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Conserved domains on  [gi|1958664623|ref|XP_038943925|]
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beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1 [Rattus norvegicus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 690)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor (CMP-NeuA) instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.99.-
Gene Ontology:  GO:0008373|GO:0006486
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 134-398 0e+00

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467713  Cd Length: 266  Bit Score: 568.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 134 VEALRCHLRDHVNVSMIEATDFPFNTTEWEGYLPKENFRTKVGPWQRCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPT 213
Cdd:cd23985     1 AEELLCELKDKVNVSMLEGTDFPFNTSEWEGYLPKKSLREEVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 214 DNFQQDVGSKTTIRLMNSQLVTTEKR-FLKDSLYTEGILIVWDPSVYHADIPKWYQKPDYNFFETYKSYRRLNPSQPFYI 292
Cdd:cd23985    81 AGFQQDVGTKTTIRLINSQLVTTEKHkFLKDSLYNEGILIVWDPAPYHSDIPEWYKNPDYNFFENYKTYRRLNPNQPFYI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 293 LKPQMPWELWDIIQEISADLIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYHQKFFDSACTMGAYHPLLFE 372
Cdd:cd23985   161 LHPQMQWELWDIIQENSPEEIQPNPPSSGMLGIILMMTLCDQVDVYEFLPSKRKTDVCHYYQKFFDRACTMGAYHPLLYE 240

                         250       260
                  ....*....|....*....|....*.
gi 1958664623 373 KNMVKHLNEGTDEDIYLFGKATLSGF 398
Cdd:cd23985   241 KNLVKHLNQGTDEDIYLLGKVTLPGF 266
 
Name Accession Description Interval E-value
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 134-398 0e+00

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 568.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 134 VEALRCHLRDHVNVSMIEATDFPFNTTEWEGYLPKENFRTKVGPWQRCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPT 213
Cdd:cd23985     1 AEELLCELKDKVNVSMLEGTDFPFNTSEWEGYLPKKSLREEVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 214 DNFQQDVGSKTTIRLMNSQLVTTEKR-FLKDSLYTEGILIVWDPSVYHADIPKWYQKPDYNFFETYKSYRRLNPSQPFYI 292
Cdd:cd23985    81 AGFQQDVGTKTTIRLINSQLVTTEKHkFLKDSLYNEGILIVWDPAPYHSDIPEWYKNPDYNFFENYKTYRRLNPNQPFYI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 293 LKPQMPWELWDIIQEISADLIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYHQKFFDSACTMGAYHPLLFE 372
Cdd:cd23985   161 LHPQMQWELWDIIQENSPEEIQPNPPSSGMLGIILMMTLCDQVDVYEFLPSKRKTDVCHYYQKFFDRACTMGAYHPLLYE 240

                         250       260
                  ....*....|....*....|....*.
gi 1958664623 373 KNMVKHLNEGTDEDIYLFGKATLSGF 398
Cdd:cd23985   241 KNLVKHLNQGTDEDIYLLGKVTLPGF 266
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 166-379 3.18e-30

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 116.94  E-value: 3.18e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 166 LPKEN-FRTKvgPWQRCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKTTIRLMN--SQLVTTEKRFLK 242
Cdd:pfam00777  32 LPKVSpFDNK--RCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNpeSAIDSKYGNLGF 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 243 DSLYTEGILIV----------WDPS-VYHADIPKWYQKpdynfFETYKSYR-RLNPSQpFYILKPqmpwelwDIIQEISA 310
Cdd:pfam00777 110 SHPRDPFVEFVlvpfkgrdllWLPAfLTKGNVSRSLRV-----LYTLKEVKiPVDPDK-VLFLHP-------DFLRYVAN 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 311 DL-----IQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSkrktdvcYYHQKF----FDSAC--TMGAY--HPLLFEKNMVK 377
Cdd:pfam00777 177 FWlrshgLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF-------LDSRGNshhyYDNVLmkKGGFYgvHDMPFEFKLLQ 249


                  ..
gi 1958664623 378 HL 379
Cdd:pfam00777 250 KL 251
 
Name Accession Description Interval E-value
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 134-398 0e+00

