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Conserved domains on  [gi|1958665573|ref|XP_038944300|]
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centrosomal protein of 97 kDa isoform X3 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 18-242 1.18e-22

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 96.39  E-value: 1.18e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665573  18 VNWSGQGLQKLGANLPCdADVHTLILDKNQIIKLENLEKCKQLIQLSVANNRLVRMMGVAKLTQLRVLNLPHNSIGCMEG 97
Cdd:cd21340     7 LYLNDKNITKIDNLSLC-KNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEG 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665573  98 LKDLVHLEWLNLAGNNLKTMEQ-------INSCSA-LQHLDLSDNNIPQIGDVskltalktlllhgniitslrmapAYLp 169
Cdd:cd21340    86 LENLTNLEELHIENQRLPPGEKltfdprsLAALSNsLRVLNISGNNIDSLEPL-----------------------APL- 141

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958665573 170 RNLSILSLAENEIRDLNEIS-FLASLSELEQLSIMNNPcVMATPSipgfdYRPYIVSWCLNLRVLDGYVISQKE 242
Cdd:cd21340   142 RNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNP-VCKKPK-----YRDKIILASKSLEVLDGKEITDTE 209
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 540-560 2.12e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


:

Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 38.68  E-value: 2.12e-04
                          10        20
                  ....*....|....*....|.
gi 1958665573 540 LQKLNAAATKLQACWRGFYTR 560
Cdd:cd23767     5 LQRMNRAATLIQALWRGYKVR 25
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 18-242 1.18e-22

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 96.39  E-value: 1.18e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665573  18 VNWSGQGLQKLGANLPCdADVHTLILDKNQIIKLENLEKCKQLIQLSVANNRLVRMMGVAKLTQLRVLNLPHNSIGCMEG 97
Cdd:cd21340     7 LYLNDKNITKIDNLSLC-KNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEG 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665573  98 LKDLVHLEWLNLAGNNLKTMEQ-------INSCSA-LQHLDLSDNNIPQIGDVskltalktlllhgniitslrmapAYLp 169
Cdd:cd21340    86 LENLTNLEELHIENQRLPPGEKltfdprsLAALSNsLRVLNISGNNIDSLEPL-----------------------APL- 141

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958665573 170 RNLSILSLAENEIRDLNEIS-FLASLSELEQLSIMNNPcVMATPSipgfdYRPYIVSWCLNLRVLDGYVISQKE 242
Cdd:cd21340   142 RNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNP-VCKKPK-----YRDKIILASKSLEVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-206 8.08e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.90  E-value: 8.08e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665573  40 TLILDKNQIIKL-ENLEKCKQLIQLSVANNRLVRM-MGVAKLTQLRVLNLPHNSIGCM-EGLKDLVHLEWLNLAGNNLKT 116
Cdd:COG4886   163 SLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTD 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665573 117 MEQINSCSALQHLDLSDNNIPQIGDVSKLTALKTLLLHGNIITSLRMAPAYLPRNLSILSLAENEIRDLNEISFLASLSE 196
Cdd:COG4886   243 LPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTT 322

                         170
                  ....*....|
gi 1958665573 197 LEQLSIMNNP 206
Cdd:COG4886   323 LLLLLLLLKG 332
LRR_9 pfam14580
Leucine-rich repeat;
107-256 1.37e-07

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 51.69  E-value: 1.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665573 107 LNLAGNNLKTMEQIN-SCSALQHLDLSDNNIPQIGDVSKLTALKTLLLHGNIItsLRMAPA---YLPrNLSILSLAENEI 182
Cdd:pfam14580  24 LDLRGYKIPIIENLGaTLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRI--CRIGEGlgeALP-NLTELILTNNNL 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958665573 183 RDLNEISFLASLSELEQLSIMNNPcVMATPsipgfDYRPYIVSWCLNLRVLDGYVISQKESLKAEWLYSQGKGR 256
Cdd:pfam14580 101 QELGDLDPLASLKKLTFLSLLRNP-VTNKP-----HYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGK 168
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
24-187 1.30e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.62  E-value: 1.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665573  24 GLQKLGANLPcdADVHTLILDKNQIIKL-ENLEKckQLIQLSVANNRLVRM-------MGVAKLTQLRVLNLP------- 88
Cdd:PRK15370  189 GLTTIPACIP--EQITTLILDNNELKSLpENLQG--NIKTLYANSNQLTSIpatlpdtIQEMELSINRITELPerlpsal 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665573  89 ------HNSIGCM-EGLKDlvHLEWLNLAGNNLKTMEQiNSCSALQHLDLSDNNIPQIGDvSKLTALKTLLLHGNIITSL 161
Cdd:PRK15370  265 qsldlfHNKISCLpENLPE--ELRYLSVYDNSIRTLPA-HLPSGITHLNVQSNSLTALPE-TLPPGLKTLEAGENALTSL 340

