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Conserved domains on  [gi|1958673411|ref|XP_038947056|]
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flavin-containing monooxygenase 3 isoform X1 [Rattus norvegicus]

Protein Classification

flavin-binding monooxygenase-like family protein( domain architecture ID 1000557)

flavin-binding monooxygenase-like family protein; such as flavin-containing monooxygenases (FMOs) that catalyze the monooxygenation of a variety of substrates

EC:  1.14.13.-
Gene Ontology:  GO:0004497

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
FMO-like super family cl30939
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 2-530 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


The actual alignment was detected with superfamily member pfam00743:

Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 951.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411   2 KRKVAVIGAGVSGLAAIRSCLEEGLEPTCFERSDDVGGLWKFSDHTEEGRASIYQSVFTNSSKEMMCFPDFPYPDDFPNF 81
Cdd:pfam00743   1 AKKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEGRASIYKSVITNTSKEMSCFSDFPFPEDYPNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411  82 MHNSKLQEYITSFATEKNLLKYIQFETLVTRINKCPDFSTTGKWEVTTEKNSKKETAVFDAVMICSGHHVYPHLPKDSFP 161
Cdd:pfam00743  81 MHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPLESFP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 162 GLNRFKGKCFHSRDYKEPGTWKGKRVLVIGLGNSGCDIAAELSHVAQQVIISSRSGSWVMSRVWNDGYPWDMVVITRFQT 241
Cdd:pfam00743 161 GIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLFSTRFTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 242 FLKNNLPTAISDWWYMKQMNARFKHENYGLMPLNGTLRKEPVFNDELPARILCGTVSIKPNVKEFTETSAVFEDGTVFEG 321
Cdd:pfam00743 241 FLRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKEPVVNDDLPNRILCGAVKVKPNVKEFTETSAIFEDGTVEED 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 322 IDCVIFATGYGYAYPFLDDSIIKSRNNEVTLYKGIFPPQLEKPTMAVIGLVQSLGAAIPTTDLQARWAAQVIRGTCILPS 401
Cdd:pfam00743 321 IDVVIFATGYTFAFPFLEESLVKVENNKVSLYKYVFPPNLEKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLCTLPS 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 402 VNDMMDDIDEKMGKKLKWFGNS--TTIQTDYIVYMDELASFIGAKPNILWLFLKDPRLAIEVFFGPCSPYQFRLVGPGKW 479
Cdd:pfam00743 401 QSEMMAEINKRQEKKIKRFGDSqsHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVGPGKW 480

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958673411 480 SGARNAILTQWDRSLKPMKTRDVGGIQKPCLYSHFLRLLAVPVLIALFLVL 530
Cdd:pfam00743 481 EGARNAILTQWDRILKPLKTRVVEKSSSPASSFTLKIFGLPVVLVAIFLIL 531
 
Name Accession Description Interval E-value
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 2-530 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 951.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411   2 KRKVAVIGAGVSGLAAIRSCLEEGLEPTCFERSDDVGGLWKFSDHTEEGRASIYQSVFTNSSKEMMCFPDFPYPDDFPNF 81
Cdd:pfam00743   1 AKKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEGRASIYKSVITNTSKEMSCFSDFPFPEDYPNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411  82 MHNSKLQEYITSFATEKNLLKYIQFETLVTRINKCPDFSTTGKWEVTTEKNSKKETAVFDAVMICSGHHVYPHLPKDSFP 161
Cdd:pfam00743  81 MHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPLESFP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 162 GLNRFKGKCFHSRDYKEPGTWKGKRVLVIGLGNSGCDIAAELSHVAQQVIISSRSGSWVMSRVWNDGYPWDMVVITRFQT 241
Cdd:pfam00743 161 GIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLFSTRFTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 242 FLKNNLPTAISDWWYMKQMNARFKHENYGLMPLNGTLRKEPVFNDELPARILCGTVSIKPNVKEFTETSAVFEDGTVFEG 321
Cdd:pfam00743 241 FLRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKEPVVNDDLPNRILCGAVKVKPNVKEFTETSAIFEDGTVEED 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 322 IDCVIFATGYGYAYPFLDDSIIKSRNNEVTLYKGIFPPQLEKPTMAVIGLVQSLGAAIPTTDLQARWAAQVIRGTCILPS 401
Cdd:pfam00743 321 IDVVIFATGYTFAFPFLEESLVKVENNKVSLYKYVFPPNLEKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLCTLPS 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 402 VNDMMDDIDEKMGKKLKWFGNS--TTIQTDYIVYMDELASFIGAKPNILWLFLKDPRLAIEVFFGPCSPYQFRLVGPGKW 479
Cdd:pfam00743 401 QSEMMAEINKRQEKKIKRFGDSqsHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVGPGKW 480

