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Conserved domains on  [gi|1958649805|ref|XP_038947332|]
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WD repeat-containing protein 74 isoform X2 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1907922)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to Schizosaccharomyces pombe ribosome biogenesis protein nsa1 involved in the biogenesis of the 60S ribosomal subunit

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  30069656|29026209|21468892
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nsa1_WDR74-like super family cl45912
Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 ...
 46-172 1.38e-56

Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi and WDR74 (WD repeat-containing protein 74) from mammals and plants, are homologous essential factors for ribosome assembly. In cooperation with the assembly factor Rix7/NVL2, Nsa1/WDR74 participates in an early cleavage of the pre-rRNA processing pathway. Rix7/NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1/WDR74 from nucleolar pre-60S particles. Nsa1/WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7/NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


The actual alignment was detected with superfamily member cd22857:

Pssm-ID: 459257 [Multi-domain]  Cd Length: 325  Bit Score: 182.43  E-value: 1.38e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649805  46 GEHQVRIYDPASpQRRPVLEATYGEYPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAG-SVRGLQCHPSK 124
Cdd:cd22857   200 GYHQVRLYDTRA-QRRPVVSVDFGETPIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCFKGKCGgSIRSIARHPEL 278

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1958649805 125 PLLASCGLDRVLRIHRIRNPRgLEHKVYLKSQLNCLLLSGRDNWEDEP 172
Cdd:cd22857   279 PLIASCGLDRYLRIWDTETRQ-LLSKVYLKQRLTAVVFDSSFSPEEEA 325
 
Name Accession Description Interval E-value
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 46-172 1.38e-56

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 182.43  E-value: 1.38e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649805  46 GEHQVRIYDPASpQRRPVLEATYGEYPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAG-SVRGLQCHPSK 124
Cdd:cd22857   200 GYHQVRLYDTRA-QRRPVVSVDFGETPIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCFKGKCGgSIRSIARHPEL 278

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1958649805 125 PLLASCGLDRVLRIHRIRNPRgLEHKVYLKSQLNCLLLSGRDNWEDEP 172
Cdd:cd22857   279 PLIASCGLDRYLRIWDTETRQ-LLSKVYLKQRLTAVVFDSSFSPEEEA 325
WD40 COG2319
WD40 repeat [General function prediction only];
48-147 8.01e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.75  E-value: 8.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649805  48 HQVRIYDPASPQRRPVLEATYGeyPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLL 127
Cdd:COG2319   268 GTVRLWDLATGELLRTLTGHSG--GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTL 345

                          90       100
                  ....*....|....*....|
gi 1958649805 128 ASCGLDRVLRIHRIRNPRGL 147
Cdd:COG2319   346 ASGSDDGTVRLWDLATGELL 365
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 101-139 9.06e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 9.06e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958649805  101 QGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIH 139
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
102-138 6.41e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.47  E-value: 6.41e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1958649805 102 GRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRI 138
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
 
Name Accession Description Interval E-value
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 46-172 1.38e-56

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 182.43  E-value: 1.38e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649805  46 GEHQVRIYDPASpQRRPVLEATYGEYPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAG-SVRGLQCHPSK 124
Cdd:cd22857   200 GYHQVRLYDTRA-QRRPVVSVDFGETPIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCFKGKCGgSIRSIARHPEL 278

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1958649805 125 PLLASCGLDRVLRIHRIRNPRgLEHKVYLKSQLNCLLLSGRDNWEDEP 172
Cdd:cd22857   279 PLIASCGLDRYLRIWDTETRQ-LLSKVYLKQRLTAVVFDSSFSPEEEA 325
Nsa1_WDR74-like cd22850
Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 ...
 48-166 1.89e-35

Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi and WDR74 (WD repeat-containing protein 74) from mammals and plants, are homologous essential factors for ribosome assembly. In cooperation with the assembly factor Rix7/NVL2, Nsa1/WDR74 participates in an early cleavage of the pre-rRNA processing pathway. Rix7/NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1/WDR74 from nucleolar pre-60S particles. Nsa1/WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7/NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439302 [Multi-domain]  Cd Length: 333  Bit Score: 127.75  E-value: 1.89e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649805  48 HQVRIYDPASpQRRPVleatYGEYPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAG-SVRGLQCHPS--K 124
Cdd:cd22850   215 GQVRLYDTSA-GRRPV----FSEKPIKKPEEDLDGHTVYVGDTSGDLALIDIRTGKLLGRLLGKYGgSITGAVRHPElfD 289

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1958649805 125 PLLASCGLDRVLRIHRIRNPRgLEHKVYLKSQ-LNCLLLSGRD 166
Cdd:cd22850   290 PYLASGGLDRYLRVFDIETRE-LLAKVYLGKQiLTVVVLDDEE 331
Nsa1 cd22858
Ribosome Biogenesis Protein Nsa1; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from ...
 49-202 4.79e-15

