NCBI Conserved Domain Search

first malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439110 Cd Length: 103 Bit Score: 241.68 E-value: 7.80e-77

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 196 WGDISENVRIEVPNTDCSLPTKVFWIAGIIKLAGYNALLRYEGFENDSSLDFWCNICGSDIHPVGWCAASGKPLVPPRTV 275
Cdd:cd20120     1 WGDIAEGVRVEVPNTDCNLPTKVFWIAGIVKLAGYKALLRYEGFENDSSLDFWCNICGSDIHPVGWCATSGKPLVPPKTI 80

                          90       100
                  ....*....|....*....|...
gi 1958663609 276 QHKYTNWKAFLVKRLTGAKTLPP 298
Cdd:cd20120    81 QHKYTNWKAFLVKRLTGAKTLPP 103

third malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439116 Cd Length: 90 Bit Score: 204.64 E-value: 4.88e-63

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 411 FKEGMKLEAIDPLNLSTICVATIRKVLADGFLMIGIDGSEAADGSDWFCYHATSPSIFPVGFCEINMIELTPPRGYTKlP 490
Cdd:cd20126     1 FKEGMKLEAIDPLNLSTICVATVRKVLANGYLMIGIDGSEAADGSDWFCYHATSPSIFPVGFCEINMIELTPPRGYKK-P 79

                          90
                  ....*....|.
gi 1958663609 491 FKWFDYLRETG 501
Cdd:cd20126    80 FKWFDYLRETG 90

second malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439113 Cd Length: 85 Bit Score: 199.80 E-value: 2.31e-61

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 299 DFPQKVSESMQYPFKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEESEDRTDDFWCHMHSPLIHHIGWSRSIGHRF 378
Cdd:cd20123     1 DFSQKVSESMQYPFKPCMRVEVVDKTHLCRTRVAVVESVIGGRLRLVYEESEDGTDDFWCHMYSPLIHHIGWSRSIGHRF 80


                  ....*
gi 1958663609 379 KRSDI 383
Cdd:cd20123    81 KRSDI 85

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439109 Cd Length: 104 Bit Score: 179.95 E-value: 1.15e-53

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 196 WGDISENVRIEVPNTDCSL--PTKVFWIAGIIKLAGYNALLRYEGFENDSSLDFWCNICGSDIHPVGWCAASGKPLVPPR 273
Cdd:cd20119     1 WDNITVGMKVEVENTDTDLieDPTSFWIATVLKIAGYKALMRYEGFGTDDSKDFWVNLCSEDVHPVGWCATRGKPLIPPR 80

                          90       100
                  ....*....|....*....|....
gi 1958663609 274 TVQHKYTNWKAFLVKRLTGAKTLP 297
Cdd:cd20119    81 TIEHKYSDWKEFLVKRLTGARTLP 104

third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439089 [Multi-domain] Cd Length: 91 Bit Score: 178.26 E-value: 3.33e-53

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 411 FKEGMKLEAIDPLNLSTICVATIRKVLADGFLMIGIDGSEAADGSDWFCYHATSPSIFPVGFCEINMIELTPPRGYTKLP 490
Cdd:cd20099     1 FKVGMKLEAVDPLNLSSICVATVRKVLRFGYLVIGIDGPSADDGSDWFCCHASSPFIFPVGFAEKNGIELTPPRGYESKP 80

                          90
                  ....*....|.
gi 1958663609 491 FKWFDYLRETG 501
Cdd:cd20099    81 FDWEEYLEETG 91

fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439119 Cd Length: 71 Bit Score: 169.39 E-value: 2.85e-50

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958663609 517 HGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20129     1 HGFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 71

fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439090 Cd Length: 71 Bit Score: 168.24 E-value: 7.40e-50

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958663609 517 HGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20100     1 HGFKVGMKLEAVDLMEPRLICVATVTRVVGRLLRVHFDGWDDEFDQWVDCDSPDIYPVGWCELVGYPLQPP 71

third malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439115 Cd Length: 107 Bit Score: 165.02 E-value: 3.96e-48

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 411 FKEGMKLEAIDPLNLSTICVATIRKVLADGFLMIGIDGSEA-ADGSDWFCYHATSPSIFPVGFCEINMIELTPPRGYTKL 489
Cdd:cd20125     1 FKEGMKLEAVDPLNLSAICVATVMKVLRFGYLMIRIDSYEPdASGSDWFCYHESSPCIFPAGFCEVNNITLTPPNGYDGR 80

                          90       100
                  ....*....|....*....|....*..
gi 1958663609 490 PFKWFDYLRETGSIAAPVKLFNKDVPN 516
Cdd:cd20125    81 TFTWEGYLRQTGATAAPQHLFHRIIPD 107

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439117 Cd Length: 91 Bit Score: 163.07 E-value: 1.15e-47

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 411 FKEGMKLEAIDPLNLSTICVATIRKVLADGFLMIGIDGSEAADGSDWFCYHATSPSIFPVGFCEINMIELTPPRGYTKLP 490
Cdd:cd20127     1 FEEGMKLEAIDPLNLGNICVATVCKVLLDGYLMIGIDGGPSTDGSDWFCYHASSHAIFPVGFCQKNDIELTPPKGYDAQT 80

                          90
                  ....*....|.
gi 1958663609 491 FKWFDYLRETG 501
Cdd:cd20127    81 FNWENYLEKTK 91

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) and similar proteins; L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439111 Cd Length: 102 Bit Score: 162.32 E-value: 3.14e-47

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 196 WGDISENVRIEVPNTDCSLPTKVFWIAGIIKLAGYNALLRYEGFENDSSLDFWCNICGSDIHPVGWCAASGKPLVPPRTV 275
Cdd:cd20121     1 WEDVMEGMKVEVLNTDAVLPSRVYWIASVIQLAGYKALLRYEGFENDSSHDFWCNLGTVDVHPIGWCAINSKILVPPQTI 80

                          90       100
                  ....*....|....*....|..
gi 1958663609 276 QHKYTNWKAFLVKRLTGAKTLP 297
Cdd:cd20121    81 HAKFTDWRGYLMKRLVGSRTIP 102

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.

Pssm-ID: 214723 Cd Length: 96 Bit Score: 158.18 E-value: 6.93e-46

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609  495 DYLRETGSIAAPVKLFNK--DVPNHGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLY 572
Cdd:smart00561   2 DYLEETGARAAPVELFKQpvDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGWDDKYDFWCHADSPDIF 81

                           90
                   ....*....|....*
gi 1958663609  573 PVGWCQLTGYQLQPP 587
Cdd:smart00561  82 PVGWCEKNGHPLQPP 96

first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439087 Cd Length: 105 Bit Score: 155.16 E-value: 1.43e-44

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 196 WGDISENVRIEVPNTDCSLPT---KVFWIAGIIKLAGYNALLRYEGFENDSSLDFWCNICGSDIHPVGWCAASGKPLVPP 272
Cdd:cd20097     1 WEKVKIGVKVEVANRDDDKPTdnvKVYWFARIIKVAGYRVLLRYEGYDEDSSHDFWINLCSNEIHPIGYAAENGKILVPP 80

                          90       100
                  ....*....|....*....|....*
gi 1958663609 273 RTVQHKYTNWKAFLVKRLTGAKTLP 297
Cdd:cd20097    81 KSIEDKENDWKEYIMKRLHGKRTIP 105

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439120 Cd Length: 75 Bit Score: 152.84 E-value: 3.88e-44

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958663609 515 PNHGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20130     2 PNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQWVDCESPDIYPVGWCELTGYQLQPP 74

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439088 Cd Length: 83 Bit Score: 143.54 E-value: 1.13e-40

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 299 DFPQKVSESMQY-PFKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEESEDRTDDFWCHMHSPLIHHIGWSRSIGHR 377
Cdd:cd20098     1 DFHEKVLESLKStPFKVGMRLEVVDKMCISRTRVAVVEEVVGGRLRLQYVDSEDDDDDFWCHMKSPLIHPVGWSQAVGHK 80


                  ..
gi 1958663609 378 FK 379
Cdd:cd20098    81 IR 82

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439114 Cd Length: 84 Bit Score: 136.51 E-value: 3.52e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 299 DFPQKVSESMQYPFKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEESEDrTDDFWCHMHSPLIHHIGWSRSIGHRF 378
Cdd:cd20124     1 DFHIKMAESMKYPFRQGMRVEVVDKSQVSRTRMAVVDTVIGGRLRLLYEDGDS-DDDFWCHMWSPLIHPVGWSRRVGHSI 79


                  ....
gi 1958663609 379 KRSD 382
Cdd:cd20124    80 KMSD 83

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439092 Cd Length: 90 Bit Score: 128.13 E-value: 3.14e-35

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958663609 516 NHGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20102     1 PHGFRVGMKLEAVDRKNPSLICVATVTDVIGNRFLVHFDGWDDSYDYWCDPDSPYIHPVGWCEENGKTLQPP 72

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.

Pssm-ID: 460712 Cd Length: 66 Bit Score: 125.70 E-value: 1.43e-34

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958663609 523 MKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVLGGRLRLRFDGWDDSYDFWCHADSPDIHPVGWCEKNGHPLQPP 65

fourth malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt); dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439118 Cd Length: 72 Bit Score: 121.30 E-value: 5.17e-33

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958663609 517 HGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20128     1 HGFEVGMSLECADLMDPRLVCVATVARVVGRLLKVHFDGWTDEYDQWLDCESADIYPVGWCVLVNHKLEGP 71

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.

