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Conserved domains on  [gi|1958650058|ref|XP_038948271|]
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calcium and integrin-binding protein 1 isoform X1 [Rattus norvegicus]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 10040236)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

CATH:  1.10.238.10
Gene Ontology:  GO:0005509
PubMed:  2479149|10191494
SCOP:  3001983

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 111-178 4.71e-12

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


:

Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 58.71  E-value: 4.71e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958650058 111 AFRIFDFDDDGTLDREDLSRLVNcltgegedtRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVIS 178
Cdd:cd00051     5 AFRLFDKDGDGTISADELKAALK---------SLGEGLSEEEIDEMIREVDKDGDGKIDFEEFLELMA 63
 
Name Accession Description Interval E-value
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 111-178 4.71e-12

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 58.71  E-value: 4.71e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958650058 111 AFRIFDFDDDGTLDREDLSRLVNcltgegedtRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVIS 178
Cdd:cd00051     5 AFRLFDKDGDGTISADELKAALK---------SLGEGLSEEEIDEMIREVDKDGDGKIDFEEFLELMA 63
EF-hand_7 pfam13499
EF-hand domain pair;
109-178 1.05e-08

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 49.94  E-value: 1.05e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958650058 109 HYAFRIFDFDDDGTLDREDLSRLVNCLtGEGEDTRlsasemKQLIDNILEESDIDRDGTINLSEFQHVIS 178
Cdd:pfam13499   5 KEAFKLLDSDGDGYLDVEELKKLLRKL-EEGEPLS------DEEVEELFKEFDLDKDGRISFEEFLELYS 67
PTZ00183 PTZ00183
centrin; Provisional
 83-181 1.82e-06

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 45.84  E-value: 1.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958650058  83 RDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLDREDLSRLVNCLtgeGEDtrLSASEMKQLIDnileESDI 162
Cdd:PTZ00183   67 SGKIDFEEFLDIMTKKLGERDPREEILKAFRLFDDDKTGKISLKNLKRVAKEL---GET--ITDEELQEMID----EADR 137

                          90
                  ....*....|....*....
gi 1958650058 163 DRDGTINLSEFQHVISRSP 181
Cdd:PTZ00183  138 NGDGEISEEEFYRIMKKTN 156
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
84-175 2.06e-05

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 42.86  E-value: 2.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958650058  84 DSLSFEDFL-DLLSVFSDTATPDIKShyAFRIFDFDDDGTLDREDLSRLVncltgegEDTRLSASEMKQLIDNIleesDI 162
Cdd:COG5126    48 GRISREEFVaGMESLFEATVEPFARA--AFDLLDTDGDGKISADEFRRLL-------TALGVSEEEADELFARL----DT 114

                          90
                  ....*....|...
gi 1958650058 163 DRDGTINLSEFQH 175
Cdd:COG5126   115 DGDGKISFEEFVA 127
 
Name Accession Description Interval E-value
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 111-178 4.71e-12

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 58.71  E-value: 4.71e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958650058 111 AFRIFDFDDDGTLDREDLSRLVNcltgegedtRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVIS 178
Cdd:cd00051     5 AFRLFDKDGDGTISADELKAALK---------SLGEGLSEEEIDEMIREVDKDGDGKIDFEEFLELMA 63
EF-hand_7 pfam13499
EF-hand domain pair;
109-178 1.05e-08

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 49.94  E-value: 1.05e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958650058 109 HYAFRIFDFDDDGTLDREDLSRLVNCLtGEGEDTRlsasemKQLIDNILEESDIDRDGTINLSEFQHVIS 178
Cdd:pfam13499   5 KEAFKLLDSDGDGYLDVEELKKLLRKL-EEGEPLS------DEEVEELFKEFDLDKDGRISFEEFLELYS 67
PTZ00183 PTZ00183
centrin; Provisional
 83-181 1.82e-06

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 45.84  E-value: 1.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958650058  83 RDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLDREDLSRLVNCLtgeGEDtrLSASEMKQLIDnileESDI 162
Cdd:PTZ00183   67 SGKIDFEEFLDIMTKKLGERDPREEILKAFRLFDDDKTGKISLKNLKRVAKEL---GET--ITDEELQEMID----EADR 137

                          90
                  ....*....|....*....
gi 1958650058 163 DRDGTINLSEFQHVISRSP 181
Cdd:PTZ00183  138 NGDGEISEEEFYRIMKKTN 156
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
84-175 2.06e-05

