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Conserved domains on  [gi|1958676719|ref|XP_038948145|]
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GAS2-like protein 1 isoform X2 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 18-152 4.49e-75

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


:

Pssm-ID: 409117  Cd Length: 142  Bit Score: 225.66  E-value: 4.49e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676719  18 PFRSSEAYVEAMKEDLADWLNALYSLGLpgSGDGFLTGLATGTTLCQHANAVTKA---------ARALAAARPTRGVAFQ 88
Cdd:cd21268     1 PFKSSEEYLYAMKEDLAEWLNTLYNLDI--TADNFFEKLETGVLLCKHANNVTRAarefqaqhpERASPLKLPPREVIFY 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958676719  89 AHSVAPGSFMARDNVASFIGWCRAELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLGL 152
Cdd:cd21268    79 RPSAKPGSFQARDNVSNFINWCRQLLGIPEVLLFETDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 208-276 1.06e-45

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


:

Pssm-ID: 460480  Cd Length: 69  Bit Score: 148.13  E-value: 1.06e-45
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958676719 208 LDELVREILGKCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRNHVMVRVGGGWDTLEHYLDKHDPCRC 276
Cdd:pfam02187   1 LDDEVRRIVAQCTCPTKFPVEKVGEGKYRFGDSQKLVFVRILRSHVMVRVGGGWDTLEEYLLKHDPCRA 69
 
Name Accession Description Interval E-value
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 18-152 4.49e-75

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409117  Cd Length: 142  Bit Score: 225.66  E-value: 4.49e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676719  18 PFRSSEAYVEAMKEDLADWLNALYSLGLpgSGDGFLTGLATGTTLCQHANAVTKA---------ARALAAARPTRGVAFQ 88
Cdd:cd21268     1 PFKSSEEYLYAMKEDLAEWLNTLYNLDI--TADNFFEKLETGVLLCKHANNVTRAarefqaqhpERASPLKLPPREVIFY 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958676719  89 AHSVAPGSFMARDNVASFIGWCRAELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLGL 152
Cdd:cd21268    79 RPSAKPGSFQARDNVSNFINWCRQLLGIPEVLLFETDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 208-276 1.06e-45

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


Pssm-ID: 460480  Cd Length: 69  Bit Score: 148.13  E-value: 1.06e-45
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958676719 208 LDELVREILGKCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRNHVMVRVGGGWDTLEHYLDKHDPCRC 276
Cdd:pfam02187   1 LDDEVRRIVAQCTCPTKFPVEKVGEGKYRFGDSQKLVFVRILRSHVMVRVGGGWDTLEEYLLKHDPCRA 69
GAS2 smart00243
Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
 206-278 1.57e-41

Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain


Pssm-ID: 128539  Cd Length: 73  Bit Score: 137.58  E-value: 1.57e-41
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958676719  206 RNLDELVREILGKCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRNHVMVRVGGGWDTLEHYLDKHDPCRCTS 278
Cdd:smart00243   1 DKIDDEVKRIVEDCKCPTKFQVEKISEGKYRFGDSQILRLVRILRSTVMVRVGGGWETLDEYLLKHDPCRAKG 73
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 27-149 1.28e-12

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 63.07  E-value: 1.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676719  27 EAMKEDLADWLNALYSLGLPGSG-DGFLTGLATGTTLCQHANAVtkaaralaaarptRGVAFQAHSVAPGSFMARDNVAS 105
Cdd:pfam00307   1 LELEKELLRWINSHLAEYGPGVRvTNFTTDLRDGLALCALLNKL-------------APGLVDKKKLNKSEFDKLENINL 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1958676719 106 FIGWCRAELGVPEVLMfETEDLVLRKNeKSVVLCLLEVARRGAR 149
Cdd:pfam00307  68 ALDVAEKKLGVPKVLI-EPEDLVEGDN-KSVLTYLASLFRRFQA 109
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 31-140 6.49e-10

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 55.40  E-value: 6.49e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676719   31 EDLADWLNALYSLGLPGSGDGFLTGLATGTTLCQHANAVTKAARALAAARPtrgvafqahsvAPGSFMARDNVASFIGWC 110
Cdd:smart00033   1 KTLLRWVNSLLAEYDKPPVTNFSSDLKDGVALCALLNSLSPGLVDKKKVAA-----------SLSRFKKIENINLALSFA 69

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1958676719  111 RAELGVPEvlMFETEDLVL-RKNEKSVVLCL 140
Cdd:smart00033  70 EKLGGKVV--LFEPEDLVEgPKLILGVIWTL 98
SCP1 COG5199
Calponin [Cytoskeleton];
97-149 4.49e-06

