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Conserved domains on  [gi|1958671537|ref|XP_038946319|]
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tenascin-R isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 1134-1342 3.88e-119

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


:

Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 370.03  E-value: 3.88e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537 1134 HPQDCAQHLMNGDTLSGVYTIFLNGElSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLD 1213
Cdd:cd00087      2 LPRDCSEVLQRGGRTSGVYTIQPPGS-NEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537 1214 NIHRITAQGRYELRVDMRDG-QEAVFAYYDKFAVEDSRSLYKLRIGGYNGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAM 1292
Cdd:cd00087     81 KIHLLTSQGPYELRIDLEDWeGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCAE 160

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958671537 1293 SYKGAWWYKNCHRTNLNGKYGESRH----SQGINWYHWKGHEFSIPFVEMKMRP 1342
Cdd:cd00087    161 SYSGGWWYNSCHASNLNGRYYSGGHrneyDNGINWATWKGSTYSLKFTEMKIRP 214
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
355-934 1.53e-20

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 97.77  E-value: 1.53e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  355 YVISYQPTALGGLQLQQRVPGDWSGVTITELEPGLTYNISVYAVISNILSLPITAKVATHL--STPQGLQFKTITETTVE 432
Cdd:COG3401      1 TGSSYLTSLDAGIAASAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLssGGGLGTGGRAGTTSGVA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  433 VQWEPFSFSFDGWEISFTPKNNEGGVIAqlPSDVTSFNQTGLKPGEEYIVNVVALKEQARSPPTSASVSTVIDGPTqilv 512
Cdd:COG3401     81 AVAVAAAPPTATGLTTLTGSGSVGGATN--TGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGAN---- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  513 rdVSDTVAFVEWTPPRAKVDFillkyGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTNESDASS----T 588
Cdd:COG3401    155 --ASGTTASSVAGAGVVVSPD-----TSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNevsvT 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  589 QFTTEIDAPKNLRVGSRTATSLDLEWD-NSEAEAQEYKVVYSTLAGEQYHEvlvpkgIGPTTKTTLTD--LVPGTEYGVG 665
Cdd:COG3401    228 TPTTPPSAPTGLTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPFTK------VATVTTTSYTDtgLTNGTTYYYR 301

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  666 ISAVMN----SKQSIPATMNARTEL-DSPRDLMVTASSETSISLIWTKASGP-IDHYRIT-FTPSSGISSEVTVPRDRTS 738
Cdd:COG3401    302 VTAVDAagneSAPSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTASSDAdVTGYNVYrSTSGGGTYTKIAETVTTTS 381

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  739 YTLTDLEPGAEYIISITA--ERGRQQSLESTVDAFTGFRPIShlhfshvtSSSVNITWSDPSPPADRLILNYSPRDEEEE 816
Cdd:COG3401    382 YTDTGLTPGTTYYYKVTAvdAAGNESAPSEEVSATTASAASG--------ESLTASVDAVPLTDVAGATAAASAASNPGV 453

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  817 MMEVLLDATKRHAVlmglqpATEYIVNLVAVHGTVTSEPIVGSITTGIDPPKNITISNVTKDSLTVSWSPPVAPFdYYRV 896
Cdd:COG3401    454 SAAVLADGGDTGNA------VPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGG-APDG 526

                          570       580       590
                   ....*....|....*....|....*....|....*...
gi 1958671537  897 SYRPTQVGRLDSSVVPNTVTEFTITRLYPATEYEISLN 934
Cdd:COG3401    527 TPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGA 564
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 203-231 7.27e-16

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


:

Pssm-ID: 376143  Cd Length: 29  Bit Score: 72.33  E-value: 7.27e-16
                           10        20
                   ....*....|....*....|....*....
gi 1958671537  203 YCPLGCSSRGVCVDGQCICDSEYSGDDCS 231
Cdd:pfam18720    1 YCPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1042-1127 2.75e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 2.75e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537 1042 DPPANLTASEVTRQSALISWQPPR---AAIENYVLTYKSTDGSRKELI--VDAEDTWIRLEGLSENTDYTVLLQAAQEAT 1116
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1958671537 1117 RS-SLTSTIFTT 1127
Cdd:cd00063     82 ESpPSESVTVTT 93
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 235-261 1.62e-08

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 51.53  E-value: 1.62e-08
                           10        20
                   ....*....|....*....|....*..
gi 1958671537  235 CPTDCSSRGLCVDGECVCEEPYTGEDC 261
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
fn3 pfam00041
Fibronectin type III domain;
954-1026 6.10e-08

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 51.26  E-value: 6.10e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  954 DSPMDLIATNITPTEALLQWKAPM---GEVENYVIvltHFAMAGE-----TILVDGVSEEFQLVDLLPRTHYTVTMYATS 1025
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEV---EYRPKNSgepwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   .
gi 1958671537 1026 G 1026
Cdd:pfam00041   78 G 78
C_rich_MXAN6577 super family cl49352
MXAN_6577-like cysteine-rich domain;
207-317 8.99e-08