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958673411 480 SGARNAILTQWDRSLKPMKTRDVGGIQKPCLYSHFLRLLAVPVLIALFLVL 530
Cdd:pfam00743 481 EGARNAILTQWDRILKPLKTRVVEKSSSPASSFTLKIFGLPVVLVAIFLIL 531
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 5-394 4.36e-88

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 277.13  E-value: 4.36e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411   5 VAVIGAGVSGLAAIRSCLEEGLEPTCFERSDDVGGLWkfsdhteegRASIYQSVFTNSSKEMMCFPDFPYPDDFPNFMHN 84
Cdd:COG2072     9 VVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTW---------RDNRYPGLRLDTPSHLYSLPFFPNWSDDPDFPTG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411  85 SKLQEYITSFATEKNLLKYIQFETLVTRINKCPDfstTGKWEVTTeknSKKETAVFDAVMICSGHHVYPHLPkdSFPGLN 164
Cdd:COG2072    80 DEILAYLEAYADKFGLRRPIRFGTEVTSARWDEA---DGRWTVTT---DDGETLTARFVVVATGPLSRPKIP--DIPGLE 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 165 RFKGKCFHSRDYKEPGTWKGKRVLVIGLGNSGCDIAAELSHVAQQVIISSRSGSWVMSRvwnDGYPWDMvviTRFQTFLK 244
Cdd:COG2072   152 DFAGEQLHSADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPR---PNYDPER---GRPANYLG 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 245 NNLPTAISD----WWYMKQMNARFKHENYG-LMPLNGTLRKEPVFNDELPARILCGTVSIK-PNVKEFTETSAVFEDGTV 318
Cdd:COG2072   226 LEAPPALNRrdarAWLRRLLRAQVKDPELGlLTPDYPPGCKRPLLSTDYYEALRRGNVELVtGGIERITEDGVVFADGTE 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 319 FEgIDCVIFATGYGYAYPFLDDSIIKSRN--NEVTLYKGIFPPQLekPTMAVIGLVQSLGAA--IPTTDLQARWAAQVIR 394
Cdd:COG2072   306 HE-VDVIVWATGFRADLPWLAPLDVRGRDgrSGPRAYLGVVVPGF--PNLFFLGPNSPSGHSslTLGAERQARYIARLIA 382
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 5-449 5.53e-54

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 188.92  E-value: 5.53e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411   5 VAVIGAGVSGLAAIRSCLEEGLEPTCFERSDDVGGLWKFSDHTEEG-----------RASIYQSVFTNSSKEMMCFPDFP 73
Cdd:PLN02172   13 VAVIGAGAAGLVAARELRREGHTVVVFEREKQVGGLWVYTPKSESDplsldptrsivHSSVYESLRTNLPRECMGYRDFP 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411  74 Y---PDD-------FPNFMhnsKLQEYITSFATEKNLLKYIQFETLVTRINkcpdfSTTGKWEVTTEKN---SKKEtaVF 140
Cdd:PLN02172   93 FvprFDDesrdsrrYPSHR---EVLAYLQDFAREFKIEEMVRFETEVVRVE-----PVDGKWRVQSKNSggfSKDE--IF 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 141 DAVMICSGHHVYPHLPKdsFPGLNRFKGKCFHSRDYKEPGTWKGKRVLVIGLGNSGCDIAAELSHVAQQVIISSRSgswv 220
Cdd:PLN02172  163 DAVVVCNGHYTEPNVAH--IPGIKSWPGKQIHSHNYRVPDPFKNEVVVVIGNFASGADISRDIAKVAKEVHIASRA---- 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 221 msrvwndgypwdmvviTRFQTFLKnnLPTAISDWWYMKQMNarFKHENyglmplngtlrkepvfndelparilcGTVsik 300
Cdd:PLN02172  237 ----------------SESDTYEK--LPVPQNNLWMHSEID--TAHED--------------------------GSI--- 267