Pssm-ID: 214723 Cd Length: 96 Bit Score: 121.20 E-value: 1.26e-32

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609  386 KQDGHFDTPPHLFAKVkeVDQSGEWFKEGMKLEAIDPLNLSTICVATIRKVLaDGFLMIGIDGSeaaDGSDWFCYHATSP 465
Cdd:smart00561   5 EETGARAAPVELFKQP--VDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVK-GYRLLLHFDGW---DDKYDFWCHADSP 78

                           90
                   ....*....|....*...
gi 1958663609  466 SIFPVGFCEINMIELTPP 483
Cdd:smart00561  79 DIFPVGWCEKNGHPLQPP 96

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.

Pssm-ID: 214723 Cd Length: 96 Bit Score: 119.28 E-value: 5.08e-32

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609  289 RLTGAKTLPPDFPQKVSESMQYPFKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEESEDRtDDFWCHMHSPLIHHI 368
Cdd:smart00561   5 EETGARAAPVELFKQPVDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGWDDK-YDFWCHADSPDIFPV 83

                           90
                   ....*....|.
gi 1958663609  369 GWSRSIGHRFK 379
Cdd:smart00561  84 GWCEKNGHPLQ 94

third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439093 Cd Length: 73 Bit Score: 113.53 E-value: 3.19e-30

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958663609 515 PNHGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20103     1 PPHGFEVGMKLEAVDKRNPRLIRVATVADVEDYRVKLHFDGWPDIYDFWVDDDSPDIHPPGWCSKTGHPLEPP 73

first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439083 Cd Length: 94 Bit Score: 110.44 E-value: 6.14e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 205 IEVPNTDcslPTKVFWIAGIIKLAGYNALLRYEGFENDSSLDFWCNICGSDIHPVGWCAASGKPLVPPRTVQHKYTNWKA 284
Cdd:cd20093    10 LEVPNKN---NPDTYWVATVVMTCGPLLRLRYVGYEDDRSADFWCDLSSGDVHPIGWCAQNGKPLQPPADIKEKELDWAE 86


                  ....*...
gi 1958663609 285 FLVKRLTG 292
Cdd:cd20093    87 FLIKELTG 94

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439127 Cd Length: 75 Bit Score: 108.76 E-value: 1.60e-28

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958663609 515 PNHGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20137     1 PPHGFQVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPDIHPAGWCSKTGHPLQPP 73

first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439091 Cd Length: 101 Bit Score: 107.36 E-value: 1.16e-27

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958663609 517 HGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20101     4 NGFKVGMKLEGIDPKHPSLFCVLSVAEVRGYRLRLHFDGYSECYDFWVNADSPDIFPVGWCEKTGHKLQPP 74

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439092 Cd Length: 90 Bit Score: 105.79 E-value: 3.05e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 411 FKEGMKLEAIDPLNLSTICVATIRKVLADGFLmIGIDGSEaaDGSDWFCyHATSPSIFPVGFCEINMIELTPPRGYTKLP 490
Cdd:cd20102     4 FRVGMKLEAVDRKNPSLICVATVTDVIGNRFL-VHFDGWD--DSYDYWC-DPDSPYIHPVGWCEENGKTLQPPKGYSPGN 79

                          90
                  ....*....|.
gi 1958663609 491 FKWFDYLRETG 501
Cdd:cd20102    80 FSWDKYLEETN 90

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).

Pssm-ID: 439080 Cd Length: 61 Bit Score: 103.49 E-value: 8.82e-27

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958663609 519 FRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEE-YDQWVDCESPDLYPVGWCQ 578
Cdd:cd20088     1 FKVGMKLEAVDPLNPSEICVATVVKVVGGRLLLHFDGWDPSrYDFWCDVDSPDIHPVGWCE 61

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439124 Cd Length: 93 Bit Score: 103.38 E-value: 1.97e-26

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958663609 514 VPNHGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20134     1 PPPLGFQVGMKLEAVDRMNPSLVCVASVTDVVDSRFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQKQGKPLTPP 74

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439128 Cd Length: 78 Bit Score: 103.08 E-value: 2.01e-26

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958663609 512 KDVPNHGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20138     2 KVKPPHGFQKNMKLEVVDKRNPMLIRVATVADTDDHRVKVHFDGWNNCYDYWIDADSPDIHPAGWCAKTGHPLQPP 77

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439112 Cd Length: 83 Bit Score: 103.00 E-value: 2.33e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 299 DFPQKVSESMQYPFKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEESEDRTDDFWCHMHSPLIHHIGWSRSIGHRF 378
Cdd:cd20122     1 NFHNKVNESLRSRFRLGLNLECVDKNRISQVRVATVTKIVGKRLHLRYEGSEPDDDGFWCHEDSPLIHPVGWAQTVGHNL 80


                  ...
gi 1958663609 379 KRS 381
Cdd:cd20122    81 AAS 83

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.

Pssm-ID: 460712 Cd Length: 66 Bit Score: 101.82 E-value: 3.38e-26

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 415 MKLEAIDPLNLSTICVATIRKVLaDGFLMIGIDGSeaaDGSDWFCYHATSPSIFPVGFCEINMIELTPPR 484
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVL-GGRLRLRFDGW---DDSYDFWCHADSPDIHPVGWCEKNGHPLQPPK 66

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439125 Cd Length: 93 Bit Score: 101.80 E-value: 6.66e-26

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 518 GFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20135     5 GFRVGMKLEAVDKKNPSFICVATITDMVDNRLLIHFDNWDESYDYWCDASSPYIHPVGYCQEHGRTLTTP 74

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439126 Cd Length: 92 Bit Score: 101.62 E-value: 8.64e-26

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958663609 519 FRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20136     5 FQVGMKLEAVDRKNPSLVCVATIADIVEDRLLVHFDNWDDSYDYWCDVNSPYIQPVGWCQENGRTLVAP 73

third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439085 Cd Length: 92 Bit Score: 101.18 E-value: 1.27e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 411 FKEGMKLEAIDPLNLSTICVATIRKVLADGFLMIGID-GSEAADGSDWFCYHATSPSIFPVGFCEINMIELTPPRGYTKL 489
Cdd:cd20095     1 FKVGMKLEALHPKNPSTICPATVTKVFNEYYFLVEIDdLRPEESEKITFVCHANSPGIFPVGWCAKNGLRLTPPPGYPKS 80

                          90
                  ....*....|..
gi 1958663609 490 PFKWFDYLRETG 501
Cdd:cd20095    81 EFDWDSYLKLCG 92

fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439086 Cd Length: 73 Bit Score: 100.39 E-value: 1.51e-25

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 519 FRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGW-EEEYDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20096     1 FERGMKLEAVNPENPNQICVATITKVVGPLLWLHLDSEkKLSPNIIVDVESTDIFPVGWCESNGYPLVTP 70

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439129 Cd Length: 82 Bit Score: 99.56 E-value: 3.12e-25

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958663609 515 PNHGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20139     5 PPHGFQVNMKLEAVDKRNPILIRVATIVDKDDHRIKLHFDGWDHNYDFWVDADSPDIHPVGWCDKTGHALQVP 77

first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439091 Cd Length: 101 Bit Score: 100.42 E-value: 3.32e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 411 FKEGMKLEAIDPLNLSTICVATIRKVlaDGF-LMIGIDG-SEAADgsdwFCYHATSPSIFPVGFCEINMIELTPPRGYTK 488
Cdd:cd20101     6 FKVGMKLEGIDPKHPSLFCVLSVAEV--RGYrLRLHFDGySECYD----FWVNADSPDIFPVGWCEKTGHKLQPPKGYTS 79

                          90       100
                  ....*....|....*....|..
gi 1958663609 489 LPFKWFDYLRETGSIAAPVKLF 510
Cdd:cd20101    80 ETFSWSAYLKLTKAQAAPKHLF 101

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439101 Cd Length: 94 Bit Score: 98.36 E-value: 1.13e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 199 ISENVRIEVPNTDCSlptKVFWIAGIIKLAGYNALLRYEGFENDSSLDFWCNICGSDIHPVGWCAASGKPLVPPRTVQHK 278
Cdd:cd20111     4 FSPGMKLEVAVRTDP---NTYWVATIITTCGQLLLLRYDGYGEDRRADFWCDIMTADLHPIGWCEQNGKTLRPPEGIRDK 80

                          90
                  ....*....|....
gi 1958663609 279 YTNWKAFLVKRLTG 292
Cdd:cd20111    81 LSDWEEFLAQTLTG 94

second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg family; The Sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, Polycomb protein sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439082 Cd Length: 75 Bit Score: 97.81 E-value: 1.19e-24

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958663609 519 FRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20092     6 FKVGMKLEAVDRKNPQLICPATVGDVDGDEIHISFDGWRGAFDYWCRYDSRDIFPVGWCKKTGHPLQPP 74

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439102 Cd Length: 94 Bit Score: 96.98 E-value: 4.20e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 203 VRIEVPNTDcslPTKVFWIAGIIKLAGYNALLRYEGFENDSSLDFWCNICGSDIHPVGWCAASGKPLVPPRTVQHKYTNW 282
Cdd:cd20112     8 MKLEVANKS---NPDTYWVATIITTCGQLLLLRYCGYGDDRRADFWCDVMTADLHPVGWCTQNNKVLMPPDAIKEKYTDW 84

                          90
                  ....*....|
gi 1958663609 283 KAFLVKRLTG 292
Cdd:cd20112    85 TEFLIHDLTG 94

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439123 Cd Length: 101 Bit Score: 94.86 E-value: 2.50e-23

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958663609 517 HGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20133     4 NGFKVGMRLEGIDPEHPSLFCVLSVAEVQGYRLRLHFDGYSECYDFWVNADSPDIHPVGWCEKTGHKLLPP 74

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439122 Cd Length: 101 Bit Score: 93.83 E-value: 5.53e-23

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958663609 517 HGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20132     4 NGFKVGMKLEGVDPEHQSMYCVLTVAEVCGYRIRLHFDGYSDCYDFWVNADSPDIHPVGWCEKTGHKLHPP 74

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).