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 42.86  E-value: 2.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958650058  84 DSLSFEDFL-DLLSVFSDTATPDIKShyAFRIFDFDDDGTLDREDLSRLVncltgegEDTRLSASEMKQLIDNIleesDI 162
Cdd:COG5126    48 GRISREEFVaGMESLFEATVEPFARA--AFDLLDTDGDGKISADEFRRLL-------TALGVSEEEADELFARL----DT 114

                          90
                  ....*....|...
gi 1958650058 163 DRDGTINLSEFQH 175
Cdd:COG5126   115 DGDGKISFEEFVA 127
PTZ00184 PTZ00184
calmodulin; Provisional
 85-173 1.01e-04

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 40.90  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958650058  85 SLSFEDFLDLLSV-FSDTATPD-IKShyAFRIFDFDDDGTLDREDLSRLvncLTGEGEdtRLSASEmkqlIDNILEESDI 162
Cdd:PTZ00184   63 TIDFPEFLTLMARkMKDTDSEEeIKE--AFKVFDRDGNGFISAAELRHV---MTNLGE--KLTDEE----VDEMIREADV 131

                          90
                  ....*....|.
gi 1958650058 163 DRDGTINLSEF 173
Cdd:PTZ00184  132 DGDGQINYEEF 142
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
111-178 1.40e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 40.16  E-value: 1.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958650058 111 AFRIFDFDDDGTLDREDLSRLVNCLTGE-------GEDTRLSASEMKQLIDNILEES------------DIDRDGTINLS 171
Cdd:COG5126    10 RFDLLDADGDGVLERDDFEALFRRLWATlfseadtDGDGRISREEFVAGMESLFEATvepfaraafdllDTDGDGKISAD 89


                  ....*..
gi 1958650058 172 EFQHVIS 178
Cdd:COG5126    90 EFRRLLT 96
EFh_parvalbumin_like cd16251
EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family; The family includes ...
 84-174 1.89e-03

EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family; The family includes alpha- and beta-parvalbumins, and a group of uncharacterized calglandulin-like proteins. Parvalbumins are small, acidic, cytosolic EF-hand-containing Ca2+-buffer and Ca2+ transporter/shuttle proteins belonging to EF-hand superfamily. They are expressed by vertebrates in fast-twitch muscle cells, specific neurons of the central and peripheral nervous system, sensory cells of the mammalian auditory organ (Corti's cell), and some other cells, and characterized by the presence of three consecutive EF-hand motifs (helix-loop-helix) called AB, CD, and EF, but only CD and EF can chelate metal ions, such as Ca2+ and Mg2+. Thus, they may play an additional role in Mg2+ handling. Moreover, parvalbumins represent one of the major animal allergens. In metal-bound states, parvalbumins possess a rigid and stable tertiary structure and display strong allergenicity. In contrast, the metal-free parvalbumins are intrinsically disordered, and the loss of metal ions results in a conformational change that decreases their IgE binding capacity. Furthermore, parvalbumins have been widely used as a neuronal marker for a variety of functional brain systems. They also function as a Ca2+ shuttle transporting Ca2+ from troponin-C (TnC) to the sarcoplasmic reticulum (SR) Ca2+ pump during muscle relaxation. Thus they may facilitate myocardial relaxation and play important roles in cardiac diastolic dysfunction. Parvalbumins consists of alpha- and beta- sublineages, which can be distinguished on the basis of isoelectric point (pI > 5 for alpha; pI


Pssm-ID: 319994 [Multi-domain]  Cd Length: 101  Bit Score: 36.36  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958650058  84 DSLSFEDFLDLLSVFSDTATpDIKShyAFRIFDFDDDGTLDREDLSRLVNCLTGEGEDtrLSASEMKQLidniLEESDID 163
Cdd:cd16251    15 GSFNYKKFFEHVGLKQKSED-QIKK--VFQILDKDKSGFIEEEELKYILKGFSIAGRD--LTDEETKAL----LAAGDTD 85

                          90
                  ....*....|.
gi 1958650058 164 RDGTINLSEFQ 174
Cdd:cd16251    86 GDGKIGVEEFA 96
EF-hand_6 pfam13405
EF-hand domain;
109-135 9.90e-03

EF-hand domain;


Pssm-ID: 463869 [Multi-domain]  Cd Length: 30  Bit Score: 32.53  E-value: 9.90e-03
                          10        20
                  ....*....|....*....|....*..
gi 1958650058 109 HYAFRIFDFDDDGTLDREDLSRLVNCL 135
Cdd:pfam13405   3 REAFKLFDKDGDGKISLEELRKALRSL 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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