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transformation/transcription domain-associated protein isoform X5 [Rattus norvegicus]
Protein Classification
transformation/transcription domain-associated protein ( domain architecture ID 13414838 )
transformation/transcription domain-associated protein (TRRAP) contains a pseudokinase domain, belonging to the phosphoinositide 3-kinase-related protein kinase (PIKK) family, that lacks the conserved residues necessary for ATP-binding and catalytic activity; it is a common component of many histone acetyltransferase (HAT) complexes, and is responsible for the recruitment of these complexes to chromatin during transcription, replication, and DNA repair
List of domain hits
Name
Accession
Description
Interval
E-value
Tra1_ring
pfam20206 Tra1 HEAT repeat ring region; This entry represents part of the Tra1 protein composed of alpha ...
894-2689
0e+00
Tra1 HEAT repeat ring region; This entry represents part of the Tra1 protein composed of alpha solenoid repeats that form a ring region.
Pssm-ID: 466357
Cd Length: 1678
Bit Score: 1705.21
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 894 R V LGK F GG S NR KM LKE SQR L H Y V - VTEVQGPSITV EF s DCKASLQ LP MEK A IET A LDC L K S ANTE P Y YR R QA W E VIRCF L 972
Cdd:pfam20206 1 R I LGK L GG R NR RF LKE PPK L E Y R d AGDEASLTVEL EF - GAPSDQT LP LDP A VDL A KRT L R S STSL P H YR K QA F E LLKSA L 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 973 VAMMSLE D NKH --- A LY Q LLAH P NFTE K T ------- IPSVIISHRY - KA QDTPARKT F E QAL T G A F MS A V IK D LR PS ALP 1041
Cdd:pfam20206 80 ALLLDSD D SPD dll A RL Q AAIQ P LLEV K I eseapsd LSNLNTDDSA a KA KAEEQEEL F K QAL K G L F FA A S IK E LR AE ALP 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1042 F VAS L I RH Y T MVAV A QQC GPF LLPCYQV gsqpstamfhs EEN G S kg M DPLV L IDAI AICMAY E E KEL CKI GE VA L AV I F D 1121
Cdd:pfam20206 160 F LKG L L RH F T LLEL A EEI GPF KESRRRF ----------- NLE G P -- L DPLV F IDAI VESLSS E S KEL RDA GE SV L KL I L D 226
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1122 VASII LGSKE RAC QL -- PLF S Y IVE R L C AC CYE Q AWY A KLGG VVS I KF L M ER -- L P L T WVL QN Q QT F LK ALLFV MM D LTG 1197
Cdd:pfam20206 227 TLVTL LGSKE VVD QL ne PLF H Y LAS R F C HL CYE E AWY R KLGG CLG I RI L L ER ld L G L K WVL DH Q LE F VR ALLFV LK D MPP 306
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1198 EV SN G A V AM AK T TL EQL L MR C A TP L K DEERAE E IVVA Q EKSFHHVTHD LV R E VT S P N ST VR KQ A MHS L QV LA QV TG KS VT 1277
Cdd:pfam20206 307 EV PS G N V DD AK D TL LFI L KV C N TP P K STPKTT E GTAK Q RSKLNTLVGL LV S E LS S S N EI VR ET A QKA L EL LA EL TG IP VT 386
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1278 VIM EP H KE V L q DMVPPK K H L l R HQ P ANA QIG LMEGN TFC TT L Q P R L FTMDLNV V E hkv FYT E L L N L CE AED S AL TKL - P C 1356
Cdd:pfam20206 387 ELL EP V KE R L - LQPIFT K P L - R AL P FPM QIG HIDAI TFC LS L R P P L LEFNEEL V R --- LLH E A L A L AD AED A AL VGR n P Q 461
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1357 YK S L PS L VP LR I A ALNA L A A CNYL P -------- QS R EK II AAL FK A L N S TNS E LQE A GEACMRKF L - EGATIEV D QIH T H 1427
Cdd:pfam20206 462 YK N L TQ L IQ LR V A CIRL L S A AMAC P dflapkqv NT R NR II SVF FK S L Y S RSP E VVD A AHDGLKQV L a QQQKLPK D LLQ T G 541
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1428 M RP L LM M L G D YRS LT LNVVNR L TSVTR L FP N S F NDKFCDQMMQ HLRKW ME vvvithkggqrsdg N E S L S E C grc SL S P F c 1507
Cdd:pfam20206 542 L RP I LM N L S D HKR LT VAGLEG L ARLLE L LT N Y F KVEIGEKLLD HLRKW AD -------------- P E M L Q E A --- SL K P L - 603
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1508 qfepav E GV EE M KI CS AI I N L FHL I P A A PQTLVKP L LEV V MKT E RAMLIEAG SPFREPL I K F L T R H P SQT VE L F M me AT L 1587
Cdd:pfam20206 604 ------ E EN EE V KI AA AI L N I FHL L P P A ASKFLED L VKL V IQL E AVLRRYVS SPFREPL A K Y L N R Y P EEA VE F F L -- ER L 675
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1588 N DP QW SR M F MSF LK HK DA R PLR DVLAAN P N R FIT L LLPGGAQ TA vrpgspsts NMRLD L QF Q AIK I ISII VK NDDA WL AN 1667
Cdd:pfam20206 676 S DP RY SR L F RDI LK SP DA E PLR AEVSSK P S R VSL L NIKLFLE TA --------- DSKTA L RY Q GLL I VRTL VK LNPN WL PS 746
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1668 QHSLVSQ L RRV W V S ETFQE R HRK E NMAATN -- WK E P KLL AFC LL N Y CKR N YG DI E LLF Q LL RA FT GRFLCNMT FL KEYME 1745
Cdd:pfam20206 747 NNDVLQA L LQL W R S LHRLQ R LGN E DSLIHF qq LR E S KLL LKI LL Q Y LRQ N PD DI D LLF D LL EI FT LPTVTDFS FL RDFLY 826
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1746 EE IPKN YS IA QKRA LFF RF V E - F N DP NFGDE LK A K V L Q H IL NP AFLY SFE K GE G - E Q L L gppnpegd NPES I TS v FIT K V 1823
Cdd:pfam20206 827 EE VALK YS VE QKRA ILL RF L E m F P DP TTSQD LK V K A L R H LI NP ILAA SFE R GE S k E E L V -------- DADV I DQ - LHA K I 897
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1824 LD P EKQ A DML ----- D S LRI Y LLQ YA TLLVE H A PHH I HD N N K N rnsklrr L MT FAW PC L LS kac V DP AC K YSGHL L L A HI 1898
Cdd:pfam20206 898 WK P LQL A GDD atfsd D G LRI E LLQ LS TLLVE Y A SEL I GE N R K D ------- L IK FAW NF L KL --- D DP TV K QAAYV L I A RF 967
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1899 I AK F AIHK KIVLQV FHS LLKAH AM E A RA I VRQA MA IL T PA V P A R M -- ED G HQMLTH WT RK I I VEEGH TV PQLVHI LH LIV 1976
Cdd:pfam20206 968 I EA F DTPP KIVLQV YVA LLKAH QP E G RA L VRQA LD IL A PA L P K R L pe NP G YPTWVK WT KR I L VEEGH SI PQLVHI YQ LIV 1047
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1977 Q H FKVY YP V R HHL V Q HMV SAM Q R LG FT P SV T I E Q R R LAVDL S E VV I K WE LQ R IKDQQPDSDMDPN SGG E gvnsvsi K RGL 2056
Cdd:pfam20206 1048 R H PDLF YP N R ELF V P HMV TSL Q K LG LP P NA T T E T R K LAVDL A E LI I R WE RR R SESMDVSESSNEE SGG D ------- K QTV 1120
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2057 SV DS AQEV K R F RAATGAISAV fgrsqsl P GAD SLLAK PI DKQHTD TVVNFLIR V AC qvndn T N T AG S PGEV LS R R CVN LL 2136
Cdd:pfam20206 1121 PL DS SSSP K S F ASSSASADPT ------- M GAD DSSNY PI PLSLRE TVVNFLIR F AC ----- T S T ED S SSKG LS A R ALE LL 1188
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2137 K TA L R PD M W CKSEL KL QW F D K L L MTV E q PNQVNYGN IC TG LE V LN FL L T V LQSPA I L S SFKP LQ RGIAA C MTCG N T K VLR 2216
Cdd:pfam20206 1189 K DL L S PD L W PDVSI KL SF F E K V L AQT E - VSENSIPQ IC NA LE I LN IV L E V KPNAW I I S NLSQ LQ KLLEK C LKSD N P K IQE 1267
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2217 A VHSL L S R LMSIF P TEPST S SV A sky EE LECL Y AAVGKV I Y EGL TNYEKA tsanps Q L F GTL MI L KSACCNN P S YID RL I 2296
Cdd:pfam20206 1268 A LRPI L K R ILEAL P VSVEG S ED A --- EE VSSF Y KFIETI I T EGL SSLTNT ------ G L L GTL SL L SAWAKHR P D YID PF I 1338
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2297 SVF M RS LQK M V R EHL -- N P Q A AS G S TEATAAG -- AS EL VMLS L D L V K T R LAVMS m E M R KN F IQ t I L TS LIEKS P D AKI LR 2372
Cdd:pfam20206 1339 PSL M KV LQK L V K EHL aa N S Q D AS S S SASPPPF es TA EL LIKT L E L L K L R VSHLG - E Q R RW F LS - A L VQ LIEKS N D VEL LR 1416
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2373 AVVKI V E EW V K nnsp MAANQT PT LR EK SI LLVKMM TYI ekr F PE D LE L N A Q FLDL VNYV Y R D E AL SG SELT AK LEPAFL S 2452
Cdd:pfam20206 1417 TILDM V R EW I K ---- EQTEGF PT IK EK AG LLVKMM SFE --- F RG D AA L S A D FLDL ILDI Y E D P AL AR SELT VR LEPAFL M 1489
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2453 GLR CAQ P L IR A KFF EV FDNS MK R RVY ERLLY VTCS QNWE AM G S H F WIKQ CIE LLL AVCE K STAIGT S CQG A ML PS I T NVI 2532
Cdd:pfam20206 1490 GLR SSD P K IR K KFF AI FDNS LS R SLA ERLLY ILGV QNWE SL G D H Y WIKQ ALD LLL GSVD K DNPLSL S ESS A SI PS L T ALE 1569
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2533 nladshdraafamvthvkqeprerenseskeedveidielapgdqtst PKT KE L S EKDIGNQ L HM L TNR H DK FLD T LR E V 2612
Cdd:pfam20206 1570 ------------------------------------------------ EAD KE E S YEMEDDE L DK L LSG H RA FLD E LR S V 1601
1770 1780 1790 1800 1810 1820 1830
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958668068 2613 KT G A LL SAFV QL C H ISTT L AE K T WV Q LFP RL W KI LS D R Q Q HA L AGE I S P F L CSGS H QV Q R D CQ P SALNCFV E AMSQ C 2689
Cdd:pfam20206 1602 TL G D LL DPLR QL L H QDSN L TH K L WV S LFP AA W SA LS R R E Q ED L TKA I V P L L SKDY H SK Q A D KR P NVIQTLL E GVAR C 1678
Tra1_central
pfam20175 Tra1 HEAT repeat central region; This entry represents part of the Tra1 protein composed of ...
276-882
0e+00
Tra1 HEAT repeat central region; This entry represents part of the Tra1 protein composed of alpha solenoid repeats that forms the central region. This is named as central due to its position relative to the ring region.