Pssm-ID: 439080 Cd Length: 61 Bit Score: 91.55 E-value: 1.22e-22

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958663609 312 FKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEESEDRTDDFWCHMHSPLIHHIGWSR 372
Cdd:cd20088     1 FKVGMKLEAVDPLNPSEICVATVVKVVGGRLLLHFDGWDPSRYDFWCDVDSPDIHPVGWCE 61

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg (Scm) and similar proteins; Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439100 Cd Length: 75 Bit Score: 89.05 E-value: 1.33e-21

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 518 GFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20110     5 LFKVGMKLEAVDRKNPHLICPATVGAVKDDQIFVTFDGWRGAFDYWCRYDSRDIFPVGWCARSGHPLQPP 74

second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) and similar proteins; SCML2 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439099 Cd Length: 77 Bit Score: 88.02 E-value: 3.11e-21

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958663609 515 PNHGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20109     2 PLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVFITFDGWRGAFDYWCKYDSRDIFPVGWCRLTGDVLQPP 74

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439121 Cd Length: 109 Bit Score: 87.63 E-value: 1.06e-20

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958663609 517 HGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20131    12 NGFKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQPP 82

second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1 (SCMH1) and similar proteins; SCMH1 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439098 Cd Length: 75 Bit Score: 84.22 E-value: 7.58e-20

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958663609 516 NHgFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20108     4 NF-FKTGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGWRGAFDYWCRYDSRDIFPVGWCSLTGDNLQPP 74

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.

Pssm-ID: 214723 Cd Length: 96 Bit Score: 84.22 E-value: 1.36e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609  172 NYINSNSFIAAPVACFKHAPMGTcWGDISENVRIEVPNTDcsLPTKvFWIAGIIKLAGYNALLRYEGFenDSSLDFWCNI 251
Cdd:smart00561   2 DYLEETGARAAPVELFKQPVDSP-PNGFKVGMKLEAVDPR--NPSL-ICVATVVEVKGYRLLLHFDGW--DDKYDFWCHA 75

                           90       100
                   ....*....|....*....|.
gi 1958663609  252 CGSDIHPVGWCAASGKPLVPP 272
Cdd:smart00561  76 DSPDIFPVGWCEKNGHPLQPP 96

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.

Pssm-ID: 460712 Cd Length: 66 Bit Score: 82.56 E-value: 1.68e-19

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958663609 316 MRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEESEDRtDDFWCHMHSPLIHHIGWSRSIGHRFK 379
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVLGGRLRLRFDGWDDS-YDFWCHADSPDIHPVGWCEKNGHPLQ 63

three malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439106 Cd Length: 93 Bit Score: 82.93 E-value: 2.96e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 411 FKEGMKLEAIDPLNLSTICVATIRKVLADGFLMIGIDGSEA-ADGSDWFCyHATSPSIFPVGFCEINMIELTPPRGYTKL 489
Cdd:cd20116     3 FTVGMKLEVVDPREPFHICPASVTKVFNNHYFQVTVDDLRPeASENSMLC-HADSLGILPVQWCLKNGVNLTPPKGYSGQ 81

                          90
                  ....*....|..
gi 1958663609 490 PFKWFDYLRETG 501
Cdd:cd20116    82 DFDWADYQKQCG 93

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1; Sex comb on midleg homolog 1 (SCMH1) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439095 Cd Length: 131 Bit Score: 82.73 E-value: 1.08e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 491 FKWFDYLRETGSIAAPVKLFNKDV--PNHGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCES 568
Cdd:cd20105     2 FSWDKYLKETGAVPAPVHCFKQSYtpPVNEFKIGMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVDS 81

                          90
                  ....*....|....*....
gi 1958663609 569 PDLYPVGWCQLTGYQLQPP 587
Cdd:cd20105    82 SEIQPIGNCEKNGGMLQPP 100

first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439081 Cd Length: 97 Bit Score: 81.19 E-value: 1.50e-18

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958663609 515 PNHGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20091     6 PVNEFKVGMKLEAQDPRNLTSTCIATVVGIQGPRLRLRLDGSDNKNDFWRLVDSSDIHPVGWCEKNGGLLQPP 78

third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439105 Cd Length: 94 Bit Score: 79.14 E-value: 7.82e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 411 FKEGMKLEAIDPLNLSTICVATIRKVLADGFLMIGIDG---SEAADGSdwFCYHATSPSIFPVGFCEINMIELTPPRGYT 487
Cdd:cd20115     3 FSEGMKLEAVDPAAPFTISPATVAKVFNEKFFLVEMDDlrpEEAGAHS--FVCHRDSPGIFPVQWSLKNGLHLSPPPGYP 80

                          90
                  ....*....|....
gi 1958663609 488 KLPFKWFDYLRETG 501
Cdd:cd20115    81 GQDFDWADYLKQCG 94

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).

Pssm-ID: 439080 Cd Length: 61 Bit Score: 77.30 E-value: 1.30e-17

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958663609 411 FKEGMKLEAIDPLNLSTICVATIRKVLaDGFLMIGIDGSEaaDGSDWFCYHATSPSIFPVGFCE 474
Cdd:cd20088     1 FKVGMKLEAVDPLNPSEICVATVVKVV-GGRLLLHFDGWD--PSRYDFWCDVDSPDIHPVGWCE 61

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439123 Cd Length: 101 Bit Score: 77.91 E-value: 2.18e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 406 QSGEWFKEGMKLEAIDPLNLSTICVATIRKVLadGFLM-IGIDG-SEAADgsdwFCYHATSPSIFPVGFCEINMIELTPP 483
Cdd:cd20133     1 QSRNGFKVGMRLEGIDPEHPSLFCVLSVAEVQ--GYRLrLHFDGySECYD----FWVNADSPDIHPVGWCEKTGHKLLPP 74

                          90       100
                  ....*....|....*....|....*..
gi 1958663609 484 RGYTKLPFKWFDYLRETGSIAAPVKLF 510
Cdd:cd20133    75 KGYKDGEFNWSSYLKTCKAQAAPKNLF 101

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439124 Cd Length: 93 Bit Score: 77.57 E-value: 2.73e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 411 FKEGMKLEAIDPLNLSTICVATIRKVLADGFLmIGIDGSEaaDGSDWFCyHATSPSIFPVGFCEINMIELTPPRGYTKLP 490
Cdd:cd20134     6 FQVGMKLEAVDRMNPSLVCVASVTDVVDSRFL-VHFDNWD--DTYDYWC-DPSSPYIHPVGWCQKQGKPLTPPQDYPDPD 81

                          90
                  ....*....|..
gi 1958663609 491 -FKWFDYLRETG 501
Cdd:cd20134    82 nFSWEKYLEETG 93

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439125 Cd Length: 93 Bit Score: 77.15 E-value: 3.07e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 411 FKEGMKLEAIDPLNLSTICVATIRKVLaDGFLMIGIDGSEaaDGSDWFCyHATSPSIFPVGFCEINMIELTPPRGYTKLP 490
Cdd:cd20135     6 FRVGMKLEAVDKKNPSFICVATITDMV-DNRLLIHFDNWD--ESYDYWC-DASSPYIHPVGYCQEHGRTLTTPPGYKDPK 81

                          90
                  ....*....|..
gi 1958663609 491 -FKWFDYLRETG 501
Cdd:cd20135    82 hFSWEKYLEETN 93

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439108 Cd Length: 91 Bit Score: 75.63 E-value: 9.47e-17

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958663609 518 GFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEY-DQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20118     1 GFTKNMKLEAVNPRNPAEICVASITSVKGRLLWLHLEGLQNPVpEYIVDVESMDIFPVGWCEANGYPLTPP 71

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).

