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Conserved domains on  [gi|1958675631|ref|XP_038947719|]
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transforming growth factor beta receptor type 3 isoform X1 [Rattus norvegicus]

Protein Classification

zona pellucida domain-containing protein( domain architecture ID 12198352)

zona pellucida (ZP) domain-containing protein may function as a structural component of egg coats, appendicularian mucous houses, and nematode dauer larvae, or as a mechanotransducer in flies, or as a receptor in mammals and nonmammals

Gene Ontology:  GO:0031012

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
378-655 2.01e-50

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


:

Pssm-ID: 214579  Cd Length: 252  Bit Score: 177.19  E-value: 2.01e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675631  378 KCDHEKMVVAVDKDSFQTNGYSGMELTLLDPSCKA---KMNGTHFVLESPLNGCGTRhRRSTPDGVVYYNSIVVQAPSPG 454
Cdd:smart00241   1 QCGEDQMVVSVSTDLLFPGGINVKGLTLGDPSCRPqftDATSAFVSFEVPLNGCGTR-RQVNPDGIVYSNTLVVSPFHPG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675631  455 dssgwpdgyedLESGDNGFpgdgdegetaplsragVVVFNCSLRQLRN-----------PSGFQGQLDGNATFNMELYNT 523
Cdd:smart00241  80 -----------FITRDDRA----------------AYHFQCFYPENEKvslnldvstipPTELSSVSEGPLTCSYRLYKD 132
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675631  524 DLFLVPSPGVFsVAENEHVYVEVSVTKA-DQDLGFAIQTCFLSPYSNPDRMSDYTIIENICPKD---DSVKFYSSKRVHf 599
Cdd:smart00241 133 DSFGSPYQSAD-YVLGDPVYHEWECDGAdDPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPVDgylDSTIPYNSNPLH- 210
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958675631  600 pipHAEVDKKRFSFLfksvfNTSLLFLHCELTLCSRKKGSLklprCVTPddACTSL 655
Cdd:smart00241 211 ---RARFSVKVFKFA-----DRSLVYFHCQIRLCDKDDGSS----CDGP--ACSSR 252
 
Name Accession Description Interval E-value
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
378-655 2.01e-50

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 177.19  E-value: 2.01e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675631  378 KCDHEKMVVAVDKDSFQTNGYSGMELTLLDPSCKA---KMNGTHFVLESPLNGCGTRhRRSTPDGVVYYNSIVVQAPSPG 454
Cdd:smart00241   1 QCGEDQMVVSVSTDLLFPGGINVKGLTLGDPSCRPqftDATSAFVSFEVPLNGCGTR-RQVNPDGIVYSNTLVVSPFHPG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675631  455 dssgwpdgyedLESGDNGFpgdgdegetaplsragVVVFNCSLRQLRN-----------PSGFQGQLDGNATFNMELYNT 523
Cdd:smart00241  80 -----------FITRDDRA----------------AYHFQCFYPENEKvslnldvstipPTELSSVSEGPLTCSYRLYKD 132
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675631  524 DLFLVPSPGVFsVAENEHVYVEVSVTKA-DQDLGFAIQTCFLSPYSNPDRMSDYTIIENICPKD---DSVKFYSSKRVHf 599
Cdd:smart00241 133 DSFGSPYQSAD-YVLGDPVYHEWECDGAdDPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPVDgylDSTIPYNSNPLH- 210
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958675631  600 pipHAEVDKKRFSFLfksvfNTSLLFLHCELTLCSRKKGSLklprCVTPddACTSL 655
Cdd:smart00241 211 ---RARFSVKVFKFA-----DRSLVYFHCQIRLCDKDDGSS----CDGP--ACSSR 252
Zona_pellucida pfam00100
Zona pellucida-like domain;
379-646 7.32e-38