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 301 pnvkeftetsaVFEDGTVFEGiDCVIFATGYGYAYPFLD-DSIIKSRNNEVT-LYKGIFPPQLeKPTMAVIGLvQSLGAA 378
Cdd:PLN02172  268 -----------VFKNGKVVYA-DTIVHCTGYKYHFPFLEtNGYMRIDENRVEpLYKHVFPPAL-APGLSFIGL-PAMGIQ 333

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958673411 379 IPTTDLQARWAAQVIRGTCILPSVNDMMDDID------EKMGKKLKWFGNSTTIQTDyivYMDELASFIGAKPNILW 449
Cdd:PLN02172  334 FVMFEIQSKWVAAVLSGRVTLPSEDKMMEDINawyaslEALGIPKRYTHKLGKIQSE---YLNWIAEECGCPLVEHW 407
DNA_polB_alpha_exo cd05776
inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase alpha, a family-B DNA ...
 69-148 3.17e-03

inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase alpha, a family-B DNA polymerase; The 3'-5' exonuclease domain of eukaryotic DNA polymerase alpha. DNA polymerase alpha is a family-B DNA polymerase with a catalytic subunit that contains a DnaQ-like 3'-5' exonuclease domain. It is one of the three DNA-dependent type B DNA polymerases (delta and epsilon are the other two) that have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase alpha is almost exclusively required for the initiation of DNA replication and the priming of Okazaki fragments during elongation. It associates with DNA primase and is the only enzyme able to start DNA synthesis de novo. The catalytic subunit contains both polymerase and 3'-5' exonuclease domains, but only exhibits polymerase activity. The 3'-5' exonuclease domain contains three sequence motifs termed ExoI, ExoII and ExoIII, without the four conserved acidic residues that are crucial for metal binding and catalysis. This explains why in most organisms, that no specific repair role, other than check point control, has been assigned to this enzyme. The exonuclease domain may have a structural role.


Pssm-ID: 99819 [Multi-domain]  Cd Length: 234  Bit Score: 39.13  E-value: 3.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411  69 FPDFPYPDDFPNFMHNSKLQEYITSFATEKNLLKY--------------------IQFETLVTRINKC--PDFSTTGKWE 126
Cdd:cd05776    54 RPLGRSPPPDLFEKNAKKKKTKVRIFENERALLNFflaklqkidpdvlvghdlegFDLDVLLSRIQELkvPHWSRIGRLK 133

                          90       100
                  ....*....|....*....|..
gi 1958673411 127 VtTEKNSKKETAVFDAVMICSG 148
Cdd:cd05776   134 R-SVWPKKKGGGKFGERELTAG 154
 
Name Accession Description Interval E-value
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 2-530 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 951.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411   2 KRKVAVIGAGVSGLAAIRSCLEEGLEPTCFERSDDVGGLWKFSDHTEEGRASIYQSVFTNSSKEMMCFPDFPYPDDFPNF 81
Cdd:pfam00743   1 AKKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEGRASIYKSVITNTSKEMSCFSDFPFPEDYPNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411  82 MHNSKLQEYITSFATEKNLLKYIQFETLVTRINKCPDFSTTGKWEVTTEKNSKKETAVFDAVMICSGHHVYPHLPKDSFP 161
Cdd:pfam00743  81 MHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPLESFP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 162 GLNRFKGKCFHSRDYKEPGTWKGKRVLVIGLGNSGCDIAAELSHVAQQVIISSRSGSWVMSRVWNDGYPWDMVVITRFQT 241
Cdd:pfam00743 161 GIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLFSTRFTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 242 FLKNNLPTAISDWWYMKQMNARFKHENYGLMPLNGTLRKEPVFNDELPARILCGTVSIKPNVKEFTETSAVFEDGTVFEG 321
Cdd:pfam00743 241 FLRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKEPVVNDDLPNRILCGAVKVKPNVKEFTETSAIFEDGTVEED 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 322 IDCVIFATGYGYAYPFLDDSIIKSRNNEVTLYKGIFPPQLEKPTMAVIGLVQSLGAAIPTTDLQARWAAQVIRGTCILPS 401
Cdd:pfam00743 321 IDVVIFATGYTFAFPFLEESLVKVENNKVSLYKYVFPPNLEKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLCTLPS 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 402 VNDMMDDIDEKMGKKLKWFGNS--TTIQTDYIVYMDELASFIGAKPNILWLFLKDPRLAIEVFFGPCSPYQFRLVGPGKW 479
Cdd:pfam00743 401 QSEMMAEINKRQEKKIKRFGDSqsHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVGPGKW 480

