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Conserved domains on  [gi|1958690934|ref|XP_038950927|]
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anoctamin-8 isoform X3 [Rattus norvegicus]

Protein Classification

anoctamin family protein( domain architecture ID 10518511)

anoctamin family protein similar to anoctamin (anion channel with 8 transmembrane domains), which is a calcium-activated protein and may mediate the calcium-dependent exposure of phospholipids to the extracellular surface, a process called phospholipid scrambling

Gene Ontology:  GO:0005509|GO:0005254|GO:1902476
PubMed:  24692353|21607626|23532839|28724583|19015192
SCOP:  4004881
TCDB:  1.A.17

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
 198-500 9.33e-73

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


:

Pssm-ID: 461349  Cd Length: 377  Bit Score: 246.73  E-value: 9.33e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  198 ICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFTEAdqTSRDVSCVVFALFNVIWSTLFLEEWKRRGAELAYKWGTL 277
Cdd:pfam04547    1 IRDYFGEKIAFYFAFLGFYTKWLLPPAIVGLLVFLYGLA--TLFDPYTVFFAIFMSLWATLFLEFWKRREAELAYRWGTT 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  278 DSpgEAVEEPRPQFRGI-RRISPITRAEEFYYPPWKRLLFQLLVSLPLCLAcLVCVFVLmlgcfqlqelvlsvkglprlv 356
Cdd:pfam04547   79 GF--EEEEEPRPEFKGEkERINPVTGEKEPYYPPWKRRLRRYLLSIPLVLL-LIALLVL--------------------- 134

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  357 rflpkVILALLVSVsaegYKKLAVWLNDMENYRLESTYERHLIIKVVLfqfvnsylslfyigfylkdmdrlkelllllsl 436
Cdd:pfam04547  135 -----GVIIYLNFV----YTKLAKKLTDWENHRTQSEYENSLILKVFL-------------------------------- 173

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958690934  437 tqsleRQLRaalvplaalrfrllllslrglllvaraKMLATLLITRQLLQNVREVLQPHLYRRL 500
Cdd:pfam04547  174 -----DRLR---------------------------IQLAIIMVTKQIINNITEVVLPYLKRKR 205
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
 705-874 1.33e-68

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


:

Pssm-ID: 461349  Cd Length: 377  Bit Score: 234.78  E-value: 1.33e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  705 RQKRHNRSSWIDPPEEEHSPQLTQAELESCMKKYEDtFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFKL 784
Cdd:pfam04547  211 KKKKKEEPSVSIKDEPEESEFLERVEKEYELEPYDG-LDDYLEMVIQFGYVTLFSAAFPLAPLFALLNNIIEIRSDAFKL 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  785 CTGLQRPFGQRVESIGQWQKVMEAMGVLAIVVNCYLIGQCGQLQRLFPWlspeAAIVS-VVVLEHLALLVKYLIHAAIPD 863
Cdd:pfam04547  290 CTELRRPVPERADSIGPWLNILEFLSWLAVITNAALIYAFTSDQYWSLL----ALLLAfVIVFEHVVLLLKFLIAWLIPD 365

                          170
                   ....*....|.
gi 1958690934  864 IPGWVAEEMAK 874
Cdd:pfam04547  366 VPEWVRKERKR 376
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
922-1100 6.90e-07

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK12323:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 700  Bit Score: 53.34  E-value: 6.90e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  922 GGREEARAEAPGPDPAAERGAAKAKGSERPRRPGALLPPGPVlrlkqiiplQTRPPAPTGCAPPPRSPADTRLPAFLSLR 1001
Cdd:PRK12323   370 GGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPA---------AAAAARAVAAAPARRSPAPEALAAARQAS 440

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934 1002 FLKAPERGPSPPRPGKLFAFAAREPaangalgggarshrSAGDEPAAAELEPRPEDAGPASPPAGCWRWDAPWgcGDNPP 1081
Cdd:PRK12323   441 ARGPGGAPAPAPAPAAAPAAAARPA--------------AAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPW--EELPP 504