MXAN_6577-like cysteine-rich domain;


The actual alignment was detected with superfamily member NF041328:

Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 52.84  E-value: 8.99e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  207 GCSSRG-VCVDGQCICdseysGDDCSELR--------CPTDCSSRGLCVDGECVCEEPYT--GEDCRELRC-PGDCSGKG 274
Cdd:NF041328    13 GCPEPGaVCPEGLSVC-----GGACVDLRsdpsncgaCGVACGAGQTCVAGACGCGPGTVacGGACVDTASdPAHCGACG 87

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958671537  275 Q-------CANGTCL--CQEGYAgeDCSqRRCLNACSGRGHCqeGLC--ICEEG 317
Cdd:NF041328    88 AacapgqvCEGGACReaCSEGLT--RCG-GACVDLATDPLHC--GACgvACDPG 136
 
Name Accession Description Interval E-value
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 1134-1342 3.88e-119

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 370.03  E-value: 3.88e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537 1134 HPQDCAQHLMNGDTLSGVYTIFLNGElSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLD 1213
Cdd:cd00087      2 LPRDCSEVLQRGGRTSGVYTIQPPGS-NEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537 1214 NIHRITAQGRYELRVDMRDG-QEAVFAYYDKFAVEDSRSLYKLRIGGYNGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAM 1292
Cdd:cd00087     81 KIHLLTSQGPYELRIDLEDWeGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCAE 160

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958671537 1293 SYKGAWWYKNCHRTNLNGKYGESRH----SQGINWYHWKGHEFSIPFVEMKMRP 1342
Cdd:cd00087    161 SYSGGWWYNSCHASNLNGRYYSGGHrneyDNGINWATWKGSTYSLKFTEMKIRP 214
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 1134-1343 5.80e-119

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 369.30  E-value: 5.80e-119
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  1134 HPQDCAQHLMNGDTLSGVYTIFLNGElSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLD 1213
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGS-SRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  1214 NIHRITAQGRYELRVDMRD-GQEAVFAYYDKFAVEDSRSLYKLRIGGYNGTAGD-SLSYHQGRPFSTEDRDNDVAVTNCA 1291
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEDwEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1958671537  1292 MSYKGAWWYKNCHRTNLNGKYG-ESRHSQGINWYHWKGHEFSIPFVEMKMRPY 1343
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
1135-1343 4.26e-99

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 315.62  E-value: 4.26e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537 1135 PQDCAQHLMNGDTLSGVYTIFLNGELShKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLE-DEFWLGLD 1213
Cdd:pfam00147    2 GRDCSDVYNKGAKTSGLYTIRPDGATK-PFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGND 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537 1214 NIHRITAQGRYELRVDMRDGQ-EAVFAYYDKFAVEDSRSLYKLRIGGYNGTAGD-------SLSYHQGRPFSTEDRDNDV 1285
Cdd:pfam00147   81 KIHLLTKQGPYVLRIDLEDWNgETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDNDS 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958671537 1286 AVTNCAMSYKGAWWYKNCHRTNLNGKY--GESRHSQ-GINWYHWKGHEFSIPFVEMKMRPY 1343
Cdd:pfam00147  161 PDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
355-934 1.53e-20

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 97.77  E-value: 1.53e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  355 YVISYQPTALGGLQLQQRVPGDWSGVTITELEPGLTYNISVYAVISNILSLPITAKVATHL--STPQGLQFKTITETTVE 432
Cdd:COG3401      1 TGSSYLTSLDAGIAASAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLssGGGLGTGGRAGTTSGVA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  433 VQWEPFSFSFDGWEISFTPKNNEGGVIAqlPSDVTSFNQTGLKPGEEYIVNVVALKEQARSPPTSASVSTVIDGPTqilv 512
Cdd:COG3401     81 AVAVAAAPPTATGLTTLTGSGSVGGATN--TGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGAN---- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  513 rdVSDTVAFVEWTPPRAKVDFillkyGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTNESDASS----T 588
Cdd:COG3401    155 --ASGTTASSVAGAGVVVSPD-----TSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNevsvT 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  589 QFTTEIDAPKNLRVGSRTATSLDLEWD-NSEAEAQEYKVVYSTLAGEQYHEvlvpkgIGPTTKTTLTD--LVPGTEYGVG 665
Cdd:COG3401    228 TPTTPPSAPTGLTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPFTK------VATVTTTSYTDtgLTNGTTYYYR 301

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  666 ISAVMN----SKQSIPATMNARTEL-DSPRDLMVTASSETSISLIWTKASGP-IDHYRIT-FTPSSGISSEVTVPRDRTS 738
Cdd:COG3401    302 VTAVDAagneSAPSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTASSDAdVTGYNVYrSTSGGGTYTKIAETVTTTS 381

