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Conserved domains on  [gi|1958649197|ref|XP_038945223|]
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beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase isoform X1 [Rattus norvegicus]

Protein Classification

beta-1,6-N-acetylglucosaminyltransferase( domain architecture ID 10494456)

beta-1,6-N-acetylglucosaminyltransferase similar to beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) and N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (EC 2.4.1.150)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Branch pfam02485
Core-2/I-Branching enzyme; This is a family of two different beta-1, ...
123-391 2.30e-74

Core-2/I-Branching enzyme; This is a family of two different beta-1,6-N-acetylglucosaminyltransferase enzymes, I-branching enzyme and core-2 branching enzyme. I-branching enzyme is responsible for the production of the blood group I-antigen during embryonic development. Core-2 branching enzyme forms crucial side-chain branches in O-glycans. This is a fmmily of glycosyl-transferases that are Type II membrane proteins that are found in the endoplasmic reticulum (ER) and Golgi apparatus.


:

Pssm-ID: 426795  Cd Length: 250  Bit Score: 232.94  E-value: 2.30e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649197 123 IAYSIVVHH-KIDMLDRLLRAIYMPQNFYCIHVDRKAEESFLAAVQGIASCFDNVFVASQLESVVYASWSRVKADLNCMK 201
Cdd:pfam02485   1 IAFMFLTYKgDLPLLELWLRFFYHPENLYSIYVDSKAPSYFRERVRALASCFFNVRVIPKSESVDWGGPSMVAAELRLLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649197 202 DLYRMNANWKYLINLCGMDFPIKTNLEIVRKLKSFTGENSL-ETEKMPPNKE-ERWKKRytVVDGKLTNTGVVKAQPPLK 279
Cdd:pfam02485  81 NLLLLDPSWDYFILLSESDIPLKTFDELYQYLSSLNGNNSFiDSFSDPGWKGrGRYKPR--ILDPMLPEIKKSKLFLPTA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649197 280 TPLFSGSAYFVVTREYVGYVLENKNIQKFMEWAQDTYSPDEFLWATIqripevpgsLPSSHKYDLSDMNAVARFVKWqyf 359
Cdd:pfam02485 159 FKWRKGSQWFVLSRAFAEYVVWDNLYYPLFKYYCDTCYPDEHYFPTL---------LCMSGEFPNTCANRTLTYVDW--- 226
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1958649197 360 egdvsNGAPYPPCSGVhvrsVCVFGVGDLSWM 391
Cdd:pfam02485 227 -----SRGGCHPKTYR----PCILGPEDLKRI 249
 
Name Accession Description Interval E-value
Branch pfam02485
Core-2/I-Branching enzyme; This is a family of two different beta-1, ...
123-391 2.30e-74

Core-2/I-Branching enzyme; This is a family of two different beta-1,6-N-acetylglucosaminyltransferase enzymes, I-branching enzyme and core-2 branching enzyme. I-branching enzyme is responsible for the production of the blood group I-antigen during embryonic development. Core-2 branching enzyme forms crucial side-chain branches in O-glycans. This is a fmmily of glycosyl-transferases that are Type II membrane proteins that are found in the endoplasmic reticulum (ER) and Golgi apparatus.


Pssm-ID: 426795  Cd Length: 250  Bit Score: 232.94  E-value: 2.30e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649197 123 IAYSIVVHH-KIDMLDRLLRAIYMPQNFYCIHVDRKAEESFLAAVQGIASCFDNVFVASQLESVVYASWSRVKADLNCMK 201
Cdd:pfam02485   1 IAFMFLTYKgDLPLLELWLRFFYHPENLYSIYVDSKAPSYFRERVRALASCFFNVRVIPKSESVDWGGPSMVAAELRLLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649197 202 DLYRMNANWKYLINLCGMDFPIKTNLEIVRKLKSFTGENSL-ETEKMPPNKE-ERWKKRytVVDGKLTNTGVVKAQPPLK 279
Cdd:pfam02485  81 NLLLLDPSWDYFILLSESDIPLKTFDELYQYLSSLNGNNSFiDSFSDPGWKGrGRYKPR--ILDPMLPEIKKSKLFLPTA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649197 280 TPLFSGSAYFVVTREYVGYVLENKNIQKFMEWAQDTYSPDEFLWATIqripevpgsLPSSHKYDLSDMNAVARFVKWqyf 359
Cdd:pfam02485 159 FKWRKGSQWFVLSRAFAEYVVWDNLYYPLFKYYCDTCYPDEHYFPTL---------LCMSGEFPNTCANRTLTYVDW--- 226
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1958649197 360 egdvsNGAPYPPCSGVhvrsVCVFGVGDLSWM 391
Cdd:pfam02485 227 -----SRGGCHPKTYR----PCILGPEDLKRI 249
PLN03183 PLN03183
acetylglucosaminyltransferase family protein; Provisional
133-331 4.90e-10