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958673411 480 SGARNAILTQWDRSLKPMKTRDVGGIQKPCLYSHFLRLLAVPVLIALFLVL 530
Cdd:pfam00743 481 EGARNAILTQWDRILKPLKTRVVEKSSSPASSFTLKIFGLPVVLVAIFLIL 531
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 5-394 4.36e-88

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 277.13  E-value: 4.36e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411   5 VAVIGAGVSGLAAIRSCLEEGLEPTCFERSDDVGGLWkfsdhteegRASIYQSVFTNSSKEMMCFPDFPYPDDFPNFMHN 84
Cdd:COG2072     9 VVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTW---------RDNRYPGLRLDTPSHLYSLPFFPNWSDDPDFPTG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411  85 SKLQEYITSFATEKNLLKYIQFETLVTRINKCPDfstTGKWEVTTeknSKKETAVFDAVMICSGHHVYPHLPkdSFPGLN 164
Cdd:COG2072    80 DEILAYLEAYADKFGLRRPIRFGTEVTSARWDEA---DGRWTVTT---DDGETLTARFVVVATGPLSRPKIP--DIPGLE 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 165 RFKGKCFHSRDYKEPGTWKGKRVLVIGLGNSGCDIAAELSHVAQQVIISSRSGSWVMSRvwnDGYPWDMvviTRFQTFLK 244
Cdd:COG2072   152 DFAGEQLHSADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPR---PNYDPER---GRPANYLG 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 245 NNLPTAISD----WWYMKQMNARFKHENYG-LMPLNGTLRKEPVFNDELPARILCGTVSIK-PNVKEFTETSAVFEDGTV 318
Cdd:COG2072   226 LEAPPALNRrdarAWLRRLLRAQVKDPELGlLTPDYPPGCKRPLLSTDYYEALRRGNVELVtGGIERITEDGVVFADGTE 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 319 FEgIDCVIFATGYGYAYPFLDDSIIKSRN--NEVTLYKGIFPPQLekPTMAVIGLVQSLGAA--IPTTDLQARWAAQVIR 394
Cdd:COG2072   306 HE-VDVIVWATGFRADLPWLAPLDVRGRDgrSGPRAYLGVVVPGF--PNLFFLGPNSPSGHSslTLGAERQARYIARLIA 382
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 5-449 5.53e-54

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 188.92  E-value: 5.53e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411   5 VAVIGAGVSGLAAIRSCLEEGLEPTCFERSDDVGGLWKFSDHTEEG-----------RASIYQSVFTNSSKEMMCFPDFP 73
Cdd:PLN02172   13 VAVIGAGAAGLVAARELRREGHTVVVFEREKQVGGLWVYTPKSESDplsldptrsivHSSVYESLRTNLPRECMGYRDFP 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411  74 Y---PDD-------FPNFMhnsKLQEYITSFATEKNLLKYIQFETLVTRINkcpdfSTTGKWEVTTEKN---SKKEtaVF 140
Cdd:PLN02172   93 FvprFDDesrdsrrYPSHR---EVLAYLQDFAREFKIEEMVRFETEVVRVE-----PVDGKWRVQSKNSggfSKDE--IF 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 141 DAVMICSGHHVYPHLPKdsFPGLNRFKGKCFHSRDYKEPGTWKGKRVLVIGLGNSGCDIAAELSHVAQQVIISSRSgswv 220
Cdd:PLN02172  163 DAVVVCNGHYTEPNVAH--IPGIKSWPGKQIHSHNYRVPDPFKNEVVVVIGNFASGADISRDIAKVAKEVHIASRA---- 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 221 msrvwndgypwdmvviTRFQTFLKnnLPTAISDWWYMKQMNarFKHENyglmplngtlrkepvfndelparilcGTVsik 300
Cdd:PLN02172  237 ----------------SESDTYEK--LPVPQNNLWMHSEID--TAHED--------------------------GSI--- 267