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 568.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 134 VEALRCHLRDHVNVSMIEATDFPFNTTEWEGYLPKENFRTKVGPWQRCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPT 213
Cdd:cd23985     1 AEELLCELKDKVNVSMLEGTDFPFNTSEWEGYLPKKSLREEVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 214 DNFQQDVGSKTTIRLMNSQLVTTEKR-FLKDSLYTEGILIVWDPSVYHADIPKWYQKPDYNFFETYKSYRRLNPSQPFYI 292
Cdd:cd23985    81 AGFQQDVGTKTTIRLINSQLVTTEKHkFLKDSLYNEGILIVWDPAPYHSDIPEWYKNPDYNFFENYKTYRRLNPNQPFYI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 293 LKPQMPWELWDIIQEISADLIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYHQKFFDSACTMGAYHPLLFE 372
Cdd:cd23985   161 LHPQMQWELWDIIQENSPEEIQPNPPSSGMLGIILMMTLCDQVDVYEFLPSKRKTDVCHYYQKFFDRACTMGAYHPLLYE 240

                         250       260
                  ....*....|....*....|....*.
gi 1958664623 373 KNMVKHLNEGTDEDIYLFGKATLSGF 398
Cdd:cd23985   241 KNLVKHLNQGTDEDIYLLGKVTLPGF 266
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 135-398 3.23e-142

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 405.50  E-value: 3.23e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 135 EALRCHLRDHVNVSMIEATDFPFNTTEWEGYLPKENFRTKVGPWQRCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTD 214
Cdd:cd23968     2 EDLLCRLKKAAPFSTLRKTTSPFKDLLSLRYPFPESSLENTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 215 NFQQDVGSKTTIRLMNSQLVT-TEKRFLKDSLYTEGILIVWDPSVYHADIPKWYQKPDYNFFETYKSYRRLNPSQPFYIL 293
Cdd:cd23968    82 GFEKDVGSKTTLRLINSQILSkPEFNFLTDPLYRNVTLLVWDPSSYNVNLEKWYKKPDFDFFPNYIKYRRRHPEEPFYLI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 294 KPQMPWELWDIIQEISADLIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYHQKFFDSACTMGAYHPLLFEK 373
Cdd:cd23968   162 DPRFLWRLWDILQEYTPEKIKPNPPSSGFIGIVLMLHLCDWVDVYEYVPSVRQTDRCHYYDVEKDLACTLGAWHPLAAEK 241

                         250       260
                  ....*....|....*....|....*
gi 1958664623 374 NMVKHLNEGTDEDIYLFGKATLSGF 398
Cdd:cd23968   242 LLVRHLNVGSDDDIFRKGRATLPGF 266
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 131-398 9.08e-124

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 358.77  E-value: 9.08e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 131 KFSVEALRCHLRDHVNVSMIEATDFPFNTTEWEGYLPKENFrTKVGP--WQRCAVVSSAGSLKNSQLGREIDNHDAVLRF 208
Cdd:cd23986     1 KLSRQELLCELKKRVQVRTLDGKEAPFSALGWEKYVPKIPL-SKLHLrgFRSCAVVTSAGAILNSSLGKEIDSHDAVLRF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 209 NGAPTDNFQQDVGSKTTIRLMNSQLVTTEK-RFLKDSLYTEGILIVWDPSVYHADIPKWYQKPDYNFFETYKSYRRLNPS 287
Cdd:cd23986    80 NSAPTRGYEKDVGNKTTIRIINSQILTNPNhHFIDSSLYKDVILVAWDPAPYSANLHKWYKKPDYNLFTPYVQYRKRNPN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 288 QPFYILKPQMPWELWDIIQEISADLIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYHQKFFDSACTMGAYH 367
Cdd:cd23986   160 QPFYILHPKFIWQLWDIIQENTQEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTDLCHYHERYYDAACTLGAYH 239

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1958664623 368 PLLFEKNMVKHLNEGTDEDIYLFGKATLSGF 398
Cdd:cd23986   240 PLLYEKLLIQRMNKGTEDDLYRKGKVILPGF 270
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 181-379 1.15e-50