Pssm-ID: 439080 Cd Length: 61 Bit Score: 74.60 E-value: 1.12e-16

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958663609 199 ISENVRIEVPNTDCSlptKVFWIAGIIKLAGYNALLRYEGFEnDSSLDFWCNICGSDIHPVGWCA 263
Cdd:cd20088     1 FKVGMKLEAVDPLNP---SEICVATVVKVVGGRLLLHFDGWD-PSRYDFWCDVDSPDIHPVGWCE 61

first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439081 Cd Length: 97 Bit Score: 75.03 E-value: 2.36e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 411 FKEGMKLEAIDPLNLSTICVATIRKVLadGF-LMIGIDGSeaaDGSDWFCYHATSPSIFPVGFCEINMIELTPPRGYTKL 489
Cdd:cd20091    10 FKVGMKLEAQDPRNLTSTCIATVVGIQ--GPrLRLRLDGS---DNKNDFWRLVDSSDIHPVGWCEKNGGLLQPPLGFRMN 84

                          90
                  ....*....|.
gi 1958663609 490 PFKWFDYLRET 500
Cdd:cd20091    85 PSSWPMFLQKT 95

fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439086 Cd Length: 73 Bit Score: 73.43 E-value: 3.32e-16

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958663609 411 FKEGMKLEAIDPLNLSTICVATIRKVLaDGFLMIGIDGSeaADGSDWFCYHATSPSIFPVGFCEINMIELTPPRGY 486
Cdd:cd20096     1 FERGMKLEAVNPENPNQICVATITKVV-GPLLWLHLDSE--KKLSPNIIVDVESTDIFPVGWCESNGYPLVTPRKY 73

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439121 Cd Length: 109 Bit Score: 72.22 E-value: 2.65e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 398 FAKVKEVDQSGEWFKEGMKLEAIDPLNLSTICVATIRKVLadGF-LMIGIDG-SEAADgsdwFCYHATSPSIFPVGFCEI 475
Cdd:cd20131     1 FQDSQAVTHNKNGFKLGMKLEGIDPQHPSMYFILTVAEVC--GYrLRLHFDGySECHD----FWVNANSPDIHPAGWFEK 74

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1958663609 476 NMIELTPPRGYTKLPFKWFDYLRETGSIAAPVKLF 510
Cdd:cd20131    75 TGHKLQPPKGYKEEEFSWSQYLRSTRAQAAPKHLF 109

third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439085 Cd Length: 92 Bit Score: 70.36 E-value: 6.77e-15

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958663609 519 FRVGMKLEAVDLMEPRLICVATVTRIIH-RLLRIHFD---GWEEEYDQWV-DCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20095     1 FKVGMKLEALHPKNPSTICPATVTKVFNeYYFLVEIDdlrPEESEKITFVcHANSPGIFPVGWCAKNGLRLTPP 74

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439126 Cd Length: 92 Bit Score: 70.03 E-value: 1.19e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 411 FKEGMKLEAIDPLNLSTICVATIRKVLADGfLMIGIDGSEaaDGSDWFCyHATSPSIFPVGFCEINMIELTPPRGYTKlP 490
Cdd:cd20136     5 FQVGMKLEAVDRKNPSLVCVATIADIVEDR-LLVHFDNWD--DSYDYWC-DVNSPYIQPVGWCQENGRTLVAPQGYPN-P 79

                          90
                  ....*....|..
gi 1958663609 491 --FKWFDYLRET 500
Cdd:cd20136    80 ekFSWTEYLEAT 91

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439122 Cd Length: 101 Bit Score: 69.18 E-value: 2.91e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 406 QSGEWFKEGMKLEAIDPLNLSTICVATIRKVLadGFLM-IGIDGSeaADGSDwFCYHATSPSIFPVGFCEINMIELTPPR 484
Cdd:cd20132     1 YNKNGFKVGMKLEGVDPEHQSMYCVLTVAEVC--GYRIrLHFDGY--SDCYD-FWVNADSPDIHPVGWCEKTGHKLHPPK 75

                          90       100
                  ....*....|....*....|....*.
gi 1958663609 485 GYTKLPFKWFDYLRETGSIAAPVKLF 510
Cdd:cd20132    76 GYKEEEFNWQSYLKTCKAQAAPKSLF 101

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg and similar proteins; Sex comb on midleg (Scm) is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439097 Cd Length: 99 Bit Score: 68.80 E-value: 3.99e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 511 NKDVPNHGFRVGMKLEAVDlmePRLI---CVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20107     2 AQNPPKNEFKIGMKLEALD---PRNVtstCIATVVGVLGPRLRLRLDGSDNKNDFWRLVDSTEIHPIGHCEKNGGMLQPP 78

first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439083 Cd Length: 94 Bit Score: 68.07 E-value: 5.05e-14

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958663609 518 GFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEE--YDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20093     3 GFKPGMKLEVPNKNNPDTYWVATVVMTCGPLLRLRYVGYEDDrsADFWCDLSSGDVHPIGWCAQNGKPLQPP 74

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.

Pssm-ID: 460712 Cd Length: 66 Bit Score: 66.77 E-value: 5.97e-14

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958663609 219 FWIAGIIKLAGYNALLRYEGFenDSSLDFWCNICGSDIHPVGWCAASGKPLVPPR 273
Cdd:pfam02820  14 ICVATVVKVLGGRLRLRFDGW--DDSYDFWCHADSPDIHPVGWCEKNGHPLQPPK 66

first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb on midleg-like protein 2 (SCML2) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439096 Cd Length: 98 Bit Score: 68.03 E-value: 6.57e-14

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958663609 515 PNHGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20106     6 PVNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPIGTCEKEGDMLQPP 78

third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439089 [Multi-domain] Cd Length: 91 Bit Score: 66.94 E-value: 1.22e-13

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958663609 519 FRVGMKLEAVDLMEPRLICVATVTRIIH-RLLRIHFDGWEEEYDQ-W--VDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20099     1 FKVGMKLEAVDPLNLSSICVATVRKVLRfGYLVIGIDGPSADDGSdWfcCHASSPFIFPVGFAEKNGIELTPP 73

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1; Sex comb on midleg homolog 1 (SCMH1) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439095 Cd Length: 131 Bit Score: 68.10 E-value: 1.50e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 168 FSWGNYINSNSFIAAPVACFKHAPMGTCwGDISENVRIEVPNTDCSLPTkvfWIAGIIKLAGYNALLRYEGFENDSslDF 247
Cdd:cd20105     2 FSWDKYLKETGAVPAPVHCFKQSYTPPV-NEFKIGMKLEAQDPRNTTST---CIATVVGLTGARLRLRLDGSDNKN--DF 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958663609 248 WCNICGSDIHPVGWCAASGKPLVPPRTVQHKYTNWKAFLVKRLTGAKTLP 297
Cdd:cd20105    76 WRLVDSSEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAP 125

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1; Sex comb on midleg homolog 1 (SCMH1) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439095 Cd Length: 131 Bit Score: 68.10 E-value: 1.61e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 367 HIGWSRSIghrfkrsditkKQDGHFDTPPHLFaKVKEVDQSGEwFKEGMKLEAIDPLNLSTICVATIRKvLADGFLMIGI 446
Cdd:cd20105     1 HFSWDKYL-----------KETGAVPAPVHCF-KQSYTPPVNE-FKIGMKLEAQDPRNTTSTCIATVVG-LTGARLRLRL 66

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958663609 447 DGSeaaDGSDWFCYHATSPSIFPVGFCEINMIELTPPRGYTKLPFKWFDYLRET--GSIAAPVKLFNK 512
Cdd:cd20105    67 DGS---DNKNDFWRLVDSSEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTlnGAEMAPVRIFHK 131

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439107 Cd Length: 90 Bit Score: 65.29 E-value: 4.16e-13

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958663609 517 HGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEY-DQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20117     1 HCFKENMKLEAVNPICPEEICVATVTKVKGSYLWLQLEGSKKPIpECIVHVESMDIFPVGWCETNGYPLLHP 72

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439088 Cd Length: 83 Bit Score: 63.04 E-value: 2.65e-12

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958663609 517 HGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIH-FDGWEEEYDQWVDCESPDLYPVGWCQLTGYQL 584
Cdd:cd20098    13 TPFKVGMRLEVVDKMCISRTRVAVVEEVVGGRLRLQyVDSEDDDDDFWCHMKSPLIHPVGWSQAVGHKI 81

second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg family; The Sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, Polycomb protein sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439082 Cd Length: 75 Bit Score: 60.83 E-value: 1.02e-11

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958663609 411 FKEGMKLEAIDPLNLSTICVATIRKVLADgFLMIGIDGSEAAdgSDWFCYHaTSPSIFPVGFCEINMIELTPP 483
Cdd:cd20092     6 FKVGMKLEAVDRKNPQLICPATVGDVDGD-EIHISFDGWRGA--FDYWCRY-DSRDIFPVGWCKKTGHPLQPP 74

first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb on midleg-like protein 2 (SCML2) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439096 Cd Length: 98 Bit Score: 61.09 E-value: 1.90e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 411 FKEGMKLEAIDPLNLSTICVATIrkvladgflmIGIDGSE---AADGSDW---FCYHATSPSIFPVGFCEINMIELTPPR 484
Cdd:cd20106    10 FKVGMKLEARDPRNATSVCIATV----------IGITGARlrlRLDGSDNkndFWRLVDSSDIQPIGTCEKEGDMLQPPL 79

                          90
                  ....*....|....*.
gi 1958663609 485 GYTKLPFKWFDYLRET 500
Cdd:cd20106    80 GFQMNASSWPMFLLRT 95

first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439091 Cd Length: 101 Bit Score: 59.98 E-value: 3.82e-11

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 229 GYNALLRYEGFEndSSLDFWCNICGSDIHPVGWCAASGKPLVPPRTVQHKYTNWKAFLvkRLTGAKTLPP 298
Cdd:cd20101    33 GYRLRLHFDGYS--ECYDFWVNADSPDIFPVGWCEKTGHKLQPPKGYTSETFSWSAYL--KLTKAQAAPK 98

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439101 Cd Length: 94 Bit Score: 59.84 E-value: 4.88e-11