Pssm-ID: 466326
Cd Length: 593
Bit Score: 739.06
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 276 LY A DFIAAQ I KTLSFLAY II R IYQ E LVTK Y SQQMVKGMLQ LL SN CP A E TAHL RKELL I A AK HIL T TE L R NQ F I P CM D K L F 355
Cdd:pfam20175 1 LY G DFIAAQ V KTLSFLAY LL R GFA E QLRP Y QDKLPEIVVR LL QD CP P E ASST RKELL V A TR HIL S TE F R SG F V P HI D L L L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 356 DE SI LIG S G Y T AR ETLRPLAYS T LADL V HHVR QH L PLSD LS LA V QLFA KN ID D ES LP S SIQTMS C KLLLNLVD C I RS K SE 435
Cdd:pfam20175 81 DE KV LIG T G V T SY ETLRPLAYS M LADL I HHVR AE L SIEQ LS KV V SIYS KN LH D PT LP P SIQTMS A KLLLNLVD S I VK K DD 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 436 QESGNG RD V L M R M LE V FV L K FHTIA RY Q --- L SAIF KK CKPQS E LGA A EAALPGVPT A PAAPGPAPSPAPVPAP pppppp 512
Cdd:pfam20175 161 KDPQEA RD L L V R I LE T FV E K LKSLN RY Y ppl L KQHR KK KSEKE E KTS A DVDADEDRP A DIDTVEYLAIERAKPI ------ 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 513 apapatpvtpapvppfek Q G EKDKEDKQTFQVT D C R S L V KTL VC G V KTI T WG ITS C KAPGEA Q FI P NKQLQ ------ P K E 586
Cdd:pfam20175 235 ------------------ E G IQFPSPSPVDPLK D A R F L F KTL LH G L KTI I WG LRN C QPTPPQ Q NA P SGWNS varglp P E E 296
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 587 TQ I Y I K L V K YAMQAL D I Y Q vq I AGNGQ T YIRVANCQTVRM KEEKEVLE H FA GV FT MMN P L TF K E I F QTTV P YMV ERI SK N 666
Cdd:pfam20175 297 VD I F I R L F K EGVKCF D L Y S -- I NKDPP T TASSSSISRTSS KEEKEVLE L FA SI FT ILD P A TF Q E V F TSRM P FLF ERI LE N 374
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 667 Y AL QIVANS FL A N PTT S AL FA T IL VEY L LE RL PEM G S - NVEL S NLY L K LFKL V F GS V S LF AA ENE QM L K PHL H K IVNS S M 745
Cdd:pfam20175 375 P AL LAIPQF FL S N DSV S PR FA S IL LRF L VD RL EDL G A a DKKK S SVL L R LFKL A F MA V T LF PE ENE AV L Q PHL P K LILT S L 454
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 746 E LA QT AKEP Y NYFLLLRALFRSIGGG SHD LLY Q E F LPLLP N LL Q GLN M L Q S GL H KQH M K DLFVELCLTVPVRLS S LLPYL 825
Cdd:pfam20175 455 K LA LK AKEP L NYFLLLRALFRSIGGG RFE LLY K E V LPLLP V LL E GLN R L L S SA H RPS M R DLFVELCLTVPVRLS V LLPYL 534
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*..
gi 1958668068 826 PM LM D PLV S ALN G S QT LVSQGLRTLELCVDNL Q P D FL YDHI QPV RAE LMQALW RT LR 882
Cdd:pfam20175 535 SL LM K PLV L ALN S S PE LVSQGLRTLELCVDNL T P E FL DPIM QPV IDD LMQALW KH LR 591
PIKK_TRRAP
cd05163 Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein; TRRAP belongs ...
3521-3834
1.04e-115
Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein; TRRAP belongs to the the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. It contains a FATC (FRAP, ATM and TRRAP, C-terminal) domain and has a large molecular weight. Unlike most PIKK proteins, however, it contains an inactive PI3K-like pseudokinase domain, which lacks the conserved residues necessary for ATP binding and catalytic activity. TRRAP also contains many motifs that may be critical for protein-protein interactions. TRRAP is a common component of many histone acetyltransferase (HAT) complexes, and is responsible for the recruitment of these complexes to chromatin during transcription, replication, and DNA repair. TRRAP also exists in non-HAT complexes such as the p400 and MRN complexes, which are implicated in ATP-dependent remodeling and DNA repair, respectively. The TRRAP pseudokinase domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and RIO kinases.
Pssm-ID: 270707
Cd Length: 252
Bit Score: 367.62
E-value: 1.04e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3521 IARF M PRVEIV QK H N T AA RRL Y IRGH N G KI YP Y LV MNDACLT e SRREERV L QL L RLLN PC LE KR KET TK R H L F F T VP R VV 3600
Cdd:cd05163 1 IARF L PRVEIV RR H G T CY RRL T IRGH D G SK YP F LV QTPSARH - SRREERV M QL F RLLN RV LE RK KET RR R N L Q F H VP I VV 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3601 AV SPQ M RLVED N PS SL SL VE IY K qrcakkgiehdnpisryydrlatvqargtqashqipalgwedfvqgcverqeaavla 3680
Cdd:cd05163 80 PL SPQ V RLVED D PS YI SL QD IY E --------------------------------------------------------- 102
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3681 ppqv LRD IL K E V QS N MVP RSM L KEWA L H T F P NAT D Y W T FRK M FT I QLAL IG F AEF VL H L NRLN P EMLQ I AQD TG KLNVAY 3760
Cdd:cd05163 103 ---- KLE IL N E I QS K MVP ETI L SNYF L R T M P SPS D L W L FRK Q FT L QLAL SS F MTY VL S L GNRT P HRIL I SRS TG NVFMTD 178
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958668068 3761 F RFD IN DATGD LD A N R PVPFRLTPNI SE F LTT IGV S G P LT A SM I A VS R CFAQ P NFKVDGI L KTVL RDE I I A WHK 3834
Cdd:cd05163 179 F LPS IN SQGPL LD N N E PVPFRLTPNI QH F IGP IGV E G L LT S SM M A IA R ALTE P EYDLEQY L SLFV RDE L I S WHK 252
FAT
pfam02259 FAT domain; The FAT domain is named after FRAP, ATM and TRRAP.
2858-3211
2.83e-77
FAT domain; The FAT domain is named after FRAP, ATM and TRRAP.
Pssm-ID: 396714 [Multi-domain]
Cd Length: 342
Bit Score: 261.13
E-value: 2.83e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2858 L VL E C AWR VSN W TA M K E A L VQVEVSC P KE mawrv NMYRGY LA ICH pee Q Q LSFI ER LV E M A SS L AIR E WRR L PHVVSHVH 2937
Cdd:pfam02259 3 L AA E A AWR LGQ W DL M R E Y L SLMKKDS P DK ----- AFFEAI LA LHR --- N Q FDEA ER YI E K A RQ L LDT E LSA L SGESYNRA 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2938 T PLL QAA QQ II EL Q E AA Q INAG L Q ptnlgrn N S LHDM K TVVK TWRNRLP IVS DD LSH W SSVFMW R QHHYQ gkptwsgmhs 3017
Cdd:pfam02259 75 Y PLL VRL QQ LA EL E E II Q YKQK L G ------- Q S SEEL K SLLQ TWRNRLP GCQ DD VEI W QDILTV R SLVLS ---------- 137
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3018 ssivtayensshhd P SSNNAML G V H as A SAIIQYGKI ARK Q G LVNV A LDI L SRI ------------------ HTI PT VPI 3079
Cdd:pfam02259 138 -------------- P IEDVYLG G Y H -- A EMWLKFANL ARK S G RFSL A EKA L LKL lgedpeewlpevvyayak YLW PT GEQ 201
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3080 VDCFQ K I R QQVK CYLQ lagvm GKN E CMQ GLEVI ES TNL KY FT KEM t A EF Y A LKG MFL A QINK ------ SEE ANK A FSA A V 3153
Cdd:pfam02259 202 QEALL K L R EFLS CYLQ ----- KNG E LLS GLEVI NP TNL EE FT ELL - A RC Y L LKG KWQ A ALGQ nwaeek SEE ILQ A YLL A T 275
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958668068 3154 Q MHDVLV KAW AM W GDYLESIFV KE R Q L ---------- HLG V S A ITC YL HACRHQN E s K S RKYLAKV L W 3211
Cdd:pfam02259 276 Q FDPSWY KAW HT W ALFNFEVLR KE E Q G keeegpedls RYV V P A VEG YL RSLSLSS E - N S LQDTLRL L T 342
FATC
pfam02260 FATC domain; The FATC domain is named after FRAP, ATM, TRRAP C-terminal. The solution ...
3883-3910
9.96e-04
FATC domain; The FATC domain is named after FRAP, ATM, TRRAP C-terminal. The solution structure of the FATC domain suggests it plays a role in redox-dependent structural and cellular stability.
Pssm-ID: 460514 [Multi-domain]
Cd Length: 32
Bit Score: 38.90
E-value: 9.96e-04
10 20
....*....|....*....|....*...
gi 1958668068 3883 E SK V NT L VAA A NSLD NL CR M DPA W H PW L 3910
Cdd:pfam02260 5 E GQ V DE L IQE A TDPE NL AQ M YIG W C PW W 32
Name
Accession
Description
Interval
E-value
Tra1_ring
pfam20206 Tra1 HEAT repeat ring region; This entry represents part of the Tra1 protein composed of alpha ...
894-2689
0e+00
Tra1 HEAT repeat ring region; This entry represents part of the Tra1 protein composed of alpha solenoid repeats that form a ring region.