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  739 YTLTDLEPGAEYIISITA--ERGRQQSLESTVDAFTGFRPIShlhfshvtSSSVNITWSDPSPPADRLILNYSPRDEEEE 816
Cdd:COG3401    382 YTDTGLTPGTTYYYKVTAvdAAGNESAPSEEVSATTASAASG--------ESLTASVDAVPLTDVAGATAAASAASNPGV 453

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  817 MMEVLLDATKRHAVlmglqpATEYIVNLVAVHGTVTSEPIVGSITTGIDPPKNITISNVTKDSLTVSWSPPVAPFdYYRV 896
Cdd:COG3401    454 SAAVLADGGDTGNA------VPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGG-APDG 526

                          570       580       590
                   ....*....|....*....|....*....|....*...
gi 1958671537  897 SYRPTQVGRLDSSVVPNTVTEFTITRLYPATEYEISLN 934
Cdd:COG3401    527 TPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGA 564
fn3 pfam00041
Fibronectin type III domain;
865-944 2.89e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 75.14  E-value: 2.89e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  865 DPPKNITISNVTKDSLTVSWSPPV---APFDYYRVSYRPTQVGRLDSSV-VPNTVTEFTITRLYPATEYEISLNSVRGRE 940
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1958671537  941 ESER 944
Cdd:pfam00041   81 EGPP 84
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 203-231 7.27e-16

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 72.33  E-value: 7.27e-16
                           10        20
                   ....*....|....*....|....*....
gi 1958671537  203 YCPLGCSSRGVCVDGQCICDSEYSGDDCS 231
Cdd:pfam18720    1 YCPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 865-943 1.09e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.99  E-value: 1.09e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  865 DPPKNITISNVTKDSLTVSWSPPV---APFDYYRVSYRPTQVGR-LDSSVVPNTVTEFTITRLYPATEYEISLNSVRGRE 940
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ...
gi 1958671537  941 ESE 943
Cdd:cd00063     82 ESP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 687-763 4.12e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 66.10  E-value: 4.12e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537   687 DSPRDLMVTASSETSISLIWTKAS-----GPIDHYRITFTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITAERGRQ 761
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1958671537   762 QS 763
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1042-1127 2.75e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 2.75e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537 1042 DPPANLTASEVTRQSALISWQPPR---AAIENYVLTYKSTDGSRKELI--VDAEDTWIRLEGLSENTDYTVLLQAAQEAT 1116
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1958671537 1117 RS-SLTSTIFTT 1127
Cdd:cd00063     82 ESpPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1042-1118 9.35e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 59.17  E-value: 9.35e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  1042 DPPANLTASEVTRQSALISWQPPRAA-----IENYVLTYKSTDGSRKELIVDAEDTWIRLEGLSENTDYTVLLQAAQEAT 1116
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1958671537  1117 RS 1118
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
1042-1111 2.04e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 2.04e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958671537 1042 DPPANLTASEVTRQSALISWQPPR---AAIENYVLTYKSTDGSR--KELIVDAEDTWIRLEGLSENTDYTVLLQA 1111
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 1138-1177 1.02e-08

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 52.18  E-value: 1.02e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958671537 1138 CAQ-HLMNGDTLSGVYTIFLNGELSHK-LQVYCDMTTDGGGW 1177
Cdd:NF040941     2 CWEiLQAGPSAPSGVYWIDPDGMGGLApFQVYCDMTTDGGGW 43
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 235-261 1.62e-08

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 51.53  E-value: 1.62e-08
                           10        20
                   ....*....|....*....|....*..
gi 1958671537  235 CPTDCSSRGLCVDGECVCEEPYTGEDC 261
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
fn3 pfam00041
Fibronectin type III domain;
954-1026 6.10e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 51.26  E-value: 6.10e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  954 DSPMDLIATNITPTEALLQWKAPM---GEVENYVIvltHFAMAGE-----TILVDGVSEEFQLVDLLPRTHYTVTMYATS 1025
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEV---EYRPKNSgepwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   .
gi 1958671537 1026 G 1026
Cdd:pfam00041   78 G 78
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
207-317 8.99e-08

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 52.84  E-value: 8.99e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  207 GCSSRG-VCVDGQCICdseysGDDCSELR--------CPTDCSSRGLCVDGECVCEEPYT--GEDCRELRC-PGDCSGKG 274
Cdd:NF041328    13 GCPEPGaVCPEGLSVC-----GGACVDLRsdpsncgaCGVACGAGQTCVAGACGCGPGTVacGGACVDTASdPAHCGACG 87

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958671537  275 Q-------CANGTCL--CQEGYAgeDCSqRRCLNACSGRGHCqeGLC--ICEEG 317
Cdd:NF041328    88 AacapgqvCEGGACReaCSEGLT--RCG-GACVDLATDPLHC--GACgvACDPG 136
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 954-1026 9.90e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.91  E-value: 9.90e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958671537   954 DSPMDLIATNITPTEALLQWKAP-----MGEVENYVIVLTHFAMAGETILVDGVSEEFQLVDLLPRTHYTVTMYATSG 1026
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 954-1035 2.85e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.02  E-value: 2.85e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  954 DSPMDLIATNITPTEALLQWKAP---MGEVENYVIVLT-HFAMAGETILVDGVSE-EFQLVDLLPRTHYTVTMYA----- 1023
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYReKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAvnggg 81

