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Conserved domains on  [gi|1958671866|ref|XP_038946447|]
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SLAM family member 9 isoform X1 [Rattus norvegicus]

Protein Classification

Ig_SLAM-CD84_like_N domain-containing protein( domain architecture ID 11617245)

Ig_SLAM-CD84_like_N domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
27-128 5.26e-35

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


:

Pssm-ID: 409517  Cd Length: 102  Bit Score: 118.96  E-value: 5.26e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671866  27 EVVAVLQESVNLSLEIPSNEEIDNIIWFSQKNLATVMPGKEGQRVILMSvDPRYQGRVSIPESSYSLCISNLTWEDSGLY 106
Cdd:cd16842     2 EVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPGEGGAPEIIIT-DKSYKERLNISQNDYSLQISNLTMEDAGSY 80
                          90       100
                  ....*....|....*....|..
gi 1958671866 107 QAQVNLKTSQLLITKSYSLHVY 128
Cdd:cd16842    81 RARINTKNSRVTITKEFTLHIY 102
 
Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
27-128 5.26e-35

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 118.96  E-value: 5.26e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671866  27 EVVAVLQESVNLSLEIPSNEEIDNIIWFSQKNLATVMPGKEGQRVILMSvDPRYQGRVSIPESSYSLCISNLTWEDSGLY 106
Cdd:cd16842     2 EVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPGEGGAPEIIIT-DKSYKERLNISQNDYSLQISNLTMEDAGSY 80
                          90       100
                  ....*....|....*....|..
gi 1958671866 107 QAQVNLKTSQLLITKSYSLHVY 128
Cdd:cd16842    81 RARINTKNSRVTITKEFTLHIY 102
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
23-111 6.94e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 51.30  E-value: 6.94e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671866  23 EDPEEVVAVLQESVNLSLEIPS--NEEIDNIIWFSQKnlatvmPGKEGQRVILMSV--------DPRYQGRVSIPESSYS 92
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSsmSEASTSVYWYRQP------PGKGPTFLIAYYSngseegvkKGRFSGRGDPSNGDGS 74
                          90
                  ....*....|....*....
gi 1958671866  93 LCISNLTWEDSGLYQAQVN 111
Cdd:pfam07686  75 LTIQNLTLSDSGTYTCAVI 93
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
25-127 2.38e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 35.56  E-value: 2.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671866   25 PEEVVAVLQESVNLSLEIPSNEEiDNIIWFSQKNlatvmpgkegqrvILMSVDPRYQGRVSipESSYSLCISNLTWEDSG 104
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPP-PEVTWYKQGG-------------KLLAESGRFSVSRS--GSTSTLTISNVTPEDSG 64
                           90       100
                   ....*....|....*....|...
gi 1958671866  105 LYQAQVnlKTSQLLITKSYSLHV 127
Cdd:smart00410  65 TYTCAA--TNSSGSASSGTTLTV 85
 
Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
27-128 5.26e-35

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 118.96  E-value: 5.26e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671866  27 EVVAVLQESVNLSLEIPSNEEIDNIIWFSQKNLATVMPGKEGQRVILMSvDPRYQGRVSIPESSYSLCISNLTWEDSGLY 106
Cdd:cd16842     2 EVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPGEGGAPEIIIT-DKSYKERLNISQNDYSLQISNLTMEDAGSY 80
                          90       100
                  ....*....|....*....|..
gi 1958671866 107 QAQVNLKTSQLLITKSYSLHVY 128
Cdd:cd16842    81 RARINTKNSRVTITKEFTLHIY 102
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
23-111 6.94e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 51.30  E-value: 6.94e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671866  23 EDPEEVVAVLQESVNLSLEIPS--NEEIDNIIWFSQKnlatvmPGKEGQRVILMSV--------DPRYQGRVSIPESSYS 92
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSsmSEASTSVYWYRQP------PGKGPTFLIAYYSngseegvkKGRFSGRGDPSNGDGS 74
                          90
                  ....*....|....*....
gi 1958671866  93 LCISNLTWEDSGLYQAQVN 111
Cdd:pfam07686  75 LTIQNLTLSDSGTYTCAVI 93
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
26-128 2.63e-08

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 49.65  E-value: 2.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671866  26 EEVVAVLQESVNLSLEIpSNEEIDNIIWFSQKNLATVMPGKEGQRVIlmsvdPRYQGRVSIPESSYSLCISNLTWEDSGL 105
Cdd:cd05775     3 GEVYGALGGNVTLTISS-LQDDIDEIKWKKTKDKIVEWENNIGPTYF-----GSFKDRVLLDKESGSLTIKNLTKEDSGT 76
                          90       100
                  ....*....|....*....|...
gi 1958671866 106 YQAQVnLKTSQLLITKSYSLHVY 128
Cdd:cd05775    77 YELEI-TSTNGKVLSSKFTLEVL 98
IgV_CD86 cd16087
Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86; The members here ...
43-119 3.60e-05

Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86; The members here are composed of the immunoglobulin variable region (IgV) in the Cluster of Differentiation (CD) 86). Glycoproteins B7-1 (also known as cluster of differentiation (CD) 80) and B7-2 (also known as CD86) are expressed on antigen-presenting cells and deliver the co-stimulatory signal through CD28 and CTLA-4 (also known as CD152) on T cells. signaling through CD28 augments the T-cell response, whereas CTLA-4 signaling attenuates it. The CTLA-4 and B7-2 monomers are both two-layer beta-sandwiches that display the chain topology characteristic of the immunoglobulin variable (V-type) domains present in antigen receptors. The front and back sheets of B7-2 are composed of AGFCC'C" and BED strands, respectively. Members of the IgV family are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409508  Cd Length: 108  Bit Score: 41.16  E-value: 3.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671866  43 PSNEEIDNIIWFSQKN----LATVMPGKEgqrvILMSVDPRYQGRVSIPESSYSLCISNLTWEDSGLYQAQVNLKTSQLL 118
Cdd:cd16087    20 PQNISLSELVVFWQDQkklvLYELYLGKE----KLDNVNSKYIGRTSFDQENWTLQLHNVQIKDQGTYQCFIHHKSPKGL 95

                  .
gi 1958671866 119 I 119
Cdd:cd16087    96 V 96
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
25-106 1.96e-04

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 39.35  E-value: 1.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671866  25 PEEVVAVLQESVNL--SLEIPSNEEIDNIIWF-----SQKNLATVMPgKEGqrvilMSVDPRYQGRVSIPESSY-----S 92
Cdd:cd05718     6 PTEVTGFLGGSVTLpcSLTSPGTTKITQVTWMkigagSSQNVAVFHP-QYG-----PSVPNPYAERVEFLAARLglrnaT 79
                          90
                  ....*....|....
gi 1958671866  93 LCISNLTWEDSGLY 106
Cdd:cd05718    80 LRIRNLRVEDEGNY 93
IgV_1_MRC-OX-2_like cd05846
First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains; ...
29-106 4.92e-04

First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins. MRC OX-2 is a membrane glycoprotein expressed in a variety of lymphoid and non-lymphoid cells in rats. It has a similar broad distribution pattern in humans. MRC OX-2 may regulate myeloid cell activity. The protein has an extracellular portion containing two Ig-like domains, a transmembrane portion, and a cytoplasmic portion.


Pssm-ID: 409433  Cd Length: 108  Bit Score: 38.09  E-value: 4.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671866  29 VAVLQESVNLSLEIPSNEEIDNIIWfsQK-------NLATVMPgKEGQRVIlmsvdPRYQGRVSIPES---SYSLCISNL 98
Cdd:cd05846     9 RAVLGGNATLSCNLTLPEEVLQVTW--QKikasspeNIVTYSK-KYGVKIQ-----PSYVRRISFTSSglnSTSITIWNV 80

                  ....*...
gi 1958671866  99 TWEDSGLY 106
Cdd:cd05846    81 TLEDEGCY 88
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
25-127 2.38e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 35.56  E-value: 2.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671866   25 PEEVVAVLQESVNLSLEIPSNEEiDNIIWFSQKNlatvmpgkegqrvILMSVDPRYQGRVSipESSYSLCISNLTWEDSG 104
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPP-PEVTWYKQGG-------------KLLAESGRFSVSRS--GSTSTLTISNVTPEDSG 64
                           90       100
                   ....*....|....*....|...
gi 1958671866  105 LYQAQVnlKTSQLLITKSYSLHV 127
Cdd:smart00410  65 TYTCAA--TNSSGSASSGTTLTV 85
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
25-106 3.73e-03

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 35.77  E-value: 3.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671866  25 PEEVVAVLQESVNLSLEIPSNEEIDNIIWFSQKnlatvmPGKEGQRVILMS-----VDPRYQGRVSI---PESSYSLCIS 96
Cdd:cd00099     5 PRSLSVQEGESVTLSCEVSSSFSSTYIYWYRQK------PGQGPEFLIYLSsskgkTKGGVPGRFSGsrdGTSSFSLTIS 78
                          90
                  ....*....|
gi 1958671866  97 NLTWEDSGLY 106
Cdd:cd00099    79 NLQPEDSGTY 88
Ig_CSPGs_LP_like cd05714
Immunoglobulin (Ig)-like domain of chondroitin sulfate proteoglycans (CSPGs), human cartilage ...
80-110 6.35e-03

Immunoglobulin (Ig)-like domain of chondroitin sulfate proteoglycans (CSPGs), human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in chondroitin sulfate proteoglycans (CSPGs) and human cartilage link protein (LP). Included in this group are the CSPGs aggrecan, versican, and neurocan. In CSPGs, this Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggrecan and versican have a wide distribution in connective tissue and extracellular matrices. Neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. There is considerable evidence that HA-binding CSPGs are involved in developmental processes in the central nervous system. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409379  Cd Length: 123  Bit Score: 35.26  E-value: 6.35e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1958671866  80 YQGRVSIP-----ESSYSLCISNLTWEDSGLYQAQV 110
Cdd:cd05714    68 YGGRVSVPlkpgsDSDASLVITDLTASDYGLYRCEV 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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