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 301 pnvkeftetsaVFEDGTVFEGiDCVIFATGYGYAYPFLD-DSIIKSRNNEVT-LYKGIFPPQLeKPTMAVIGLvQSLGAA 378
Cdd:PLN02172  268 -----------VFKNGKVVYA-DTIVHCTGYKYHFPFLEtNGYMRIDENRVEpLYKHVFPPAL-APGLSFIGL-PAMGIQ 333

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958673411 379 IPTTDLQARWAAQVIRGTCILPSVNDMMDDID------EKMGKKLKWFGNSTTIQTDyivYMDELASFIGAKPNILW 449
Cdd:PLN02172  334 FVMFEIQSKWVAAVLSGRVTLPSEDKMMEDINawyaslEALGIPKRYTHKLGKIQSE---YLNWIAEECGCPLVEHW 407
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
75-357 6.32e-13

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 69.56  E-value: 6.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411  75 PDDFPNFMHNSKLQ--EYITSFATEKNLLkyIQFETLVTRINKcpdfsTTGKWEVTTEKnskketAVFDA--VMICSGHH 150
Cdd:pfam13738  63 PAFTFNREHPSGNEyaEYLRRVADHFELP--INLFEEVTSVKK-----EDDGFVVTTSK------GTYQAryVIIATGEF 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 151 VYPHLPkdsfpglnRFKGKCFHSRDYKEPGTWKGKRVLVIGLGNSGCDIAAELSHVAQQVIISSRSGSWvMSRVWNDGY- 229
Cdd:pfam13738 130 DFPNKL--------GVPELPKHYSYVKDFHPYAGQKVVVIGGYNSAVDAALELVRKGARVTVLYRGSEW-EDRDSDPSYs 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 230 --PWdmvVITRFQTFLKNnlptaisdwwymKQMNARFKHEnyglmplngtlrkepvfndelparilcgtvsikpnVKEFT 307
Cdd:pfam13738 201 lsPD---TLNRLEELVKN------------GKIKAHFNAE-----------------------------------VKEIT 230

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958673411 308 ETSAV----FEDGTVFEGIDCVIFATGYGYAYPFLDDSIIKSRNN---------EVTLYKGIF 357
Cdd:pfam13738 231 EVDVSykvhTEDGRKVTSNDDPILATGYHPDLSFLKKGLFELDEDgrpvlteetESTNVPGLF 293
YdhS COG4529
Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];
3-238 9.00e-09

Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];


Pssm-ID: 443597 [Multi-domain]  Cd Length: 466  Bit Score: 57.66  E-value: 9.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411   3 RKVAVIGAGVSGLAAIRSCLEEGLEP---TCFERSDDVGglwkfsdhteEGRAsiYQsvfTNS--------SKEMmcFPD 71
Cdd:COG4529     6 KRIAIIGGGASGTALAIHLLRRAPEPlriTLFEPRPELG----------RGVA--YS---TDSpehllnvpAGRM--SAF 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411  72 FPYPDDFPNFMHNSKLQ-----------------EYITSF-------ATEKNLLKYIQFEtlVTRInkcpdFSTTGKWEV 127
Cdd:COG4529    69 PDDPDHFLRWLRENGARaapaidpdafvprrlfgEYLRERlaealarAPAGVRLRHIRAE--VVDL-----ERDDGGYRV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 128 TTEKNskkETAVFDAVMICSGHHVyPHLPKDSFPGLNRFkgkcFHS--RDYKEPGTWKGKRVLVIGLGNSGCDIAAEL-- 203
Cdd:COG4529   142 TLADG---ETLRADAVVLATGHPP-PAPPPGLAAGSPRY----IADpwPPGALARIPPDARVLIIGTGLTAIDVVLSLaa 213