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 168.70  E-value: 1.15e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 181 CAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKTTIRLMNSQLV-----TTEKRFLKDSLYTEGILIVWD 255
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAgfylrGPRCGCHPLPLEEEVVLILSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 256 PSVYhadipkwyqkpdynFFETYKSYRRLNPSQPFYILK--PQMPWELWDIIQEISADLIQ-PNPPSSGMLGIIIMMTLC 332
Cdd:cd19952    81 AAAA--------------DFKRLKRRKKRHDNAVLLLTDpaPDLLSYVRKRLEKLGLKSFFgGNAPSSGLLAVLLALQLC 146

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1958664623 333 DQVDIYEF--LPSKRKTDVCYYHQKFFDSActMGAYHPLLFEKNMVKHL 379
Cdd:cd19952   147 DSVDLYGFgvDSGHAPKVPYHYYDLVEAEE--GTAVHSFDLEAELLRAL 193
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 166-379 3.18e-30

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 116.94  E-value: 3.18e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 166 LPKEN-FRTKvgPWQRCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKTTIRLMN--SQLVTTEKRFLK 242
Cdd:pfam00777  32 LPKVSpFDNK--RCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNpeSAIDSKYGNLGF 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 243 DSLYTEGILIV----------WDPS-VYHADIPKWYQKpdynfFETYKSYR-RLNPSQpFYILKPqmpwelwDIIQEISA 310
Cdd:pfam00777 110 SHPRDPFVEFVlvpfkgrdllWLPAfLTKGNVSRSLRV-----LYTLKEVKiPVDPDK-VLFLHP-------DFLRYVAN 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 311 DL-----IQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSkrktdvcYYHQKF----FDSAC--TMGAY--HPLLFEKNMVK 377
Cdd:pfam00777 177 FWlrshgLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF-------LDSRGNshhyYDNVLmkKGGFYgvHDMPFEFKLLQ 249


                  ..
gi 1958664623 378 HL 379
Cdd:pfam00777 250 KL 251
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 165-342 2.32e-25

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 103.88  E-value: 2.32e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 165 YLPKEN-FRTKvgPWQRCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKT--------TIRLMNSQLVT 235
Cdd:cd23963    51 LLPKTSpFSHK--RYKTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTnlttlnpsILKRRYNSLKK 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 236 TE--KRFLKD-SLYTEGILivwdpsVYHADIPKWYQKPdynFFETYKSYRRLNPSQPFYILKPQMP---WELWdiiqeis 309
Cdd:cd23963   129 NRdrDKFLNRlKEYNGSIL------WYPKFSFKSSTNL---LLKAARALKKNGLNLTVVYSNPEHFlavQKFW------- 192

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1958664623 310 ADLIQPNPPSSGMLGIIIMMTLCDQVDIYEFLP 342
Cdd:cd23963   193 KRRGLEKRPSTGLYLVSLALTFCDEIHLYGFWP 225
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 179-367 1.34e-24

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 100.78  E-value: 1.34e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 179 QRCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKTTIRLM---NSQLVTTEKRFLKDSLYTEGILIVWD 255
Cdd:cd23965     2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVshsSLPRLLRNAILLLAGTRAPTVVVFWG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 256 PSVYhadipkwYQKPDYNFFETYKSYRRLNPSQPFYILKPQMpwelwdiiqEISADLIQPNPP-----------SSGMLG 324
Cdd:cd23965    82 PETK-------MNKDGAGKYNLLRSLSKKYPDVEFYSLTPEK---------MDYADELFEKETgksriksgtwlSTGWFT 145

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1958664623 325 IIIMMTLCDQVDIYEFLPSK-----RKTDVCY-YHQKFFDSACTMGAYH 367
Cdd:cd23965   146 MLLALDVCDEIKVYGMVPENycrehPNSKVPYhYYEPGGLKECTYYNYH 194
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 180-379 1.90e-24

