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Conserved domains on  [gi|1958673196|ref|XP_038946973|]
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kynurenine 3-monooxygenase isoform X3 [Rattus norvegicus]

Protein Classification

FAD-dependent oxidoreductase( domain architecture ID 11428987)

FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant

CATH:  3.50.50.60
EC:  1.-.-.-
Gene Ontology:  GO:0071949|GO:0016491

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 3-283 4.03e-16

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


:

Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 78.83  E-value: 4.03e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196   3 ARMIHSLSGKKSAIPYGnksqyiLSISREKLNKDLLTAVESYpNAKVHFGHKLSKCCPEEGILTML---GpnkvpRDITC 79
Cdd:COG0654    82 GRVLARFDAAETGLPAG------LVVPRADLERALLEAARAL-GVELRFGTEVTGLEQDADGVTVTladG-----RTLRA 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196  80 DLIVGCDGAYSTVRAHLMKKPR-FDYSQQYIphgymeltippkngeyamepnclhiWprnafmmialpnmdksftctlfm 158
Cdd:COG0654   150 DLVVGADGARSAVRRLLGIGFTgRDYPQRAL-------------------------W----------------------- 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196 159 sfeefeklpthSDVLDFFQKNFPDAIPLMGEqalMRDFFLLPAQPMISVKCSPFHlKSRCVLMGDAAHAIVPFFGQGMNA 238
Cdd:COG0654   182 -----------AGVRTELRARLAAAGPRLGE---LLELSPRSAFPLRRRRAERWR-RGRVVLLGDAAHTMHPLGGQGANL 246

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1958673196 239 GFEDCLVFDELMDKF--NNDLSVCLPEFSRFRIPDDHAISDLSMYNY 283
Cdd:COG0654   247 ALRDAAALAWKLAAAlrGRDDEAALARYERERRPRAARVQRAADALG 293
 
Name Accession Description Interval E-value
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 3-283 4.03e-16

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 78.83  E-value: 4.03e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196   3 ARMIHSLSGKKSAIPYGnksqyiLSISREKLNKDLLTAVESYpNAKVHFGHKLSKCCPEEGILTML---GpnkvpRDITC 79
Cdd:COG0654    82 GRVLARFDAAETGLPAG------LVVPRADLERALLEAARAL-GVELRFGTEVTGLEQDADGVTVTladG-----RTLRA 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196  80 DLIVGCDGAYSTVRAHLMKKPR-FDYSQQYIphgymeltippkngeyamepnclhiWprnafmmialpnmdksftctlfm 158
Cdd:COG0654   150 DLVVGADGARSAVRRLLGIGFTgRDYPQRAL-------------------------W----------------------- 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196 159 sfeefeklpthSDVLDFFQKNFPDAIPLMGEqalMRDFFLLPAQPMISVKCSPFHlKSRCVLMGDAAHAIVPFFGQGMNA 238
Cdd:COG0654   182 -----------AGVRTELRARLAAAGPRLGE---LLELSPRSAFPLRRRRAERWR-RGRVVLLGDAAHTMHPLGGQGANL 246

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1958673196 239 GFEDCLVFDELMDKF--NNDLSVCLPEFSRFRIPDDHAISDLSMYNY 283
Cdd:COG0654   247 ALRDAAALAWKLAAAlrGRDDEAALARYERERRPRAARVQRAADALG 293
Ubi-OHases TIGR01988
Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a ...
 33-275 7.54e-09

Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a family of FAD-dependent hydroxylases (monooxygenases) which are all believed to act in the aerobic ubiquinone biosynthesis pathway. A separate set of hydroxylases, as yet undiscovered, are believed to be active under anaerobic conditions. In E. coli three enzyme activities have been described, UbiB (which acts first at position 6, see TIGR01982), UbiH (which acts at position 4) and UbiF (which acts at position 5). UbiH and UbiF are similar to one another and form the basis of this subfamily. Interestingly, E. coli contains another hydroxylase gene, called visC, that is highly similar to UbiF, adjacent to UbiH and, when mutated, results in a phenotype similar to that of UbiH (which has also been named visB). Several other species appear to have three homologs in this family, although they assort themselves differently on phylogenetic trees (e.g. Xylella and Mesorhizobium) making it difficult to ascribe a specific activity to each one. Eukaryotes appear to have only a single homolog in this subfamily (COQ6) which complements UbiH, but also possess a non-orthologous gene, COQ7 which complements UbiF. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273913 [Multi-domain]  Cd Length: 385  Bit Score: 57.21  E-value: 7.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196  33 LNKDLLTAVESYPNAKVHFGHKLS--KCCPEEGILTmLGPNKVprdITCDLIVGCDGAYSTVRAHL-MKKPRFDYSQQYI 109
Cdd:TIGR01988 108 LQQALWERLQELPNVTLLCPARVVelPRHSDHVELT-LDDGQQ---LRARLLVGADGANSKVRQLAgIPTTGWDYGQSAV 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196 110 --------PHGY--MELTIPpkNGEYAM----EPNCLHIW---PRNAFMMIALPnmdksftctlfmsFEEFeklpthsdv 172
Cdd:TIGR01988 184 vanvkherPHQGtaWERFTP--TGPLALlplpDNRSSLVWtlpPEEAERLLALS-------------DEEF--------- 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196 173 LDFFQKNFPdaiPLMGEQALMRDFFLLPAQPMISVKcspfHLKSRCVLMGDAAHAIVPFFGQGMNAGFED------CLVF 246
Cdd:TIGR01988 240 LAELQRAFG---SRLGAITLVGERHAFPLSLTHAKR----YVAPRLALIGDAAHTIHPLAGQGLNLGLRDvaalaeVLED 312

                         250       260
                  ....*....|....*....|....*....
gi 1958673196 247 DELMDKFNNDLSVcLPEFSRFRIPDDHAI 275
Cdd:TIGR01988 313 ARRRGEDIGSLRV-LQRYERRRRFDNAAM 340
mhpA PRK06183
bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;
37-242 1.07e-08

bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;


Pssm-ID: 235727 [Multi-domain]  Cd Length: 500  Bit Score: 56.84  E-value: 1.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196  37 LLTAVESYPNAKVHFGHKLSKCCPEEG--ILTMLGPNKVPRDITCDLIVGCDGAYSTVRaHLMKKPRFDYSQqyiPHGYM 114
Cdd:PRK06183  119 LRAGLARFPHVRVRFGHEVTALTQDDDgvTVTLTDADGQRETVRARYVVGCDGANSFVR-RTLGVPFEDLTF---PERWL 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196 115 ELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFtctlfmsfeEFEKLP--THSDVLDffqknfPDAIplmgeQAL 192
Cdd:PRK06183  195 VVDVLIANDPLGGPHTYQYCDPARPYTSVRLPHGRRRW---------EFMLLPgeTEEQLAS------PENV-----WRL 254

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958673196 193 MRDFFLLPAQP-MISVKCSPFHL-------KSRCVLMGDAAHAIVPFFGQGMNAGFED 242
Cdd:PRK06183  255 LAPWGPTPDDAeLIRHAVYTFHArvadrwrSGRVLLAGDAAHLMPPFAGQGMNSGIRD 312
 
Name Accession Description Interval E-value
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 3-283 4.03e-16

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 78.83  E-value: 4.03e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196   3 ARMIHSLSGKKSAIPYGnksqyiLSISREKLNKDLLTAVESYpNAKVHFGHKLSKCCPEEGILTML---GpnkvpRDITC 79
Cdd:COG0654    82 GRVLARFDAAETGLPAG------LVVPRADLERALLEAARAL-GVELRFGTEVTGLEQDADGVTVTladG-----RTLRA 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196  80 DLIVGCDGAYSTVRAHLMKKPR-FDYSQQYIphgymeltippkngeyamepnclhiWprnafmmialpnmdksftctlfm 158
Cdd:COG0654   150 DLVVGADGARSAVRRLLGIGFTgRDYPQRAL-------------------------W----------------------- 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196 159 sfeefeklpthSDVLDFFQKNFPDAIPLMGEqalMRDFFLLPAQPMISVKCSPFHlKSRCVLMGDAAHAIVPFFGQGMNA 238
Cdd:COG0654   182 -----------AGVRTELRARLAAAGPRLGE---LLELSPRSAFPLRRRRAERWR-RGRVVLLGDAAHTMHPLGGQGANL 246

