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Conserved domains on  [gi|1958681673|ref|XP_038949812|]
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histone-lysine N-methyltransferase SETDB2 isoform X7 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET super family cl40432
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 210-420 1.49e-82

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


The actual alignment was detected with superfamily member cd10523:

Pssm-ID: 394802 [Multi-domain]  Cd Length: 266  Bit Score: 257.45  E-value: 1.49e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958681673 210 FSFNTYVQLTRNHPKQNEVVSDVDISNGVesvsisfcnevdnsklpqfkyrttvwprayhlnvssmFSDSCDCSEGCIDI 289
Cdd:cd10523     1 FSFNTYVQLDRNPQDQQQLVDDFDISNGA-------------------------------------FVDSCDCTDGCIDI 43

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958681673 290 KKCACLQLTAKNAKACPLSPDGECTGYKYKRLQRLIPSGIYECNLFCKCNRQMCQNRVIQHGPRVRLQVFKSEKKGWGVR 369
Cdd:cd10523    44 LKCACLQLTARAFSKSESSPSKGGRGYKYKRLQEPIPSGLYECNVSCKCNRMLCQNRVVQHGLQVRLQVFKTEKKGWGVR 123

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958681673 370 CLDDIDKGTFVCIYSGRLLSRAT------PEKTNIGESESEQQHTVKNSFSKKRKIE 420
Cdd:cd10523   124 CLDDIDKGTFVCIYAGRVLSRARspteplPPKLELPSENEVEVVTSWLILSKKRKLR 180
HMT_MBD cd01395
Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as ...
 152-212 1.27e-24

Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated transcriptional repression. SETDB1 and other proteins in this group have a similar domain architecture. SETDB1 is a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.


:

Pssm-ID: 238689  Cd Length: 60  Bit Score: 96.68  E-value: 1.27e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958681673 152 PLQLPLRCHFQRRHAKTNSPSAALHVNYRTPCGRSLRNMEEVFHYLLETeCNFLFTDNFSF 212
Cdd:cd01395     1 PLHTPLLCGFQRMKYRARVGKVKKHVIYKAPCGRSLRNMSEVHRYLRET-CSFLTVDNFSF 60
 
Name Accession Description Interval E-value
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 210-420 1.49e-82

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 257.45  E-value: 1.49e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958681673 210 FSFNTYVQLTRNHPKQNEVVSDVDISNGVesvsisfcnevdnsklpqfkyrttvwprayhlnvssmFSDSCDCSEGCIDI 289
Cdd:cd10523     1 FSFNTYVQLDRNPQDQQQLVDDFDISNGA-------------------------------------FVDSCDCTDGCIDI 43

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958681673 290 KKCACLQLTAKNAKACPLSPDGECTGYKYKRLQRLIPSGIYECNLFCKCNRQMCQNRVIQHGPRVRLQVFKSEKKGWGVR 369
Cdd:cd10523    44 LKCACLQLTARAFSKSESSPSKGGRGYKYKRLQEPIPSGLYECNVSCKCNRMLCQNRVVQHGLQVRLQVFKTEKKGWGVR 123

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958681673 370 CLDDIDKGTFVCIYSGRLLSRAT------PEKTNIGESESEQQHTVKNSFSKKRKIE 420
Cdd:cd10523   124 CLDDIDKGTFVCIYAGRVLSRARspteplPPKLELPSENEVEVVTSWLILSKKRKLR 180
HMT_MBD cd01395
Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as ...
 152-212 1.27e-24

Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated transcriptional repression. SETDB1 and other proteins in this group have a similar domain architecture. SETDB1 is a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.


Pssm-ID: 238689  Cd Length: 60  Bit Score: 96.68  E-value: 1.27e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958681673 152 PLQLPLRCHFQRRHAKTNSPSAALHVNYRTPCGRSLRNMEEVFHYLLETeCNFLFTDNFSF 212
Cdd:cd01395     1 PLHTPLLCGFQRMKYRARVGKVKKHVIYKAPCGRSLRNMSEVHRYLRET-CSFLTVDNFSF 60
Pre-SET pfam05033
Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines ...
 234-346 1.78e-18

Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilising SET domains.