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958663609 518 GFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEY--DQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20111     3 GFSPGMKLEVAVRTDPNTYWVATIITTCGQLLLLRYDGYGEDRraDFWCDIMTADLHPIGWCEQNGKTLRPP 74

third malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439116 Cd Length: 90 Bit Score: 59.03 E-value: 6.41e-11

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958663609 519 FRVGMKLEAVDLMEPRLICVATVTRII-HRLLRIHFDGWE-EEYDQWV--DCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20126     1 FKEGMKLEAIDPLNLSTICVATVRKVLaNGYLMIGIDGSEaADGSDWFcyHATSPSIFPVGFCEINMIELTPP 73

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439122 Cd Length: 101 Bit Score: 59.17 E-value: 9.12e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 201 ENVRIEVPNTDCSLPtkvfwiagIIKLAGYNALLRYEGFENdsSLDFWCNICGSDIHPVGWCAASGKPLVPPRTVQHKYT 280
Cdd:cd20132    13 EGVDPEHQSMYCVLT--------VAEVCGYRIRLHFDGYSD--CYDFWVNADSPDIHPVGWCEKTGHKLHPPKGYKEEEF 82

                          90
                  ....*....|....*..
gi 1958663609 281 NWKAFLvkRLTGAKTLP 297
Cdd:cd20132    83 NWQSYL--KTCKAQAAP 97

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg and similar proteins; Sex comb on midleg (Scm) is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439097 Cd Length: 99 Bit Score: 58.78 E-value: 1.01e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 411 FKEGMKLEAIDPLNLSTICVATIRKVLADGfLMIGIDGSeaaDGSDWFCYHATSPSIFPVGFCEINMIELTPPRGYTKLP 490
Cdd:cd20107    10 FKIGMKLEALDPRNVTSTCIATVVGVLGPR-LRLRLDGS---DNKNDFWRLVDSTEIHPIGHCEKNGGMLQPPLGFRMNA 85

                          90
                  ....*....|
gi 1958663609 491 FKWFDYLRET 500
Cdd:cd20107    86 SSWPMFLLKT 95

second malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439084 Cd Length: 91 Bit Score: 58.40 E-value: 1.10e-10

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958663609 312 FKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEESEDR-TDDFWCHMHSPLIHHIGWSRSIGHRFK 379
Cdd:cd20094     4 IKVGMYLEVQDELNPYSVWIAKVLENVGGRLLLRYDGPEDSdSPDFWLFYLSPRLHPLGWAKSNGYTYR 72

first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439083 Cd Length: 94 Bit Score: 56.90 E-value: 4.31e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 406 QSGewFKEGMKLEAIDPLNLSTICVATIrkVLADG-FLMIGIDGSEAADGSDWFCyHATSPSIFPVGFCEINMIELTPPR 484
Cdd:cd20093     1 QSG--FKPGMKLEVPNKNNPDTYWVATV--VMTCGpLLRLRYVGYEDDRSADFWC-DLSSGDVHPIGWCAQNGKPLQPPA 75

                          90
                  ....*....|....*.
gi 1958663609 485 GYTKLPFKWFDYLRET 500
Cdd:cd20093    76 DIKEKELDWAEFLIKE 91

three malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439106 Cd Length: 93 Bit Score: 56.73 E-value: 5.48e-10

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958663609 517 HGFRVGMKLEAVDLMEPRLICVATVTRIIHRL-LRIHFDGWEEEYDQ---WVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20116     1 HSFTVGMKLEVVDPREPFHICPASVTKVFNNHyFQVTVDDLRPEASEnsmLCHADSLGILPVQWCLKNGVNLTPP 75

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439112 Cd Length: 83 Bit Score: 56.01 E-value: 7.07e-10

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 519 FRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQ-WVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20122    14 FRLGLNLECVDKNRISQVRVATVTKIVGKRLHLRYEGSEPDDDGfWCHEDSPLIHPVGWAQTVGHNLAAS 83

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439092 Cd Length: 90 Bit Score: 56.10 E-value: 8.09e-10

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958663609 242 DSSLDFWCNICGSDIHPVGWCAASGKPLVPPRTVQHKYTNWKAFL 286
Cdd:cd20102    42 DDSYDYWCDPDSPYIHPVGWCEENGKTLQPPKGYSPGNFSWDKYL 86

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439107 Cd Length: 90 Bit Score: 55.66 E-value: 1.10e-09

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958663609 411 FKEGMKLEAIDPLNLSTICVATIRKVLADgFLMIGIDGSEAADGSdwFCYHATSPSIFPVGFCEINMIELTPPR 484
Cdd:cd20117     3 FKENMKLEAVNPICPEEICVATVTKVKGS-YLWLQLEGSKKPIPE--CIVHVESMDIFPVGWCETNGYPLLHPR 73

first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439081 Cd Length: 97 Bit Score: 55.39 E-value: 1.56e-09

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958663609 221 IAGIIKLAGYNALLRYEGfeNDSSLDFWCNICGSDIHPVGWCAASGKPLVPPRTVQHKYTNWKAFLVKRLT 291
Cdd:cd20091    29 IATVVGIQGPRLRLRLDG--SDNKNDFWRLVDSSDIHPVGWCEKNGGLLQPPLGFRMNPSSWPMFLQKTLN 97

second malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439084 Cd Length: 91 Bit Score: 55.32 E-value: 1.62e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 199 ISENVRIEVpnTDCSLPTKVfWIAGIIKLAGYNALLRYEGFENDSSLDFWCnICGSD-IHPVGWCAASGKPLVPPRTVQH 277
Cdd:cd20094     4 IKVGMYLEV--QDELNPYSV-WIAKVLENVGGRLLLRYDGPEDSDSPDFWL-FYLSPrLHPLGWAKSNGYTYRPPKSLEK 79

                          90
                  ....*....|.
gi 1958663609 278 KYT--NWKAFL 286
Cdd:cd20094    80 LHAteEWKAIL 90

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439102 Cd Length: 94 Bit Score: 55.38 E-value: 1.75e-09

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958663609 519 FRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEY--DQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20112     4 FQPGMKLEVANKSNPDTYWVATIITTCGQLLLLRYCGYGDDRraDFWCDVMTADLHPVGWCTQNNKVLMPP 74

third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439093 Cd Length: 73 Bit Score: 54.21 E-value: 2.60e-09

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958663609 221 IAGIIKLAGYNALLRYEGFenDSSLDFWCNICGSDIHPVGWCAASGKPLVPP 272
Cdd:cd20103    24 VATVADVEDYRVKLHFDGW--PDIYDFWVDDDSPDIHPPGWCSKTGHPLEPP 73

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439108 Cd Length: 91 Bit Score: 54.45 E-value: 3.14e-09

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958663609 411 FKEGMKLEAIDPLNLSTICVATIRKVlaDGFLM-IGIDGSEAAdgSDWFCYHATSPSIFPVGFCEINMIELTPP 483
Cdd:cd20118     2 FTKNMKLEAVNPRNPAEICVASITSV--KGRLLwLHLEGLQNP--VPEYIVDVESMDIFPVGWCEANGYPLTPP 71

third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439093 Cd Length: 73 Bit Score: 53.82 E-value: 3.16e-09

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958663609 312 FKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEESEDrTDDFWCHMHSPLIHHIGWSRSIGH 376
Cdd:cd20103     5 FEVGMKLEAVDKRNPRLIRVATVADVEDYRVKLHFDGWPD-IYDFWVDDDSPDIHPPGWCSKTGH 68

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439126 Cd Length: 92 Bit Score: 54.24 E-value: 3.50e-09

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958663609 308 MQYPFKPCMRVEVVDKRHLCRTRVAVVESVIGGRLrLVYEESEDRTDDFWCHMHSPLIHHIGWSRSIGHRF 378
Cdd:cd20136     1 MPKEFQVGMKLEAVDRKNPSLVCVATIADIVEDRL-LVHFDNWDDSYDYWCDVNSPYIQPVGWCQENGRTL 70

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439123 Cd Length: 101 Bit Score: 54.41 E-value: 3.81e-09

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958663609 218 VFWIAGIIKLAGYNALLRYEGFEndSSLDFWCNICGSDIHPVGWCAASGKPLVPPRTVQHKYTNWKAFL 286
Cdd:cd20133    22 LFCVLSVAEVQGYRLRLHFDGYS--ECYDFWVNADSPDIHPVGWCEKTGHKLLPPKGYKDGEFNWSSYL 88

malignant brain tumor (MBT) repeat found in PHD finger protein 20-like protein 1 (PHF20L1) and similar domains; PHF20L1 associates with SOX2, antagonizes SOX2 ubiquitination and the sequential degradation induced by MLL1/WDR5 complexes. It binds both monomethylated Lys-42 and Lys-117 in SOX2 and thereby prevents SOX2 proteolysis. PHF20L1 also reads and controls enzyme levels of methylated DNMT1 in cells, thus representing a novel antagonist of DNMT1 degradation. PHF20L1 contains one MBT (malignant brain tumor) repeat. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the MBT repeat of PHF20L1 and similar domains that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439094 [Multi-domain] Cd Length: 60 Bit Score: 53.01 E-value: 3.84e-09

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958663609 519 FRVGMKLEAVDLMepRLICVATVTRI--IHRLLRIHFDGWEEEYDQWVDCESPDLYPVG 575
Cdd:cd20104     1 FKVGDRVDALDGE--GKWYEAKIVEVdeEENKVLVHYDGWSSRYDEWIDRDSERLRPLH 57