                          170       180
                   ....*....|....*....|
gi 1958690934 1082 RVPADAPARP-AQPACWPTA 1100
Cdd:PRK12323   505 EFASPAPAQPdAAPAGWVAE 524
 
Name Accession Description Interval E-value
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
 198-500 9.33e-73

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


Pssm-ID: 461349  Cd Length: 377  Bit Score: 246.73  E-value: 9.33e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  198 ICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFTEAdqTSRDVSCVVFALFNVIWSTLFLEEWKRRGAELAYKWGTL 277
Cdd:pfam04547    1 IRDYFGEKIAFYFAFLGFYTKWLLPPAIVGLLVFLYGLA--TLFDPYTVFFAIFMSLWATLFLEFWKRREAELAYRWGTT 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  278 DSpgEAVEEPRPQFRGI-RRISPITRAEEFYYPPWKRLLFQLLVSLPLCLAcLVCVFVLmlgcfqlqelvlsvkglprlv 356
Cdd:pfam04547   79 GF--EEEEEPRPEFKGEkERINPVTGEKEPYYPPWKRRLRRYLLSIPLVLL-LIALLVL--------------------- 134

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  357 rflpkVILALLVSVsaegYKKLAVWLNDMENYRLESTYERHLIIKVVLfqfvnsylslfyigfylkdmdrlkelllllsl 436
Cdd:pfam04547  135 -----GVIIYLNFV----YTKLAKKLTDWENHRTQSEYENSLILKVFL-------------------------------- 173

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958690934  437 tqsleRQLRaalvplaalrfrllllslrglllvaraKMLATLLITRQLLQNVREVLQPHLYRRL 500
Cdd:pfam04547  174 -----DRLR---------------------------IQLAIIMVTKQIINNITEVVLPYLKRKR 205
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
 705-874 1.33e-68

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


Pssm-ID: 461349  Cd Length: 377  Bit Score: 234.78  E-value: 1.33e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  705 RQKRHNRSSWIDPPEEEHSPQLTQAELESCMKKYEDtFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFKL 784
Cdd:pfam04547  211 KKKKKEEPSVSIKDEPEESEFLERVEKEYELEPYDG-LDDYLEMVIQFGYVTLFSAAFPLAPLFALLNNIIEIRSDAFKL 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  785 CTGLQRPFGQRVESIGQWQKVMEAMGVLAIVVNCYLIGQCGQLQRLFPWlspeAAIVS-VVVLEHLALLVKYLIHAAIPD 863
Cdd:pfam04547  290 CTELRRPVPERADSIGPWLNILEFLSWLAVITNAALIYAFTSDQYWSLL----ALLLAfVIVFEHVVLLLKFLIAWLIPD 365

                          170
                   ....*....|.
gi 1958690934  864 IPGWVAEEMAK 874
Cdd:pfam04547  366 VPEWVRKERKR 376
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
922-1100 6.90e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 53.34  E-value: 6.90e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  922 GGREEARAEAPGPDPAAERGAAKAKGSERPRRPGALLPPGPVlrlkqiiplQTRPPAPTGCAPPPRSPADTRLPAFLSLR 1001
Cdd:PRK12323   370 GGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPA---------AAAAARAVAAAPARRSPAPEALAAARQAS 440

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934 1002 FLKAPERGPSPPRPGKLFAFAAREPaangalgggarshrSAGDEPAAAELEPRPEDAGPASPPAGCWRWDAPWgcGDNPP 1081
Cdd:PRK12323   441 ARGPGGAPAPAPAPAAAPAAAARPA--------------AAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPW--EELPP 504

                          170       180
                   ....*....|....*....|
gi 1958690934 1082 RVPADAPARP-AQPACWPTA 1100
Cdd:PRK12323   505 EFASPAPAQPdAAPAGWVAE 524
 
Name Accession Description Interval E-value
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
 198-500 9.33e-73

