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Conserved domains on  [gi|1958667721|ref|XP_038944944|]
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cohesin subunit SA-3 isoform X1 [Rattus norvegicus]

Protein Classification

STAG domain-containing protein( domain architecture ID 18112794)

STAG domain-containing protein may be a subunit of a cohesin complex - a protein complex required for sister chromatid cohesion in eukaryotes

Gene Ontology:  GO:0051301|GO:0007062

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
STAG pfam08514
STAG domain; STAG domain proteins are subunits of cohesin complex - a protein complex required ...
188-301 1.71e-42

STAG domain; STAG domain proteins are subunits of cohesin complex - a protein complex required for sister chromatid cohesion in eukaryotes. The STAG domain is present in Schizosaccharomyces pombe mitotic cohesin Psc3, and the meiosis specific cohesin Rec11. Many organizms express a meiosis-specific STAG protein, for example, mice and humans have a meiosis specific variant called STAG3, although budding yeast does not have a meiosis specific version.


:

Pssm-ID: 462502  Cd Length: 113  Bit Score: 150.79  E-value: 1.71e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667721  188 GDYPLTAPGPSWKKFQGSFCEFVKTLVCQC-QYSLLFDGFPMDDLISLLIGLSDSQVRAFRHTSTLAAMKLMTSLVKVAL 266
Cdd:pfam08514    1 TEYPLISKGKKFKKFRENLCEFFSALVEQChESSLLYDEYLMENIQSWLSAMSSSKLRPFRHTATLVALALMTALCDVAA 80
                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1958667721  267 QLSLHKDNNQRQYEAERNKGPEQRapERLESLLEK 301
Cdd:pfam08514   81 ELSKSLETTQRQLEAEKKKKRANK--ERLESLEKK 113
IRR1 super family cl44256
Cohesin [Cell division and chromosome partitioning];
102-426 2.51e-26

Cohesin [Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5537:

Pssm-ID: 227824 [Multi-domain]  Cd Length: 740  Bit Score: 116.53  E-value: 2.51e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667721  102 GNDKNKSVPPTSDlFDAVKAARSCAQS-----LVDEWLENYKQDENAGFLELVNFFIRACGCKSTV----------TPEM 166
Cdd:COG5537     69 GSCPFDVFEPDAL-FSRLFFYELLDEDvireiLSVHWFEDYMKNLSKFLNSLINFDLSCCGCLTRVgnfdvqdydsTYET 147
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667721  167 -------FKTMSNSEIIQHL-TEEFNEDSGDYpltapgpsWKKFQ-GSFC-EFVKTLVCQCQyslLFDGFPMDDLISLLI 236
Cdd:COG5537    148 lgqiqlsILRGKGFEVVLYLyDENFKVRFRDV--------YQDFNiRALLvEFVSEWVVSVG---IFNSSCYLDYIGWAL 216
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667721  237 GLSDSQVRAFRHTSTLAAMKLMTSLVKVALQLSlhkdnnqrqyeaERNKGPEQRAPERLESLLekrkefqenqeeIEGMM 316
Cdd:COG5537    217 SMSNSTVRCFRHTATSCCRLIQKKLCVQAFSLS------------EKKSRMNELALYDLNPSL------------IRDEI 272
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667721  317 NAIFRGVFVHRYRDILPEIRAVCIEEIGCWMQSYSTSFLNDSYLKYIGWTLHDKHKEVRLKCVKALAGLYSNQELSSRME 396
Cdd:COG5537    273 KDICDSVFVSRYIDVDDVIRVLCSMSLRDWIGLVPDYFRKILGLRYNGWSLSDNHEGVRLLVSKILLFLCSRIPHTDAIR 352
                          330       340       350
                   ....*....|....*....|....*....|
gi 1958667721  397 LFTNRFKDRMVSMVMDRESEVAVEAIRLLT 426
Cdd:COG5537    353 RFVERFKDRILEFLRTDSDCVRICSIKSLC 382
 
Name Accession Description Interval E-value
STAG pfam08514
STAG domain; STAG domain proteins are subunits of cohesin complex - a protein complex required ...
188-301 1.71e-42

STAG domain; STAG domain proteins are subunits of cohesin complex - a protein complex required for sister chromatid cohesion in eukaryotes. The STAG domain is present in Schizosaccharomyces pombe mitotic cohesin Psc3, and the meiosis specific cohesin Rec11. Many organizms express a meiosis-specific STAG protein, for example, mice and humans have a meiosis specific variant called STAG3, although budding yeast does not have a meiosis specific version.