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 46.07  E-value: 4.49e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958676719  97 FMARDNVASFIGWCRaELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGAR 149
Cdd:COG5199    67 FVQMENISSFINGLK-KLRVPEYELFQTNDLFEAKDLRQVVICLYSLSRYAQK 118
 
Name Accession Description Interval E-value
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 18-152 4.49e-75

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409117  Cd Length: 142  Bit Score: 225.66  E-value: 4.49e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676719  18 PFRSSEAYVEAMKEDLADWLNALYSLGLpgSGDGFLTGLATGTTLCQHANAVTKA---------ARALAAARPTRGVAFQ 88
Cdd:cd21268     1 PFKSSEEYLYAMKEDLAEWLNTLYNLDI--TADNFFEKLETGVLLCKHANNVTRAarefqaqhpERASPLKLPPREVIFY 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958676719  89 AHSVAPGSFMARDNVASFIGWCRAELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLGL 152
Cdd:cd21268    79 RPSAKPGSFQARDNVSNFINWCRQLLGIPEVLLFETDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
CH_GAS2-like cd21204
calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth ...
 23-151 4.51e-49

calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth arrest-specific protein 2 (GAS-2) family includes GAS-2, and GAS-2 like proteins, GAS2L1-3. GAS-2 may play a role in apoptosis by acting as a cell death substrate for caspases. GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2) may be involved in the cross-linking of microtubules and microfilaments. GAS2L3, also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. Members of this family contain a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409053  Cd Length: 131  Bit Score: 158.97  E-value: 4.51e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676719  23 EAYVEAMKEDLADWLNALysLGLPGSGDGFLTGLATGTTLCQHANAVTK-----AARALAAARPTRGVAFQAHSVAPGSF 97
Cdd:cd21204     1 EEALLPMKEDLAEWLNDL--LGDDLTPDNFLDELRNGVVLCQLAQKIQEaaekaREAGKKNGPPPSYKLKCNENAKPGSF 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958676719  98 MARDNVASFIGWCRaELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLG 151
Cdd:cd21204    79 FARDNVANFLRWCR-KLGVDEVLLFESEDLVLHKNPRQVLLCLLELARIAARYG 131
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 208-276 1.06e-45

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


Pssm-ID: 460480  Cd Length: 69  Bit Score: 148.13  E-value: 1.06e-45
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958676719 208 LDELVREILGKCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRNHVMVRVGGGWDTLEHYLDKHDPCRC 276
Cdd:pfam02187   1 LDDEVRRIVAQCTCPTKFPVEKVGEGKYRFGDSQKLVFVRILRSHVMVRVGGGWDTLEEYLLKHDPCRA 69
GAS2 smart00243
Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
 206-278 1.57e-41

Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain


Pssm-ID: 128539  Cd Length: 73  Bit Score: 137.58  E-value: 1.57e-41
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958676719  206 RNLDELVREILGKCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRNHVMVRVGGGWDTLEHYLDKHDPCRCTS 278
Cdd:smart00243   1 DKIDDEVKRIVEDCKCPTKFQVEKISEGKYRFGDSQILRLVRILRSTVMVRVGGGWETLDEYLLKHDPCRAKG 73
CH_GAS2 cd21267
calponin homology (CH) domain found in growth arrest-specific protein 2; Growth ...
 23-152 1.20e-25

calponin homology (CH) domain found in growth arrest-specific protein 2; Growth arrest-specific protein 2 (GAS-2) may play a role in apoptosis by acting as a cell death substrate for caspases. It contains a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409116  Cd Length: 136  Bit Score: 98.86  E-value: 1.20e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676719  23 EAYVEAMKEDLADWLNALysLGLPGSGDGFLTGLATGTTLCQHANAVTK-------AARALAAARPTRGVAFQAHsvAP- 94
Cdd:cd21267     2 EASLLPMKEDLALWLTNL--LGKEITAESFMEKLDNGALLCQLAETLQEkfkensaDANKPGKSLPVRKIPCRAN--APs 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958676719  95 GSFMARDNVASFIGWCRaELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLGL 152
Cdd:cd21267    78 GSFFARDNTANFLSWCR-DVGVGDTCLFESEGLVLHKQPREVCLCLLELGRIAARFGV 134
CH_GAS2L3 cd21269
calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth ...
 23-151 8.17e-25

calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth arrest-specific protein 2-like 3 (GAS2L3), also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. It contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409118  Cd Length: 130  Bit Score: 96.45  E-value: 8.17e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676719  23 EAYVEAMKEDLADWLNALysLGLPGSGDGFLTGLATGTTLCQ-----HANAVTKAARALAAARPTRGVAFQAHSvAPGSF 97
Cdd:cd21269     1 EATLVPMQEDLSIWLSGM--LGKEVKAERFMEELDNGVLLCQligvlQSKIKECCSTEELKHFPMRKVPCKKDA-PSGSF 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958676719  98 MARDNVASFIGWCRAeLGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLG 151
Cdd:cd21269    78 FARDNTANFLSWCRA-IGVDETYLFESEGLVLHKDPRQVCLCLLEIGRIVSRYG 130
CH_SF cd00014
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
 30-145 7.63e-15

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


Pssm-ID: 409031 [Multi-domain]  Cd Length: 103  Bit Score: 68.90  E-value: 7.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676719  30 KEDLADWLNALYSLGLPGSGDGFLTGLATGTTLCQHANAVTKAARALAAARPTRgvafqahsvapgSFMARDNVASFIGW 109
Cdd:cd00014     1 EEELLKWINEVLGEELPVSITDLFESLRDGVLLCKLINKLSPGSIPKINKKPKS------------PFKKRENINLFLNA 68

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1958676719 110 CRaELGVPEVLMFETEDLVLRKNEKSVVLCLLEVAR 145
Cdd:cd00014    69 CK-KLGLPELDLFEPEDLYEKGNLKKVLGTLWALAL 103
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 27-149 1.28e-12

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 63.07  E-value: 1.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676719  27 EAMKEDLADWLNALYSLGLPGSG-DGFLTGLATGTTLCQHANAVtkaaralaaarptRGVAFQAHSVAPGSFMARDNVAS 105
Cdd:pfam00307   1 LELEKELLRWINSHLAEYGPGVRvTNFTTDLRDGLALCALLNKL-------------APGLVDKKKLNKSEFDKLENINL 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1958676719 106 FIGWCRAELGVPEVLMfETEDLVLRKNeKSVVLCLLEVARRGAR 149
Cdd:pfam00307  68 ALDVAEKKLGVPKVLI-EPEDLVEGDN-KSVLTYLASLFRRFQA 109
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 31-140 6.49e-10

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 55.40  E-value: 6.49e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676719   31 EDLADWLNALYSLGLPGSGDGFLTGLATGTTLCQHANAVTKAARALAAARPtrgvafqahsvAPGSFMARDNVASFIGWC 110
Cdd:smart00033   1 KTLLRWVNSLLAEYDKPPVTNFSSDLKDGVALCALLNSLSPGLVDKKKVAA-----------SLSRFKKIENINLALSFA 69

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1958676719  111 RAELGVPEvlMFETEDLVL-RKNEKSVVLCL 140
Cdd:smart00033  70 EKLGGKVV--LFEPEDLVEgPKLILGVIWTL 98
CH_SCP1-like cd21210
calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar ...
 51-145 5.09e-09

calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar proteins; The family includes transgelins from Saccharomyces cerevisiae and Schizosaccharomyces pombe, which are also called SCP1 and STG1, respectively. Transgelin, also called calponin homolog 1, has actin-binding and actin-bundling activity. It stabilizes actin filaments against disassembly. Transgelin contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409059 [Multi-domain]  Cd Length: 101  Bit Score: 52.75  E-value: 5.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676719  51 GFLTGLATGTTLCQHANAVtkaaralaaaRPTRGVAFQAhSVAPgsFMARDNVASFIGWCRAeLGVPEVLMFETEDLVLR 130
Cdd:cd21210    21 DLLDALKDGVVLCKLANRI----------LPADIRKYKE-SKMP--FVQMENISAFLNAARK-LGVPENDLFQTVDLFER 86

                          90
                  ....*....|....*
gi 1958676719 131 KNEKSVVLCLLEVAR 145
Cdd:cd21210    87 KNPAQVLQCLHALSR 101
CH_dMP20-like cd21207
calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 ...
 35-145 4.08e-07

calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 (dMP20) and similar domains; This subfamily contains Drosophila melanogaster muscle-specific protein 20 (dMP20), Echinococcus granulosus myophilin, Dictyostelium discoideum Rac guanine nucleotide exchange factor B (also called Trix), and similar proteins. dMP20 is present only in the synchronous muscles of D. melanogaster. It may be involved in the system linking the nerve impulse with the contraction or the relaxation process. Trix is involved in the regulation of the late steps of the endocytic pathway. dMP20 contains a single copy of the CH domain, while Trix (triple CH-domain array exchange factor) contains three, two type 3 CH domains which are included in this model, and one type 1 CH domain that is not included in this subfamily, but is part of the superfamily. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409056 [Multi-domain]  Cd Length: 107  Bit Score: 47.69  E-value: 4.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676719  35 DWLNALYSLGLPgSGDGFLTGLATGTTLCQHANavtkaaralaaarptrgvafqahSVAPGS----------FMARDNVA 104
Cdd:cd21207    12 DWIEAVTGEKLD-DGKDYEDVLKDGVILCKLIN-----------------------ILKPGSvkkintskmaFKLMENIE 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1958676719 105 SFIGWCRaELGVPEVLMFETEDLVLRKNEKSVVLCLLEVAR 145
Cdd:cd21207    68 NFLTACK-GYGVPKTDLFQTVDLYEKKNIPQVTNCLFALGR 107
CH_IQGAP cd21206
calponin homology (CH) domain found in the IQ motif containing GTPase activating protein ...
 35-140 4.56e-07

calponin homology (CH) domain found in the IQ motif containing GTPase activating protein family; Members of the IQ motif containing GTPase activating protein (IQGAP) family are associated with the Ras GTP-binding protein and act as essential regulators of cytoskeletal function. There are three known IQGAP family members: IQGAP1, IQGAP2, and IQGAP3. They are multi-domain molecules having a calponin-homology (CH) domain which binds F-actin, IQGAP-specific repeats, a single WW domain, four IQ motifs that mediate interactions with calmodulin, and a RasGAP related domain that binds active Rho family GTPases. IQGAP1 negatively regulates Ras family GTPases by stimulating their intrinsic GTPase activity. It lacks GAP activity. Both IQGAP1 and IQGAP2 specifically bind to Cdc42 and Rac1, but not to RhoA. Despite similarities to part of the sequence of RasGAP, neither IQGAP1 nor IQGAP2 interacts with Ras. IQGAP3 regulates the organization of the cytoskeleton under the regulation of Rac1 and Cdc42 in neuronal cells. The depletion of IQGAP3 is shown to impair neurite or axon outgrowth in neuronal cells with disorganized cytoskeleton.


Pssm-ID: 409055 [Multi-domain]  Cd Length: 118  Bit Score: 47.61  E-value: 4.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676719  35 DWLNALYSLGLPgSGDGFLTGLATGTTLCQHANAVtkaaralaaarptrgvafqAHSVAPG--------SFMARDNVASF 106
Cdd:cd21206    15 QWIEACLNEELP-PTTEFEEELRNGVVLAKLANKF-------------------APKLVPLkkiydvglQFRHTDNINHF 74

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1958676719 107 IGWCRaELGVPEVLMFETEDLVLRKNEKSVVLCL 140
Cdd:cd21206    75 LRALK-KIGLPKIFHFETTDLYEKKNIPKVIYCL 107
SCP1 COG5199
Calponin [Cytoskeleton];
97-149 4.49e-06

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 46.07  E-value: 4.49e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958676719  97 FMARDNVASFIGWCRaELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGAR 149
Cdd:COG5199    67 FVQMENISSFINGLK-KLRVPEYELFQTNDLFEAKDLRQVVICLYSLSRYAQK 118
CH_LMO7-like cd21208
calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This ...
 50-146 3.65e-03

calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This family includes LIM domain only protein 7 (LMO-7) and LIM and calponin homology domains-containing protein 1 (LIMCH1), and similar proteins. LMO-7, also called F-box only protein 20, or LOMP, is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy (EDMD)-relevant genes. It binds to alpha-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. LIMCH1 acts as an actin stress fiber-associated protein that activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. It positively regulates actin stress fiber assembly and stabilizes focal adhesions, and therefore negatively regulates cell spreading and cell migration. Members of this family contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409057 [Multi-domain]  Cd Length: 119  Bit Score: 36.55  E-value: 3.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958676719  50 DGFLTGLATGTTLCQHANAVtkaaralaaarptRGVAFQAHSVAPGSFMARDNVASFIGWCRaELGVPEVLMFETEDLVL 129
Cdd:cd21208    20 DDFRESLEDGILLCELINAI-------------KPGSIKKINRLPTPIAGLDNLNLFLKACE-DLGLKDSQLFDPTDLQD 85

                          90
                  ....*....|....*..
gi 1958676719 130 RKNEKSVVLCLLEVARR 146
Cdd:cd21208    86 LSNRRIATHVRKKEDER 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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