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 99.67  E-value: 1.90e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 180 RCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKTTIRlmnsqLVTTEKRFLKDSLYTEGILIVWDPsvY 259
Cdd:cd23967     4 RCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFR-----MFYPESAFRDPEEYDSDWLLVLVP--F 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 260 HADIPKWYQ------KPDYNFFETYKSYRRL--NPSQpFYILKPQmpwelwdIIQEISADLIQ--------PNPPSSGML 323
Cdd:cd23967    77 KSMDLLWLQavikgkKPNGKGGFWKKIATSVpkPPKK-IRILNPY-------ILQEAAFDLIGlpmngkqgKNVPTTGII 148

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958664623 324 GIIIMMTLCDQVDI--YEFLPSKRKTDVCYYhqkffDSACT----MGAYHPLLFEKNMVKHL 379
Cdd:cd23967   149 AIVMALHYCDEVDIagFGYDPSDPNAPLHYY-----DSLTMkaikRSWTHNVTKEKKYLKKL 205
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 179-379 2.81e-19

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 85.49  E-value: 2.81e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 179 QRCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKTTIRLM--NSQLVTTEKRFLKDSLYtegILIVWDP 256
Cdd:cd23982     3 RRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFypESAQFDPGIENDPDTLL---VLVPFKP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 257 SVYHadipkW-------YQKPDYNFFETYKSYRRLNPSQpFYILKPQMPWELWDIIQEISADLIQPNPPSSGMLGIIIMM 329
Cdd:cd23982    80 LDFY-----WlyeilsnEKRVRKGFWKQPPRIWDANPKQ-IRILNPYYTYVAATKLLQVPGQRKKKQKPTTGLLAITLAL 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958664623 330 TLCDQVDIYEF---LPSKRKTDVCYYHQKFFDSacTMGAYHPLLFEKNMVKHL 379
Cdd:cd23982   154 HLCDEVHIAGFgypDNGNSNQPIHYYNQITLKS--MANSGHNLNAEAQAIQRL 204
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 180-358 1.83e-18

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 85.00  E-value: 1.83e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 180 RCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKTT--IRLMNSQLVTTEKRFL--KDSLYTEGILIVWD 255
Cdd:cd23964    84 RCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSfyTFFPESLHNSLLKHVPqdKDTKYLFIPFKIRD 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 256 pSVYHADIPKWyqKPDYNFFETYKSYRRLNPSQP----FYILKPqmpwelwDIIQEI------SADLiqpNPPSSGMLGI 325
Cdd:cd23964   164 -YDYLDAVLSG--KPVPDGCDKGKRPPPLFGPKLnatnVRLLHP-------DFIRYLfnrwlnSSTS---YRPTTGALML 230

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1958664623 326 IIMMTLCDQVDIYEFLPSKRKTDVcYYHQKFFD 358
Cdd:cd23964   231 LTALHTCDQVSVYGFGYDPRFSLH-YYDKTFVK 262
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 167-229 3.08e-17

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 81.17  E-value: 3.08e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958664623 167 PKENFRTK-VGPWQRCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKTTIRLM 229
Cdd:cd23966    65 GENPYRTRdPNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFM 128
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 179-373 3.80e-16

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 77.20  E-value: 3.80e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 179 QRCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKTTIRLMN----SQLVTTEKRFLkdSLYTEGILIVW 254
Cdd:cd23978     2 HQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAhssvYRVLRRPQEFL--NRTPETTLIFW 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 255 DPsvyhadiPKWYQKPDY-NFFETYKSYRRLNPSQPFYILKPQMPWELWDIIQ-EISADLIQPNP-PSSGMLGIIIMMTL 331
Cdd:cd23978    80 GP-------PNKMQKDGKsNLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRgETGRDRKKSHSwLSTGWFTMVIAVEL 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958664623 332 CDQVDIYEFLP----SKR----KTDVCYYHQKFFDSACT--------MGAYHPLLFEK 373
Cdd:cd23978   153 CDNVHVYGMVPpnycSKRptpkKMPYHYYEPKGPDECVTyiqnehgrRGNHHRFITEK 210
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 179-340 1.29e-15

