregulation, among others. Most of these roles are poorly understood, but it has become clear that many prolactin-like hormones are actually produced in the placenta and not the pituitary.


:

Pssm-ID: 198438  Cd Length: 199  Bit Score: 219.44  E-value: 9.13e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958699328   8 GMHFAHSLGYKSRNSSTCHTISLTTPGSNEQIQQTHSDVLLKMMISILRAWYHPLEHLVHAVATLEGICETMLFKVKEVE 87
Cdd:cd10288    41 DENYAQGRGFVDRALTSCHTSSLTTPENKEQAQQIKNEDLLKLIISLLRSWNEPLKHLVTELSSMKGAPDTILSKAKEIE 120

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958699328  88 EKNQEILEKIKAILVRVYPGAEEN-VYPVWMGLADVRSANELTRHFTLSNLLHCLDSNTDKVATYLEALKCRIIHNNDC 165
Cdd:cd10288   121 EKNKELLEGLKRILSRVQPGIEENeDYPVWSGLPSLQSSDEDSRLFAFYNLFHCLRRDSHKIDTYLKLLKCRIIHGNDC 199
 
Name Accession Description Interval E-value
prolactin_like cd10288
Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; ...
 8-165 9.13e-74

Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; Prolactin is primarily responsible for stimulating milk production and breast development in mammals. Aside from roles in reproduction, various functions have been attributed to prolactin, more than for other pituitary gland hormones combined. These are roles in growth and development, metamorphosis, metabolism of lipids, carbohydrates, and steroids, brain biochemistry and even immunoregulation, among others. Most of these roles are poorly understood, but it has become clear that many prolactin-like hormones are actually produced in the placenta and not the pituitary.


Pssm-ID: 198438  Cd Length: 199  Bit Score: 219.44  E-value: 9.13e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958699328   8 GMHFAHSLGYKSRNSSTCHTISLTTPGSNEQIQQTHSDVLLKMMISILRAWYHPLEHLVHAVATLEGICETMLFKVKEVE 87
Cdd:cd10288    41 DENYAQGRGFVDRALTSCHTSSLTTPENKEQAQQIKNEDLLKLIISLLRSWNEPLKHLVTELSSMKGAPDTILSKAKEIE 120

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958699328  88 EKNQEILEKIKAILVRVYPGAEEN-VYPVWMGLADVRSANELTRHFTLSNLLHCLDSNTDKVATYLEALKCRIIHNNDC 165
Cdd:cd10288   121 EKNKELLEGLKRILSRVQPGIEENeDYPVWSGLPSLQSSDEDSRLFAFYNLFHCLRRDSHKIDTYLKLLKCRIIHGNDC 199
Hormone_1 pfam00103
Somatotropin hormone family;
9-165 2.93e-46

Somatotropin hormone family;


Pssm-ID: 306585  Cd Length: 214  Bit Score: 150.22  E-value: 2.93e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958699328   9 MHFAHSLGYKSRNSSTCHTISLTTPGSNEQIQQTHSDVLLKMMISILRAWYHPLEHLVHAVATLEGICETMLFKVKEVEE 88
Cdd:pfam00103  56 ENYAQGKGYFIRRTTSCHTNSIHTPENREKAQQTSNEELLKWSLMLLYSWLEPLYHLVTELSSMKEVSDTILSKAKDIEE 135

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958699328  89 KNQEILEKIKAILVRV-YPGAEEN-VYPVWMGLADVRSANELTRHFTLSNLLHCLDSNTDKVATYLEALKCRIIHNNDC 165
Cdd:pfam00103 136 KNKDLLEGIERIFSKViDPERTENeAYPAWSGLSSLTSSDEDRRHFAFYNLFYCLRRDSRKVDTYLKILKCRLIYKDSC 214
 
Name Accession Description Interval E-value
prolactin_like cd10288
Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; ...
 8-165 9.13e-74

Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; Prolactin is primarily responsible for stimulating milk production and breast development in mammals. Aside from roles in reproduction, various functions have been attributed to prolactin, more than for other pituitary gland hormones combined. These are roles in growth and development, metamorphosis, metabolism of lipids, carbohydrates, and steroids, brain biochemistry and even immunoregulation, among others. Most of these roles are poorly understood, but it has become clear that many prolactin-like hormones are actually produced in the placenta and not the pituitary.


Pssm-ID: 198438  Cd Length: 199  Bit Score: 219.44  E-value: 9.13e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958699328   8 GMHFAHSLGYKSRNSSTCHTISLTTPGSNEQIQQTHSDVLLKMMISILRAWYHPLEHLVHAVATLEGICETMLFKVKEVE 87
Cdd:cd10288    41 DENYAQGRGFVDRALTSCHTSSLTTPENKEQAQQIKNEDLLKLIISLLRSWNEPLKHLVTELSSMKGAPDTILSKAKEIE 120

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958699328  88 EKNQEILEKIKAILVRVYPGAEEN-VYPVWMGLADVRSANELTRHFTLSNLLHCLDSNTDKVATYLEALKCRIIHNNDC 165
Cdd:cd10288   121 EKNKELLEGLKRILSRVQPGIEENeDYPVWSGLPSLQSSDEDSRLFAFYNLFHCLRRDSHKIDTYLKLLKCRIIHGNDC 199
Hormone_1 pfam00103
Somatotropin hormone family;
9-165 2.93e-46