Pssm-ID: 466357
Cd Length: 1678
Bit Score: 1705.21
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 894 R V LGK F GG S NR KM LKE SQR L H Y V - VTEVQGPSITV EF s DCKASLQ LP MEK A IET A LDC L K S ANTE P Y YR R QA W E VIRCF L 972
Cdd:pfam20206 1 R I LGK L GG R NR RF LKE PPK L E Y R d AGDEASLTVEL EF - GAPSDQT LP LDP A VDL A KRT L R S STSL P H YR K QA F E LLKSA L 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 973 VAMMSLE D NKH --- A LY Q LLAH P NFTE K T ------- IPSVIISHRY - KA QDTPARKT F E QAL T G A F MS A V IK D LR PS ALP 1041
Cdd:pfam20206 80 ALLLDSD D SPD dll A RL Q AAIQ P LLEV K I eseapsd LSNLNTDDSA a KA KAEEQEEL F K QAL K G L F FA A S IK E LR AE ALP 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1042 F VAS L I RH Y T MVAV A QQC GPF LLPCYQV gsqpstamfhs EEN G S kg M DPLV L IDAI AICMAY E E KEL CKI GE VA L AV I F D 1121
Cdd:pfam20206 160 F LKG L L RH F T LLEL A EEI GPF KESRRRF ----------- NLE G P -- L DPLV F IDAI VESLSS E S KEL RDA GE SV L KL I L D 226
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1122 VASII LGSKE RAC QL -- PLF S Y IVE R L C AC CYE Q AWY A KLGG VVS I KF L M ER -- L P L T WVL QN Q QT F LK ALLFV MM D LTG 1197
Cdd:pfam20206 227 TLVTL LGSKE VVD QL ne PLF H Y LAS R F C HL CYE E AWY R KLGG CLG I RI L L ER ld L G L K WVL DH Q LE F VR ALLFV LK D MPP 306
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1198 EV SN G A V AM AK T TL EQL L MR C A TP L K DEERAE E IVVA Q EKSFHHVTHD LV R E VT S P N ST VR KQ A MHS L QV LA QV TG KS VT 1277
Cdd:pfam20206 307 EV PS G N V DD AK D TL LFI L KV C N TP P K STPKTT E GTAK Q RSKLNTLVGL LV S E LS S S N EI VR ET A QKA L EL LA EL TG IP VT 386
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1278 VIM EP H KE V L q DMVPPK K H L l R HQ P ANA QIG LMEGN TFC TT L Q P R L FTMDLNV V E hkv FYT E L L N L CE AED S AL TKL - P C 1356
Cdd:pfam20206 387 ELL EP V KE R L - LQPIFT K P L - R AL P FPM QIG HIDAI TFC LS L R P P L LEFNEEL V R --- LLH E A L A L AD AED A AL VGR n P Q 461
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1357 YK S L PS L VP LR I A ALNA L A A CNYL P -------- QS R EK II AAL FK A L N S TNS E LQE A GEACMRKF L - EGATIEV D QIH T H 1427
Cdd:pfam20206 462 YK N L TQ L IQ LR V A CIRL L S A AMAC P dflapkqv NT R NR II SVF FK S L Y S RSP E VVD A AHDGLKQV L a QQQKLPK D LLQ T G 541
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1428 M RP L LM M L G D YRS LT LNVVNR L TSVTR L FP N S F NDKFCDQMMQ HLRKW ME vvvithkggqrsdg N E S L S E C grc SL S P F c 1507
Cdd:pfam20206 542 L RP I LM N L S D HKR LT VAGLEG L ARLLE L LT N Y F KVEIGEKLLD HLRKW AD -------------- P E M L Q E A --- SL K P L - 603
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1508 qfepav E GV EE M KI CS AI I N L FHL I P A A PQTLVKP L LEV V MKT E RAMLIEAG SPFREPL I K F L T R H P SQT VE L F M me AT L 1587
Cdd:pfam20206 604 ------ E EN EE V KI AA AI L N I FHL L P P A ASKFLED L VKL V IQL E AVLRRYVS SPFREPL A K Y L N R Y P EEA VE F F L -- ER L 675
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1588 N DP QW SR M F MSF LK HK DA R PLR DVLAAN P N R FIT L LLPGGAQ TA vrpgspsts NMRLD L QF Q AIK I ISII VK NDDA WL AN 1667
Cdd:pfam20206 676 S DP RY SR L F RDI LK SP DA E PLR AEVSSK P S R VSL L NIKLFLE TA --------- DSKTA L RY Q GLL I VRTL VK LNPN WL PS 746
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1668 QHSLVSQ L RRV W V S ETFQE R HRK E NMAATN -- WK E P KLL AFC LL N Y CKR N YG DI E LLF Q LL RA FT GRFLCNMT FL KEYME 1745
Cdd:pfam20206 747 NNDVLQA L LQL W R S LHRLQ R LGN E DSLIHF qq LR E S KLL LKI LL Q Y LRQ N PD DI D LLF D LL EI FT LPTVTDFS FL RDFLY 826
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1746 EE IPKN YS IA QKRA LFF RF V E - F N DP NFGDE LK A K V L Q H IL NP AFLY SFE K GE G - E Q L L gppnpegd NPES I TS v FIT K V 1823
Cdd:pfam20206 827 EE VALK YS VE QKRA ILL RF L E m F P DP TTSQD LK V K A L R H LI NP ILAA SFE R GE S k E E L V -------- DADV I DQ - LHA K I 897
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1824 LD P EKQ A DML ----- D S LRI Y LLQ YA TLLVE H A PHH I HD N N K N rnsklrr L MT FAW PC L LS kac V DP AC K YSGHL L L A HI 1898
Cdd:pfam20206 898 WK P LQL A GDD atfsd D G LRI E LLQ LS TLLVE Y A SEL I GE N R K D ------- L IK FAW NF L KL --- D DP TV K QAAYV L I A RF 967
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1899 I AK F AIHK KIVLQV FHS LLKAH AM E A RA I VRQA MA IL T PA V P A R M -- ED G HQMLTH WT RK I I VEEGH TV PQLVHI LH LIV 1976
Cdd:pfam20206 968 I EA F DTPP KIVLQV YVA LLKAH QP E G RA L VRQA LD IL A PA L P K R L pe NP G YPTWVK WT KR I L VEEGH SI PQLVHI YQ LIV 1047
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1977 Q H FKVY YP V R HHL V Q HMV SAM Q R LG FT P SV T I E Q R R LAVDL S E VV I K WE LQ R IKDQQPDSDMDPN SGG E gvnsvsi K RGL 2056
Cdd:pfam20206 1048 R H PDLF YP N R ELF V P HMV TSL Q K LG LP P NA T T E T R K LAVDL A E LI I R WE RR R SESMDVSESSNEE SGG D ------- K QTV 1120
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2057 SV DS AQEV K R F RAATGAISAV fgrsqsl P GAD SLLAK PI DKQHTD TVVNFLIR V AC qvndn T N T AG S PGEV LS R R CVN LL 2136
Cdd:pfam20206 1121 PL DS SSSP K S F ASSSASADPT ------- M GAD DSSNY PI PLSLRE TVVNFLIR F AC ----- T S T ED S SSKG LS A R ALE LL 1188
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2137 K TA L R PD M W CKSEL KL QW F D K L L MTV E q PNQVNYGN IC TG LE V LN FL L T V LQSPA I L S SFKP LQ RGIAA C MTCG N T K VLR 2216
Cdd:pfam20206 1189 K DL L S PD L W PDVSI KL SF F E K V L AQT E - VSENSIPQ IC NA LE I LN IV L E V KPNAW I I S NLSQ LQ KLLEK C LKSD N P K IQE 1267
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2217 A VHSL L S R LMSIF P TEPST S SV A sky EE LECL Y AAVGKV I Y EGL TNYEKA tsanps Q L F GTL MI L KSACCNN P S YID RL I 2296
Cdd:pfam20206 1268 A LRPI L K R ILEAL P VSVEG S ED A --- EE VSSF Y KFIETI I T EGL SSLTNT ------ G L L GTL SL L SAWAKHR P D YID PF I 1338
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2297 SVF M RS LQK M V R EHL -- N P Q A AS G S TEATAAG -- AS EL VMLS L D L V K T R LAVMS m E M R KN F IQ t I L TS LIEKS P D AKI LR 2372
Cdd:pfam20206 1339 PSL M KV LQK L V K EHL aa N S Q D AS S S SASPPPF es TA EL LIKT L E L L K L R VSHLG - E Q R RW F LS - A L VQ LIEKS N D VEL LR 1416
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2373 AVVKI V E EW V K nnsp MAANQT PT LR EK SI LLVKMM TYI ekr F PE D LE L N A Q FLDL VNYV Y R D E AL SG SELT AK LEPAFL S 2452
Cdd:pfam20206 1417 TILDM V R EW I K ---- EQTEGF PT IK EK AG LLVKMM SFE --- F RG D AA L S A D FLDL ILDI Y E D P AL AR SELT VR LEPAFL M 1489
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2453 GLR CAQ P L IR A KFF EV FDNS MK R RVY ERLLY VTCS QNWE AM G S H F WIKQ CIE LLL AVCE K STAIGT S CQG A ML PS I T NVI 2532
Cdd:pfam20206 1490 GLR SSD P K IR K KFF AI FDNS LS R SLA ERLLY ILGV QNWE SL G D H Y WIKQ ALD LLL GSVD K DNPLSL S ESS A SI PS L T ALE 1569
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2533 nladshdraafamvthvkqeprerenseskeedveidielapgdqtst PKT KE L S EKDIGNQ L HM L TNR H DK FLD T LR E V 2612
Cdd:pfam20206 1570 ------------------------------------------------ EAD KE E S YEMEDDE L DK L LSG H RA FLD E LR S V 1601
1770 1780 1790 1800 1810 1820 1830
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958668068 2613 KT G A LL SAFV QL C H ISTT L AE K T WV Q LFP RL W KI LS D R Q Q HA L AGE I S P F L CSGS H QV Q R D CQ P SALNCFV E AMSQ C 2689
Cdd:pfam20206 1602 TL G D LL DPLR QL L H QDSN L TH K L WV S LFP AA W SA LS R R E Q ED L TKA I V P L L SKDY H SK Q A D KR P NVIQTLL E GVAR C 1678
Tra1_central
pfam20175 Tra1 HEAT repeat central region; This entry represents part of the Tra1 protein composed of ...
276-882
0e+00
Tra1 HEAT repeat central region; This entry represents part of the Tra1 protein composed of alpha solenoid repeats that forms the central region. This is named as central due to its position relative to the ring region.
Pssm-ID: 466326
Cd Length: 593
Bit Score: 739.06
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 276 LY A DFIAAQ I KTLSFLAY II R IYQ E LVTK Y SQQMVKGMLQ LL SN CP A E TAHL RKELL I A AK HIL T TE L R NQ F I P CM D K L F 355
Cdd:pfam20175 1 LY G DFIAAQ V KTLSFLAY LL R GFA E QLRP Y QDKLPEIVVR LL QD CP P E ASST RKELL V A TR HIL S TE F R SG F V P HI D L L L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 356 DE SI LIG S G Y T AR ETLRPLAYS T LADL V HHVR QH L PLSD LS LA V QLFA KN ID D ES LP S SIQTMS C KLLLNLVD C I RS K SE 435
Cdd:pfam20175 81 DE KV LIG T G V T SY ETLRPLAYS M LADL I HHVR AE L SIEQ LS KV V SIYS KN LH D PT LP P SIQTMS A KLLLNLVD S I VK K DD 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 436 QESGNG RD V L M R M LE V FV L K FHTIA RY Q --- L SAIF KK CKPQS E LGA A EAALPGVPT A PAAPGPAPSPAPVPAP pppppp 512
Cdd:pfam20175 161 KDPQEA RD L L V R I LE T FV E K LKSLN RY Y ppl L KQHR KK KSEKE E KTS A DVDADEDRP A DIDTVEYLAIERAKPI ------ 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 513 apapatpvtpapvppfek Q G EKDKEDKQTFQVT D C R S L V KTL VC G V KTI T WG ITS C KAPGEA Q FI P NKQLQ ------ P K E 586
Cdd:pfam20175 235 ------------------ E G IQFPSPSPVDPLK D A R F L F KTL LH G L KTI I WG LRN C QPTPPQ Q NA P SGWNS varglp P E E 296
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 587 TQ I Y I K L V K YAMQAL D I Y Q vq I AGNGQ T YIRVANCQTVRM KEEKEVLE H FA GV FT MMN P L TF K E I F QTTV P YMV ERI SK N 666
Cdd:pfam20175 297 VD I F I R L F K EGVKCF D L Y S -- I NKDPP T TASSSSISRTSS KEEKEVLE L FA SI FT ILD P A TF Q E V F TSRM P FLF ERI LE N 374
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 667 Y AL QIVANS FL A N PTT S AL FA T IL VEY L LE RL PEM G S - NVEL S NLY L K LFKL V F GS V S LF AA ENE QM L K PHL H K IVNS S M 745
Cdd:pfam20175 375 P AL LAIPQF FL S N DSV S PR FA S IL LRF L VD RL EDL G A a DKKK S SVL L R LFKL A F MA V T LF PE ENE AV L Q PHL P K LILT S L 454
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 746 E LA QT AKEP Y NYFLLLRALFRSIGGG SHD LLY Q E F LPLLP N LL Q GLN M L Q S GL H KQH M K DLFVELCLTVPVRLS S LLPYL 825
Cdd:pfam20175 455 K LA LK AKEP L NYFLLLRALFRSIGGG RFE LLY K E V LPLLP V LL E GLN R L L S SA H RPS M R DLFVELCLTVPVRLS V LLPYL 534
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*..
gi 1958668068 826 PM LM D PLV S ALN G S QT LVSQGLRTLELCVDNL Q P D FL YDHI QPV RAE LMQALW RT LR 882
Cdd:pfam20175 535 SL LM K PLV L ALN S S PE LVSQGLRTLELCVDNL T P E FL DPIM QPV IDD LMQALW KH LR 591
PIKK_TRRAP
cd05163 Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein; TRRAP belongs ...
3521-3834
1.04e-115
Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein; TRRAP belongs to the the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. It contains a FATC (FRAP, ATM and TRRAP, C-terminal) domain and has a large molecular weight. Unlike most PIKK proteins, however, it contains an inactive PI3K-like pseudokinase domain, which lacks the conserved residues necessary for ATP binding and catalytic activity. TRRAP also contains many motifs that may be critical for protein-protein interactions. TRRAP is a common component of many histone acetyltransferase (HAT) complexes, and is responsible for the recruitment of these complexes to chromatin during transcription, replication, and DNA repair. TRRAP also exists in non-HAT complexes such as the p400 and MRN complexes, which are implicated in ATP-dependent remodeling and DNA repair, respectively. The TRRAP pseudokinase domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and RIO kinases.