Pssm-ID: 461530 [Multi-domain]  Cd Length: 99  Bit Score: 80.54  E-value: 1.78e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958681673 234 ISNGVESVSISFCNEVDNSKLP-QFKYRTTVWpraYHLNVSSMFSDSCDCsEGCIDiKKCACLQLTaknakacplsPDGE 312
Cdd:pfam05033   1 ISKGKENVPIPVVNEVDDEPPPpDFTYITSYI---YPKEFLLIIPQGCDC-GDCSS-EKCSCAQLN----------GGEF 65

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1958681673 313 CTGYKYKRLQRL-IPSGIYECNLFCKCnRQMCQNR 346
Cdd:pfam05033  66 RFPYDKDGLLVPeSKPPIYECNPLCGC-PPSCPNR 99
PreSET smart00468
N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal ...
 233-337 6.08e-12

N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal to some SET domains. Function is unknown. Unpublished.


Pssm-ID: 128744 [Multi-domain]  Cd Length: 98  Bit Score: 62.05  E-value: 6.08e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958681673  233 DISNGVESVSISFCNEVDNSKLP-QFKY-RTTVWPRAYHLNVSSMFSDSCDCSEGCIDIKKCACLQLTaknakacplspD 310
Cdd:smart00468   3 DISNGKENVPVPLVNEVDEDPPPpDFEYiSEYIYGQGVPIDRSPSPLVGCSCSGDCSSSNKCECARKN-----------G 71

                           90       100
                   ....*....|....*....|....*..
gi 1958681673  311 GECTGYKYKRLQRLIPSGIYECNLFCK 337
Cdd:smart00468  72 GEFAYELNGGLRLKRKPLIYECNSRCS 98
MBD smart00391
Methyl-CpG binding domain; Methyl-CpG binding domain, also known as the TAM (TTF-IIP5, ARBP, ...
 150-216 4.85e-10

Methyl-CpG binding domain; Methyl-CpG binding domain, also known as the TAM (TTF-IIP5, ARBP, MeCP1) domain


Pssm-ID: 128673  Cd Length: 77  Bit Score: 55.84  E-value: 4.85e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958681673  150 ENPLQLPLRCHFQRRHA--KTNSPSAALHVNYRTPCGRSLRNMEEVFHYLLETECNFLFTDNFSFNTYV 216
Cdd:smart00391   1 GDPLRLPLPCGWRRETKqrKSGRSAGKFDVYYISPCGKKLRSKSELARYLHKNGDLSLDLECFDFNATV 69
MBD pfam01429
Methyl-CpG binding domain; The Methyl-CpG binding domain (MBD) binds to DNA that contains one ...
 149-216 1.70e-07

Methyl-CpG binding domain; The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase.


Pssm-ID: 396147 [Multi-domain]  Cd Length: 76  Bit Score: 48.51  E-value: 1.70e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958681673 149 GENPLQLPLRCHFQR--RHAKTNSPSAALHVNYRTPCGRSLRNMEEVFHYLLETECNFLFTDNFSFNTYV 216
Cdd:pfam01429   3 RKREDRLPLPPGWRReeRQRKSGSKAGKVDVFYYSPTGKKLRSKSEVARYLEANGGTSPKLEDFSFTVRS 72
 
Name Accession Description Interval E-value
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 210-420 1.49e-82

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 257.45  E-value: 1.49e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958681673 210 FSFNTYVQLTRNHPKQNEVVSDVDISNGVesvsisfcnevdnsklpqfkyrttvwprayhlnvssmFSDSCDCSEGCIDI 289
Cdd:cd10523     1 FSFNTYVQLDRNPQDQQQLVDDFDISNGA-------------------------------------FVDSCDCTDGCIDI 43

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958681673 290 KKCACLQLTAKNAKACPLSPDGECTGYKYKRLQRLIPSGIYECNLFCKCNRQMCQNRVIQHGPRVRLQVFKSEKKGWGVR 369
Cdd:cd10523    44 LKCACLQLTARAFSKSESSPSKGGRGYKYKRLQEPIPSGLYECNVSCKCNRMLCQNRVVQHGLQVRLQVFKTEKKGWGVR 123