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1958673196 239 GFEDCLVFDELMDKF--NNDLSVCLPEFSRFRIPDDHAISDLSMYNY 283
Cdd:COG0654   247 ALRDAAALAWKLAAAlrGRDDEAALARYERERRPRAARVQRAADALG 293
FixC COG0644
Dehydrogenase (flavoprotein) [Energy production and conversion];
6-135 6.95e-09

Dehydrogenase (flavoprotein) [Energy production and conversion];


Pssm-ID: 440409 [Multi-domain]  Cd Length: 281  Bit Score: 56.51  E-value: 6.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196   6 IHSLSGKKSAIPYGNKSQYIlsISREKLNKDLLTAVESYpNAKVHFGHKLSKCCPEEGILTMLGPNkvPRDITCDLIVGC 85
Cdd:COG0644    63 FYSPGGKSVELPPGRGGGYV--VDRARFDRWLAEQAEEA-GAEVRTGTRVTDVLRDDGRVVVRTGD--GEEIRADYVVDA 137

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958673196  86 DGAYSTVRAHLMKKPRFDYSQQYIpHGYMELTIPPKNGEYamEPNCLHIW 135
Cdd:COG0644   138 DGARSLLARKLGLKRRSDEPQDYA-LAIKEHWELPPLEGV--DPGAVEFF 184
Ubi-OHases TIGR01988
Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a ...
 33-275 7.54e-09

Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a family of FAD-dependent hydroxylases (monooxygenases) which are all believed to act in the aerobic ubiquinone biosynthesis pathway. A separate set of hydroxylases, as yet undiscovered, are believed to be active under anaerobic conditions. In E. coli three enzyme activities have been described, UbiB (which acts first at position 6, see TIGR01982), UbiH (which acts at position 4) and UbiF (which acts at position 5). UbiH and UbiF are similar to one another and form the basis of this subfamily. Interestingly, E. coli contains another hydroxylase gene, called visC, that is highly similar to UbiF, adjacent to UbiH and, when mutated, results in a phenotype similar to that of UbiH (which has also been named visB). Several other species appear to have three homologs in this family, although they assort themselves differently on phylogenetic trees (e.g. Xylella and Mesorhizobium) making it difficult to ascribe a specific activity to each one. Eukaryotes appear to have only a single homolog in this subfamily (COQ6) which complements UbiH, but also possess a non-orthologous gene, COQ7 which complements UbiF. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273913 [Multi-domain]  Cd Length: 385  Bit Score: 57.21  E-value: 7.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196  33 LNKDLLTAVESYPNAKVHFGHKLS--KCCPEEGILTmLGPNKVprdITCDLIVGCDGAYSTVRAHL-MKKPRFDYSQQYI 109
Cdd:TIGR01988 108 LQQALWERLQELPNVTLLCPARVVelPRHSDHVELT-LDDGQQ---LRARLLVGADGANSKVRQLAgIPTTGWDYGQSAV 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196 110 --------PHGY--MELTIPpkNGEYAM----EPNCLHIW---PRNAFMMIALPnmdksftctlfmsFEEFeklpthsdv 172
Cdd:TIGR01988 184 vanvkherPHQGtaWERFTP--TGPLALlplpDNRSSLVWtlpPEEAERLLALS-------------DEEF--------- 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196 173 LDFFQKNFPdaiPLMGEQALMRDFFLLPAQPMISVKcspfHLKSRCVLMGDAAHAIVPFFGQGMNAGFED------CLVF 246
Cdd:TIGR01988 240 LAELQRAFG---SRLGAITLVGERHAFPLSLTHAKR----YVAPRLALIGDAAHTIHPLAGQGLNLGLRDvaalaeVLED 312