Pssm-ID: 270707
Cd Length: 252
Bit Score: 367.62
E-value: 1.04e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3521 IARF M PRVEIV QK H N T AA RRL Y IRGH N G KI YP Y LV MNDACLT e SRREERV L QL L RLLN PC LE KR KET TK R H L F F T VP R VV 3600
Cdd:cd05163 1 IARF L PRVEIV RR H G T CY RRL T IRGH D G SK YP F LV QTPSARH - SRREERV M QL F RLLN RV LE RK KET RR R N L Q F H VP I VV 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3601 AV SPQ M RLVED N PS SL SL VE IY K qrcakkgiehdnpisryydrlatvqargtqashqipalgwedfvqgcverqeaavla 3680
Cdd:cd05163 80 PL SPQ V RLVED D PS YI SL QD IY E --------------------------------------------------------- 102
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3681 ppqv LRD IL K E V QS N MVP RSM L KEWA L H T F P NAT D Y W T FRK M FT I QLAL IG F AEF VL H L NRLN P EMLQ I AQD TG KLNVAY 3760
Cdd:cd05163 103 ---- KLE IL N E I QS K MVP ETI L SNYF L R T M P SPS D L W L FRK Q FT L QLAL SS F MTY VL S L GNRT P HRIL I SRS TG NVFMTD 178
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958668068 3761 F RFD IN DATGD LD A N R PVPFRLTPNI SE F LTT IGV S G P LT A SM I A VS R CFAQ P NFKVDGI L KTVL RDE I I A WHK 3834
Cdd:cd05163 179 F LPS IN SQGPL LD N N E PVPFRLTPNI QH F IGP IGV E G L LT S SM M A IA R ALTE P EYDLEQY L SLFV RDE L I S WHK 252
FAT
pfam02259 FAT domain; The FAT domain is named after FRAP, ATM and TRRAP.
2858-3211
2.83e-77
FAT domain; The FAT domain is named after FRAP, ATM and TRRAP.
Pssm-ID: 396714 [Multi-domain]
Cd Length: 342
Bit Score: 261.13
E-value: 2.83e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2858 L VL E C AWR VSN W TA M K E A L VQVEVSC P KE mawrv NMYRGY LA ICH pee Q Q LSFI ER LV E M A SS L AIR E WRR L PHVVSHVH 2937
Cdd:pfam02259 3 L AA E A AWR LGQ W DL M R E Y L SLMKKDS P DK ----- AFFEAI LA LHR --- N Q FDEA ER YI E K A RQ L LDT E LSA L SGESYNRA 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2938 T PLL QAA QQ II EL Q E AA Q INAG L Q ptnlgrn N S LHDM K TVVK TWRNRLP IVS DD LSH W SSVFMW R QHHYQ gkptwsgmhs 3017
Cdd:pfam02259 75 Y PLL VRL QQ LA EL E E II Q YKQK L G ------- Q S SEEL K SLLQ TWRNRLP GCQ DD VEI W QDILTV R SLVLS ---------- 137
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3018 ssivtayensshhd P SSNNAML G V H as A SAIIQYGKI ARK Q G LVNV A LDI L SRI ------------------ HTI PT VPI 3079
Cdd:pfam02259 138 -------------- P IEDVYLG G Y H -- A EMWLKFANL ARK S G RFSL A EKA L LKL lgedpeewlpevvyayak YLW PT GEQ 201
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3080 VDCFQ K I R QQVK CYLQ lagvm GKN E CMQ GLEVI ES TNL KY FT KEM t A EF Y A LKG MFL A QINK ------ SEE ANK A FSA A V 3153
Cdd:pfam02259 202 QEALL K L R EFLS CYLQ ----- KNG E LLS GLEVI NP TNL EE FT ELL - A RC Y L LKG KWQ A ALGQ nwaeek SEE ILQ A YLL A T 275
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958668068 3154 Q MHDVLV KAW AM W GDYLESIFV KE R Q L ---------- HLG V S A ITC YL HACRHQN E s K S RKYLAKV L W 3211
Cdd:pfam02259 276 Q FDPSWY KAW HT W ALFNFEVLR KE E Q G keeegpedls RYV V P A VEG YL RSLSLSS E - N S LQDTLRL L T 342
TEL1
COG5032 Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms];
2552-3910
9.94e-68
Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms];
Pssm-ID: 227365 [Multi-domain]
Cd Length: 2105
Bit Score: 256.63
E-value: 9.94e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2552 E PRERENSES K EEDVEI d IELAPGDQ T STPKTKELSEKDIGNQLHMLTNRHDKF L DT L revktga LLSAFVQ LC HISTT L 2631
Cdd:COG5032 966 E CWLELMNSY K RLLIKS - LKSKLHLP T IPILILQMLLDSKNLTEFTEHQLKNLP L PS L ------- SIGFYES LC SFLAK L 1037
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2632 AEKTWVQL FP R L WKIL sdrqqhalage ISPF L CSGS H QV Q R D cqp SAL N CFVEAM S QCV pp IPMR P CVL KYL GKTHNLWF 2711
Cdd:COG5032 1038 LHDEELYF FP L L FVSS ----------- LETL L SVNY H IN Q L D --- LRP N ILKHFG S FVR -- FQLK P HLV KYL QRWYEALN 1101
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2712 R STLM L EHQAFEKGL S lpikpkqtaefyeqes I T PPQQEILDSLA ELYS L L Q E E DM WAG L WQK R c K FS ET AT A I AYEQ H G 2791
Cdd:COG5032 1102 R YFEL L SKGDRLFAI S ---------------- F T KLRNVDALGKL ELYS S L A E I DM FLS L HRR R - K LL ET LV A T AYEQ V G 1164
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2792 FFEQ AQ ES YE K A MD KA KKEHERSNA spaifp E Y QL W EDHW I R C SKE L NQWE A ltefgq SKGHINPY -- L V LE CA WR VSNW 2869
Cdd:COG5032 1165 EWYK AQ QL YE V A QR KA RSKEFPFSL ------ Q Y LY W HIND I D C ADK L QSVL A ------ ELSLVTGI se L L LE ES WR RALF 1232
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2870 TAM K EA L VQVEVSCPKE M AWRVNMYRGYLAICHPE E QQLSFI E -- RLVEMASS L AIRE W RR L PH VVS HVHT P L L Q aa QQI 2947
Cdd:COG5032 1233 SNI K DS L ESELEEIIDG M YKSNEDFGALMLLSLSA E LWDKIL E gr SSCSKSIK L SLNI W LD L SI VVS PKDE P E L F -- IKF 1310
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2948 I EL Q EA AQ I NAG L QPT N L grn NS L HDMKTVV K ---- T W R N RLP IVSDD L SHWSSVFM WRQ HH - YQGK P TWSGMH SS SI - V 3021
Cdd:COG5032 1311 V EL C EA SS I RSK L LEK N I --- QE L LEKLEEI K splg T L R D RLP PPWAL L DLKRLLAT WRQ NA f LRIN P ELLPLL SS LL n L 1387
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3022 TAYEN S SHHDPSSN namlgv HA SA SA I IQYGKI ARK qgl VNVALDI L SR I HTIPTVP I VDC F QKI R QQVK C Y L Q lagvmg 3101
Cdd:COG5032 1388 QSSSL S KQLVSRGS ------ SE SA IS I NSFASV ARK --- HFLPDNQ L KK I YQLSNIL I SEA F LLL R YLLL C R L G ------ 1452
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3102 KN E CMQ GL E V IES TNL KY F tkemtaefyalkgmflaqinkseeankafsaavqm H D VLVKAWAM WG -- DY L E SI FVKERQ 3179
Cdd:COG5032 1453 RR E LKA GL N V WNL TNL EL F ----------------------------------- S D IQESEFFE WG kn LK L L SI IPPIEE 1497
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3180 LH L GV s A IT CYL HA crh QNES K SRKYLAKVLW LLS FD D DKNTLADAVDKYCIGVPP I QW law IPQLL TC L VGSEGKLLLN 3259
Cdd:COG5032 1498 IF L SN - A LS CYL QV --- KDLL K KLNLFELLGS LLS AK D AAGSYYKNFHIFDLEISV I PF --- IPQLL SS L SLLDLNSAQS 1570
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3260 L I S QV G RVY PQA VY F PI R T lyltlkieq RERYKSD S GQQQPS S VG N Q S hsasdpgpi R ATA P MWR csrimh MQRELH pt L 3339
Cdd:COG5032 1571 L L S KI G KEH PQA LV F TL R S --------- AIESTAL S KESVAL S LE N K S --------- R THD P SLV ------ KEALEL -- S 1624
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3340 LSSLEGIV dq MVWFRENW he EV L R QL QQG L A kcy S VAFEK S G A VSDA K I tphtlnf VKKLVST F GV GL ENV S NV S t M F SS 3419
Cdd:COG5032 1625 DENIRIAY -- PLLHLLFE -- PI L A QL LSR L S --- S ENNKI S V A LLID K P ------- LHEEREN F PS GL SLS S FQ S - S F LK 1689
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3420 AASESLA R RAQ ataqdpvf Q K L K GQFT tdfdf SVPG S M KL hn L IS K L KKWI K I L EAKTKQLP K F f LIEEKCR F LSNF saq 3499
Cdd:COG5032 1690 ELIKKSP R KIR -------- K K F K IDIS ----- LLNL S R KL -- Y IS V L RSIR K R L KRLLELRL K K - VSPKLLL F HAFL --- 1750
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3500 ta E VEI PG EF L MP KP T hyy IK I A RF M P R V EI V QK H NTAA RRL Y IRG HN GK I Y PYL V MN dac LTES R RE E RV LQL L RL L N P 3579
Cdd:COG5032 1751 -- E IKL PG QY L LD KP F --- VL I E RF E P E V SV V KS H LQRP RRL T IRG SD GK L Y SFI V KG --- GDDL R QD E LA LQL I RL M N K 1822
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3580 C L E K R KET TK R H L FFTVPR V VAV SP QMRLV E DN P S S LS L VE I YKQRCAK K G I E hdnpisryydrlatvqargtqashqip 3659
Cdd:COG5032 1823 I L K K D KET RR R D L WIRPYK V IPL SP GSGII E WV P N S DT L HS I LREYHKR K N I S --------------------------- 1875
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3660 algw E D FVQGCVE R QEAAV L appq V L R D ILKEVQSNMV P r SM L KE W ALHT FPN AT D YW T F R KM F TIQ LA LIGFAEFV L H L 3739
Cdd:COG5032 1876 ---- I D QEKKLAA R LDNLK L ---- L L K D EFFTKATLKS P - PV L YD W FSES FPN PE D WL T A R TN F ARS LA VYSVIGYI L G L 1946
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3740 NRLN P EMLQ I AQDT G KLNVAY F R F DIND A T G DLDANRP VPFRLT P NI S E FLTTI GV S G PLTASMIAVS R CFAQPNFKVDG 3819
Cdd:COG5032 1947 GDRH P GNIL I DRSS G HVIHID F G F ILFN A P G RFPFPEK VPFRLT R NI V E AMGVS GV E G SFRELCETAF R ALRKNADSLMN 2026
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3820 I L KTVL RD EI I A W hk KTQEDTSSAL saagqpe N MDSQQLVSLVQKAVTAVMTRLHN la QFDGGE S k V NT L VAA A NSLDN L 3899
Cdd:COG5032 2027 V L ELFV RD PL I E W -- RRLPCFREIQ ------- N NEIVNVLERFRLKLSEKDAEKFV -- DLLINK S - V ES L ITQ A TDPFQ L 2094
1370
....*....|.
gi 1958668068 3900 CR M DPA W H P WL 3910
Cdd:COG5032 2095 AT M YIG W M P FW 2105
PI3Kc
smart00146 Phosphoinositide 3-kinase, catalytic domain; Phosphoinositide 3-kinase isoforms participate in ...
3564-3797
1.00e-17
Phosphoinositide 3-kinase, catalytic domain; Phosphoinositide 3-kinase isoforms participate in a variety of processes, including cell motility, the Ras pathway, vesicle trafficking and secretion, and apoptosis. These homologues may be either lipid kinases and/or protein kinases: the former phosphorylate the 3-position in the inositol ring of inositol phospholipids. The ataxia telangiectesia-mutated gene produced, the targets of rapamycin (TOR) and the DNA-dependent kinase have not been found to possess lipid kinase activity. Some of this family possess PI-4 kinase activities.