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958681673 370 CLDDIDKGTFVCIYSGRLLSRAT------PEKTNIGESESEQQHTVKNSFSKKRKIE 420
Cdd:cd10523   124 CLDDIDKGTFVCIYAGRVLSRARspteplPPKLELPSENEVEVVTSWLILSKKRKLR 180
SET_SETDB cd10541
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), ...
 265-423 3.08e-65

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), SET domain bifurcated 2 (SETDB2), and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380939 [Multi-domain]  Cd Length: 236  Bit Score: 211.63  E-value: 3.08e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958681673 265 PRAYHLNVS-SMFSDSCDCSEGCIDIKKCACLQLTAKNAKACPLSPDGECTGYKYKRLQRLIPSGIYECNLFCKCNRQMC 343
Cdd:cd10541     2 PFYYIPDISyGKFLVGCDCTDGCRDKSKCACHQLTIQATACTPGGQDNPTAGYQYKRLEECLPTGVYECNKLCKCDPNMC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958681673 344 QNRVIQHGPRVRLQVFKSEKKGWGVRCLDDIDKGTFVCIYSGRLLSRATPEKtnigesesEQQHTVKNSFSKKRKIEVVC 423
Cdd:cd10541    82 QNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGTFVCIYAGKILTDDFADK--------EGLEMGDEYFANLDHIEESC 153
SET_SETDB1 cd10517
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 233-389 1.70e-58

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.


Pssm-ID: 380915 [Multi-domain]  Cd Length: 288  Bit Score: 195.59  E-value: 1.70e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958681673 233 DISNGVESVSISFCNEVDNSKLPQFKYRTTVWPRA-YHLNVSSMFSDSCDCSEGCIDIKKCACLQLTAKNAKACPLSPDG 311
Cdd:cd10517     8 DISYGKEGVPIPCVNEIDNSSPPYVEYSKERIPGKgVNINLDPDFLVGCDCTDGCRDKSKCACQQLTIEATAATPGGQIN 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958681673 312 ECTGYKYKRLQRLIPSGIYECNLFCKCNRqMCQNRVIQHGPRVRLQVFKSEKKGWGVRCLDDIDKGTFVCIYSGRLLS 389
Cdd:cd10517    88 PSAGYQYRRLMEKLPTGVYECNSRCKCDK-RCYNRVVQNGLQVRLQVFKTEKKGWGIRCLDDIPKGSFVCIYAGQILT 164
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 256-389 2.54e-33

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 125.95  E-value: 2.54e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958681673 256 QFKYRTTVWPRAYHLNVSSmFSDSCDCSEGCIDiKKCACLQLTAKNakacplspdgecTGYKYKRLQRLIPSG--IYECN 333
Cdd:cd10538     4 TYIKDNIVGKNVQPFSNII-DSVGCKCKDDCLD-SKCACAAESDGI------------FAYTKNGLLRLNNSPppIFECN 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958681673 334 LFCKCNRqMCQNRVIQHGPRVRLQVFKSEKKGWGVRCLDDIDKGTFVCIYSGRLLS 389
Cdd:cd10538    70 SKCSCDD-DCKNRVVQRGLQARLQVFRTSKKGWGVRSLEFIPKGSFVCEYVGEVIT 124
SET_AtSUVH-like cd10545
SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...
 277-396 9.34e-28

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380943 [Multi-domain]  Cd Length: 232  Bit Score: 110.96  E-value: 9.34e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958681673 277 SDSCDCSEGCIDI-KKCAClqlTAKNAKACPLSPDGectgykykRLQRLIPSgIYECNLFCKCNRQmCQNRVIQHGPRVR 355
Cdd:cd10545    21 STGCDCKNRCTDGaSDCAC---VKKNGGEIPYNFNG--------RLIRAKPA-IYECGPLCKCPPS-CYNRVTQKGLRYR 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1958681673 356 LQVFKSEKKGWGVRCLDDIDKGTFVCIYSGRLLSRATPEKT 396
Cdd:cd10545    88 LEVFKTAERGWGVRSWDSIPAGSFICEYVGELLDTSEADTR 128
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 271-389 1.12e-24