                           90
                   ....*....|..
gi 1958671537 1024 TSGPLVSGTIAT 1035
Cdd:cd00063     82 ESPPSESVTVTT 93
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 300-323 3.51e-05

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 41.95  E-value: 3.51e-05
                           10        20
                   ....*....|....*....|....*.
gi 1958671537  300 ACSGRGHC--QEGLCICEEGYQGPDC 323
Cdd:pfam07974    1 ICSGRGTCvnQCGKCVCDSGYQGATC 26
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
784-1127 2.22e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 45.76  E-value: 2.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  784 HVTSSSVNITWSDPSPPADRLILNYSPRDEEEEMMEVLLDATKRHAVLMGLQPATEYIVNLV---------AVHGTVTSE 854
Cdd:COG3401     45 SVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGAtntgltssdEVPSPAVGT 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  855 PIVGSITTGIDPPKNITISNVTK---DSLTVSWSPPVAPFDYYRVSYRPTQVG---RLDSSVVPNTVTEFTITRLYPATE 928
Cdd:COG3401    125 ATTATAVAGGAATAGTYALGAGLygvDGANASGTTASSVAGAGVVVSPDTSATaavATTSLTVTSTTLVDGGGDIEPGTT 204

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  929 YEISL---NSVRGREESERIC-TLVHTAMDSPMDLIATNITPTEALLQWKAPMGE-VENYVIVLTHFAMAGETILVDGVS 1003
Cdd:COG3401    205 YYYRVaatDTGGESAPSNEVSvTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFTKVATVTT 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537 1004 EEFQLVDLLPRT--HYTVTMYATSG------PLVSGTIATnfsTLLDPPANLTASEVTRQSALISWQPPRAA-IENYVLT 1074
Cdd:COG3401    285 TSYTDTGLTNGTtyYYRVTAVDAAGnesapsNVVSVTTDL---TPPAAPSGLTATAVGSSSITLSWTASSDAdVTGYNVY 361

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958671537 1075 YKSTDGSRKELIVD-AEDTWIRLEGLSENTDYTVLLQAAQEATRSSLTSTIFTT 1127
Cdd:COG3401    362 RSTSGGGTYTKIAEtVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSA 415
 
Name Accession Description Interval E-value
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 1134-1342 3.88e-119

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 370.03  E-value: 3.88e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537 1134 HPQDCAQHLMNGDTLSGVYTIFLNGElSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLD 1213
Cdd:cd00087      2 LPRDCSEVLQRGGRTSGVYTIQPPGS-NEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537 1214 NIHRITAQGRYELRVDMRDG-QEAVFAYYDKFAVEDSRSLYKLRIGGYNGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAM 1292
Cdd:cd00087     81 KIHLLTSQGPYELRIDLEDWeGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCAE 160

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958671537 1293 SYKGAWWYKNCHRTNLNGKYGESRH----SQGINWYHWKGHEFSIPFVEMKMRP 1342
Cdd:cd00087    161 SYSGGWWYNSCHASNLNGRYYSGGHrneyDNGINWATWKGSTYSLKFTEMKIRP 214
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 1134-1343 5.80e-119

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 369.30  E-value: 5.80e-119
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  1134 HPQDCAQHLMNGDTLSGVYTIFLNGElSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLD 1213
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGS-SRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  1214 NIHRITAQGRYELRVDMRD-GQEAVFAYYDKFAVEDSRSLYKLRIGGYNGTAGD-SLSYHQGRPFSTEDRDNDVAVTNCA 1291
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEDwEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1958671537  1292 MSYKGAWWYKNCHRTNLNGKYG-ESRHSQGINWYHWKGHEFSIPFVEMKMRPY 1343
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
1135-1343 4.26e-99

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 315.62  E-value: 4.26e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537 1135 PQDCAQHLMNGDTLSGVYTIFLNGELShKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLE-DEFWLGLD 1213
Cdd:pfam00147    2 GRDCSDVYNKGAKTSGLYTIRPDGATK-PFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGND 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537 1214 NIHRITAQGRYELRVDMRDGQ-EAVFAYYDKFAVEDSRSLYKLRIGGYNGTAGD-------SLSYHQGRPFSTEDRDNDV 1285
Cdd:pfam00147   81 KIHLLTKQGPYVLRIDLEDWNgETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDNDS 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958671537 1286 AVTNCAMSYKGAWWYKNCHRTNLNGKY--GESRHSQ-GINWYHWKGHEFSIPFVEMKMRPY 1343
Cdd:pfam00147  161 PDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
355-934 1.53e-20