                         250       260
                  ....*....|....*....|....*....
gi 1958673196 247 DELMDKFNNDLSVcLPEFSRFRIPDDHAI 275
Cdd:TIGR01988 313 ARRRGEDIGSLRV-LQRYERRRRFDNAAM 340
mhpA PRK06183
bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;
37-242 1.07e-08

bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;


Pssm-ID: 235727 [Multi-domain]  Cd Length: 500  Bit Score: 56.84  E-value: 1.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196  37 LLTAVESYPNAKVHFGHKLSKCCPEEG--ILTMLGPNKVPRDITCDLIVGCDGAYSTVRaHLMKKPRFDYSQqyiPHGYM 114
Cdd:PRK06183  119 LRAGLARFPHVRVRFGHEVTALTQDDDgvTVTLTDADGQRETVRARYVVGCDGANSFVR-RTLGVPFEDLTF---PERWL 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196 115 ELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFtctlfmsfeEFEKLP--THSDVLDffqknfPDAIplmgeQAL 192
Cdd:PRK06183  195 VVDVLIANDPLGGPHTYQYCDPARPYTSVRLPHGRRRW---------EFMLLPgeTEEQLAS------PENV-----WRL 254

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958673196 193 MRDFFLLPAQP-MISVKCSPFHL-------KSRCVLMGDAAHAIVPFFGQGMNAGFED 242
Cdd:PRK06183  255 LAPWGPTPDDAeLIRHAVYTFHArvadrwrSGRVLLAGDAAHLMPPFAGQGMNSGIRD 312
PRK07364 PRK07364
FAD-dependent hydroxylase;
37-242 3.52e-08

FAD-dependent hydroxylase;


Pssm-ID: 236001 [Multi-domain]  Cd Length: 415  Bit Score: 55.03  E-value: 3.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196  37 LLTAVESYPNakvhfghkLSKCCPEEGILTMLGPNKV---------PRDITCDLIVGCDGAYSTVRAHLMKKPR-FDYSQ 106
Cdd:PRK07364  127 LQEFLQSCPN--------ITWLCPAEVVSVEYQQDAAtvtleiegkQQTLQSKLVVAADGARSPIRQAAGIKTKgWKYWQ 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196 107 QYI--------PHGYMeltippkngeyAMEpnclHIWPRNAFMMIALPNMDKSFTCTlfMSFEEFEKLPT--HSDVLDFF 176
Cdd:PRK07364  199 SCVtatvkheaPHNDI-----------AYE----RFWPSGPFAILPLPGNRCQIVWT--APHAQAKALLAlpEAEFLAEL 261

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958673196 177 QKNFPDaipLMGEQALMRDFFLLPAQPMISVKcspfHLKSRCVLMGDAAHAIVPFFGQGMNAGFED 242
Cdd:PRK07364  262 QQRYGD---QLGKLELLGDRFLFPVQLMQSDR----YVQHRLALVGDAAHCCHPVGGQGLNLGIRD 320
COQ6 TIGR01989
ubiquinone biosynthesis monooxygenase COQ6; This model represents the monooxygenase ...
 75-242 1.51e-07

ubiquinone biosynthesis monooxygenase COQ6; This model represents the monooxygenase responsible for the 4-hydroxylateion of the phenol ring in the aerobic biosynthesis of ubiquinone


Pssm-ID: 273914 [Multi-domain]  Cd Length: 437  Bit Score: 53.22  E-value: 1.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196  75 RDITCDLIVGCDGAYSTVR-AHLMKKPRFDYSQQYIPhGYMELTIPPKN----------GEYAMEP----NCLHIW---P 136
Cdd:TIGR01989 168 QVLYTKLLIGADGSNSNVRkAANIDTTGWNYNQHAVV-ATLKLEEATENdvawqrflptGPIALLPlpdnNSTLVWstsP 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196 137 RNAFMMIALPnmDKSFTCTLFMSFE-EFEKLPtHSDVLDFFQKNFPDAIPLMGEQAlMRDFFLLPAqpMISVKCS----- 210
Cdd:TIGR01989 247 EEALRLLSLP--PEDFVDALNAAFDlGYSDHP-YSYLLDYAMEKLNEDIGFRTEGS-KSCFQVPPR--VIGVVDKsraaf 320