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439092 Cd Length: 90 Bit Score: 54.17 E-value: 4.21e-09

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958663609 311 PFKPCMRVEVVDKRH---LCrtrVAVVESVIGGRLRLVYEESEDRTDdFWCHMHSPLIHHIGW 370
Cdd:cd20102     3 GFRVGMKLEAVDRKNpslIC---VATVTDVIGNRFLVHFDGWDDSYD-YWCDPDSPYIHPVGW 61

first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb on midleg-like protein 2 (SCML2) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439096 Cd Length: 98 Bit Score: 53.39 E-value: 7.74e-09

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958663609 221 IAGIIKLAGYNALLRYEGFENDSslDFWCNICGSDIHPVGWCAASGKPLVPPRTVQHKYTNWKAFLVKRLTG 292
Cdd:cd20106    29 IATVIGITGARLRLRLDGSDNKN--DFWRLVDSSDIQPIGTCEKEGDMLQPPLGFQMNASSWPMFLLRTLNG 98

second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) and similar proteins; SCML2 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439099 Cd Length: 77 Bit Score: 52.58 E-value: 9.98e-09

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958663609 411 FKEGMKLEAIDPLNLSTICVATIRKVLADGfLMIGIDGSEAAdgSDWFCYHaTSPSIFPVGFCEINMIELTPP 483
Cdd:cd20109     6 FKVGMKLEAIDKKNPYLICPATIGDVKGDE-VFITFDGWRGA--FDYWCKY-DSRDIFPVGWCRLTGDVLQPP 74

second malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439084 Cd Length: 91 Bit Score: 51.85 E-value: 2.52e-08

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958663609 519 FRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWE--EEYDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20094     4 IKVGMYLEVQDELNPYSVWIAKVLENVGGRLLLRYDGPEdsDSPDFWLFYLSPRLHPLGWAKSNGYTYRPP 74

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg (Scm) and similar proteins; Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439100 Cd Length: 75 Bit Score: 50.91 E-value: 3.37e-08

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958663609 411 FKEGMKLEAIDPLNLSTICVATIRKVlADGFLMIGIDGSEAAdgSDWFCYHaTSPSIFPVGFCEINMIELTPP 483
Cdd:cd20110     6 FKVGMKLEAVDRKNPHLICPATVGAV-KDDQIFVTFDGWRGA--FDYWCRY-DSRDIFPVGWCARSGHPLQPP 74

second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1 (SCMH1) and similar proteins; SCMH1 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439098 Cd Length: 75 Bit Score: 50.33 E-value: 5.34e-08

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958663609 407 SGEWFKEGMKLEAIDPLNLSTICVATIRKVLADGFLmIGIDGSEAAdgSDWFCYHaTSPSIFPVGFCEINMIELTPP 483
Cdd:cd20108     2 SQNFFKTGMKLEAVDRKNPHFICPATIGEVRGSEVL-VTFDGWRGA--FDYWCRY-DSRDIFPVGWCSLTGDNLQPP 74

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439121 Cd Length: 109 Bit Score: 51.42 E-value: 5.93e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 218 VFWIAGIIKLAGYNALLRYEGFENdsSLDFWCNICGSDIHPVGWCAASGKPLVPPRTVQHKYTNWKAFLvkRLTGAKTLP 297
Cdd:cd20131    30 MYFILTVAEVCGYRLRLHFDGYSE--CHDFWVNANSPDIHPAGWFEKTGHKLQPPKGYKEEEFSWSQYL--RSTRAQAAP 105

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg and similar proteins; Sex comb on midleg (Scm) is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439097 Cd Length: 99 Bit Score: 50.31 E-value: 1.08e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958663609 221 IAGIIKLAGYNALLRYEGfeNDSSLDFWCNICGSDIHPVGWCAASGKPLVPPRTVQHKYTNWKAFLVKRLTGA 293
Cdd:cd20107    29 IATVVGVLGPRLRLRLDG--SDNKNDFWRLVDSTEIHPIGHCEKNGGMLQPPLGFRMNASSWPMFLLKTLNNA 99

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439103 Cd Length: 99 Bit Score: 50.19 E-value: 1.08e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958663609 312 FKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYE--ESEDRtDDFWCHMHSPLIHHIGWSRSIGH 376
Cdd:cd20113     4 IGPGSRLELQDFQDSLVAWIVVVVENIGGRLKLRYEglEGSDK-SDTWLFYLDPFLHQVGWAAQHGY 69

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439124 Cd Length: 93 Bit Score: 49.83 E-value: 1.20e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958663609 312 FKPCMRVEVVDKRHLCRTRVAVVESVIGGRLrLVYEESEDRTDDFWCHMHSPLIHHIGWSRSIG 375
Cdd:cd20134     6 FQVGMKLEAVDRMNPSLVCVASVTDVVDSRF-LVHFDNWDDTYDYWCDPSSPYIHPVGWCQKQG 68

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439088 Cd Length: 83 Bit Score: 49.55 E-value: 1.44e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958663609 396 HLFAKVKEVDQSGEwFKEGMKLEAIDPLNLSTICVATIRKVLADGFLMIGIDGSEAADGsdwFCYHATSPSIFPVGFC 473
Cdd:cd20098     1 DFHEKVLESLKSTP-FKVGMRLEVVDKMCISRTRVAVVEEVVGGRLRLQYVDSEDDDDD---FWCHMKSPLIHPVGWS 74

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439125 Cd Length: 93 Bit Score: 49.80 E-value: 1.45e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958663609 239 FEN-DSSLDFWCNICGSDIHPVGWCAASGKPLVPPRTVQH-KYTNWKAFLVK 288
Cdd:cd20135    40 FDNwDESYDYWCDASSPYIHPVGYCQEHGRTLTTPPGYKDpKHFSWEKYLEE 91

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439124 Cd Length: 93 Bit Score: 49.83 E-value: 1.55e-07

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1958663609 239 FEN-DSSLDFWCNICGSDIHPVGWCAASGKPLVPPR 273
Cdd:cd20134    40 FDNwDDTYDYWCDPSSPYIHPVGWCQKQGKPLTPPQ 75

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439126 Cd Length: 92 Bit Score: 49.23 E-value: 2.09e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958663609 239 FEN-DSSLDFWCNICGSDIHPVGWCAASGKPLVPPRTVQHKYT-NWKAFL 286
Cdd:cd20136    39 FDNwDDSYDYWCDVNSPYIQPVGWCQENGRTLVAPQGYPNPEKfSWTEYL 88

first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439083 Cd Length: 94 Bit Score: 48.81 E-value: 2.88e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958663609 309 QYPFKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYE-ESEDRTDDFWCHMHSPLIHHIGWSRS 373
Cdd:cd20093     1 QSGFKPGMKLEVPNKNNPDTYWVATVVMTCGPLLRLRYVgYEDDRSADFWCDLSSGDVHPIGWCAQ 66

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439122 Cd Length: 101 Bit Score: 48.76 E-value: 3.92e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958663609 312 FKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEESEDrTDDFWCHMHSPLIHHIGWSRSIGHRF 378
Cdd:cd20132     6 FKVGMKLEGVDPEHQSMYCVLTVAEVCGYRIRLHFDGYSD-CYDFWVNADSPDIHPVGWCEKTGHKL 71

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439125 Cd Length: 93 Bit Score: 48.26 E-value: 4.50e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958663609 312 FKPCMRVEVVDKRHLCRTRVAVVESVIGGRLrLVYEESEDRTDDFWCHMHSPLIHHIGWSRSIG 375
Cdd:cd20135     6 FRVGMKLEAVDKKNPSFICVATITDMVDNRL-LIHFDNWDESYDYWCDASSPYIHPVGYCQEHG 68

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439104 Cd Length: 98 Bit Score: 48.57 E-value: 4.74e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958663609 521 VGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEE-YDQWV---DCEspdLYPVGWCQLTGYQLQPP 587
Cdd:cd20114     6 VGSLIELQDSQNPFQYWIVRVIENVGGRLRLRYVGLEDEsHDQWLfylDTR---LRPVGWCQENNLRMEPP 73

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439128 Cd Length: 78 Bit Score: 47.61 E-value: 5.28e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958663609 312 FKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRlVYEESEDRTDDFWCHMHSPLIHHIGWSRSIGH 376
Cdd:cd20138     9 FQKNMKLEVVDKRNPMLIRVATVADTDDHRVK-VHFDGWNNCYDYWIDADSPDIHPAGWCAKTGH 72

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439112 Cd Length: 83 Bit Score: 47.53 E-value: 6.23e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958663609 398 FAKVKEVDQSGewFKEGMKLEAIDPLNLSTICVATIRKVLAdGFLMIGIDGSEAADGSDWfCyHATSPSIFPVGF 472
Cdd:cd20122     3 HNKVNESLRSR--FRLGLNLECVDKNRISQVRVATVTKIVG-KRLHLRYEGSEPDDDGFW-C-HEDSPLIHPVGW 72

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439123 Cd Length: 101 Bit Score: 47.86 E-value: 7.92e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 312 FKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEESEDrTDDFWCHMHSPLIHHIGWSRSIGHRFKRSDITKkqDGHF 391
Cdd:cd20133     6 FKVGMRLEGIDPEHPSLFCVLSVAEVQGYRLRLHFDGYSE-CYDFWVNADSPDIHPVGWCEKTGHKLLPPKGYK--DGEF 82