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 97.77  E-value: 1.53e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  355 YVISYQPTALGGLQLQQRVPGDWSGVTITELEPGLTYNISVYAVISNILSLPITAKVATHL--STPQGLQFKTITETTVE 432
Cdd:COG3401      1 TGSSYLTSLDAGIAASAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLssGGGLGTGGRAGTTSGVA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  433 VQWEPFSFSFDGWEISFTPKNNEGGVIAqlPSDVTSFNQTGLKPGEEYIVNVVALKEQARSPPTSASVSTVIDGPTqilv 512
Cdd:COG3401     81 AVAVAAAPPTATGLTTLTGSGSVGGATN--TGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGAN---- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  513 rdVSDTVAFVEWTPPRAKVDFillkyGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTNESDASS----T 588
Cdd:COG3401    155 --ASGTTASSVAGAGVVVSPD-----TSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNevsvT 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  589 QFTTEIDAPKNLRVGSRTATSLDLEWD-NSEAEAQEYKVVYSTLAGEQYHEvlvpkgIGPTTKTTLTD--LVPGTEYGVG 665
Cdd:COG3401    228 TPTTPPSAPTGLTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPFTK------VATVTTTSYTDtgLTNGTTYYYR 301

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  666 ISAVMN----SKQSIPATMNARTEL-DSPRDLMVTASSETSISLIWTKASGP-IDHYRIT-FTPSSGISSEVTVPRDRTS 738
Cdd:COG3401    302 VTAVDAagneSAPSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTASSDAdVTGYNVYrSTSGGGTYTKIAETVTTTS 381

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  739 YTLTDLEPGAEYIISITA--ERGRQQSLESTVDAFTGFRPIShlhfshvtSSSVNITWSDPSPPADRLILNYSPRDEEEE 816
Cdd:COG3401    382 YTDTGLTPGTTYYYKVTAvdAAGNESAPSEEVSATTASAASG--------ESLTASVDAVPLTDVAGATAAASAASNPGV 453

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  817 MMEVLLDATKRHAVlmglqpATEYIVNLVAVHGTVTSEPIVGSITTGIDPPKNITISNVTKDSLTVSWSPPVAPFdYYRV 896
Cdd:COG3401    454 SAAVLADGGDTGNA------VPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGG-APDG 526

                          570       580       590
                   ....*....|....*....|....*....|....*...
gi 1958671537  897 SYRPTQVGRLDSSVVPNTVTEFTITRLYPATEYEISLN 934
Cdd:COG3401    527 TPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGA 564
fn3 pfam00041
Fibronectin type III domain;
865-944 2.89e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 75.14  E-value: 2.89e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  865 DPPKNITISNVTKDSLTVSWSPPV---APFDYYRVSYRPTQVGRLDSSV-VPNTVTEFTITRLYPATEYEISLNSVRGRE 940
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1958671537  941 ESER 944
Cdd:pfam00041   81 EGPP 84
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 203-231 7.27e-16

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 72.33  E-value: 7.27e-16
                           10        20
                   ....*....|....*....|....*....
gi 1958671537  203 YCPLGCSSRGVCVDGQCICDSEYSGDDCS 231
Cdd:pfam18720    1 YCPLGCSSRGVCVDGQCICDSEYSGDDCS 29
fn3 pfam00041
Fibronectin type III domain;
687-766 4.02e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 71.68  E-value: 4.02e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  687 DSPRDLMVTASSETSISLIWTKA---SGPIDHYRITFTPSSGISS--EVTVPRDRTSYTLTDLEPGAEYIISITAERGRQ 761
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 1958671537  762 QSLES 766
Cdd:pfam00041   81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 865-943 1.09e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.99  E-value: 1.09e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  865 DPPKNITISNVTKDSLTVSWSPPV---APFDYYRVSYRPTQVGR-LDSSVVPNTVTEFTITRLYPATEYEISLNSVRGRE 940
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ...
gi 1958671537  941 ESE 943
Cdd:cd00063     82 ESP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 687-772 1.70e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.52  E-value: 1.70e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  687 DSPRDLMVTASSETSISLIWTKAS---GPIDHYRITFTP-SSGISSEVTVPR-DRTSYTLTDLEPGAEYIISITAERGRQ 761
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREkGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|.
gi 1958671537  762 QSLESTVDAFT 772
Cdd:cd00063     82 ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 687-763 4.12e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 66.10  E-value: 4.12e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537   687 DSPRDLMVTASSETSISLIWTKAS-----GPIDHYRITFTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITAERGRQ 761
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1958671537   762 QS 763
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 865-942 2.68e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.79  E-value: 2.68e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537   865 DPPKNITISNVTKDSLTVSWSPP-----VAPFDYYRVSYRPTQVGRLDSSVVPNTvTEFTITRLYPATEYEISLNSVRGR 939
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSS-TSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 1958671537   940 EES 942
Cdd:smart00060   81 GEG 83
fn3 pfam00041
Fibronectin type III domain;
328-398 2.73e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.59  E-value: 2.73e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958671537  328 PPEDLRVAGISDRSIELEW----DGPMAVTEYVISYQPTALGGLQLQQRVPGDWSGVTITELEPGLTYNISVYAV 398
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWtpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
fn3 pfam00041
Fibronectin type III domain;
416-496 5.15e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 5.15e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  416 STPQGLQFKTITETTVEVQWE-PFSFS--FDGWEISFTPKNNEGGVIAQ-LPSDVTSFNQTGLKPGEEYIVNVVALKEQA 491
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTpPPDGNgpITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 1958671537  492 RSPPT 496
Cdd:pfam00041   81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 328-413 5.51e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.28  E-value: 5.51e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  328 PPEDLRVAGISDRSIELEWDGP----MAVTEYVISYQPTALGGLQLQQRVPGDWSGVTITELEPGLTYNISVYAVISNIL 403
Cdd:cd00063      3 PPTNLRVTDVTSTSVTLSWTPPeddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82