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1958673196 211 PFHL-------KSRCVLMGDAAHAIVPFFGQGMNAGFED 242
Cdd:TIGR01989 321 PLGLghadeyvTKRVALVGDAAHRVHPLAGQGVNLGFGD 359
PRK06753 PRK06753
hypothetical protein; Provisional
 26-270 2.11e-07

hypothetical protein; Provisional


Pssm-ID: 168661 [Multi-domain]  Cd Length: 373  Bit Score: 52.77  E-value: 2.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196  26 LSISReklnKDLLTAVESY-PNAKVHFGHKLSKCCPEEGILTMLGPNKVPRDItcDLIVGCDGAYSTVRAHLMKKPRFDY 104
Cdd:PRK06753   93 VTLHR----QTLIDIIKSYvKEDAIFTGKEVTKIENETDKVTIHFADGESEAF--DLCIGADGIHSKVRQSVNADSKVRY 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196 105 SqqyiphGY-----MELTIPPKNGEYAMEpnclhIW-PRNAFMMIALPNMDKSFtctlFMSFEEFEKLPTHSDV----LD 174
Cdd:PRK06753  167 Q------GYtcfrgLIDDIDLKLPDCAKE-----YWgTKGRFGIVPLLNNQAYW----FITINAKERDPKYSSFgkphLQ 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196 175 FFQKNFPDAIPLMGEQA-----LMRDFFLLpaQPMISvkcspfHLKSRCVLMGDAAHAIVPFFGQGMNAGFEDCLVfdeL 249
Cdd:PRK06753  232 AYFNHYPNEVREILDKQsetgiLHHDIYDL--KPLKS------FVYGRIVLLGDAAHATTPNMGQGAGQAMEDAIV---L 300

                         250       260
                  ....*....|....*....|..
gi 1958673196 250 MDKFNN-DLSVCLPEFSRFRIP 270
Cdd:PRK06753  301 ANCLNAyDFEKALQRYDKIRVK 322
PRK08849 PRK08849
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional
 215-272 2.28e-07

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional


Pssm-ID: 181564 [Multi-domain]  Cd Length: 384  Bit Score: 52.47  E-value: 2.28e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958673196 215 KSRCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKfNNDLSVCLPE-FSRFRIPDD 272
Cdd:PRK08849  278 KNNCVLLGDAAHTINPLAGQGVNLGFKDVDVLLAETEK-QGVLNDASFArYERRRRPDN 335
PRK06126 PRK06126
hypothetical protein; Provisional
 37-242 8.65e-07

hypothetical protein; Provisional


Pssm-ID: 235704 [Multi-domain]  Cd Length: 545  Bit Score: 51.15  E-value: 8.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196  37 LLTAVESYPNAKVHFGHKLSKCCP-EEGILTM---LGPNKvPRDITCDLIVGCDGAYSTVRAHL---------------- 96
Cdd:PRK06126  132 LLEHAAAQPGVTLRYGHRLTDFEQdADGVTATvedLDGGE-SLTIRADYLVGCDGARSAVRRSLgisyegtsglqrdlsi 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196  97 -MKKPRFdysQQYIPH--GYMELTI-PPKNGEYAmepnclHIWPRNAFMMIALPnmdksftctlfmsFEEFEKLPTHSDV 172
Cdd:PRK06126  211 yIRAPGL---AALVGHdpAWMYWLFnPDRRGVLV------AIDGRDEWLFHQLR-------------GGEDEFTIDDVDA 268

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958673196 173 LDFFQKnfpdaipLMGEQAlmrDFFLLPAQPMISVK-CSPFHLKSRCVLMGDAAHAIVPFFGQGMNAGFED 242
Cdd:PRK06126  269 RAFVRR-------GVGEDI---DYEVLSVVPWTGRRlVADSYRRGRVFLAGDAAHLFTPTGGYGMNTGIGD 329
PRK06185 PRK06185
FAD-dependent oxidoreductase;
37-237 4.45e-06