                         170       180
                  ....*....|....*....|....*.
gi 1958665573 162 rmaPAYLPRNLSILSLAENEIRDLNE 187
Cdd:PRK15370  341 ---PASLPPELQVLDVSKNQITVLPE 363
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 540-560 2.12e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 38.68  E-value: 2.12e-04
                          10        20
                  ....*....|....*....|.
gi 1958665573 540 LQKLNAAATKLQACWRGFYTR 560
Cdd:cd23767     5 LQRMNRAATLIQALWRGYKVR 25
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 18-242 1.18e-22

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 96.39  E-value: 1.18e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665573  18 VNWSGQGLQKLGANLPCdADVHTLILDKNQIIKLENLEKCKQLIQLSVANNRLVRMMGVAKLTQLRVLNLPHNSIGCMEG 97
Cdd:cd21340     7 LYLNDKNITKIDNLSLC-KNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEG 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665573  98 LKDLVHLEWLNLAGNNLKTMEQ-------INSCSA-LQHLDLSDNNIPQIGDVskltalktlllhgniitslrmapAYLp 169
Cdd:cd21340    86 LENLTNLEELHIENQRLPPGEKltfdprsLAALSNsLRVLNISGNNIDSLEPL-----------------------APL- 141

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958665573 170 RNLSILSLAENEIRDLNEIS-FLASLSELEQLSIMNNPcVMATPSipgfdYRPYIVSWCLNLRVLDGYVISQKE 242
Cdd:cd21340   142 RNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNP-VCKKPK-----YRDKIILASKSLEVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-206 8.08e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.90  E-value: 8.08e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665573  40 TLILDKNQIIKL-ENLEKCKQLIQLSVANNRLVRM-MGVAKLTQLRVLNLPHNSIGCM-EGLKDLVHLEWLNLAGNNLKT 116
Cdd:COG4886   163 SLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTD 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665573 117 MEQINSCSALQHLDLSDNNIPQIGDVSKLTALKTLLLHGNIITSLRMAPAYLPRNLSILSLAENEIRDLNEISFLASLSE 196
Cdd:COG4886   243 LPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTT 322

                         170
                  ....*....|
gi 1958665573 197 LEQLSIMNNP 206
Cdd:COG4886   323 LLLLLLLLKG 332
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-208 1.31e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 1.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665573  40 TLILDKNQIIKL-ENLEKCKQLIQLSVANNRLVRM-MGVAKLTQLRVLNLPHNSIGCMEGLKDLVHLEWLNLAGNNLKTM 117
Cdd:COG4886   186 ELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDL 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665573 118 EQINSCSALQHLDLSDNNIPQIGDVSKLTALKTLLLHGNIITSLRMAPAYLPRNLSILSLAENEIRDLNEISFLASLSEL 197
Cdd:COG4886   266 PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLS 345

                         170
                  ....*....|.
gi 1958665573 198 EQLSIMNNPCV 208
Cdd:COG4886   346 LLALLTLLLLL 356
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
35-205 2.07e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.03  E-value: 2.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665573  35 DADVHTLILDKNQIIKLENLEKCKQLIQLSVANNRLVRMMGVAKLTQLRVLNLPHNsigcmEGLKDLVHLEWLNLAGNNL 114
Cdd:COG4886    51 LLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQL 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665573 115 KTM-EQINSCSALQHLDLSDNNIPQIGDV-SKLTALKTLLLHGNIITSLRMAPAYLPrNLSILSLAENEIRDLNEisFLA 192
Cdd:COG4886   126 TDLpEELANLTNLKELDLSNNQLTDLPEPlGNLTNLKSLDLSNNQLTDLPEELGNLT-NLKELDLSNNQITDLPE--PLG 202

                         170
                  ....*....|...
gi 1958665573 193 SLSELEQLSIMNN 205
Cdd:COG4886   203 NLTNLEELDLSGN 215
LRR_9 pfam14580
Leucine-rich repeat;
107-256 1.37e-07

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 51.69  E-value: 1.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665573 107 LNLAGNNLKTMEQIN-SCSALQHLDLSDNNIPQIGDVSKLTALKTLLLHGNIItsLRMAPA---YLPrNLSILSLAENEI 182
Cdd:pfam14580  24 LDLRGYKIPIIENLGaTLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRI--CRIGEGlgeALP-NLTELILTNNNL 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958665573 183 RDLNEISFLASLSELEQLSIMNNPcVMATPsipgfDYRPYIVSWCLNLRVLDGYVISQKESLKAEWLYSQGKGR 256
Cdd:pfam14580 101 QELGDLDPLASLKKLTFLSLLRNP-VTNKP-----HYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGK 168
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
24-187 1.30e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.62  E-value: 1.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665573  24 GLQKLGANLPcdADVHTLILDKNQIIKL-ENLEKckQLIQLSVANNRLVRM-------MGVAKLTQLRVLNLP------- 88
Cdd:PRK15370  189 GLTTIPACIP--EQITTLILDNNELKSLpENLQG--NIKTLYANSNQLTSIpatlpdtIQEMELSINRITELPerlpsal 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665573  89 ------HNSIGCM-EGLKDlvHLEWLNLAGNNLKTMEQiNSCSALQHLDLSDNNIPQIGDvSKLTALKTLLLHGNIITSL 161
Cdd:PRK15370  265 qsldlfHNKISCLpENLPE--ELRYLSVYDNSIRTLPA-HLPSGITHLNVQSNSLTALPE-TLPPGLKTLEAGENALTSL 340