                  ....*.
gi 1958663609 392 DTPPHL 397
Cdd:cd20133    83 NWSSYL 88

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439114 Cd Length: 84 Bit Score: 47.14 E-value: 9.21e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958663609 519 FRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20124    14 FRQGMRVEVVDKSQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHSIKMS 82

third malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439115 Cd Length: 107 Bit Score: 47.92 E-value: 9.39e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958663609 519 FRVGMKLEAVDLMEPRLICVATVTRIIHR-LLRIHFDGWEEEYD--QWVdC---ESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20125     1 FKEGMKLEAVDPLNLSAICVATVMKVLRFgYLMIRIDSYEPDASgsDWF-CyheSSPCIFPAGFCEVNNITLTPP 74

first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439081 Cd Length: 97 Bit Score: 47.68 E-value: 9.44e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958663609 312 FKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEESeDRTDDFWCHMHSPLIHHIGW 370
Cdd:cd20091    10 FKVGMKLEAQDPRNLTSTCIATVVGIQGPRLRLRLDGS-DNKNDFWRLVDSSDIHPVGW 67

third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439105 Cd Length: 94 Bit Score: 46.40 E-value: 1.96e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958663609 517 HGFRVGMKLEAVDLMEPRLICVATVTRIIH-RLLRIHFDGW--EEEYDQWVDC--ESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20115     1 HCFSEGMKLEAVDPAAPFTISPATVAKVFNeKFFLVEMDDLrpEEAGAHSFVChrDSPGIFPVQWSLKNGLHLSPP 76

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439129 Cd Length: 82 Bit Score: 46.01 E-value: 2.01e-06

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958663609 312 FKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEeSEDRTDDFWCHMHSPLIHHIGWSRSIGH 376
Cdd:cd20139     9 FQVNMKLEAVDKRNPILIRVATIVDKDDHRIKLHFD-GWDHNYDFWVDADSPDIHPVGWCDKTGH 72

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439128 Cd Length: 78 Bit Score: 46.07 E-value: 2.04e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958663609 221 IAGIIKLAGYNALLRYEGFENDssLDFWCNICGSDIHPVGWCAASGKPLVPP 272
Cdd:cd20138    28 VATVADTDDHRVKVHFDGWNNC--YDYWIDADSPDIHPAGWCAKTGHPLQPP 77

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439102 Cd Length: 94 Bit Score: 46.52 E-value: 2.33e-06

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958663609 309 QYPFKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYE-ESEDRTDDFWCHMHSPLIHHIGW 370
Cdd:cd20112     1 QSSFQPGMKLEVANKSNPDTYWVATIITTCGQLLLLRYCgYGDDRRADFWCDVMTADLHPVGW 63

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg (Scm) and similar proteins; Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439100 Cd Length: 75 Bit Score: 45.52 E-value: 2.50e-06

                          10        20
                  ....*....|....*....|....*....
gi 1958663609 244 SLDFWCNICGSDIHPVGWCAASGKPLVPP 272
Cdd:cd20110    46 AFDYWCRYDSRDIFPVGWCARSGHPLQPP 74

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439129 Cd Length: 82 Bit Score: 45.63 E-value: 3.31e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958663609 221 IAGIIKLAGYNALLRYEGFenDSSLDFWCNICGSDIHPVGWCAASGKPL-VPPRTV 275
Cdd:cd20139    28 VATIVDKDDHRIKLHFDGW--DHNYDFWVDADSPDIHPVGWCDKTGHALqVPLGAS 81

second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1 (SCMH1) and similar proteins; SCMH1 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439098 Cd Length: 75 Bit Score: 45.32 E-value: 4.01e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958663609 222 AGIIKLAGYNALLRYEGFEndSSLDFWCNICGSDIHPVGWCAASGKPLVPP 272
Cdd:cd20108    26 ATIGEVRGSEVLVTFDGWR--GAFDYWCRYDSRDIFPVGWCSLTGDNLQPP 74

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439121 Cd Length: 109 Bit Score: 46.03 E-value: 4.03e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 312 FKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEESEDrTDDFWCHMHSPLIHHIGWSRSIGHR------FKRSD--- 382
Cdd:cd20131    14 FKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSE-CHDFWVNANSPDIHPAGWFEKTGHKlqppkgYKEEEfsw 92

                          90       100
                  ....*....|....*....|.
gi 1958663609 383 -----ITKKQDGhfdtPPHLF 398
Cdd:cd20131    93 sqylrSTRAQAA----PKHLF 109

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg and similar proteins; Sex comb on midleg (Scm) is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439097 Cd Length: 99 Bit Score: 45.69 E-value: 4.38e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958663609 312 FKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEESeDRTDDFWCHMHSPLIHHIG 369
Cdd:cd20107    10 FKIGMKLEALDPRNVTSTCIATVVGVLGPRLRLRLDGS-DNKNDFWRLVDSTEIHPIG 66

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439103 Cd Length: 99 Bit Score: 45.57 E-value: 4.66e-06

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958663609 522 GMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEE--YDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20113     7 GSRLELQDFQDSLVAWIVVVVENIGGRLKLRYEGLEGSdkSDTWLFYLDPFLHQVGWAAQHGYTLQPP 74

second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg family; The Sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, Polycomb protein sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439082 Cd Length: 75 Bit Score: 44.65 E-value: 5.05e-06

                          10        20
                  ....*....|....*....|....*..
gi 1958663609 246 DFWCNICGSDIHPVGWCAASGKPLVPP 272
Cdd:cd20092    48 DYWCRYDSRDIFPVGWCKKTGHPLQPP 74

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439103 Cd Length: 99 Bit Score: 45.19 E-value: 7.51e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 199 ISENVRIEVPNTDCSLptkVFWIAGIIKLAGYNALLRYEGFENDSSLDFWCNICGSDIHPVGWCAASGKPLVPPRTVQHK 278
Cdd:cd20113     4 IGPGSRLELQDFQDSL---VAWIVVVVENIGGRLKLRYEGLEGSDKSDTWLFYLDPFLHQVGWAAQHGYTLQPPAAIRHL 80

                          90
                  ....*....|..
gi 1958663609 279 YT--NWKAFLVK 288
Cdd:cd20113    81 KSeaEWQEILKK 92

fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439090 Cd Length: 71 Bit Score: 44.20 E-value: 8.12e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958663609 222 AGIIKLAGYNALLRYEGFenDSSLDFWCNICGSDIHPVGWCAASGKPLVPP 272
Cdd:cd20100    23 ATVTRVVGRLLRVHFDGW--DDEFDQWVDCDSPDIYPVGWCELVGYPLQPP 71

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439127 Cd Length: 75 Bit Score: 44.05 E-value: 8.71e-06

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958663609 312 FKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRlVYEESEDRTDDFWCHMHSPLIHHIGWSRSIGH 376
Cdd:cd20137     5 FQVNMKLEAVDRRNPALIRVASVEDVEDHRIK-IHFDGWSHGYDFWIDADHPDIHPAGWCSKTGH 68

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439101 Cd Length: 94 Bit Score: 44.82 E-value: 9.15e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958663609 309 QYPFKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEE-SEDRTDDFWCHMHSPLIHHIGWSRSIGHRFK 379
Cdd:cd20111     1 QNGFSPGMKLEVAVRTDPNTYWVATIITTCGQLLLLRYDGyGEDRRADFWCDIMTADLHPIGWCEQNGKTLR 72

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439117 Cd Length: 91 Bit Score: 44.05 E-value: 1.44e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958663609 519 FRVGMKLEAVDLMEPRLICVATVTRI-IHRLLRIHFDGweEEYDQWVDC-----ESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20127     1 FEEGMKLEAIDPLNLGNICVATVCKVlLDGYLMIGIDG--GPSTDGSDWfcyhaSSHAIFPVGFCQKNDIELTPP 73

second malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439084 Cd Length: 91 Bit Score: 43.76 E-value: 1.85e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958663609 411 FKEGMKLEAIDPLNLSTICVATIRKVLAdGFLMIGIDGSEAADGSDWFCYHaTSPSIFPVGFCEINMIELTPPRGYTKL 489
Cdd:cd20094     4 IKVGMYLEVQDELNPYSVWIAKVLENVG-GRLLLRYDGPEDSDSPDFWLFY-LSPRLHPLGWAKSNGYTYRPPKSLEKL 80

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439127 Cd Length: 75 Bit Score: 42.89 E-value: 2.61e-05

                          10        20
                  ....*....|....*....|....*..
gi 1958663609 246 DFWCNICGSDIHPVGWCAASGKPLVPP 272
Cdd:cd20137    47 DFWIDADHPDIHPAGWCSKTGHPLQPP 73

fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439090 Cd Length: 71 Bit Score: 42.66 E-value: 2.85e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958663609 310 YPFKPCMRVEVVDkrhLCRTR---VAVVESVIGgRLRLVYEESEDRTDDFWCHMHSPLIHHIGWSRSIGHR 377
Cdd:cd20100     1 HGFKVGMKLEAVD---LMEPRlicVATVTRVVG-RLLRVHFDGWDDEFDQWVDCDSPDIYPVGWCELVGYP 67

