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Conserved domains on  [gi|1958675686|ref|XP_038947743|]
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volume-regulated anion channel subunit LRRC8B isoform X1 [Rattus norvegicus]

Protein Classification

ATP-binding protein; disease resistance protein; TIR-NBS-LRR class disease resistance protein; leucine-rich repeat domain-containing protein; leucine-rich repeat domain-containing protein; InlB B-repeat-containing protein; leucine-rich repeat domain-containing protein; TIR-NBS-LRR class disease resistance protein; leucine-rich repeat domain-containing protein; leucine-rich repeat domain-containing protein; TIR-NBS-LRR class disease resistance protein; TIR-NBS-LRR class disease resistance protein; TIR-NBS-LRR class disease resistance protein; leucine-rich repeat domain-containing protein; leucine-rich repeat domain-containing protein; TIR-NBS-LRR class disease resistance protein; leucine-rich repeat domain-containing protein; leucine-rich repeat domain-containing protein; leucine-rich repeat-containing serine/threonine-protein kinase; TIR-NBS-LRR class disease resistance protein; TIR-NBS-LRR class disease resistance protein; leucine-rich repeat domain-containing protein; leucine-rich repeat domain-containing protein( domain architecture ID 13782616)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain, similar to Saccharomyces cerevisiae checkpoint protein RAD24 and Arabidopsis thaliana disease resistance protein RPS5; ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain, similar to magnesium-chelatase subunit ChlI and RuvB-like helicase 1; disease resistance protein contains an N-terminal NB-ARC (also termed nucleotide-binding site, NBS) domain, which is a motif shared by plant and animal proteins whose activation results in cell death; also contains C-terminal leucine-rich repeat (LRR) motifs; TIR (toll/interleukin-1 receptor)-NBS (nucleotide binding site)-LRR (leucine-rich repeat) class disease resistance protein such as Arabidopsis thaliana SNC1 from and Vitis rotundifolia RPV1; resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Caenorhabditis elegans acidic leucine-rich nuclear phosphoprotein 32-related protein 2; InlB B-repeat-containing protein similar to Listeria monocytogenes invasion protein Internalin B (InlB); leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; TIR (toll/interleukin-1 receptor)-NBS (nucleotide binding site)-LRR (leucine-rich repeat) class disease resistance protein such as Arabidopsis thaliana SNC1 from and Vitis rotundifolia RPV1; resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; TIR (toll/interleukin-1 receptor)-NBS (nucleotide binding site)-LRR (leucine-rich repeat) class disease resistance protein such as Arabidopsis thaliana SNC1 from and Vitis rotundifolia RPV1; resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction; TIR (toll/interleukin-1 receptor)-NBS (nucleotide binding site)-LRR (leucine-rich repeat) class disease resistance protein such as Arabidopsis thaliana SNC1 from and Vitis rotundifolia RPV1; resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction; TIR (toll/interleukin-1 receptor)-NBS (nucleotide binding site)-LRR (leucine-rich repeat) class disease resistance protein such as Arabidopsis thaliana SNC1 from and Vitis rotundifolia RPV1; resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; TIR (toll/interleukin-1 receptor)-NBS (nucleotide binding site)-LRR (leucine-rich repeat) class disease resistance protein such as Arabidopsis thaliana SNC1 from and Vitis rotundifolia RPV1; resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Caenorhabditis elegans acidic leucine-rich nuclear phosphoprotein 32-related protein 2; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Homo sapiens leucine-rich repeat-containing protein 1 that may form a complex with DLG1 and ERBIN, where interaction between LRRC1 and ERBIN is indirect; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Homo sapiens lumican that binds to laminin; leucine-rich repeat (LRR)-containing serine/threonine-protein kinase catalyzes the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates; TIR (toll/interleukin-1 receptor)-NBS (nucleotide binding site)-LRR (leucine-rich repeat) class disease resistance protein such as Arabidopsis thaliana SNC1 from and Vitis rotundifolia RPV1; resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction; TIR (toll/interleukin-1 receptor)-NBS (nucleotide binding site)-LRR (leucine-rich repeat) class disease resistance protein such as Arabidopsis thaliana SNC1 from and Vitis rotundifolia RPV1; resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-334 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


:

Pssm-ID: 463622  Cd Length: 345  Bit Score: 532.97  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686   1 MITLTELKCLADAQSSYHILKPWWDVFWYYLTLIMLLVAVLAGALQLTQSRVLC-----CLPCKVEFDNHCAVPWDLLKA 75
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVClpcleSPPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686  76 SENTSSNSGLPLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVSI 155
Cdd:pfam12534  81 APTVSSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 156 LHKCFDSPWTTRALSETVAEQSVRPLKLSKSKTLL-----STSGGSADIDASKQSLPYPQPGLESPGIE-SPTSSVLDKK 229
Cdd:pfam12534 161 LGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLpkvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 230 EGEQAKAIFEKVKRFRLHVEQRDIIYRVYLKQIIVKVILFVLIITYVPYFLSYITLEIDCSIDVQAFTGYKRYQCVYSLA 309
Cdd:pfam12534 241 EGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLA 320