Somatotropin hormone family;


Pssm-ID: 306585  Cd Length: 214  Bit Score: 150.22  E-value: 2.93e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958699328   9 MHFAHSLGYKSRNSSTCHTISLTTPGSNEQIQQTHSDVLLKMMISILRAWYHPLEHLVHAVATLEGICETMLFKVKEVEE 88
Cdd:pfam00103  56 ENYAQGKGYFIRRTTSCHTNSIHTPENREKAQQTSNEELLKWSLMLLYSWLEPLYHLVTELSSMKEVSDTILSKAKDIEE 135

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958699328  89 KNQEILEKIKAILVRV-YPGAEEN-VYPVWMGLADVRSANELTRHFTLSNLLHCLDSNTDKVATYLEALKCRIIHNNDC 165
Cdd:pfam00103 136 KNKDLLEGIERIFSKViDPERTENeAYPAWSGLSSLTSSDEDRRHFAFYNLFYCLRRDSRKVDTYLKILKCRLIYKDSC 214
growth_hormone_like cd10284
Somatotropin/prolactin hormone family; The somatotropin/prolactin hormone family includes ...
 16-163 1.96e-20

Somatotropin/prolactin hormone family; The somatotropin/prolactin hormone family includes growth hormones 1 and 2, prolactin, prolactin 2, and other members that play vital roles in a variety of processes, including growth control. They are long-chain class-I helical cytokines, most of which are secreted by the pituitary gland, and are active as monomers, binding to cellular receptors with EpoR-like ligand binding domains.


Pssm-ID: 198434  Cd Length: 178  Bit Score: 82.93  E-value: 1.96e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958699328  16 GYKSRNSST--CHTISLTTPGSNEQIQQTHSDVLLKMMISILRAWYHPLEHLVHAVATLEGICETMLFKVKEVEEKNQEI 93
Cdd:cd10284    30 GENPPNNVVmsCHTASIPTPSSKEEAQQKSDKELLRISLELLQSWSEPLLHLHTVLANSKGTSLALLPKAKQVSEMLKLL 109

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958699328  94 LEKIKAILVRVYPGAEE--NVYPVWmglaDVRSANELTRHFTLSNLLHCLDSNTDKVATYLEALKCRIIHNN 163
Cdd:cd10284   110 EDGVETLSERIKDLPLEfnSVGALW----SVDETHNSLRRMHDYDLLSCFKKDAHKVETYLKILKCRRFEHS 177
prolactin_2 cd10287
Vertebrate, non-mammalian prolactin 2 (PRL2); A functionally uncharacterized subfamily of the ...
 25-165 2.62e-13

Vertebrate, non-mammalian prolactin 2 (PRL2); A functionally uncharacterized subfamily of the growth-hormone-like helical cytokines, which is found in vertebrata (except for mammals). The protein has been shown to be expressed in the zebrafish eye and brain, but not the pituitary gland, and might play a role in retina development.


Pssm-ID: 198437  Cd Length: 184  Bit Score: 64.13  E-value: 2.62e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958699328  25 CHTISLTTPGSNEQIQQTHSDVLLKMMISILRAWYHPLEHLVHAVATLEGICETMLFKVKEVEEKNQE-------ILEKI 97
Cdd:cd10287    42 CHTAGILTPNGKENAQKLEREELTEVILRLLGAWREPLSHFHQSMGHDKDFNSYSPGKAKQMSDMVHElrdgvekVTEKM 121

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958699328  98 KAILV----RVYPGAEENVYPVWMGLADVRSAneltrhftlSNLLHCLDSNTDKVATYLEALKCRIIHNNDC 165
Cdd:cd10287   122 QLLGVisnsLGGLSPEDAGPSAISGHLDAMSD---------YDLLHCFRRDSNKVQNYLKILKCRIFPESSC 184
somatolactin cd10286
Somatolactin (SL) and somatolactin-like proteins; This family of hormones specific to ...
 17-165 1.43e-06

Somatolactin (SL) and somatolactin-like proteins; This family of hormones specific to Actinopterygii is expressed in the pars intermedia bordering the neurohypophysis (posterior pituitary). Somatolactin appears to be involved in acid-base regulation, but much of its physiological role remains to be understood.


Pssm-ID: 198436  Cd Length: 207  Bit Score: 46.00  E-value: 1.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958699328  17 YKSRNSSTCHTISLTTPGSNEQIQQTHSDVLLKMMISILRAWYHPLEHLVHAVATLEGICETMLFKVKEVEEK----NQE 92
Cdd:cd10286    57 LLIQEGNACSTKTVSIPTSKTEIQQISDKWLLHSVLILVQFWIDPLVDLQTSLDRYDNAPSALLNKTKWMSTKlmnlEQG 136

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958699328  93 ILEKIKAILVRvypGAEENVYPVWMGLADVRSANELTRHFTLSNLLHCLDSNTDKVATYLEALKCRIIHNNDC 165
Cdd:cd10286   137 VLVLIRKMLGE---GMLLNNESPADTLDHFVMSDMLESVLRDYTLLSCFKKDAHKVETFLKLLKCRQTDRLNC 206
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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