Pssm-ID: 462502  Cd Length: 113  Bit Score: 150.79  E-value: 1.71e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667721  188 GDYPLTAPGPSWKKFQGSFCEFVKTLVCQC-QYSLLFDGFPMDDLISLLIGLSDSQVRAFRHTSTLAAMKLMTSLVKVAL 266
Cdd:pfam08514    1 TEYPLISKGKKFKKFRENLCEFFSALVEQChESSLLYDEYLMENIQSWLSAMSSSKLRPFRHTATLVALALMTALCDVAA 80
                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1958667721  267 QLSLHKDNNQRQYEAERNKGPEQRapERLESLLEK 301
Cdd:pfam08514   81 ELSKSLETTQRQLEAEKKKKRANK--ERLESLEKK 113
IRR1 COG5537
Cohesin [Cell division and chromosome partitioning];
102-426 2.51e-26

Cohesin [Cell division and chromosome partitioning];


Pssm-ID: 227824 [Multi-domain]  Cd Length: 740  Bit Score: 116.53  E-value: 2.51e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667721  102 GNDKNKSVPPTSDlFDAVKAARSCAQS-----LVDEWLENYKQDENAGFLELVNFFIRACGCKSTV----------TPEM 166
Cdd:COG5537     69 GSCPFDVFEPDAL-FSRLFFYELLDEDvireiLSVHWFEDYMKNLSKFLNSLINFDLSCCGCLTRVgnfdvqdydsTYET 147
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667721  167 -------FKTMSNSEIIQHL-TEEFNEDSGDYpltapgpsWKKFQ-GSFC-EFVKTLVCQCQyslLFDGFPMDDLISLLI 236
Cdd:COG5537    148 lgqiqlsILRGKGFEVVLYLyDENFKVRFRDV--------YQDFNiRALLvEFVSEWVVSVG---IFNSSCYLDYIGWAL 216
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667721  237 GLSDSQVRAFRHTSTLAAMKLMTSLVKVALQLSlhkdnnqrqyeaERNKGPEQRAPERLESLLekrkefqenqeeIEGMM 316
Cdd:COG5537    217 SMSNSTVRCFRHTATSCCRLIQKKLCVQAFSLS------------EKKSRMNELALYDLNPSL------------IRDEI 272
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667721  317 NAIFRGVFVHRYRDILPEIRAVCIEEIGCWMQSYSTSFLNDSYLKYIGWTLHDKHKEVRLKCVKALAGLYSNQELSSRME 396
Cdd:COG5537    273 KDICDSVFVSRYIDVDDVIRVLCSMSLRDWIGLVPDYFRKILGLRYNGWSLSDNHEGVRLLVSKILLFLCSRIPHTDAIR 352
                          330       340       350
                   ....*....|....*....|....*....|
gi 1958667721  397 LFTNRFKDRMVSMVMDRESEVAVEAIRLLT 426
Cdd:COG5537    353 RFVERFKDRILEFLRTDSDCVRICSIKSLC 382
PDS5 pfam20168
Sister chromatid cohesion protein PDS5 protein; This entry represents the Sister chromatid ...
324-452 4.89e-03

Sister chromatid cohesion protein PDS5 protein; This entry represents the Sister chromatid cohesion protein PDS5. The large PDS5 molecule is exclusively alpha helical, composed of a large number of HEAT-like repeats and helical extensions/additions that deviate from the HEAT repeat pattern.


Pssm-ID: 466319 [Multi-domain]  Cd Length: 1051  Bit Score: 41.42  E-value: 4.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667721  324 FVHRYRDILPEIRAVCIEEIG-CWMqsySTSFLNDSYLKYIGWTLHDKHKEVRLKCVKALAGL-YSNQELSSRMELFtNR 401
Cdd:pfam20168  289 WLGRFNDKSVAVRIAWVEAAKqILL---NHPDLRSEILEALKDRLLDPDEKVRLAAVKAIGDLdYETLLHVVSEKLL-KT 364
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958667721  402 FKDRMvsmvMDRESEVAVEAIRLLTLI-----LKNMEGVLTSADC-----EKIYSIVYISN 452
Cdd:pfam20168  365 LAERL----RDKKPSVRKEALKTLAKLynvayGEIEEGDEEAIEKfgwipNKILHLYYIND 421
 
Name Accession Description Interval E-value
STAG pfam08514
STAG domain; STAG domain proteins are subunits of cohesin complex - a protein complex required ...
188-301 1.71e-42

STAG domain; STAG domain proteins are subunits of cohesin complex - a protein complex required for sister chromatid cohesion in eukaryotes. The STAG domain is present in Schizosaccharomyces pombe mitotic cohesin Psc3, and the meiosis specific cohesin Rec11. Many organizms express a meiosis-specific STAG protein, for example, mice and humans have a meiosis specific variant called STAG3, although budding yeast does not have a meiosis specific version.