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1958673411 204 SHVAQQVIISSRSGswVMSRVWNDGYPWDMVVITR 238
Cdd:COG4529   214 RGHRGPITALSRRG--LLPRAHPPGAPLPLKFLTP 246
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
4-212 4.68e-08

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 54.74  E-value: 4.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411   4 KVAVIGAGVSGLAAIRSCLEEGLEPTCFERsDDVGG-LWKFSDhteegrasIYqsvftNsskemmcFPDFPYPDDFPNFM 82
Cdd:COG0492     2 DVVIIGAGPAGLTAAIYAARAGLKTLVIEG-GEPGGqLATTKE--------IE-----N-------YPGFPEGISGPELA 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411  83 HNskLQEYITSFATEknllkyIQFETlVTRINKcpdfsTTGKWEVTTEKNskkETAVFDAVMICSGhhVYPHLPKdsFPG 162
Cdd:COG0492    61 ER--LREQAERFGAE------ILLEE-VTSVDK-----DDGPFRVTTDDG---TEYEAKAVIIATG--AGPRKLG--LPG 119

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958673411 163 LNRFKGKCFHS------RDYKepgtwkGKRVLVIGLGNSGCDIAAELSHVAQQVII 212
Cdd:COG0492   120 EEEFEGRGVSYcatcdgFFFR------GKDVVVVGGGDSALEEALYLTKFASKVTL 169
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 2-40 1.33e-07

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 54.07  E-value: 1.33e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958673411   2 KRKVAVIGAGVSGLAAIRSCLEEGLEPTCFERSDDVGGL 40
Cdd:COG1232     1 MKRVAVIGGGIAGLTAAYRLAKAGHEVTVLEASDRVGGL 39
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 4-331 2.31e-07

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 52.71  E-value: 2.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411   4 KVAVIGAGVSGLAAIRSCLEEGLEPTCFErsddVGGLWKfsdhteeGRASIYQSVFTNSSKemmcfpDFPYPDDFPNFMH 83
Cdd:pfam07992   2 DVVVIGGGPAGLAAALTLAQLGGKVTLIE----DEGTCP-------YGGCVLSKALLGAAE------APEIASLWADLYK 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411  84 nsKLQEYITSFATE-KNLLKyiqfeTLVTRINKcpdfsTTGKWEVTTEKNSKKETAVFDAVMICSGHHvyPHLPkdSFPG 162
Cdd:pfam07992  65 --RKEEVVKKLNNGiEVLLG-----TEVVSIDP-----GAKKVVLEELVDGDGETITYDRLVIATGAR--PRLP--PIPG 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 163 LNrfKGKCFHSRDYKEPG----TWKGKRVLVIGLGNSGCDIAAELSHVAQQVIISSRSgswvmsrvwndgypwdmvvitr 238
Cdd:pfam07992 129 VE--LNVGFLVRTLDSAEalrlKLLPKRVVVVGGGYIGVELAAALAKLGKEVTLIEAL---------------------- 184

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411 239 fqTFLKNNLPTAISDWwymkqMNARFKHENyglmplngtlrkepVfndelpaRILCGTVsikpnVKEFTETS----AVFE 314
Cdd:pfam07992 185 --DRLLRAFDEEISAA-----LEKALEKNG--------------V-------EVRLGTS-----VKEIIGDGdgveVILK 231

                         330
                  ....*....|....*..
gi 1958673411 315 DGTVFEGiDCVIFATGY 331
Cdd:pfam07992 232 DGTEIDA-DLVVVAIGR 247
PRK07233 PRK07233
hypothetical protein; Provisional
 4-49 2.46e-06

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 49.89  E-value: 2.46e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1958673411   4 KVAVIGAGVSGLAAIRSCLEEGLEPTCFERSDDVGGL---WKFSDHTEE 49
Cdd:PRK07233    1 KIAIVGGGIAGLAAAYRLAKRGHEVTVFEADDQLGGLaasFEFGGLPIE 49
COG3380 COG3380
Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];
1-39 9.10e-06

Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];


Pssm-ID: 442607 [Multi-domain]  Cd Length: 331  Bit Score: 47.95  E-value: 9.10e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958673411   1 MKRKVAVIGAGVSGLAAIRSCLEEGLEPTCFERSDDVGG 39
Cdd:COG3380     2 SMPDIAIIGAGIAGLAAARALQDAGHEVTVFEKSRGVGG 40
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 3-200 1.26e-05