                         330       340
                  ....*....|....*....|....*
gi 1958675686 310 EIFKVLASFYVILVMLYGLTSSYSL 334
Cdd:pfam12534 321 FLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
560-802 3.52e-34

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.83  E-value: 3.52e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 560 LPSLQKLSLDNegsklvvLNNLKKMVNLKSLELLSCDLERIPHSIFSLNNLHELDLKENNLKTVEEiiSFQHLPSLSCLK 639
Cdd:COG4886    95 LTNLTELDLSG-------NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLGNLTNLKSLD 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 640 LWHNNIAYIPAQIGALSNLEQLYLGHNNIESLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLTNLQYFAVTNNNIEMLPD 719
Cdd:COG4886   166 LSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 720 gLFQCKKLQCLLLGRNSLTDLSPLvGELSNLTHLELIGNYLETLPVELEGCQSLKRSCLIVEDSLLNSLPLPVTERLQTC 799
Cdd:COG4886   246 -LGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323


                  ...
gi 1958675686 800 LDK 802
Cdd:COG4886   324 LLL 326
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 432-672 9.23e-06

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.46  E-value: 9.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 432 LPDNVFELTDMEVLSL---ELIPevKLPAAASQLVNLRELRVYHSSLVVDHPALAFLEENLKILRLKFTEM-GKIPRWVF 507
Cdd:PLN00113  300 IPELVIQLQNLEILHLfsnNFTG--KIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLtGEIPEGLC 377

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 508 HLKNLKELYLSGCVLPEQLssmqPEGFQDLKNLRTLYLKS-SLS-RIPQVVTDL-----------------------LPS 562
Cdd:PLN00113  378 SSGNLFKLILFSNSLEGEI----PKSLGACRSLRRVRLQDnSFSgELPSEFTKLplvyfldisnnnlqgrinsrkwdMPS 453

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 563 LQKLSL----------DNEGSKlvVLNNLKKMVNLKS----------LELLSCDLER------IPHSIFSLNNLHELDLK 616
Cdd:PLN00113  454 LQMLSLarnkffgglpDSFGSK--RLENLDLSRNQFSgavprklgslSELMQLKLSEnklsgeIPDELSSCKKLVSLDLS 531

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958675686 617 ENNLkTVEEIISFQHLPSLSCLKLWHNNIA-YIPAQIGALSNLEQLYLGHNNIE-SLP 672
Cdd:PLN00113  532 HNQL-SGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHgSLP 588
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-334 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 532.97  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686   1 MITLTELKCLADAQSSYHILKPWWDVFWYYLTLIMLLVAVLAGALQLTQSRVLC-----CLPCKVEFDNHCAVPWDLLKA 75
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVClpcleSPPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686  76 SENTSSNSGLPLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVSI 155
Cdd:pfam12534  81 APTVSSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 156 LHKCFDSPWTTRALSETVAEQSVRPLKLSKSKTLL-----STSGGSADIDASKQSLPYPQPGLESPGIE-SPTSSVLDKK 229
Cdd:pfam12534 161 LGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLpkvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 230 EGEQAKAIFEKVKRFRLHVEQRDIIYRVYLKQIIVKVILFVLIITYVPYFLSYITLEIDCSIDVQAFTGYKRYQCVYSLA 309
Cdd:pfam12534 241 EGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLA 320

                         330       340
                  ....*....|....*....|....*
gi 1958675686 310 EIFKVLASFYVILVMLYGLTSSYSL 334
Cdd:pfam12534 321 FLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
560-802 3.52e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.83  E-value: 3.52e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 560 LPSLQKLSLDNegsklvvLNNLKKMVNLKSLELLSCDLERIPHSIFSLNNLHELDLKENNLKTVEEiiSFQHLPSLSCLK 639
Cdd:COG4886    95 LTNLTELDLSG-------NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLGNLTNLKSLD 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 640 LWHNNIAYIPAQIGALSNLEQLYLGHNNIESLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLTNLQYFAVTNNNIEMLPD 719
Cdd:COG4886   166 LSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 720 gLFQCKKLQCLLLGRNSLTDLSPLvGELSNLTHLELIGNYLETLPVELEGCQSLKRSCLIVEDSLLNSLPLPVTERLQTC 799
Cdd:COG4886   246 -LGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323