                           90
                   ....*....|
gi 1958671537  404 SLPITAKVAT 413
Cdd:cd00063     83 SPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1042-1127 2.75e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 2.75e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537 1042 DPPANLTASEVTRQSALISWQPPR---AAIENYVLTYKSTDGSRKELI--VDAEDTWIRLEGLSENTDYTVLLQAAQEAT 1116
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1958671537 1117 RS-SLTSTIFTT 1127
Cdd:cd00063     82 ESpPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
327-526 8.88e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 66.18  E-value: 8.88e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  327 TPPEDLRVAGISDRSIELEWDGP--MAVTEYVISYQPTALGGLQLQQRVPGdwSGVTITELEPGLTYNISVYAVISN--- 401
Cdd:COG3401    234 SAPTGLTATADTPGSVTLSWDPVteSDATGYRVYRSNSGDGPFTKVATVTT--TSYTDTGLTNGTTYYYRVTAVDAAgne 311

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  402 -ILSLPITAKVATHL-STPQGLQFKTITETTVEVQWEPfsfSFDGWEISF-----TPKNNEGGVIAQLPSDvTSFNQTGL 474
Cdd:COG3401    312 sAPSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTA---SSDADVTGYnvyrsTSGGGTYTKIAETVTT-TSYTDTGL 387

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958671537  475 KPGEEYIVNVVAL----KEQARSPPTSASVSTVIDGPTQILVRDVSDTVAFVEWTP 526
Cdd:COG3401    388 TPGTTYYYKVTAVdaagNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATA 443
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1042-1118 9.35e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 59.17  E-value: 9.35e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  1042 DPPANLTASEVTRQSALISWQPPRAA-----IENYVLTYKSTDGSRKELIVDAEDTWIRLEGLSENTDYTVLLQAAQEAT 1116
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1958671537  1117 RS 1118
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
507-586 1.69e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.58  E-value: 1.69e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  507 PTQILVRDVSDTVAFVEWTPPR---AKVDFILLKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTNES 583
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 1958671537  584 DAS 586
Cdd:pfam00041   83 PPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 595-679 8.02e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 8.02e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  595 DAPKNLRVGSRTATSLDLEWD---NSEAEAQEYKVVYSTLAGEQYHEVlvPKGIGPTTKTTLTDLVPGTEYGVGISAVMN 671
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTppeDDGGPITGYVVEYREKGSGDWKEV--EVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79


                   ....*...
gi 1958671537  672 SKQSIPAT 679
Cdd:cd00063     80 GGESPPSE 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 416-503 8.58e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.74  E-value: 8.58e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  416 STPQGLQFKTITETTVEVQWEPFSFS---FDGWEISFTPKNNEGGV-IAQLPSDVTSFNQTGLKPGEEYIVNVVALKEQA 491
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKeVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1958671537  492 RSPPTSASVSTV 503
Cdd:cd00063     82 ESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
1042-1111 2.04e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 2.04e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958671537 1042 DPPANLTASEVTRQSALISWQPPR---AAIENYVLTYKSTDGSR--KELIVDAEDTWIRLEGLSENTDYTVLLQA 1111
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75
fn3 pfam00041
Fibronectin type III domain;
776-855 6.52e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.96  E-value: 6.52e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  776 PISHLHFSHVTSSSVNITWSdPSPPADRLILNYS----PRDEEEEMMEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTV 851
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWT-PPPDGNGPITGYEveyrPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1958671537  852 TSEP 855
Cdd:pfam00041   81 EGPP 84
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 1138-1177 1.02e-08

