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Conserved domains on  [gi|1958674137|ref|XP_038947284|]
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regulator of G-protein signaling protein-like isoform X1 [Rattus norvegicus]

Protein Classification

regulator of G-protein signaling domain-containing protein; G protein-coupled receptor kinase( domain architecture ID 10171662)

regulator of G-protein signaling (RGS) domain-containing protein belongs to a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs)| G protein-coupled receptor kinase is a serine/threonine-protein kinase that phosphorylate and regulate G protein-coupled receptors (GPCRs)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RGS-like_2 cd08728
Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These ...
 713-891 1.11e-87

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These uncharacterized RGS-like domains consists largely of hypothetical proteins. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play an important role in neuronal signal modulation. Some RGS proteins are the principal elements needed for proper vision.


:

Pssm-ID: 188683  Cd Length: 179  Bit Score: 280.57  E-value: 1.11e-87
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674137  713 LLNNAHLEYFREFLKDRKSENPLQFLIAVQKIMMETNEKTYKTSLENITKTYLHGKVPPEEILQCDAPFVKEVVNTRHIT 792
Cdd:cd08728      1 LRNHTHLEYFKRFLKSRGSDGPLLFWIAVEKMRVEENEKEQKAKIELIVKRYFHGQDPPGVLLQCEAIIIREIAMMKVVT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674137  793 TTTLLMLQGIIMKSVEEKWFKEYQDLFPPRPVEVEPVETHVVPRKPSKTITTHLHDSQKRGWIKMISFIKSFCKYRRFVT 872
Cdd:cd08728     81 TSMLLSIQHLVSKSLEERWFKKYQDTFPDCPHEVEPDEEIKVPLKPTKLKAPHVISSQKRAWEIFISFIRSFIKFRRFMV 160

                          170
                   ....*....|....*....
gi 1958674137  873 NAKNLQELTDFIYLEMYNN 891
Cdd:cd08728    161 NREIRQEFEDYLVQEMENY 179
RGS super family cl02565
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 938-1047 3.19e-08

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


The actual alignment was detected with superfamily member cd08725:

Pssm-ID: 470619  Cd Length: 123  Bit Score: 53.16  E-value: 3.19e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674137  938 NFAVNDIYFFSEMEKFNDLVTSahmlqvnkaynENDIVLMRSKLNIILKLYLISDLPPKLRVNISESQKDIIFSAITEgh 1017
Cdd:cd08725     19 EELENDLLFWLEVQKYKDLCHS-----------HSDEHIIQNKITAIISCFIDSSVPPALQIDIPPEIANRILEHRRE-- 85

                           90       100       110
                   ....*....|....*....|....*....|
gi 1958674137 1018 LDRTIFHGAIMSVFPVVMYFWKRFCSWKAT 1047
Cdd:cd08725     86 LGPYIFREAQLTVFRVLFKYWAGFCEFRKN 115
 
Name Accession Description Interval E-value
RGS-like_2 cd08728
Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These ...
 713-891 1.11e-87

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These uncharacterized RGS-like domains consists largely of hypothetical proteins. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play an important role in neuronal signal modulation. Some RGS proteins are the principal elements needed for proper vision.


Pssm-ID: 188683  Cd Length: 179  Bit Score: 280.57  E-value: 1.11e-87
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674137  713 LLNNAHLEYFREFLKDRKSENPLQFLIAVQKIMMETNEKTYKTSLENITKTYLHGKVPPEEILQCDAPFVKEVVNTRHIT 792
Cdd:cd08728      1 LRNHTHLEYFKRFLKSRGSDGPLLFWIAVEKMRVEENEKEQKAKIELIVKRYFHGQDPPGVLLQCEAIIIREIAMMKVVT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674137  793 TTTLLMLQGIIMKSVEEKWFKEYQDLFPPRPVEVEPVETHVVPRKPSKTITTHLHDSQKRGWIKMISFIKSFCKYRRFVT 872
Cdd:cd08728     81 TSMLLSIQHLVSKSLEERWFKKYQDTFPDCPHEVEPDEEIKVPLKPTKLKAPHVISSQKRAWEIFISFIRSFIKFRRFMV 160

                          170
                   ....*....|....*....
gi 1958674137  873 NAKNLQELTDFIYLEMYNN 891
Cdd:cd08728    161 NREIRQEFEDYLVQEMENY 179
RGS_RGS22_4 cd08725
Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) ...
 938-1047 3.19e-08

Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188680  Cd Length: 123  Bit Score: 53.16  E-value: 3.19e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674137  938 NFAVNDIYFFSEMEKFNDLVTSahmlqvnkaynENDIVLMRSKLNIILKLYLISDLPPKLRVNISESQKDIIFSAITEgh 1017
Cdd:cd08725     19 EELENDLLFWLEVQKYKDLCHS-----------HSDEHIIQNKITAIISCFIDSSVPPALQIDIPPEIANRILEHRRE-- 85

                           90       100       110
                   ....*....|....*....|....*....|
gi 1958674137 1018 LDRTIFHGAIMSVFPVVMYFWKRFCSWKAT 1047
Cdd:cd08725     86 LGPYIFREAQLTVFRVLFKYWAGFCEFRKN 115
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 708-817 2.05e-04