Pssm-ID: 214538 [Multi-domain]
Cd Length: 240
Bit Score: 85.43
E-value: 1.00e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3564 S R RE ERVLQLLRL L N PC L E K R KET TK R H L FFTVPR V VAVS P QMR L V E DN P S S LS L V EI Y K QRCAK KG IEH D NP isryydr 3643
Cdd:smart00146 9 L R QD ERVLQLLRL M N KL L Q K D KET RR R D L HLRPYK V IPTG P KSG L I E VV P N S TT L H EI L K EYRKQ KG KVL D LR ------- 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3644 latvqargtqashqipalgwedfvqgcve R Q E A AV L APPQVLRD ilkev QSNMV P RSM L KE W ALHT FP N - AT DY WTF RK M 3722
Cdd:smart00146 82 ----------------------------- S Q T A TR L KKLELFLE ----- ATGKF P DPV L YD W FTKK FP D p SE DY FEA RK N 127
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958668068 3723 FT IQL A LIGFAEFV L H L NRLNPEMLQIA q D TG K L NVAY F R F DINDATGDLDANRP VPFRLTP N ise FLTTI G V SG 3797
Cdd:smart00146 128 FT RSC A GYSVITYI L G L GDRHNDNIMLD - K TG H L FHID F G F ILGNGPKLFGFPER VPFRLTP E --- MVDVM G D SG 198
PI3_PI4_kinase
pfam00454 Phosphatidylinositol 3- and 4-kinase; Some members of this family probably do not have lipid ...
3564-3832
2.32e-12
Phosphatidylinositol 3- and 4-kinase; Some members of this family probably do not have lipid kinase activity and are protein kinases,.
Pssm-ID: 395364 [Multi-domain]
Cd Length: 241
Bit Score: 69.67
E-value: 2.32e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3564 S R RE E RV LQ LLR L LNPC L E K RKETTK R hlf FTVPR V VAVS P QMRLV E DN P S S LS L VE I YKQRCAKK giehd N P ISRYYDR 3643
Cdd:pfam00454 12 L R QD E LI LQ VFK L MDEE L S K DNLDLR R --- LKPYS V IPLG P KCGII E WV P N S ET L AY I LDEYGENG ----- V P PTAMVKI 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3644 L A tvqargtqashqi P AL GWEDF vqgcverqeaavlappqvlr DILK E VQSNMV P RSM L KE W ALHTF P N A TDYWTF RK M F 3723
Cdd:pfam00454 84 L H ------------- S AL NYPKL -------------------- KLEF E SRISLP P KVG L LQ W FVKKS P D A EEWGEA RK N F 130
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3724 TIQL A LIGFAEFV L HLNRLNPEMLQIAQD TGKL nvayfr F D I N ------ DA TG DL DANRP VPFRLT PNISEFLTTI G VS G 3797
Cdd:pfam00454 131 VRSC A GYSVLDYI L GNGDRHLDNILVDKT TGKL ------ F H I D fglclp DA GK DL PFPEK VPFRLT REMVYAMGPS G DE G 204
250 260 270
....*....|....*....|....*....|....*
gi 1958668068 3798 PLTASMIAVSRCFAQPNFKVDGI LK TVLR D EIIA W 3832
Cdd:pfam00454 205 LFRELCETAYEALRRNLNLLTNL LK LMVA D GLPD W 239
FATC
pfam02260 FATC domain; The FATC domain is named after FRAP, ATM, TRRAP C-terminal. The solution ...
3883-3910
9.96e-04
FATC domain; The FATC domain is named after FRAP, ATM, TRRAP C-terminal. The solution structure of the FATC domain suggests it plays a role in redox-dependent structural and cellular stability.
Pssm-ID: 460514 [Multi-domain]
Cd Length: 32
Bit Score: 38.90
E-value: 9.96e-04
10 20
....*....|....*....|....*...
gi 1958668068 3883 E SK V NT L VAA A NSLD NL CR M DPA W H PW L 3910
Cdd:pfam02260 5 E GQ V DE L IQE A TDPE NL AQ M YIG W C PW W 32
Name
Accession
Description
Interval
E-value
Tra1_ring
pfam20206 Tra1 HEAT repeat ring region; This entry represents part of the Tra1 protein composed of alpha ...
894-2689
0e+00
Tra1 HEAT repeat ring region; This entry represents part of the Tra1 protein composed of alpha solenoid repeats that form a ring region.
Pssm-ID: 466357
Cd Length: 1678
Bit Score: 1705.21
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 894 R V LGK F GG S NR KM LKE SQR L H Y V - VTEVQGPSITV EF s DCKASLQ LP MEK A IET A LDC L K S ANTE P Y YR R QA W E VIRCF L 972
Cdd:pfam20206 1 R I LGK L GG R NR RF LKE PPK L E Y R d AGDEASLTVEL EF - GAPSDQT LP LDP A VDL A KRT L R S STSL P H YR K QA F E LLKSA L 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 973 VAMMSLE D NKH --- A LY Q LLAH P NFTE K T ------- IPSVIISHRY - KA QDTPARKT F E QAL T G A F MS A V IK D LR PS ALP 1041
Cdd:pfam20206 80 ALLLDSD D SPD dll A RL Q AAIQ P LLEV K I eseapsd LSNLNTDDSA a KA KAEEQEEL F K QAL K G L F FA A S IK E LR AE ALP 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1042 F VAS L I RH Y T MVAV A QQC GPF LLPCYQV gsqpstamfhs EEN G S kg M DPLV L IDAI AICMAY E E KEL CKI GE VA L AV I F D 1121
Cdd:pfam20206 160 F LKG L L RH F T LLEL A EEI GPF KESRRRF ----------- NLE G P -- L DPLV F IDAI VESLSS E S KEL RDA GE SV L KL I L D 226
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1122 VASII LGSKE RAC QL -- PLF S Y IVE R L C AC CYE Q AWY A KLGG VVS I KF L M ER -- L P L T WVL QN Q QT F LK ALLFV MM D LTG 1197
Cdd:pfam20206 227 TLVTL LGSKE VVD QL ne PLF H Y LAS R F C HL CYE E AWY R KLGG CLG I RI L L ER ld L G L K WVL DH Q LE F VR ALLFV LK D MPP 306
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1198 EV SN G A V AM AK T TL EQL L MR C A TP L K DEERAE E IVVA Q EKSFHHVTHD LV R E VT S P N ST VR KQ A MHS L QV LA QV TG KS VT 1277
Cdd:pfam20206 307 EV PS G N V DD AK D TL LFI L KV C N TP P K STPKTT E GTAK Q RSKLNTLVGL LV S E LS S S N EI VR ET A QKA L EL LA EL TG IP VT 386
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1278 VIM EP H KE V L q DMVPPK K H L l R HQ P ANA QIG LMEGN TFC TT L Q P R L FTMDLNV V E hkv FYT E L L N L CE AED S AL TKL - P C 1356
Cdd:pfam20206 387 ELL EP V KE R L - LQPIFT K P L - R AL P FPM QIG HIDAI TFC LS L R P P L LEFNEEL V R --- LLH E A L A L AD AED A AL VGR n P Q 461
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1357 YK S L PS L VP LR I A ALNA L A A CNYL P -------- QS R EK II AAL FK A L N S TNS E LQE A GEACMRKF L - EGATIEV D QIH T H 1427
Cdd:pfam20206 462 YK N L TQ L IQ LR V A CIRL L S A AMAC P dflapkqv NT R NR II SVF FK S L Y S RSP E VVD A AHDGLKQV L a QQQKLPK D LLQ T G 541
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1428 M RP L LM M L G D YRS LT LNVVNR L TSVTR L FP N S F NDKFCDQMMQ HLRKW ME vvvithkggqrsdg N E S L S E C grc SL S P F c 1507
Cdd:pfam20206 542 L RP I LM N L S D HKR LT VAGLEG L ARLLE L LT N Y F KVEIGEKLLD HLRKW AD -------------- P E M L Q E A --- SL K P L - 603
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1508 qfepav E GV EE M KI CS AI I N L FHL I P A A PQTLVKP L LEV V MKT E RAMLIEAG SPFREPL I K F L T R H P SQT VE L F M me AT L 1587
Cdd:pfam20206 604 ------ E EN EE V KI AA AI L N I FHL L P P A ASKFLED L VKL V IQL E AVLRRYVS SPFREPL A K Y L N R Y P EEA VE F F L -- ER L 675
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1588 N DP QW SR M F MSF LK HK DA R PLR DVLAAN P N R FIT L LLPGGAQ TA vrpgspsts NMRLD L QF Q AIK I ISII VK NDDA WL AN 1667
Cdd:pfam20206 676 S DP RY SR L F RDI LK SP DA E PLR AEVSSK P S R VSL L NIKLFLE TA --------- DSKTA L RY Q GLL I VRTL VK LNPN WL PS 746
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1668 QHSLVSQ L RRV W V S ETFQE R HRK E NMAATN -- WK E P KLL AFC LL N Y CKR N YG DI E LLF Q LL RA FT GRFLCNMT FL KEYME 1745
Cdd:pfam20206 747 NNDVLQA L LQL W R S LHRLQ R LGN E DSLIHF qq LR E S KLL LKI LL Q Y LRQ N PD DI D LLF D LL EI FT LPTVTDFS FL RDFLY 826
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1746 EE IPKN YS IA QKRA LFF RF V E - F N DP NFGDE LK A K V L Q H IL NP AFLY SFE K GE G - E Q L L gppnpegd NPES I TS v FIT K V 1823
Cdd:pfam20206 827 EE VALK YS VE QKRA ILL RF L E m F P DP TTSQD LK V K A L R H LI NP ILAA SFE R GE S k E E L V -------- DADV I DQ - LHA K I 897
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1824 LD P EKQ A DML ----- D S LRI Y LLQ YA TLLVE H A PHH I HD N N K N rnsklrr L MT FAW PC L LS kac V DP AC K YSGHL L L A HI 1898
Cdd:pfam20206 898 WK P LQL A GDD atfsd D G LRI E LLQ LS TLLVE Y A SEL I GE N R K D ------- L IK FAW NF L KL --- D DP TV K QAAYV L I A RF 967
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1899 I AK F AIHK KIVLQV FHS LLKAH AM E A RA I VRQA MA IL T PA V P A R M -- ED G HQMLTH WT RK I I VEEGH TV PQLVHI LH LIV 1976
Cdd:pfam20206 968 I EA F DTPP KIVLQV YVA LLKAH QP E G RA L VRQA LD IL A PA L P K R L pe NP G YPTWVK WT KR I L VEEGH SI PQLVHI YQ LIV 1047
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 1977 Q H FKVY YP V R HHL V Q HMV SAM Q R LG FT P SV T I E Q R R LAVDL S E VV I K WE LQ R IKDQQPDSDMDPN SGG E gvnsvsi K RGL 2056
Cdd:pfam20206 1048 R H PDLF YP N R ELF V P HMV TSL Q K LG LP P NA T T E T R K LAVDL A E LI I R WE RR R SESMDVSESSNEE SGG D ------- K QTV 1120
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2057 SV DS AQEV K R F RAATGAISAV fgrsqsl P GAD SLLAK PI DKQHTD TVVNFLIR V AC qvndn T N T AG S PGEV LS R R CVN LL 2136
Cdd:pfam20206 1121 PL DS SSSP K S F ASSSASADPT ------- M GAD DSSNY PI PLSLRE TVVNFLIR F AC ----- T S T ED S SSKG LS A R ALE LL 1188
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2137 K TA L R PD M W CKSEL KL QW F D K L L MTV E q PNQVNYGN IC TG LE V LN FL L T V LQSPA I L S SFKP LQ RGIAA C MTCG N T K VLR 2216
Cdd:pfam20206 1189 K DL L S PD L W PDVSI KL SF F E K V L AQT E - VSENSIPQ IC NA LE I LN IV L E V KPNAW I I S NLSQ LQ KLLEK C LKSD N P K IQE 1267
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2217 A VHSL L S R LMSIF P TEPST S SV A sky EE LECL Y AAVGKV I Y EGL TNYEKA tsanps Q L F GTL MI L KSACCNN P S YID RL I 2296
Cdd:pfam20206 1268 A LRPI L K R ILEAL P VSVEG S ED A --- EE VSSF Y KFIETI I T EGL SSLTNT ------ G L L GTL SL L SAWAKHR P D YID PF I 1338
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2297 SVF M RS LQK M V R EHL -- N P Q A AS G S TEATAAG -- AS EL VMLS L D L V K T R LAVMS m E M R KN F IQ t I L TS LIEKS P D AKI LR 2372
Cdd:pfam20206 1339 PSL M KV LQK L V K EHL aa N S Q D AS S S SASPPPF es TA EL LIKT L E L L K L R VSHLG - E Q R RW F LS - A L VQ LIEKS N D VEL LR 1416
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2373 AVVKI V E EW V K nnsp MAANQT PT LR EK SI LLVKMM TYI ekr F PE D LE L N A Q FLDL VNYV Y R D E AL SG SELT AK LEPAFL S 2452
Cdd:pfam20206 1417 TILDM V R EW I K ---- EQTEGF PT IK EK AG LLVKMM SFE --- F RG D AA L S A D FLDL ILDI Y E D P AL AR SELT VR LEPAFL M 1489
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2453 GLR CAQ P L IR A KFF EV FDNS MK R RVY ERLLY VTCS QNWE AM G S H F WIKQ CIE LLL AVCE K STAIGT S CQG A ML PS I T NVI 2532
Cdd:pfam20206 1490 GLR SSD P K IR K KFF AI FDNS LS R SLA ERLLY ILGV QNWE SL G D H Y WIKQ ALD LLL GSVD K DNPLSL S ESS A SI PS L T ALE 1569
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2533 nladshdraafamvthvkqeprerenseskeedveidielapgdqtst PKT KE L S EKDIGNQ L HM L TNR H DK FLD T LR E V 2612
Cdd:pfam20206 1570 ------------------------------------------------ EAD KE E S YEMEDDE L DK L LSG H RA FLD E LR S V 1601
1770 1780 1790 1800 1810 1820 1830
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958668068 2613 KT G A LL SAFV QL C H ISTT L AE K T WV Q LFP RL W KI LS D R Q Q HA L AGE I S P F L CSGS H QV Q R D CQ P SALNCFV E AMSQ C 2689
Cdd:pfam20206 1602 TL G D LL DPLR QL L H QDSN L TH K L WV S LFP AA W SA LS R R E Q ED L TKA I V P L L SKDY H SK Q A D KR P NVIQTLL E GVAR C 1678
Tra1_central
pfam20175 Tra1 HEAT repeat central region; This entry represents part of the Tra1 protein composed of ...