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 52.18  E-value: 1.02e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958671537 1138 CAQ-HLMNGDTLSGVYTIFLNGELSHK-LQVYCDMTTDGGGW 1177
Cdd:NF040941     2 CWEiLQAGPSAPSGVYWIDPDGMGGLApFQVYCDMTTDGGGW 43
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 328-398 1.04e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.39  E-value: 1.04e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958671537   328 PPEDLRVAGISDRSIELEWDGP--MAVTEYVISYQPTALGGLQLQQRVPGDWSG--VTITELEPGLTYNISVYAV 398
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPpdDGITGYIVGYRVEYREEGSEWKEVNVTPSStsYTLTGLKPGTEYEFRVRAV 77
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 235-261 1.62e-08

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 51.53  E-value: 1.62e-08
                           10        20
                   ....*....|....*....|....*..
gi 1958671537  235 CPTDCSSRGLCVDGECVCEEPYTGEDC 261
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 505-592 1.66e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.27  E-value: 1.66e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  505 DGPTQILVRDVSDTVAFVEWTPPRAKVDFIL---LKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTN 581
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITgyvVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1958671537  582 ESDAS-STQFTT 592
Cdd:cd00063     82 ESPPSeSVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 595-669 2.97e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.23  E-value: 2.97e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958671537   595 DAPKNLRVGSRTATSLDLEWDNSEAEAQE-YKVVYSTLAGEQYHEVLVPKGIGPTTKTTLTDLVPGTEYGVGISAV 669
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITgYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 776-862 3.70e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 3.70e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  776 PISHLHFSHVTSSSVNITWSDPSPPADRL---ILNYSPRDEEEEMMEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTVT 852
Cdd:cd00063      3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPItgyVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82

                           90
                   ....*....|.
gi 1958671537  853 SEPI-VGSITT 862
Cdd:cd00063     83 SPPSeSVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
595-669 5.59e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 51.65  E-value: 5.59e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958671537  595 DAPKNLRVGSRTATSLDLEW---DNSEAEAQEYKVVYSTLAGEQY-HEVLVPkgiGPTTKTTLTDLVPGTEYGVGISAV 669
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPwNEITVP---GTTTSVTLTGLKPGTEYEVRVQAV 76
fn3 pfam00041
Fibronectin type III domain;
954-1026 6.10e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 51.26  E-value: 6.10e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  954 DSPMDLIATNITPTEALLQWKAPM---GEVENYVIvltHFAMAGE-----TILVDGVSEEFQLVDLLPRTHYTVTMYATS 1025
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEV---EYRPKNSgepwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   .
gi 1958671537 1026 G 1026
Cdd:pfam00041   78 G 78
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
207-317 8.99e-08

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 52.84  E-value: 8.99e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  207 GCSSRG-VCVDGQCICdseysGDDCSELR--------CPTDCSSRGLCVDGECVCEEPYT--GEDCRELRC-PGDCSGKG 274
Cdd:NF041328    13 GCPEPGaVCPEGLSVC-----GGACVDLRsdpsncgaCGVACGAGQTCVAGACGCGPGTVacGGACVDTASdPAHCGACG 87

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958671537  275 Q-------CANGTCL--CQEGYAgeDCSqRRCLNACSGRGHCqeGLC--ICEEG 317
Cdd:NF041328    88 AacapgqvCEGGACReaCSEGLT--RCG-GACVDLATDPLHC--GACgvACDPG 136
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 776-847 1.57e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.31  E-value: 1.57e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958671537   776 PISHLHFSHVTSSSVNITWSDPSPPADRL-ILNYSP--RDEEEEMMEVLLDATKRHAVLMGLQPATEYIVNLVAV 847
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRVeyREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 416-486 1.19e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 1.19e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958671537   416 STPQGLQFKTITETTVEVQWEPFSFS-----FDGWEISFTPKNNEGGVIAQLPSDvTSFNQTGLKPGEEYIVNVVA 486
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSS-TSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 505-583 4.31e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.07  E-value: 4.31e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537   505 DGPTQILVRDVSDTVAFVEWTPP-RAKVDFILLKYGLVGGEGGKTTFRL--QPPLSQYSVQALRPGSRYEVSISAVRGTN 581
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1958671537   582 ES 583
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 954-1026 9.90e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.91  E-value: 9.90e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958671537   954 DSPMDLIATNITPTEALLQWKAP-----MGEVENYVIVLTHFAMAGETILVDGVSEEFQLVDLLPRTHYTVTMYATSG 1026
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 954-1035 2.85e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.02  E-value: 2.85e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  954 DSPMDLIATNITPTEALLQWKAP---MGEVENYVIVLT-HFAMAGETILVDGVSE-EFQLVDLLPRTHYTVTMYA----- 1023
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYReKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAvnggg 81

                           90
                   ....*....|..
gi 1958671537 1024 TSGPLVSGTIAT 1035
Cdd:cd00063     82 ESPPSESVTVTT 93
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 300-323 3.51e-05