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 75.16  E-value: 1.29e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 179 QRCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKTTIRLMnsqlvttekrflkdslYTEGILIVW---D 255
Cdd:cd23983     3 RRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMT----------------YPEGAPKSEqeyD 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 256 P-SVYHADIpkwYQKPDYNFF------ETYKSYRRL------------NPSQpFYILKPQmpwelwdIIQEISADLIQ-P 315
Cdd:cd23983    67 PtSLFVAVL---FKSVDFAWLkamvkkEPLSFWSRLffwkevadsiplKPSQ-FRILNPL-------IIKETALDILQyP 135

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1958664623 316 NP-----------PSSGMLGIIIMMTLCDQVDIYEF 340
Cdd:cd23983   136 EPqsrlwgwdknvPTLGVTAVVLATHLCDEVSLAGF 171
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 179-367 1.64e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 75.28  E-value: 1.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 179 QRCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKTTIRLMNSQ----LVTTEKRFLKDSLYTegILIVW 254
Cdd:cd23977     2 RRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTsvplLLRNQGYFFQQSRDT--KYVIW 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 255 DPSVYHADIPKwyqKPDYNFFETYKsyrRLNPSQPFYILKPQMPWELWDIIQ-EISADLIQPNP-PSSGMLGIIIMMTLC 332
Cdd:cd23977    80 GPERNMDRDGG---GKTYRALLTLA---KMYPHLQVYTLTEEKMAYCDGVFQnETGKNRMKSGSfLSTGWFTMILALELC 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1958664623 333 DQVDIY-----EFLPSKRKTDVCY-YHQKFFDSACTMGAYH 367
Cdd:cd23977   154 EEILVYgmvsdSYCRNKNHSSVPYhYYEKGRLDECRMYLVH 194
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 181-379 1.69e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 73.20  E-value: 1.69e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 181 CAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKTTIRLMNS----------QLVTTEKRFLKDsLYTEGI 250
Cdd:cd23970    71 CAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPsilekyynnlLTIQDRNNFFLS-LKKLDG 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 251 LIVWDPSV-YHADIPKWYQKPDynFFETYKSYRRLNPSQPFYIlkpqMPW--ELWDIIQeisadlIQPNPPSSGMLGIII 327
Cdd:cd23970   150 AILWIPAFfFHTSATVTRTLVD--FFVEHRGQLKVQLAWPGNI----MQHvnRYWKTKH------LSPKRLSTGILMYTL 217

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958664623 328 MMTLCDQVDIYEFLP---SKRKTDVCYYHQKFFDSACTMG--AYHPLLFEKNMVKHL 379
Cdd:cd23970   218 ASAICEEIHLYGFWPfgfDPTGTPLPYHYYDKKGTKFTTKwqESHQLPAEFVLLYKM 274
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 177-379 6.36e-14

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 70.16  E-value: 6.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 177 PWQRCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKTTIRLMnsqlvttekrflkdslYTEGILIvwDP 256
Cdd:cd23984     1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLC----------------YPESIFS--DP 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 257 SVYHAD-----IP------KW---------------YQKPDYNFFetYKSY--RRLNPSqpfyILKpQMPWELWDIIQEI 308
Cdd:cd23984    63 SHYDPNttvvlIPfkphdlRWlldllmgkkvsakgfWKKPALNLI--YKPNqiRILNPF----ILR-IAAYELLHFPKRF 135

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958664623 309 SADLIqPNPPSSGMLGIIIMMTLCDQVDI----YEFlpSKRKTDVCYYHQKFFdSACTMGAYHPLLFEKNMVKHL 379
Cdd:cd23984   136 PKEKK-PKHPTTGIIAITLALHICNEVHIagfkYDF--SNLNSTLHYYGNETM-SVMTKNEYHNISAEQKFLKDL 206
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 166-342 9.52e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 70.91  E-value: 9.52e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 166 LPKEN------FRTkvgpwqrCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKTTIRLMNSQLVTTEKR 239
Cdd:cd23969    53 LPEVSplkgkhFRT-------CAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSVIPHAYG 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 240 FLKDSLYTEGIL---------IVWDPSVYHADIPKWYQ-------KPDYNFFETYKSyRRLNpsqpfyilkpQMPWELWd 303
Cdd:cd23969   126 DLVNATDKEKFVerlrqlgdsILWIPAFVSKGGEEHVQwtneiilKHKLNVKTAYPP-LRLN----------HAIRGYW- 193