                  ...
gi 1958675686 800 LDK 802
Cdd:COG4886   324 LLL 326
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 512-767 1.95e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 84.13  E-value: 1.95e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 512 LKELYLSGCVLPEQLSSMQpegFQdLKNLRTLYLKSS-LS-RIPQVVTDLLPSLQKLSLDNegsklvvlNNLKKMVNLKS 589
Cdd:PLN00113   71 VVSIDLSGKNISGKISSAI---FR-LPYIQTINLSNNqLSgPIPDDIFTTSSSLRYLNLSN--------NNFTGSIPRGS 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 590 LELL-SCDLE------RIPHSIFSLNNLHELDLKENNLktVEEI-ISFQHLPSLSCLKLWHNN-IAYIPAQIGALSNLEQ 660
Cdd:PLN00113  139 IPNLeTLDLSnnmlsgEIPNDIGSFSSLKVLDLGGNVL--VGKIpNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKW 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 661 LYLGHNNIE-SLPLQLFLCTKLHYLDLSYNHLTF-IPEEIQYLTNLQYFAVTNNNIE-MLPDGLFQCKKLQCLLLGRNSL 737
Cdd:PLN00113  217 IYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLTGpIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSL 296

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1958675686 738 TDLSP-LVGELSNLTHLELIGNYLE-TLPVEL 767
Cdd:PLN00113  297 SGEIPeLVIQLQNLEILHLFSNNFTgKIPVAL 328
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 607-758 3.78e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.43  E-value: 3.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 607 LNNLHELDLKENNLKtveEIISFQHLPSLSCLKLWHNNIAYIPaQIGALSNLEQLYLGHNNIESLPlQLFLCTKLHYLDL 686
Cdd:cd21340     1 LKRITHLYLNDKNIT---KIDNLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 687 SYNH----------------------------LTFIPEEIQYLTN-LQYFAVTNNNIEMLpDGLFQCKKLQCLLLGRN-- 735
Cdd:cd21340    76 GGNRisvveglenltnleelhienqrlppgekLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNqi 154

                         170       180
                  ....*....|....*....|....
gi 1958675686 736 -SLTDLSPLVGELSNLTHLELIGN 758
Cdd:cd21340   155 sDLEELLDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 432-672 9.23e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.46  E-value: 9.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 432 LPDNVFELTDMEVLSL---ELIPevKLPAAASQLVNLRELRVYHSSLVVDHPALAFLEENLKILRLKFTEM-GKIPRWVF 507
Cdd:PLN00113  300 IPELVIQLQNLEILHLfsnNFTG--KIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLtGEIPEGLC 377

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 508 HLKNLKELYLSGCVLPEQLssmqPEGFQDLKNLRTLYLKS-SLS-RIPQVVTDL-----------------------LPS 562
Cdd:PLN00113  378 SSGNLFKLILFSNSLEGEI----PKSLGACRSLRRVRLQDnSFSgELPSEFTKLplvyfldisnnnlqgrinsrkwdMPS 453

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 563 LQKLSL----------DNEGSKlvVLNNLKKMVNLKS----------LELLSCDLER------IPHSIFSLNNLHELDLK 616
Cdd:PLN00113  454 LQMLSLarnkffgglpDSFGSK--RLENLDLSRNQFSgavprklgslSELMQLKLSEnklsgeIPDELSSCKKLVSLDLS 531

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958675686 617 ENNLkTVEEIISFQHLPSLSCLKLWHNNIA-YIPAQIGALSNLEQLYLGHNNIE-SLP 672
Cdd:PLN00113  532 HNQL-SGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHgSLP 588
LRR_8 pfam13855
Leucine rich repeat;
633-691 2.41e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 2.41e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958675686 633 PSLSCLKLWHNNIAYI-PAQIGALSNLEQLYLGHNNIESLPLQLFLC-TKLHYLDLSYNHL 691
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
511-570 9.63e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 9.63e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958675686 511 NLKELYLSGCvlpeQLSSMQPEGFQDLKNLRTLYLKS-SLSRIPQVVTDLLPSLQKLSLDN 570
Cdd:pfam13855   2 NLRSLDLSNN----RLTSLDDGAFKGLSNLKVLDLSNnLLTTLSPGAFSGLPSLRYLDLSG 58
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-334 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 532.97  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686   1 MITLTELKCLADAQSSYHILKPWWDVFWYYLTLIMLLVAVLAGALQLTQSRVLC-----CLPCKVEFDNHCAVPWDLLKA 75
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVClpcleSPPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686  76 SENTSSNSGLPLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVSI 155
Cdd:pfam12534  81 APTVSSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 156 LHKCFDSPWTTRALSETVAEQSVRPLKLSKSKTLL-----STSGGSADIDASKQSLPYPQPGLESPGIE-SPTSSVLDKK 229
Cdd:pfam12534 161 LGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLpkvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 230 EGEQAKAIFEKVKRFRLHVEQRDIIYRVYLKQIIVKVILFVLIITYVPYFLSYITLEIDCSIDVQAFTGYKRYQCVYSLA 309
Cdd:pfam12534 241 EGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLA 320

                         330       340
                  ....*....|....*....|....*
gi 1958675686 310 EIFKVLASFYVILVMLYGLTSSYSL 334
Cdd:pfam12534 321 FLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
560-802 3.52e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.83  E-value: 3.52e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 560 LPSLQKLSLDNegsklvvLNNLKKMVNLKSLELLSCDLERIPHSIFSLNNLHELDLKENNLKTVEEiiSFQHLPSLSCLK 639
Cdd:COG4886    95 LTNLTELDLSG-------NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLGNLTNLKSLD 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 640 LWHNNIAYIPAQIGALSNLEQLYLGHNNIESLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLTNLQYFAVTNNNIEMLPD 719
Cdd:COG4886   166 LSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 720 gLFQCKKLQCLLLGRNSLTDLSPLvGELSNLTHLELIGNYLETLPVELEGCQSLKRSCLIVEDSLLNSLPLPVTERLQTC 799
Cdd:COG4886   246 -LGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323