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 102.42  E-value: 1.12e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958681673 271 NVSSMfsDSCDCSEGCiDIKKCACLQLTAKNA--KACPLSPDgectgykykrLQRLIPSGIYECNLFCKCNRQmCQNRVI 348
Cdd:cd10543    20 NITSL--QTCSCRDDC-SSDNCVCGRLSVRCWydKEGRLLPD----------FNKLDPPLIFECNRACSCWRN-CRNRVV 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1958681673 349 QHGPRVRLQVFKSEKKGWGVRCLDDIDKGTFVCIYSGRLLS 389
Cdd:cd10543    86 QNGIRYRLQLFRTRGMGWGVRALQDIPKGTFVCEYIGELIS 126
HMT_MBD cd01395
Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as ...
 152-212 1.27e-24

Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated transcriptional repression. SETDB1 and other proteins in this group have a similar domain architecture. SETDB1 is a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.


Pssm-ID: 238689  Cd Length: 60  Bit Score: 96.68  E-value: 1.27e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958681673 152 PLQLPLRCHFQRRHAKTNSPSAALHVNYRTPCGRSLRNMEEVFHYLLETeCNFLFTDNFSF 212
Cdd:cd01395     1 PLHTPLLCGFQRMKYRARVGKVKKHVIYKAPCGRSLRNMSEVHRYLRET-CSFLTVDNFSF 60
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 280-395 2.39e-24

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 101.60  E-value: 2.39e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958681673 280 CDCSEGCIDIKKCACLQLTAknakacplspdgecTGYKYKRLQRL-IPSG--IYECNLFCKCNRQmCQNRVIQHGPRVRL 356
Cdd:cd10542    25 CECTEDCHNNNPTCCPAESG--------------VKFAYDKQGRLrLPPGtpIYECNSRCKCGPD-CPNRVVQRGRKVPL 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1958681673 357 QVFK-SEKKGWGVRCLDDIDKGTFVCIYSGRLLSRATPEK 395
Cdd:cd10542    90 CIFRtSNGRGWGVKTLEDIKKGTFVMEYVGEIITSEEAER 129
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 273-389 3.60e-24

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 101.61  E-value: 3.60e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958681673 273 SSMFSDSCDCSEGCIDIKKCACLQ--LTAKNAKACPLSPDGECTGykykrlqrliPsgIYECNLFCKCNRQmCQNRVIQH 350
Cdd:cd10544    20 NEITFPGCDCKTSSCEPETCSCLRkyGPNYDDDGCLLDFDGKYSG----------P--VFECNSMCKCSES-CQNRVVQN 86

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1958681673 351 GPRVRLQVFKSEKKGWGVRCLDDIDKGTFVCIYSGRLLS 389
Cdd:cd10544    87 GLQFKLQVFKTPKKGWGLRTLEFIPKGRFVCEYAGEVIG 125
SET_EHMT1 cd10535
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 280-391 4.90e-20

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380933 [Multi-domain]  Cd Length: 231  Bit Score: 89.22  E-value: 4.90e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958681673 280 CDCSEGCIDiKKCACLQLTAKnakaCPLSPDGECtgykYKRLQRLIPSGIYECNLFCKCNRQmCQNRVIQHGPRVRLQVF 359
Cdd:cd10535    27 CVCIDDCSS-SNCMCGQLSMR----CWYDKDGRL----LPEFNMAEPPLIFECNHACSCWRN-CRNRVVQNGLRARLQLY 96

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1958681673 360 KSEKKGWGVRCLDDIDKGTFVCIYSGRLLSRA 391
Cdd:cd10535    97 RTRDMGWGVRSLQDIPPGTFVCEYVGELISDS 128
SET_EHMT2 cd10533
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 280-391 7.09e-20