FAD-dependent oxidoreductase;


Pssm-ID: 235729 [Multi-domain]  Cd Length: 407  Bit Score: 48.70  E-value: 4.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196  37 LLTAVESYPNAKVHFGHKLSKCCPEEGI---LTMLGPNKvPRDITCDLIVGCDGAYSTVR--AHLmkKPR-----FDYSq 106
Cdd:PRK06185  114 LAEEASAYPNFTLRMGAEVTGLIEEGGRvtgVRARTPDG-PGEIRADLVVGADGRHSRVRalAGL--EVRefgapMDVL- 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196 107 qyiphgYMELTIPPKNGEYAMEpnclHIWPRNafMMIALPNMDKsFTCTLFMSFEEFEKLptHSDVLDFFQKNFPDAIPL 186
Cdd:PRK06185  190 ------WFRLPREPDDPESLMG----RFGPGQ--GLIMIDRGDY-WQCGYVIPKGGYAAL--RAAGLEAFRERVAELAPE 254

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958673196 187 MGEQAL----MRDFFLLpaqpmiSVKCSpfHLK--SR--CVLMGDAAHAIVPFFGQGMN 237
Cdd:PRK06185  255 LADRVAelksWDDVKLL------DVRVD--RLRrwHRpgLLCIGDAAHAMSPVGGVGIN 305
PRK08850 PRK08850
2-octaprenyl-6-methoxyphenol hydroxylase; Validated
 75-242 3.35e-05

2-octaprenyl-6-methoxyphenol hydroxylase; Validated


Pssm-ID: 236341 [Multi-domain]  Cd Length: 405  Bit Score: 45.92  E-value: 3.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196  75 RDITCDLIVGCDGAYSTVRaHLMKKP--RFDYSQQYI--------PHGYMELTIPPKNGEYAM----EPN-CLHIWPRNA 139
Cdd:PRK08850  153 QALTAKLVVGADGANSWLR-RQMDIPltHWDYGHSALvanvrtvdPHNSVARQIFTPQGPLAFlpmsEPNmSSIVWSTEP 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196 140 FMMIALPNMDKS-FTCTLFMSFEEfeKLPTHSDVLDFFqknfpdAIPLMGEQAlmRDFfllpaqpmisvkcspfhLKSRC 218
Cdd:PRK08850  232 LRAEALLAMSDEqFNKALTAEFDN--RLGLCEVVGERQ------AFPLKMRYA--RDF-----------------VRERV 284

                         170       180
                  ....*....|....*....|....
gi 1958673196 219 VLMGDAAHAIVPFFGQGMNAGFED 242
Cdd:PRK08850  285 ALVGDAAHTIHPLAGQGVNLGLLD 308
PRK07608 PRK07608
UbiH/UbiF family hydroxylase;
215-242 3.52e-05

UbiH/UbiF family hydroxylase;


Pssm-ID: 181057 [Multi-domain]  Cd Length: 388  Bit Score: 45.72  E-value: 3.52e-05
                          10        20
                  ....*....|....*....|....*...
gi 1958673196 215 KSRCVLMGDAAHAIVPFFGQGMNAGFED 242
Cdd:PRK07608  279 APRVALVGDAAHLIHPLAGQGMNLGLRD 306
PRK07045 PRK07045
putative monooxygenase; Reviewed
 215-275 6.20e-05

putative monooxygenase; Reviewed


Pssm-ID: 136171 [Multi-domain]  Cd Length: 388  Bit Score: 44.90  E-value: 6.20e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958673196 215 KSRCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNND---LSVCLPEFSRFRIPDDHAI 275
Cdd:PRK07045  284 KRNVVLLGDAAHSIHPITGQGMNLAIEDAGELGACLDLHLSGqiaLADALERFERIRRPVNEAV 347
PRK08013 PRK08013
oxidoreductase; Provisional
 217-242 1.66e-04

oxidoreductase; Provisional


Pssm-ID: 236139 [Multi-domain]  Cd Length: 400  Bit Score: 43.50  E-value: 1.66e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958673196 217 RCVLMGDAAHAIVPFFGQGMNAGFED 242
Cdd:PRK08013  283 RLALVGDAAHTIHPLAGQGVNLGFMD 308
PRK05714 PRK05714
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional
 220-275 1.71e-04