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


Pssm-ID: 461349  Cd Length: 377  Bit Score: 246.73  E-value: 9.33e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  198 ICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFTEAdqTSRDVSCVVFALFNVIWSTLFLEEWKRRGAELAYKWGTL 277
Cdd:pfam04547    1 IRDYFGEKIAFYFAFLGFYTKWLLPPAIVGLLVFLYGLA--TLFDPYTVFFAIFMSLWATLFLEFWKRREAELAYRWGTT 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  278 DSpgEAVEEPRPQFRGI-RRISPITRAEEFYYPPWKRLLFQLLVSLPLCLAcLVCVFVLmlgcfqlqelvlsvkglprlv 356
Cdd:pfam04547   79 GF--EEEEEPRPEFKGEkERINPVTGEKEPYYPPWKRRLRRYLLSIPLVLL-LIALLVL--------------------- 134

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  357 rflpkVILALLVSVsaegYKKLAVWLNDMENYRLESTYERHLIIKVVLfqfvnsylslfyigfylkdmdrlkelllllsl 436
Cdd:pfam04547  135 -----GVIIYLNFV----YTKLAKKLTDWENHRTQSEYENSLILKVFL-------------------------------- 173

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958690934  437 tqsleRQLRaalvplaalrfrllllslrglllvaraKMLATLLITRQLLQNVREVLQPHLYRRL 500
Cdd:pfam04547  174 -----DRLR---------------------------IQLAIIMVTKQIINNITEVVLPYLKRKR 205
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
 705-874 1.33e-68

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


Pssm-ID: 461349  Cd Length: 377  Bit Score: 234.78  E-value: 1.33e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  705 RQKRHNRSSWIDPPEEEHSPQLTQAELESCMKKYEDtFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFKL 784
Cdd:pfam04547  211 KKKKKEEPSVSIKDEPEESEFLERVEKEYELEPYDG-LDDYLEMVIQFGYVTLFSAAFPLAPLFALLNNIIEIRSDAFKL 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  785 CTGLQRPFGQRVESIGQWQKVMEAMGVLAIVVNCYLIGQCGQLQRLFPWlspeAAIVS-VVVLEHLALLVKYLIHAAIPD 863
Cdd:pfam04547  290 CTELRRPVPERADSIGPWLNILEFLSWLAVITNAALIYAFTSDQYWSLL----ALLLAfVIVFEHVVLLLKFLIAWLIPD 365

                          170
                   ....*....|.
gi 1958690934  864 IPGWVAEEMAK 874
Cdd:pfam04547  366 VPEWVRKERKR 376
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
922-1100 6.90e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 53.34  E-value: 6.90e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  922 GGREEARAEAPGPDPAAERGAAKAKGSERPRRPGALLPPGPVlrlkqiiplQTRPPAPTGCAPPPRSPADTRLPAFLSLR 1001
Cdd:PRK12323   370 GGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPA---------AAAAARAVAAAPARRSPAPEALAAARQAS 440

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934 1002 FLKAPERGPSPPRPGKLFAFAAREPaangalgggarshrSAGDEPAAAELEPRPEDAGPASPPAGCWRWDAPWgcGDNPP 1081
Cdd:PRK12323   441 ARGPGGAPAPAPAPAAAPAAAARPA--------------AAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPW--EELPP 504

                          170       180
                   ....*....|....*....|
gi 1958690934 1082 RVPADAPARP-AQPACWPTA 1100
Cdd:PRK12323   505 EFASPAPAQPdAAPAGWVAE 524
PHA03378 PHA03378
EBNA-3B; Provisional
 932-1100 2.04e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 48.91  E-value: 2.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  932 PGPD--PAAERGAAKAKGSERPRRPGALLPPGP-VLRLKQIIPLQTRPP--APTgCAPPPRSPADTRLPaflslrflkaP 1006
Cdd:PHA03378   649 PTPHqpPQVEITPYKPTWTQIGHIPYQPSPTGAnTMLPIQWAPGTMQPPprAPT-PMRPPAAPPGRAQR----------P 717

