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Conserved domains on  [gi|1958662087|ref|XP_038943136|]
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fatty acid hydroxylase domain-containing protein 2 isoform X2 [Rattus norvegicus]

Protein Classification

sterol desaturase family protein( domain architecture ID 10513792)

sterol desaturase family protein is an oxidoreductase, similar to C-5 sterol desaturase, which catalyzes a dehydrogenation reaction to introduce a C5-6 double bond into substrates such as lathosterol and the B ring of ergosterol

EC:  1.-.-.-
Gene Ontology:  GO:0006629|GO:0016491

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FA_hydroxylase pfam04116
Fatty acid hydroxylase; This entry includes fatty acid and carotene hydroxylases and sterol ...
 246-354 1.30e-18

Fatty acid hydroxylase; This entry includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways. This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif which coordinate two irons at the catalytic centre. Members of this family are ER integral membrane proteins that share a novel mushroom-shaped fold consisting of four transmembrane (TM1-TM4) helices that anchor them to the membrane capped by a cytosolic domain containing the unique histidine- coordinating di metal centre.


:

Pssm-ID: 397991  Cd Length: 134  Bit Score: 80.94  E-value: 1.30e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958662087 246 LVLFTLVQEILFYYSHRLFHH-PKLFKKVHKKHHEWTTPIGLISIYADPIEHVVSNmLPVMVGPLAMGSHLSSITVWLSL 324
Cdd:pfam04116   1 VLLGLLLFDFLFYWVHRLLHRlPWLWRRFHKVHHSSEAPNALTALRFHPLEALLFA-LLVLLPLLLLGLPLLAFLLGLLL 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1958662087 325 VLIVSSITHCGYHLPF-------LPSPEFHDYHHLKF 354
Cdd:pfam04116  80 GTLWYLFIHSGLLFPLpwllkrlLGTPRFHRLHHSKN 116
Exportin-5 super family cl44708
Exportin-5 family; Exportin-5 mediates the nuclear export of proteins bearing a ...
 187-247 7.53e-03

Exportin-5 family; Exportin-5 mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). Exportin-5 yeast homolog, also known as Msn5, is involved in nuclear import of replication protein A and export of Far1 and transcription factors Swi5, Swi6, Msn2, and Pho4. Its Arabidopsis homolog, HASTY 1, is involved in the nuclear export of microRNAs (miRNAs).


The actual alignment was detected with superfamily member pfam19273:

Pssm-ID: 437105  Cd Length: 811  Bit Score: 38.18  E-value: 7.53e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958662087 187 QLDKNEPVDPVKLRQSIRTVIFNQSVISFPMLVILYPFLKWTGDPCCRELPTFHWILVELV 247
Cdd:pfam19273 643 QMGDDESMDASSLKDSLVKYLLKHIDVATPLLHTLIHLLSWKDTEAVHKVASFCGILILLA 703
 
Name Accession Description Interval E-value
FA_hydroxylase pfam04116
Fatty acid hydroxylase; This entry includes fatty acid and carotene hydroxylases and sterol ...
 246-354 1.30e-18

Fatty acid hydroxylase; This entry includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways. This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif which coordinate two irons at the catalytic centre. Members of this family are ER integral membrane proteins that share a novel mushroom-shaped fold consisting of four transmembrane (TM1-TM4) helices that anchor them to the membrane capped by a cytosolic domain containing the unique histidine- coordinating di metal centre.


Pssm-ID: 397991  Cd Length: 134  Bit Score: 80.94  E-value: 1.30e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958662087 246 LVLFTLVQEILFYYSHRLFHH-PKLFKKVHKKHHEWTTPIGLISIYADPIEHVVSNmLPVMVGPLAMGSHLSSITVWLSL 324
Cdd:pfam04116   1 VLLGLLLFDFLFYWVHRLLHRlPWLWRRFHKVHHSSEAPNALTALRFHPLEALLFA-LLVLLPLLLLGLPLLAFLLGLLL 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1958662087 325 VLIVSSITHCGYHLPF-------LPSPEFHDYHHLKF 354
Cdd:pfam04116  80 GTLWYLFIHSGLLFPLpwllkrlLGTPRFHRLHHSKN 116
ERG3 COG3000
Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid ...
 246-351 1.39e-13

Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism];


Pssm-ID: 442238  Cd Length: 158  Bit Score: 67.65  E-value: 1.39e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958662087 246 LVLFTLVQEILFYYSHRLFHHPKLFKKVHKKHHEWTTPIGLISIYADPIEHVVSnMLPVMVGPLAMGSHLSSITVWLSLV 325
Cdd:COG3000     2 FLLAFLLLDFVYYWLHRLSHRVPLLWRFHAVHHSSERMNLLTALRFHPLEILLS-ALLFLLPLALLGFPPEAVLLYLALN 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1958662087 326 LIVSSITHCGYHLP-------FLPSPEFHDYHH 351
Cdd:COG3000    81 LLYQFFNHSNIRLPldgpleyVFVTPSHHRVHH 113
PLN02869 PLN02869
fatty aldehyde decarbonylase
 242-354 8.33e-07

fatty aldehyde decarbonylase


Pssm-ID: 166510 [Multi-domain]  Cd Length: 620  Bit Score: 50.61  E-value: 8.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958662087 242 ILVELVLFTLVQEILFYYSHRLFHHPKLFKKVHKKHHEW--TTPI-GLISIYADPIEHVVSNMLPVMVGPLAMGSHLSSI 318
Cdd:PLN02869  127 VLITILLHMGPVEFLYYWLHRALHHHYLYSRYHSHHHSSivTEPItSVIHPFAEHIAYFLLFAIPLLTTIFTGTASIAAF 206