Ribosome Biogenesis Protein Nsa1; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi is an essential factor for ribosome assembly. In cooperation with the assembly factor Rix7, Nsa1 participates in an early cleavage of the pre-rRNA processing pathway. Rix7 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1 from nucleolar pre-60S particles. The release of Nsa1 from a discrete preribosomal particle may trigger the progression of 60S ribosome biogenesis. Nsa1 is essential for cell viability in yeast. It contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439304  Cd Length: 399  Bit Score: 73.02  E-value: 4.79e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649805  49 QVRIYDpASPQRRPVLEATYGEYPLTAMTLTpegnSVIVGNTHGQLAE-----IDFR--------QGRLLGCLKG--LAG 113
Cdd:cd22858   234 HLRKYD-TTHGRKPIKSYKLLPKPELTEPLT----ELIISDTHSLIAKlslitTDSKksvsagdgKGRLLGKYGGgdITG 308

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649805 114 SVRGLQCHPSKpLLASCGLDRVLRIHRIRNpRGLEHKVYLKSQLN-CLLLSGRDnwEDEPQEPQEPNL---VPPEDTETD 189
Cdd:cd22858   309 AVSAVDVFEDK-YLATGGLDRYLRVFDLET-RELLAKVYVGSKISsVLLLDDED--IELPESEKKKKKkkkRKEEEEEED 384

                         170
                  ....*....|....*
gi 1958649805 190 --ELWASLEAAAKRK 202
Cdd:cd22858   385 deELWNELEEKKKKR 399
WD40 COG2319
WD40 repeat [General function prediction only];
48-147 8.01e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.75  E-value: 8.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649805  48 HQVRIYDPASPQRRPVLEATYGeyPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLL 127
Cdd:COG2319   268 GTVRLWDLATGELLRTLTGHSG--GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTL 345

                          90       100
                  ....*....|....*....|
gi 1958649805 128 ASCGLDRVLRIHRIRNPRGL 147
Cdd:COG2319   346 ASGSDDGTVRLWDLATGELL 365
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-145 1.54e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.71  E-value: 1.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649805  48 HQVRIYDPASPQRRPVLEATYGeyPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLL 127
Cdd:cd00200   157 GTIKLWDLRTGKCVATLTGHTG--EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLL 234

                          90
                  ....*....|....*...
gi 1958649805 128 ASCGLDRVLRIHRIRNPR 145
Cdd:cd00200   235 ASGSEDGTIRVWDLRTGE 252
WD40 COG2319
WD40 repeat [General function prediction only];
30-145 3.26e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.21  E-value: 3.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649805  30 ARSIPFTVVPQATDTMGE-HQVRIYDPASPQRRPVLEATYGeyPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCL 108
Cdd:COG2319    81 VLSVAFSPDGRLLASASAdGTVRLWDLATGLLLRTLTGHTG--AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1958649805 109 KGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRNPR 145
Cdd:COG2319   159 TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 72-145 4.17e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.56  E-value: 4.17e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958649805  72 PLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRNPR 145
Cdd:cd00200    11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84
WD40 COG2319
WD40 repeat [General function prediction only];
48-145 5.31e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 5.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649805  48 HQVRIYDPASPQRRPVLEAtyGEYPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLL 127
Cdd:COG2319   142 GTVRLWDLATGKLLRTLTG--HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLL 219

                          90
                  ....*....|....*...
gi 1958649805 128 ASCGLDRVLRIHRIRNPR 145
Cdd:COG2319   220 ASGSADGTVRLWDLATGK 237
WD40 COG2319
WD40 repeat [General function prediction only];
50-143 9.23e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.67  E-value: 9.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649805  50 VRIYDPASPQRRPVLEAtyGEYPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLLAS 129
Cdd:COG2319   312 VRLWDLATGKLLRTLTG--HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLAS 389

                          90
                  ....*....|....
gi 1958649805 130 CGLDRVLRIHRIRN 143
Cdd:COG2319   390 GSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
48-145 1.09e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.67  E-value: 1.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649805  48 HQVRIYDPASPQRRPVLEAtyGEYPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLL 127
Cdd:COG2319   184 GTVRLWDLATGKLLRTLTG--HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLL 261

                          90
                  ....*....|....*...
gi 1958649805 128 ASCGLDRVLRIHRIRNPR 145
Cdd:COG2319   262 ASGSADGTVRLWDLATGE 279
WD40 COG2319
WD40 repeat [General function prediction only];
48-138 5.58e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.36  E-value: 5.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649805  48 HQVRIYDPASPQRRPVLEAtyGEYPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLL 127
Cdd:COG2319   226 GTVRLWDLATGKLLRTLTG--HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLL 303

                          90
                  ....*....|.
gi 1958649805 128 ASCGLDRVLRI 138
Cdd:COG2319   304 ASGSDDGTVRL 314
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 49-138 7.91e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.71  E-value: 7.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649805  49 QVRIYDPASPQrrpvLEATYG--EYPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPL 126
Cdd:cd00200   200 TIKLWDLSTGK----CLGTLRghENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR 275

                          90
                  ....*....|..
gi 1958649805 127 LASCGLDRVLRI 138
Cdd:cd00200   276 LASGSADGTIRI 287
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 101-139 9.06e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 9.06e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958649805  101 QGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIH 139
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 98-145 3.64e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 37.70  E-value: 3.64e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1958649805  98 DFRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRNPR 145
Cdd:cd00200    79 DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK 126
WD40 pfam00400
WD domain, G-beta repeat;
102-138 6.41e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.47  E-value: 6.41e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1958649805 102 GRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRI 138
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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