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934 1007 ERGPSPPRPGKLFAFAAREPAANGALGGGARSHRSAGDEPAAAELEPRPEDAGPASPPAgcwrwDAPWGCGDNPPRVPAD 1086
Cdd:PHA03378   718 AAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTP-----QPPPQAPPAPQQRPRG 792

                          170
                   ....*....|....
gi 1958690934 1087 APARPAQPACWPTA 1100
Cdd:PHA03378   793 APTPQPPPQAGPTS 806
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
911-1099 3.79e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 47.95  E-value: 3.79e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  911 AEQQARRERDTGGREEARAEAPGPDPAAERGAAKakgserPRRPGALLPPGPVLRLKqiiplqTRPPAPTGCAPPPRSPA 990
Cdd:PRK12323   435 AARQASARGPGGAPAPAPAPAAAPAAAARPAAAG------PRPVAAAAAAAPARAAP------AAAPAPADDDPPPWEEL 502

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  991 DTRLPAflslrflkapergPSPPRPGKLFAFAAREPAANGALGGGARSHRSAGDEPAAAELEPRPEDAGPASPPagcwrw 1070
Cdd:PRK12323   503 PPEFAS-------------PAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAP------ 563

                          170       180
                   ....*....|....*....|....*....
gi 1958690934 1071 dapwgcgdNPPRVPADAPArPAQPACWPT 1099
Cdd:PRK12323   564 --------RPPRASASGLP-DMFDGDWPA 583
PHA03247 PHA03247
large tegument protein UL36; Provisional
 927-1100 4.72e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 4.72e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  927 ARAEAPGPDPAAERGAAKAKGSERPRRPGALLPPGPVLRLKQIIPLQTRPPAPTGCAPPPRSPADTR-------LPAFLS 999
Cdd:PHA03247  2772 PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTApppppgpPPPSLP 2851

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934 1000 LRFLKAP-----ERGPSPPRPGKLfAFAAREPAANGALGGGARSHRSAGDEPAAAELEPRPEDAGPASPPAgcwrwDAPW 1074
Cdd:PHA03247  2852 LGGSVAPggdvrRRPPSRSPAAKP-AAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQP-----QPPP 2925

                          170       180
                   ....*....|....*....|....*.
gi 1958690934 1075 GCGDNPPRVPADAPARPAQPACWPTA 1100
Cdd:PHA03247  2926 PPQPQPPPPPPPRPQPPLAPTTDPAG 2951
PHA03247 PHA03247
large tegument protein UL36; Provisional
 914-1099 4.80e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 4.80e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  914 QARRERDTGGREEARAEAPGPDPAAERGAAKAkgSERPRRPGALLPPGPVLRlkqiiPLQTRPPAP-TGCAPPPRSPADT 992
Cdd:PHA03247  2583 TSRARRPDAPPQSARPRAPVDDRGDPRGPAPP--SPLPPDTHAPDPPPPSPS-----PAANEPDPHpPPTVPPPERPRDD 2655

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  993 RLPAFLSLrflkaPERGPSPPRPGKLFAfAAREPAANGALGGGARSHRSAGDEPAAAELEPRPE---DAGPASPPAGCWR 1069
Cdd:PHA03247  2656 PAPGRVSR-----PRRARRLGRAAQASS-PPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHalvSATPLPPGPAAAR 2729

                          170       180       190
                   ....*....|....*....|....*....|
gi 1958690934 1070 WDAPWGCGDNPPRVPADAPARPAQPACWPT 1099
Cdd:PHA03247  2730 QASPALPAAPAPPAVPAGPATPGGPARPAR 2759
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
935-1095 1.08e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 46.38  E-value: 1.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  935 DPAAERGAAKAkGSERPRRPGALLPPGPV---LRLKQIIPLQTRPPAPTGCAPPPRS--PADTRLPAflslrflkAPERG 1009
Cdd:PRK07003   359 EPAVTGGGAPG-GGVPARVAGAVPAPGARaaaAVGASAVPAVTAVTGAAGAALAPKAaaAAAATRAE--------APPAA 429

