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Conserved domains on  [gi|1958649789|ref|XP_038947273|]
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tumor protein D53 isoform X4 [Rattus norvegicus]

Protein Classification

D52 family tumor protein( domain architecture ID 10514819)

D52 family tumor protein similar to Homo sapiens tumor protein D52 (TPD52) that may play roles in calcium-mediated signal transduction and cell proliferation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPD52 pfam04201
Tumour protein D52 family; The hD52 gene was originally identified through its elevated ...
 31-156 1.05e-52

Tumour protein D52 family; The hD52 gene was originally identified through its elevated expression level in human breast carcinoma. Cloning of D52 homologs from other species has indicated that D52 may play roles in calcium-mediated signal transduction and cell proliferation. Two human homologs of hD52, hD53 and hD54, have also been identified, demonstrating the existence of a novel gene/protein family. These proteins have an amino terminal coiled-coil that allows members to form homo- and heterodimers with each other.


:

Pssm-ID: 461225  Cd Length: 99  Bit Score: 163.01  E-value: 1.05e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649789  31 LSEEEKDELKAELVQLEEEITTLRQVLSAKERHLVEIKQKLGMNLMNELKQNFSRSWHDMQTTTAYKKthetlshagQKA 110
Cdd:pfam04201   1 LTEAEQEELKSELTKLEEEIVTLRQVLAAKEKHCAELKRKLGLTPLVELKQNLSKSWHDVQVSNAYKK---------QKT 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1958649789 111 TAAFSNVGTAISRKFGDmrshsigysirhsismpaMRNSPTFKSFE 156
Cdd:pfam04201  72 SAALSTVGSAICRKLGD------------------MRNSPTFKSFE 99
 
Name Accession Description Interval E-value
TPD52 pfam04201
Tumour protein D52 family; The hD52 gene was originally identified through its elevated ...
 31-156 1.05e-52

Tumour protein D52 family; The hD52 gene was originally identified through its elevated expression level in human breast carcinoma. Cloning of D52 homologs from other species has indicated that D52 may play roles in calcium-mediated signal transduction and cell proliferation. Two human homologs of hD52, hD53 and hD54, have also been identified, demonstrating the existence of a novel gene/protein family. These proteins have an amino terminal coiled-coil that allows members to form homo- and heterodimers with each other.


Pssm-ID: 461225  Cd Length: 99  Bit Score: 163.01  E-value: 1.05e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649789  31 LSEEEKDELKAELVQLEEEITTLRQVLSAKERHLVEIKQKLGMNLMNELKQNFSRSWHDMQTTTAYKKthetlshagQKA 110
Cdd:pfam04201   1 LTEAEQEELKSELTKLEEEIVTLRQVLAAKEKHCAELKRKLGLTPLVELKQNLSKSWHDVQVSNAYKK---------QKT 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1958649789 111 TAAFSNVGTAISRKFGDmrshsigysirhsismpaMRNSPTFKSFE 156
Cdd:pfam04201  72 SAALSTVGSAICRKLGD------------------MRNSPTFKSFE 99
 
Name Accession Description Interval E-value
TPD52 pfam04201
Tumour protein D52 family; The hD52 gene was originally identified through its elevated ...
 31-156 1.05e-52

Tumour protein D52 family; The hD52 gene was originally identified through its elevated expression level in human breast carcinoma. Cloning of D52 homologs from other species has indicated that D52 may play roles in calcium-mediated signal transduction and cell proliferation. Two human homologs of hD52, hD53 and hD54, have also been identified, demonstrating the existence of a novel gene/protein family. These proteins have an amino terminal coiled-coil that allows members to form homo- and heterodimers with each other.


Pssm-ID: 461225  Cd Length: 99  Bit Score: 163.01  E-value: 1.05e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649789  31 LSEEEKDELKAELVQLEEEITTLRQVLSAKERHLVEIKQKLGMNLMNELKQNFSRSWHDMQTTTAYKKthetlshagQKA 110
Cdd:pfam04201   1 LTEAEQEELKSELTKLEEEIVTLRQVLAAKEKHCAELKRKLGLTPLVELKQNLSKSWHDVQVSNAYKK---------QKT 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1958649789 111 TAAFSNVGTAISRKFGDmrshsigysirhsismpaMRNSPTFKSFE 156
Cdd:pfam04201  72 SAALSTVGSAICRKLGD------------------MRNSPTFKSFE 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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