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1958664623 304 iiqeiSADLIQPNPPSSGMLGIIIMMTLCDQVDIYEFLP 342
Cdd:cd23969   194 -----LTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYP 227
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 181-373 1.19e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 70.28  E-value: 1.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 181 CAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKTTIRLMNSqlvTTEKRFLKD-----SLYTEGILIVWD 255
Cdd:cd23976    18 CALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAH---SSIQRILRNrnellNVSQGTVFIFWG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 256 PSVYHADIPKWYqkpdynffeTYKSYRRLNPSQP----FYILKPQMPW--ELWDiiQEISADLIQPNP-PSSGMLGIIIM 328
Cdd:cd23976    95 PSNYMRRDGKGL---------VYNNLQLMNQILPklkvYTITRHKMLQfdELFK--RETGKDRKISNTwLSTGWFTMIIA 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 329 MTLCDQVDIY-----EFLPSKRKTDVCY-YHQKFFDSACTM---------GAYHPLLFEK 373
Cdd:cd23976   164 LELCDRINVYgmvppDFCRDPNHPSVPYhYYEPSGPDECTMyishergrkGSHHRFITEK 223
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 179-340 1.20e-13

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 70.68  E-value: 1.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 179 QRCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKTTIRLMNSQLV---------------TTEKRFLKD 243
Cdd:cd23980    82 RRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFrelaqnvsmilvpfkTLDLEWVIS 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 244 SLYTEGILIVWDPsvyhadIPkwyqkpdynffetyksyRRLNPSQP-FYILKPQMpwelwdiIQEISADLIQPNP--PSS 320
Cdd:cd23980   162 ATTTGTISHTYVP------VP-----------------RKIKVKKEkILIYHPAF-------IKYVFDRWLQGHGryPST 211

                         170       180
                  ....*....|....*....|
gi 1958664623 321 GMLGIIIMMTLCDQVDIYEF 340
Cdd:cd23980   212 GILSVIFSLHVCDEVDLYGF 231
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 172-374 1.61e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 70.55  E-value: 1.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 172 RTKVGPWQRCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKT------TIRLMNS-------------Q 232
Cdd:cd23974    78 PNGRSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTsfytfsTNTLMNSlrayagvgfngppQ 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 233 LVTTEKRFLKD--------------SLYTEGILIVWDPSVY-----HADIPKWYQkPDynfFETYKSYRRLNPSqpfyIL 293
Cdd:cd23974   158 SKETRYIFLPDhdrdyllvkaalthTPIDRGRDKSKRPSKYfgkdvTAEKFKIYH-PD---FIRYLRNRFLWSP----IL 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 294 KPQMpwelWDIIQeisadliqpnpPSSGMLGIIIMMTLCDQVDIYEFLpskrKTDVCYYHQKFFDSactmgAYHPLLFEK 373
Cdd:cd23974   230 NTKQ----RDIYR-----------PSTGAVMLLAALHTCDQVSAYGFM----TPDYGKYSDHYYDK-----TYHKVVFYA 285


                  .
gi 1958664623 374 N 374
Cdd:cd23974   286 N 286
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 179-340 2.24e-13

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 68.80  E-value: 2.24e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 179 QRCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKTTIRLMNSQ-LVTTEKRFLKDSLYtegILIVWDPS 257
Cdd:cd23981     3 RRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEgAIQKPEQYEKDSLF---VLAGFKWQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 258 VYhadipKWYQkpdynfFETYKsyRRLNPSQPFY-ILKPQMPWELWDI-------IQEISADLI----------QPNPPS 319
Cdd:cd23981    80 DF-----KWLK------YIVYK--EKVSASDGFWkSVATRVPREPHEIrilnpyfIQEAAFSFIglpfnnglmgRGNIPT 146