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934 1010 PSPPRPGKLFAFAAREPAANGALGGGARSHRSAGDEPAAAELEPRPEDAGPAS--PPAGCW----RWDAPWGCGDNPPRV 1083
Cdd:PRK07003   430 PAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASdaPPDAAFepapRAAAPSAATPAAVPD 509

                          170       180
                   ....*....|....*....|
gi 1958690934 1084 PA--------DAPARPAQPA 1095
Cdd:PRK07003   510 ARapaaasreDAPAAAAPPA 529
PHA03247 PHA03247
large tegument protein UL36; Provisional
 931-1095 1.11e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 1.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  931 APGPDPAA----ERGAAKAKGSERPRRPgallPPGPVLRLKQIIPLQTRPPAPTGCAPPPRSPADTrlPAFLSLRFLKAP 1006
Cdd:PHA03247  2628 PPSPSPAAnepdPHPPPTVPPPERPRDD----PAPGRVSRPRRARRLGRAAQASSPPQRPRRRAAR--PTVGSLTSLADP 2701

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934 1007 ERGPSPPRPgklfafaAREPAANGALGGGARSHRSAGDEPAAAELEPRPEDAGPASP--PAGCWRWDAPWG-CGDNPPRV 1083
Cdd:PHA03247  2702 PPPPPTPEP-------APHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPggPARPARPPTTAGpPAPAPPAA 2774

                          170
                   ....*....|..
gi 1958690934 1084 PADAPARPAQPA 1095
Cdd:PHA03247  2775 PAAGPPRRLTRP 2786
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
921-1095 1.22e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 46.38  E-value: 1.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  921 TGGREEARAEAPGPDPAAeRGAAKAKGSERPRRPGALLPPGPVLRlkqiiPLQTRPPAPTGCAPPPRSPAD-------TR 993
Cdd:PRK07003   368 PGGGVPARVAGAVPAPGA-RAAAAVGASAVPAVTAVTGAAGAALA-----PKAAAAAAATRAEAPPAAPAPpatadrgDD 441

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  994 LPAFLSLRFLKAPERGPSPPRPGKLFAFAAREPAANGAlgggarshrSAGDEPAAAELEPRPEDAGP----------ASP 1063
Cdd:PRK07003   442 AADGDAPVPAKANARASADSRCDERDAQPPADSGSASA---------PASDAPPDAAFEPAPRAAAPsaatpaavpdARA 512

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1958690934 1064 PAGCWRWDAPWGCGDNPPRVPADAPARPAQPA 1095
Cdd:PRK07003   513 PAAASREDAPAAAAPPAPEARPPTPAAAAPAA 544
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 911-1095 1.71e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.75  E-value: 1.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  911 AEQQARRERDTGGREEARAEAPGPDPAAERGAAKAKGSERPRRPGALLPPGpvlrlkqiiplqTRPPAPTGCAPPPRSPA 990
Cdd:PRK07764   622 AAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAK------------AGGAAPAAPPPAPAPAA 689

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  991 DTRLPAflslrflkAPERGPSPPRPgklfafAAREPAANGALGGGARSHRSAGDEPAAAELEPRPEDAGPASPPAGCWrw 1070
Cdd:PRK07764   690 PAAPAG--------AAPAQPAPAPA------ATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAG-- 753

                          170       180
                   ....*....|....*....|....*
gi 1958690934 1071 dAPWGCGDNPPRVPADAPARPAQPA 1095
Cdd:PRK07764   754 -APAQPPPPPAPAPAAAPAAAPPPS 777
PHA03247 PHA03247
large tegument protein UL36; Provisional
 926-1102 1.87e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 1.87e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  926 EARAEAPGP-DPAAERGAAKAKGSERP--RRPGALLPPGPVlrlkqiiPLQTRPPAPTGCAPP---------PRSPADTR 993
Cdd:PHA03247  2793 ESRESLPSPwDPADPPAAVLAPAAALPpaASPAGPLPPPTS-------AQPTAPPPPPGPPPPslplggsvaPGGDVRRR 2865