Pssm-ID: 462502  Cd Length: 113  Bit Score: 150.79  E-value: 1.71e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667721  188 GDYPLTAPGPSWKKFQGSFCEFVKTLVCQC-QYSLLFDGFPMDDLISLLIGLSDSQVRAFRHTSTLAAMKLMTSLVKVAL 266
Cdd:pfam08514    1 TEYPLISKGKKFKKFRENLCEFFSALVEQChESSLLYDEYLMENIQSWLSAMSSSKLRPFRHTATLVALALMTALCDVAA 80
                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1958667721  267 QLSLHKDNNQRQYEAERNKGPEQRapERLESLLEK 301
Cdd:pfam08514   81 ELSKSLETTQRQLEAEKKKKRANK--ERLESLEKK 113
IRR1 COG5537
Cohesin [Cell division and chromosome partitioning];
102-426 2.51e-26

Cohesin [Cell division and chromosome partitioning];


Pssm-ID: 227824 [Multi-domain]  Cd Length: 740  Bit Score: 116.53  E-value: 2.51e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667721  102 GNDKNKSVPPTSDlFDAVKAARSCAQS-----LVDEWLENYKQDENAGFLELVNFFIRACGCKSTV----------TPEM 166
Cdd:COG5537     69 GSCPFDVFEPDAL-FSRLFFYELLDEDvireiLSVHWFEDYMKNLSKFLNSLINFDLSCCGCLTRVgnfdvqdydsTYET 147
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667721  167 -------FKTMSNSEIIQHL-TEEFNEDSGDYpltapgpsWKKFQ-GSFC-EFVKTLVCQCQyslLFDGFPMDDLISLLI 236
Cdd:COG5537    148 lgqiqlsILRGKGFEVVLYLyDENFKVRFRDV--------YQDFNiRALLvEFVSEWVVSVG---IFNSSCYLDYIGWAL 216
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667721  237 GLSDSQVRAFRHTSTLAAMKLMTSLVKVALQLSlhkdnnqrqyeaERNKGPEQRAPERLESLLekrkefqenqeeIEGMM 316
Cdd:COG5537    217 SMSNSTVRCFRHTATSCCRLIQKKLCVQAFSLS------------EKKSRMNELALYDLNPSL------------IRDEI 272
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667721  317 NAIFRGVFVHRYRDILPEIRAVCIEEIGCWMQSYSTSFLNDSYLKYIGWTLHDKHKEVRLKCVKALAGLYSNQELSSRME 396
Cdd:COG5537    273 KDICDSVFVSRYIDVDDVIRVLCSMSLRDWIGLVPDYFRKILGLRYNGWSLSDNHEGVRLLVSKILLFLCSRIPHTDAIR 352
                          330       340       350
                   ....*....|....*....|....*....|
gi 1958667721  397 LFTNRFKDRMVSMVMDRESEVAVEAIRLLT 426
Cdd:COG5537    353 RFVERFKDRILEFLRTDSDCVRICSIKSLC 382
PDS5 pfam20168
Sister chromatid cohesion protein PDS5 protein; This entry represents the Sister chromatid ...
324-452 4.89e-03

Sister chromatid cohesion protein PDS5 protein; This entry represents the Sister chromatid cohesion protein PDS5. The large PDS5 molecule is exclusively alpha helical, composed of a large number of HEAT-like repeats and helical extensions/additions that deviate from the HEAT repeat pattern.


Pssm-ID: 466319 [Multi-domain]  Cd Length: 1051  Bit Score: 41.42  E-value: 4.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958667721  324 FVHRYRDILPEIRAVCIEEIG-CWMqsySTSFLNDSYLKYIGWTLHDKHKEVRLKCVKALAGL-YSNQELSSRMELFtNR 401
Cdd:pfam20168  289 WLGRFNDKSVAVRIAWVEAAKqILL---NHPDLRSEILEALKDRLLDPDEKVRLAAVKAIGDLdYETLLHVVSEKLL-KT 364
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958667721  402 FKDRMvsmvMDRESEVAVEAIRLLTLI-----LKNMEGVLTSADC-----EKIYSIVYISN 452
Cdd:pfam20168  365 LAERL----RDKKPSVRKEALKTLAKLynvayGEIEEGDEEAIEKfgwipNKILHLYYIND 421
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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