                         170       180
                  ....*....|....*....|.
gi 1958664623 320 SGMLGIIIMMTLCDQVDIYEF 340
Cdd:cd23981   147 LGSVAITMALHNCDEVAVAGF 167
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 158-355 2.51e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 70.24  E-value: 2.51e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 158 NTTEWEGYLPKENFRTKVgpwQRCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKT-----TIRLMNSQ 232
Cdd:cd23972    65 NDSANAKLFFPRDTPGKC---IRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTsfygfTVNTMKNS 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 233 LVTTEKRFLKDSLYTEGILIVWDPS-----------VYHADIPKWYQKPDynffeTYKSYRRLNPS-QPFYILKPQMPWE 300
Cdd:cd23972   142 LISYWNLGFTRTPQGQDLQYIFIPSdirdyvmlrsaILGVPVPEGLDKGD-----RPHKYFGPEASaKKFKLLHPDFISY 216

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958664623 301 LWD------IIQEISADLIQpnpPSSGMLGIIIMMTLCDQVDIYEFL-PSKRKTDVCYYHQK 355
Cdd:cd23972   217 LTDrflkskLLNTHYGHLYM---PSTGALMLLTALHTCDQVSAYGFItSNYWKFSDHYYERK 275
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 166-342 1.14e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 67.67  E-value: 1.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 166 LPKEnFRTKVGPWQRCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTdNFQQDVGSKTTIRLMNSQLVTTEKRFLKDS- 244
Cdd:cd23971    53 LPKE-SPFSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPL-NDSKDVGSKTNLVTANPSILREKFHNLKKRr 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 245 -LYTEGILIVWDPSVYhadIPKWYQKpdYNFFETYKSYRRL----NPSQPF-----YILKPQMPWELWDiiqeisadlIQ 314
Cdd:cd23971   131 rPFVERMKVYGNALLL---LPAFSYT--SNTEPSLRALYTLedfgSPQKVLffnpeYLRNLSRYWKSKG---------LK 196

                         170       180
                  ....*....|....*....|....*...
gi 1958664623 315 PNPPSSGMLGIIIMMTLCDQVDIYEFLP 342
Cdd:cd23971   197 ARRLSTGLMLVSAALELCENVHLYGFWP 224
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 180-341 3.42e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 66.70  E-value: 3.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 180 RCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKTTIRLMNSQLVTTEKRFLKDSLYTEgilIVWDPSVY 259
Cdd:cd23973    85 RCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSSLMILQKRGFKN---IPQDKDIK 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 260 HADIPKWYQkpDYNFFETY--------KSYRRLNPSQPF---------YILKP--------------QMPWELWDIIQei 308
Cdd:cd23973   162 YILFPEGPR--DYQWLEALlknktipsGAYYGRRPRSYFsgdftedkyLVLHPdflryvknrflrskTLKGKYWAIYR-- 237

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1958664623 309 sadliqpnpPSSGMLGIIIMMTLCDQVDIYEFL 341
Cdd:cd23973   238 ---------PTTGAFLLLTALHLCDTVSAYGFI 261
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 174-348 3.80e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 66.32  E-value: 3.80e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 174 KVGPWQRCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPT-DNFQQDVGSKTTIRLMNSQLVT------TEKR--FLKD- 243
Cdd:cd23991    60 RGYPYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTgGNISKDVGSKTNLVTANPSIISikyaklNERRkpFLETv 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 244 SLYTEGILIvwdpsvyhadIPKWYQKPDYNF-FETYKSYRRLNPSQPFYILKPQMpweLWDIIQEISADLIQPNPPSSGM 322
Cdd:cd23991   140 SVYGDAFLL----------LPAFSYRSNTALsFKVYYTLEDFKAKQKVIFFHPIY---LKHLAQFWRSKGVQVYRLSTGL 206