                  ...
gi 1958675686 800 LDK 802
Cdd:COG4886   324 LLL 326
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
537-775 1.83e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 130.82  E-value: 1.83e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 537 LKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELLSCDLerIPHSIFSLNNLHELDLK 616
Cdd:COG4886    27 LLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL--GLTDLGDLTNLTELDLS 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 617 ENNlktveeiiSFQHLPSLSCLKLWHNNIAYIPAQIGALSNLEQLYLGHNNIESLPLQLFLCTKLHYLDLSYNHLTFIPE 696
Cdd:COG4886   105 GNE--------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPE 176

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958675686 697 EIQYLTNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGRNSLTDLSPLVGELSNLTHLELIGNYLETLPvELEGCQSLKR 775
Cdd:COG4886   177 ELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEE 254
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
539-789 4.88e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 114.65  E-value: 4.88e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 539 NLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELLSCDLERIPHSIFSLNNLHELDLKEN 618
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 619 NLKTVEEIISFQHLPSLSCLKLWHNNiayipaQIGALSNLEQLYLGHNNIESLPLQLFLCTKLHYLDLSYNHLTFIPEEI 698
Cdd:COG4886    82 LSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 699 QYLTNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGRNSLTDLSPLVGELSNLTHLELIGNYLETLPVELEGCQSLKRscL 778
Cdd:COG4886   156 GNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLET--L 233

                         250
                  ....*....|.
gi 1958675686 779 IVEDSLLNSLP 789
Cdd:COG4886   234 DLSNNQLTDLP 244
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
394-797 2.59e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.39  E-value: 2.59e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 394 NKLKQINLNNEWTVEKLKSKLVKNSQDKVELHLFMLNGLPDNVFELTDMEVLSLELIPEVKLPAAASQLVNLRELRvyhs 473
Cdd:COG4886    24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLT---- 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 474 SLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCvlpeQLSSMqPEGFQDLKNLRTLYLKS-SLSRI 552
Cdd:COG4886   100 ELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNN----QLTDL-PEPLGNLTNLKSLDLSNnQLTDL 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 553 PQVVTDLlPSLQKLSLDNegSKLVVL-NNLKKMVNLKSLELLSCDLERIPHSIFSLNNLHELDLKENNLKTVEEIisfQH 631
Cdd:COG4886   175 PEELGNL-TNLKELDLSN--NQITDLpEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPEL---GN 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 632 LPSLSCLKLWHNNIAYIPAqIGALSNLEQLYLGHNNIESLPLQ-LFLCTKLHYLDLSYNHLTFIPEEIQYLTNLQYFAVT 710
Cdd:COG4886   249 LTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDLKLKeLELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLL 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 711 NNNIEMLPDGLFQCKKLQCLLLGRNSLTDLSPLVGELSNLTHLELIGNYLETLPVELEGCQSLKRSCLIVEDSLLNSLPL 790
Cdd:COG4886   328 LLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLAL 407


                  ....*..
gi 1958675686 791 PVTERLQ 797
Cdd:COG4886   408 LDAVNTE 414
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
338-743 3.02e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 94.23  E-value: 3.02e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 338 LRSSLKQYSFEALREKSNYSDIPDVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLKSKLVKN 417
Cdd:COG4886    12 LLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 418 SQDKVELHLFMLNGlPDNVFELTDMEVLSLELIPEVKLPAAASQLVNLRELRVYHSSLVVDHPALAFLEeNLKILRLKFT 497
Cdd:COG4886    92 LGDLTNLTELDLSG-NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLT-NLKSLDLSNN 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 498 EMGKIPRWVFHLKNLKELYLSGCvlpeQLSSMqPEGFQDLKNLRTLYL-KSSLSRIPQVVTDlLPSLQKLSLDNegSKLV 576
Cdd:COG4886   170 QLTDLPEELGNLTNLKELDLSNN----QITDL-PEPLGNLTNLEELDLsGNQLTDLPEPLAN-LTNLETLDLSN--NQLT 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 577 VLNNLKKMVNLKSLELLSCDLERIPHSiFSLNNLHELDLKENNLKT--VEEIISFQHLPSLSCLKLWHNNIAYIPAQIGA 654
Cdd:COG4886   242 DLPELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDlkLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 655 LSNLEQLYLGHNN---IESLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLTNLQYFAVTNNNIEMLPDGLFQCKKLQCLL 731
Cdd:COG4886   321 TTLLLLLLLLKGLlvtLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGV 400