276-882
0e+00
Tra1 HEAT repeat central region; This entry represents part of the Tra1 protein composed of alpha solenoid repeats that forms the central region. This is named as central due to its position relative to the ring region.
Pssm-ID: 466326
Cd Length: 593
Bit Score: 739.06
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 276 LY A DFIAAQ I KTLSFLAY II R IYQ E LVTK Y SQQMVKGMLQ LL SN CP A E TAHL RKELL I A AK HIL T TE L R NQ F I P CM D K L F 355
Cdd:pfam20175 1 LY G DFIAAQ V KTLSFLAY LL R GFA E QLRP Y QDKLPEIVVR LL QD CP P E ASST RKELL V A TR HIL S TE F R SG F V P HI D L L L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 356 DE SI LIG S G Y T AR ETLRPLAYS T LADL V HHVR QH L PLSD LS LA V QLFA KN ID D ES LP S SIQTMS C KLLLNLVD C I RS K SE 435
Cdd:pfam20175 81 DE KV LIG T G V T SY ETLRPLAYS M LADL I HHVR AE L SIEQ LS KV V SIYS KN LH D PT LP P SIQTMS A KLLLNLVD S I VK K DD 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 436 QESGNG RD V L M R M LE V FV L K FHTIA RY Q --- L SAIF KK CKPQS E LGA A EAALPGVPT A PAAPGPAPSPAPVPAP pppppp 512
Cdd:pfam20175 161 KDPQEA RD L L V R I LE T FV E K LKSLN RY Y ppl L KQHR KK KSEKE E KTS A DVDADEDRP A DIDTVEYLAIERAKPI ------ 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 513 apapatpvtpapvppfek Q G EKDKEDKQTFQVT D C R S L V KTL VC G V KTI T WG ITS C KAPGEA Q FI P NKQLQ ------ P K E 586
Cdd:pfam20175 235 ------------------ E G IQFPSPSPVDPLK D A R F L F KTL LH G L KTI I WG LRN C QPTPPQ Q NA P SGWNS varglp P E E 296
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 587 TQ I Y I K L V K YAMQAL D I Y Q vq I AGNGQ T YIRVANCQTVRM KEEKEVLE H FA GV FT MMN P L TF K E I F QTTV P YMV ERI SK N 666
Cdd:pfam20175 297 VD I F I R L F K EGVKCF D L Y S -- I NKDPP T TASSSSISRTSS KEEKEVLE L FA SI FT ILD P A TF Q E V F TSRM P FLF ERI LE N 374
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 667 Y AL QIVANS FL A N PTT S AL FA T IL VEY L LE RL PEM G S - NVEL S NLY L K LFKL V F GS V S LF AA ENE QM L K PHL H K IVNS S M 745
Cdd:pfam20175 375 P AL LAIPQF FL S N DSV S PR FA S IL LRF L VD RL EDL G A a DKKK S SVL L R LFKL A F MA V T LF PE ENE AV L Q PHL P K LILT S L 454
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 746 E LA QT AKEP Y NYFLLLRALFRSIGGG SHD LLY Q E F LPLLP N LL Q GLN M L Q S GL H KQH M K DLFVELCLTVPVRLS S LLPYL 825
Cdd:pfam20175 455 K LA LK AKEP L NYFLLLRALFRSIGGG RFE LLY K E V LPLLP V LL E GLN R L L S SA H RPS M R DLFVELCLTVPVRLS V LLPYL 534
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*..
gi 1958668068 826 PM LM D PLV S ALN G S QT LVSQGLRTLELCVDNL Q P D FL YDHI QPV RAE LMQALW RT LR 882
Cdd:pfam20175 535 SL LM K PLV L ALN S S PE LVSQGLRTLELCVDNL T P E FL DPIM QPV IDD LMQALW KH LR 591
PIKK_TRRAP
cd05163 Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein; TRRAP belongs ...
3521-3834
1.04e-115
Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein; TRRAP belongs to the the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. It contains a FATC (FRAP, ATM and TRRAP, C-terminal) domain and has a large molecular weight. Unlike most PIKK proteins, however, it contains an inactive PI3K-like pseudokinase domain, which lacks the conserved residues necessary for ATP binding and catalytic activity. TRRAP also contains many motifs that may be critical for protein-protein interactions. TRRAP is a common component of many histone acetyltransferase (HAT) complexes, and is responsible for the recruitment of these complexes to chromatin during transcription, replication, and DNA repair. TRRAP also exists in non-HAT complexes such as the p400 and MRN complexes, which are implicated in ATP-dependent remodeling and DNA repair, respectively. The TRRAP pseudokinase domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and RIO kinases.
Pssm-ID: 270707
Cd Length: 252
Bit Score: 367.62
E-value: 1.04e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3521 IARF M PRVEIV QK H N T AA RRL Y IRGH N G KI YP Y LV MNDACLT e SRREERV L QL L RLLN PC LE KR KET TK R H L F F T VP R VV 3600
Cdd:cd05163 1 IARF L PRVEIV RR H G T CY RRL T IRGH D G SK YP F LV QTPSARH - SRREERV M QL F RLLN RV LE RK KET RR R N L Q F H VP I VV 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3601 AV SPQ M RLVED N PS SL SL VE IY K qrcakkgiehdnpisryydrlatvqargtqashqipalgwedfvqgcverqeaavla 3680
Cdd:cd05163 80 PL SPQ V RLVED D PS YI SL QD IY E --------------------------------------------------------- 102
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3681 ppqv LRD IL K E V QS N MVP RSM L KEWA L H T F P NAT D Y W T FRK M FT I QLAL IG F AEF VL H L NRLN P EMLQ I AQD TG KLNVAY 3760
Cdd:cd05163 103 ---- KLE IL N E I QS K MVP ETI L SNYF L R T M P SPS D L W L FRK Q FT L QLAL SS F MTY VL S L GNRT P HRIL I SRS TG NVFMTD 178
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958668068 3761 F RFD IN DATGD LD A N R PVPFRLTPNI SE F LTT IGV S G P LT A SM I A VS R CFAQ P NFKVDGI L KTVL RDE I I A WHK 3834
Cdd:cd05163 179 F LPS IN SQGPL LD N N E PVPFRLTPNI QH F IGP IGV E G L LT S SM M A IA R ALTE P EYDLEQY L SLFV RDE L I S WHK 252
PIKKc
cd05164 Catalytic domain of Phosphoinositide 3-kinase-related protein kinases; PIKK subfamily members ...
3521-3827
9.60e-79
Catalytic domain of Phosphoinositide 3-kinase-related protein kinases; PIKK subfamily members include ATM (Ataxia telangiectasia mutated), ATR (Ataxia telangiectasia and Rad3-related), TOR (Target of rapamycin), SMG-1 (Suppressor of morphogenetic effect on genitalia-1), and DNA-PK (DNA-dependent protein kinase). PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain, similar to that of lipid PI3K, and their large molecular weight (240-470 kDa). They show strong preference for phosphorylating serine/threonine residues followed by a glutamine and are also referred to as (S/T)-Q-directed kinases. They all contain a FATC (FRAP, ATM and TRRAP, C-terminal) domain. PIKKs have diverse functions including cell-cycle checkpoints, genome surveillance, mRNA surveillance, and translation control. The PIKK catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and RIO kinases.
Pssm-ID: 270708 [Multi-domain]
Cd Length: 222
Bit Score: 260.67
E-value: 9.60e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3521 IA R F M PRV E I VQKH n TAARRLY I R G HN GK I YP Y LV MN D AC L tes R RE ERV L QL LR LLN PC LEK R KET T KR H L FFTVPR VV 3600
Cdd:cd05164 1 IA S F D PRV R I LASL - QKPKKIT I L G SD GK E YP F LV KG D DD L --- R KD ERV M QL FQ LLN TL LEK D KET R KR N L TIRTYS VV 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3601 AV S P Q MR L V E DNPSSLS L veiykqrcakkgiehdnpisryydrlatvqargtqashqipalgwedfvqgcverqeaavla 3680
Cdd:cd05164 77 PL S S Q SG L I E WVDNTTT L -------------------------------------------------------------- 94
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3681 ppqvlrdilkevqsnmvp RSM LK E W ALH TFP NA T DYWTF R KMF T IQL A LIGFAEFVLH L NRLNP E MLQ I AQD TG KLNVAY 3760
Cdd:cd05164 95 ------------------ KPV LK K W FNE TFP DP T QWYEA R SNY T KST A VMSMVGYIIG L GDRHL E NIL I DTK TG EVVHID 156
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958668068 3761 F RFDI N DATGDLD a NRP VPFRLT P NI SEFLTTI GV S G PLTA S MIA V S R C F AQPNF K VDGI L K T V L R D 3827
Cdd:cd05164 157 F GMIF N KGKTLPV - PEI VPFRLT R NI INGMGPT GV E G LFRK S CEQ V L R V F RKHKD K LITF L D T F L Y D 222
FAT
pfam02259 FAT domain; The FAT domain is named after FRAP, ATM and TRRAP.
2858-3211
2.83e-77
FAT domain; The FAT domain is named after FRAP, ATM and TRRAP.