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439109 Cd Length: 104 Bit Score: 43.20 E-value: 3.53e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958663609 521 VGMKLEA----VDLME-PRLICVATVTRIIHRLLRIHFDGW--EEEYDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20119     6 VGMKVEVentdTDLIEdPTSFWIATVLKIAGYKALMRYEGFgtDDSKDFWVNLCSEDVHPVGWCATRGKPLIPP 79

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439112 Cd Length: 83 Bit Score: 42.52 E-value: 3.58e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958663609 221 IAGIIKLAGYNALLRYEGFENDSSlDFWCNICGSDIHPVGWCAASGKPLVPP 272
Cdd:cd20122    33 VATVTKIVGKRLHLRYEGSEPDDD-GFWCHEDSPLIHPVGWAQTVGHNLAAS 83

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1; Sex comb on midleg homolog 1 (SCMH1) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439095 Cd Length: 131 Bit Score: 43.83 E-value: 4.55e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 281 NWKAFLvkRLTGAKTLPPD-FPQKVSESMQyPFKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEESeDRTDDFWCH 359
Cdd:cd20105     3 SWDKYL--KETGAVPAPVHcFKQSYTPPVN-EFKIGMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGS-DNKNDFWRL 78

                          90
                  ....*....|
gi 1958663609 360 MHSPLIHHIG 369
Cdd:cd20105    79 VDSSEIQPIG 88

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439108 Cd Length: 91 Bit Score: 42.51 E-value: 5.56e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958663609 221 IAGIIKLAGYNALLRYEGFENDSSlDFWCNICGSDIHPVGWCAASGKPLVPP-RTVQHK 278
Cdd:cd20118    21 VASITSVKGRLLWLHLEGLQNPVP-EYIVDVESMDIFPVGWCEANGYPLTPPhKAVCKK 78

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439088 Cd Length: 83 Bit Score: 41.85 E-value: 7.27e-05

                          10        20        30
                  ....*....|....*....|....*....|...
gi 1958663609 234 LRYEGFENDSSlDFWCNICGSDIHPVGWCAASG 266
Cdd:cd20098    47 LQYVDSEDDDD-DFWCHMKSPLIHPVGWSQAVG 78

first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439087 Cd Length: 105 Bit Score: 42.29 E-value: 7.84e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 516 NHGFRVGMKLEAV----DLMEPRLIC--VATVTRIIHRLLRIHFDGWEEE--YDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20097     1 WEKVKIGVKVEVAnrddDKPTDNVKVywFARIIKVAGYRVLLRYEGYDEDssHDFWINLCSNEIHPIGYAAENGKILVPP 80

second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) and similar proteins; SCML2 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439099 Cd Length: 77 Bit Score: 41.02 E-value: 1.10e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958663609 222 AGIIKLAGYNALLRYEGFEndSSLDFWCNICGSDIHPVGWCAASGKPLVPP 272
Cdd:cd20109    26 ATIGDVKGDEVFITFDGWR--GAFDYWCKYDSRDIFPVGWCRLTGDVLQPP 74

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439104 Cd Length: 98 Bit Score: 41.63 E-value: 1.21e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 211 DCSLPtKVFWIAGIIKLAGYNALLRYEGFeNDSSLDFWCNICGSDIHPVGWCAASGKPLVPPRTVQ--HKYTNWKAFLVK 288
Cdd:cd20114    14 DSQNP-FQYWIVRVIENVGGRLRLRYVGL-EDESHDQWLFYLDTRLRPVGWCQENNLRMEPPTEICdlKSASEWKEALEK 91


                  ....*
gi 1958663609 289 RLTGA 293
Cdd:cd20114    92 SLAEA 96

first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb on midleg-like protein 2 (SCML2) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439096 Cd Length: 98 Bit Score: 41.45 E-value: 1.27e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958663609 312 FKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEESEDRtDDFWCHMHSPLIHHIG 369
Cdd:cd20106    10 FKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNK-NDFWRLVDSSDIQPIG 66

fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439086 Cd Length: 73 Bit Score: 40.30 E-value: 1.80e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958663609 201 ENVRIEVPNTDCslptkvfwIAGIIKLAGYNALLRYEGfENDSSLDFWCNICGSDIHPVGWCAASGKPLVPPRT 274
Cdd:cd20096     8 EAVNPENPNQIC--------VATITKVVGPLLWLHLDS-EKKLSPNIIVDVESTDIFPVGWCESNGYPLVTPRK 72

fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439086 Cd Length: 73 Bit Score: 39.53 E-value: 3.79e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958663609 312 FKPCMRVEVVDKRH---LCrtrVAVVESVIGGRLRLVYEESEDRTDDFWCHMHSPLIHHIGWSRSIGHRFK 379
Cdd:cd20096     1 FERGMKLEAVNPENpnqIC---VATITKVVGPLLWLHLDSEKKLSPNIIVDVESTDIFPVGWCESNGYPLV 68

fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439119 Cd Length: 71 Bit Score: 39.19 E-value: 5.11e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1958663609 233 LLR--YEGFENDssLDFWCNICGSDIHPVGWCAASGKPLVPP 272
Cdd:cd20129    32 LLRihFDGWEDE--YDQWVDCESPDLYPVGWCQLTGYQLQPP 71

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439102 Cd Length: 94 Bit Score: 39.20 E-value: 7.04e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 411 FKEGMKLEAIDPLNLSTICVATIRKVLADgFLMIGIDGSEAADGSDWFCYHATSpSIFPVGFCEINMIELTPPRGYTKLP 490
Cdd:cd20112     4 FQPGMKLEVANKSNPDTYWVATIITTCGQ-LLLLRYCGYGDDRRADFWCDVMTA-DLHPVGWCTQNNKVLMPPDAIKEKY 81


                  ....*..
gi 1958663609 491 FKWFDYL 497
Cdd:cd20112    82 TDWTEFL 88

first malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439110 Cd Length: 103 Bit Score: 38.29 E-value: 1.81e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958663609 521 VGMKLEAVDL---MEPRLICVATVTRIIHRLLRIHFDGWEEE--YDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20120     6 EGVRVEVPNTdcnLPTKVFWIAGIVKLAGYKALLRYEGFENDssLDFWCNICGSDIHPVGWCATSGKPLVPP 77

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) and similar proteins; L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439111 Cd Length: 102 Bit Score: 38.29 E-value: 2.16e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958663609 521 VGMKLEAVD---LMEPRLICVATVTRIIHRLLRIHFDGWEEE--YDQWVDCESPDLYPVGWCQLTGYQLQPP 587
Cdd:cd20121     6 EGMKVEVLNtdaVLPSRVYWIASVIQLAGYKALLRYEGFENDssHDFWCNLGTVDVHPIGWCAINSKILVPP 77

second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg family; The Sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, Polycomb protein sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439082 Cd Length: 75 Bit Score: 36.95 E-value: 3.34e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958663609 312 FKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEeSEDRTDDFWCHMHSPLIHHIGWSRSIGH 376
Cdd:cd20092     6 FKVGMKLEAVDRKNPQLICPATVGDVDGDEIHISFD-GWRGAFDYWCRYDSRDIFPVGWCKKTGH 69

first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439087 Cd Length: 105 Bit Score: 37.29 E-value: 4.65e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 412 KEGMKLEAI----DPLNLSTIC--VATIRKVlADGFLMIGIDGSEAADGSDwFCYHATSPSIFPVGFCEINMIELTPPRG 485
Cdd:cd20097     5 KIGVKVEVAnrddDKPTDNVKVywFARIIKV-AGYRVLLRYEGYDEDSSHD-FWINLCSNEIHPIGYAAENGKILVPPKS 82

                          90
                  ....*....|...
gi 1958663609 486 YTKLPFKWFDYLR 498
Cdd:cd20097    83 IEDKENDWKEYIM 95

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439129 Cd Length: 82 Bit Score: 36.38 E-value: 5.89e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958663609 411 FKEGMKLEAIDPLNLSTICVATIRKVlADGFLMIGIDGseaADGSDWFCYHATSPSIFPVGFCEINMIELTPPRGYT 487
Cdd:cd20139     9 FQVNMKLEAVDKRNPILIRVATIVDK-DDHRIKLHFDG---WDHNYDFWVDADSPDIHPVGWCDKTGHALQVPLGAS 81

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439101 Cd Length: 94 Bit Score: 36.73 E-value: 6.65e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958663609 406 QSGewFKEGMKLEAIDPLNLSTICVATIRKVLADgFLMIGIDGSEAADGSDWFCYHATSpSIFPVGFCEINMIELTPPRG 485
Cdd:cd20111     1 QNG--FSPGMKLEVAVRTDPNTYWVATIITTCGQ-LLLLRYDGYGEDRRADFWCDIMTA-DLHPIGWCEQNGKTLRPPEG 76

                          90
                  ....*....|....*
gi 1958663609 486 YTKLPFKWFDYLRET 500
Cdd:cd20111    77 IRDKLSDWEEFLAQT 91

third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439085 Cd Length: 92 Bit Score: 36.47 E-value: 7.14e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958663609 312 FKPCMRVEVVD---KRHLCrtrVAVVESVIGGRLRLV----YEESEDRTDDFWCHMHSPLIHHIGWSRSIG 375
Cdd:cd20095     1 FKVGMKLEALHpknPSTIC---PATVTKVFNEYYFLVeiddLRPEESEKITFVCHANSPGIFPVGWCAKNG 68