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Conserved domains on  [gi|1958665085|ref|XP_038944115|]
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transmembrane protease serine 7 isoform X8 [Rattus norvegicus]

Protein Classification

CUB and LDLa domain-containing protein( domain architecture ID 10475858)

protein containing domains SEA, CUB, and LDLa

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 94-193 7.98e-22

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


:

Pssm-ID: 460188  Cd Length: 100  Bit Score: 89.99  E-value: 7.98e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665085  94 FYFVGMFRITNIEFLPEYRQKESREFLSMAKTVQQVVNLVYTTSAFSKFYKQSVVADVsSNNKGGLLVHFWIVFVMPHAK 173
Cdd:pfam01390   1 QYYTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRNSSLRKQYIKSHVLRL-RPDGGSVVVDVVLVFRFPSTE 79

                          90       100
                  ....*....|....*....|
gi 1958665085 174 GHIFCEECVAAILKDSIQTS 193
Cdd:pfam01390  80 PALDREKLIEEILRQTLNNT 99
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 470-504 8.08e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 8.08e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1958665085 470 CPAGSFRCSSGLCVPQAQRCDGVNDCFDESDELFC 504
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 257-345 6.32e-09

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 53.96  E-value: 6.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665085 257 LMCHFKLVAIVGYLIRLSIESIQLEAD-NCITDSLTVYDSlLPIRSAILYRICEpTRTLMSFVSTNNLMLVTLKSPYVRR 335
Cdd:cd00041    26 LNCVWTIEAPPGYRIRLTFEDFDLESSpNCSYDYLEIYDG-PSTSSPLLGRFCG-STLPPPIISSGNSLTVRFRSDSSVT 103

                          90
                  ....*....|
gi 1958665085 336 LAGIRAYFEV 345
Cdd:cd00041   104 GRGFKATYSA 113
 
Name Accession Description Interval E-value
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 94-193 7.98e-22

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


Pssm-ID: 460188  Cd Length: 100  Bit Score: 89.99  E-value: 7.98e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665085  94 FYFVGMFRITNIEFLPEYRQKESREFLSMAKTVQQVVNLVYTTSAFSKFYKQSVVADVsSNNKGGLLVHFWIVFVMPHAK 173
Cdd:pfam01390   1 QYYTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRNSSLRKQYIKSHVLRL-RPDGGSVVVDVVLVFRFPSTE 79

                          90       100
                  ....*....|....*....|
gi 1958665085 174 GHIFCEECVAAILKDSIQTS 193
Cdd:pfam01390  80 PALDREKLIEEILRQTLNNT 99
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 470-504 8.08e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 8.08e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1958665085 470 CPAGSFRCSSGLCVPQAQRCDGVNDCFDESDELFC 504
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 470-501 1.25e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 59.18  E-value: 1.25e-11
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958665085  470 CPAGSFRCSSGLCVPQAQRCDGVNDCFDESDE 501
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 257-345 6.32e-09

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 53.96  E-value: 6.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665085 257 LMCHFKLVAIVGYLIRLSIESIQLEAD-NCITDSLTVYDSlLPIRSAILYRICEpTRTLMSFVSTNNLMLVTLKSPYVRR 335
Cdd:cd00041    26 LNCVWTIEAPPGYRIRLTFEDFDLESSpNCSYDYLEIYDG-PSTSSPLLGRFCG-STLPPPIISSGNSLTVRFRSDSSVT 103

                          90
                  ....*....|
gi 1958665085 336 LAGIRAYFEV 345
Cdd:cd00041   104 GRGFKATYSA 113
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
469-504 1.27e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.71  E-value: 1.27e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1958665085 469 PCPAGSFRCSSGLCVPQAQRCDGVNDCFDESDELFC 504
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 259-343 1.02e-06

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 47.38  E-value: 1.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665085  259 CHFKLVAIVGYLIRLSIESIQLEA-DNCITDSLTVYDSlLPIRSAILYRICEPTRTLMSFVSTNNLMLVTLKSPYVRRLA 337
Cdd:smart00042  18 CVWTIRAPPGYRIELQFTDFDLESsDNCEYDYVEIYDG-PSASSPLLGRFCGSEAPPPVISSSSNSLTLTFVSDSSVQKR 96