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  994 LPAFLSLRFLKAPER-------GPSPPRPGKLFAFAAREPAANGALGGGARSHRSAGDEPAAAE---LEPRPEDAGPASP 1063
Cdd:PHA03247  2866 PPSRSPAAKPAAPARppvrrlaRPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPqppPPPPPRPQPPLAP 2945

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1958690934 1064 PAGCWRWDAPWGCGDNP--------------PRVPADAPARPAQPACWPTARH 1102
Cdd:PHA03247  2946 TTDPAGAGEPSGAVPQPwlgalvpgrvavprFRVPQPAPSREAPASSTPPLTG 2998
PHA03247 PHA03247
large tegument protein UL36; Provisional
 910-1100 2.15e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 2.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  910 HAEQQARRERDTGGREEARAEAPGPDPAAERGAAKAKGSERPRRPGALLPPGPVLRLKQIIPlqtrPPAPTGCAPPPRSP 989
Cdd:PHA03247  2642 PPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPP----PPPTPEPAPHALVS 2717

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  990 ADTRLPAFLSLR-FLKAPERGPSPPRPGKLFAFAAREPAANGALGGGARSHRSAGDEPAAAelePRPEDAGPASPPAGCW 1068
Cdd:PHA03247  2718 ATPLPPGPAAARqASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAG---PPRRLTRPAVASLSES 2794

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1958690934 1069 RWDAP--WGCGDNPPRVPADAPA-----RPAQPACWPTA 1100
Cdd:PHA03247  2795 RESLPspWDPADPPAAVLAPAAAlppaaSPAGPLPPPTS 2833
PHA03378 PHA03378
EBNA-3B; Provisional
 970-1102 4.22e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 44.67  E-value: 4.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  970 IPLQTRPPAPTGCAPPPRSPADTRLPAflslrflkapeRGPSPPRPGKLFAFAAREPAANGALGGGARSHRSAGDEPAAA 1049
Cdd:PHA03378   672 IPYQPSPTGANTMLPIQWAPGTMQPPP-----------RAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAA 740

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958690934 1050 ELEPRPEDAGP--ASPPAGcwrwdAPWGCgdNPPRVPADAPARPAQPACWPTARH 1102
Cdd:PHA03378   741 PGRARPPAAAPgrARPPAA-----APGRA--RPPAAAPGAPTPQPPPQAPPAPQQ 788
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 910-1097 4.80e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.39  E-value: 4.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  910 HAEQQARRERDTGGREEARAEAPGPDPAAERGAAKAKGSERPRRPGALLPP-------GPVLRLKQIIPLQTRPPAPTGC 982
Cdd:PHA03307    77 TEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPpspapdlSEMLRPVGSPGPPPAASPPAAG 156

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  983 APPPRSPADTRLPAFLSLrFLKAPER------GPSPPRPGKLFAFAAREPAANGALGGGARSHRSAGDEPAAAELEPRPE 1056
Cdd:PHA03307   157 ASPAAVASDAASSRQAAL-PLSSPEEtarapsSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGAS 235

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1958690934 1057 DAGPASPPAGCWRWDAPWGCGDNPPRvPADAPARPAQPACW 1097
Cdd:PHA03307   236 SSDSSSSESSGCGWGPENECPLPRPA-PITLPTRIWEASGW 275
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
914-1101 6.29e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 44.07  E-value: 6.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  914 QARRERDTGGREEARAEAPGPDPAAERGAAKAKGSERPRRPGALLPPGPvlrlkqiiplQTRPPAPTGCAPPPRSPADTR 993
Cdd:PRK07003   434 ATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPAS----------DAPPDAAFEPAPRAAAPSAAT 503

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  994 LPAFLSLRFLKAPERGPSPPRPgklfafAAREPAANGALGGGARSHRSAGDEPAAAEL---------EPRPEDAGPASPP 1064
Cdd:PRK07003   504 PAAVPDARAPAAASREDAPAAA------APPAPEARPPTPAAAAPAARAGGAAAALDVlrnagmrvsSDRGARAAAAAKP 577

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1958690934 1065 AGcwrwdapwgcgdNPPRVPADAPARPAQPACWPTAR 1101
Cdd:PRK07003   578 AA------------APAAAPKPAAPRVAVQVPTPRAR 602
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
920-1100 7.22e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.71  E-value: 7.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  920 DTGGREEARAEAPGPDPAAERGAAKAKGSERPRRPGALLPPGPVLRLKQIIPLQTRPPAPTGCAPPPRSPADTRLPAfls 999
Cdd:PRK12323   371 GAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGA--- 447

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934 1000 lrflKAPERGPSP-PRPGKLFAFAAREPAANGALGGGARSHRSAGDEPAAA------ELEPRPEDAGPASPPAGCWRWDA 1072
Cdd:PRK12323   448 ----PAPAPAPAAaPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDdpppweELPPEFASPAPAQPDAAPAGWVA 523

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1958690934 1073 PW----GCGDNPPRVPADAPARPAQPACWPTA 1100
Cdd:PRK12323   524 ESipdpATADPDDAFETLAPAPAAAPAPRAAA 555
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 941-1101 1.52e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 1.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  941 GAAKAKGSERPRRPGALLPPGPvlrlkqiiplQTRPPAPTGCAPPPRSPADtrlpaflslrflkAPERGPSPPRPGKLFA 1020
Cdd:PRK07764   590 PAPGAAGGEGPPAPASSGPPEE----------AARPAAPAAPAAPAAPAPA-------------GAAAAPAEASAAPAPG 646

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934 1021 FAAREPAANGALGGGArshrSAGDEPAAAELEPRPEDAGPASPPAGCWRWDAPWGCGDNPPRVPADAPARPAQPAcWPTA 1100
Cdd:PRK07764   647 VAAPEHHPKHVAVPDA----SDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDP-AAQP 721


                   .
gi 1958690934 1101 R 1101
Cdd:PRK07764   722 P 722
PHA03247 PHA03247
large tegument protein UL36; Provisional
 934-1094 1.86e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 1.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  934 PDPAAERGAAKAKGSE---RPRRPGALLPPGPVLRLKQiiPLQTRPPAPTgcapPPRSPADTRLPAFLSLRFLKAPERGP 1010
Cdd:PHA03247  2723 PGPAAARQASPALPAApapPAVPAGPATPGGPARPARP--PTTAGPPAPA----PPAAPAAGPPRRLTRPAVASLSESRE 2796

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934 1011 SPPRPGKLFAFAAREPAANGALGGGARSHRSAGDEPAAAELEPrPEDAGPASPPAGCWRWDAPWG--CGDNPPRVPADAP 1088
Cdd:PHA03247  2797 SLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAP-PPPPGPPPPSLPLGGSVAPGGdvRRRPPSRSPAAKP 2875


                   ....*.
gi 1958690934 1089 ARPAQP 1094
Cdd:PHA03247  2876 AAPARP 2881
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 927-1095 7.51e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 7.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934  927 ARAEAPgpdpaaERGAAKAKGSERPRRPGALLPPGPvlrlkqiiplqtRPPAPTGCAPPPRSPADTRLPAFlslrflKAP 1006
Cdd:PRK07764   376 ARLERL------ERRLGVAGGAGAPAAAAPSAAAAA------------PAAAPAPAAAAPAAAAAPAPAAA------PQP 431

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690934 1007 ERGPSPPrpgklfafAAREPAANGALGGGARSHRSAGDEPAaaelEPRPEDAGPASPPAGCWRWDAPWGCGDNPPRVPAD 1086
Cdd:PRK07764   432 APAPAPA--------PAPPSPAGNAPAGGAPSPPPAAAPSA----QPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAA 499


                   ....*....
gi 1958690934 1087 APARPAQPA 1095
Cdd:PRK07764   500 PAAPAGADD 508
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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