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 47.82  E-value: 1.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411   3 RKVAVIGAGVSGLAAIRSCLEEGLEPTCFERSDDVGGlwkfsdhteegrasiyqsvftnsskeMMCF--PDFPYPDDFpn 80
Cdd:COG0493   122 KKVAVVGSGPAGLAAAYQLARAGHEVTVFEALDKPGG--------------------------LLRYgiPEFRLPKDV-- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411  81 fmhnskLQEYItsfateKNLLKY-IQFETLvTRINKcpdfsttgkwEVTTEKNSKKetavFDAVMICSGHHVYPHLPkds 159
Cdd:COG0493   174 ------LDREI------ELIEALgVEFRTN-VEVGK----------DITLDELLEE----FDAVFLATGAGKPRDLG--- 223

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958673411 160 FPGlnRFKGKCFHSRDY-------KEPGTW--KGKRVLVIGLGNSGCDIA 200
Cdd:COG0493   224 IPG--EDLKGVHSAMDFltavnlgEAPDTIlaVGKRVVVIGGGNTAMDCA 271
PRK07208 PRK07208
hypothetical protein; Provisional
 1-40 4.77e-05

hypothetical protein; Provisional


Pssm-ID: 235967 [Multi-domain]  Cd Length: 479  Bit Score: 46.04  E-value: 4.77e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1958673411   1 MKRKVAVIGAGVSGLAAIRSCLEEGLEPTCFERSDDVGGL 40
Cdd:PRK07208    3 NKKSVVIIGAGPAGLTAAYELLKRGYPVTVLEADPVVGGI 42
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
7-67 4.83e-05

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 41.36  E-value: 4.83e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958673411   7 VIGAGVSGLAAIRSCLEEGLEPTCFERSDDVGGL---WKFSDHTEEGRASIYQSVFTNSSKEMM 67
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRLGGNaysYRVPGYVFDYGAHIFHGSDEPNVRDLL 64
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
2-39 4.85e-05

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 45.68  E-value: 4.85e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958673411   2 KRKVAVIGAGVSGLAAIRSCLEEGLEPTCFERSDDVGG 39
Cdd:COG1231     7 GKDVVIVGAGLAGLAAARELRKAGLDVTVLEARDRVGG 44
NAD_binding_9 pfam13454
FAD-NAD(P)-binding;
6-149 5.70e-05

FAD-NAD(P)-binding;


Pssm-ID: 433222 [Multi-domain]  Cd Length: 155  Bit Score: 43.42  E-value: 5.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411   6 AVIGAGVSGLAA----IRSCLEEGLEPTCFERSDD-VGGLWkFSDHTEEGRasiyqsvfTNS-SKEMMCFPDfpYPDDFP 79
Cdd:pfam13454   1 AIVGGGPSGLALlerlLARAPKRPLEITLFDPSPPgAGGVY-RTDQSPEHL--------LNVpASRMSLFPD--DPPHFL 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411  80 NFMHNSKLQEYIT-----SFATEKNLLKYIQ--FETL----------------VTRINKCPDfsttgKWEVTTEKNskkE 136
Cdd:pfam13454  70 EWLRARGALDEAPgldpdDFPPRALYGRYLRdrFEEAlarapagvtvrvhrarVTDLRPRGD-----GYRVLLADG---R 141

                         170
                  ....*....|...
gi 1958673411 137 TAVFDAVMICSGH 149
Cdd:pfam13454 142 TLAADAVVLATGH 154
gltD PRK12810
glutamate synthase subunit beta; Reviewed
 3-40 8.45e-05

glutamate synthase subunit beta; Reviewed


Pssm-ID: 237213 [Multi-domain]  Cd Length: 471  Bit Score: 45.15  E-value: 8.45e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958673411   3 RKVAVIGAGVSGLAAIRSCLEEGLEPTCFERSDDVGGL 40
Cdd:PRK12810  144 KKVAVVGSGPAGLAAADQLARAGHKVTVFERADRIGGL 181
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 1-39 1.38e-04