                   ....*.
gi 1958665085  338 GIRAYF 343
Cdd:smart00042  97 GFSARY 102
CUB pfam00431
CUB domain;
259-343 1.63e-03

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 38.43  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665085 259 CHFKLVAIVGYLIRLSIESIQLEA-DNCITDSLTVYDSllPIRSAILY-RICEPTRTLmSFVSTNNLMLVTLKSPYVRRL 336
Cdd:pfam00431  27 CVWLIRAPPGFRVKLTFQDFELEDhDECGYDYVEIRDG--PSASSPLLgRFCGSGIPE-DIVSSSNQMTIKFVSDASVQK 103


                  ....*..
gi 1958665085 337 AGIRAYF 343
Cdd:pfam00431 104 RGFKATY 110
 
Name Accession Description Interval E-value
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 94-193 7.98e-22

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


Pssm-ID: 460188  Cd Length: 100  Bit Score: 89.99  E-value: 7.98e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665085  94 FYFVGMFRITNIEFLPEYRQKESREFLSMAKTVQQVVNLVYTTSAFSKFYKQSVVADVsSNNKGGLLVHFWIVFVMPHAK 173
Cdd:pfam01390   1 QYYTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRNSSLRKQYIKSHVLRL-RPDGGSVVVDVVLVFRFPSTE 79

                          90       100
                  ....*....|....*....|
gi 1958665085 174 GHIFCEECVAAILKDSIQTS 193
Cdd:pfam01390  80 PALDREKLIEEILRQTLNNT 99
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 470-504 8.08e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 8.08e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1958665085 470 CPAGSFRCSSGLCVPQAQRCDGVNDCFDESDELFC 504
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 470-501 1.25e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 59.18  E-value: 1.25e-11
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958665085  470 CPAGSFRCSSGLCVPQAQRCDGVNDCFDESDE 501
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 257-345 6.32e-09

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 53.96  E-value: 6.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665085 257 LMCHFKLVAIVGYLIRLSIESIQLEAD-NCITDSLTVYDSlLPIRSAILYRICEpTRTLMSFVSTNNLMLVTLKSPYVRR 335
Cdd:cd00041    26 LNCVWTIEAPPGYRIRLTFEDFDLESSpNCSYDYLEIYDG-PSTSSPLLGRFCG-STLPPPIISSGNSLTVRFRSDSSVT 103

                          90
                  ....*....|
gi 1958665085 336 LAGIRAYFEV 345
Cdd:cd00041   104 GRGFKATYSA 113
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
469-504 1.27e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.71  E-value: 1.27e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1958665085 469 PCPAGSFRCSSGLCVPQAQRCDGVNDCFDESDELFC 504
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 259-343 1.02e-06

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 47.38  E-value: 1.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665085  259 CHFKLVAIVGYLIRLSIESIQLEA-DNCITDSLTVYDSlLPIRSAILYRICEPTRTLMSFVSTNNLMLVTLKSPYVRRLA 337
Cdd:smart00042  18 CVWTIRAPPGYRIELQFTDFDLESsDNCEYDYVEIYDG-PSASSPLLGRFCGSEAPPPVISSSSNSLTLTFVSDSSVQKR 96


                   ....*.
gi 1958665085  338 GIRAYF 343
Cdd:smart00042  97 GFSARY 102
CUB pfam00431
CUB domain;
259-343 1.63e-03

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 38.43  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665085 259 CHFKLVAIVGYLIRLSIESIQLEA-DNCITDSLTVYDSllPIRSAILY-RICEPTRTLmSFVSTNNLMLVTLKSPYVRRL 336
Cdd:pfam00431  27 CVWLIRAPPGFRVKLTFQDFELEDhDECGYDYVEIRDG--PSASSPLLgRFCGSGIPE-DIVSSSNQMTIKFVSDASVQK 103


                  ....*..
gi 1958665085 337 AGIRAYF 343
Cdd:pfam00431 104 RGFKATY 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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