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional


Pssm-ID: 168201 [Multi-domain]  Cd Length: 405  Bit Score: 43.66  E-value: 1.71e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958673196 220 LMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNN------DLSVcLPEFSRFRIPDDHAI 275
Cdd:PRK05714  289 LIGDAAHTIHPLAGQGVNLGFLDAAVLAEVLLHAAErgerlaDVRV-LSRFERRRMPHNLAL 349
PRK06847 PRK06847
hypothetical protein; Provisional
 80-270 4.20e-04

hypothetical protein; Provisional


Pssm-ID: 235874 [Multi-domain]  Cd Length: 375  Bit Score: 42.17  E-value: 4.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196  80 DLIVGCDGAYSTVRAHLM---KKPRF----------------DYSQQYIP-------------HGYMELTIPPKNGEYaM 127
Cdd:PRK06847  153 DLVVGADGLYSKVRSLVFpdePEPEYtgqgvwravlprpaevDRSLMYLGpttkagvvplsedLMYLFVTEPRPDNPR-I 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958673196 128 EPnclHIWPRnafmmiALPNMDKSFTctlfmsfeefeklpthSDVLDFFQKNFPDAiplmgEQALMRDF--FLLPAqpmi 205
Cdd:PRK06847  232 EP---DTLAA------LLRELLAPFG----------------GPVLQELREQITDD-----AQVVYRPLetLLVPA---- 277

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958673196 206 svkcsPFHlKSRCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKfNNDLSVCLPEFSRFRIP 270
Cdd:PRK06847  278 -----PWH-RGRVVLIGDAAHATTPHLAQGAGMAIEDAIVLAEELAR-HDSLEAALQAYYARRWE 335
PRK07333 PRK07333
ubiquinone biosynthesis hydroxylase;
215-242 5.45e-04

ubiquinone biosynthesis hydroxylase;


Pssm-ID: 180935 [Multi-domain]  Cd Length: 403  Bit Score: 41.89  E-value: 5.45e-04
                          10        20
                  ....*....|....*....|....*...
gi 1958673196 215 KSRCVLMGDAAHAIVPFFGQGMNAGFED 242
Cdd:PRK07333  279 APRFALVGDAAHGIHPIAGQGLNLGLKD 306
PRK07538 PRK07538
hypothetical protein; Provisional
 23-96 6.98e-04

hypothetical protein; Provisional


Pssm-ID: 236046 [Multi-domain]  Cd Length: 413  Bit Score: 41.81  E-value: 6.98e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958673196  23 QYilSISREKLNKDLLTAV-ESYPNAKVHFGHKLSKCCP-EEGILTMLGPN--KVPRDITCDLIVGCDGAYSTVRAHL 96
Cdd:PRK07538   96 QY--SIHRGELQMLLLDAVrERLGPDAVRTGHRVVGFEQdADVTVVFLGDRagGDLVSVRGDVLIGADGIHSAVRAQL 171
PRK06475 PRK06475
FAD-binding protein;
203-270 1.11e-03

FAD-binding protein;


Pssm-ID: 180582 [Multi-domain]  Cd Length: 400  Bit Score: 40.96  E-value: 1.11e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958673196 203 PMISVKCSPFHLKSRCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDkfNNDLSVCLPEFSRFRIP 270
Cdd:PRK06475  279 PLFEMADAQFVGPDRTIFLGDASHAVTPFAAQGAAMAIEDAAALAEALD--SDDQSAGLKRFDSVRKE 344
ubiF PRK08020
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed
 219-251 1.67e-03

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed


Pssm-ID: 181199 [Multi-domain]  Cd Length: 391  Bit Score: 40.35  E-value: 1.67e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1958673196 219 VLMGDAAHAIVPFFGQGMNAGFEDClvfDELMD 251
Cdd:PRK08020  284 ALVGDAAHTINPLAGQGVNLGYRDV---DALLD 313
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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