Pssm-ID: 396714 [Multi-domain]
Cd Length: 342
Bit Score: 261.13
E-value: 2.83e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2858 L VL E C AWR VSN W TA M K E A L VQVEVSC P KE mawrv NMYRGY LA ICH pee Q Q LSFI ER LV E M A SS L AIR E WRR L PHVVSHVH 2937
Cdd:pfam02259 3 L AA E A AWR LGQ W DL M R E Y L SLMKKDS P DK ----- AFFEAI LA LHR --- N Q FDEA ER YI E K A RQ L LDT E LSA L SGESYNRA 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2938 T PLL QAA QQ II EL Q E AA Q INAG L Q ptnlgrn N S LHDM K TVVK TWRNRLP IVS DD LSH W SSVFMW R QHHYQ gkptwsgmhs 3017
Cdd:pfam02259 75 Y PLL VRL QQ LA EL E E II Q YKQK L G ------- Q S SEEL K SLLQ TWRNRLP GCQ DD VEI W QDILTV R SLVLS ---------- 137
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3018 ssivtayensshhd P SSNNAML G V H as A SAIIQYGKI ARK Q G LVNV A LDI L SRI ------------------ HTI PT VPI 3079
Cdd:pfam02259 138 -------------- P IEDVYLG G Y H -- A EMWLKFANL ARK S G RFSL A EKA L LKL lgedpeewlpevvyayak YLW PT GEQ 201
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3080 VDCFQ K I R QQVK CYLQ lagvm GKN E CMQ GLEVI ES TNL KY FT KEM t A EF Y A LKG MFL A QINK ------ SEE ANK A FSA A V 3153
Cdd:pfam02259 202 QEALL K L R EFLS CYLQ ----- KNG E LLS GLEVI NP TNL EE FT ELL - A RC Y L LKG KWQ A ALGQ nwaeek SEE ILQ A YLL A T 275
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958668068 3154 Q MHDVLV KAW AM W GDYLESIFV KE R Q L ---------- HLG V S A ITC YL HACRHQN E s K S RKYLAKV L W 3211
Cdd:pfam02259 276 Q FDPSWY KAW HT W ALFNFEVLR KE E Q G keeegpedls RYV V P A VEG YL RSLSLSS E - N S LQDTLRL L T 342
TEL1
COG5032 Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms];
2552-3910
9.94e-68
Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms];
Pssm-ID: 227365 [Multi-domain]
Cd Length: 2105
Bit Score: 256.63
E-value: 9.94e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2552 E PRERENSES K EEDVEI d IELAPGDQ T STPKTKELSEKDIGNQLHMLTNRHDKF L DT L revktga LLSAFVQ LC HISTT L 2631
Cdd:COG5032 966 E CWLELMNSY K RLLIKS - LKSKLHLP T IPILILQMLLDSKNLTEFTEHQLKNLP L PS L ------- SIGFYES LC SFLAK L 1037
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2632 AEKTWVQL FP R L WKIL sdrqqhalage ISPF L CSGS H QV Q R D cqp SAL N CFVEAM S QCV pp IPMR P CVL KYL GKTHNLWF 2711
Cdd:COG5032 1038 LHDEELYF FP L L FVSS ----------- LETL L SVNY H IN Q L D --- LRP N ILKHFG S FVR -- FQLK P HLV KYL QRWYEALN 1101
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2712 R STLM L EHQAFEKGL S lpikpkqtaefyeqes I T PPQQEILDSLA ELYS L L Q E E DM WAG L WQK R c K FS ET AT A I AYEQ H G 2791
Cdd:COG5032 1102 R YFEL L SKGDRLFAI S ---------------- F T KLRNVDALGKL ELYS S L A E I DM FLS L HRR R - K LL ET LV A T AYEQ V G 1164
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2792 FFEQ AQ ES YE K A MD KA KKEHERSNA spaifp E Y QL W EDHW I R C SKE L NQWE A ltefgq SKGHINPY -- L V LE CA WR VSNW 2869
Cdd:COG5032 1165 EWYK AQ QL YE V A QR KA RSKEFPFSL ------ Q Y LY W HIND I D C ADK L QSVL A ------ ELSLVTGI se L L LE ES WR RALF 1232
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2870 TAM K EA L VQVEVSCPKE M AWRVNMYRGYLAICHPE E QQLSFI E -- RLVEMASS L AIRE W RR L PH VVS HVHT P L L Q aa QQI 2947
Cdd:COG5032 1233 SNI K DS L ESELEEIIDG M YKSNEDFGALMLLSLSA E LWDKIL E gr SSCSKSIK L SLNI W LD L SI VVS PKDE P E L F -- IKF 1310
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 2948 I EL Q EA AQ I NAG L QPT N L grn NS L HDMKTVV K ---- T W R N RLP IVSDD L SHWSSVFM WRQ HH - YQGK P TWSGMH SS SI - V 3021
Cdd:COG5032 1311 V EL C EA SS I RSK L LEK N I --- QE L LEKLEEI K splg T L R D RLP PPWAL L DLKRLLAT WRQ NA f LRIN P ELLPLL SS LL n L 1387
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3022 TAYEN S SHHDPSSN namlgv HA SA SA I IQYGKI ARK qgl VNVALDI L SR I HTIPTVP I VDC F QKI R QQVK C Y L Q lagvmg 3101
Cdd:COG5032 1388 QSSSL S KQLVSRGS ------ SE SA IS I NSFASV ARK --- HFLPDNQ L KK I YQLSNIL I SEA F LLL R YLLL C R L G ------ 1452
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3102 KN E CMQ GL E V IES TNL KY F tkemtaefyalkgmflaqinkseeankafsaavqm H D VLVKAWAM WG -- DY L E SI FVKERQ 3179
Cdd:COG5032 1453 RR E LKA GL N V WNL TNL EL F ----------------------------------- S D IQESEFFE WG kn LK L L SI IPPIEE 1497
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3180 LH L GV s A IT CYL HA crh QNES K SRKYLAKVLW LLS FD D DKNTLADAVDKYCIGVPP I QW law IPQLL TC L VGSEGKLLLN 3259
Cdd:COG5032 1498 IF L SN - A LS CYL QV --- KDLL K KLNLFELLGS LLS AK D AAGSYYKNFHIFDLEISV I PF --- IPQLL SS L SLLDLNSAQS 1570
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3260 L I S QV G RVY PQA VY F PI R T lyltlkieq RERYKSD S GQQQPS S VG N Q S hsasdpgpi R ATA P MWR csrimh MQRELH pt L 3339
Cdd:COG5032 1571 L L S KI G KEH PQA LV F TL R S --------- AIESTAL S KESVAL S LE N K S --------- R THD P SLV ------ KEALEL -- S 1624
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3340 LSSLEGIV dq MVWFRENW he EV L R QL QQG L A kcy S VAFEK S G A VSDA K I tphtlnf VKKLVST F GV GL ENV S NV S t M F SS 3419
Cdd:COG5032 1625 DENIRIAY -- PLLHLLFE -- PI L A QL LSR L S --- S ENNKI S V A LLID K P ------- LHEEREN F PS GL SLS S FQ S - S F LK 1689
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3420 AASESLA R RAQ ataqdpvf Q K L K GQFT tdfdf SVPG S M KL hn L IS K L KKWI K I L EAKTKQLP K F f LIEEKCR F LSNF saq 3499
Cdd:COG5032 1690 ELIKKSP R KIR -------- K K F K IDIS ----- LLNL S R KL -- Y IS V L RSIR K R L KRLLELRL K K - VSPKLLL F HAFL --- 1750
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3500 ta E VEI PG EF L MP KP T hyy IK I A RF M P R V EI V QK H NTAA RRL Y IRG HN GK I Y PYL V MN dac LTES R RE E RV LQL L RL L N P 3579
Cdd:COG5032 1751 -- E IKL PG QY L LD KP F --- VL I E RF E P E V SV V KS H LQRP RRL T IRG SD GK L Y SFI V KG --- GDDL R QD E LA LQL I RL M N K 1822
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3580 C L E K R KET TK R H L FFTVPR V VAV SP QMRLV E DN P S S LS L VE I YKQRCAK K G I E hdnpisryydrlatvqargtqashqip 3659
Cdd:COG5032 1823 I L K K D KET RR R D L WIRPYK V IPL SP GSGII E WV P N S DT L HS I LREYHKR K N I S --------------------------- 1875
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3660 algw E D FVQGCVE R QEAAV L appq V L R D ILKEVQSNMV P r SM L KE W ALHT FPN AT D YW T F R KM F TIQ LA LIGFAEFV L H L 3739
Cdd:COG5032 1876 ---- I D QEKKLAA R LDNLK L ---- L L K D EFFTKATLKS P - PV L YD W FSES FPN PE D WL T A R TN F ARS LA VYSVIGYI L G L 1946
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3740 NRLN P EMLQ I AQDT G KLNVAY F R F DIND A T G DLDANRP VPFRLT P NI S E FLTTI GV S G PLTASMIAVS R CFAQPNFKVDG 3819
Cdd:COG5032 1947 GDRH P GNIL I DRSS G HVIHID F G F ILFN A P G RFPFPEK VPFRLT R NI V E AMGVS GV E G SFRELCETAF R ALRKNADSLMN 2026
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3820 I L KTVL RD EI I A W hk KTQEDTSSAL saagqpe N MDSQQLVSLVQKAVTAVMTRLHN la QFDGGE S k V NT L VAA A NSLDN L 3899
Cdd:COG5032 2027 V L ELFV RD PL I E W -- RRLPCFREIQ ------- N NEIVNVLERFRLKLSEKDAEKFV -- DLLINK S - V ES L ITQ A TDPFQ L 2094
1370
....*....|.
gi 1958668068 3900 CR M DPA W H P WL 3910
Cdd:COG5032 2095 AT M YIG W M P FW 2105
PI3Kc
smart00146 Phosphoinositide 3-kinase, catalytic domain; Phosphoinositide 3-kinase isoforms participate in ...
3564-3797
1.00e-17
Phosphoinositide 3-kinase, catalytic domain; Phosphoinositide 3-kinase isoforms participate in a variety of processes, including cell motility, the Ras pathway, vesicle trafficking and secretion, and apoptosis. These homologues may be either lipid kinases and/or protein kinases: the former phosphorylate the 3-position in the inositol ring of inositol phospholipids. The ataxia telangiectesia-mutated gene produced, the targets of rapamycin (TOR) and the DNA-dependent kinase have not been found to possess lipid kinase activity. Some of this family possess PI-4 kinase activities.
Pssm-ID: 214538 [Multi-domain]
Cd Length: 240
Bit Score: 85.43
E-value: 1.00e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3564 S R RE ERVLQLLRL L N PC L E K R KET TK R H L FFTVPR V VAVS P QMR L V E DN P S S LS L V EI Y K QRCAK KG IEH D NP isryydr 3643
Cdd:smart00146 9 L R QD ERVLQLLRL M N KL L Q K D KET RR R D L HLRPYK V IPTG P KSG L I E VV P N S TT L H EI L K EYRKQ KG KVL D LR ------- 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3644 latvqargtqashqipalgwedfvqgcve R Q E A AV L APPQVLRD ilkev QSNMV P RSM L KE W ALHT FP N - AT DY WTF RK M 3722
Cdd:smart00146 82 ----------------------------- S Q T A TR L KKLELFLE ----- ATGKF P DPV L YD W FTKK FP D p SE DY FEA RK N 127
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958668068 3723 FT IQL A LIGFAEFV L H L NRLNPEMLQIA q D TG K L NVAY F R F DINDATGDLDANRP VPFRLTP N ise FLTTI G V SG 3797
Cdd:smart00146 128 FT RSC A GYSVITYI L G L GDRHNDNIMLD - K TG H L FHID F G F ILGNGPKLFGFPER VPFRLTP E --- MVDVM G D SG 198
PI3_PI4_kinase
pfam00454 Phosphatidylinositol 3- and 4-kinase; Some members of this family probably do not have lipid ...
3564-3832
2.32e-12
Phosphatidylinositol 3- and 4-kinase; Some members of this family probably do not have lipid kinase activity and are protein kinases,.
Pssm-ID: 395364 [Multi-domain]
Cd Length: 241
Bit Score: 69.67
E-value: 2.32e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3564 S R RE E RV LQ LLR L LNPC L E K RKETTK R hlf FTVPR V VAVS P QMRLV E DN P S S LS L VE I YKQRCAKK giehd N P ISRYYDR 3643
Cdd:pfam00454 12 L R QD E LI LQ VFK L MDEE L S K DNLDLR R --- LKPYS V IPLG P KCGII E WV P N S ET L AY I LDEYGENG ----- V P PTAMVKI 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3644 L A tvqargtqashqi P AL GWEDF vqgcverqeaavlappqvlr DILK E VQSNMV P RSM L KE W ALHTF P N A TDYWTF RK M F 3723
Cdd:pfam00454 84 L H ------------- S AL NYPKL -------------------- KLEF E SRISLP P KVG L LQ W FVKKS P D A EEWGEA RK N F 130
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3724 TIQL A LIGFAEFV L HLNRLNPEMLQIAQD TGKL nvayfr F D I N ------ DA TG DL DANRP VPFRLT PNISEFLTTI G VS G 3797
Cdd:pfam00454 131 VRSC A GYSVLDYI L GNGDRHLDNILVDKT TGKL ------ F H I D fglclp DA GK DL PFPEK VPFRLT REMVYAMGPS G DE G 204
250 260 270
....*....|....*....|....*....|....*
gi 1958668068 3798 PLTASMIAVSRCFAQPNFKVDGI LK TVLR D EIIA W 3832
Cdd:pfam00454 205 LFRELCETAYEALRRNLNLLTNL LK LMVA D GLPD W 239
PIKKc_ATR
cd00892 Catalytic domain of Ataxia telangiectasia and Rad3-related proteins; ATR is also referred to ...