acetylglucosaminyltransferase family protein; Provisional


Pssm-ID: 178725  Cd Length: 421  Bit Score: 61.03  E-value: 4.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649197 133 IDMLDRLLRAIYMPQNFYCIHVDRKA---EESFLAA---VQGIASCFDNVFVASQLESVVYASWSRVKADLNCMKDLYRM 206
Cdd:PLN03183   91 LEKLWRTLRALYHPRNQYVVHLDLESpaeERLELASrveNDPMFSKVGNVYMITKANLVTYRGPTMVANTLHACAILLKR 170
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649197 207 NANWKYLINLCGMDFPIKTNLEIvrkLKSFTG----ENSLETEKMPPNKEERWKKRYTVVDG--KLTNTGVVKAQP---- 276
Cdd:PLN03183  171 SKDWDWFINLSASDYPLVTQDDL---IHTFSTldrnLNFIEHTSQLGWKEEKRAMPLIIDPGlySTNKSDIYWVTPrrsl 247
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958649197 277 PLKTPLFSGSAYFVVTREYVGYVL---ENKNIQKFMEWAQDTYSPDEFLWATIQRIPE 331
Cdd:PLN03183  248 PTAFKLFTGSAWMVLSRSFVEYCIwgwDNLPRTLLMYYTNFVSSPEGYFHTVICNVPE 305
 
Name Accession Description Interval E-value
Branch pfam02485
Core-2/I-Branching enzyme; This is a family of two different beta-1, ...
123-391 2.30e-74

Core-2/I-Branching enzyme; This is a family of two different beta-1,6-N-acetylglucosaminyltransferase enzymes, I-branching enzyme and core-2 branching enzyme. I-branching enzyme is responsible for the production of the blood group I-antigen during embryonic development. Core-2 branching enzyme forms crucial side-chain branches in O-glycans. This is a fmmily of glycosyl-transferases that are Type II membrane proteins that are found in the endoplasmic reticulum (ER) and Golgi apparatus.


Pssm-ID: 426795  Cd Length: 250  Bit Score: 232.94  E-value: 2.30e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649197 123 IAYSIVVHH-KIDMLDRLLRAIYMPQNFYCIHVDRKAEESFLAAVQGIASCFDNVFVASQLESVVYASWSRVKADLNCMK 201
Cdd:pfam02485   1 IAFMFLTYKgDLPLLELWLRFFYHPENLYSIYVDSKAPSYFRERVRALASCFFNVRVIPKSESVDWGGPSMVAAELRLLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649197 202 DLYRMNANWKYLINLCGMDFPIKTNLEIVRKLKSFTGENSL-ETEKMPPNKE-ERWKKRytVVDGKLTNTGVVKAQPPLK 279
Cdd:pfam02485  81 NLLLLDPSWDYFILLSESDIPLKTFDELYQYLSSLNGNNSFiDSFSDPGWKGrGRYKPR--ILDPMLPEIKKSKLFLPTA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649197 280 TPLFSGSAYFVVTREYVGYVLENKNIQKFMEWAQDTYSPDEFLWATIqripevpgsLPSSHKYDLSDMNAVARFVKWqyf 359
Cdd:pfam02485 159 FKWRKGSQWFVLSRAFAEYVVWDNLYYPLFKYYCDTCYPDEHYFPTL---------LCMSGEFPNTCANRTLTYVDW--- 226
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1958649197 360 egdvsNGAPYPPCSGVhvrsVCVFGVGDLSWM 391
Cdd:pfam02485 227 -----SRGGCHPKTYR----PCILGPEDLKRI 249
PLN03183 PLN03183
acetylglucosaminyltransferase family protein; Provisional
133-331 4.90e-10

acetylglucosaminyltransferase family protein; Provisional


Pssm-ID: 178725  Cd Length: 421  Bit Score: 61.03  E-value: 4.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649197 133 IDMLDRLLRAIYMPQNFYCIHVDRKA---EESFLAA---VQGIASCFDNVFVASQLESVVYASWSRVKADLNCMKDLYRM 206
Cdd:PLN03183   91 LEKLWRTLRALYHPRNQYVVHLDLESpaeERLELASrveNDPMFSKVGNVYMITKANLVTYRGPTMVANTLHACAILLKR 170
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958649197 207 NANWKYLINLCGMDFPIKTNLEIvrkLKSFTG----ENSLETEKMPPNKEERWKKRYTVVDG--KLTNTGVVKAQP---- 276
Cdd:PLN03183  171 SKDWDWFINLSASDYPLVTQDDL---IHTFSTldrnLNFIEHTSQLGWKEEKRAMPLIIDPGlySTNKSDIYWVTPrrsl 247
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958649197 277 PLKTPLFSGSAYFVVTREYVGYVL---ENKNIQKFMEWAQDTYSPDEFLWATIQRIPE 331
Cdd:PLN03183  248 PTAFKLFTGSAWMVLSRSFVEYCIwgwDNLPRTLLMYYTNFVSSPEGYFHTVICNVPE 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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