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380931 [Multi-domain]  Cd Length: 239  Bit Score: 88.92  E-value: 7.09e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958681673 280 CDCSEGCIDiKKCACLQLTAKnakaCPLSPDGECtgykYKRLQRLIPSGIYECNLFCKCNRQmCQNRVIQHGPRVRLQVF 359
Cdd:cd10533    27 CTCVDDCSS-SNCLCGQLSIR----CWYDKDGRL----LQEFNKIEPPLIFECNQACSCWRN-CKNRVVQSGIKVRLQLY 96

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1958681673 360 KSEKKGWGVRCLDDIDKGTFVCIYSGRLLSRA 391
Cdd:cd10533    97 RTAKMGWGVRALQTIPQGTFICEYVGELISDA 128
Pre-SET pfam05033
Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines ...
 234-346 1.78e-18

Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilising SET domains.


Pssm-ID: 461530 [Multi-domain]  Cd Length: 99  Bit Score: 80.54  E-value: 1.78e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958681673 234 ISNGVESVSISFCNEVDNSKLP-QFKYRTTVWpraYHLNVSSMFSDSCDCsEGCIDiKKCACLQLTaknakacplsPDGE 312
Cdd:pfam05033   1 ISKGKENVPIPVVNEVDDEPPPpDFTYITSYI---YPKEFLLIIPQGCDC-GDCSS-EKCSCAQLN----------GGEF 65

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1958681673 313 CTGYKYKRLQRL-IPSGIYECNLFCKCnRQMCQNR 346
Cdd:pfam05033  66 RFPYDKDGLLVPeSKPPIYECNPLCGC-PPSCPNR 99
SET_SUV39H_Clr4-like cd20073
SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...
 256-395 1.13e-17

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.


Pssm-ID: 380999 [Multi-domain]  Cd Length: 259  Bit Score: 83.00  E-value: 1.13e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958681673 256 QFKYRTTVWPRayhlnvSSMFSDSCDCS--EGCI--DIKKCACLQLTAKNAKACPlspdgectgyKYKRLQRLIPSGIYE 331
Cdd:cd20073     8 SYRYGLGIEPP------DPLFISGCSCSklGGCDlnNPGSCQCLEDSNEKSFAYD----------EYGRVRANTGSIIYE 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958681673 332 CNLFCKCNRQmCQNRVIQHGPRVRLQVFKSEKKGWGVRCLDDIDKGTFVCIYSGRLLSRATPEK 395
Cdd:cd20073    72 CNENCDCGIN-CPNRVVQRGRKLPLEIFKTKHKGWGLRCPRFIKAGTFIGVYLGEVITQSEAEI 134
MBD cd00122
MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of ...
 152-212 2.70e-17

MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding protein which binds specifically to methylated DNA. The MBD can recognize a single symmetrically methylated CpG either as naked DNA or within chromatin. MeCP2, MBD1 and MBD2 (and likely MBD3) form complexes with histone deacetylase and are involved in histone deacetylase-dependent repression of transcription. MBD4 is an endonuclease that forms a complex with the DNA mismatch-repair protein MLH1. The MBDs present in putative chromatin remodelling subunit, BAZ2A, and putative histone methyltransferase, CLLD8, represent two phylogenetically distinct groups within the MBD protein family.


Pssm-ID: 238069  Cd Length: 62  Bit Score: 75.82  E-value: 2.70e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958681673 152 PLQLPLRCHFQRRHAKTNSPSA-ALHVNYRTPCGRSLRNMEEVFHYLLETECNFLFTDNFSF 212
Cdd:cd00122     1 PLRDPLPPGWKRELVIRKSGSAgKGDVYYYSPCGKKLRSKPEVARYLEKTGPSSLDLENFSF 62
SET_SUV39H_DIM5-like cd19473
SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; ...
 329-397 8.90e-15

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; This subfamily contains Neurospora crassa DIM-5 (also termed H3-K9-HMTase dim-5, or HKMT) which functions as histone-lysine N-methyltransferase that specifically trimethylates histone H3 to form H3K9me3.


