NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958696183|ref|XP_038951193|]
View 

zinc finger protein 869 isoform X1 [Rattus norvegicus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0003700|GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217
PubMed:  22803940|8183940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 15-56 3.26e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 77.90  E-value: 3.26e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1958696183  15 LVSFEDLVVHFTQDEWDLLEASQKSLYGDVMLETFRNLTAVG 56
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
178-511 7.71e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 7.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958696183 178 KKLYVCQECGKAFRYPSALQLHERIHTGEKPYECKD--CGKAFRGLSALHLHERIHTGEKPYECKQCGR----------- 244
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPlsnskassssl 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958696183 245 -----AFTYLSALQLH-------------ERIHTEERPCECKQCGKTFR----------------------YSRALKLHE 284
Cdd:COG5048   111 sssssNSNDNNLLSSHslppssrdpqlpdLLSISNLRNNPLPGNNSSSVntpqsnslhpplpanslskdpsSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958696183 285 RIHTGEKPYECKQCGKFFRSHRTLKLHKRIHTGEKPYECKECGKAFRWLTSLKLHEKIHTGEKPYECQECGKAFRCQASY 364
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958696183 365 HRHKITH-------GGETLYECKECGKSFIYPSLLQVHERT--HTGE--KPFEC--KLCGKAFRCQSSLRLHERTHTGEK 431
Cdd:COG5048   271 QSSSPNEsdsssekGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958696183 432 PYECK--HCGKAFSSYN------YLRFHERSHTgEKPYEC--KECGKTFTHRSYLRSHERRHTGEKPYQC--IQCGRSFS 499
Cdd:COG5048   351 PAKEKllNSSSKFSPLLnneppqSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFN 429

                         410
                  ....*....|..
gi 1958696183 500 RHSSFKRHQSVH 511
Cdd:COG5048   430 RHYNLIPHKKIH 441
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 15-56 3.26e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 77.90  E-value: 3.26e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1958696183  15 LVSFEDLVVHFTQDEWDLLEASQKSLYGDVMLETFRNLTAVG 56
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
16-58 2.65e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 76.09  E-value: 2.65e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1958696183   16 VSFEDLVVHFTQDEWDLLEASQKSLYGDVMLETFRNLTAVGYE 58
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 16-53 3.40e-13

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 63.72  E-value: 3.40e-13
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958696183  16 VSFEDLVVHFTQDEWDLLEASQKSLYGDVMLETFRNLT 53
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
178-511 7.71e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 7.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958696183 178 KKLYVCQECGKAFRYPSALQLHERIHTGEKPYECKD--CGKAFRGLSALHLHERIHTGEKPYECKQCGR----------- 244
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPlsnskassssl 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958696183 245 -----AFTYLSALQLH-------------ERIHTEERPCECKQCGKTFR----------------------YSRALKLHE 284
Cdd:COG5048   111 sssssNSNDNNLLSSHslppssrdpqlpdLLSISNLRNNPLPGNNSSSVntpqsnslhpplpanslskdpsSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958696183 285 RIHTGEKPYECKQCGKFFRSHRTLKLHKRIHTGEKPYECKECGKAFRWLTSLKLHEKIHTGEKPYECQECGKAFRCQASY 364
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958696183 365 HRHKITH-------GGETLYECKECGKSFIYPSLLQVHERT--HTGE--KPFEC--KLCGKAFRCQSSLRLHERTHTGEK 431
Cdd:COG5048   271 QSSSPNEsdsssekGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958696183 432 PYECK--HCGKAFSSYN------YLRFHERSHTgEKPYEC--KECGKTFTHRSYLRSHERRHTGEKPYQC--IQCGRSFS 499
Cdd:COG5048   351 PAKEKllNSSSKFSPLLnneppqSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFN 429

                         410
                  ....*....|..
gi 1958696183 500 RHSSFKRHQSVH 511
Cdd:COG5048   430 RHYNLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
419-444 1.86e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.86e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958696183 419 SLRLHERTHTGEKPYECKHCGKAFSS 444
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 15-56 3.26e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 77.90  E-value: 3.26e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1958696183  15 LVSFEDLVVHFTQDEWDLLEASQKSLYGDVMLETFRNLTAVG 56
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
16-58 2.65e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 76.09  E-value: 2.65e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1958696183   16 VSFEDLVVHFTQDEWDLLEASQKSLYGDVMLETFRNLTAVGYE 58
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 16-53 3.40e-13

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 63.72  E-value: 3.40e-13
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958696183  16 VSFEDLVVHFTQDEWDLLEASQKSLYGDVMLETFRNLT 53
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
178-511 7.71e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 7.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958696183 178 KKLYVCQECGKAFRYPSALQLHERIHTGEKPYECKD--CGKAFRGLSALHLHERIHTGEKPYECKQCGR----------- 244
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPlsnskassssl 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958696183 245 -----AFTYLSALQLH-------------ERIHTEERPCECKQCGKTFR----------------------YSRALKLHE 284
Cdd:COG5048   111 sssssNSNDNNLLSSHslppssrdpqlpdLLSISNLRNNPLPGNNSSSVntpqsnslhpplpanslskdpsSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958696183 285 RIHTGEKPYECKQCGKFFRSHRTLKLHKRIHTGEKPYECKECGKAFRWLTSLKLHEKIHTGEKPYECQECGKAFRCQASY 364
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958696183 365 HRHKITH-------GGETLYECKECGKSFIYPSLLQVHERT--HTGE--KPFEC--KLCGKAFRCQSSLRLHERTHTGEK 431
Cdd:COG5048   271 QSSSPNEsdsssekGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958696183 432 PYECK--HCGKAFSSYN------YLRFHERSHTgEKPYEC--KECGKTFTHRSYLRSHERRHTGEKPYQC--IQCGRSFS 499
Cdd:COG5048   351 PAKEKllNSSSKFSPLLnneppqSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFN 429