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 42.22  E-value: 2.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674137  708 NMTEILLNNAHLEYFREFLKDRKSENPLQFLIAVQ--KIMMETNEKTYKTslENITKTYLHGKVPPEeiLQCDAPFVKEV 785
Cdd:pfam00615    1 SFDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEefKKADPDEERLKKA--KEIYNEFLAPGSPKE--INLDSDLREEI 76

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1958674137  786 VN--TRHITTTTLLMLQGIIMKSVEEKWFKEYQD 817
Cdd:pfam00615   77 REnlEKEPTRDLFDEAQAEVYELMEKDSYPRFLK 110
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 710-772 3.46e-04

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 41.49  E-value: 3.46e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958674137   710 TEILLNNAHLEYFREFLKDRKSENPLQFLIAVQKI-MMETNEKTYKTSLEnITKTYLHGKVPPE 772
Cdd:smart00315    3 ESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFkKAEDDEERIAKARE-IYDKFLSPNAPKE 65
 
Name Accession Description Interval E-value
RGS-like_2 cd08728
Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These ...
 713-891 1.11e-87

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These uncharacterized RGS-like domains consists largely of hypothetical proteins. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play an important role in neuronal signal modulation. Some RGS proteins are the principal elements needed for proper vision.


Pssm-ID: 188683  Cd Length: 179  Bit Score: 280.57  E-value: 1.11e-87
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674137  713 LLNNAHLEYFREFLKDRKSENPLQFLIAVQKIMMETNEKTYKTSLENITKTYLHGKVPPEEILQCDAPFVKEVVNTRHIT 792
Cdd:cd08728      1 LRNHTHLEYFKRFLKSRGSDGPLLFWIAVEKMRVEENEKEQKAKIELIVKRYFHGQDPPGVLLQCEAIIIREIAMMKVVT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674137  793 TTTLLMLQGIIMKSVEEKWFKEYQDLFPPRPVEVEPVETHVVPRKPSKTITTHLHDSQKRGWIKMISFIKSFCKYRRFVT 872
Cdd:cd08728     81 TSMLLSIQHLVSKSLEERWFKKYQDTFPDCPHEVEPDEEIKVPLKPTKLKAPHVISSQKRAWEIFISFIRSFIKFRRFMV 160

                          170
                   ....*....|....*....
gi 1958674137  873 NAKNLQELTDFIYLEMYNN 891
Cdd:cd08728    161 NREIRQEFEDYLVQEMENY 179
RGS cd07440
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 713-815 2.03e-11

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


Pssm-ID: 188659 [Multi-domain]  Cd Length: 113  Bit Score: 62.02  E-value: 2.03e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674137  713 LLNNAHLEYFREFLKDRKSENPLQFLIAVQKIMMETNEKTYKTSL-ENITKTYLHGKVP-----PEEILQCdapfVKEVV 786
Cdd:cd07440      1 LRDPYGLEYFRQFLKSEHCEENLEFWLAVEKFKKTTSSDEELKSKaKEIYDKYISKDAPkeiniPESIREE----IEENL 76

                           90       100
                   ....*....|....*....|....*....
gi 1958674137  787 NTRHITTTTLLMLQGIIMKSVEEKWFKEY 815
Cdd:cd07440     77 EEPYPDPDCFDEAQEHILNLLEKDSYPRF 105
RGS_RGS22_4 cd08725
Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) ...
 938-1047 3.19e-08

Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188680  Cd Length: 123  Bit Score: 53.16  E-value: 3.19e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674137  938 NFAVNDIYFFSEMEKFNDLVTSahmlqvnkaynENDIVLMRSKLNIILKLYLISDLPPKLRVNISESQKDIIFSAITEgh 1017
Cdd:cd08725     19 EELENDLLFWLEVQKYKDLCHS-----------HSDEHIIQNKITAIISCFIDSSVPPALQIDIPPEIANRILEHRRE-- 85

                           90       100       110
                   ....*....|....*....|....*....|
gi 1958674137 1018 LDRTIFHGAIMSVFPVVMYFWKRFCSWKAT 1047
Cdd:cd08725     86 LGPYIFREAQLTVFRVLFKYWAGFCEFRKN 115
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 708-817 2.05e-04

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 42.22  E-value: 2.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958674137  708 NMTEILLNNAHLEYFREFLKDRKSENPLQFLIAVQ--KIMMETNEKTYKTslENITKTYLHGKVPPEeiLQCDAPFVKEV 785
Cdd:pfam00615    1 SFDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEefKKADPDEERLKKA--KEIYNEFLAPGSPKE--INLDSDLREEI 76

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1958674137  786 VN--TRHITTTTLLMLQGIIMKSVEEKWFKEYQD 817
Cdd:pfam00615   77 REnlEKEPTRDLFDEAQAEVYELMEKDSYPRFLK 110
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 710-772 3.46e-04

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 41.49  E-value: 3.46e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958674137   710 TEILLNNAHLEYFREFLKDRKSENPLQFLIAVQKI-MMETNEKTYKTSLEnITKTYLHGKVPPE 772
Cdd:smart00315    3 ESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFkKAEDDEERIAKARE-IYDKFLSPNAPKE 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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