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 41.95  E-value: 3.51e-05
                           10        20
                   ....*....|....*....|....*.
gi 1958671537  300 ACSGRGHC--QEGLCICEEGYQGPDC 323
Cdd:pfam07974    1 ICSGRGTCvnQCGKCVCDSGYQGATC 26
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
784-1127 2.22e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 45.76  E-value: 2.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  784 HVTSSSVNITWSDPSPPADRLILNYSPRDEEEEMMEVLLDATKRHAVLMGLQPATEYIVNLV---------AVHGTVTSE 854
Cdd:COG3401     45 SVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGAtntgltssdEVPSPAVGT 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  855 PIVGSITTGIDPPKNITISNVTK---DSLTVSWSPPVAPFDYYRVSYRPTQVG---RLDSSVVPNTVTEFTITRLYPATE 928
Cdd:COG3401    125 ATTATAVAGGAATAGTYALGAGLygvDGANASGTTASSVAGAGVVVSPDTSATaavATTSLTVTSTTLVDGGGDIEPGTT 204

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  929 YEISL---NSVRGREESERIC-TLVHTAMDSPMDLIATNITPTEALLQWKAPMGE-VENYVIVLTHFAMAGETILVDGVS 1003
Cdd:COG3401    205 YYYRVaatDTGGESAPSNEVSvTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFTKVATVTT 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537 1004 EEFQLVDLLPRT--HYTVTMYATSG------PLVSGTIATnfsTLLDPPANLTASEVTRQSALISWQPPRAA-IENYVLT 1074
Cdd:COG3401    285 TSYTDTGLTNGTtyYYRVTAVDAAGnesapsNVVSVTTDL---TPPAAPSGLTATAVGSSSITLSWTASSDAdVTGYNVY 361

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958671537 1075 YKSTDGSRKELIVD-AEDTWIRLEGLSENTDYTVLLQAAQEATRSSLTSTIFTT 1127
Cdd:COG3401    362 RSTSGGGTYTKIAEtVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSA 415
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
494-692 4.49e-04

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 44.94  E-value: 4.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  494 PPTSASVSTVIDGPTQILVRDVSDTVAFVEWTPPRAKVDF-ILLKYGlvggeGGKTTFRLQPPLSQYSVQALRPGsRYEV 572
Cdd:COG4733    528 PPQWPPVNVTTSESLSVVAQGTAVTTLTVSWDAPAGAVAYeVEWRRD-----DGNWVSVPRTSGTSFEVPGIYAG-DYEV 601

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  573 SisaVRGTNESDASS-TQFTTEID---------APKNLRVGSRTaTSLDLEWDNS-EAEAQEYKVVYSTLAGEQyhEVLV 641
Cdd:COG4733    602 R---VRAINALGVSSaWAASSETTvtgktapppAPTGLTATGGL-GGITLSWSFPvDADTLRTEIRYSTTGDWA--SATV 675

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1958671537  642 PKGIGPTTKTTLTDLVPGTEYGVGISAVMNSKQSIPATMNARTELDSPRDL 692
Cdd:COG4733    676 AQALYPGNTYTLAGLKAGQTYYYRARAVDRSGNVSAWWVSGQASADAAGIL 726
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 208-230 5.69e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.48  E-value: 5.69e-04
                           10        20
                   ....*....|....*....|....*
gi 1958671537  208 CSSRGVCVD--GQCICDSEYSGDDC 230
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 297-324 9.66e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 38.05  E-value: 9.66e-04
                           10        20
                   ....*....|....*....|....*...
gi 1958671537  297 CLNACSGRGHCQEGLCICEEGYQGPDCS 324
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
321-539 1.99e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 42.68  E-value: 1.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  321 PDCSAVTPPEDLRVAGISDRSIELEWDGPMA--VTEYVISYQPTALGGLQLQQRVPGDWSgVTITELEPGLTYNISVYAV 398
Cdd:COG3401    322 TDLTPPAAPSGLTATAVGSSSITLSWTASSDadVTGYNVYRSTSGGGTYTKIAETVTTTS-YTDTGLTPGTTYYYKVTAV 400

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958671537  399 ISNILSLPITAKV-ATHLSTPQGLQFKTITETTVEVQWEPFSFSF-------DGWEISFTPKNNEGGVIAQLPSDVTSFN 470
Cdd:COG3401    401 DAAGNESAPSEEVsATTASAASGESLTASVDAVPLTDVAGATAAAsaasnpgVSAAVLADGGDTGNAVPFTTTSSTVTAT 480

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958671537  471 QTGLKPGEEYIVNVVA-LKEQARSPPTSASVSTVIDGPTQILVRD---VSDTVAFVEWTPPRAKVDFILLKYG 539
Cdd:COG3401    481 TTDTTTANLSVTTGSLvGGSGASSVTNSVSVIGASAAAAVGGAPDgtpNVTGASPVTVGASTGDVLITDLVSL 553
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 269-292 5.45e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 35.79  E-value: 5.45e-03
                           10        20
                   ....*....|....*....|....*.
gi 1958671537  269 DCSGKGQC--ANGTCLCQEGYAGEDC 292
Cdd:pfam07974    1 ICSGRGTCvnQCGKCVCDSGYQGATC 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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