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1958662087 319 TVWLSLVLIVSSITHCGYHL---------PFLP----SPEFHDYHHLKF 354
Cdd:PLN02869  207 FGYISYIDFMNNMGHCNFELipkwlfsifPPLKylmyTPSYHSLHHTQF 255
Exportin-5 pfam19273
Exportin-5 family; Exportin-5 mediates the nuclear export of proteins bearing a ...
 187-247 7.53e-03

Exportin-5 family; Exportin-5 mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). Exportin-5 yeast homolog, also known as Msn5, is involved in nuclear import of replication protein A and export of Far1 and transcription factors Swi5, Swi6, Msn2, and Pho4. Its Arabidopsis homolog, HASTY 1, is involved in the nuclear export of microRNAs (miRNAs).


Pssm-ID: 437105  Cd Length: 811  Bit Score: 38.18  E-value: 7.53e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958662087 187 QLDKNEPVDPVKLRQSIRTVIFNQSVISFPMLVILYPFLKWTGDPCCRELPTFHWILVELV 247
Cdd:pfam19273 643 QMGDDESMDASSLKDSLVKYLLKHIDVATPLLHTLIHLLSWKDTEAVHKVASFCGILILLA 703
 
Name Accession Description Interval E-value
FA_hydroxylase pfam04116
Fatty acid hydroxylase; This entry includes fatty acid and carotene hydroxylases and sterol ...
 246-354 1.30e-18

Fatty acid hydroxylase; This entry includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways. This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif which coordinate two irons at the catalytic centre. Members of this family are ER integral membrane proteins that share a novel mushroom-shaped fold consisting of four transmembrane (TM1-TM4) helices that anchor them to the membrane capped by a cytosolic domain containing the unique histidine- coordinating di metal centre.


Pssm-ID: 397991  Cd Length: 134  Bit Score: 80.94  E-value: 1.30e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958662087 246 LVLFTLVQEILFYYSHRLFHH-PKLFKKVHKKHHEWTTPIGLISIYADPIEHVVSNmLPVMVGPLAMGSHLSSITVWLSL 324
Cdd:pfam04116   1 VLLGLLLFDFLFYWVHRLLHRlPWLWRRFHKVHHSSEAPNALTALRFHPLEALLFA-LLVLLPLLLLGLPLLAFLLGLLL 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1958662087 325 VLIVSSITHCGYHLPF-------LPSPEFHDYHHLKF 354
Cdd:pfam04116  80 GTLWYLFIHSGLLFPLpwllkrlLGTPRFHRLHHSKN 116
ERG3 COG3000
Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid ...
 246-351 1.39e-13

Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism];


Pssm-ID: 442238  Cd Length: 158  Bit Score: 67.65  E-value: 1.39e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958662087 246 LVLFTLVQEILFYYSHRLFHHPKLFKKVHKKHHEWTTPIGLISIYADPIEHVVSnMLPVMVGPLAMGSHLSSITVWLSLV 325
Cdd:COG3000     2 FLLAFLLLDFVYYWLHRLSHRVPLLWRFHAVHHSSERMNLLTALRFHPLEILLS-ALLFLLPLALLGFPPEAVLLYLALN 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1958662087 326 LIVSSITHCGYHLP-------FLPSPEFHDYHH 351
Cdd:COG3000    81 LLYQFFNHSNIRLPldgpleyVFVTPSHHRVHH 113
PLN02869 PLN02869
fatty aldehyde decarbonylase
 242-354 8.33e-07

fatty aldehyde decarbonylase


Pssm-ID: 166510 [Multi-domain]  Cd Length: 620  Bit Score: 50.61  E-value: 8.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958662087 242 ILVELVLFTLVQEILFYYSHRLFHHPKLFKKVHKKHHEW--TTPI-GLISIYADPIEHVVSNMLPVMVGPLAMGSHLSSI 318
Cdd:PLN02869  127 VLITILLHMGPVEFLYYWLHRALHHHYLYSRYHSHHHSSivTEPItSVIHPFAEHIAYFLLFAIPLLTTIFTGTASIAAF 206

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1958662087 319 TVWLSLVLIVSSITHCGYHL---------PFLP----SPEFHDYHHLKF 354
Cdd:PLN02869  207 FGYISYIDFMNNMGHCNFELipkwlfsifPPLKylmyTPSYHSLHHTQF 255
Exportin-5 pfam19273
Exportin-5 family; Exportin-5 mediates the nuclear export of proteins bearing a ...
 187-247 7.53e-03

Exportin-5 family; Exportin-5 mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). Exportin-5 yeast homolog, also known as Msn5, is involved in nuclear import of replication protein A and export of Far1 and transcription factors Swi5, Swi6, Msn2, and Pho4. Its Arabidopsis homolog, HASTY 1, is involved in the nuclear export of microRNAs (miRNAs).


Pssm-ID: 437105  Cd Length: 811  Bit Score: 38.18  E-value: 7.53e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958662087 187 QLDKNEPVDPVKLRQSIRTVIFNQSVISFPMLVILYPFLKWTGDPCCRELPTFHWILVELV 247
Cdd:pfam19273 643 QMGDDESMDASSLKDSLVKYLLKHIDVATPLLHTLIHLLSWKDTEAVHKVASFCGILILLA 703
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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