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 44.46  E-value: 1.38e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958673411   1 MKRKVAVIGAGVSGLAAIRSCLEEGLEPTCFERSDDVGG 39
Cdd:COG3349     2 MPPRVVVVGGGLAGLAAAVELAEAGFRVTLLEARPRLGG 40
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 3-36 2.76e-04

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 43.53  E-value: 2.76e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1958673411   3 RKVAVIGAGVSGLAAIRSCLEEGLEPTCFERSDD 36
Cdd:COG0771     5 KKVLVLGLGKSGLAAARLLAKLGAEVTVSDDRPA 38
PRK11749 PRK11749
dihydropyrimidine dehydrogenase subunit A; Provisional
 2-40 2.10e-03

dihydropyrimidine dehydrogenase subunit A; Provisional


Pssm-ID: 236967 [Multi-domain]  Cd Length: 457  Bit Score: 40.55  E-value: 2.10e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958673411   2 KRKVAVIGAGVSGLAAIRSCLEEGLEPTCFERSDDVGGL 40
Cdd:PRK11749  140 GKKVAVIGAGPAGLTAAHRLARKGYDVTIFEARDKAGGL 178
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 1-39 2.14e-03

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 40.60  E-value: 2.14e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1958673411   1 MKRKVAVIGAGVSGL-AAIRscL-EEGLEPTCFERSDDVGG 39
Cdd:COG1233     2 MMYDVVVIGAGIGGLaAAAL--LaRAGYRVTVLEKNDTPGG 40
DNA_polB_alpha_exo cd05776
inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase alpha, a family-B DNA ...
 69-148 3.17e-03

inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase alpha, a family-B DNA polymerase; The 3'-5' exonuclease domain of eukaryotic DNA polymerase alpha. DNA polymerase alpha is a family-B DNA polymerase with a catalytic subunit that contains a DnaQ-like 3'-5' exonuclease domain. It is one of the three DNA-dependent type B DNA polymerases (delta and epsilon are the other two) that have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase alpha is almost exclusively required for the initiation of DNA replication and the priming of Okazaki fragments during elongation. It associates with DNA primase and is the only enzyme able to start DNA synthesis de novo. The catalytic subunit contains both polymerase and 3'-5' exonuclease domains, but only exhibits polymerase activity. The 3'-5' exonuclease domain contains three sequence motifs termed ExoI, ExoII and ExoIII, without the four conserved acidic residues that are crucial for metal binding and catalysis. This explains why in most organisms, that no specific repair role, other than check point control, has been assigned to this enzyme. The exonuclease domain may have a structural role.


Pssm-ID: 99819 [Multi-domain]  Cd Length: 234  Bit Score: 39.13  E-value: 3.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673411  69 FPDFPYPDDFPNFMHNSKLQEYITSFATEKNLLKY--------------------IQFETLVTRINKC--PDFSTTGKWE 126
Cdd:cd05776    54 RPLGRSPPPDLFEKNAKKKKTKVRIFENERALLNFflaklqkidpdvlvghdlegFDLDVLLSRIQELkvPHWSRIGRLK 133

                          90       100
                  ....*....|....*....|..
gi 1958673411 127 VtTEKNSKKETAVFDAVMICSG 148
Cdd:cd05776   134 R-SVWPKKKGGGKFGERELTAG 154
Ppro0129 COG2907
Predicted flavin-containing amine oxidase [General function prediction only];
1-47 5.94e-03

Predicted flavin-containing amine oxidase [General function prediction only];


Pssm-ID: 442151 [Multi-domain]  Cd Length: 423  Bit Score: 39.33  E-value: 5.94e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958673411   1 MKRKVAVIGAGVSGLAAIRsCLEEGLEPTCFERSDDVGGlwkfsdHT 47
Cdd:COG2907     2 ARMRIAVIGSGISGLTAAW-LLSRRHDVTLFEANDRLGG------HT 41
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 3-43 7.28e-03

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 38.96  E-value: 7.28e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1958673411   3 RKVAVIGAGVSGLAAIRSCLEEGLEPTCFERSDDVGGLWKF 43
Cdd:PRK12769  328 KRVAIIGAGPAGLACADVLARNGVAVTVYDRHPEIGGLLTF 368
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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