3521-3834
3.76e-08
Catalytic domain of Ataxia telangiectasia and Rad3-related proteins; ATR is also referred to as Mei-41 (Drosophila), Esr1/Mec1p (Saccharomyces cerevisiae), Rad3 (Schizosaccharomyces pombe), and FRAP-related protein (human). ATR contains a UME domain of unknown function, a FAT (FRAP, ATM and TRRAP) domain, a catalytic domain, and a FATC domain at the C-terminus. Together with its downstream effector kinase, Chk1, ATR plays a central role in regulating the replication checkpoint. ATR stabilizes replication forks by promoting the association of DNA polymerases with the fork. Preventing fork collapse is essential in preserving genomic integrity. ATR also plays a role in normal cell growth and in response to DNA damage. ATR is a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain, similar to that of lipid PI3K, and their large molecular weight (240-470 kDa). The ATR catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and RIO kinases.
Pssm-ID: 270625 [Multi-domain]
Cd Length: 237
Bit Score: 57.13
E-value: 3.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3521 I AR F MPR VEI V --- QK hnta ARRLYIR G HN GK I YP Y L VMNDAC L tes R REE R VLQLLR L L N PC L E K RK E TTK R H L FF tvp 3597
Cdd:cd00892 1 I SG F EDE VEI M psl QK ---- PKKITLV G SD GK K YP F L CKPKDD L --- R KDA R MMEFNT L I N RL L S K DP E SRR R N L HI --- 70
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3598 R VV AV S P qmr L V E DN pssl SLV E iykqrcakkgiehdnpisryydrlatvqargtqashqipalgwed F V QGC verqeaa 3677
Cdd:cd00892 71 R TY AV I P --- L N E EC ---- GII E --------------------------------------------- W V PNT ------- 91
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3678 vlapp QV LR D I lke VQSNMV P rs M L K EW A L HT FP NA T DYWTF R KMF T IQL A LIGFAEFV L H L ------ N R L npemlqiaq 3751
Cdd:cd00892 92 ----- VT LR S I --- LSTLYP P -- V L H EW F L KN FP DP T AWYEA R NNY T RST A VMSMVGYI L G L gdrhge N I L --------- 152
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3752 dtgklnvayfrfd INDA TGD L --- D AN ---------- R P -- VPFRLT P N ISEFLTTI GV S G PLTASMIAVS R CFAQPNFK 3816
Cdd:cd00892 153 ------------- FDST TGD V vhv D FD clfdkgltle V P er VPFRLT Q N MVDAMGVT GV E G TFRRTCEVTL R VLRENRET 219
330
....*....|....*...
gi 1958668068 3817 VDGI L K T VLR D EIIA W HK 3834
Cdd:cd00892 220 LMSV L E T FVH D PLVE W SR 237
PIKKc_SMG1
cd05170 Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1; SMG-1 plays a critical ...
3521-3806
3.51e-07
Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1; SMG-1 plays a critical role in the mRNA surveillance mechanism known as non-sense mediated mRNA decay (NMD). NMD protects the cells from the accumulation of aberrant mRNAs with premature termination codons (PTCs) generated by genome mutations and by errors during transcription and splicing. SMG-1 phosphorylates Upf1, another central component of NMD, at the C-terminus upon recognition of PTCs. The phosphorylation/dephosphorylation cycle of Upf1 is essential for promoting NMD. In addition to its catalytic domain, SMG-1 contains a FATC (FRAP, ATM and TRRAP, C-terminal) domain at the C-terminus. SMG-1 is a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain, similar to that of lipid PI3K, and their large molecular weight (240-470 kDa). The SMG-1 catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and RIO kinases.
Pssm-ID: 270714
Cd Length: 304
Bit Score: 55.34
E-value: 3.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3521 I ARFMPR V EIVQK h N T AARR L YIR G HN GK I YPYL V -- MN D A cltes RRE ER VL Q L L RLL N PC L EKRK E TTK R HLFFTVPR 3598
Cdd:cd05170 1 I QSVGST V TVLPT - K T KPKK L VFL G SD GK R YPYL F kg LE D L ----- HLD ER IM Q F L SIV N AM L ASDN E HRR R RYRARHYS 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3599 V VAVS P QMR L VEDNPSSLS L VEI YK qrcakkgiehdnpis R YYD R L A TV QA RGT Q A S HQ ---------------- I PAL G 3662
Cdd:cd05170 75 V TPLG P RSG L IQWVDGATP L FSL YK --------------- R WQQ R R A AA QA QKN Q D S GS tpppvprpselfynkl K PAL K 139
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3663 w EDFVQGCVE R Q E aavl A P PQ VLR DI L K E VQSN m V PR SM L - K E - W A lh TF P NATDY W TFRKM F TIQ LA LIGFAEFVL --- 3737
Cdd:cd05170 140 - AAGIRKSTS R R E ---- W P LE VLR QV L E E LVAE - T PR DL L a R E l W C -- SS P SSAEW W RVTQR F ARS LA VMSMIGYII glg 211
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3738 -- HL N rlnpemlqiaqdtgkl N VA yfrfd INDA TG DL --- D A N ------------ RP VPFRLT P NI SEF L TTI GV S G PLT 3800
Cdd:cd05170 212 dr HL D ---------------- N IL ----- VDLS TG EV vhi D Y N vcfekgkrlrvp EK VPFRLT Q NI EHA L GPT GV E G TFR 270
....*.
gi 1958668068 3801 A S MIA V 3806
Cdd:cd05170 271 L S CEQ V 276
PIKKc_TOR
cd05169 Catalytic domain of Target of Rapamycin; TOR contains a rapamycin binding domain, a catalytic ...
3521-3783
3.87e-07
Catalytic domain of Target of Rapamycin; TOR contains a rapamycin binding domain, a catalytic domain, and a FATC (FRAP, ATM and TRRAP, C-terminal) domain at the C-terminus. It is also called FRAP (FK506 binding protein 12-rapamycin associated protein). TOR is a central component of the eukaryotic growth regulatory network. It controls the expression of many genes transcribed by all three RNA polymerases. It associates with other proteins to form two distinct complexes, TORC1 and TORC2. TORC1 is involved in diverse growth-related functions including protein synthesis, nutrient use and transport, autophagy and stress responses. TORC2 is involved in organizing cytoskeletal structures. TOR is a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain, similar to that of lipid PI3K, and their large molecular weight (240-470 kDa). The TOR catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and RIO kinases.
Pssm-ID: 270713 [Multi-domain]
Cd Length: 279
Bit Score: 54.80
E-value: 3.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3521 I AR F M P RV E IV -- QKH nta A R R L Y I R G HN GK I Y PY L VMNDAC L tes R RE ERV L QL LR L L N PC L EKRK ET TK R H L FFTVPR 3598
Cdd:cd05169 1 I SS F D P TL E VI ts KQR --- P R K L T I V G SD GK E Y KF L LKGHED L --- R LD ERV M QL FG L V N TL L KNDS ET SR R N L SIQRYS 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3599 V VAV SP QMR L VE -- DNPSS L - SL VEI Y - KQ R CAKKG IEH DNPISRY -- YD R L ATV Q argtqashqipalgwedfvqgcve 3672
Cdd:cd05169 75 V IPL SP NSG L IG wv PGCDT L h SL IRD Y r EK R KIPLN IEH RLMLQMA pd YD N L TLI Q ------------------------ 130
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3673 RQ E aavlappq V LRDI L KEVQSNMVP R SM - LK E walhtf P NATDYWTF R KM FT IQ LA LIGFAEFV L ----- H LNRL npe M 3746
Cdd:cd05169 131 KV E -------- V FEYA L ENTPGDDLR R VL w LK S ------ P SSEAWLER R TN FT RS LA VMSMVGYI L glgdr H PSNI --- M 193
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1958668068 3747 L Q ia QD TGK ln V AYFR F dindat GD L --- DAN R P ----- VPFRLT 3783
Cdd:cd05169 194 L D -- RL TGK -- V IHID F ------ GD C fev AMH R E kfpek VPFRLT 228
PIKKc_DNA-PK
cd05172 Catalytic domain of DNA-dependent protein kinase; DNA-PK is comprised of a regulatory subunit, ...
3521-3834
1.40e-04
Catalytic domain of DNA-dependent protein kinase; DNA-PK is comprised of a regulatory subunit, containing the Ku70/80 subunit, and a catalytic subunit, which contains a NUC194 domain of unknown function, a FAT (FRAP, ATM and TRRAP) domain, a catalytic domain, and a FATC domain at the C-terminus. It is part of a multi-component system involved in non-homologous end joining (NHEJ), a process of repairing double strand breaks (DSBs) by joining together two free DNA ends of little homology. DNA-PK functions as a molecular sensor for DNA damage that enhances the signal via phosphorylation of downstream targets. It may also act as a protein scaffold that aids the localization of DNA repair proteins to the site of DNA damage. DNA-PK also plays a role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. DNA-PK is a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain, similar to that of lipid PI3K, and their large molecular weight (240-470 kDa). The DNA-PK catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and RIO kinases.
Pssm-ID: 270716 [Multi-domain]
Cd Length: 235
Bit Score: 46.41
E-value: 1.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3521 I AR F M PRV EI --- VQK hnta AR R LY IRG HNG K I Y PY LV MNDAC L tes R REE R VL QL LRLL N PC L EKRKETTK R H L FFTVP 3597
Cdd:cd05172 1 I VG F D PRV LV lss KRR ---- PK R IT IRG SDE K E Y KF LV KGGED L --- R QDQ R IQ QL FDVM N NI L ASDPACRQ R R L RIRTY 73
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3598 R V VAVSPQMR L V E DNPSSLS L V EI ykqrcakkgiehdnpisryydrlatvqargtqashqipalgwedfvqgcverqeaa 3677
Cdd:cd05172 74 Q V IPMTSRLG L I E WVDNTTP L K EI -------------------------------------------------------- 97
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3678 vlappq VLR D I L KEVQSNMV prsmlkewalhtf PNATDYWTF R KM F TIQ LA LIGFAEFV L ----- HL NRL npe MLQIA qd 3752
Cdd:cd05172 98 ------ LEN D L L RRALLSLA ------------- SSPEAFLAL R SN F ARS LA AMSICGYI L gigdr HL SNF --- LVDLS -- 153
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668068 3753 TG K L NVAY F RFDIND AT GD L DANRP VPFRLT PNISEF L TTIGVS G P L TAS M IA V S R CFAQPNFKVDGILKTVLRDEIIA W 3832
Cdd:cd05172 154 TG R L IGID F GHAFGS AT QF L PIPEL VPFRLT RQLLNL L QPLDAR G L L RSD M VH V L R ALRAGRDLLLATMDVFVKEPLLD W 233
..
gi 1958668068 3833 H K 3834
Cdd:cd05172 234 Q K 235
FATC
pfam02260 FATC domain; The FATC domain is named after FRAP, ATM, TRRAP C-terminal. The solution ...
3883-3910
9.96e-04
FATC domain; The FATC domain is named after FRAP, ATM, TRRAP C-terminal. The solution structure of the FATC domain suggests it plays a role in redox-dependent structural and cellular stability.
Pssm-ID: 460514 [Multi-domain]
Cd Length: 32
Bit Score: 38.90
E-value: 9.96e-04
10 20
....*....|....*....|....*...
gi 1958668068 3883 E SK V NT L VAA A NSLD NL CR M DPA W H PW L 3910
Cdd:pfam02260 5 E GQ V DE L IQE A TDPE NL AQ M YIG W C PW W 32
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