Pssm-ID: 380996 [Multi-domain]  Cd Length: 274  Bit Score: 74.66  E-value: 8.90e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958681673 329 IYECNLFCKCNrQMCQNRVIQHGPRVRLQVFK-SEKKGWGVRCLDDIDKGTFVCIYSGRLLsraTPEKTN 397
Cdd:cd19473    81 IYECHEGCACS-DDCPNRVVERGRKVPLQIFRtSDGRGWGVRSTVDIKRGQFVDCYVGEII---TPEEAQ 146
PreSET smart00468
N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal ...
 233-337 6.08e-12

N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal to some SET domains. Function is unknown. Unpublished.


Pssm-ID: 128744 [Multi-domain]  Cd Length: 98  Bit Score: 62.05  E-value: 6.08e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958681673  233 DISNGVESVSISFCNEVDNSKLP-QFKY-RTTVWPRAYHLNVSSMFSDSCDCSEGCIDIKKCACLQLTaknakacplspD 310
Cdd:smart00468   3 DISNGKENVPVPLVNEVDEDPPPpDFEYiSEYIYGQGVPIDRSPSPLVGCSCSGDCSSSNKCECARKN-----------G 71

                           90       100
                   ....*....|....*....|....*..
gi 1958681673  311 GECTGYKYKRLQRLIPSGIYECNLFCK 337
Cdd:smart00468  72 GEFAYELNGGLRLKRKPLIYECNSRCS 98
SET_SUV39H2 cd10532
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 270-395 2.26e-11

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380930 [Multi-domain]  Cd Length: 243  Bit Score: 64.14  E-value: 2.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958681673 270 LNVSSMFSDSCDCSEgcidikkcaCLQltaknAKACPLSPdGECTGYKyKRLQRLIPSG--IYECNLFCKCNRQmCQNRV 347
Cdd:cd10532    15 INLDNEATVGCDCSD---------CFF-----GKCCPAEA-GVLFAYN-EHGQLKIPPGtpIYECNSRCKCGPD-CPNRV 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1958681673 348 IQHGPRVRLQVFK-SEKKGWGVRCLDDIDKGTFVCIYSGRLLSRATPEK 395
Cdd:cd10532    78 VQKGTQYSLCIFRtSNGRGWGVKTLQKIKKNSFVMEYVGEVITSEEAER 126
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 292-395 3.92e-10

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 60.29  E-value: 3.92e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958681673 292 CACLQLTAKNAKACPLSPDGECTGYKYKRLQRLIPS-GIYECNLFCKCNRQmCQNRVIQHGPRVRLQVFKSEK-KGWGVR 369
Cdd:cd10525    24 CECQDCLSQPVGGCCPGASKHRFAYNEQGQVKVRPGlPIYECNSRCRCGPD-CPNRVVQKGIQYDLCIFRTDNgRGWGVR 102

                          90       100
                  ....*....|....*....|....*.
gi 1958681673 370 CLDDIDKGTFVCIYSGRLLSRATPEK 395
Cdd:cd10525   103 TLEKIRKNSFVMEYVGEIITSEEAER 128
MBD smart00391
Methyl-CpG binding domain; Methyl-CpG binding domain, also known as the TAM (TTF-IIP5, ARBP, ...
 150-216 4.85e-10

Methyl-CpG binding domain; Methyl-CpG binding domain, also known as the TAM (TTF-IIP5, ARBP, MeCP1) domain


Pssm-ID: 128673  Cd Length: 77  Bit Score: 55.84  E-value: 4.85e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958681673  150 ENPLQLPLRCHFQRRHA--KTNSPSAALHVNYRTPCGRSLRNMEEVFHYLLETECNFLFTDNFSFNTYV 216
Cdd:smart00391   1 GDPLRLPLPCGWRRETKqrKSGRSAGKFDVYYISPCGKKLRSKSELARYLHKNGDLSLDLECFDFNATV 69
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 354-395 1.37e-08

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 53.11  E-value: 1.37e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958681673  354 VRLQVFKSEKKGWGVRCLDDIDKGTFVCIYSGRLLSRATPEK 395
Cdd:smart00317   1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEE 42
MBD pfam01429
Methyl-CpG binding domain; The Methyl-CpG binding domain (MBD) binds to DNA that contains one ...
 149-216 1.70e-07

Methyl-CpG binding domain; The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase.