                         170       180
                  ....*....|....*....|....*.
gi 1958665573 162 rmaPAYLPRNLSILSLAENEIRDLNE 187
Cdd:PRK15370  341 ---PASLPPELQVLDVSKNQITVLPE 363
LRR_8 pfam13855
Leucine rich repeat;
80-136 3.04e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 3.04e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958665573  80 TQLRVLNLPHNSIG--CMEGLKDLVHLEWLNLAGNNLKTMEQ--INSCSALQHLDLSDNNI 136
Cdd:pfam13855   1 PNLRSLDLSNNRLTslDDGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 23-204 1.98e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 47.48  E-value: 1.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665573  23 QGLQKLGANLPCDADVHTLILDKNQI------IKLENLEKCKQLIQLSVANNRLVR--MMGVAKL----TQLRVLNLPHN 90
Cdd:COG5238   195 EGIEELAEALTQNTTVTTLWLKRNPIgdegaeILAEALKGNKSLTTLDLSNNQIGDegVIALAEAlknnTTVETLYLSGN 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665573  91 SIGC------MEGLKDLVHLEWLNLAGNNLKTMEQINSCSALQH------LDLSDNNIPQIGDVSkltalktlllhgnII 158
Cdd:COG5238   275 QIGAegaialAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGnktlhtLNLAYNGIGAQGAIA-------------LA 341

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1958665573 159 TSLRMApaylpRNLSILSLAENEIRDLNEISFLASLSELEQLSIMN 204
Cdd:COG5238   342 KALQEN-----TTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELN 382
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-187 2.85e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.85  E-value: 2.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665573  39 HTLILDKNQIIKLENLEKCKQLIQLSVANNRLVRMMGVAKLTQLRVLNLPHNSIGCMEgLKDLVHLEWLNLAGNNLKTME 118
Cdd:COG4886   231 ETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK-LKELELLLGLNSLLLLLLLLN 309

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958665573 119 QINSCSALQHLDLSDNNIPQIGDVSKLTALKTLLLHGNIITSLRMAPAYLPRNLSILSLAENEIRDLNE 187
Cdd:COG4886   310 LLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEAT 378
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-205 1.56e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.54  E-value: 1.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665573  40 TLILDKNQIIKLENLEKCKQLIQLSVANNRLVRMMGVAKLTQLRVLNLPHNSIGCMEGLKDLVHLEWLNLAGNNLKTMEQ 119
Cdd:COG4886    12 LLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665573 120 INSCSALQHLDLSDNNipqigDVSKLTALKTLLLHGNIITSLrmaPAYLPR--NLSILSLAENEIRDLNEisFLASLSEL 197
Cdd:COG4886    92 LGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDL---PEELANltNLKELDLSNNQLTDLPE--PLGNLTNL 161


                  ....*...
gi 1958665573 198 EQLSIMNN 205
Cdd:COG4886   162 KSLDLSNN 169
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 540-560 2.12e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 38.68  E-value: 2.12e-04
                          10        20
                  ....*....|....*....|.
gi 1958665573 540 LQKLNAAATKLQACWRGFYTR 560
Cdd:cd23767     5 LQRMNRAATLIQALWRGYKVR 25
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 103-143 2.23e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 2.23e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1958665573 103 HLEWLNLAGNNLKTMEQINSCSALQHLDLSDNNipQIGDVS 143
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNN--KITDLS 40
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 23-140 5.91e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.47  E-value: 5.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665573  23 QGLQKLGANLPCDADVHTLILDKNQI-----IKL-ENLEKCKQLIQLSVANNRLvRMMGVAKLTQ-------LRVLNLPH 89
Cdd:COG5238   251 EGVIALAEALKNNTTVETLYLSGNQIgaegaIALaKALQGNTTLTSLDLSVNRI-GDEGAIALAEglqgnktLHTLNLAY 329

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958665573  90 NSIG--CMEGL----KDLVHLEWLNLAGNNLKT------MEQINSCSALQHLDLSDNNIPQIG 140
Cdd:COG5238   330 NGIGaqGAIALakalQENTTLHSLDLSDNQIGDegaialAKYLEGNTTLRELNLGKNNIGKQG 392
LRR_8 pfam13855
Leucine rich repeat;
103-143 5.04e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 5.04e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1958665573 103 HLEWLNLAGNNLKTMEQ--INSCSALQHLDLSDNNIPQIGDVS 143
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGA 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 80-114 5.88e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 5.88e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1958665573  80 TQLRVLNLPHNSIGCMEGLKDLVHLEWLNLAGNNL 114
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNK 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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