                         170       180
                  ....*....|....*....|....*.
gi 1958664623 323 LGIIIMMTLCDQVDIYEFLPSKRKTD 348
Cdd:cd23991   207 MITSAALELCEEVKLYGFWPFSKNTE 232
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 178-359 4.83e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 66.12  E-value: 4.83e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 178 WQRCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKTTIRLMNSQLVTTEKRFLKDSLYTEGIL------ 251
Cdd:cd23987    64 FKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVQRAFEDLVNETWKEKFLqrlqsl 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 252 ---IVWDPSVYH---ADIPKWYQ----KPDYNFFETYKSYRRLNPSQPFYIlkpqmpwelwdiiqeisADLIQPNPPSSG 321
Cdd:cd23987   144 ngsILWIPAFMAkggEERVEWVNdlilKHHINVRTAYPSLRLLHAVRGYWL-----------------TNKVHIKRPTTG 206

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1958664623 322 MLGIIIMMTLCDQVDIYEFLPSKRKTD--VCYYHqkFFDS 359
Cdd:cd23987   207 LLMYTLATRFCNRIHLYGFWPFPRDQNqnPVKYH--YYDS 244
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 179-229 5.29e-11

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 62.97  E-value: 5.29e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958664623 179 QRCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKTTIRLM 229
Cdd:cd23979    81 RRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFM 131
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 177-369 9.13e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 62.16  E-value: 9.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 177 PWQRCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAP-TDNFQQDVGSKTTIRLMNSQLVttEKRF----LKDSLYTEGIL 251
Cdd:cd23989    62 PLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKTQLVTANPSII--DKRFqnllWSRKSFVESMK 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 252 IVWDPSVYhadIPKWYQKPDYN-FFETYKSYRRLNPSQPFYILKPQMpweLWDIIQEISADLIQPNPPSSGMLGIIIMMT 330
Cdd:cd23989   140 VYGRSYIY---MPAFSMKTGTDpSLRVYYTLADVGANQTVLFANPNF---LRNVGKFWKSKGVHAKRLSTGLFLVSAALG 213

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1958664623 331 LCDQVDIYEFLPSKRKTDVCYYHQKFFDSACTMGAYHPL 369
Cdd:cd23989   214 LCEEVTIYGFWPFSVDLDERTISHHYYDNVLPDSGFHAM 252
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 167-342 2.73e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 60.74  E-value: 2.73e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 167 PKENFRTKVgpwqrCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKTTIRLMNSQLV----------TT 236
Cdd:cd23988    58 PMKNRRFKT-----CAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVqrafggfrneSD 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 237 EKRFLKD-SLYTEGILivWDPSVY------HAD-IPKWYQKPDYNFFETYKSYRRLNPSQPFYIlkpqmpwelwdiiqei 308
Cdd:cd23988   133 REKFVHRlSMLNDSVL--WIPAFMvkggekHVEwVNALILKNKLKVRTAYPSLRLIHAVRGYWL---------------- 194

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1958664623 309 sADLIQPNPPSSGMLGIIIMMTLCDQVDIYEFLP 342
Cdd:cd23988   195 -TNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWP 227
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 178-340 4.14e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 60.24  E-value: 4.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 178 WQRCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAP-TDNFQQDVGSKTTIRLMNSQLVTteKRFLKdslytegiLIVWDP 256
Cdd:cd23990    64 FKKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPiSEKYVRDVGVKTDVVTINPSIIT--ERFHK--------LEKWRR 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 257 SVYhaDIPKWYQKPD------YNFFETYKSYR------RLNPSQPFYILKPQMpweLWDIIQEISADLIQPNPPSSGMLG 324
Cdd:cd23990   134 PFY--EVLQVYENASvvlpafYNTRNTDVSIRvkyvldDFESQQAVYYFHPQY---LLNVSRFWLRQGVRAKRISSGLML 208

                         170
                  ....*....|....*.
gi 1958664623 325 IIIMMTLCDQVDIYEF 340
Cdd:cd23990   209 VTAALELCEEVHLYGF 224
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 181-256 5.65e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 59.18  E-value: 5.65e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958664623 181 CAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKTTIRLMNSQ----LVTTEKRFLKDSlyTEGILIVWDP 256
Cdd:cd23975     4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTsvplLLKNPDYFFKET--NETIYVIWGP 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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