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 141.98  E-value: 7.32e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675631 379 CDHEKMVVAVDKDSFQTNGYSGmELTL---LDPSCKAKMNG---THFVLESPLNGCGTRhRRSTPDGVVYYNSIVVQAPS 452
Cdd:pfam00100   1 CTPDTMTVSISKCLLVPSGLLS-SLSLlggLDPSCKPVSNTngsPAVLFEFPLTGCGTT-VQVNGTHIIYSNTLYSSTDL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675631 453 PGDSSgwpdgyedlesgdngfpgdgdegetaPLSRAGVVVFNC--------SLRQLRNPSGFQGQLD--GNATFNMELYN 522
Cdd:pfam00100  79 RSGII--------------------------RRTITRRLPFSCsyprsslvSLLVVAPPSPVPITVSgsGVFLVSMDLYY 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675631 523 TDLFLVP---SPGVFSVaeNEHVYVEVSVTKA-DQDLGFAIQTCFLSPYSNPDRMSDYTIIENICPKDDSVKFYSSKRVH 598
Cdd:pfam00100 133 DSSYTSPyspYPVTVLL--GDPLYVEVSLLSRtDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTYPVSSLSN 210
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958675631 599 FPiphaeVDKKRFSF-LFKSVFNT-SLLFLHCELTLCSRKKGSLKlPRCV 646
Cdd:pfam00100 211 GP-----SHYVRFSFkAFRFVGSSiSQVYLHCSVSVCSSDSNSCG-KSCS 254
 
Name Accession Description Interval E-value
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
378-655 2.01e-50

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 177.19  E-value: 2.01e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675631  378 KCDHEKMVVAVDKDSFQTNGYSGMELTLLDPSCKA---KMNGTHFVLESPLNGCGTRhRRSTPDGVVYYNSIVVQAPSPG 454
Cdd:smart00241   1 QCGEDQMVVSVSTDLLFPGGINVKGLTLGDPSCRPqftDATSAFVSFEVPLNGCGTR-RQVNPDGIVYSNTLVVSPFHPG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675631  455 dssgwpdgyedLESGDNGFpgdgdegetaplsragVVVFNCSLRQLRN-----------PSGFQGQLDGNATFNMELYNT 523
Cdd:smart00241  80 -----------FITRDDRA----------------AYHFQCFYPENEKvslnldvstipPTELSSVSEGPLTCSYRLYKD 132
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675631  524 DLFLVPSPGVFsVAENEHVYVEVSVTKA-DQDLGFAIQTCFLSPYSNPDRMSDYTIIENICPKD---DSVKFYSSKRVHf 599
Cdd:smart00241 133 DSFGSPYQSAD-YVLGDPVYHEWECDGAdDPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPVDgylDSTIPYNSNPLH- 210
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958675631  600 pipHAEVDKKRFSFLfksvfNTSLLFLHCELTLCSRKKGSLklprCVTPddACTSL 655
Cdd:smart00241 211 ---RARFSVKVFKFA-----DRSLVYFHCQIRLCDKDDGSS----CDGP--ACSSR 252
Zona_pellucida pfam00100
Zona pellucida-like domain;
379-646 7.32e-38

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 141.98  E-value: 7.32e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675631 379 CDHEKMVVAVDKDSFQTNGYSGmELTL---LDPSCKAKMNG---THFVLESPLNGCGTRhRRSTPDGVVYYNSIVVQAPS 452
Cdd:pfam00100   1 CTPDTMTVSISKCLLVPSGLLS-SLSLlggLDPSCKPVSNTngsPAVLFEFPLTGCGTT-VQVNGTHIIYSNTLYSSTDL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675631 453 PGDSSgwpdgyedlesgdngfpgdgdegetaPLSRAGVVVFNC--------SLRQLRNPSGFQGQLD--GNATFNMELYN 522
Cdd:pfam00100  79 RSGII--------------------------RRTITRRLPFSCsyprsslvSLLVVAPPSPVPITVSgsGVFLVSMDLYY 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958675631 523 TDLFLVP---SPGVFSVaeNEHVYVEVSVTKA-DQDLGFAIQTCFLSPYSNPDRMSDYTIIENICPKDDSVKFYSSKRVH 598
Cdd:pfam00100 133 DSSYTSPyspYPVTVLL--GDPLYVEVSLLSRtDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTYPVSSLSN 210
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958675631 599 FPiphaeVDKKRFSF-LFKSVFNT-SLLFLHCELTLCSRKKGSLKlPRCV 646
Cdd:pfam00100 211 GP-----SHYVRFSFkAFRFVGSSiSQVYLHCSVSVCSSDSNSCG-KSCS 254
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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