                         410
                  ....*....|..
gi 1958675686 732 LGRNSLTDLSPL 743
Cdd:COG4886   401 LLLTLALLDAVN 412
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 512-767 1.95e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 84.13  E-value: 1.95e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 512 LKELYLSGCVLPEQLSSMQpegFQdLKNLRTLYLKSS-LS-RIPQVVTDLLPSLQKLSLDNegsklvvlNNLKKMVNLKS 589
Cdd:PLN00113   71 VVSIDLSGKNISGKISSAI---FR-LPYIQTINLSNNqLSgPIPDDIFTTSSSLRYLNLSN--------NNFTGSIPRGS 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 590 LELL-SCDLE------RIPHSIFSLNNLHELDLKENNLktVEEI-ISFQHLPSLSCLKLWHNN-IAYIPAQIGALSNLEQ 660
Cdd:PLN00113  139 IPNLeTLDLSnnmlsgEIPNDIGSFSSLKVLDLGGNVL--VGKIpNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKW 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 661 LYLGHNNIE-SLPLQLFLCTKLHYLDLSYNHLTF-IPEEIQYLTNLQYFAVTNNNIE-MLPDGLFQCKKLQCLLLGRNSL 737
Cdd:PLN00113  217 IYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLTGpIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSL 296

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1958675686 738 TDLSP-LVGELSNLTHLELIGNYLE-TLPVEL 767
Cdd:PLN00113  297 SGEIPeLVIQLQNLEILHLFSNNFTgKIPVAL 328
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 607-758 3.78e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.43  E-value: 3.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 607 LNNLHELDLKENNLKtveEIISFQHLPSLSCLKLWHNNIAYIPaQIGALSNLEQLYLGHNNIESLPlQLFLCTKLHYLDL 686
Cdd:cd21340     1 LKRITHLYLNDKNIT---KIDNLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 687 SYNH----------------------------LTFIPEEIQYLTN-LQYFAVTNNNIEMLpDGLFQCKKLQCLLLGRN-- 735
Cdd:cd21340    76 GGNRisvveglenltnleelhienqrlppgekLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNqi 154

                         170       180
                  ....*....|....*....|....
gi 1958675686 736 -SLTDLSPLVGELSNLTHLELIGN 758
Cdd:cd21340   155 sDLEELLDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 455-773 1.52e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.42  E-value: 1.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 455 LPAAASQLVNLRELRVYHSSLVVDHPALAFLEENLKILRL---KFTemGKIPRWVFHLKNLKELYLSGcvlpEQLSSMQP 531
Cdd:PLN00113  228 IPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLyqnKLS--GPIPPSIFSLQKLISLDLSD----NSLSGEIP 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 532 EGFQDLKNLRTLYLKSS--LSRIPQVVTDLlPSLQKLSL-DNEGS-----------KLVVL----NNLKKMV-------- 585
Cdd:PLN00113  302 ELVIQLQNLEILHLFSNnfTGKIPVALTSL-PRLQVLQLwSNKFSgeipknlgkhnNLTVLdlstNNLTGEIpeglcssg 380

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 586 NLKSLELLSCDLE-RIPHSIFSLNNLHELDLKENNLkTVEEIISFQHLPSLSCLKLWHNNI-AYIPAQIGALSNLEQLYL 663
Cdd:PLN00113  381 NLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSF-SGELPSEFTKLPLVYFLDISNNNLqGRINSRKWDMPSLQMLSL 459

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 664 GHNNIESLPLQLFLCTKLHYLDLSYNHLT-FIPEEIQYLTNLQYFAVTNNNIE-MLPDGLFQCKKLQCLLLGRNSLTDLS 741
Cdd:PLN00113  460 ARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSGQI 539

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1958675686 742 PL-VGELSNLTHLELIGNYLE-TLPVELEGCQSL 773
Cdd:PLN00113  540 PAsFSEMPVLSQLDLSQNQLSgEIPKNLGNVESL 573
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 488-773 1.82e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.03  E-value: 1.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 488 NLKILRLKFTE-MGKIPRWVFHLKNLKELYLSGcvlpEQLSSMQPEGFQDLKNLRTLYLK-SSLS-RIPQVVTDLLpSLQ 564
Cdd:PLN00113  165 SLKVLDLGGNVlVGKIPNSLTNLTSLEFLTLAS----NQLVGQIPRELGQMKSLKWIYLGyNNLSgEIPYEIGGLT-SLN 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 565 KLSLdnegsklvVLNNLKKMV-----NLKSLELLSCDLER----IPHSIFSLNNLHELDLKENNL--KTVEEIISFQH-- 631
Cdd:PLN00113  240 HLDL--------VYNNLTGPIpsslgNLKNLQYLFLYQNKlsgpIPPSIFSLQKLISLDLSDNSLsgEIPELVIQLQNle 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 632 -------------------LPSLSCLKLWHNNIA-YIPAQIGALSNLEQLYLGHNNI-----ESL--------------- 671
Cdd:PLN00113  312 ilhlfsnnftgkipvaltsLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLtgeipEGLcssgnlfklilfsns 391

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 672 -----PLQLFLCTKLHYLDLSYNHLTF-IPEEIQYLTNLQYFAVTNNNI---------EM----------------LPDg 720
Cdd:PLN00113  392 legeiPKSLGACRSLRRVRLQDNSFSGeLPSEFTKLPLVYFLDISNNNLqgrinsrkwDMpslqmlslarnkffggLPD- 470

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958675686 721 LFQCKKLQCLLLGRNSLTDLSPL-VGELSNLTHLELIGNYLE-TLPVELEGCQSL 773
Cdd:PLN00113  471 SFGSKRLENLDLSRNQFSGAVPRkLGSLSELMQLKLSENKLSgEIPDELSSCKKL 525
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
485-795 2.80e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 70.50  E-value: 2.80e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 485 LEENLKILRLKFTEMGKIPRWVfhlknlkelylsgcvlPEQLSSM---------QPEGFQdlKNLRTLYLKSS-LSRIPQ 554
Cdd:PRK15370  176 LKNNKTELRLKILGLTTIPACI----------------PEQITTLildnnelksLPENLQ--GNIKTLYANSNqLTSIPA 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 555 VVTDllpSLQKLSLDnegsklvvLNNLKKMVN-----LKSLEL----LSCDLERIPhsifslNNLHELDLKENNLKTVEE 625
Cdd:PRK15370  238 TLPD---TIQEMELS--------INRITELPErlpsaLQSLDLfhnkISCLPENLP------EELRYLSVYDNSIRTLPA 300

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 626 iisfqHLPS-LSCLKLWHNNIAYIPAQIGAlsNLEQLYLGHNNIESLPLQLflctklhyldlsynhltfiPEEIQYLTnl 704
Cdd:PRK15370  301 -----HLPSgITHLNVQSNSLTALPETLPP--GLKTLEAGENALTSLPASL-------------------PPELQVLD-- 352

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 705 qyfaVTNNNIEMLPDGLfqCKKLQCLLLGRNSLTDLSPLVGelSNLTHLELIGNYLETLPVEL-----EGCQSLKrscLI 779
Cdd:PRK15370  353 ----VSKNQITVLPETL--PPTITTLDVSRNALTNLPENLP--AALQIMQASRNNLVRLPESLphfrgEGPQPTR---II 421

                         330
                  ....*....|....*.
gi 1958675686 780 VEDSllnslplPVTER 795
Cdd:PRK15370  422 VEYN-------PFSER 430
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 500-775 3.29e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 70.26  E-value: 3.29e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 500 GKIPRWVFHLKNLKELYLSGCVLpeqlssmqpegfqdlknlrtlylkssLSRIPQVVTDlLPSLQKLSLDNEGSKLVVLN 579
Cdd:PLN00113  154 GEIPNDIGSFSSLKVLDLGGNVL--------------------------VGKIPNSLTN-LTSLEFLTLASNQLVGQIPR 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 580 NLKKMVNLKSLELLSCDLE-RIPHSIFSLNNLHELDLKENNLktveeiisfqhlpslsclklwhnnIAYIPAQIGALSNL 658
Cdd:PLN00113  207 ELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNL------------------------TGPIPSSLGNLKNL 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 659 EQLYLGHNNIE-SLPLQLFLCTKLHYLDLSYNHLTF-IPEEIQYLTNLQYFAVTNNNIE-MLPDGLFQCKKLQCLLLGRN 735
Cdd:PLN00113  263 QYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSGeIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSN 342

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958675686 736 SLT----------------DLSP--LVGEL-------SNLTHLELIGNYLET-LPVELEGCQSLKR 775
Cdd:PLN00113  343 KFSgeipknlgkhnnltvlDLSTnnLTGEIpeglcssGNLFKLILFSNSLEGeIPKSLGACRSLRR 408
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
578-797 5.50e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 63.18  E-value: 5.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 578 LNNLKKMVNLKSLELLScdlerIPHSIfsLNNLHELDLKENNLKTVEEIISfqhlPSLSCLKLWHNNIAYIPAQIGalSN 657
Cdd:PRK15370  176 LKNNKTELRLKILGLTT-----IPACI--PEQITTLILDNNELKSLPENLQ----GNIKTLYANSNQLTSIPATLP--DT 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 658 LEQLYLGHNNIESLPLQLflCTKLHYLDLSYNHLTFIPEEIQylTNLQYFAVTNNNIEMLPDGLfqckklqclllgrnsl 737
Cdd:PRK15370  243 IQEMELSINRITELPERL--PSALQSLDLFHNKISCLPENLP--EELRYLSVYDNSIRTLPAHL---------------- 302

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958675686 738 tdlsPlvgelSNLTHLELIGNYL----ETLPVELEgcqslkrsCLIVEDSLLNSLPLPVTERLQ 797
Cdd:PRK15370  303 ----P-----SGITHLNVQSNSLtalpETLPPGLK--------TLEAGENALTSLPASLPPELQ 349
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 508-692 2.39e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.18  E-value: 2.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 508 HLKNLKELYLSGcvlpEQLSSMqpEGFQDLKNLRTLYL-KSSLSRIPQVvtDLLPSLQKLSLDneGSKLVVLNNLKkmvN 586
Cdd:cd21340    22 LCKNLKVLYLYD----NKITKI--ENLEFLTNLTHLYLqNNQIEKIENL--ENLVNLKKLYLG--GNRISVVEGLE---N 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 587 LKSLELLSCDLERIPHSifslnnlHELDLKENNLKTVeeiisfqhLPSLSCLKLWHNNIAYIpAQIGALSNLEQLYLGHN 666
Cdd:cd21340    89 LTNLEELHIENQRLPPG-------EKLTFDPRSLAAL--------SNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNN 152

                         170       180
                  ....*....|....*....|....*....
gi 1958675686 667 NIESL-PLQLFL--CTKLHYLDLSYNHLT 692
Cdd:cd21340   153 QISDLeELLDLLssWPSLRELDLTGNPVC 181
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 548-760 4.16e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 56.34  E-value: 4.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 548 SLSRIPQVVTDLLPSL--QKLSLDNEGS-KLVVLNNLKKMVNLKSLELLSCDLERIPHSIFSLNNLHELDLKENNL--KT 622
Cdd:COG5238   145 QVLKDPLGGNAVHLLGlaARLGLLAAISmAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIgdEG 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 623 VEEIIS-FQHLPSLSCLKLWHNNI--AYIPAQIGAL---SNLEQLYLGHNNI-----ESLPLQLFLCTKLHYLDLSYNHL 691
Cdd:COG5238   225 AEILAEaLKGNKSLTTLDLSNNQIgdEGVIALAEALknnTTVETLYLSGNQIgaegaIALAKALQGNTTLTSLDLSVNRI 304

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958675686 692 TFipeeiqyltnlqyfavtnNNIEMLPDGLFQCKKLQCLLLGRNSLTD-----LSPLVGELSNLTHLELIGNYL 760
Cdd:COG5238   305 GD------------------EGAIALAEGLQGNKTLHTLNLAYNGIGAqgaiaLAKALQENTTLHSLDLSDNQI 360
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 428-692 2.00e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.85  E-value: 2.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 428 MLNG-LPDNVFELTDMevLSLEL--------IPEVKLpaaasQLVNLRELRVYHSSLVVDHP-ALAFLEEnLKILRL--- 494
Cdd:PLN00113  271 KLSGpIPPSIFSLQKL--ISLDLsdnslsgeIPELVI-----QLQNLEILHLFSNNFTGKIPvALTSLPR-LQVLQLwsn 342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 495 KFTemGKIPRWVFHLKNLKELYLSgcvlPEQLSSMQPEGFQDLKNLRTLYLKS-SL-SRIPQVVTDLlPSLQKLSLDNEG 572
Cdd:PLN00113  343 KFS--GEIPKNLGKHNNLTVLDLS----TNNLTGEIPEGLCSSGNLFKLILFSnSLeGEIPKSLGAC-RSLRRVRLQDNS 415

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 573 SKLVVLNNLKKMVNLKSLELLSCDLE-RIPHSIFSLNNLHELDLKENNLktveeiisFQHLP------SLSCLKLWHNNI 645
Cdd:PLN00113  416 FSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKF--------FGGLPdsfgskRLENLDLSRNQF 487

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1958675686 646 A-YIPAQIGALSNLEQLYLGHNNIES-LPLQLFLCTKLHYLDLSYNHLT 692
Cdd:PLN00113  488 SgAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNQLS 536
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 597-777 2.67e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.05  E-value: 2.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 597 LERIPHSIFSLNNLHELDLKENNL--KTVEEIISFQHLPSLSCLKLWHNNIAYIPAQI--GAL----SNLEQLYLGHNNI 668
Cdd:cd00116    70 LQSLLQGLTKGCGLQELDLSDNALgpDGCGVLESLLRSSSLQELKLNNNGLGDRGLRLlaKGLkdlpPALEKLVLGRNRL 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 669 -----ESLPLQLFLCTKLHYLDLSYNHLTfiPEEIQYLT------------NLQYFAVTNNNIEMLPDGLFQCKKLQCLL 731
Cdd:cd00116   150 egascEALAKALRANRDLKELNLANNGIG--DAGIRALAeglkancnlevlDLNNNGLTDEGASALAETLASLKSLEVLN 227

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958675686 732 LGRNSLTD------LSPLVGELSNLTHLELIGNYLetlpvELEGCQSLKRSC 777
Cdd:cd00116   228 LGDNNLTDagaaalASALLSPNISLLTLSLSCNDI-----TDDGAKDLAEVL 274
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 432-672 9.23e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.46  E-value: 9.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 432 LPDNVFELTDMEVLSL---ELIPevKLPAAASQLVNLRELRVYHSSLVVDHPALAFLEENLKILRLKFTEM-GKIPRWVF 507
Cdd:PLN00113  300 IPELVIQLQNLEILHLfsnNFTG--KIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLtGEIPEGLC 377

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 508 HLKNLKELYLSGCVLPEQLssmqPEGFQDLKNLRTLYLKS-SLS-RIPQVVTDL-----------------------LPS 562
Cdd:PLN00113  378 SSGNLFKLILFSNSLEGEI----PKSLGACRSLRRVRLQDnSFSgELPSEFTKLplvyfldisnnnlqgrinsrkwdMPS 453

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 563 LQKLSL----------DNEGSKlvVLNNLKKMVNLKS----------LELLSCDLER------IPHSIFSLNNLHELDLK 616
Cdd:PLN00113  454 LQMLSLarnkffgglpDSFGSK--RLENLDLSRNQFSgavprklgslSELMQLKLSEnklsgeIPDELSSCKKLVSLDLS 531

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958675686 617 ENNLkTVEEIISFQHLPSLSCLKLWHNNIA-YIPAQIGALSNLEQLYLGHNNIE-SLP 672
Cdd:PLN00113  532 HNQL-SGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHgSLP 588
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 410-790 1.32e-05

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 49.10  E-value: 1.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686  410 LKSKLVKNSQDKVELHLFMLNGLPDNVFELtDMEVLSLElipevKLPAAASQLVNLRELRVYHSSLVVDHPALAfLEENL 489
Cdd:PLN03210   587 LPPKLRLLRWDKYPLRCMPSNFRPENLVKL-QMQGSKLE-----KLWDGVHSLTGLRNIDLRGSKNLKEIPDLS-MATNL 659

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686  490 KILRL-KFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLssmqPEGFqDLKNLRTLYLK--SSLSRIPQVVTDL------- 559
Cdd:PLN03210   660 ETLKLsDCSSLVELPSSIQYLNKLEDLDMSRCENLEIL----PTGI-NLKSLYRLNLSgcSRLKSFPDISTNIswldlde 734

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686  560 -----LPSlqKLSLDNegSKLVVLNNLKKMVNLKSLELLSCDLERIPHSifslnnLHELDLkENNLKTVEEIISFQHLPS 634
Cdd:PLN03210   735 taieeFPS--NLRLEN--LDELILCEMKSEKLWERVQPLTPLMTMLSPS------LTRLFL-SDIPSLVELPSSIQNLHK 803

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686  635 LSCLKLWH-NNIAYIPAQIGaLSNLEQLYLGH-NNIESLPlqlFLCTKLHYLDLSYNHLTFIPEEIQYLTNLQYFAVTN- 711
Cdd:PLN03210   804 LEHLEIENcINLETLPTGIN-LESLESLDLSGcSRLRTFP---DISTNISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGc 879

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686  712 NNIEMLPDGLFQCKKLQ------CLLLGRNSLTDLSPLVGELSNLTHLELIgnylETLPVELEGCQSLKRSCLIVEDSLL 785
Cdd:PLN03210   880 NNLQRVSLNISKLKHLEtvdfsdCGALTEASWNGSPSEVAMATDNIHSKLP----STVCINFINCFNLDQEALLQQQSIF 955


                   ....*
gi 1958675686  786 NSLPL 790
Cdd:PLN03210   956 KQLIL 960
LRR_8 pfam13855
Leucine rich repeat;
633-691 2.41e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 2.41e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958675686 633 PSLSCLKLWHNNIAYI-PAQIGALSNLEQLYLGHNNIESLPLQLFLC-TKLHYLDLSYNHL 691
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
586-645 3.37e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 3.37e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958675686 586 NLKSLELLSCDLERIPHSIFS-LNNLHELDLKENNLKTVEEiISFQHLPSLSCLKLWHNNI 645
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
702-760 1.58e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 1.58e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958675686 702 TNLQYFAVTNNNIEMLPDGLFQ-CKKLQCLLLGRNSLTDLSP--LVGeLSNLTHLELIGNYL 760
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPgaFSG-LPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
511-570 9.63e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 9.63e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958675686 511 NLKELYLSGCvlpeQLSSMQPEGFQDLKNLRTLYLKS-SLSRIPQVVTDLLPSLQKLSLDN 570
Cdd:pfam13855   2 NLRSLDLSNN----RLTSLDDGAFKGLSNLKVLDLSNnLLTTLSPGAFSGLPSLRYLDLSG 58
LRR_8 pfam13855
Leucine rich repeat;
679-737 9.92e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 9.92e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958675686 679 TKLHYLDLSYNHLTFIPEEI-QYLTNLQYFAVTNNNIEMLPDGLFQC-KKLQCLLLGRNSL 737
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 693-769 6.38e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.18  E-value: 6.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675686 693 FIPEEIQYLTNLQYFAVTNNNIE-MLPDGLFQCKKLQCLLLGRNSLTDLSP-LVGELSNLTHLELIGNYLE-TLPVELEG 769
Cdd:PLN03150  433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIPeSLGQLTSLRILNLNGNSLSgRVPAALGG 512
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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