Pssm-ID: 396147 [Multi-domain]  Cd Length: 76  Bit Score: 48.51  E-value: 1.70e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958681673 149 GENPLQLPLRCHFQR--RHAKTNSPSAALHVNYRTPCGRSLRNMEEVFHYLLETECNFLFTDNFSFNTYV 216
Cdd:pfam01429   3 RKREDRLPLPPGWRReeRQRKSGSKAGKVDVFYYSPTGKKLRSKSEVARYLEANGGTSPKLEDFSFTVRS 72
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 356-407 2.23e-06

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 47.29  E-value: 2.23e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958681673 356 LQVFKSEKKGWGVRCLDDIDKGTFVCIYSGRLLSRATPEKTNIGESESEQQH 407
Cdd:cd19174     2 LERFRTEDKGWGVRTKEPIKAGQFIIEYVGEVVSEQEFRRRMIEQYHNHSHH 53
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 356-395 3.59e-06

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 46.48  E-value: 3.59e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1958681673 356 LQVFKSEKKGWGVRCLDDIDKGTFVCIYSGRLLSRATPEK 395
Cdd:cd10531     2 LELFRTEKKGWGVKAKEDIQKGEFIIEYVGEVIDKKEFKE 41
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 355-389 3.77e-05

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 43.72  E-value: 3.77e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1958681673 355 RLQVFKSEKKGWGVRCLDDIDKGTFVCIYSGRLLS 389
Cdd:cd19172     3 KVEVFRTEKKGWGLRAAEDLPKGTFVIEYVGEVLD 37
HAT_MBD cd01397
Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as ...
 153-214 3.04e-04

Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The Drosophila melanogaster toutatis protein, a putative subunit of the chromatin-remodeling complex, and other such proteins in this group share a similar domain architecture with BAZ2A, as does the Caenorhabditis elegans flectin homolog.


Pssm-ID: 238691 [Multi-domain]  Cd Length: 73  Bit Score: 39.31  E-value: 3.04e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958681673 153 LQLPLRcHFQRRHAKTNSPSAALH--VNYRTPCGRSLRNMEEVFHYLLETECNFLFTDNFSFNT 214
Cdd:cd01397     2 LRVPLE-LGWRRETRIRGLGGRIQgeVAYYAPCGKKLRQYPEVIKYLSKNGISLLSRENFSFSA 64
SET_NSD cd19173
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...
 354-392 8.52e-04

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.


Pssm-ID: 380950 [Multi-domain]  Cd Length: 142  Bit Score: 39.61  E-value: 8.52e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958681673 354 VRLQVFKSEKKGWGVRCLDDIDKGTFVCIYSGRLLSRAT 392
Cdd:cd19173     2 PPTEPFKTGDRGWGLRTKRDIKKGDFVIEYVGELIDEEE 40
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 365-425 2.21e-03

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 37.89  E-value: 2.21e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958681673 365 GWGVRCLDDIDKGTFVCIYSGR-LLSRATPEKTNIGESESEQQHTVKNSFSKKRKIEVVCSD 425
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYYDKLELRLWGPYLFTLDEDSEYCID 62
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 355-395 2.62e-03

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 38.17  E-value: 2.62e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1958681673 355 RLQVFKSEKKGWGVRCLDDIDKGTFVCIYSGRLLSRATPEK 395
Cdd:cd19175     1 KMKLVKTEKCGWGLVADEDINAGEFIIEYVGEVIDDKTCEE 41
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 346-395 6.09e-03

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 37.17  E-value: 6.09e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958681673 346 RVIQHGPRVRLQVFKSEKKGWGVRCLDDIDKGTFVCIYSGRLLSRATPEK 395
Cdd:cd10528     9 ELILSGKEEGLKVIEIDGKGRGVIATRPFEKGDFVVEYHGDLITITEAKK 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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