                         410
                  ....*....|..
gi 1958696183 500 RHSSFKRHQSVH 511
Cdd:COG5048   430 RHYNLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
419-444 1.86e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.86e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958696183 419 SLRLHERTHTGEKPYECKHCGKAFSS 444
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
475-500 1.93e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.93e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958696183 475 YLRSHERRHTGEKPYQCIQCGRSFSR 500
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
447-472 2.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.07e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958696183 447 YLRFHERSHTGEKPYECKECGKTFTH 472
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-418 2.26e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 2.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958696183 171 EDKIHTGKKLYVCQECGKAFRYPSALQLHERIHTgEKPYECKDCGKAFRGLSALHLHERIHTGEKPYECKQCGRAFTYLS 250
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958696183 251 ALQLHERIHTEER-------PCECKQCGKTFRYSRALKLHER--IHTGE--KPYEC--KQCGKFFRSHRTLKLHKRIHTG 317
Cdd:COG5048   269 SSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTS 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958696183 318 EKPYECKEC-------GKAFRWLTSLKLHEKIHTGEKPYEC--QECGKAFRCQASYHRHKITHGGETLYECK--ECGKSF 386
Cdd:COG5048   349 ISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSF 428

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1958696183 387 IYPSLLQVHERTHTGEKPFECKLCGKAFRCQS 418
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
136-368 3.31e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 3.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958696183 136 NGHHNYDYKELRGSQTEEND-CEGNSCDKTSGSLQKEDKIHTGKKLYVCQECGKAFRYPSALQLHERIHTG-EKPYECKD 213
Cdd:COG5048   215 SSDQNLENSSSSLPLTTNSQlSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQ 294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958696183 214 CGKAFRGLSALHLHER--IHTGE--KPYEC--KQCGRAFTYLSALQLHERIHT--EERPCECKQCGKTFR-----YSRAL 280
Cdd:COG5048   295 CNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTsiSPAKEKLLNSSSKFSpllnnEPPQS 374

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958696183 281 KLHERIHTGEKPYEC--KQCGKFFRSHRTLKLHKRIHTGEKPYECK--ECGKAFRWLTSLKLHEKIHTGEKPYECQECGK 356
Cdd:COG5048   375 LQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454

                         250
                  ....*....|..
gi 1958696183 357 AFRCQASYHRHK 368
Cdd:COG5048   455 FRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
308-330 3.48e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.48e-04
                          10        20
                  ....*....|....*....|...
gi 1958696183 308 LKLHKRIHTGEKPYECKECGKAF 330
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
335-360 4.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.07e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958696183 335 SLKLHEKIHTGEKPYECQECGKAFRC 360
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
392-416 4.11e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.11e-04
                          10        20
                  ....*....|....*....|....*
gi 1958696183 392 LQVHERTHTGEKPFECKLCGKAFRC 416
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
279-304 5.68e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.68e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958696183 279 ALKLHERIHTGEKPYECKQCGKFFRS 304
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
195-218 6.09e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.09e-04
                          10        20
                  ....*....|....*....|....
gi 1958696183 195 ALQLHERIHTGEKPYECKDCGKAF 218
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
192-444 6.81e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 6.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958696183 192 YPSALQLHERIHTGEKPYECKDCGKAFRGLSALHLHERIHTGEKPYECKQCGRAFTYLSALQLHERIHTEERPCECKQCG 271
Cdd:COG5048   182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958696183 272 KTFRYSRALKLHERIHTGE-------KPYECKQCGK-FFRSHrTLKLHKR--IHTGE--KPYECKE--CGKAFRWLTSLK 337
Cdd:COG5048   262 RSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNIsFSRSS-PLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALK 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958696183 338 LHEKIHTGEKPYEC--QECGKAF-------RCQASYHRHKITHGGETLYECKECGKSFIYPSLLQVHERTHTGEKP--FE 406
Cdd:COG5048   341 RHILLHTSISPAKEklLNSSSKFspllnnePPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPynCK 420

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1958696183 407 CKLCGKAFRCQSSLRLHERTHTGEKPYECKHCGKAFSS 444
Cdd:COG5048   421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 401-456 1.14e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.14e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958696183 401 GEKPFECKL--CGKAFRCQSSLRLH---------------ERTHTG----EKPYECKHCGKAFSSYNYLRFHeRSHT 456
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
227-248 3.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.08e-03
                          10        20
                  ....*....|....*....|..
gi 1958696183 227 HERIHTGEKPYECKQCGRAFTY 248
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 461-483 5.36e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.36e-03
                          10        20
                  ....*....|....*....|...
gi 1958696183 461 YECKECGKTFTHRSYLRSHERRH 483
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
459-515 9.34e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.52  E-value: 9.34e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958696183 459 KPYECKECGKTFTHRSYLRSHERRHTGEKPYQCIQCGR--SFSRHSSFKRHQSVHGESP 515
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNP 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH