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Conserved domains on  [gi|1958683727|ref|XP_038950428|]
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F-box only protein 8 isoform X3 [Rattus norvegicus]

Protein Classification

COG5307 family protein( domain architecture ID 10074493)

COG5307 family protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
1-155 1.12e-56

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


:

Pssm-ID: 238100  Cd Length: 185  Bit Score: 175.49  E-value: 1.12e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958683727   1 MSKGIL-DDSPKEIAKFIFCTRTLNWKKLRIYLDER----RDVLDDLVTLHNFRNQFLPNALREFFRHIHAPEERgEYLE 75
Cdd:cd00171    24 IEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENnefnSLVLHEFVDLFDFSGLRLDEALRKFLQSFRLPGEA-QKID 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958683727  76 TLITKFSHRFCACNPDLMrelGLSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTRRAAQ--NISEDFVGHLYDN 153
Cdd:cd00171   103 RLLEKFSERYCECNPGIF---SSSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNLRGINDgeDFPREFLKELYDS 179

                  ..
gi 1958683727 154 IY 155
Cdd:cd00171   180 IK 181
 
Name Accession Description Interval E-value
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
1-155 1.12e-56

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 175.49  E-value: 1.12e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958683727   1 MSKGIL-DDSPKEIAKFIFCTRTLNWKKLRIYLDER----RDVLDDLVTLHNFRNQFLPNALREFFRHIHAPEERgEYLE 75
Cdd:cd00171    24 IEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENnefnSLVLHEFVDLFDFSGLRLDEALRKFLQSFRLPGEA-QKID 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958683727  76 TLITKFSHRFCACNPDLMrelGLSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTRRAAQ--NISEDFVGHLYDN 153
Cdd:cd00171   103 RLLEKFSERYCECNPGIF---SSSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNLRGINDgeDFPREFLKELYDS 179

                  ..
gi 1958683727 154 IY 155
Cdd:cd00171   180 IK 181
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
1-155 6.30e-53

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 166.31  E-value: 6.30e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958683727    1 MSKGIL-DDSPKEIAKFIFCTRTLNWKKLRIYLDER----RDVLDDLVTLHNFRNQFLPNALREFFRHIHAPEErGEYLE 75
Cdd:smart00222  27 QEKGFLaNEDPQDVADFLSKNEGLNKKAIGDYLGEHdefnRLVLHAFVDLFDFSAKDLDQALREFLESFRLPGE-AQKID 105
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958683727   76 TLITKFSHRFCACNPDLMRELglSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTRRAA--QNISEDFVGHLYDN 153
Cdd:smart00222 106 RLLEAFSSRYCECNPGVFSKA--NADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFIKNVRGSNdgEDLPREFLEELYDS 183

                   ..
gi 1958683727  154 IY 155
Cdd:smart00222 184 IK 185
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
1-154 4.14e-44

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 143.37  E-value: 4.14e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958683727   1 MSKGILDDSPKEIAKFIFCTRTLNWKKLRIYLDER----RDVLDDLVTLHNFRNQFLPNALREFFRHIHAPEErGEYLET 76
Cdd:pfam01369  24 IEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPdefnIEVLKAFVDLFDFKGLRIDEALRLFLESFRLPGE-AQKIDR 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958683727  77 LITKFSHRFCACNPDLMRelglSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTRR--AAQNISEDFVGHLYDNI 154
Cdd:pfam01369 103 IMEAFAERYYEQNPGVFA----NADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLRGinDGKDFPDEYLEEIYDSI 178
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
8-154 6.41e-26

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 102.59  E-value: 6.41e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958683727    8 DSPKEIAKFIFCTRTLNWKKLRIYLDERRD----VLDDLVTLHNFRNQFLPNALREFFRHIHAPEErGEYLETLITKFSH 83
Cdd:PLN03076   646 ESPEEIAAFLKDASGLNKTLIGDYLGEREDlslkVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGE-AQKIDRIMEKFAE 724
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958683727   84 RFCACNPDLMRelglSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTR--RAAQNISEDFVGHLYDNI 154
Cdd:PLN03076   725 RYCKCNPKAFS----SADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRgiDDGKDLPEEFMRSLYERI 793
 
Name Accession Description Interval E-value
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
1-155 1.12e-56

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 175.49  E-value: 1.12e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958683727   1 MSKGIL-DDSPKEIAKFIFCTRTLNWKKLRIYLDER----RDVLDDLVTLHNFRNQFLPNALREFFRHIHAPEERgEYLE 75
Cdd:cd00171    24 IEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENnefnSLVLHEFVDLFDFSGLRLDEALRKFLQSFRLPGEA-QKID 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958683727  76 TLITKFSHRFCACNPDLMrelGLSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTRRAAQ--NISEDFVGHLYDN 153
Cdd:cd00171   103 RLLEKFSERYCECNPGIF---SSSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNLRGINDgeDFPREFLKELYDS 179

                  ..
gi 1958683727 154 IY 155
Cdd:cd00171   180 IK 181
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
1-155 6.30e-53

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 166.31  E-value: 6.30e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958683727    1 MSKGIL-DDSPKEIAKFIFCTRTLNWKKLRIYLDER----RDVLDDLVTLHNFRNQFLPNALREFFRHIHAPEErGEYLE 75
Cdd:smart00222  27 QEKGFLaNEDPQDVADFLSKNEGLNKKAIGDYLGEHdefnRLVLHAFVDLFDFSAKDLDQALREFLESFRLPGE-AQKID 105
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958683727   76 TLITKFSHRFCACNPDLMRELglSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTRRAA--QNISEDFVGHLYDN 153
Cdd:smart00222 106 RLLEAFSSRYCECNPGVFSKA--NADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFIKNVRGSNdgEDLPREFLEELYDS 183

                   ..
gi 1958683727  154 IY 155
Cdd:smart00222 184 IK 185
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
1-154 4.14e-44

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 143.37  E-value: 4.14e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958683727   1 MSKGILDDSPKEIAKFIFCTRTLNWKKLRIYLDER----RDVLDDLVTLHNFRNQFLPNALREFFRHIHAPEErGEYLET 76
Cdd:pfam01369  24 IEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPdefnIEVLKAFVDLFDFKGLRIDEALRLFLESFRLPGE-AQKIDR 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958683727  77 LITKFSHRFCACNPDLMRelglSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTRR--AAQNISEDFVGHLYDNI 154
Cdd:pfam01369 103 IMEAFAERYYEQNPGVFA----NADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLRGinDGKDFPDEYLEEIYDSI 178
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
8-154 6.41e-26

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 102.59  E-value: 6.41e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958683727    8 DSPKEIAKFIFCTRTLNWKKLRIYLDERRD----VLDDLVTLHNFRNQFLPNALREFFRHIHAPEErGEYLETLITKFSH 83
Cdd:PLN03076   646 ESPEEIAAFLKDASGLNKTLIGDYLGEREDlslkVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGE-AQKIDRIMEKFAE 724
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958683727   84 RFCACNPDLMRelglSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTR--RAAQNISEDFVGHLYDNI 154
Cdd:PLN03076   725 RYCKCNPKAFS----SADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRgiDDGKDLPEEFMRSLYERI 793
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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